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Active Lecture Questions for
BIOLOGY, Eighth Edition
Neil Campbell & Jane Reece
Chapter 16
The Molecular Basis of Inheritance
Questions prepared by
Louise Paquin,
McDaniel College
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
The DNA Model
What kind of evidence about the structure of DNA
came from each of the following branches of
science?
a) physics
b) chemistry
c) biology
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
The Genetic Material
If the result of the Hershey and Chase experiment
had been that radioactive sulfur (35S) was found
inside the cells instead of radioactive phosphorous
(32P), what could have been concluded?
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Semiconservative Replication
Define and diagram “semiconservative” as it applies
to DNA replication.
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Replication
If a segment of DNA (circular or linear) is able to
replicate, it must include which of the following?
a) two double helices
b) at least one origin of replication
c) at least 3 million nucleotide pairs
d) two or more mutated regions
e) a binding site for ligase
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Replication Enzymes
In what order do the following enzymes and
polypeptides function during replication?
a) single-strand binding proteins
b) DNA polymerase III
c) helicase
d) primase
e) topoisomerase
f) ligase
g) DNA polymerase I
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Replication
Where and how is a
new nucleotide added
to the DNA strand
during replication?
What enzyme is
needed?
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Telomeres
Telomeres, or the ends of linear chromosomes, have
special structure and function, even though they are
non-coding. Describe their structure and function.
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Shortened Ends
What enzyme does a gamete-producing cell include
that compensates for replication-associated
shortening?
a) DNA polymerase II
b) ligase
c) telomerase
d) DNA nuclease
e) proofreading enzyme
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Packaging
Arrange the following in order of size, from
smallest to largest.
a) scaffolded domains
b) double helix
c) metaphase chromosome
d) nucleosome
e) 30 nm fiber
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.
Heterochromatin
Which of the following is true of heterochromatin
but not of euchromatin?
a) It is accessible to enzymes needed for gene
expression.
b) It becomes less tightly compacted after cell division.
c) It includes DNA primarily found in expressed genes.
d) It appears more pale when observed
microscopically.
e) It remains tightly coiled at the G1 phase.
Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings.