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An Introduction to Bioinformatics Algorithms Conservation www.bioalgorithms.info ⢠Amino acid changes that tend to preserve the physico-chemical properties of the original residue ⢠Polar to polar ⢠aspartate glutamate ⢠Nonpolar to nonpolar ⢠alanine valine ⢠Similarly behaving residues ⢠leucine to isoleucine