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Prevention of complications: Do not not lose sight of the risks Philippe Halban President, European Association for the Study of Diabetes www.easd.org [email protected] What are the major complications of diabetes? Cardiovascular Kidney (nephropathy) Retina (retinopathy) Nerves (neuropathy) Concern both Type 1 and Type 2 diabetes Cause great suffering (pain and quality of life) Premature death High costs to society Can diabetes be prevented? Focus on Type 2 (non-insulin-dependent) diabetes Getting the balance right: genes lifestyle Genes cannot change in a generation; lifestyle can! The risk factors: genes and lifestyle “good” genes healthy diet exercise no diabetes diabetes “diabetes” genes unhealthy diet sedentary lifestyle Strategies for prevention of Type 2 diabetes and its complications TODAY Screen population for early detection of those at highest risk (impaired glucose tolerance) TREAT SYMPTOMS + EDUCATE and SUPPORT Modify lifestyle: Light exercise Less fat - fewer calories Decrease risk of developing complications/delay onset (diabetes prevention studies in US and Europe show that this can work) BUT This is not a cure and does not prevent all complications and Major problem of compliance Strategies for prevention of Type 2 diabetes and its complications THE FUTURE GENETIC SCREENING High risk population gene therapy modify lifestyle medication PREVENTION AND CURE What patients with diabetes need and deserve Increased political and public awareness of the magnitude and severity of diabetes Increased focus on health education for improved lifestyle Increased spending on diabetes research in Europe