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IKnife
Vi Tran
BME 281
November 20, 2013
Challenges of Tumor Removal
-Difficulty in establishing exact boundaries of cancerous tissue
-Any uncertain tissue is sent to laboratory to analyze
-30 minute process, time consuming
IKnife
- “Intelligent” Knife
- Surgical knife that instantly
identifies cancerous tissue as it
cuts through tissue
- Takes about 1 to 3 seconds
- Designed by Zoltan Takatas, a
Hungarian chemist at Imperial
College in London in 2013
How It Works
-Consists of a electrosurgical knife
that is connected to mass
spectrometer
-Heat is generated through knife as
it cuts through tissue
-Smoke is produced and is analyzed
by mass spectrometer
-Since cancerous tissue has more
phospholipids and different ion
composition than healthy tissue the
machine analyzes the chemical
composition of the smoke to
differentiate between the two
tissues
Results
-Results highly successfully
-Tested products in two ways
-Researchers took tissue samples from 302 patients and performed an analysis using
Iknife
-Was able to correctly differienate tissue
-Used in operating room on 91 random patients
-Results highly accurate
Benefits and Future
-Able to instantly identify cancerous tissue in operating room
-Eliminates need to send tissue to laboratory for analysis
-Minimizes surgery time
-Costs 200,000 pounds(approximately $380,000 US currency) to make this device
-Price will drop once it becomes commercially produced
-Researchers are currently working to improve this device
-Clinical trials will probably occur in 2 to 3 years
-As newer developments are being made, this will help lives of many people
Works Cited
Gallangher, James. "Cancer Surgery: Tumour 'sniffing' Surgical Knife Designed."
BBC, 2013. Web. 17 Nov. 2013. <http://www.bbc.co.uk/news/health-23348661>.
Moore, Elizabeth A. CNET, 18 July 2013. Web. 17 Nov. 2013. <Intelligent 'iKnife'
diagnoses cancer midsurgery>.
Scientists Develop IKnife That Helps Surgeons Identify Cancerous Tissues. News
Medical, 18 July 2013. Web. 17 Nov. 2013. <http://www.newsmedical.net/news/20130718/Scientists-develop-iKnife-that-helps-surgeonsidentify-cancerous-tissues.aspx>.
Thomas, Dennis. Knife' Tells Surgeon Whether Tissue Is Cancerous. WebMD LLC,
2013. Web. 17 Nov. 2013.
<http://www.webmd.com/cancer/news/20130717/experimental-iknife-tellssurgeon-whether-tissue-is-cancerous?page=1>.
Wong, Samuel. ""Intelligent Knife" Tells Surgeon If Tissue Is Cancerous." N.p., n.d.
Web. 17 Nov. 2013.
<http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssumm
ary/news_17-7-2013-17-17-32>