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Performance Improvement Mark Mosley, MD, MPH CME sponsored by Wesley Medical Center ESPA, Wesley Medical Center 550 North Hillside Wichita, KS 67214 Phone for copies: (316) 962-2313 WESLEY EMERGENCY DEPARTMENT THE QUEAS-E UPDATE (Quality, Uniformity, Education, Attitude, and Service - in Emergencies) SPECIAL EDITION – PAIN MANAGEMENT REVIEW Issue 88 “A professional approach toward pain” Here is a review of pain management as it relates to the ER. We should begin with a few reminders: Pain is the most common condition seen in the ER. ERs are lousy at offering pain medications promptly or in adequate doses.1,2 Severe pain is more clinically meaningful than elevated blood pressure, sinus tachycardia, or even fever at triage (pain is often the cause of elevated blood pressure and high heart rates). Acute severe pain is often (but not always) easy for anyone to recognize objectively (so there is no excuse for second guessing a patient with an objective measure). Pain and fear are often synergistic (treating one may help the other). Pain and fear can often be soothed nonpharmacologically as well as pharmacologically. Most medical professionals have almost no formal training dedicated to acute pain management. The number one patient satisfier in the ER is prompt control of pain. The majority of conditions, even in an emergency setting, are self-limiting and need only pain and fear control. September 2010 If an ER did nothing except excellent comfort and reasonable information that the patient agrees with – we would satisfy the majority of patients using much less time and resources with rare harm and excellent outcomes! If this sounds preposterous, consider what we say to each other every day “Most people who come to the ER don’t need to be here.” Consider all of the studies that prove that ER staff do pain management poorly often because we don’t believe a patient should get real pain medication unless they have a real problem (critically emergent). What if we spun this information in a positive direction? What if we all believed that most patients need to come to the ER to get accurate information to relieve fear and they need to come to the ER to get pain control because our current legal and medical environment does not allow this to happen by phone or happen immediately at an office. Instead of blaming patients who come to the ER (or who are sent by others), what if we welcomed them to the best place to have pain and fear relieved emergently by medical experts who are trained and excel in acute pain management and communication. Instead of trying to chase patients away from the ER (which by the way is not working) what if we promoted it as the best current answer for patients who need immediate answers and relief? PAIN SCORES: “The positives and the problems” The most positive things about pain scores are: Everyone gets one putting pain control as a front door top priority. The adult patient defines it (usually) which recognizes the subjective nature of pain and prompts an individualized response. There are several problems with pain scores: Staff refuse to believe a 10/10 if the patient doesn’t look like a “10”. Because of the subjective nature of pain, a “7” is only a relative parameter for that particular patient and is a poor comparison to another person’s “7”. So knowing what to do with a “7” cannot be standardized. The scale measurement has 10 equal increments when in reality moving from a “10” to a “7” may be much more significant than moving from a “7” to a “1”. The scale assumes a “normal” of “0” when many people may have a “normal” pain of “5”. The height of the pain score does not predict who does or does not want pain medications.3 (What does one do with a “6” who “refuses pain medication”?) “Pain” is still viewed culturally as a negative. (eg We write “patient still complains of pain”. We are pleased by the patient who says “I don’t want any more”.) Advocating for more pain treatment goes against the culture. “Pain scores” imply “pain meds” and may miss non-pharmacological strategies to provide comfort from pain or fear. Page 2 My wish is that we replace the “pain score” which has negative connotation of what the patient has, to a “comfort level” which has a positive connotation towards what the provider can do. A “comfort level” would also imply that other measures should be done in addition to “pain meds”. The question would be “What number would you put on your level of comfort right now with ‘10’ being your normal level of comfort and ‘0’ being extreme discomfort?” (We would substitute “chest discomfort” with “chest pain”.) The next question would always be “What are you hoping we could do to make you more comfortable?” (We might be surprised by “I don’t want any pain medications, I just want to know…”) Making patients “more comfortable” is much more acceptable and perhaps much easier than making patients “pain-free”. COMMUNICATION: “Patient control begins the relief” After asking the patient’s input for “What can we do to make you feel more comfortable?” The companion question is “By what route would you like this – by mouth, a shot