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a Structures Coiled-coil structureknob in hole Source: Introduction to Protein Structure by Branden & Tooze Coiled-coil structure. Two a helices are interwined and gradually coil around each other. Source: Introduction to Protein Structure by Branden & Tooze Repetitive pattern of amino acids in a coiledcoil a helix. Source: Introduction to Protein Structure by Branden & Tooze Packing of hydrophobic side chains between the two a helices in a coiled-coil structure. Source: Introduction to Protein Structure by Branden & Tooze Salt bridge in a coiled-coil a helix. Source: Introduction to Protein Structure by Branden & Tooze “Knobs in holes” in a coiled-coil a helix. Source: Introduction to Protein Structure by Branden & Tooze Dimeric Rop molecule“knobs in holes” + “ridges in grooves” Source: Introduction to Protein Structure by Branden & Tooze Globin Domain Source: Introduction to Protein Structure by Branden & Tooze Ridge on groove Source: Introduction to Protein Structure by Branden & Tooze ridges & groovessurface of side chains of a helix Source: Introduction to Protein Structure by Branden & Tooze Helix packing by “ridges in grooves” Source: Introduction to Protein Structure by Branden & Tooze Sickle-cell hemoglobin Source: Introduction to Protein Structure by Branden & Tooze Hemoglobin molecule Source: Introduction to Protein Structure by Branden & Tooze Sickle-cell hemoglobin molecules polymerization. Source: Introduction to Protein Structure by Branden & Tooze