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7 December 2011
Renal Physiology
Test # 3 Update on grading
Next Week in Physiology: Final Exams
Monday 9-noon
for 8:30 section
Tuesday 2-5
for 10:30 section
Wednesday 9-noon for 9:30 section
Friday Class: Lock in to Exam Day
See old tests for 20
minutes at start of
Friday’s class.
Your only access to
old tests.
a
Which segment
impermeable to water?
Which segment has
variable permeability to
water?
Which segments are
under hormonal control?
Reabsorption and secretion in
proximal tubule is NOT under
hormonal control.
Primary active transport of
Na+ establishes a gradient for
reabsorption of glucose,
amino acids, etc.
Reabsorption and secretion in
DCT & CD is under hormonal
control.
Hormones that act here:
ANH, ADH, Aldosterone.
Here, reabsorption of Na+ is
linked to the secretion of K+.
Transport Maximum and
Diabetes mellitus
Reabsorption and secretion in
proximal tubule is NOT under
hormonal control.
Primary active transport of
Na+ establishes a gradient for
reabsorption of glucose,
amino acids, etc.
Reabsorption and secretion in
DCT & CD is under hormonal
control.
Hormones that act here:
ANH, ADH, Aldosterone.
Here, reabsorption of Na+ is
linked to the secretion of K+.
Effect of Aldosterone: insertion
of more Na+K+ATPase into
basolateral membrane
Effect: Increase Na+ reab and Increase K+ Secretion
Figure 14.30
Cell in the adrenal
cortex that respond
to AII are also
receptors for plasma
K+ concentration.
Sodium reabsorption
and potassium
secretion are coupled.
Apply this
information to
each of the three
Test Beverages
used in the
Urinalysis Lab!
Effect of ADH: insertion of
more aquaporins in the
membranes
Effect: Increase H2O reabsorption
Normally, all14.31
filtered
Figure
bicarbonate is “reabsorbed”
Figure 14.32
This process is increased
during metabolic acidosis
Excess H+
eliminated
in urine
bound to
phosphate
buffer.
Figure 14.33
1.
2.
3.
4.
Filtration
Reabsorption
Secretion
Metabolism
Metabolism of
glutamine in tubular
cells generate
bicarbonate buffer.
This process is increased
during metabolic acidosis
Who Cares?
Loss of HCl in
vomitus would be
compensated by……..
Changes in
ventilation
after you
vomit?
Who Cares?
Father-in-law with emphysema
(respiratory case studies lab)
PaCO2 =30 mmHg,
plasma pH = 7.47
Hyperventilating: ventilation in
excess of metabolism to
compensate for loss of alveolar
surface area for diffusion of O2
Commensurate loss of CO2
RESPIRATORY ALKALOSIS
Renal compensation………
retain H+ and eliminate HCO3Review 3 previous slides.