in the muscle or an IV?” One should not assume the route based upon a number or your own assumptions about how much pain they look like they are in. One can then negotiate an opiod versus a non-opiod and if they have a ride home. Allow the patient the courtesy of a shared decision-making process. By giving the patient control over the route, you actually decrease fear and pain. The medical professional should generally choose the drug; but the patient should be given control of the route. SERVICE: “Non-pharmacological comfort measures” The reticular activating system (RAS) is that part of the brain that “ramps up” one’s level of awareness – kind of a neurological volume button. By turning down the RAS, fear, nausea and pain, as well as blood pressure and heart rate deescalate. NON-OPIOD ANALGESIA: “All about NSAIDs” While NSAIDs are the most popular non-opiod distributed and recommended coming out of an ER, there is a lot of misinformation about NSAIDs: Ways of non-pharmacologically turning down the RAS include: never allowing a patient to remain on a backboard in the ER repositioning the patient on the bed with pillows always turning down the lights (if it’s ok with the patient) speaking in a calm soothing voice with eye contact offering a warm blanket a gentle touch of someone’s hand with a word of reassurance “We are here to help you – you’ve got a great group of nurses and doctors here” giving the patient (or loved one) a call button (form of control) closing the doors (enough to create a sound block) TV (cartoons for children) can be a huge distraction and source of comfort for some quick to acknowledge and empathize with the patient’s discomfort The front line of “pain management” can be done on every patient without a medication and even without a doctor’s order. Page 3 Most arthritis, tendonitis, sprains and strains do not respond to antiinflammatories any better than non antiinflammatories (eg OA of knee, ankle sprains, etc).4,5,6,7 NSAIDs may be advantageous for preemptively reducing hollow viscous pain which is prostaglandin mediated (eg kidney stone, dysmennorhea and maybe gall bladder would be the primary ER conditions) though this has never been proven.8 One category of NSAID is not superior to another category (although some individuals may respond to one category better than another).9 Parenteral ketorolac (Toradol) is NOT superior to oral ibuprofen.10,11,12,13 For adults, 400mg ibuprofen is as effective as 800mg for pain relief.14 There is no benefit and no place for a COX-2 inhibitor (Celebrex) in the ER (or any other place in medicine).15 Newer parenteral NSAIDs (Calador) will unlikely be any more effective. NSAIDs are the most harmful drugs used in the US16 (because they are used so widely) and are known to worsen CHF, inhibit the effects of some anti-hypertensives, delay bone healing, and even occasionally enhance heart attack risk in addition to causing GI bleeds and renal dysfunction. No NSAIDs for fractures (proven harmful for post-op back surgery and unstudied in nonoperative long bone fractures).17 We should never write in our dismissals “ibuprofen for pain” without limiting the period of time (eg “for no more than 5 days”). NON-OPIODS: “Tramadol is usually deception” Tramadol (or any other combination with Tramadol) has not been shown to be any more effective than ibuprofen.18,19,20 The side effect profile is high with headache, dizziness and nausea being common. The cost of trade name Tramadol (like Ultracet) is much more expensive than most opiods. Tramadol’s only place in the ER may be a recovered addict who wants something else besides acetaminophen or NSAIDs but does not want an opiod (and still does not guarantee that there is not abuse potential). Tramadol is usually a form of pharmacological deception by a provider who does not want to prescribe an opiod but is too afraid to honestly confront the patient. “Tramadol allergy” is usually deception by the patient to get an opiod. ORAL OPIODS: “Think oxycodone 5.0” Darvocet is no better than acetaminophen with many more side effects.21 Codeine is less effective, has more side effects, and is more expensive than hydrocodone, oxycodone or hydromorphone.22 A large percentage of caucasian (20-30%) and Arabs and a lower percentage of Asians and Africans have a genetic opiod metabolic defect and metabolize codeine (and morphine) unreliably.23 While no good head to head studies exist comparing hydrocodone to oxycodone; oxycodone and hydromorphone in theory may metabolize more consistently. Oxycodone 5.0 is essentially the same price as hydrocodone 5.0 (about $15-20 for 30 tablets). Hydromorphone 4mg tablets are equally inexpensive. 