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Chapter 13 Integumentary Function Integumentary System • Functions – Protects the body from pathogen invasions – Regulates temperature – Senses environmental changes – Maintains water balance • Includes: skin, nails, hair, mucous membranes, and glands Skin • Layers – Hypodermis – inner – Dermis – middle – Epidermis – outer • Keratin – protein that strengthens • Melanin – pigment that protects Glands • Sebaceous glands – produce sebum to moisturize and protect the skin • Sweat glands – Eccrine glands – secrete through skin pores in response to the sympathetic nervous system – Apocrine glands – open into hair follicles in the axillae, scalp, face, and external genitalia Understanding Integumentary Conditions • Alterations primarily result in Impaired Skin Integrity • Alterations may also result in: – Risk for Infection Vascular Birthmarks • Consist of blood vessels that have not formed correctly • Macular stains – Also called salmon patches, angel kisses, and stork bites – Most common type – Faint red marks often occurring on the forehead, eyelids, posterior neck, nose, upper lip, or posterior head – Most fade on their own by 2 years of age, although they may last into adulthood Vascular Birthmarks • Hemangiomas – – – – – – – – Also referred to as a strawberry Bright red patch of extra blood vessels in the skin May be superficial or deep Deep hemangiomas may be bluish because they involve deeper blood vessels Grow during the first year of life and then usually recede Some may leave scars as they regress; these scars can be corrected by minor plastic surgery Usually on the head or neck, but can be anywhere Most are benign, but can cause complications if they interferes with sight, feeding, breathing, or other bodily functions Vascular Birthmarks • Port-wine stains – Discolorations that look like wine was spilled on the skin – Most often occur on the face, neck, arms, and legs – Can be any size, but they grow only as the child grows – Tend to darken and thicken over – Will not resolve spontaneously – Those occurring near the eye should be assessed for possible complications Pigmented Birthmarks • Cluster of pigment cells • Can be many different colors, from tan to brown, gray to black, or even blue • Café au lait spots – Very common – Color of coffee with milk – Can be anywhere on the body and sometimes increase in number with age – One spot alone is not usually a concern, but several spots larger than a quarter can be neurofibromatosis Pigmented Birthmarks • Mongolian spots – Flat, bluish-gray patches – Often found on the lower back or buttocks – Most common on those with darker complexions (e.g., Asian, American Indian, African, Hispanic, and Southern European descent) – Usually fade, often completely, by school age without treatment Pigmented Birthmarks • Mole – Also called congenital nevi or hairy nevi – Brown nevi – Can be tan, brown, or black; flat or raised; and may have hair growth – All should be monitored for cancerous changes Birthmarks • Diagnosis: physical examination • Treatment: – – – – – – – – Varies depending on the type Some do not require treatment Larger hemangiomas often are treated with steroids Lasers are the treatment of choice for port-wine stains Moles are surgically removed Café au lait spots can be removed with laser treatment but often return Opaque makeup Support and coping strategies Albinism • Recessive condition that results in little or no melanin production • Melanin – pigment that provides color and protection while playing a role in the development of certain optic nerves • Melanin deficits cause a lack of pigment in the skin, hair, and iris • All forms cause problems with eye development and function Albinism Types • Type 1 albinism—caused by defects that affect melanin production • Type 2 albinism—caused by a defect in the P gene; have slight coloring at birth Albinism Forms • Oculocutaneous albinism – Have white or pink hair, skin, and iris color, as well as vision problems • Ocular albinism type 1 – Affects only the eyes – Skin and eye colors are usually normal; however, an eye exam will reveal no coloring of the retina in one or both irises Albinism Forms • Hermansky-Pudlak syndrome – Can occur with a bleeding disorder as well as with lung and bowel diseases – Other complex diseases may lead to localized color loss • Chédiak-Higashi syndrome – Lack of coloring all over the skin, but not complete • Tuberous sclerosis – Small areas without skin coloring • Waardenburg’s syndrome – Often a lock of hair that grows on the forehead is affected, or no coloring in one or both irises Albinism Manifestations • Skin changes – Color ranges from white to nearly the same as relatives • Hair changes – Color can range from very white to brown – People of African or Asian descent may have hair color that is yellow, reddish, or brown • Eye changes – Color ranges from light blue to brown – Irises is semi-translucent, causing some eyes to appear red • Vision changes – Nystagmus – Strabismus – Extreme nearsightedness or farsightedness – Photophobia – Astigmatism – Functional blindness Albinism • Diagnosis: history, physical examination (including a thorough ophthalmology exam), and genetic testing Albinism • Treatment: – No cure – Using sunscreen – Wearing protective clothing – Limiting time outdoors – Wearing sunglasses – Wearing glasses – Eye muscle surgery – Coping strategies and support – Educational strategies (e.g., sitting at the front of the classroom, using large-print and highcontrast colors) Vitiligo • Rare condition characterized by small patchy areas of hypopigmentation • Occurs when the cells that produce melanin die or no longer form melanin, causing slowly enlarging white patches of irregular shapes on the skin • Affects all races but may be more noticeable in those with dark skin tones • The exact cause is unknown, but causes may include autoimmune conditions, genetic influences, sunburn, and emotional stress • Also associated with pernicious anemia, hypothroidism, and Addison’s disease Vitiligo • May affect any area, but usually develops on sun-exposed areas first • Can start at any age, but often first appears between 10 and 30 years of age • Appears in one of three patterns – Focal – depigmentation is limited to one or a few areas of the body – Segmental – loss of skin color occurs on only one side of the body – Generalized – pigment loss is widespread across many parts of the body, often symmetrically Vitiligo • Pathogenesis varies and difficult to predict – Patches may stop forming without treatment – Usually pigment loss spreads and can eventually involves most of the skin’s surface • Other manifestations: depigmentation of hair, mucous membranes, and retina • Diagnosis: history, physical examination, skin biopsy, serum autoantibody level, serum thyroid hormone level, and serum B12 level Vitiligo Treatment • No cure • The goal is to stop or slow the progression and attempt to return some pigment • Light therapy • Pharmacotherapy: – – – – – Oral synthetic melanizing agent Topical corticosteroid agents Topical immunosuppressants Topical repigmenting agents Oral or topical photochemotherapy Vitiligo Treatment • Skin graft • Autologous melancyte transplant (still experimental) • Permanent depigmentation of the remaining skin (a last resort reserved for extreme cases) • Sun safeguards • Coping strategies and support, which may include: – Makeup or skin dyes – Tattooing (most effective around the lips) Changes Associated With Aging • Decreased sensations of pain, vibration, cold, heat, pressure, and touch – Increase the risk of injury including falls, decubitus ulcers, burns, and hypothermia • Decreased elasticity, integrity, and moisture – Environmental factors, genetic makeup, and nutrition contribute to these changes – Blue-eyed, fair-skinned people show more of these changes • Appears thin, pale, and translucent – Epidermis thins even though the number of cell layers remains unchanged – Melanocyte numbers decreases but increase in size Changes Associated With Aging • Large pigmented spots (lentigos) may appear in sun-exposed areas • Changes in the connective tissue reduce the skin’s strength and elasticity • Dermis blood vessels become fragile, leading to bruising, cherry angiomas, and other similar conditions • Sebaceous glands produce less sebum – Men experience a minimal decrease, usually after the age of 80 – Women gradually produce less sebum beginning after menopause – Difficult to maintain skin moisture Changes Associated With Aging • The subcutaneous fat layer thins – Increases risk of skin injury and reduces the ability to maintain body temperature – Changes the actions of some medications • Sweat glands produce less sweat – Contributes to the difficulty in controlling body temperature • Repairs itself more slowly – Wound healing may be up to four times longer – Contributes to decubitus ulcer formation and infections – The presence of chronic diseases along with other changes with aging (e.g., impaired immunity and circulatory changes) further delays healing Changes Associated With Aging • Skin tags – Benign, soft brown or flesh-colored masses – Usually occurs on the neck – Most are painless, but can become inflamed in the presence of constant friction – More common in persons who are obese or have diabetes mellitus – Can be removed with surgery, cryotherapy, and cautery Contact Dermatitis • Acute inflammatory reaction triggered by direct exposure to an irritant or allergen-producing substance • Not contagious or life threatening • Irritant contact dermatitis – Causes: chemicals, acids, and soaps – Does not involve the immune system, just the inflammatory response – Produces a reaction similar to a burn – Manifestations: erythema, edema, pain, pruritus, and vesicles • Allergic contact dermatitis – Causes: metals, chemicals, cosmetics, and plants – Sensitization occurs on the first exposure, and subsequent exposures produce a type IV cell-mediated hypersensitivity – Manifestations appearing 24–48 hours after exposure – Manifestations: pruritus, erythema, edema, and small vesicles Contact Dermatitis • Varies in severity depending on the substance, area affected, exposure extent, and individual sensitivity • Usually resolves in 2-4 weeks • Diagnosis: history, physical examination, and allergy testing • Treatment: identify and remove the causative agent, wet compresses, anti-inflammatory creams (e.g., corticosteroid agents), and systemic anti-inflammatory agents Atopic Eczema • • • • Chronic inflammatory condition triggered by an allergen Has an inherited tendency May be accompanied by asthma and allergic rhinitis Most common in infants and usually resolves by early adulthood • Characterized by remissions and exacerbations • The exact cause is unknown, but may result from an immune system malfunction • Complications: secondary bacterial skin infections, neurodermatitis (permanent scarring and discoloration from chronic scratching), and eye problems (e.g., conjunctivitis) Atopic Eczema • May affect any area, but it typically appears on the arms and behind the knees • Manifestations – – – – – Red to brownish-gray colored skin patches Pruritus, which may be severe, especially at night Vesicles Thickened (lichenified), cracked, or scaly skin Irritated, sensitive skin from scratching • Diagnosis: history, physical examination, allergy testing, and skin biopsy (to rule out other causes) Atopic Eczema Treatment • Avoiding factors that can worsen: – – – – – – – – – – – Long, hot baths or showers Dry skin Stress Sweating Rapid changes in temperature Low humidity Solvents, cleaners, soaps, or detergents Wool or synthetic fabrics or clothing Dust or sand Cigarette smoke Certain foods (e.g., eggs, milk, fish, soy, and wheat) • Avoiding scratching • Moisturizing the skin by applying ointments 2–3 times daily Atopic Eczema Treatment • Using a humidifier • Strategies when washing or bathing: – Keep water contact brief and use little soap – Do not excessively scrub or dry the skin – Apply lubricating creams, lotions, or ointment on the skin after while it is damp to trap moisture in the skin • Pharmacology – – – – – Antihistamine agents (may be topical or oral) Corticosteroid agents (may be topical or oral) Immunomodulators (may be topical or oral) Antibiotics (may be topical or oral if infection is present) Allergen desensitizing injections • Receiving phototherapy Urticaria • Raised erythematous skin lesions (welts) • Result of a type I hypersensitivity reaction often triggered by food (e.g., shellfish and nuts) and medicine (e.g., antibiotics) • May also be a result of emotional stress, excessive perspiration, diseases (e.g., autoimmune conditions and leukemia), and infections (e.g., mononucleosis) • Caused by histamine release initiated by these substances or conditions Urticaria • Usually short-lived and harmless • Can impair breathing if around the face and progress to anaphylaxis and shock • Diffuse welts may grow large, spread, and fuse together • Manifestations: welts that blanch and pruritus • Diagnosis: history, physical examination, and