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Alcohol-Related Problems in Special Populations: S. Pirzada Sattar, MD Creighton School Of Medicine Department of Psychiatry Copyright ALCOHOL MEDICAL SCHOLARS 1 Substance Use Disorders in Special Populations Geriatric population HIV+ , & Gay and lesbian groups African Americans & other minorities Immigrants Psychiatric patients Children & Youth Women Physicians Incarceration Homeless 2 Athletes Copyright Alcohol Medical Scholars Program DEFINITIONS Substance Use Disorders(SUDs) DEPENDENCE Tolerance Withdrawal Inability to cut down/control use Considerable time spent using/obtaining/recovering Important activities given up/reduced Use despite negative consequences ABUSE (less severe) Failure to fulfill role obligations Use in hazardous situations Recurrent, related legal problems 3 Copyright Alcohol Medical Scholars Program SUBSTANCE USE DISORDERS IN GERIATRIC PATIENTS 4 Copyright Alcohol Medical Scholars Program Substance Use Disorders (SUDs) in Geriatric Patients Are Often Overlooked Substance users stereotyped as young Physicians miss substance use 5 Copyright Alcohol Medical Scholars Program Geriatric Patients with SUDs are Often Evaluated by Physicians Frequent evaluation an opportunity to screen Higher rates of SUDs in medical facilities Substance use complicates medical illnesses 6 Copyright Alcohol Medical Scholars Program Increased Substance Use Effects in Geriatric Patients Increased BAC because: • Decreased lean body mass • Decreased total body water • Decreased gastric alcohol dehydrogenase Alcohol and drugs more intoxicating in geriatric patients 7 Copyright Alcohol Medical Scholars Program Description of Alcohol Use Disorders in Geriatric Patients: Prevalence 16% Men > 2 drinks per day, 15% Women > 1 drink per day Up to 31% men, 21% women > 3 drinks daily in retirement communities Up to 21% alcohol dependence in medical patients 8 Copyright Alcohol Medical Scholars Program Alcohol Use Disorders (AUDs): Early Onset (< Age 60) About 2/3 of geriatric AUDs Greater financial, legal and social problems than later onset Heavier drinkers than later onset patients 9 Copyright Alcohol Medical Scholars Program AUDs: Late Onset ( > Age 60) About 1/3 of geriatric AUDs Aging social drinkers more intoxicated with same dose Cognitive disorder in heavy drinkers Social drinkers who increase drinking after losses 10 Copyright Alcohol Medical Scholars Program I. Medical Complications of Alcohol in Geriatric Patients Cirrhosis: 60% 1 year death rate > age 60 vs. 7% in younger patients Heart Effects • Women more susceptible • Alcoholic women 4 X coronary artery disease vs. non-alcoholic women • Atrial fibrillation common, “holiday heart” increases risk • Increased stroke risk 11 Copyright Alcohol Medical Scholars Program II. Medical Complications Increase in cancers of liver, esophagus, nasopharnx and colon Thrombocytopenia, macrocytosis 12 Copyright Alcohol Medical Scholars Program III. Medical Complications Neurologic • Increased dementia, Wernicke’s encephalopathy, Korsakoff’s psychosis Psychiatric • Alcohol-induced mood disorder • Pseudodementia from mood disorder • Suicide 13 Copyright Alcohol Medical Scholars Program Other SUDs Less data than AUDs Low prevalence of illicit drug use • Few IV drug users survive • Reduced access to illicit substances High prevalence of prescription drug use disorders • 25% using psychotropic medications • This includes benzodiazepines and opioids 14 Copyright Alcohol Medical Scholars Program Importance of Physician Screening Medical complications Doctors in an important position to intervene 15 Copyright Alcohol Medical Scholars Program DSM-IV Criteria for Substance Dependence Maladaptive pattern and 3 or more of the following in a 12 month period: Tolerance (often reduced in geriatric patients). Withdrawal (often delayed, with mental status changes in geriatric patients). Greater amount of use or longer duration than expected. Unsuccessful efforts to reduce use. Large amount of time obtaining, using and recovering from use. Important activities reduced or given up. Continued substance use despite its aggravation of physical or psychological problem. 