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Document related concepts
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Transcript 
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Oxaloacetate
3-PG
Serine
3-PG
Serine
Nucleic Acid Biosynthesis
FGAM synthase/FGAR amidotransferase
B
H
N
O
ADP
O
P
H
NH2
H
N
OO
O-
O
NH
O
2-O
3PO
H
N
H
N
O
+H
2N
NH
NH+
H2N
O
2-O
3PO
NH
O-phosphorylated
Amide intermediate
FGAM Cyclase
B
H
N
H
H+
N
N
O
+H N
2
NH
OPO32-
OPO32+H N
2
N
+H N
2
H
N
O
B
ADP
O
P
O-
O-
B
H
N
H2N
N
+H N
2
N
N
Vertebrates
Microbial
O
N
2-O
3PO
O-
H2N
N
AIR Carboxylase
-O
N
O
B
O
H
N
-O
+H
2N
N
O
N
-O
H2 N
N
N
H
N
PRPP + 2glutamine + H2O + glycine + 5ATP + 2N10-formyl THF + CO2 + aspartate --->
2Glutamate + PPi + 5ADP + 5Pi + 2THF + fumarate + inosine
ATP is required to make purines!
Which came first? The chicken or the egg?
Did it once depend on another polyphosphate?
Inosine monophosphate + aspartate + GTP --->
adenosine monosphosphate + fumarate + GDP + Pi
Inosine monophosphate + 2H2O + NAD+ + glutamine + ATP --->
guanosine monosphosphate + glutamate + AMP + PPi
GTP is used to make ATP
And ATP is used to make GTP
Pyrimidine biosynthesis
oxaloacetate
Cytidylate synthase
O
-O
B
P
O
ADP
OPO32-
O
O-
NH2
H
N
N
O
H
O
B
NH2
N
O
ATP + AMP ---> 2 ADP
ATP + NMP ---> ADP + NDP
ATP + NDP ---> ADP + NTP
Succinyl-CoA
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