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Readings for Epidural Education Course for Nurses ACUTE PAIN MANAGEMENT SERVICE CHRISTCHURCH HOSPITAL BOOKLET TO BE READ IN CONJUNCTION WITH Canterbury DHB Policy and Procedure Manual Epidural Standard and Procedures – Post Operative Patients Volume 12, Fluid and Medication Manual The Department of Nursing Christchurch Hospital Developed by: Richard Craig Clinical Nurse Specialist, APMS Updated March 2012-02-29 CONTENTS INTRODUCTION .............................................................................................................................. 3 LEARNING OBJECTIVES................................................................................................................ 4 ASSESSMENT CRITERIA: SURGICAL CONTEXT ...................................................................... 4 ADVERSE EFFECTS OF ACUTE PAIN .......................................................................................... 5 Adverse Physiological Effects of Acute Pain ........................................................................... 5 ASSESSING PAIN IN ADULTS & CHILDREN .............................................................................. 6 Figure One: Verbal Analogue Scale ........................................................................................ 6 Figure Two: Visual Scale for Children.................................................................................... 7 INTRODUCTION TO EPIDURAL ANALGESIA INFUSIONS ...................................................... 8 Table One: Uses of Epidural Analgesia Anaesthesia .............................................................. 8 BENEFITS OF EPIDURAL INFUSIONS ......................................................................................... 9 INDICATIONS FOR USE OF EPIDURAL INFUSION ................................................................... 9 CONTRAINDICATIONS FOR USE OF EPIDURAL INFUSION ................................................... 9 EPIDURAL INSERTION ANALGESIA (EIA) TECHNIQUE ....................................................... 10 TO CONTACT THE ACUTE PAIN MANAGEMENT SERVICE ................................................. 10 SPINAL ANATOMY ....................................................................................................................... 11 Figure Three: Vertebral column ............................................................................................. 12 Figure Four: Spinal anatomy ................................................................................................ 12 DEPTH TO SPACE MEASUREMENT OF EPIDURAL CATHETER .......................................... 13 Figure Five: Epidural Catheter ............................................................................................... 14 NURSING MANAGEMENT OF CHILDREN RECEIVING EPIDURAL INFUSION ................. 15 COMMON DRUGS USED IN EPIDURAL INFUSIONS .............................................................. 16 Local Anaesthetic (LA) Mechanism of Action ............................................................................................................. 16 Table Two: Nerve Fibre Class, Size and Function ................................................................ 17 Bupivacaine ............................................................................................................................ 17 Figure Six: Bromage Scale ..................................................................................................... 19 Ropivacaine ............................................................................................................................ 20 Opioid Agents Fentanyl .................................................................................................................................. 20 Alpha Agonist Adrenaline .............................................................................................................................. 20 Clonidine ................................................................................................................................ 21 Opiate Antagonists Narcan (naloxone) .................................................................................................................. 21 Vasopressers Ephedrine ................................................................................................................................ 21 Table Three: Epidural Drugs Adults ...................................................................................... 23 Table Four: Epidural Drugs Children.................................................................................... 24 RESCUE REGIME RECOMMENDED BY APMS ........................................................................ 25 PROCEDURES FOR NURSING MANAGEMENT ....................................................................... 26 PROMOTING MOBILISATION ..................................................................................................... 27 PATIENT CONTROLLED EPIDURAL ANALGESIA : AN INTRODUCTION TO TECHNIQUES AND GUIDELINES ......................................................................................... 29 ASSESSING DERMATOME SENSORY BLOCK LEVELS ......................................................... 30 Figure Seven: Dermatome Chart ............................................................................................ 32 “BRIDGING” FROM THE EPIDURAL .......................................................................................... 32 Figure Eight: Flow on Analgesia Post EIA ............................................................................ 33 Epidural Complications……………………………………………………………………..34 S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 1 INTRODUCTION Welcome to the Epidural Education Course. Please read the information provided carefully taking special note of the learning objectives. You will not be tested on anything that is not included in these objectives. I have endeavoured to ensure that the material enclosed is as up to date and relevant as possible. However, as I‟m sure you‟ll appreciate; these modalities are subject to change and consequently will need modification from time to time as appropriate. This booklet is to be read in conjunction with: Canterbury DHB Policy and Procedure Manual Post operative patients Volume 12 Fluid and Medication Manual Department of Nursing Christchurch Hospital This is available via the intranet, if you do not have access to the intranet manual copies are available in the Medical Library. Finally, please feel free to direct to me any comments or suggestions you may have regarding these readings. Richard Craig Clinical Nurse Specialist Acute Pain Management Service March 2012 S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 2 LEARNING OBJECTIVES The Registered Nurse (RN) will be able to: a) Describe the basic spinal anatomy relating to epidural infusion analgesia. b) State his/her role in the management of a patient with an epidural analgesia infusion conduct a comprehensive assessment of patient‟s pain assessing dermatome sensory block levels patient assessment and documentation mobilisation potential complications and the appropriate nursing intervention of these when and how to contact the APMS [Canterbury DHB, Christchurch Hospital Policy] c) Paediatrics : state five differences in the care of children with epidural infusions d) Outline the care related to an epidural catheter including assessment of the dressing/site and documentation potential complications and the appropriate nursing intervention outline the procedure for removal of the epidural catheter. e) Review drugs commonly used in epidural analgesia and therapeutic action associated pharmacokinetics state three drugs commonly used in epidural analgesia and their therapeutic action state two useful adjuvants, and their therapeutic action state two drugs used as reversal agents in epidural infusion, and their expected action, precautions. f) Demonstrate operational competence