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Homeostasis • 5 minute poster • Work as a team to produce a poster of everything you can remember about homeostasis WITHOUT looking at your books End Water Balance • Lesson Learning Outcomes: Describe the role of the kidneys in water homeostasis Explain the role of ADH in water balance Increasing Difficulty Predict the effects of different drugs on the amount of urine produced Water gains and losses How is water gained? How is water lost? The Kidney • The kidneys have two jobs: – Water balance – Excretion • They can change the amount of urine you make Urine concentration • What do you think your urine would be like if you…. GO FOR A TEN MILE RUN ON A HOT SUNNY DAY? Urine concentration • What do you think your urine would be like if you…. DRINK A BOTTLE OF WATER IN 30 MINUTES? Urine concentration • What do you think your urine would be like if you…. EAT A REALLY SALTY MEAL? Urine concentration • What do you think your urine would be like if you…. WAIT FOR THE METRO FOR AN HOUR IN THE SNOW WITHOUT A COAT? Left hand page Right hand page Summarise the role of the kidneys in water balance Summary Water Balance __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ Drugs • Some drugs affect the way the body produces urine • This happened in the 90s (when I was in middle school) • WHY DID LEAH BETTS DIE? Left hand page Explain why Leah Betts died Summary Right hand page Water Balance __________________________________ __________________________________ Ecstasy __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ Why did Leah Betts die? • It was the first time she took ecstasy and it wasn’t contaminated • She wasn’t dancing so she didn’t dehydrate • She drank about 7 litres of water in a few hours • Water balance is controlled by a hormone call Antidiuretic hormone (ADH) • ADH makes the kidney tubules more permeable to water so more water can be reabsorbed into the blood and less urine is produced • Ecstasy makes ADH production occur even when it is not needed Drugs Name of Drug Caffeine Alcohol Ecstasy Affect on release of ADH Affect on the volume of urine produced Drugs! Name of Drug Affect on release of ADH Affect on the volume of urine produced Caffeine Suppresses ADH production Suppresses ADH production Increases ADH production Increases the amount of urine Greatly increases the amount of urine Reduces the volume of urine produced Alcohol Ecstasy Negative feedback Receptors in brain Detects increase Hypothalamus (brain) Sweat Gland brings about change (decrease) 37C Receptor in brain and skin Detects decrease Hypothalamus (brain) Muscle Shiver brings about change (increase) Left hand page Right hand page Summary Draw a negative feedback loop for water balance. Water Balance __________________________________ __________________________________ Ecstasy __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ Negative feedback and ADH __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________ __________________________________