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Digestion, Absorption and Transport Digestion • Basic anatomy of the GI tract –mouth esophagus stomach small intestine large intestine rectum anus –lumen GI Tract Anatomy Digestion • Mouth –Tongue –Teeth •Mastication (chewing) The Teeth Digestion • Pharynx • Epiglottis • Esophagus –Esophageal sphincters –Bolus Digestion • Stomach –Chyme –Pyloric sphincter Stomach Muscles Digestion • Small intestine –Duodenum –Jejunum –Ileum Digestion • Gallbladder • Pancreas Digestion • Large intestine = colon –Ileocecal valve –Appendix • Rectum –Anus Peristalsis & Segmentation Muscular Action of Digestion • Segmentation Muscular Action of Digestion • Sphincter contractions –Reflux Secretions of Digestion • Catalysts –Hydrolysis –Digestive enzymes Secretions of Digestion • Saliva –Salivary glands •Water, salts, mucus, enzymes Secretions of Digestion • Stomach –Gastric juice –Gastric glands •Water, enzymes, hydrochloric acid (HCl) Secretions of Digestion • Stomach –Goblet cells •Mucus Secretions of Digestion • Pancreas –Pancreatic juice •Enzymes, bicarbonate Secretions of Digestion • Liver –Bile •Emulsifier • Gallbladder The Final Stage • Stools • Colon –Fermentation of undigested residues Digestion of a Sandwich (1) Digestion of a Sandwich (2) Absorption Absorption in the Small Intestine • Villi –Microvilli –Capillaries and lacteals –Chylomicrons • Crypts Small Intestinal Villi The Small Intestinal Villi, cont’d Circulatory Systems • Vascular system –Heart –Arteries –Capillaries –Veins –Lymph system-not part of it! Circulatory Systems • Vascular system –Portal vein-blood from GI tract toward capillaries in the liver. –Hepatic vein-liver to heart. The Liver Regulation of Digest. • Hormones –Gastrin-controls secretion of gastric acid –Secretin-facilitates secretion of pancreatic juice (bicarbonate) –Cholecystokinin = CCK (bile release from gall bladder, slows GI motility)