with the epidural infusion pump. g) Provide comprehensive patient education (refer to Appendix C) care of adults care of children ASSESSMENT CRITERIA: SURGICAL CONTEXT For a RN to be successful the RN must: Read the Canterbury DHB, Christchurch Hospital Policy document Volume 12, Fluid and Medication Manual Epidural Standard – Post Operative Patients. This is available via the internet – if you do not have access to the internet manual copies are available in the Medical Library. Attend the epidural study day run by the Acute Pain Service at the PDU S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 3 1. ADVERSE EFFECTS OF ACUTE PAIN 1.1 Adverse Physiological Effects of Acute Pain Respiratory - pain leads to muscle splinting with decreased total volume (TV), vital capacity (VC), Functional Residual Capacity (FRC) and alveolar ventilation. Resulting atelectasis causes venous admixture, hypoxia and hypercapnia. Inability to cough leads to retention of secretions and increased disposition to lobular collapse with resultant infection. Cardiovascular – pain causes sympathetic overactivity resulting in tachycardia, hypertension, increased peripheral vascular resistance, cardiac load CO and oxygen consumption. Myocardial ischaemia and infarction may result in a susceptible patient. Regional blood flow is also altered and cerebral blood flow may be compromised. Skeletal muscle spasm – reflex activity leads to muscle spasm which will increase pain thereby setting up a vicious cycle. Immobility will potentiate the incidence of DVT and pulmonary embolus. Venous aggregation and increased platelet aggregation adds to this problem. Gastrointestinal and genitourinary – increased sympathetic activity leads to increased secretions and sphincter tone. This can result in decreased intestinal motility and gastric dilation. Hormonal – pain is one of the factors causing hormonal response to injury. Increased ADH and aldosterone lead to sodium and water retention. Increased cortisol and Adrenaline leads to hypoglycaemia. There are many other hormonal disturbances. 1.2 Adverse Psychological Effects of Acute Pain Unrelieved pain results in anxiety and sleeplessness. This results in another vicious cycle with anxiety resulting in increased pain. The effects of decreased anxiety have been demonstrated in many studies. Patients who have good preoperative explanations have been found to require fewer opiates in the postoperative period. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 4 2. ASSESSING PAIN IN ADULTS AND CHILDREN The regular assessment of pain levels is fundamental to pain management. The tool for adult pain level assessment adopted by the APMS is the verbal analogue scale. A visual scale can be used for children. Verbal Analogue Scale The patient rates his/her pain according to the scale using numbers related to descriptive words denoting varying intensities of pain. The patient chooses the number that most nearly describes the pain they are experiencing. It is important that the patient scores his/her pain both at rest and on activity. The goal is to control the pain so that the patient can perform activities, eg physiotherapy, coughing, comfortably within pain boundaries acceptable to them. 5 Excruciating Pain 4 Severe Pain 3 Painful 2 Moderate Discomfort 1 Mild Discomfort 0 No pain Figure One: Verbal Analogue Scale S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 5 Figure Two: Visual Scale for Children Present knowledge tells us of the multiplicity of mechanisms that need to be blocked to effect good analgesia. In some instances certain mechanisms can be pre-emptively blocked before pain is initiated. However, in the majority of cases there is a need to treat pain as it arises using a variety of pharmacologic and non pharmacologic, regional and non regional means in an attempt to shut each pain pathway/mechanism „door‟ and so keep the pain from getting through. Different surgical procedures require different approaches to pain management. Most can be managed using relatively simple measures. Others require more advanced techniques of analgesia. The APMS objective is to be comprehensive in applying the variety of approaches in a way which is appropriate for each and every situation. These situations refer broadly to three aspects: 1. Type and site of surgery. 2. Severity of pain. 3. Degree of rehabilitation required. When considering the more simple, non advanced techniques we traditionally use a variety of pharmacologic agents usually considered under the categories of mild analgesia, non steroidal anti-inflammatory drugs (NSAIDS), opioid and non opioid analgesics and adjuvant agents. These will often be used in combination to achieve multimodal/mechanism analgesia. For instance, many patients will receive regular Paracetamol as a background analgesic while receiving, and after completion of, opioids and advanced analgesia techniques. NSAIDS may also be used in this way. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 6 3. INTRODUCTION TO EPIDURAL ANALGESIA Epidural Infusions are used most commonly for postoperative and obstetric analgesia. Less common applications are for trauma, pre-amputation and cancer pain as well as selected chronic pain states. Agents are i) Combination (such as low concentration local anaesthetic (LA), and opioid The preferred option is the combination infusion technique. It has been found that by using a combination of agents their concentration and side effects can be minimised while still producing excellent analgesia. Integral to this success is the placement of the catheter in the epidural space at a level as close to the mid dermatome for the surgical incision as possible. Epidural Infusion Analgesia (EIA) for postoperative analgesia, is administered by trained staff. The AIM is to provide effective analgesia using ward-based epidural infusion in selected patients. Table One: Uses of Epidural Analgesia Acute postoperative pain Intrathoracic surgery Abdominal surgery Lower limb orthopaedic surgery Vascular surgery Urological procedures Chronic pain Terminal illness Obstetrics Local anaesthetic freezes sensory and motor nerves of the uterus and vagina During operative procedures Appropriate for individuals undergoing surgery who would not be suitable for a general anaesthetic, ie those with major cardiovascular, respiratory and metabolic problems. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 7 4. BENEFITS OF EPIDURAL ANALGESIA INFUSIONS Epidural analgesia is an effective method of pain relief in a variety of situations. Benefits include: 5. INDICATIONS FOR USE OF EPIDURAL INFUSIONS 6. Effective analgesia Avoids the need for intramuscular (IM) injections Decreased nausea and vomiting More effective respiratory function No significant depression of conscious level Better compliance with dressing changes, physiotherapy and orthopaedic passive movement devices. More rapid post operative mobilisation. Lower deep vein thrombosis (DVT) rate. Improved wound perfusion Faster return in bowel function Less nursing time checking controlled drugs (efficient use of nursing resource) Decreased length of stay, earlier discharge from hospital Earlier weaning time from mechanical ventilation. For major abdominal/thoracic surgery Some pelvic/lower limb orthopaedic procedures Surgical inpatients with severe respiratory disease. Where Patient Controlled Analgesia (PCA) may be inappropriate, or as an adjuvant to PCA. CONTRAINDICATIONS FOR USE OF EPIDURAL INFUSIONS Hypovolaemia Infection Coagulopathy Raised intracranial pressure Patient refusal S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 8 7. EPIDURAL INSERTION ANALGESIA (EIA) TECHNIQUE The epidural catheter is inserted pre-operatively by the Anaesthetist using standard techniques for both the insertion and fixation of the catheter. The special Epidural Infusion Analgesia Treatment Sheet QMR0221 (Adult) or QMR0166 (Child) will be filled out and delivered to Recovery for preparation of the pump and the infusion solution. Commencement of Epidural Infusion1 Before discharge from Recovery the