16 Copyright Alcohol Medical Scholars Program DSM-IV Criteria for Substance Abuse • • • • Maladaptive use and 1 of the following in 12 month period: Failure to fulfill obligations at work school or home. Recurrent use when physically hazardous. Recurrent related legal problems. Continued use despite recurrent social or legal problems. 17 Copyright Alcohol Medical Scholars Program State Markers that Suggest Alcoholism • • • Gamma-glutamyl transferase (GGT): Sensitivity of 70% to 80% if 6-8 drinks per day consumed Mean corpuscular volume (MCV) greater than 90 cubic microns consistent with alcohol dependence Carbohydrate deficient transferrin (CDT): Social over 14 units/liter and alcohol dependence over 20-30 units/liter 18 Copyright Alcohol Medical Scholars Program Questionnaires that Raise Suspicion of Alcohol Abuse or Dependence • MAST-G is unique in that it is specific to geriatric alcohol use disorders. • AUDIT is comprehensive. • CAGE and TWEAK are quick but have limited sensitivity and specificity. 19 Copyright Alcohol Medical Scholars Program Assessment of Drinking 2 2 1 1 TWEAK: - T (tolerance) “How many drinks can you hold?” - W (worried) “Have close friends or relatives worried or complained about your drinking in the past year?” - E (eye opener) “Do you sometimes take a drink in the morning when you first get up?” - A (amnesia) “Has a friend or family member ever told you about things you said or did while drinking that you could not remember?” - K (cut town) “Do you sometimes feel the need to cut down on your drinking?” 1 ___ 3 risky drinking 20 Copyright Alcohol Medical Scholars Program Screening for SUDs other than AUDs Methods less developed than for AUDs Signs for concern (not specific) include: • doctor shopping • drug-seeking behavior • decreased motivation • trouble sleeping • poor self care 21 Copyright Alcohol Medical Scholars Program Treatment of SUDs Identification Intervention Detoxification Rehabilitation 22 Copyright Alcohol Medical Scholars Program Identification Doctor’s office, clinic and hospital extremely important sites for identification 23 Copyright Alcohol Medical Scholars Program Intervention in Geriatric patients • Involve adult family members. • Denial by family and peers. • Reduced mobility. • Losses and social isolation. 24 Copyright Alcohol Medical Scholars Program Brief Intervention • Two to three 10-15 minute counseling sessions • Identify problem, consequences and formulate treatment plan. • Non-confrontational and supportive. • Tailored to individual needs and goals. 25 Copyright Alcohol Medical Scholars Program I. Alcohol Detoxification Concerns in Geriatric Patients Confusion (rather than tremor) early withdrawal sign Duration of withdrawal/hallucinosis increased Rule out DTs in confused elderly Replace electrolytes and nutrients Short acting benzodiazepines (lorazepam) 26 Copyright Alcohol Medical Scholars Program II. Alcohol Detoxification Concerns in Geriatric Patients Severe withdrawal or medical illness managed inpatient Otherwise outpatient with family support Monitor symptomatology with Clinical Institute Withdrawal Assessment for Alcohol (CIWAs) 27 Copyright Alcohol Medical Scholars Program General Overview of Alcohol Detoxification Supportive treatment Benzodiazepine taper 28 Copyright Alcohol Medical Scholars Program Opioid Detox Supportive Treatment Medication • Clonidine • Methadone taper 29 Copyright Alcohol Medical Scholars Program I. Rehabilitation Strategies for Geriatric Patients Psychotherapy • Individual for substance use and social needs from losses and isolation • Group, family and network therapy for damage to family and peer relationships from substance use. 30 Copyright Alcohol Medical Scholars Program II. Rehabilitation Strategies for Geriatric Patients Optimized by age-specific treatment • Must fill the time formerly spent using substances • Senior centers often have alcoholics anonymous (AA) groups and support socialization 31 Copyright Alcohol Medical Scholars Program Pharmacotherapy in Rehabilitation: A Limited Role Naltrexone reduces alcohol reinforcing effects but does not clearly promote abstinence, monitor liver transaminases Disulfiram problematic with potential drug interactions and co-morbid medical conditions Acamprosate may modestly increase abstinence rates but GI