allergy testing • Treatment: avoid hot baths or showers, avoid further irritation, antihistamines, epinephrine, corticosteriods, and maintain respiratory status Psoriasis • Common chronic inflammatory condition that affects skin cell life cycle • Cellular proliferation is significantly increased, causing cells to build up too rapidly on the skin’s surface • Normally takes weeks, but occurs over 3–4 days with psoriasis • Buildup leads to thickening of the dermis and epidermis because dead cells cannot shed fast enough • The exact cause is unknown, but it is thought to be a result of an autoimmune process in which T lymphocytes mistake normal skin cells as foreign Psoriasis • Has a family tendency • Onset is most frequently between 15 and 35 years of ages, and may be sudden or gradual • Usually experience remissions and exacerbations • Factors that trigger an exacerbation or worsens: bacteria or viral infections in any location, dry air or dry skin, skin injuries, certain medicines (e.g., antimalaria agents, beta blockers, and lithium), stress, too little or too much sunlight, and excessive alcohol consumption Psoriasis • Severity varies • May also have arthritis • May be severe in persons who have a weakened immune system • Begin as a small, red papule • Papules most often occur on the elbows, knees, and trunk, but they can appear anywhere Psoriasis • Papules develop into one of the following lesions: – Erythrodermic—intense erythema and that covers a large area – Guttate—small, pink-red spots – Inverse—erythema and irritation that occurs in the armpits, groin, and in skin folds – Plaque—thick, red patches covered by flaky, silver-white scales (the most common type) – Pustular—white blisters surrounded by red, irritated skin • Other manifestations: genital lesions in males, joint pain or aching, nail changes (e.g., thickening, yellow-brown spots, pits on the nail surface, and separation of the nail from the base), and dandruff Psoriasis • Diagnosis: history, physical examination, skin biopsy, and other tests to rule out other conditions that mimic psoriasis (e.g., seborrheic dermatitis and tinea corporis) Psoriasis Treatment • No cure • Requires a multiprong approach • Topical treatments: corticosteroid agents, vitamin D analogues, anthralin (Dritho-Scalp), retinoids, calcineurin inhibitors, salicylic acid, coal tar, and moisturizers • Phototherapy: sunlight, broadband ultraviolet B (UVB) phototherapy, narrowband UVB phototherapy, photochemotherapy (psoralen plus ultraviolet A), and excimer laser • Systemic pharmacotherapy: retinoids, methotrexate, cyclosporine, hydroxyurea, and immunomodulator drugs • Stress management • Avoiding triggers Bacterial Infections • Can be caused by any of the normal flora bacteria • Varies from mild to life threatening • Staphylococcus and Streptococcus genera are common culprits • Folliculitis – Involving the hair follicles – Characterized by tender, swollen areas that form around hair follicles, often on the neck, breasts, buttocks, and face Bacterial Infections • Furuncles – Begins in the hair follicles and then spreads into the surrounding dermis – Most commonly occur on the face, neck, axillae, groin, buttocks, and back – Starts as a firm, red, painful nodule that develops into a large, painful mass, which frequently drains large amounts of purulent exudate – Carbuncles refer to clusters of furuncles Bacterial Infections • Impetigo – Common and highly contagious – Can occur without an apparent skin break, but typically arises from a break in the skin – Lesions usually begin as small vesicles that enlarge and rupture, forming the characteristic honey-colored crust – Can spread throughout the body through selftransfer of the exudate – Typically caused by a staphylococcal infection, which produce a toxin that attacks collagen and promotes spread – Other manifestations: pruritus and lymphadenopathy Bacterial Infections • Cellulitis – Occurs deep in the dermis and subcutaneous tissue – Usually results from a direct invasion through a break in the skin, especially those breaks where contamination is likely, or spreads from an existing skin infection – Appears as a swollen, warm, tender area of erythema – Systemic manifestations: indicators of infection(e.g., fever, leukocytosis, malaise, and arthralgia) – Complications: necrotizing fasciitis, septicemia, and septic shock Bacterial Infections • Necrotizing fasciitis – Rare, serious infection, but rates are rising – Can aggressively destroy skin, fat, muscle, and other tissue – Typically results from a highly virulent strain of gram-positive, group A, beta-hemolytic Streptococcus that invade through a minor cut or scrape – The bacterium release harmful toxins that directly destroy the tissue, disrupt blood flow, and break down the tissue – The first sign may be a small, reddish, painful area that quickly changes to a painful bronze- or purple-colored patch – The center of the lesion may become black and necrotic – Exudate is often present – The wound may grow in less than an hour – Systemic manifestations: fever, tachycardia, hypotension, and confusion – Complications: gangrene and shock Bacterial Infections • Diagnosis: history, physical examination, and cultures • Treatment: organism specific antibiotics, wound care, adequate hydration, surgical debridement, drainage, antipyretic agents, and analgesic agents Viral Infections • Herpes simplex type 1 – Typically affecting the lips, mouth, and face – Usually begins in childhood – Can involve the eyes, leading to conjunctivitis – Can result in meningoencephalitis – Transmitted by contact with infected saliva – The primary infection may be asymptomatic – After the primary infection, the virus remains dormant in the sensory nerve ganglion to the trigeminal nerve until it is reactivated – Reactivation may be a result of an infection, stress, or sun exposure – When reactivated, causes painful blisters or ulcerations that are preceded by a burning or tingling sensation – The lesions resolve spontaneously within 3 weeks, but healing can be accelerated with oral or topical antiviral agents Viral Infections • Herpes zoster – Caused by the varicella-zoster virus – Appears in adulthood years after a primary infection of varicella in childhood – The virus lies dormant on a cranial nerve or a spinal nerve dermatome until it is activated years later – The virus affects this nerve only, giving the condition its typical unilateral manifestations. – Manifestations: pain, paresthesia, a red or silvery vesicular rash that develops in a line over the area innervated by the affected nerve (one side of the head or torso), extremely sensitive skin, and pruritis – The rash may persist for weeks to months – Complications: neuralgia and blindness – Treatment: antivirals, antidepressants, and anticonvulsants Viral Infections • Verrucae – Warts caused by a number of the human papillomaviruses – Can develop at any age and often resolve spontaneously – Transmitted through direct skin contact between people or within the same person – The human papillomavirus replicates in the skin cells, causing irregular thickening – Varying color, shape, and texture – Treatment: laser treatments, cryotherapy with liquid nitrogen, electroclautry, and topical medications (e.g., keralytic, cytotoxic, and antiviral agents) – May return after treatment Parasitic Infections • Tinea – Causes several types of superficial fungal infections – These fungi typically grow in warm, moist places (e.g., showers) – Typically manifests as a circular, erythematous rash accompanied by pruritus and burning – Tinea capitis – involving the scalp • Common in school-aged children • Hair loss at the site is common Parasitic Infections • Tinea – Tinea corporis – involving the body – Tinea pedis – involving the feet, especially the toes – Tinea unguium – involving the nails, typically the toenails • Begins at the tip of one or two nails and then usually spreads to other nails • Turns nails white and then brown, causing them to thicken and crack – Treatment: topical and systemic antifungal agents Parasitic Infections • Scabies – Result of a mite infestation – Male mites fertilize the females and then die – Female mites burrow into the epidermis, laying eggs over a period of several weeks through tracks – After laying the eggs, the female mites die – Larvae hatch from the eggs and then migrate to the skin’s surface – Larvae burrow in search of nutrients and mature to repeat the cycle – Burrowing appears as small, light brown streaks on the skin – Burrowing and fecal matter left by the mites triggers the inflammatory process, leading to erythema and pruritus – Mites can only survive for short periods without a host, so transmission usually results from close contact – Treatment: topical treatments Parasitic Infections • Pediculosis – Lice infestation – small, brown, insects that feed off human blood and cannot survive long without host – Pediculus humanus corpus – body louse – Pediculus pubic – pubic louse – Pedicuus humanus capitis – head louse – Females lay nits on the hair shaft close to the scalp – Nits appear as small white, iridescent shells on the hair – After hatching, the lice bite and suck the blood – Bite site develops a highly pruritic macule or papule – Easy transmitted through close contact – Treatment: several topical treatments Parasitic Infections • Diagnosis: microscopic examination of skin scrapings processed with potassium hydroxide • Many feed off the dead skin cells of the host and may use the host as a breeding ground Burns • Injury that can result from a thermal or a nonthermal source • Sources: dry heat (e.g., fire), wet heat (e.g., steam or hot liquids), radiation, friction, heated objects, natural or artificial UV light, electricity, and chemicals (e.g., acids, alkaline, and paint thinner) • Triggers inflammatory reaction and results in tissue destruction • First-degree burns – affect only the epidermis and cause pain, erythema, and edema • Second-degree burns – affect the epidermis and dermis and cause pain, erythema, edema, and blistering • Third-degree burns – extend into deeper tissues and cause white or blackened, charred skin that may be numb Burns • Complication: local infection (particularly Staphylococcus infection), sepsis, hypovolemia, shock, hypothermia, respiratory problems, scarring, and contractures • Diagnosis: history, physical examination (including determining the total body surface area affected), chest X-ray, endoscopy, complete blood count, and blood chemistry Burn Treatment • Strategies for minor burns – Remove the source of the burn – If the skin is unbroken, run cool water over the area of the burn or soak it in a cool water bath (not icy) – Keep the area submerged for at least 5 minutes – After flushing or soaking, cover the burn with a dry, sterile bandage or clean dressing – Protect the burn from pressure and friction – Analgesics – Nonsteroidal anti-inflammatory drugs – Apply moisturizing lotion once the skin has cooled – If a second-degree burn covers an area more than 2–3 inches in diameter, or if it is located on the hands, feet, face, groin, buttocks, or a major joint, treat the burn as a major burn Burn Treatment • Strategies for major burns – Remove the source of the burn – If someone is on fire, have the person to stop, drop, and roll. Wrap the person in thick material to smother the flames e.g., (a wool or cotton coat, rug, or blanket). Douse the person with water. – Do not remove burned clothing that is stuck to the skin. The clothing may be soaked and then removed, and surgical removal may be necessary in severe cases. – Ensure the person is breathing. Initiate rescue breathing and cardiopulmonary resuscitation if necessary. Continue to monitor respiratory status because it can become impaired as edema worsens. – Maintain respiratory status (e.g., endotracheal intubation with mechanical ventilation, oxygen therapy) – Cover the burn area with a dry sterile bandage or clean cloth. Do not apply any ointments. Avoid rupturing blisters. Burn Treatment • Strategies for major burns – If fingers or toes are involved, separate them with dry, sterile, nonadhesive dressings. – Elevate the affected body part – Protect the burn area from pressure and friction – Prevent shock by place the individual in Trendelenburg position and cover the person with a coat or blanket. However, do not place the person in this position if a head, neck, back, or leg injury is suspected or if it makes the person uncomfortable. – Monitor vital signs for signs of shock – Administer intravenous fluids (usually colloids or crystalloids) using specific formulas Burn Treatment • Strategies for major burns – Administer oral, intravenous, or topical analgesics, sedatives, or antibiotics – Implement reverse isolation – Meticulous wound care – Protective dressings – Skin grafting – Surgery to close the wound, remove the dead tissue, or treat related complications (e.g., scarring and contractures) – Physical therapy – Increase dietary intake of protein and carbohydrates Acne Vulgaris • Commonly affects adolescents, but it can occur at any age • Pores become