epidural infusion and other methods of pain relief will be adjusted to achieve maximum analgesia and effectiveness of block. The analgesia infusion solution will be prescribed and made up from premixed bags. It is delivered using the epidural specific volumetric Gemstar Pump to the epidural catheter. These pumps have the facility to deliver a bolus of drug. The system is closed apart from bag changes or technical problems (rare). The rate of infusion remains as prescribed by the Anaesthetist or APMS. Changes within the rate set will occur if required, after checking the patient‟s vital signs and dermatome level. The APMS reviews its patients at least once a day and monitors the ongoing infusion. All EIA patients will be on regular Paracetamol for basal/background analgesia during and following EIA (unless contraindicated). NB: It is particularly important that the patient receives no additional doses of opioid drugs for the duration of the infusion. Such doses/drugs should not be prescribed except after consultation with a member of the APMS. TO CONTACT THE APMS AT CHRISTCHURCH HOSPITAL/CWH – GYNAECOLOGY WARD In hours: APMS Nurse CWH(Gynaecology) Beep 8170 APMS Nurse(ChCh Hospital)Beep 8114 Duty Anaesthetist Beep 8120 After hours: On call Anaesthetic Registrar Beep 8212 or on call Anaesthetist via telephone office APMS Nurse hours: Monday – Friday Saturday Sunday 1 0800-1630 hours 0800-1400 hours 0800-1200 hours Rarely Epidurals may be commenced in Intensive Care Unit, or in Ward (chest trauma). S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 9 8. SPINAL ANATOMY The human spinal column consists of 33 individual vertebrae referred to by their location: (1) 7 Cervical (2) 12 Thoracic (3) 5 Lumbar (4) 5 caudal or sacral (fused into one bone, the sacrum) (5) 4 coccygeal (fused into one bone, the coccyx). Vertebrae consist of an anterior body, the laminae that protect the lateral spinal cord and spinous processes that project outwardly and posteriorly from the laminae. The vertebrae become larger as they descend in the vertebral column. The bones of the laminae are bound together by a number of ligaments (eg the dense ligamentum flavum). The spinal cord is located within and protected by the bony vertebral column and connective tissue (meninges). It is a continuous structure extending from the foramen magnum to approximately the first or second lumbar (L1-L2) vertebral interspace. The subarachnoid space (also called the intrathecal space in the caudal part of the spine) surrounds the spinal cord, separated by the pia mater. The subarachnoid space is filled with clear, colourless cerebrospinal fluid (CSF) that continually circulates and bathes the spinal cord. The dura is composed of the arachnoid and dura mater membranes and separates the epidural space from the subarachnoid space. The epidural space is a potential space filled with vasculative, fat and a network of nerve extensions. No fluid is in the epidural space; a true space is created when volume or air is injected into it. The fact that the epidural space is a potential space has implications for nurses. Although injecting large amounts of air is not recommended, small amounts such as tiny bubbles within the infusion tubing when therapy is initiated, are not considered dangerous. In addition, because the epidural catheter is in a space and not a blood vessel, a continuous epidural infusion may be stopped for hours and restarted without concern that the catheter has become occluded. However crystallisation of the saline within the epidural catheter can occur when catheters are unused for prolonged periods. In these cases weekly or bi-weekly irrigation is recommended. At each vertebral body level, nerve roots exit from the spinal cord bilaterally. Specific skin surface areas are innervated by a single spinal nerve or group of spinal nerves. These skin areas are called dermatomes. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 10 Fig 3. Vertebral column. The human spinal column consists of 33 individual vertebrae referred to by their locations: (1) 7 cervical, (2) 12 thoracic, (3) 5 lumbar, (4) 5 caudal or sacral (fused into one bone, the sacrum) and (5) 4 coccygeal (fused into one bone, the coccyx). At each vertebral body level, nerve roots exit from the spinal cord bilaterally. Specific skin surface areas are innervated by a single spinal nerve or group of spinal nerves. Fig 4. Spinal anatomy The spinal cord is a continuous structure extending from the foramen magnum to approximately the first or second lumbar (L1-L2) vertebral interspace. The subarachnoid space (also called the intrathecal space in the caudal part of the spine) surrounds the spinal cord, separated by the pia mater. The subarachnoid space is filled with cerebrospinal fluid (CSF) that continually circulates and bathes the spinal cord. The dura is composed of the arachnoid and dura mater membranes and separates the epidural space from the subarachnoid space. The epidural space is a potential filled with vasculature, fat and a network of nerve extensions. From Salerno E, Willens J. Pain management handbook, p 441, St Louis, 1996, Mosby From Thibodeau GA Patton KT: Anatomy & Physiology, p 463 ed 3, St Louis, 1996, Mosby S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 11 9. DEPTH TO SPACE MEASUREMENT OF EPIDURAL CATHETER When the epidural is first inserted by the Anaesthetist both the depth to space measurement and the catheter mark at skin are noted and recorded under insertion details at the top of the first page of the adult epidural infusion analgesia treatment sheet (QMR0221), or the inside page of the Paediatric Epidural Infusion Sheet (QMR0166). Depth to space is the distance from the skin to the epidural space. The epidural catheter has a series of markings upon it as illustrated in Figure Four. The “catheter mark at skin” is exactly that, ie whatever mark is nearest to the skin entry point. The amount of catheter within the epidural space is calculated by subtracting the depth to space from the catheter mark at skin. If the epidural catheter inadvertently moves out of position then this can be deduced by the fact that the catheter mark at skin will be different from the one recorded initially. Also for the occasions when the APMS “pull back” or alter the length of the catheter within the epidural space, it is important to calculate the depth to space. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 12 Key: 4 marks together = 20 cm 3 marks together = 15 cm 2 marks together = 10 cm Catheter tip is coloured and blunted Figure Five: Epidural Catheter S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 13 10. NURSING MANAGEMENT OF CHILDREN RECEIVING EPIDURAL INFUSION Notes prepared by Dr Peter Kempthorne The epidural is placed while the child is asleep. A dose is given that will cover the surgery and then a more dilute solution is run as an infusion. The solution is the same as that used for adults. Ropivacaine 2mg/ml with 2mcg/ml of Fentanyl Occasionally this will be changed later to decrease a side effect, eg motorblock. The infusion rate ranges between 0.2 and 0.5 mls/kg/hr The epidural infusion is useful for children of all ages and the general principles discussed in the adult section apply to children. The biggest differences are: 1. The young child cannot give good information for assessment of level. 2. Children below the age of about eight show no hypotension associated with sympathetic blockade. They are already fully vasodilated unless there is shock so the administration of a sympathetic blockade does not cause hypotension. 3. The greater activity of young children means that extra care is needed with securing the epidural catheter. 4. The younger and more active the child, the more likely that local anaesthetic will leak out around the catheter. This does not mean that the block is ineffective but it does lead to loosening of the dressing etc. The other effect is that the infusion rate may have to be increased to 0.5 ml/kg/hr to cope with the leak. Rates above this in the presence of excessive leak should be avoided in case the leak later stops causing a rise in the level of blockade. 