5.0 can be broken in half or added together to make 7.5 or 10. Writing for 1/2 – 2 tablets every 4 hours allows more flexibility for hydrocodone or oxycodone. Page 4 Oxycodone with acetaminophen is a good choice for acute pain. Hydromorphone provides a good additional rescue (because it contains no acetaminophen). Stool softeners should be recommended routinely for patients prescribed hydrocodone, oxycodone or hydromorphone. IM MYTHS It is not necessarily true that IM medications work faster than oral medications. Oral meds connect in about 15-30 minutes and peak at about 1-2 hours. IM meds are unreliable and unpredictable. It is not true that IM medications last longer than IV meds. It is true that IM medications are faster for the nurse than IV, but this does not mean it is more effective than either IV (or po) for the patient. IM meds may be the best choice for the patient if they are a very difficult IV stick and the patient requests the IM route. IV OPIODS: “Fentanyl and hydromorphone” Morphine has largely been replaced by fentanyl and hydromorphone because they may have less pruritis, and less nausea and are not apparently affected by genetic opiod metabolic effects (GOMD). Adult patients > 70 years old should use 25-50% of an opiod dose.24 Fentanyl 100 micrograms IV (50 micrograms for > 70 yr old) is an excellent choice in the ER for emergent severe pain due to its immediate onset of action (1 min) and its short duration (about 30 min). Hydromorphone (Dilaudid) 1mg IV (0.5mg IV for > 70 yr old) is an excellent combination with Fentanyl because it kicks in well about the time Fentanyl begins to dissipate and lasts for 4-6 hours. IV OPIOD MYTHS Page 5 “Biliary spasm” is a popular pimp question to the medical student on the surgery rotation but has no good human clinical studies to prove one opiod is better than another.25 Anti-emetics are not required or suggested routinely with opiods. They do not improve pain control and may increase respiratory depression. The pruritis associated with opiods (particularly morphine) is often treated with antihistamines in spite of no literature supporting their benefit (eg interestingly Ondansetron was beneficial in one study).26 Patients given opiods are not automatically ineligible or incompetent to sign surgical permits or informed consents. (A mini-mental status exam not whether someone has received a drug determines competence in the ER.)27 Breastfeeding mothers who receive an opiod do not have to waste their breast milk for a feeding or two (though the study was very small that said the opiod does not affect the baby clinically).28 Obese patients do not need more opiod (in fact if they snore, they may be at risk for obstructive sleep apnea [OSA] and actually need less). AVOID TITRATION IN THE ER Titration of IV opiods in the ER goes against the recommendations of The Joint Commission. For the patient still in pain with a titration order (eg morphine 2-10mg), the ordering physician will not know if the patient has been given only 2mg with a hesitant nurse or 10mg and requires more. ERs perform better that have pre-printed order sets with set amounts. >70 or OSA Fentanyl 100 micrograms IV Hydromorphone 1mg IV Fentanyl 50 micrograms IV Hydromorphone 0.5mg IV Repeat hydromorphone 1mg IV in 15 minutes if pain not well controlled (0.5mg hydromorphone if > 70 or OSA) *This 1+1 hydromorphone protocol resulted in 95% effectiveness with no clinically worrisome respiratory depression.29 ANTIEMETICS IN THE ER IV Phenergan is now black-boxed and should probably be avoided. IV Compazine and Reglan can both cause akesthesia (which may be difficult to recognize but goes away promptly with Benedryl). IV Ondansetron 4mg appears to be as efficacious as 8mg in the patient not receiving chemotherapy. No one antiemetic is more efficacious than another (including Decadron 4mg IV or Haldol) but Ondansetron is now generic and has less side effects.30 ADJUNCTIVE ANALGESICS: “Muscle relaxers unsupported” For patients with muscle spasms (not chronic spasticity from CP, etc) there is no good data which justifies the cost or side effects of “muscle relaxers” (eg Flexeril, Skelaxin, Robaxin, Valium, Soma, Norflex, etc).31,32,33 Muscle relaxers are often used as a substitute to avoid opiods but they have no analgesic properties, just sedation. ADJUNCTIVE ANALGESICS: “Neurontin off-label and suspect”34,35,36 Gabapentin does not have FDA approval for any pain condition except postherpetic neuralgia and diabetic peripheral neuropathy. Gabapentin is poorly bioavailable (27-60%) and must be pushbed to rather high doses for even marginal effect. The makers of Neurontin have admitted to criminal activity in marketing and deceiving physicians to use Neurontin for conditions that had no data. One of the primary pain experts in the country who advocated and promoted Neurontin admits to falsifying his data or having it ghost-written. Lyrica (pregabalin) is simply a precursor drug of gabapentin except it is outrageously expensive. Fibromyalgia is not neuropathic pain and Neurontin and Lyrica should not be advocated. All “neuropathy” is not the same as diabetic neuropathy. PROCEDURAL PAIN RELIEF PEARLS 2x2 gauze soaked in 2% viscous lidocaine and placed in the area of the dental block for 10 minutes before injection. Hurricaine spray (bupivicaine 20%) on the tonsil before 30 gauge infiltration of analgesia. Page 6 Warm viscous lidocaine before all foley caths in men or women (urojet), adult and children.37,38 Warm viscous lidocaine jelly down nare before NG (better yet avoid NGs altogether).39 LET with occlusion on wounds or small abrasions. Silvadene cream on large surface abrasions (lidocaine jelly burns too much). Refrigerants (eg Pain Ease) topical spray immediately before introducing 30 gauge infiltration of abscess. Use bupivicaine or lidocaine all the way down on LPs and not just for skin wheal. 