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SECTION 9 SPATIAL PROBLEMS III: BREAKING SYMMETRY THE MODEL QUESTION 1 What is the critical value of kl/ks, above which the system is bistable? QUESTION 1 What is the critical value of kl/ks, above which the system is bistable? QUESTION2 Brefeldin A (BFA) is a drug that disrupts the Golgi apparatus by collapsing the compartments. How can you use this program to simulate recovery from BFA treatment. Can this system recover from BFA treatment? For what range of kl/ks? QUESTION3 We have seen in Question 1 that the cell would like kl/ks to be large in order to generate two distinct compartments. What happens to the system when kl/ks gets very large? Think in terms of the fluxes (the rate at which vesicles that bud from one compartment fuse to the other. What value of kl/ks optimizes the directional flow between the two compartments? HINT: Flux of vesicle A from S1 to S2 = fa1 = xua1*xu2 + yva1*yv2 fb1 = xub1*xu2 + yvb1*yv2 fa2 = xua2*xu1 + yva2*yv1 fb2 = xub2*xu1 + yvb2*yv1 QUESTION 1 QUESTION 2 QUESTION 3