5. The main person to turn to for help with the epidural in a child is one of the Paediatric Anaesthetists, preferably the one who placed the epidural or the Acute Pain Service Nurse. (Beep 8114). At night the Anaesthetic Registrar (Beep 8212) may be available but is likely to be busy. The Paediatric Anaesthetist on call is more likely to be available. In the case of a dangerous problem call the Paediatric Registrar or the ICU Registrar immediately. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 14 11. COMMON DRUGS USED IN EPIDURAL INFUSIONS The epidural space is used because it allows drugs to be injected near to the spinal cord and the nerves surrounding it. When opioids are administered epidurally, pain relief is produced by the drug that is present in the spinal cord and not that in the plasma. The drug diffuses slowly into the subarachnoid space and then passes to opioid receptors in the dorsal horn of the spinal cord. Opioid analgesics are thought to block the release of substance P when they bind to opioid receptors in the dorsal horn therefore blocking the transmission of pain impulses to the cerebra cortex. Epidural administration of opioids has a more prolonged effect since the drug must diffuse out of the CSF into the blood before it can be excreted via the liver and kidneys. The analgesic effect is mainly confined to segmented spread across the spinal nerves that correspond to the site of entry into the epidural space. Local anaesthetics block the conduction of nerve impulses while narcotics only interfere with pain impulses. The most common opioid used in epidural analgesia is Fentanyl. At Christchurch Hospital Fentanyl is usually combined with a local anaesthetic such as Ropivacaine as this combination has been reported to produce a synergistic effect and reduce the incidence of side effects. 11.1 Local Anaesthetic (LA) Mechanism of Action Local anaesthesia works by pharmacologically blocking the nerve supply to a certain part of the body. This is achieved by reversibly interrupting the conduction of impulses along nerve fibres. The nerve axon has a membrane through which sodium ions (Na+) and potassium ions (K+) can pass. When no messages travel along these nerve fibres, they are said to be in a resting state. In the resting state the fibres are polarised, and have higher concentrations of Na+ outside the cells and higher concentrations of K+ inside. Generation of a nerve impulse (termed “propagation”) involves a depolarisationrepolarisation wave travelling along the nerve fibre. Depolarisation is caused by a flow of Na+ from outside the membrane of a nerve fibre through sodium channels to the inside. This ionic imbalance is rectified by ionic „pumps‟, which allow more K+ to flow out of the nerve fibre thus resulting in a repolarisation. Repolarisation is the reverse of depolarisation, with more K+ flowing out of the nerve fibres than Na+ in. Each depolarisation-repolarisation that occurs causes an adjacent depolarisation, which propagates the depolarisation-repolarisation wave along the nerve fibre. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 15 Regional anaesthetics prevent nerve depolarisation by preventing the sodium channels from opening. This effectively blocks nerve impulse progagation. There are a number of different types of nerve fibres which vary in size and function Table Two: Nerve Fibre Class, Size and Function Class A-alpha (A) Size Largest A-beta (A) A-gamma (A) A-delta (A) B C (unmyelinated) Smallest Function Motor, proprioception (position sense) Touch/pressure, motor Muscle spindle tone Pain/temperature Preganglionic autonomic Pain/temperature The ease with which a nerve fibre is blocked by a given concentration of local anaesthetic drug depends on its critical blocking length (the length that must be exposed to the drug in order for the nerve to become blocked) and on the accessibility of the nerve membrane binding site to the blocking agent. It has always been taught that smaller diameter nerve fibres are more easily blocked than larger diameter fibres. In fact, the actual diameter of the fibre is not itself important. However, the smaller diameter fibres have the smallest critical blocking length and are more easily accessed and blocked by local anaesthetic solutions. Nerve blockade is also frequency dependent; that is, active nerve fibres are more easily blocked than inactive ones. B fibres tend to be blocked before C fibres. This is probably because C fibres are usually arranged in Remak bundles, which may hamper diffusion of the local anaesthetic solution, and/or because the critical blocking length of B fibres is quite short. As the effect of any nerve block wears off, recovery of movement may precede recovery of sensation or sympathetic nerve function. This is of particular importance following epidural of spinal anaesthesia, when a patient may appear to have normal motor function yet may have incomplete return of sensation and a residual sympathetic block that leads to postural (orthostatic) hypotension. Bupivacaine (Marcain) 0.125% Used to effect a variable neural block usually including sympathetic, sensory and possibly motor nerves. This differential block pattern relates to the concentration of the LA with the motor nerve block requiring a higher concentration and the sympathetic nerves the least. The ideal is to block at least the pain pathways (will mean the more sensitive sympathetic nerves are blocked as well) while leaving the motor nerves unblocked. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 16 The effects of the various nerve blocks: Sympathetic nerves: Vasodilation, sweating and heat loss. Results in drop in blood pressure (BP), postural hypotension, warm dry periphery, and compensatory vasoconstriction in the upper limbs. Sensory nerves: [Have a range of sizes for the various modalities.] In order from small to larger they are pain, temperature, touch, pressure, and proprioception requiring increasing concentration of LA to effect blockade. Again, a wide variable block of some or all of these fibres may be present. Pain and temperature fibres are approximately the same size so pain fibre block can be checked by temperature testing. Complete block will remove pressure sense so regular 2 hourly position changes are necessary to avoid pressure areas developing eg blisters on heels. Sensory blockade is recorded by the regular documentation of upper and lower dermatome levels. Motor nerves: Results in loss of motor power within the blockade segment if the concentration of LA is high enough. Eg a thoracic block should only effect the thoracic and abdominal muscles/myotomes innervated by the thoracic nerves. Lumbar epidurals will affect the lower limbs more. This is very important when considering mobilisation. The extent of the motor block can be assessed by use of the Bromage scale for motor blockade in the lower limbs. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 17 Bromage Scale 0 No Block 0% 1 Partial 33% 2 Almost complete 66% 3 Complete 100% Full flexion of knees and feet possible Just able to flex knees, still full flexion of feet possible. Unable to flex knees. Still flexion of feet. Unable to move legs or feet. Figure Six: Bromage Scale S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 18 Ropivacaine (Naropin) 2 mg/ml Of a similar structure and potency to Bupivacaine, Ropivacaine has a similar onset and duration of action to Bupivacaine but is less cardiotoxic. In concentrations producing comparable analgesia, it results in less motor blockade than Bupivacaine. 