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ALLHAT Has the publication of ALLHAT influenced the sale of diuretics? ALLHAT Drug Utilization Data • The data source is IMS, Health • Since specific indication for drug use is unknown, the data represent all indications. • Approximately three-quarters of the use is for hypertension. This estimate is stable. • For any fixed drug combination, each individual agent is counted. Thus, many users are prescribed more than one drug. • Generic lisinopril became available in the Summer of 2002. ALLHAT Drug Utilization by Drug* -- All Indications -- 18000000 Total Prescriptions 16000000 Lisinopril** 14000000 12000000 HCTZ Amlodipine 10000000 8000000 6000000 4000000 2000000 0 Q1-02 Q2-02 Q3-02 Q4-02 Q1-03 Q2-03 Q3-03 Q4-03 Q1-04 Q2-04 *Source: IMS Health, National Prescription Audit PlusTM, 2003 **branded & generic ALLHAT Drug Utilization by Class -- All Indications -40,000,000 Diur Total ACEIs Total Total Prescriptions 35,000,000 30,000,000 CCBs Total 25,000,000 20,000,000 15,000,000 10,000,000 5,000,000 0 Q1-02 Q2-02 Q3-02 Q4-02 Q1-03 Q2-03 Q3-03 Q4-03 Q1-04 Q2-04 *Source: IMS Health, National Prescription Audit PlusTM, 2003