Download Carbon Nanotube In Biology

Carbon Nanotube In Biology
Lawanya Raj Ojha
Graduate Student
Department of Chemistry, OSU, Stillwater
1
Abstract
Carbon nanotubes have many interesting and unique properties
potentially useful in a variety of biological and biomedical systems
and devices. Significant progress has been made in the technical
barriers toward applications, especially on issues concerning the
aqueous solubility and biocompatibility of carbon nanotubes.
2
Background and Introduction
Carbon Nanotubes (CNTs)

Allotropes of carbon.

Well ordered, hollow cylindrical shape, length from several hundred
nm to µm, diameter of 0.4-2 nm (SWANT) and 2 - 100nm (MWNT)

Unique properties- High surface area, High mechanical strength,
Rich electronic properties, Excellent Chemical and thermal Stability.

Several applications due to their unique properties

Application in biology:- Drug delivery, biosenser, antigen
recognition, DNA hybridization
3
Current Research and Application

The ability of f-CNT to penetrate into the cells offers the potential of
using f-CNT as a vehicles for the delivery of small drug molecules

Binaco et. al. developed a new strategy for the multiple
functionalization of CNT with amphotericin B (AmB) and fluorescein.

The antibiotic linked to the nanotube was easily internalized into the
mammalian cells without toxic effect in comparison the antibiotic
incubated alone.
4
Current Research and Application
5
Bianco et.al., Angew. Chem. Int. Ed. 2005, 44, 6358
Current Research and Application

Ammonium functionalized CNT for their ability to form supra
molecular complex with nucleic acid by electrostatic interactions. This
CNT-DNA complex acts as a nonviral vector to deliver plasmid DNA
into the cell.
Singh et. al., J. Am. Chem. Soc. 2005, 127, 4388

Dai and colleagues used a simple non covalent route to attach a
reactive molecules to sidewalls of SWNT. This reactive molecule could
the be used to attach to the wall of these tubes. This related work is of
interest to the development of biosensor based on nanotubes.
Green et. al., J. Am. Chem. Soc. 2002,124, 12664
6
Current Research and
Application

Z. Heng et al. discovered the
DNA wrapped CNT.

Biosensor
DNA Wrapped CNT- new
type of optical sensor in living
system.
7
Current Research and Application

Lieber group have shown that SWNT are ideal probe tips for AFM because
of their small diameter.
Nature, 1998, 394, 53

CNTs also sustain the osteoblast growth and bond formation, and thus
represent a potential technological advance in bone bioengineering.
Haddon et. al. Nano Lett. 2006, 6 , 566

Recent development of modification of CNT by some biomoleculescarbohydrates, protein, Nucleic Acid – another solid step toward the use of
carbon nanotubes in biological and biomedical field.
8
Conclusion

Chemical modification of CNT opens the new horizons in the study of
the biological properties of CNT

CNTs are being developed for a host of biomedical and biotechnological
applications, including drug delivery, enzyme immobilization and DNA
transfection.

Further advances in continuing investigations may depend on an
improved understanding of biological properties of CNTs – broader
exploration of other bio application opportunities beyond those that have
been identified.
9
Acknowledgment

Dr. Kevin Ausman

Chemistry Department - OSU

Friends and Family
10