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Domain Organization of Multi-Drug Related Protein (MRP1)
SIGMA-ALDRICH
Domain Organization of Multi-Drug Related Protein
(MRP1)
MRP1 is a representative of the second major subfamily, MRP, of multidrug ABC transporters.
MRPs have an extra TMD and have the general form of TMD0(ABC-TMD)2. The diagram
shows the transporter as an intrinsic membrane protein.
References
Kruh, G.D., et al. MRP subfamily transporters and resistance to anticancer agents. J.
Bioenerg. Biomembr., 33, 493-501 (2001).
Borst, P., et al. A family of drug transporters: the multidrug resistance-associated proteins. J.
Natl. Cenacer Inst., 92, 1295-1302 (2002).
Rosenberg, M.F., et al. The structure of the multidrug resistance protein 1 (MRP1/ABCC1),
crystallization and single-particle analysis. J. Biol. Chem., 276, 16076-16082 (2001).
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