upset, FDA approval pending 32 Copyright Alcohol Medical Scholars Program Alcohol and Drug Misuse in HIV+ and Gay and Lesbian Populations Copyright ALCOHOL MEDICAL SCHOLARS 33 Prevalence Approximately 1 million people have contracted HIV since 2001 Half have died >40% African American >20% Hispanics 24% of HIV+ were IV drug users 10% reported same sex practices 34 Copyright Alcohol Medical Scholars Program Prevention requires: Greater tolerance, assessment, testing Community resources & outreach Drug abuse treatment Harm reduction, e.g. Needle exchange programs, methadone, buprenorphine etc. Medical and psychiatric treatment 35 Copyright Alcohol Medical Scholars Program Alcoholics Anonymous Most cities have gay/lesbian AA meetings Clients may need to be reminded that AA is not specifically focused on religion Extending the powerlessness over alcohol concept to being powerless over being gay may be helpful 36 Copyright Alcohol Medical Scholars Program Recommendations Screen IV drug users & gay and lesbian clients for alcohol abuse and dependence HIV + may be referred to specific treatment centers 37 Copyright Alcohol Medical Scholars Program Substance Use Disorders in African Americans 38 Copyright Alcohol Medical Scholars Program Goal of this section Rare data Policy/planning Minorities and immigrants are different: -traditional use of drugs in place or culture of origin -traumas suffered by Blacks and other minorities 39 Copyright Alcohol Medical Scholars Program Minorities discussed: African American Native American Hispanics Asian Americans Pacific Islanders 40 Copyright Alcohol Medical Scholars Program Long history Marijuana and south Sahara 41 Copyright Alcohol Medical Scholars Program Exposure in the New World Patent medicine Syringe development Yet, use less common 42 Copyright Alcohol Medical Scholars Program 1940’s: Heroin Cough syrups Prescription drugs 1960’s: Marijuana 1990’s Cocaine 2000’s Methamphetamine 43 Copyright Alcohol Medical Scholars Program Major proportion of soldiers are from minorities Easy access to alcohol, ? Drugs Bring experiences home, e.g. PTSD 44 Copyright Alcohol Medical Scholars Program Racial integration (hallucinogens) Widespread cocaine use Gangs/crack -interdiction -combinations with alcohol and heroin 45 Copyright Alcohol Medical Scholars Program Alcohol White Black Hispanic Any type of drug White Black Hispanic 20.4 14.7 19.9 9.2 8.6 9.2 35+ 65.6 49.6 49.8 66.0 55.7 50.6 54.3 42.0 44.0 17.0 15.7 10.9 8.8 Type of drug Age group 26-34 12-17 18-25 2.9 3.8 1.5 10.6 5.7 46 Copyright Alcohol Medical Scholars Program Age group Type of drug 12-17 18-25 26-34 35+ Marijuana White Black Hispanic 7.3 7.3 6.9 14.4 13.9 8.3 6.6 9.2 3.6 1.9 3.3 1.0 Cocaine White Black Hispanic 0.5 1.1 1.1 2.3 3.1 2.1 1.3 0.6 1.4 0.4 0.6 0.6 47 Copyright Alcohol Medical Scholars Program Education: Family: -Schooling was denied to Blacks -Current education -?cohesiveness -Home supervision -Minority youth/single household Religion: Role of Religion for minorities (then & now) 48 Copyright Alcohol Medical Scholars Program Better screening and diagnosis Coordination schools/local organizations Culturally sensitive programs Involvement of religion and clergy education 49 Copyright Alcohol Medical Scholars Program Summary Discussion of historical and recent patterns. Areas of probable vulnerabilities, e.g. “acculturation stress”. Treatment options 50 Copyright Alcohol Medical Scholars Program Substance Abuse in Psychiatric Patients 51 Copyright Alcohol Medical Scholars Program Substance Abuse in Psychiatric Patients Prevalence Commonly abused substances Increases morbidity and mortality Treatment is available and effective Long term approach required 52 Copyright Alcohol Medical Scholars Program Alcohol-Related Problems in Special Populations: YOUTH and WOMEN Copyright ALCOHOL MEDICAL SCHOLARS 53 Drinking Rates in Youth 12th Graders 100% 75% 50% 25% 0% Ever Drank Been Drunk >5 Drinks Daily Drinking 54 Copyright Alcohol Medical Scholars Program Features of Drinking in Youth Prognosis Drink < age 14: risk of alcohol dependence Typical experimentation sequence: Cigarettes or Alcohol Marijuana Other drugs 55 Copyright Alcohol Medical Scholars Program Assessing Drinking in Youth Red flags: