Colorectal Cancer Treatment Options by Stage of Diagnosis The information below will help you understand some of the treatment options available during each stage of colorectal cancer. Stages of Colorectal Cancer The stage describes the extent of the cancer in the body and is one of the most important factors in determining prognosis and treatment options. The higher stages of cancer require advanced treatment options. Stage Surgery Chemotherapy/Biologics Radiation Interventional Radiology Stage 0 Yes No No No Stage I Yes No No No Stage II Yes Yes, for rectal and high risk colon cancers. FOLFOX (5-FU/ Leucovorin/Oxaliplatin) or CapeOx (Capecitabine/ Oxaliplatin) Yes, for rectal cancer. Given in tandem with 5-FU or Xeloda No Stage III Yes FOLFOX or CapeOx Yes, for rectal cancer. Given in tandem with 5-FU or Xeloda No Stage 0 = Earliest stage of cancer Stage IV Yes, if the tumor is obstructive or blocking the bowel FOLFOX or FOLFIRI (5-FU/Leucovorin/Irinotecan) plus Bevacizumab or Cetuximab or Panitumumab or Ziv-aflibercept or Regorafenib (if previously treated with these other options) Yes, for rectal cancer and in certain other cases Possibly. Options could be Radio Frequency Ablation (RFA) or chemoembolization Stage IV= Most advanced stage of cancer No, if the tumor is not blocking the bowel Treatment Options for Colorectal Cancer Understanding all the treatment options available to you can be overwhelming. What treatment will work for you? Which methods have proven to be most effective? Use this guide to explore your choices, get the facts about the latest breakthroughs, and understand what each treatment option involves so you can work with your doctor to make an informed decision. Clinical trials are also available for all stages of colorectal cancer. Surgery/Resection Resection is the partial or complete removal of an organ, such as the colon, liver or lung. Chemotherapy Chemotherapy refers to treatment using chemicals to kill cells that divide rapidly, such as harmful cancer cells. Trade Name Generic Name 5Fluorouracil (5FU) --- Camptosar Irinotecan/CPT-11 Xeloda Capecitabine Eloxatin Oxaliplatin Stivarga Regorafenib Biologics Biologics include a wide range of substances from animal products and other living sources (as opposed to chemically manufactured medications) to prevent, diagnose or treat disease. Trade Name Generic Name Avastin Bevacizumab Erbitux Cetuximab Vectibix Panitumumab Zaltrap Ziv-aflibercept Interventional Radiology Interventional Radiology is a minimally invasive procedure involving the precise placement of a needle into the body using imaging (MRI, X-ray, etc.) to target treatment to the source of the disease. Treatment Types • Radio Frequency Ablation (RFA) – This procedure is used to treat unresectable metastatic disease. An electrical current is used to burn away the remaining tumor. • Chemoembolization – Cancer-fighting agents are injected directly to the site of a cancer tumor. • Microspheres – This procedure uses a catheter to deliver tiny beads called microspheres that are coated with radiation, directly into the tumor. (877) 422-2030 • ccalliance.org The Colon Cancer Alliance, Inc. is a not-for-profit 501(c)3 corporation. Tax ID# 86-0947831.