11.2 Opioid Agents for example Fentanyl (Sublimaze) 2mcg/ml Affect antinociception by their action at opioid receptors at nerve root, spinal cord and brain stem sites. Does not block the other modalities as described above under LA block so there is no effect on BP or muscle function. However, they can cause nausea, vomiting, itch, urinary retention and respiratory depression. The risk of respiratory depression, although very rare, necessitates the regular monitoring and recording of respiratory rate and more importantly sedation levels. Fentanyl is considered to be a relatively lipid soluble opioid. As such it is taken up more readily by the neural tissues at the particular epidural level where placed. Over time it will eventually spread through the CSF towards the brain stem where the respiratory centre is located. More water soluble opioids such as morphine will spread more rapidly within the CSF because they are not absorbed so readily by neural tissue. 11.3 Alpha Agonist for example Adrenaline (Epipine) 0.2ml 1:1000 Has two effects: vasoconstriction (limits the vascular uptake of agents used); and antinociception. The latter is achieved at a local spinal cord level by neurotransmitter/receptor interaction. It augments the analgesic action of the other agents. Adrenaline containing LA is useful when giving a test or top-up dose to check if the catheter is in a vein. This will be indicated by an immediate and significant tachycardia. NB: Adrenaline is not required to be added when using Ropivacaine. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 19 Clonidine (Catapres) 150ug/ml Analgesia results from its action at alpha receptors in spinal cord dorsal horn. Systemic absorption can cause hypotension. Is a useful addition to the analgesic armamentarium especially as a top up agent for resistant pain. 11.4 Opiate Antagonists for example Narcan (naloxone) 0.4 mg/ml ampoule Indications: An opioid antagonist counteracts the effects of opiates. Given alone it has no clinically useful effects. Reverses respiratory depression, but maintains some analgesia. Problems/Side Effects: 1. Short duration of action (< 1 hour), therefore risk of renarcotisation. 2. Produces withdrawal in narcotic tolerant/dependent people. 3. Can produce vomiting and emergence of delirium. Rare Complications: Significant cardiovascular function with/ without prior narcotisation. Reported include systemic hypertension Pulmonary oedema Ruptured cerebral aneurism Atrial and ventricular arrhythmias. Administered as prescribed Note: Reversal with Narcan can herald a return of patient‟s pain. 11.5 Vasopressors for example Ephedrine (Ephedrine Sulphate) 30mg/ml Acts as a Vasoconstricter and a cardiac accelerant. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 20 Hypotension ± bradycardia May be secondary to sympathetic block of epidural Hypovolaemia A vasovagal response Postural Rarely LA toxicity A medical complication Medical Staff treat according to the cause, eg Ephedrine 5mg IV for hypotension from sympathetic block, volume expansion for hypovolaemia, etc. Do not automatically assume hypotension is due to epidural block alone. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 21 EPIDURAL LOCAL ANAESTHETICS Category Drug Local Anaesthetic Bupivacaine 0.125% 100ml polybag 200ml polybag Local Anaesthetic Ropivacaine 2mg/ml Recommended Dose Use 200ml polybag at rate prescribed Use 200ml polybag at rate prescribed Route via epidural line via epidural line Authorisation Infusion prescription Adult epidural infusion analgesia sheet (QMRO221) Infusion prescription Adult epidural infusion analgesia sheet (QMRO221) INTRAVENOUS ANTAGONISTS AND VASOPRESSORS (ADULTS) Opiate Antagonist Narcan (Naloxone) 0.4mg/ml 0.1mg and repeat as necessary Intravenously Vasopressor Ephedrine 30mg/ml 5mg and repeat as necessary Intravenously Adult epidural infusion analgesia sheet (QMRO221) Medical staff authorisation only Table Three S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 22 DRUGS USED WITH CHILDREN Category Local Anaesthetic Drug Ropivacaine 200 ml polybag premixed with Fentanyl 2mcg/ml Recommended Dose Use 200ml polybag at rate prescribed Route Epidural Opioid Agents Fentanyl 2mcg/ml (already premixed in bag) 2mcg/ml NB for children under 6 months of age 1mcg/ml is sometimes prescribed Epidural Alpha Agonist Clonidine 150mcg/ml 150mcg 1.5mcg/ml Epidural (add to bag) Opiate Antagonist Narcan (Naloxone) 0.4mg/ml Dose is approximately 0.1mg IV and 0.04mg/kg IM Intravenously or Intramuscularly Simple analgesic Paracetamol Route as prescribed Authorisation Infusion Prescription Paediatric epidural analgesia infusion sheet (QMRO166) As prescribed by Anaesthetist on Paediatric epidural analgesia infusion sheet (QMR0166) As prescribed by Anaesthetist on Paediatric epidural analgesia infusion sheet (QMR0166) As prescribed by Anaesthetist on Paediatric epidural analgesia infusion sheet (QMR0166) Dose as prescribed by medical staff (usually 20mg per Kg) Table Four S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 23 12. RESCUE REGIME RECOMMENDED BY APMS Applies mainly to NON PCEA infusions ie INTRAVENOUS opioid use if On Call / Duty Anaesthetist unable to come immediately and administer an Epidural Top Up. Procedure/Guidelines to follow for break through pain when Duty / On Call Anaesthetist is unable to come and perform an epidural top up: 1. Leave epidural running. 2. Contact on-call/Duty Anaesthetist ASAP 3. Discuss situation, plus details of IV Opioid prescription, if charted, on MR4 4. After being authorised, use the IV Opioid prescription charted on MR4. 5. If there is no IV Opioid rescue regime charted in the MR 4 it will need to be. Recommended guidelines for a rescue regime to be charted would be: a) Contact appropriate Medical Staff (ie Duty House Surgeon) b) Appropriate dose of IV Morphine or Pethidine (Morphine is the preferred agent unless contraindicated). c) Adult Dose: 0.5 – 2 mg Morphine or 10-20 mg Pethidine IV prn every 5 minutes to analgesia and respiratory rate > 10. After this IV Opioid loading monitor respiratory rate and sedation score at 20 minute intervals until epidural is reassessed. NB: At the time of the epidural being assessed, if an epidural top-up is given be aware that this may accentuate the effect of the IV opioid previously given and special vigilance is required to note respiratory depression/arrest. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 24 13. PROCEDURES FOR NURSING MANAGEMENT Refer to: Epidural Standards and Procedures, Post Operative Patients “Nursing Procedures Volume 12” For ease of reference, this is reproduced as Appendix A Other useful policy references : Pressure Area Prevention – Canterbury DHB, Christchurch Hospital “Nursing Procedures Volume E” Procedure for Anti-embolic Stockings Canterbury DHB, Christchurch Hospital “Nursing Procedures Volume 6E” S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 25 14. PROMOTING MOBILISATION Mobilisation maximises rehabilitation from surgery. The effects of EIA relating to mobilisation are: The degree of motor block will depend on the extent and density of the block. A thoracic epidural effecting only the thoracic segments should not cause significant weakness in the legs. A lumbar epidural commonly will, as well as possibly blocking the bladder function requiring the placement of a urinary catheter. The sympathetic block will cause vasodilation below the block so postural hypotension will occur. Block of proprioception will result in unsteadiness through lack of position sense. Postural hypotension may be confused with hypotension caused by hypovolaemia. Keeping the above in mind, proceed as follows: Check the sensory level including position sense. Check muscle power around the knee and ankle using the Bromage Scale. Check there is no hypovolaemia either from overt or concealed blood loss. Examine the patient for evidence of sympathetic block (warm, dry feet). Record a supine Blood Pressure. If this is considered adequate proceed to gently sit the patient up and repeat the BP noting any change from that of supine. If no postural hypotension: Proceed to mobilise and if at any stage the patient becomes symptomatic of low BP, assume the supine position and reassess. If there is postural hypotension: A systolic drop of more than 20-30 mm Hg and the patient is symptomatic (weak and lightheaded etc) then you may not be able to go on to the erect position. Return the patient supine. If there is no significant postural hypotension in the sitting position then proceed to stand the patient and repeat the BP. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 26 Remember that even if there is no problem with postural hypotension, the patient may still need to be supported during mobilisation if there is a block of the proprioceptive nerve fibres and two nurses may be required for this support. If there are any questions about mobilisation consult the APMS. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 27 15. PATIENT CONTROLLED EPIDURAL ANALGESIA (PCEA) : AN INTRODUCTION TO TECHNIQUES AND GUIDELINES Philosophy PCEA in some respects is quite different to Intravenous Patient Controlled Analgesia. With IV PCA the patient is instructed to push the button before a painful procedure occurs, eg mobilising physiotherapy, in other words in anticipation of pain occurring or becoming worse. Whereas with PCEA the patient is instructed not to push the button unless pain is actually present. The rationale for this is we don‟t want the patient using the PCEA mode frequently and possibly increasing the height of the dermatome block level if it is not necessary. Rationale Our current pumps have a PCEA function and its introduction has been intended. This will be consistent with other centres practice, maximise the efficiency of this modality and hopefully reduce the call-out top up rate. Patient Selection At the commencement this will be determined by the APMS. The reasoning for this is to introduce this new modality in a controlled-as-possible way. This will make things as comfortable as possible for all involved. Later when familiarity is achieved the selection and commencement process will be relaxed. For instance, at first, we will most likely commence PCEA following the Pain Round the morning after surgery if the patient is stable and an appropriate candidate. Set up and Monitoring As per PCEA GUIDE laminated chart attached to the epidural stand. Essentially the monitoring is the same as with an EIA with the exception that the dermatomes will be determined 2 hourly and not 4 hourly “if the parameters have been stable” (this may be relaxed back to 4 hourly in the future, all going well). The observations required are detailed in the EIA Treatment Sheet (QMRO221). The overall technique will require familiarisation from a number of perspectives. For instances, noting the frequency of PCEA “injections” (and “attempts”) as a basis for increasing the infusion rate if necessary. History button will reveal injection/attempts (record and document these along with Q2 hourly recordings. Injection/attempts shift total should be “zeroed” at the end of each eight hour shift (use reset 1. reset shift). S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 28 16. ASSESSING DERMATOME SENSORY BLOCK LEVELS The Anaesthetist will have charted on the Epidural Infusion Analgesia Treatment Sheet, QMR0221 what they deem to be an acceptable height for the dermatome block level. This will often differ slightly from patient to patient depending usually on the type of surgery performed and the insertion level of the epidural catheter. For example patients undergoing a thoracic procedure will have a high epidural catheter insertion whereas patients undergoing say an orthopaedic procedure will have a low epidural catheter insertion. As a general rule of thumb, the higher the epidural catheter insertion point, the higher the sensory block will rise although this is influenced by the rate at which the infusion is being delivered. There are several points that are important to note about dermatome block levels and their measurement. Firstly, always use ice to measure the sensory block level, NOT pinprick or pinch. Ice is ideal because pain and temperature fibres are approximately the same size and pain fibre block can be checked by temperature testing. There have been some cases documented in the literature where pinprick and pinch testing have resulted in severe skin damage manifesting 24-36 hours later (especially in elderly patients where skin tends to be fragile and easily bruised). Before assessing the level of the block the patient needs to have a comparison of sensation. Press the ice against the patient‟s inside wrist or cheek so they will be able to determine the difference in sensation from cold to numbness. Unilateral Block Test both sides of the patient‟s body with the ice, when one side only has sensory loss, this is called a unilateral block. This is usually caused by the epidural catheter moving off to one side and there are some strategies we can employ to try and compensate for this. Obviously if the side that is well blocked is also the location of the surgical procedure and the patient has no pain then the fact the block is unilateral is of no real concern, however this won‟t always be the case. Turn the patient onto their painful side ie the side that is not being blocked, gravity can sometimes help spread the local anaesthetic across. Also inform the APMS or Duty Anaesthetist as the patient will probably need a “top up” bolus dose to be administered. Another strategy the APMS or Duty Anaesthetist may employ is to pull the epidural catheter back slightly (usually 1 or 2 cm) which may resolve the problem however to do this necessitates taking the epidural catheter dressing down which is not done lightly. Pulling the epidural catheter back is also one of the instances where the importance of “Depth to Space” measurement (page 14) becomes relevant. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 29 High Sensory Block If the sensory block level exceeds the acceptable height charted on the Epidural Infusion Sheet by the Anaesthetist then the patient should be sat up as this may drop the block level to some degree and the APMS or duty Anaesthetist notified regarding orders to decrease or possibly cease the infusion. Watch your vital sign recordings. Low Sensory Block If the block is below the level of the wound increase the epidural infusion rate (within the parameters prescribed) and notify the APMS or Duty Anaesthetist. The patient will almost certainly need to have a “top up” bolus dose administered. “Patchy” Sensory Block If he blocked area is becoming ill defined or “patchy” notify the APMS or Duty Anaesthetist. Increase the epidural infusion rate (within the parameters described). “Patchy” blocks are nearly always an early sign that the patient is going to lose their dermatome block levels altogether and the APMS usually administers a “top up” bolus dose. General Remember when measuring dermatome block levels that you are looking for an upper and lower block level (bilaterally). If you need to increase or decrease the epidural infusion rate (within prescribed parameters) do so in multiples of two. You can nearly always discern if a patient has a good sympathetic block by feeling their feet. They will feel warm to the touch (vasodilation) and dry (sweat gland inhibition). Both of these factors are due to the action of the local anaesthetic. Be very careful with hot drinks etc around patients on epidural infusion. It is easy for them to unknowingly suffer a severe burn to the blocked area. Heated wheatbags are particularly dangerous and should never be used on patients with epidural infusions. Some patients while having full motor power to their legs may experience block of proprioception when mobilising. This is an inability to ascertain where their feet are in relation to the ground caused by altered sensation and lack of position sense which leads to unsteadiness. (Some patients describe the sensation as similar to trying to walk on water). It is important to assist these patients with mobilising. Children present some special challenges in terms of assessing dermatome levels. It has to be accepted that with the young child and babies dermatome assessment may not be possible. One strategy that may be useful is to observe for flinch response to ice. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 30 cervical thoracic lumbar sacral Key dermatome levels Landmark Little finger Nipple line Tip of xiphoid Umbilicus Inguinal ligament Level C8 T4-5 T7 T10 T12 Significance Cardiac accelerator fibres (T1-4) blocked Possibility of cardio-accelerator blockade Splanchnics (T5-L1) may become blocked Sympathetic blockade limited to lower limbs Figure Seven : Dermatome Chart S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 31 17. “BRIDGING” FROM THE EPIDURAL Leave epidural catheter in situ. Continue to record regular pain assessments and monitoring. Feed and mobilise as consistent with post op progress. Continue with the regular Paracetamol ± NSAID doses already instituted. Anticipate being able to analgese patient adequately with additional analgesics/means, unless pain levels declare themselves to be severe. Trend initially towards regular dosing moving to “prn” as pain subsides, 18. CHANGING THE EPIDURAL INFUSION BAG 19. REMOVAL OF THE EPIDURAL CATHETER Remove catheter only on authorisation of APMS/Duty Anaesthetist. The recommended time for removal for patients receiving anticoagulants (clexane) is 22 hrs from the last dose (ie 2 hours before the next dose. The patient must be positioned on their side with back slightly flexed. This is an aseptic procedure and the use of sterile gloves is required. Catheter is gently and steadily withdrawn NOTE Force should NOT be used. If resistance is felt, do not continue with the removal and notify APMS or duty anaesthetist. The tip of the epidural catheter should be examined on removal to check for intactness. Tip is coloured blue and blunted. If catheter not intact notify APMS or duty anaesthetist. If there is any signs of infection/inflammation swab site and send swab and the Epidural catheter tip for bacteriology culture and notify APMS . Document removal of the catheter and any variances (see above point) in the patients clinical record. Clean site with Chlorhexidine solution and apply a sterile dry dressing to the site for twelve hours-document time for dressing removal in the patients care plan. 20. POTENTIAL COMPLICATIONS- EPIDURAL ADMINISTRATION ERROR Dedicated GEMSTAR YELLOW COLUR CODED volumetric pump is the ONLY pump to be used for the delivery of Epidural Infusions. Dedicated GEMSTAR YELLOW COLOUR CODED is the ONLY tubing to be used . Filter is secured at chest by IV 3000 transparent dressing and labelled as EPIDURAL Secure tubing and filter on opposite side of patients neck to any central line. Only medications prescribed on the epidural prescription sheets QMR0221 (Adult) or QMR0166 (children) are to be administered via the epidural . Two registered nurses must check the drugs to be administered and the correct programming of the epidural pump. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 32 RESPIRATORY DEPRESSION AND SEDATION Dependant on dose and volume of opioids used. No other opioids are to be given concurrently unless authorised by anaesthetist Risk of respiratory depression increases with higher thoracic catheter placement Ensure patient has a patent IV leur in situ for administration of reversal drug if required. It is recommended that a oxygen at 2lt is charted for a minimum of 24 hrs for all epidural patients. Recordings/observations as per epidural infusion treatment sheet. EPIDURAL HAEMATOMA Rare but serious complication. May occur at insertion/removal of catheter or at any time during the epidural infusion Following authorisation from the APMS the ideal time for removal of epidural catheter for patients on subcutaneous clexane anticoagulant is 22hrs from the last dose (ie 2 hrs before the next dose is due). Any symptomlogy such as swelling at epidural site, back pain, loss of motor power, contact APMS or Duty Anaesthetist. EPIDURAL CATHETER MIGRATION (eg thru the dura into csf/blood vessel) Rare Rapidly ascending wide dermatome block. Vital signs may indicate a decrease in BP pulse and respirations STOP epidural infusion Contact APMS or Duty Anaesthetist as reversal agents may be required. EPIDURAL ABCESS Rare Usually caused by skin staphylococcus tracking up the epidural catheter. Higher risk patients are those who are or have been: immunocompromised/onsteroids/diabetic. Symptoms. -Back pain (exquisite to palpation) -Radiating radicular pain from the spine to the chest -Pus at epidural site and/or pyrexia -Loss of bowel or bladder function (late symptom) -Can be a late presentation after epidural has ceased. Diagnosis is through history and physical examination Definitive diagnosis is made by MRI scan Treatment- antibiotic therapy and/or surgical decompression.of spine. INFECTION AT EPIDURAL SITE Incidence risk rises after three days of therapy Exposure of epidural site to air will usually result in infection within 34-36 hrs, site must be cleaned with chlorhexidine and then redressed S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 33 After consultation with APMS/Duty Anaesthetist remove epidural catheter if infection at site present. Swab epidural site for culture and also send epidural catheter tip to lab for culture. (Clexane dosage timing will be a factor in timing of epidural catheter removal). Observe epidural site for 3-4 days post removal to ensure healing is occurring (APMS will also follow up patient post catheter removal). Preventative Measures: Window dressing over site Biopatch in situ Premixed infusion bags Do not disconnect/reconnect epidural tubing Three day therapy time frame (usually) HIGH BLOCK Any dermatome block above the level prescribed on the QMR0221 EPIDURAL INFUSION SHEET Posture will affect block height level. Sit patient up as this may drop the block level to some degree. Contact APMS/Duty Anaesthetist regarding orders to decrease or possibly cease epidural infusion. BREAKTHROUGH PAIN Check integrity of system Unless contraindicated APMS recommend that all adult patients on epidural infusions have Paracetamol 1gm Q6hrly as prescribed. APMS/Duty Anaesthetist to be contacted to assess the patient and to administer a “topup” bolus of epidural solution if required. Increase epidural infusion rate as prescribed (recommend increase by 2ml only) Patient Controlled Epidural Analgesia may be an option. Posture may help the block spread (eg turn patient onto side that is sore). URINARY RETENTION Stopping the epidural infusion may resolve the issue. Patient may require urinary catheterisation. NAUSEA AND VOMITING This side effect is difficult to isolate as being caused by epidural infusion, antiemetic therapy is the mainstay of treatment. PRURITIS Can be caused by the opioid in epidural infusion solution, may be mild or severe For children (upon authorisation) the opioid is usually removed from the infusion solution, after this the itch usually resolves fairly rapidly. For adults usually pharmacological anti itch agents are used (eg low dose naloxone)The APMS/Duty Anaesthetist will need to be involved. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 34 SENSORY /MOTOR BLOCK Usually dependant upon level of epidural catheter placement. Bromage scale recordings as per QMRO221 Epidural Infusion Treatment Sheet. If a degree of motor blocking is present , pressure area care (esp heels) is paramount to prevent pressure sores developing Some motor impediment treatments the APMS may authorise include discontinuation of epidural infusion if no resolution after 24 hrs and re-siteing of catheter. HYPOTENSION Common problem post surgery with or without epidural Epidurals UNMASK fluid volume status. APMS may prescribe IV colloid agents. LEAKAGE AT SITE More common in children than adults. Main problem with leakage is it tends to lift the epidural site dressing. If patency of dressing becomes a real issue epidural may have to be abandoned. The best way to remedy a lifting epidural site dressing is to place more IV 3000 dressings over the top of the existing dressing thus securing it down Leakage can also be an early sign of epidural failure (mostly in adults). LOCAL ANAESTHETIC TOXICITY Rare May occur with inadvertent intravascular administration (eg epidural catheter moves out of position) If a patient develops any of the following signs and symptoms (they are usually progressive) contact APMS/Duty Anaesthetist. Tinnitus