Change in peers Family problems Grades drop Mood swings Common consequences: Accidents “3-Ds”: driving, dating, & drug related problems Uncommon problems: Severe withdrawal symptoms Liver problems 56 Copyright Alcohol Medical Scholars Program Assessing Drinking in Youth 2 2 1 1 TWEAK: - T (tolerance) “How many drinks can you hold?” - W (worried) “Have close friends or relatives worried or complained about your drinking in the past year?” - E (eye opener) “Do you sometimes take a drink in the morning when you first get up?” - A (amnesia) “Has a friend or family member ever told you about things you said or did while drinking that you could not remember?” - K (cut town) “Do you sometimes feel the need to cut down on your drinking?” 1 ___ 3 risky drinking 57 Copyright Alcohol Medical Scholars Program Youth: Treatment Formats Multi-systemic treatments Minnesota model Therapeutic communities Cognitive-behavioral Groups Brief intervention 58 Copyright Alcohol Medical Scholars Program Youth: Treatment Pathways to success 1. Traditional routes 2. Early individuation 3. Family involvement Outcome Treatment helps Inpatient = Outpatient 50-80% relapse in 1st year after treatment 59 Copyright Alcohol Medical Scholars Program Women: Epidemiology Women Any alcohol in past year 62% Men 83% Has met Alcohol Abuse criteria 6% 13% Has been Alcohol Dependent 8% 20% 60 Copyright Alcohol Medical Scholars Program Women & Heavy Drinking Risk of health problems: Alcohol-related liver disease, hepatitis, infections, anemia STDs, UTIs, reproductive organ problems, breast cancer Violence victimization risk Neurocognitive effects 61 Copyright Alcohol Medical Scholars Program Alcohol & Pregnancy Prevalence 16-35% of pregnant women drink 4% drink frequently or heavily Fetal alcohol syndrome (FAS) 1. Facial dysmorphia 2. Growth deficiency 3. CNS deficits 62 Copyright Alcohol Medical Scholars Program Women: Detection Wide variability Social risk factors: Low vocational skills and education Substance use disordered partner Social isolation Screening tools: TWEAK AUDIT-C 63 Copyright Alcohol Medical Scholars Program Women: Treatment Issues Barriers External Internal Optimal treatment for women Reduce barriers Combine with obstetrics or other healthcare Women-only v. mixed setting 64 Copyright Alcohol Medical Scholars Program SUBSTANCE USE DISORDERS IN PHYSICIANS S. Pirzada Sattar, MD School of Medicine “WHY SHOULD I STAY AWAKE?” It might be my colleague It might be my patient It might be me 66 Copyright Alcohol Medical Scholars Program KEY POINTS SUDs similar to the general population Benzodiazepines and opioids higher Identification is often difficult and delayed Treatment outcomes are often better Impaired Physician Programs are helpful 67 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY VERY VARIABLE!!!! Population studied Methods used Terminology Diagnostic criteria Changes over time? Concern about anonymity 69 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY General Similar rates of SUDs to general population 8-14% Less SUDs compared to other occupations Roofers, painters Increased rates of use & SUDs with: Benzodiazepines Prescription opioids 70 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY Medical Students Use begins prior to medical school Types of drugs same as general pop. Alcohol use & dependence variable Drug use and dependence less 71 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY Residents Rates of dependence:10-14% Alcohol & illicit drug use begins prior Benzo & opioid use begins during Self-treatment Self-prescribed 72 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY Practicing Physicians Prevalence of dependence: 8-14% Still means 60-75,000 affected M.D.s in U.S.!!!! Use & misuse of prescription opioids & benzodiazepines up to 5Xs higher 73 Copyright Alcohol Medical Scholars Program EPIDEMIOLOGY By Specialty HIGHEST Emergency Medicine Psychiatry LOWEST OB-GYN Pathology Radiology Pediatrics Anesthesiology 74 Copyright Alcohol Medical Scholars Program REASONS FOR USE Recreational Seen more in medical students Performance Enhancement Seen more in Emergency Medicine Self-medication (pain, anxiety, “stress”) Seen more in residents & attendings 75 Copyright Alcohol Medical Scholars Program PROGRESSION Family Community Finances Spiritual/emotional Physical health Job performance Often one of the last things affected 76 Copyright Alcohol Medical Scholars Program CONTRIBUTING FACTORS Family History Personality characteristics Health/lifestyle Stress??? Availability??? 