Download スライド 1 - Springer Static Content Server

Pathways possibly associated to narcolepsy:
lipid metabolism, membrane transport, signal transduction, signaling molecules and interaction, cell
growth and death, immune system, nervous system
Search databases; UCSC, KEGG, Gene Ontology
2018 candidate genes
SNPs with
P<0.01 in GWAS
SNP
gene
SNP
(P<0.01)
No
Out
50kb
50kb
Yes
more than
two SNPs with P<0.01
in GWAS
No
Extract SNP list
Yes
Consider LD and Extract SNP list
223 candidate SNPs
Online Resource 2 Process of extracting candidate SNPs
SNPs with 6.4×10-5 < P < 0.01 in the initial GWAS were applied as targets. Three
databases were used to extract genes associated to the pathways related to
narcolepsy in certain way. A total of 2,018 genes were picked up as candidate genes
and these genes were examined whether they had SNPs with 6.4×10-5 < P < 0.01
within 50kb upstream and downstream of the gene in the GWAS