Download Course introduction

Introduction
Bioinformatics and Comparative Genome
Analysis
Fredj Tekaia
Institut Pasteur
[email protected]
Bioinformatic and Comparative Genome Analysis Course
HKU-Pasteur Research Centre - Hong Kong, China
August 17 - August 29, 2009
Bioinformatics and Comparative Genome
Analysis
August 16 - August 29, 2009
HKU-Pasteur Research Centre - Hong Kong
Organizers/Contact:
• Roberto Bruzzone, HKU-Pasteur Research Centre - Hong Kong;
• Si Lok, Genome Research Centre the University of Hong Kong;
• Tin Wee Tan, National University of Singapore - Singapore;
• Ueng-Cheng Yang, National Yang-Ming University, Taipei - Taiwan;
• Fredj Tekaia, Institut Pasteur Paris, France.
Course web page: http://www.pasteur.fr/~tekaia/BCGA2009.html
Why this course ?
889
65
Tree of life
115
http://www.genomesonline.org/
Complete genomes
5207 projects
• 1069 published
(02-08-09)
• 2755 Bacteria
• 107 Archaea
• 1108 Eukaryotes
• 168 metagenomes
• 3 phylogenetic
domains;
• Lifestyles:
mesophiles;
(hyper)thermophiles;
psychrophiles;
extreme conditions,...
Number of sequencing projects
Number of completely sequencing genome projects
2300
2200
2100
2000
1900
1800
1700
1600
1500
1400
1300
1200
1100
1000
900
800
700
600
500
400
300
200
100
0
2117
5207 projects
916
700
471
2
5
12
19
24
42
165
71 116
95
96
97
98
99
00
01
02
03
224
04
323
05
06
07
08
09
08-2009
Years
Completely sequencing Genomes that span the three
domains of life are growing at a rapid rate
GOLD
Genome studies show that:
• Access to entire genome sequences has revolutionized
our understanding of how genetic information is stored
and organized in DNA, and how it has evolved over time.
• The sequence of a genome provides significant details of
the gene catalogue within a species.
• Comparisons of complete genome sequences show the
acceleration in the understanding of species organisation,
links between genes, functions of the genes, evolution of
genes, genomes and species.
=> Beyond fundamental biological and methodological interests,
Expected applications include: Drug, Medical and Agricultural,…
discoveries… and their health and economical concequences.
• Few scientists are involved in generating data
and much more are involved in data analyses
Genomics
Is the study of genomes.
(including the study of their genes, proteins,
their sequences, functions, evolution,....)
Bioinformatics is needed to transform the
flood of raw data (sequences) into scientific
knowledge.
Mathematics
Statistics
Bioinformatics
Nucleotide & protein
sequences and related
informations
Biology
Informatics
Bioinformatics and Comparative Genome
Analysis
The main objectives of the course are to familiarize
the selected students with bioinformatics and
large scale genome data analyses skills by
introducing:
1- advanced fundamental algorithms in
Bioinformatics;
2- their application in genome analyses;
3- recent knowledge acquired from genomes studies
and their perspectives.
Enjoy
this exiting course
and
your stay in Hong Kong