77 Copyright Alcohol Medical Scholars Program IDENTIFICATION Urine drug screening Employment/school application Physician screening Impaired Physicians Programs Reporting 78 Copyright Alcohol Medical Scholars Program “WARNING SIGNS” Isolation Friction with colleagues Disorganization Inaccessibility Frequent absences Rounding on patients at odd hours Inappropriate or forgotten orders Slurred speech during off-hours calls Prescriptions for family members OD or suicide attempt 79 Copyright Alcohol Medical Scholars Program WHY THE DELAY IN DETECTION? Independence “Malignant denial” “I can take care of myself” “Knowledge is protective” Fear of consequences “Conspiracy of silence” 80 Copyright Alcohol Medical Scholars Program “CONSPIRACY OF SILENCE” Reputation Financial Fear & intimidation Professional pride 81 Copyright Alcohol Medical Scholars Program REPORTING Ethical obligation Disabled Doctors Act Federal law Requirements vary by state Protection from law suit varies 82 Copyright Alcohol Medical Scholars Program TREATMENT THE GOOD NEWS!!! Variable data Most show better outcomes 70-90% “success rate” • little correlation with substance • little correlation with specialty 83 Copyright Alcohol Medical Scholars Program TREATMENT Goals Abstinence Acceptance of chronic disease concept Identification of triggers Development of non-chemical coping skills 84 Copyright Alcohol Medical Scholars Program TREATMENT Key Factors For Success Duration of aftercare Physician’s Health Program involvement Family involvement 12-Step involvement Witnessed urinalysis Contingency contract 85 Copyright Alcohol Medical Scholars Program TREATMENT Stumbling Blocks Uniqueness Role-reversal Over-identification w/ performance Identification (by treatment provider) Medical knowledge 86 Copyright Alcohol Medical Scholars Program TREATMENT Physician-specific In-Patient Talbott, Farley 12-Step “Caduceus meetings” Pros & Cons Combined approaches 87 Copyright Alcohol Medical Scholars Program “RE-ENTRY” Most return to practicing medicine Change to a less high-risk specialty Imposed prescribing restrictions Altered work schedule Specialization in addictions 88 Copyright Alcohol Medical Scholars Program “PREVENTION” Medical school policies Medical school education State Impaired Physicians Programs • Protect the public • Provide “rehabilitation” (vs punishment) JCAHO-mandated hospital programs 89 Copyright Alcohol Medical Scholars Program KEY POINTS A Review SUDs similar to the general population Benzodiazepines and opioids higher Identification is often difficult and delayed Treatment outcomes are often better Physician Rehab Programs are our friends 90 Copyright Alcohol Medical Scholars Program WHERE TO GET HELP State Agency # School Resources # Your email address 91 Copyright Alcohol Medical Scholars Program NURSES Rates similar to general population Higher use of benzodiazepines & opioids more parenteral use Higher in emergency room & critical care Especially difficult to monitor Watch for diversion 92 Copyright Alcohol Medical Scholars Program DENTISTS Less good data More use of inhaled anesthetics Possibly higher opioid use and SUDs Related to higher suicide rate? 93 Copyright Alcohol Medical Scholars Program PHARMACISTS Estimates of dependence: 10-18% Less parenteral use @ 50% have used CS w/o script @ 20% on regular basis primarily self-medication @ 60% of students have used CS w/o script @ 40% on regular basis primarily recreational 94 Copyright Alcohol Medical Scholars Program VETERINARIANS Little good data More Ketamine use Other higher-potency opioids Inhaled anesthetics 95 Copyright Alcohol Medical Scholars Program Substance Use In Athletes S. Pirzada Sattar, MD Developed for the Alcohol Medical Scholars Program Copyright ALCOHOL MEDICAL SCHOLARS 96 INTRODUCTION Major problems facing sport today Growing attention Deaths of elite athletes Increasing attention of media Contrary to the ethical principles of athletic competition Wide