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Max Brinsmead PhD FRANZCOG July 2010 The common causes are… Pregnancy-related ○ Successful but threatening to miscarry ○ Unsuccessful & aborting ○ Retained products of conception - After normal pregnancy or miscarriage ○ Ectopic Cervical Bleeding Benign Ectropion, Cervicitis or Polyp Cancer of the cervix Bleeding from the uterine cavity Benign Fibroids and Polyps Cancer Dysfunctional uterine bleeding But also keep in mind… Hormones that have been given ○ Depoprovera (or DMP or DMPA) ○ Oral contraceptives (COC) ○ Other Bleeding disorders ○ Rare ○ Usually associated with other bleeding or bruising When a patient complains about abnormal vaginal bleeding... First determine if she has: ○ Regular but heavy or prolonged periods This is called menorrhagia It is a common manifestation of fibroids Rarely due to a bleeding disorder ○ Regular periods with bleeding at other times If the bleeding is postcoital it should be regarded as cancer of the cervix until proven otherwise ○ Irregular bleeding This may be dysfunctional uterine bleeding but this diagnosis is usually only made when other causes are excluded And always exclude pregnancy Best done by pregnancy test Consider your patient’s age… If the patient is young (<35 years) ○ Cancer is uncommon If the patient is very young & never sexually active ○ Pregnancy, STD and Ca cervix never occurs ○ But dysfunctional uterine bleeding is not uncommon If the patient is >40 years ○ Cancer from within the uterine cavity can only be excluded by endometrial biopsy or curette ○ But dysfunctional bleeding is not uncommon You must always examine… Look for signs of anaemia Examine the abdomen to see if there is a uterus or other mass arising out of the pelvis Pass a speculum and decide if the bleeding is coming from or through the cervix Examine the pelvis bimanually to see if the uterus is enlarged ○ (And if the cervix feels normal if it looked abnormal) Dysfunctional Uterine Bleeding (DUB) Often a history of missed periods or irregular cycles May be associated with obesity and hirsutism (PCO Disorder) Bleeding is usually painless unless there is clot colic Bleeding can be very heavy or quite prolonged There is a normal cervix and the uterus is not enlarged Management of Abnormal Vaginal Bleeding Antibiotics have no place nor role Bleeding from an abnormal cervix is rarely a life-threatening emergency but it requires referral for further testing and treatment Transfusion should be reserved for those with severe anaemia and in whom you cannot immediately control the bleeding Uterine bleeding after the age of 40 requires referral for D&C Dysfunctional uterine bleeding can be treated with Pills Management of Dysfunctional Uterine Bleeding Bleeding can be controlled with Norethisterone (5 mg tablets) Give 2 tablets every 2 – 3 hours until the bleeding slows or stops Then 5 mg BD for 10 – 14 days The patient can then expect a “normal period” a few days after stopping the pills Give COC in the next cycle or Norethisterone 5 mg BD from day 10 – 25 of each cycle for 4 – 6 months Give iron & folate to treat anaemia Emergency treatment of any Endometrial Bleeding When the blood is coming through the cervix Even if the patient is >40 years Or if the uterus is enlarged by adenomyosis or fibroids Or the patient has a bleeding disorder You can try Norethisterone 10 mg every 2 – 3 hours But refer also for further Ix and Rx Management of Hormone-related PV bleeding Irregular PV bleeding with Depoprovera or COC is secondary to their effect on the endometrium But make sure that the cervix is normal Then try Norethisterone as per DUB regimen Or give Premarin 1.25 mg 8 hourly Or any COC one tablet 6 hourly Or just give another injection of Depoprovera