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Lecture 2 – Tubular GI
Histology of the Esophagus,
Stomach and Intestines
Dr. Pillinger
Lecture on Friday, 8/3/2012
Lecture Material Only
General Structure of the Digestive tract
1a. What is this layer
1b. What does this layer
include (three things)
2. What is this layer
3a. What is this layer
3b. What does this layer
include (two things)
4. What is this layer
Components of Wall of GI Tract
Meissner submucosal plexus
10
5
Auerbach myenteric
nerve plexus
6
1
7
2
3
9
4
4
8
LP = lamina
propria
MM =
muscularis
mucosae
MP =
muscularis
externa
SM =
submucosa: PG
=
parasympatheti
c ganglion
Components of Wall of GI Tract
1
CM = circular
layer of
smooth
muscle
3
2
Auerbach’s
myenteric
plexus
LM =
longitudinal
layer of
smooth
muscle
Histology of Esophagus
Squamous epithelium
Lamina propria with papilla
mucosa
Muscularis mucosa
Lymphoid follicle in submucosa
submucosa
Inner circular muscle
Connective tissue
Outer longitudinal muscle
muscularis
Histology
of
Esophagus
Normal esophageal mucosa
1
Epithelium of
Non-keratinizing stratified
squamous mucosa
2
lamina propria coming into epithelium
(papilla formation
Esophagus (cross sections)
1 – name boxes
Top to bottom
3?
7?
4?
5?
6?
2?
Esophagus
(Masson's trichrome)
8
7
2
6
5
1
4
3
CM = inner circular layer of
muscularis propria
E = epithelium
G = seromucous gland
LM = outer longitudinal
layer of muscularis propria
LP = lamina propria
Ly = lymphoid aggregates
MM = muscularis mucosae
MP = muscularis propria
SM = submucosa
Type of epithelium?
Squamous
Type of epithelium?
Columnar
pylorus
Normal GE
junctions
Rugae
Semi-aligned drawing & micrograph of gastric glands
Body of the stomach
C = circular layer of
muscularis externa
GP = gastric pits
L = longitudinal layer
of muscularis
externa
M = mucosa
MM = muscularis
mucosa
O = oblique layer of
muscularis externa
Base of gastric gland
E = enteroendocrine cell
Pc = chief cells
PI = parietal cells
Stomach: Pyloric area Immunostain for Gastrin
MM =
muscularis
mucosa
G = gastrin
secreting
enteroendocrin
e cells
P = gastric pits
Gastroduodenal junction (pylorus)
B = Brunner glands
CM = circular layer
of muscularis
D = duodenum
LM = longitudinal
layer of muscularis
PS = pyloric
sphincter
S = stomach
Submucosal
glands
Muscularis
mucosa
submucosa
Dilated blood
vessel
Lymphatic
vessels
Inner layer of
circular muscularis
Normal small bowel
Outer layer of
longitudinal
muscularis
Auerbach’s myenteric
plexus would be here
Monkey duodenum
B = Brunner's submucosal glands
CM = inner circular layer of
muscularis
LM = longitudinal layer of
muscularis
M = mucosa
MM = muscularis mucosa
SM = submucosa
V = villi
© Elsevier. Young et al. Wheater’s Functional Histology 5e – www.studentconsult.com
Goblet
cells
Inflammatory
Cells
Crypts
villi
Nuclei
Lamina
propria
Muscularis
mucosa
Normal small bowel: histology
Submucosa
Intestine:Crypts of Lieberkuhn
G = goblet cell
Mt = mitotic figure
P = Paneth cell
E = enteroendocrine cell
What layer of the GI tract is this?
Duodenum
What layer of the GI
tract is this?
Ileum
B = Brunner's glands
CM = inner circular layer of
muscularis
LM = longitudinal layer of
muscularis
M = mucosa
MM = muscularis mucosa
PC = plicae circularis
SM = submucosa
Sr = serosa
V = villi
C = crypts of Lieberkuhn
LP = lamina propria
What is this?
Intestinal villi & crypts
B = Brunner's glands
CM = inner circular layer of
muscularis
LM = longitudinal layer of
muscularis
M = mucosa
MM = muscularis mucosa
PC = plicae circularis
SM = submucosa
Sr = serosa
V = villi
C = crypts of Lieberkuhn
LP = lamina propria
C = capillary
L = lacteal
Ly = lymphocytes
Mu = smooth
muscle fiber
Mitosis
Intestinal villi (a) H&E (b) PAS/iron H/orange G (c) H&E
Slide 24
Folding of small intestine
Fold, plica
circulares
M = muscularis
externa
P = plica circulares
S = serosa
SM = submuscosa
V = villi
What area of the
GI tract is this?
Ileum with Peyer’s patches
Normal appendix
S = serosa
M = mesentery
F = follicle
LP = lamina
propria
Colon
submucosa
fat
CM = circular layer of muscularis
LM = longitudinal layer of muscularis
LA = lymphatic nodule
Goblet cells
Recto-anal junction
J = line of Hilton
RM = rectal
mucosa
SS = skin
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