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Machine Learning and Data Mining Are Everywhere of Our Lives Game playing and problem solving Intelligent virtual environments for treatment and rehabilitation Machine Learning and Data Mining Industrial and engineering applications Medicine, bioinformatics and systems biology Homeland security applications …… Economics, business and forecasting applications My Research in ML and DM Putative protein function prediction Multi-Label Learning Image/video/music tagging Multi-Instance Learning Structured Sparsity Learning Disease sensitive biomarker identification Drug development Disease causative gene prediction Directed Graph Learning Transfer Learning Heterogeneous Data Integration Video completion Human emotion detection Multi-Relational Learning Social network analysis Web page ranking Detect Gene Mutations for Human Diseases • Many major human diseases, such as cancer and neurodegenerative disorders, affects millions of people worldwide. • Cause of these diseases: gene mutations (such as singlenucleotide polymorphism (SNP) or copy number variations). Mining Materials Genome Data for Performance Prediction and Design Guidance of Nanoparticle Synthesis Multi-Instance Learning • The main challenge in MIL is instance-level labeling ambiguity. I tackle this by proposing a novel Class-to-Bag (C2B) distance. ― ― ― ― Wang et al. AAAI’11 Wang et al. NIPS’11 Wang et al. ACM Multimedia’11 Wang et al. IEEE CVPR’12 Multi-Relational Learning • Most traditional clustering algorithms concentrate on dealing with homogeneous data, in which all the objects are of one single type. • Recently, rapid progress of Internet and computational technologies have brought Web data much richer in structure, involving objects of multiple types that are related to each other. ― Wang et al. ACM CIKM’11 ― Wang et al. IEEE ICDM’11