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Hodgkin and Non-Hodgkin Lymphomas
Stage I is defined as involvement of a single lymphatic site (i.e., nodal region, Waldeyer’s
ring, thymus or spleen). Illustrated is involvement of the cervical nodal region.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage I is defined as involvement of a single lymphatic site (i.e., nodal region, Waldeyer’s
ring, thymus or spleen). Illustrated is the inguinal nodal region.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IE is defined as localized involvement of a single extralymphatic organ or site in
the absence of any lymph node involvement (rare in Hodgkin lymphoma). Illustrated
is small intestine involvement.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage II is defined as involvement of two or more lymph node regions on the same side
of the diaphragm. Illustrated are nodes above the diaphragm.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage II is defined as involvement of two or more lymph node regions on the same side
of the diaphragm. Illustrated are nodes below the diaphragm.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IIE is defined as localized involvement of a single extralymphatic organ or site in association
with regional lymph node involvement with or without involvement of other lymph node regions on
the same side of the diaphragm. Illustrated are involvement of the small intestine and nodes below
the diaphragm.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IIE is defined as localized involvement of a single extralymphatic organ or site in association
with regional lymph node involvement with or without involvement of other lymph node regions on
the same side of the diaphragm. Illustrated are involvement of the lung with hilar and mediastinal
node involvement.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage III is defined as involvement of lymph node regions on both sides
of the diaphragm.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IIIE is defined as involvement of lymph node regions on the opposite side of the
diaphragm from the extralymphatic extension in association with adjacent lymph node
involvement. Illustrated are nodes on both sides of the diaphragm with
the small intestine.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IIIS is defined as involvement of node regions on both sides of the diaphragm accompanied by
involvement of the spleen. Stage IIIE,S is defined as involvement of node regions on both sides
of the diaphragm, and involving both an extralymphatic organ and the spleen (as illustrated).
Splenic involvement is designated by the letter S.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IV is defined as diffuse or disseminated involvement of one or more extralymphatic
organs, with or without associated lymph node involvement. Illustrated is diffuse
involvement of the brain with multiple lesions.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer
Hodgkin and Non-Hodgkin Lymphomas
Stage IV includes any involvement of the liver (as illustrated), or bone marrow (as
illustrated), or lungs (other than by direct extension from another site), or
cerebrospinal fluid.
Compton, C.C., Byrd, D.R., et al., Editors. AJCC CancerStaging Atlas, 2nd Edition. New York: Springer, 2012. ©American Joint Committee on Cancer