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Molecular Mechanisms in Biology BMSC-GA 2004 Fall 2015 The goal of this course is to provide an in-depth understanding of the molecular mechanisms underlying key biological processes by examining the structure and mechanism of the macromolecules that govern those processes. 4 credit hours Lectures on Mon. and Wed., 10:30-12:00. Discussion session on Fri., 10:30-12:00. First class on Mon., Sept. 14th. Course director: Dr. Stevan Hubbard – Skirball 3rd floor, lab 14; 263-8938; [email protected] Suitable for 1st- or 2nd-year students Topics • Principles of protein structure and folding • Enzyme structure and mechanism • Structure-based drug design • Molecular machines • Membrane proteins • Chromatin structure and epigenetics • Protein-nucleic acid recognition • RNA structure, ribozymes and riboswitches • Ligand-receptor recognition • Protein-protein interactions in signal transduction • Protein-protein interactions in immune recognition • Introduction to x-ray crystallography and electron microcopy Instructors • Dr. Karim-Jean Armache • Dr. Joel Belasco • Dr. Stevan Hubbard • Dr. Xiangpeng Kong • Dr. Michelle Krogsgaard • Dr. Moosa Mohammadi • Dr. Alexander Serganov • Dr. David Stokes • Dr. Da-Neng Wang