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Transcript 
William S. Klug
Michael R. Cummings
Charlotte A. Spencer
Concepts of Genetics
Eighth Edition
Chapter 5
Chromosome Mapping in
Eukaryotes
Copyright © 2006 Pearson Prentice Hall, Inc.
Genes Linked on the Same
Chromosome Segregate
Together
Figure 5-1
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-1a
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-1b
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-1c
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-2
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-2-01
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-2ab
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-2a
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-2b
Copyright © 2006 Pearson Prentice Hall, Inc.
Crossing Over Serves as the
Basis of Determining the
Distance between Genes
during Chromosome
Mapping
Morgan and Crossing Over
Figure 5-3
Copyright © 2006 Pearson Prentice Hall, Inc.
Crossing Over Serves as the
Basis of Determining the
Distance between Genes
during Chromosome
Mapping
Sturtevant and Mapping
Figure 5-4
Copyright © 2006 Pearson Prentice Hall, Inc.
Single Crossovers
Figure 5-5
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-6
Copyright © 2006 Pearson Prentice Hall, Inc.
Multiple Exchanges
Figure 5-7ab
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-7a
Copyright © 2006 Pearson Prentice Hall, Inc.
Three-Point Mapping in Drosophila
Figure 5-8
Copyright © 2006 Pearson Prentice Hall, Inc.
Determining the Gene
Sequence during Mapping
Relies on the Analysis of
Multiple Crossovers
Determining the Gene Sequence
Method I
Figure 5-9
Copyright © 2006 Pearson Prentice Hall, Inc.
Determining the Gene Sequence
Method II
A Mapping Problem in Maize
Figure 5-10
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-10a
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-10b
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-11
Copyright © 2006 Pearson Prentice Hall, Inc.
Interference Affects the
Recovery of Multiple
Exchanges
As the Distance between
Two Genes Increases,
Mapping Experiments
Become More Inaccurate
Figure 5-12
Copyright © 2006 Pearson Prentice Hall, Inc.
RF= 0.5(1-e-m) x 100
m is the mean number of crossovers
Figure 5-13
Copyright © 2006 Pearson Prentice Hall, Inc.
Drosophila Genes Have
Been Extensively Mapped
(In fact, the Drosophila genome has now been
sequenced)
Figure 5-14
Copyright © 2006 Pearson Prentice Hall, Inc.
Crossing Over Involves a
Physical Exchange between
Chromatids
Figure 5-15
Copyright © 2006 Pearson Prentice Hall, Inc.
Recombination Occurs
between Mitotic
Chromosomes
Figure 5-16
Copyright © 2006 Pearson Prentice Hall, Inc.
Exchanges Also Occur
between Sister Chromatids
Figure 5-17
Copyright © 2006 Pearson Prentice Hall, Inc.
Lod Score Analysis and
Somatic Cell Hybridization
Were Historically Important
in Creating Human
Chromosome Maps
(These approaches still are
important)
Synteny testing
Fuse two cells
Figure 5-23
heterokaryon
synkaryon
Copyright © 2006 Pearson Prentice Hall, Inc.
Figure 5-24
Copyright © 2006 Pearson Prentice Hall, Inc.
Gene Mapping Is Now
Possible Using Molecular
Analysis of DNA
Gene Mapping Using Annotated
Computer Databases
Did Mendel Encounter
Linkage?
maybe ☺
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