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Cell Biology and
Cancer
Biomedical Technology
Causes and development of cancer

Many different agents


Doesn’t happen all at once
Multi-step process
Causes and Development of Cancer

Breakdown of process that regulate the
growth of normal cells and tissues



Uncontrolled division of body cells
Cell division is normally precisely regulated
Cell cycle regulation is accomplished by genes
Causes and Development of Cancer



Cancer-causing agents damage genes
Leads to increase in the division attempts –
cell divides more than it normally would
Cancer results from genetic damage to
cells across time
Causes and Development


Research leads to understanding of normal
cells
New strategies for treatment
Cancer stages





Mutation
Hyperplasia
Dysplasia
In situ (tumor)
Invasive Cancer (malignant)
Stages of Cancer

Mutation-change in the way cells function
or develop, caused by an inherited genetic
defect or an environmental exposure. May
lead to cancer.
Stages of Cancer Cont:

Hyperplasia- Precancerous condition in
which there is an increase in the number of
normal cells lining an organ
Stages of Cancer Cont:

Dysplasia – Abnormal cells that ARE NOT
cancer (not cancer yet)
Stages of Cancer cont:

In Situ (tumor)- Cancer that has remained
within the tissue in which it originated
Stages of Cancer Cont:

Invasive Cancer (malignant) – Cancer that
has spread beyond the layer of tissue in
which it developed.
Advanced Renal Carcinoma
This is a
kidney with
cancer. The
yellowish balls
are different
tumors.

Bladder Cancer
This
is
bladder
cancer. Seen
using a
cystoscope.
 See the
cauliflower
appearance
of the tumor?
Liver Metastases
This
person had
cancer
somewhere else
in their body and it
metastasized into
their liver.
Notice all of the
yellowish tumors
within the liver.
Metastatic Lung Cancer
This
person had
lung cancer that
spread to other
organs in their
body.
Notice the balls
of tumor within the
lung?
Can you see
where the trachea
is?
Stomach Cancer
Stomach
cancer.
This tumor is
still in situ.
What does
that mean?
Colon cancer
Tumor
inside the
large intestine.
Notice the growth
on the right-hand
side of the screen.
This is seen during
a colonoscopy.
Now Draw This!