Download Cancer

Cancer
Cells Gone
Wild!
Cancer Cell
• Surrounded by T-cells
and dead
How are cancer cells different from
most cells?
• Do not have a normally
functioning cell cycle
• Divide excessively and can
invade other tissue
Tumor
• Abnormal mass of cells
• Skin
Lung
Normal vs . Tumor Growth
Benign Vs. Malignant
• Benign-mass
of normal
cells at original
site
• Malignantcancerous and
can spread
to other cells
Tumor
• Abnormal mass of cells
Metastasis
• Spread of cancer
cells beyond
their original site
Metastasis of prostate tumor cells
• Into bone cells
Carcinogens
• Any substance involved in the
promotion of cancer:
• gamma rays, X-rays, UV rays
• Dioxin (pesticide)
• Tobacco smoke
• Asbestos
• HPV virus
Cancers are named
• According to the
tissue or organ in
which they
originate
4 types of Cancers
• Carcinomas
• Sarcomas
• Lymphomas
• Leukemias
Carcinomas
• Cancers
that
originate on
external or
internal
coverings
(skin, lining
of intestine)
Carcinoma Forming
Sarcomas
• Arise in tissue
that support the
body (bone and
muscle)
leukemia
• cancer in leukocytes (white
blood cells) in bone marrow
• (too many white
blood cells and
not enough
red blood cells)
lymphomas
malignant
cells in
the
lymph
•
system
Lymphatic System
• Works with
circulatory system to
filter clear fluid
• (transports white
blood cells)
• Lymphatic System You
Tube
Cancer Populations
Cancer Gene Checker
• The p53
Tumor
Suppressor
Gene
Triggers
Cell Suicide
FYI p27 on chromosome 12
• Inhibitor of cdk regulator of
cell cycle
• High levels of p27 shown in
breast cancers
Normal Cell Divisions
• Mammalian Cells will divide
about 50 times in a culture
3 ways to treat cancer
• 1. Surgically remove
• 2. Radiation
• 3. Chemotherapy
Surgically Removal
Radiation Treatment
• To kill cancer cells
Usually X-rays
and gamma
rays to target
the cancer
cells
Chemotherapy Drugs
Cancer Fighting Drugs: work on
mitotic spindles
• TAXOL
• VINBLASTIN
• Paclitaxol
• Prevents mitotic
• Freezes the mitotic
spindles from
spindles after it
forming
forms
• From periwinkle
• From Yew plant