Download chapter 11

CHAPTER 11
Regulation of Gene Expression
in Eukaryotes
Copyright 2008 © W H Freeman and Company
CHAPTER OUTLINE
11.1 Transcriptional regulation in eukaryotes: an overview
11.2 Lessons from yeast: the GAL system
11.3 Dynamic chromatin and eukaryotic gene regulation
11.4 Enhancers: cooperative interactions, combinatorial
control, and chromatin remodeling
11.5 Genomic imprinting
11.6 Chromatin domains and their inheritance
The MSL complex enhances gene expression on the X chromosome
Chapter 11 Opener
The first cloned mammal
Figure 11-1
Overview of transcriptional regulation
Figure 11-2
Promoter-proximal elements precede the promoter of a
eukaryotic gene
Figure 11-3
Promoter-proximal elements are necessary for efficient
transcription
Figure 11-4
Model Organism Yeast
Model Organism: Yeast
Model Organism Yeast
Model Organism: Yeast
The Gal pathway
Figure 11-5
Transcriptional activator proteins bind to UAS elements in yeast
Figure 11-6
Transcriptional activator proteins are modular
Figure 11-7
Transcriptional activator proteins may be activated by an inducer
Figure 11-8
Transcriptional activator proteins recruit the transcriptional
machinery
Figure 11-9
The structure of chromatin
Figure 11-10a
The structure of chromatin
Figure 11-10b
Chromatin remodeling exposes regulatory sequences
Figure 11-11
Modified histone tails protrude from the nucleosome
Figure 11-12
Histone deacetylation can turn off gene transcription
Figure 11-13
Enhanceosomes help recruit the transcriptional machinery
Figure 11-14
Enhanceosomes recruit chromatin remodelers
Figure 11-15
Enhanceosomes recruit chromatin remodelers
Figure 11-15 part 1
Enhanceosomes recruit chromatin remodelers
Figure 11-15 part 2
Enhanceosomes recruit chromatin remodelers
Figure 11-15 part 3
Combinations of regulatory proteins control cell types
Figure 11-16
Enhancer-blocking insulators prevent enhancer activation
Figure 11-17
Model for how enhancer-blocking insulators might work
Figure 11-18
Genomic imprinting requires insulators
Figure 11-19
Unusual inheritance of imprinted genes
Figure 11-20
Steps required for imprinting
Figure 11-21
Mating-type switching is controlled by recombination of DNA cassettes
Figure 11-22
Gene silencing is caused by the spread of heterochromatin
Figure 11-23
Some genes enhance or suppress the spread of heterochromatin
Figure 11-24
Heterochromatin may spread farther in some cells than in others
Figure 11-25
Barrier insulators stop the spread of heterochromatin
Figure 11-26
Different mechanisms of dosage compensation
Figure 11-27
Inheritance of chromatin states
Figure 11-28
A model for the inheritance of DNA methylation
Figure 11-29