Light headedness Visual disturbances Muscular twitching Convulsions Decreased level of consciousness. POST DURAL PUCTURE HEADACHE This can occur when during the insertion of the epidural the needle has protruded past the epidural space and punctured the dura.The hole that has been made in the dura can cause a significant leaking of the cerebrospinal fluid. It is the leaking of this buffering fluid that can result in the patient experiencing a severe headache which can be accentuated by posture (ie sitting forward or standing up). The hole made in the dura will in most cases heal spontaneously over a period of a few days. Some will persist longer than this with 99% spontaneously healing within 1-2 weeks. Treatment Patients complaining of headache thought to be the result of a dural tap can be prescribed caffeine tablets 300mg 3-4 hrly prn until the headache subsides. Patients whose headache are slow to subside or are finding the convalescence restricting can undergo a “blood patch”. This involves the taking of a sterile sample of approximately 20 mls of the patients own blood and injecting it into the epidural space at the same level as the S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 35 previous epidural injection. This then creates a patch over the hole in the dura and in the majority of cases, eliminates the headache. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Prepared by Richard Craig, Clinical Nurse Specialist, APMS for Department of Nursing, Christchurch Hospital, Canterbury District Health Board Last Updated 2012-02-29 Page 36 APPENDIX C EPIDURAL INFUSION ANALGESIA – PATIENT EDUCATION FOR ADULTS What is an“Epidural”? An epidural is a method of pain relief where local anaesthetic is injected continuously through a fine plastic tube which has been placed in the back. The tip of the tube lies near the nerves transmitting pain sensations at the place where the nerves enter the backbone. Why have an Epidural? An epidural infusion can provide you with the best form of pain relief known to us. Commonly they are associated with childbirth but more recent advances in specialised care have seen them used in the postoperative setting. What are the Benefits? Potentially you will experience superior pain relief, fewer side effects, less drowsiness and be more clear headed after surgery. Also, epidural infusion pain relief can hasten recovery after surgery, patients enjoy greater comfort, get well faster and have fewer complications related to surgery. What are the Side Effects? In addition to preventing most of the pain epidurals may create some of the following: a cold, numb, heavy, weak or tingling feeling on the area where the epidural is working. A drop in blood pressure and/or heart rate which may cause dizziness especially when standing. Itching Nausea Inability to sense when the bladder is full; this may require a urinary catheter. These side effects are expected to wear off when the epidural is discontinued. How long will I have the Pain for? This is individual and often depends upon the surgery and your progress. Commonly epidural infusions remain in progress for 2 to 3 days. How will I be monitored? Your nurse will monitor you closely to ensure you get good pain relief and that side effects are kept to a minimum. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Last updated September 2009 This is done by: a) asking you to rate your level of comfort (0) no pain to (5) worst pain imaginable. b) by taking blood pressure, pulse and other observations which are done regularly while you are having the epidural. c) measuring the uppermost level of numbness you may feel which is called the “block level”. This is usually done with ice. (Refer to chart on back of pamphlet). d) Determining if you need assistance with moving and prevention of pressure sore formation. e) the Acute Pain Service will visit you once a day and together with your nurse ensure you are as comfortable as possible. How is it Removed? After discussion with the pain team the epidural infusion will be stopped. Provided you are comfortable the plastic tube will be pulled out about six hours later by your nurse. This is expected to be a quick painless procedure. Should pain occur within that time the epidural may need to be recommenced for another day or two. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Last updated September 2009 EPIDURAL INFUSION ANALGESIA – PATIENT EDUCATION FOR PARENT & CHILD What is an Epidural Epidurals traditionally have been associated more with labour and childbirth however in more recent times have been used to combat post operative pain following certain types of surgical procedures. An epidural is a method of pain relief where local anaesthetic is injected continuously through a fine plastic tube which has been placed in your child‟s back. The tip of the tube lies near the nerves transmitting pain sensations at the place where the nerves enter the backbone. What are the Benefits? Potentially your child will experience superior pain relief, fewer side effects, less drowsiness and be more clear headed after surgery. Also epidural infusion pain relief can hasten recovery after surgery, children enjoy greater comfort, get well faster and have fewer complications related to surgery. What are the Potential Side Effects? Some children may experience a generalised itching. This is usually caused by one of the opioid drugs used in the epidural infusion solution. It is important to let nursing staff know if you notice your child is distressed by itch so that treatment can be commenced. Nausea may be another side effect although this is rare. Should nausea occur it can usually be treated by removing the opioid component from the epidural infusion solution without compromising pain relief. Diminished bladder sensation caused by the local anaesthetic solution may necessitate a urinary catheter which will be removed following cessation of the epidural infusion. Numb heavy weak legs may occur again as a result of the local anaesthetic action, this can usually be resolved by altering the strength of the epidural infusion solution. How Long will the Epidural Stay in for? This usually depends upon the type and site of surgery however most children require the epidural infusion for about 48 hours following surgery. How Will my Child be Monitored Your child‟s nurse will monitor your child closely to ensure they get good pain relief and that side effects are kept to a minimum. This is done where applicable showing your child a series of faces depicting various stages of distress and asking them to point to the face which most closely depicts how they are feeling at the present moment. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Last updated September 2009 For the very young child we will be looking for non-verbal expressions of pain such as irritation, crying or restlessness. Your role as a parent is important in the assessment of your child‟s pain as no one will know your child better than you. Most parents can very quickly discern when their child is in pain. The Acute Pain Service will also visit your child at least once a day for the duration of the epidural infusion and together with the nurse ensure your child is as comfortable as possible How is the Epidural Removed? After discussion with the Acute Pain Service the epidural infusion will be stopped. Provided your child is comfortable the epidural catheter will be pulled out about four hours later by your child‟s nurse. This is a quick, painless procedure. ` S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Last updated September 2009 REFRENCES Macintyre P.E., Schug S.A., Scott D.A., Visser E.J., & Walker S.M. APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2010), Acute Pain Management: Scientific Evidence (3rd edition), ANZCA & FPM, Melbourne. Mcintyre, P. E., & Schug S. A., (2007). Acute pain management: A practical guide, 3rd Ed, London: Elsevier. S:\PMHDataLink\Division\SDU\COMMON\Competency Matrix\Self learning packages\epidural manual update march 2012 (2).doc Last updated September 2009