spread among athletes 97 Copyright Alcohol Medical Scholars Program DRUGS MISUSED BY ATHLETES • Therapeutic drugs OTCs, diuretics, opioids, beta-blockers, etc. Performance enhancing drugs Amphetamines, ephedrine, caffeine, anabolic steroids, growth hormone, etc. Drugs typically misused Alcohol, nicotine, marihuana, cocaine, etc. 98 Copyright Alcohol Medical Scholars Program GOALS Historical perspective Factors influencing athletes to use drugs Types of drugs athletes useconsequences and myths Preventing and treating drug use in athletes 99 Copyright Alcohol Medical Scholars Program Historical perspective Ancient civilizations Mushrooms, herbs, liquor 19th Century Alcohol, caffeine, nitroglycerine, opium, strychnine, trimethyl World War II Amphetamines, testosterone 100 Copyright Alcohol Medical Scholars Program Historical perspective Post war era Amphetamines continue Anabolic steroids Newer agents Blood doping Erythropoietin Growth hormone 101 Copyright Alcohol Medical Scholars Program Currently prohibited by IOC Drugs Stimulants, opioids, anabolic agents, diuretics, peptide hormones Methods Blood doping, artificial oxygen administration, plasma expanders, pharmacological, chemical and physical manipulation In certain circumstances Alcohol, cannabinoids, local anesthetics, blockers 102 Copyright Alcohol Medical Scholars Program What factors influences athletes? Belief that competitors take drugs Determination to do anything to win Pressures from coaches, parents, peers Community attitudes and expectations Financial rewards Media influence Belief of enhanced performance 103 Copyright Alcohol Medical Scholars Program THERAPEUTIC DRUGS OTCs NSAIDs, laxatives, ephedrine, analgesics, weight loss meds, corticosteroids, local anesthetics Low potential for misuse Increased risk of further injury, GI bleed, anemia, eating disorders 104 Copyright Alcohol Medical Scholars Program THERAPEUTIC DRUGS Diuretics Rapid weight loss Boxing, wrestling, judo Excretion or dilution of illegal substances Overall negative impact on performance Dehydration, hypotension, muscle cramps, electrolyte imbalance 105 Copyright Alcohol Medical Scholars Program THERAPEUTIC DRUGS Opioids Prescription pain killers most common Allow performance while injured 75% used after injury only Increased risk of further injury, dependence, drowsiness, mental clouding; in high doses: respiratory depression, hypotension 106 Copyright Alcohol Medical Scholars Program THERAPEUTIC DRUGS Beta-Blockers Anti-tremor, anxiolytic effect Shooters, ski jumpers, archery Negative effect on endurance Depression, bronchospasm, fatigue 107 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS CNS Stimulants Amphetamines • Delay fatigue, increase alertness, enhance speed, power, endurance, concentration Hypertension, angina, vomiting, abdominal pain, cerebral hemorrhage, dependence, death 108 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS CNS Stimulants Caffeine • Shortened reaction time, improved concentration, diuresis • Glycogen sparing leading to delayed fatigue • > 12 ug/mL is a positive urine per IOC Dyspepsia, cardiac damage, combination with other stimulants (e.g. ephedrine) may be fatal 109 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Systemic stimulants Adrenalin • In local anesthetics Ephedrine and pseudoephedrine • Cold and allergy remedies Phenylpropanolamine • Diet pills Similar effects to the amphetamines in high doses 110 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Anabolic androgenic steroids Derivatives of testosterone First use generally later than other drugs Drug and method sought for maximum anabolic and minimum androgenic properties Sprinting, weight lifting, body building Acne, abnormal LFTs, feminization, virilization, premature closure of the epiphysial plates, behavioral changes “roid rage”, CVAs, cardiomyopathy 111 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Beta 2 agonists Isoproterenol, epinephrine, norepinephrine Sympathomimetic amines, anabolic properties Cardiac arrhythmias in overdose, headaches Peptide hormones: HCG Increases testosterone Maintains testicular volume with anabolic steroid use Ovarian cysts 112 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Pituitary and synthetic