clogged with oil, debris, or bacteria • Can become inflamed and develop a pustule, nodule, or cyst • May present as whitehead or blackhead • Rupturing can spread the material inside to the surrounding area and cause an inflammatory reaction • Commonly appears on the face and shoulders, but it may also occur on the trunk, arms, legs, and buttocks Acne Vulgaris • Complications: scarring • Risk factors: family history, hormonal changes, using oily cosmetic and hair products, certain medications (e.g., corticosteroids, testosterone, estrogen, and phenytoin), and high levels of humidity and sweating • Diagnosis: history and physical examination Acne Vulgaris Treatment • Clean with a mild, nondrying soap once or twice a day, including after exercising; however, avoid excessive or repeated skin washing • Shampoo hair daily, especially if it is oily • Comb or pull hair back to keep the hair away from the face, but avoid tight headbands Acne Vulgaris Treatment • Avoid squeezing, scratching, picking, or rubbing areas • Avoid touching affected areas • Avoid oily cosmetics or creams; use waterbased or noncomedogenic formulas • Over-the-counter or prescription acne products containing benzoyl peroxide, sulfur, resorcinol, or salicylic acid • Oral or topical antibiotics (e.g., erythromycin) Acne Vulgaris Treatment • • • • • • • • • • • Oral or topical antibiotics (e.g., erythromycin) Retinoic acid cream or gel (e.g., Retin-A) Oral isotretinoin (Accutane) Oral contraceptives Alternative therapies including tea tree oil, zinc, guggul, and brewer’s yeast Photodynamic therapy Chemical skin peels Microdermabrasion Dermabrasion Soft-tissue fillers (e.g., collagen, and fat) Limit sun exposure Rosacea • Chronic, progressive inflammatory condition that typically affects the face • Prevalent in persons who are fair skinned, bruise easily, and women • May present as erythema, telangiectasia, swelling, or acnelike eruptions • Other manifestations: rhinophyma, a burning or stinging sensation, and red, watery eyes • Usually experience remissions and exacerbations • Exacerbation triggers: sun exposure, sweating, stress, spicy food, alcohol, hot beverages, wind, hot baths, and cold weather • Diagnosis: history and physical examination Rosacea Treatment • • • • • • • • • • • • • No cure Avoid triggers Avoid excessive scrubbing when cleaning Avoid sun exposure and use sunscreen Avoid prolonged physical exertion in hot weather Stress management Limit spicy foods, alcohol, and hot beverages Topical or oral antibiotics Retinoic acid cream or gel (e.g., Retin-A) Oral isotretinoin (Accutane) Laser surgery Surgical reduction of enlarged nose tissue Green- or yellow-tinted prefoundation creams and powders Skin Cancer • Abnormal growth of skin cells • Most frequently occurring cancer in US • Most prevalent in males, Caucasians, those with fair complexion, and those with a family history • UV exposure, natural or artificial, is the most significant risk factor • Most skin cancers occur on areas that have the most sun exposure Skin Cancer • Basal cell carcinoma – Most common – Develops from abnormal growth of the cells in the lowest layer of the epidermis – Rarely metasticize • Squamous cell carcinoma – Involves changes in the squamous cells, found in the middle layer of the epidermis • Melanoma – Develops in the melanocytes – Least common type but the most serious – Often metastasize to other areas Skin Cancer • Vary widely in appearance • Can be small, shiny, waxy, scaly, rough, firm, red, crusty, bleeding, and so on • Any suspicious skin lesion should be examined • Suspicious features: – – – – – – Asymmetry Borders irregularity Color variations Diameter larger than 6 mm in size Any skin growth that bleeds or will not heal Any skin growth that changes in appearance over time Skin Cancer • • • • Early detection is crucial to positive outcomes Diagnosis: history, physical examination, and biopsy Prevention: limiting or avoiding exposure to UV light Treatment: cryosurgery, excisional surgery, laser therapy, Mohs’ surgery (the skin growth is removed layer by layer, examining each layer under the microscope, until no abnormal cells remain), curettage and electrodessication (involves scraping layers of cancer cells away using a circular blade [currette] and then using an electric needle to destroy any remaining cancer cells), radiation therapy, and chemotherapy