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FGF Receptor 3
…and its role in Bladder Cancer
Jenny Espinosa
Biology 169
March 30, 2004
What is it?
Just what is FGFR3 anyway?
• Fibroblast Growth Factor Receptor 3
 Receptor Tyrosine Kinase
 Glycoprotein
• Contains extracellular immunoglobulin domains, a
hydrophobic transmembrane domain, & a split tyrosinekinase domain
• Two isoforms: FGFR3b and FGFR3c
• Found in the plasma membrane
Normally found in:
Rat
Frog
Mouse
Zebrafish
Fruitfly
As well as in…
US!!
So what does it do??
Michiyuki Kanai, Mchael Goke, Shoji Tsunekawa and Daniel Podolsky
Yeah,
but what does it really do?!
• Involved in a developmental pathway
• Negative regulator of bone growth
• Promotion & inhibition of chondrocyte proliferation
and differentiation (mouse)
• Regulation of epithelial cell growth & differentiation
• Involved in embryogenesis, angiogenesis, and wound healing
Main point here…
REGULATION OF CELL PROLIFERATION
AND DIFFERENTIATION
Hmm…
what happens then
if the cell is mutated?
FGFR
extracellular
domain
- Achondroplasia*
- Thanatophoric dysplasia*
- Non-syndromic cranial
synostosis
- Crouzonodermoskeletal
syndrome
FGFR
intracellular
domain
David M. Ornitz & Pierre J. Marie
- Hypochondroplasia*
Effects of activated
FGFR3 in Mice
What role does it play
in
CANCER ??
FGFR3 and Bladder Cancer
http://www.hollywoodurology.com/tcc.html
Bladder Cancer
– somatic mutation in bladder carcinomas
(superficial or low-grade)
– (74%) in non-invasive papillary tumors
– absence of mutations in carcinoma in situ
– recurrence more frequent in wild type FGFR3
That’s all
folks!