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HESI ILSI Health and Environmental Sciences Institute HESI PROJECT COMMITTEE ON DOSE-DEPENDENT TRANSITIONS IN MECHANISMS OF TOXICITY NANCY G. DOERRER, MS HESI [email protected] SOT Risk Assessment Specialty Section Teleconference February 9, 2005 HESI ILSI Health and Environmental Sciences Institute Project Committee Leadership Chair: DR. WILLIAM SLIKKER, JR. US Food and Drug Administration National Center for Toxicological Research Vice Chair / Scientific Advisor: DR. KENDALL WALLACE University of Minnesota HESI ILSI Health and Environmental Sciences Institute Project History • 2001: Project Committee formed; objectives defined • 2002: Development of case examples to demonstrate dose-dependent transitions • 2003: Multi-stakeholder, multi-sector workshop to build consensus on principles and applications • 2004: TAAP publications • 2003-2005: Outreach HESI ILSI Health and Environmental Sciences Institute Project Committee Participation Government Participation: Agency for Toxic Substances and Disease Registry, National Institute of Environmental Health Sciences, US Environmental Protection Agency, US Food and Drug Administration Academic Participation: Clark University, University of Kansas Medical Center, University of Minnesota, University of North Carolina Industry: The Dow Chemical Company, DuPont Haskell Laboratory for Health and Environmental Sciences, Eastman Kodak Company Other Participants: CIIT Centers for Health Research, Gaylor and Associates, LLC, ILSI RSI HESI ILSI Health and Environmental Sciences Institute February 12-13, 2003, Workshop Washington, DC • Co-Sponsors: HESI, ATSDR, ACC, NIEHS, SOT, and US EPA, with additional support from Health Canada • Purpose: to examine approaches to doseresponse analysis, learn from the case study examples, and gather feedback on the impact of dose-dependent transitions on the risk assessment process. • Participation: approximately 50 invited scientists from government, academia, and industry HESI ILSI Health and Environmental Sciences Institute Workshop Organizing Committee Melvin Andersen (CIIT) Matthew Bogdanffy (DuPont) James Bus (Dow) Rory Conolly (CIIT) Raymond David (Kodak) Christopher DeRosa (ATSDR) Nancy Doerrer (HESI) John Doull (University of Kansas) William Farland (EPA) Penelope Fenner-Crisp (ILSI RSI) David Gaylor (Gaylor and Associates) Dale Hattis (Clark University) Gary Kimmel (EPA) Christopher Portier (NIEHS) Bernard Schwetz (FDA) R. Woodrow Setzer, Jr. (EPA) William Slikker, Jr. (FDA) Bob Sonawane (EPA) James Swenberg (University of NC) Kendall Wallace (University of MN) Mildred Williams-Johnson (ATSDR) HESI ILSI Health and Environmental Sciences Institute Publications Slikker, W., Jr., Andersen, M.E., Bogdanffy, M.S., Bus, J.S., Cohen, S.D., Conolly, R.B., David, R.M., Doerrer, N.G., Dorman, D.C., Gaylor, D.W., Hattis, D., Rogers, J.M., Setzer, R.W., Swenberg, J.A., Wallace, K., 2004a. Dosedependent transitions in mechanisms of toxicity. Toxicol. Appl. Pharmacol. 201, 203-225. Slikker, W., Jr., Andersen, M.E., Bogdanffy, M.S., Bus, J.S., Cohen, S.D., Conolly, R.B., David, R.M., Doerrer, N.G., Dorman, D.C., Gaylor, D.W., Hattis, D., Rogers, J.M., Setzer, R.W., Swenberg, J.A., Wallace, K., 2004b. Dosedependent transitions in mechanisms of toxicity: case studies. Toxicol. Appl. Pharmacol. 201, 226-294 HESI ILSI Health and Environmental Sciences Institute Outreach 2003: • Workshop, Society of Toxicology Annual Meeting, Salt Lake City, UT 2005: • February SOT/RASS Monthly Teleconference • SOT/RASS Meeting, March Annual Meeting • Poster, May FDA Science Forum • Poster, May EPA Science Forum • Session, November Annual Meeting of the American College of Toxicology, Williamsburg, VA