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UCL SCHOOL OF PHARMACY
BRUNSWICK SQUARE
Title of Project
Taste-masked nanofibres for paediatric drug delivery
Project Description
The effective delivery of medications to children remains a major challenge, not only because
of the distinct distribution profiles associated with this population but also due to issues of
acceptability and palatability that are closely associated with concordance. The problem
becomes exacerbated within the global perspective, with particular issues inclduing cost and
practicality of administration. Our hypothesis is that rapidly disintegrating dosage forms
(which ‘melt’ in the mouth) may be designed so as to simultaneously mask drug taste via
nanofiber incorporation. We believe that such a system is now feasible from an efficacy and
manufacturing perspective, as low-cost nanofibers provide a novel means of simultaneously
controlling release, taste and mouthfeel.
Here we use recent technology to produce
nanofibers on a realistic scale which may be incorporated into films disintegrating in the
mouth. We will also use our suite of taste assessment facilities to measure masking efficacy.
Main Methods and Techniques to be employed
Nanofibre production using pressurized gyration, in collaboration with Colleagues in the
Department of Mechanical Engineering (Professor Mohan Edirisinghe).
Formulation of
nanofibres into orally disintegrating dosage forms. Assessment of taste using a range of
systems ranging from electronic biosensor systems to human taste panels (Dr Catherine
Tuleu).
Person specifications
The successful applicant will be expected to have a UK Bachelor’s degree in Pharmacy,
Chemistry, Chemical Engineering or Mechanical Engineering, awarded with first or upper
second-class Honours, or an overseas qualification of an equivalent standard from a
recognised higher education institute, or a recognised taught Master’s degree.
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UCL SCHOOL OF PHARMACY
BRUNSWICK SQUARE
Please note that this studentship is limited to students with Home/ EU tuition fee status
and that we would like the successful candidate to commence the programme on the 1st
October 2016. The studentship will be funded for 48 months and the stipend rate will be at
least £16,057 pro rata.
How to apply
Applications must only include CV, personal statement plus the contact details of two
referees and should be sent to Mr Victor Diran ([email protected]).
For any academic queries please contact Prof Duncan Craig
(https://iris.ucl.ac.uk/iris/browse/profile?upi=DQMCR05) or Dr Catherine Tuleu
(https://iris.ucl.ac.uk/iris/browse/profile?upi=CTULE65).
Closing date of application is Thursday 30th June 2016 (5pm UK time).
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