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Fig. A
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ScanYear:2005
ScanYear:2006
ScanYear:2007
ScanYear:2008
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PC2
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Color Key
and Histogram
50
30
Up-regulated mRNAs
Down-regulated mRNAs
Both up- and down-reg.
0 10
Count
Fig. B
KEGG term
enrichment
among:
GSE19407
1
2.5
4
Value
1
DNA
replication
2
Purine
metabolism
3
Pentose
phosphate pathway
4
Sulfur
metabolism
5
Arachidonic
acid metabolism
6
Glutathione
metabolism
7
Metab.
of xenobiotics by cytochrome P450
8
Retinol
metabolism
9
Steroid
hormone biosynthesis
10
Propanoate
metabolism
11 acid metabolism
Fatty
12
Tryptophan
metabolism
13
Phenylalanine
metabolism
14
Tyrosine
metabolism
15
Histidine
metabolism
16
O-glycan
biosynthesis
17
Ribosome
18
Proteasome
19 signaling
WNT
0.6
0.5
V5
0.7
V4
0.8
V3
0.9
V2
1.0
V1
20
Sphingolipid
metabolism
Fig. C
Human
COPD
14
Guinea pig
CSCH
6
P<0.01
12
Human
COPD
15
Lysosome ()
Chemokine signaling ()
Cytokine-cytokine receptor interaction ()
Keratan sulfate biosynthesis ()
Complement and coagulation ()
Spliceosome ()
N-Glycan biosynthesis ()
Biosynthesis of unsaturated FA ()
Chondroitin sulfate biosynthesis ()
Tight junction ()
ErbB signaling ()
Alpha-Linolenic acid metabolism ()
Guinea pig
CS
5
P<0.05
12
Spliceosome ()
Drug metabolism ()
Arginine and proline metabolism ()
Lysosome ()
ErbB signaling ()
RNA polymerase ()
Gap junction ()
Pyrimidine metabolism ()
Chemokine signaling ()
Inositol phosphate metabolism ()
Chondroitin sulfate biosynthesis ()
Phosphatidylinositol signaling ()