Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
IIC Information Flow sample Step 1 Step 2 N Interesting ions? Y Priority list of interesting ions Empty priority list? N Step 3 N N QA/QC? Peptide identification Y Protein identification External Databases query Y IIC Architecture Intelligent Instrument Control • Algorithms design – Design of the MS simulator, Task 1: Hazem – Spectra Deconvolution (Data filters and noise removal) Task 2: Mohamed Eltabakh – Protein/peptide identification Task3: Mingwu – Other simple algorithms, e.g., priority list, – IIC design and architecture (API, … ) Dr. Ahmed – Integrated Access to external databases (protDB to support identification and other BioDBs to support correlation with other information, for example interactive proteins, related metabolites, etc.) • Experimental Simulation – In silico generation of spectrum, Task 1: Hazem – Algorithms implementation (simulation) Intelligent Instrument Control • Integration with the instrument – – – – Data collection (API) Control of the instrument (API) Actual implementation (algorithms) Database design: • Data representation (streams, database) • Optimized storage of massive data – Raw data – Analyzed data • Experimental settings Dr. – Selection of a biology system, e.g., yeast – Two types of experiments • Target analysis • Global analysis Intelligent Instrument Control • Prediction of upcoming peaks (need more data to build math model) • Online data mining Integrated Access to External Bio-databases • Context: Informatics tools – Glycosylated peptide identification – Non-glycosylated peptide identification • Goal: Enabling uniform access to different protein databases Integrated Access to External Bio-databases • Tasks – Database description and organization, and Schema mediation – Query Processing – Data correlation • E.g., Sequence alignment • Non-overlapping schemas • Contradictory information – Web service enabled access • Settings: Target databases selection (focus)