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Andrzej M. Belzowski (Prof. M.A. Jones) www.chem.ilstu.edu/stem Detection of reactive nitrogen species within L. tarentolae induced by carbaporhyrin ketal “STEM summer research was a great experience of what real life research is all about.” -A. Belzowski At right: L. tarentolae with a nitric oxide specific fluorescent probe, using confocal microscopy and, to the far right, the same cell in transmission mode. Andrzej practicing protein assay. This project was a part of an effort to find a treatment for leishmaniasis, diseases caused by Leishmania parasites. The carbaporphyrin dimethyl ketal was tested for its ability to induce reactive nitrogen species (RNS), such as nitric oxide. The production of nitric oxide induced by carbaporphyrin ketal in L. tarentolae was detected by confocal microscopy. Work to detect nitric oxide by EPR is still in progress. Detection of induced nitric oxide paves a way for new class of drug treatments for leishmaniasis.