gonadotropins Increases testosterone, anti- estrogenic Ovarian cysts Corticotropins Increase testosterone Rare and related to excess corticosteroidspituitary suppression, ¯ immunity, osteoporosis, hyperglycemia 113 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Growth hormone Increase muscle mass & decrease fat mass Gigantism, acromegaly, hypothyroidism, cardiac disease, myopathies, arthritis, diabetes mellitus, impotence, osteoporosis 114 Copyright Alcohol Medical Scholars Program PERFORMANCE ENHANCING DRUGS Erythropoietin (EPO) Stimulates RBC production Increases oxygen carrying capacity CVAs Blood doping RBC transfusion, artificial oxygen carriers Increases oxygen carrying capacity Allergic reactions, sludging of blood 115 Copyright Alcohol Medical Scholars Program FOOD SUPPLEMENTS Viewed as legal means of gaining edge 76-100% of athletes use vs. 50% general population May or may not contribute to enhanced performance Creatine, colostrum, antioxidants, sodium bicarbonate, vitamins, proteins, amino acids Adverse effects not investigated 116 Copyright Alcohol Medical Scholars Program TYPICAL DRUGS OF MISUSE Most common: marijuana, cocaine, alcohol Generally have negative effect on performance Substance misuse same in college athletes vs. nonathletes Decrease in use of marijuana, amphetamines and cocaine, but increase in smokeless tobacco use, 1985-1996 Most drugs first used in junior or senior high school (for recreation not performance) 117 Copyright Alcohol Medical Scholars Program TYPICAL DRUGS OF MISUSE Alcohol Most frequently used Negative impact on reaction time, handeye coordination, balance, strength Excessive heat production and dehydration Cardiovascular and GI complications, nutritional deficiencies, dependence 118 Copyright Alcohol Medical Scholars Program TYPICAL DRUGS OF MISUSE Cocaine Minimal performance enhancing effect Heightened arousal and increased alertness with low doses Over confidence leading to increased risk of injury MI, CVA, seizures, arrhythmias, dependence 119 Copyright Alcohol Medical Scholars Program TYPICAL DRUGS OF MISUSE Cannabinoids Most frequent illegal drug used in the US Male athletes have higher incidence than nonathletic peers (opposite for females) Initial use in high school Psychomotor impairment, distorted perception, amotivational syndrome; decreased testosterone with long-term use 120 Copyright Alcohol Medical Scholars Program TYPICAL DRUGS OF MISUSE Nicotine Majority use in form of smokeless tobacco Males >> females 52% of baseball players, 26% of varsity football players used smokeless tobacco (early 1990s California college survey) Highest risk for baseball players Cardiovascular and pulmonary disease, oral cancers, dependence 121 Copyright Alcohol Medical Scholars Program PREVENTION AND TREATMENT Drug testing Commonplace in amateur and professional sports 65% of college athletes agree with testing 37% agreed that positive should result in disqualification 67% of college athletes believe that drug testing deters drug use 122 Copyright Alcohol Medical Scholars Program DRUG PROGRAMS Administered by leagues and associations (NCAA, NFL, NBA) Responsible for relevant events, fairness, quality of competition, safety, image of their athletes and events Deter use by testing and discipline Some include evaluation and treatment Coaches can discourage use 123 Copyright Alcohol Medical Scholars Program DRUG PROGRAMS Identify individuals with drug problem to facilitate treatment Keys to successful drug program: Inclusion of all involved parties Reliable and sensitive testing program Consistent discipline Evaluation of effectiveness Confidentiality Early prevention 124 Copyright Alcohol Medical Scholars Program CHALLENGES Most drugs not prescribed Viewed as essential for success Easy access to drugs Physician dilemma/role Monitoring side effects Why?, discuss pro/cons, appraisal, explore options Need for collaboration 125 Copyright Alcohol Medical Scholars Program SUMMARY Substance use in athletes dates to ancient times Multiple factors why athletes use drugs Types of drugs used range from therapeutic and performance enhancing to typical drugs of misuse Programs are in place to address drug use in athletes 126 Copyright Alcohol Medical Scholars Program