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Systems Biology at the
Center for BioSystemsAnalysis ZBSA
Systems Biology
"Systems biology...is about putting together
rather than taking apart, integration rather than
reduction. It requires that we develop ways of
thinking about integration that are as rigorous as
our reductionist programmes, but different....It
means changing our philosophy, in the full sense
of the term“ Denis Nobel, 2006
„To understand complex biological systems
requires the integration of experimental and
computational research -- in other words a
systems biology approach“ Hiroaki Kitano, Nature
2002
NEW KNOWLEDGE
NEW
DATA
NEW
DATA
HYPOTHESIS
IN SILICO EXPERIMENT
(SIMULATION)
IN VITRO-/ IN VIVOEXPERIMENT
MATHEMATICAL
MODEL
EXPERIMENTAL DATA;
KNOWLEDGE OF STRUCTURES;
FUNCTIONS AND INTERACTIONS
BIOLOGICAL
PHENOMENON
Life Sciences, Engineering, Computer Sciences
and Mathematics merge at the ZBSA
NATURE|Vol 445|22 February 2007
ZBSA
Prof. Ralf Baumeister
Founding Director (2006-09)
Prof. Jens Timmer
Acting Director
2009-10
Prof. Wolfgang Driever
Initiator (2001-05)
Director since 7/2010
Scientists from six faculties work together in
multidisziplinary projects at the ZBSA
Biology
Medicine
Mathematic
s
Physics
Forestry and
Environment
Informatics and
Microsystems
Chemistry
Pharmacology
Bernstein Center
for Computational
Neuroscience
Structure of the ZBSA
Systems Biology
Genes,
Gene
Networks
Proteins,
ProteinNetworks
Metabolites,
metabobic
Neworks
Metabolomics
Genomics
Proteomics
Life Imaging
Genetic disposition
Development
Environment
ZBSA – an Interdisciplinary Center
Technologies
Genomics
Proteomics
Imaging
Metabolomics
Junior Groups
Land Baden-Württemberg:
Seminars and Meetings
IT and Theory
Data Analysis
Modelling
Building: 17,5 Mio Euro
Equipement: 2,5 Mio Euro
Core Facilities for Quantitative High Quality Data:
The Experimental Basis for Modelling
and Systems Analysis
Genomics
Dr. Kurz
Proteomics
Dr. Schlosser
Metabolomics
Dr. Kammerer
Life Imaging
Dr. Nitschke
The ZBSA is instrumental for the excellence
research centers at the University of Freiburg
Graduate School
Research Cluster of Excellence
FRIAS LiFENET
Freiburg Institute of Advanced Studies
Complex systems – systems biology
The Freiburg Initiative for Systems
Biology - FRISYS
Coordinator: Wolfgang R. Hess
 Integration of theoretical and experimental
efforts to define intact biological systems
 Modelling and systems’ analysis of signalling
processes in growth and differentiation
 Model organisms at phylogenetic key
positions
 Dedicated Systems Biology curriculum in
order to train highly qualified scientists for
this field
Systembiologie
des Alterns
Promotion
of Junior
Faculty
TOR
ModellingPI3K
Hauke Busch
PIP2
FRIAS LIFENET
Raptor
PIP3
PINK1
S6K
GRB-2
SOS
RAS
JKK
PTEN
SIR2
PDK1
eIF4B
SHC-1
Networks
Enrico Schmidt
MAPKKK
FRISYS/bioss
MAPKK
DJ1
?
developmental
+neuronal signals
RAF
JNK
MAPK
Robotics and
AKT2
Automation
? Proteomics
AKT1
SGK1
Jörn Dengjel
Anke BeckerSKN-1
FOXO
FRIAS LIFENET FRISYS
FOXO
MEK
MAPK
SKN1
14 Junior Faculty at ZBSA
cellular senescence
protein integrity
stress control
EGFR
InsR
Tilmann Brummer
bioss
?
PEPT1
stress
?
stress,
insulin
Signalling
nutrients
+?
stress response
Parkin?
ageing,
telomere maintenance
stress response
ageing
cell cycle control
apoptosis
Research – Strategic Areas
• Systems biology of development and
differentiation
• Signaling and decision mechanisms in
cell populations
• Dynamic control of cell states by
transcriptional networks and regulatory
RNAs
Research – Future plans
• Collaborative Research Center CRC of
German Research Council DFG
• Quantitative analysis and modelling of
mechanisms in development and
differentiation
• Trinational initiative of Freiburg with
– IGBMC Strasbourg
– BSSE / ETH at Basel
International Network
Systems Biology
In the D – F – CH
Trinational region
Strasbourg
Legend:
EUCOR University
SystemsX
Basel/Zurich
Where are all the ZBSA
Systems Biologists?
Where are all the ZBSA
Systems Biologists?
2nd Annual ZBSA Retreat
Feldberg-Altglasshütten
November 10-11
2010
Thank you for your
attention!
Wolfgang Driever
Systems Biology
•
•
•
•
"Systems Biology aims at an improved understanding of biology and its mechanisms, in
particular of the functions and interactions of key elements of living systems (DNA, RNA,
proteins, cells).
Systems biology is the sum of novel methodological approaches to (a) gather and analyse
this knowledge, (b) to translate this knowledge into a thorough understanding that
eventually will allow predicting the behavior of the complex and dynamic networks that
regulate living specimen.
The focus of systems biology is clearly not limited to the description of existing knowledge
using a different syntax, but aims at combining available methods synergistically to
develop novel approaches for the characterization of the behavior of biological networks.
Whereas traditional research in the Life Sciences generally emphasizes the operational
necessity of a gene, protein, component for the correct execution of a particular pathway
or regulatory mechanism (what is it doing, is it necessary or sufficient?), it is the Systems
Biology that expands these questions in an attempt to define the relevance of a particular
component or mechanism for fulfilling a biological goal (Why is it performing the way it is to
accomplish this or that task? How does the component need to be designed in order to
fulfill its function)."
Prof. Ralf Baumeister
Director ZBSA 2005-2009