30 gauge, warm analgesia, slow infiltration and can even buffer 1:10 with sodium bicarb. (30 gauges are not in kits) Use bupivicaine plus epi almost everywhere including fingers and toes40 – lasts much longer. J-tip is needleless air driven analgesia used for IV starts (popping can scare some children). Intranasal fentanyl (1.5 micrograms/kg) ½ dose atomized in each nare is an excellent quick analgesia to get films without an IV.41 Don’t let patients see all your needles and bottles. Draw everything up out of site. Hip traction doesn’t help.42 ADULT PSA: “Ketofol is a favorite” Propofol is an excellent choice for procedural sedation. Unfortunately it has no analgesic properties and its use in the ER creates a fair amount of apnea and hypotension. Ketamine is a dissociative anesthetic which increases blood pressure and does not depress breathing. Its contraindications in adults due to hallucinations and head trauma are overplayed and likely untrue. A low dose of propofol (0.4mg/kg) combined with a low dose of ketamine (0.3mg/kg) IV provides an excellent combination with high success, high safety, and quick turnaround.43 CRITICAL PAIN RELIEF Everyone intubated who has an adequate blood pressure needs anxiolysis and analgesia. In a study of 117 adults undergoing RSI who remained in the ED longer than 30 minutes after intubation, less than half received any analgesia and another fourth received trivial doses. Only 3% received good doses of both anxiolysis and analgesia.44 PEDIATRICS: “Painful memories” If you took a psychiatrically normal adult and wrapped them up in a straight jacket and then had people lay on them while the doctor did a procedure, your medical license and your institution would be at legal risk. In adults, this is called battery and torture. In children, we call them papoose boards! Why do we allow ourselves to do to children what we could not morally imagine doing to adults? How many of you, while forgetting the scalp laceration you had five years ago, can remember with vivid detail the laceration you had to have sewn up as a young child? How many muscle bound 6’5”, 25 year old men have you seen who when confronted with a tetanus shot act like a four year old? Why do you think that is? Childhood memory of pain is different. Pain and fear are inseparable especially in children. We should create an atmosphere of calm, comfort, and safety just as much as we create a bodily area of analgesia. We should do more procedural sedation and analgesia (PSA) with kids, not less. Throw away the papoose board! (Read the article.)45 Some believe I am overly zealous to use sedation and analgesia for rarely minor procedures like LPs, and small facial lacs, and small tweaks on the distal radius (that others swear “do just as well” with a hematoma block). But there is one huge factor that is misunderstood. We are not talking about the physical result of the procedure according to the doctor. We are considering the psychological trauma according to the child and his family. We fail to recognize that pain and fear in a child’s mind are often synonymous. So telling a weeping mother and her sweaty exhausted two year old that “he really didn’t feel any pain, he was just scared” – is a stupid statement. Furthermore, we now have very interesting proof that the pain and psychological experience of a child is remembered physiologically and may have long-term or even lifetime implications! We know that newborn males circumcised with adequate analgesia respond differently (better) at their 2 month immunizations than circumcised counterparts without analgesia. Page 7 TOXICOLOGY: “Illicit Methadone overdose – hard to diagnose and treat” Methadone is wrongly thought of as a “safer” opiod because it is used as part of treatment programs to wean people off other narcotics or drugs. If it is “safer”, it is because it is carefully monitored. Unfortunately, illicit Methadone use on the street is gaining popularity. And unlike many other narcotics and drugs, a quick urine drug screen may not identify Methadone. If a person does not admit to Methadone or is too out of it to tell someone, the treating physician will likely treat the illicit Methadone overdose just like the unknown narcotic overdose (pinpoint pupils, bradycardia, hypotension, hypothermia, somulent, etc). (cont’d on next page) (cont’d from previous page) The recommended approach toward unknown opiod overdose is low dose narcan (0.4mg) as to not put the patient into withdrawal. But this dose will likely not be enough to get a response for Methadone which may need up to 4-10mg! The routine EMS or ER doc will simply assume it is not an opiod because it appears to be a nonresponder with standard low dose narcan. I’m not sure of a way out of this one other than begging the patient to be honest if they’ve taken Methadone in what you believe to be an opiod overdose – because illicit Methadone overdose is very lethal. URINE DRUG SCREENS ARE BAD “LIE DETECTORS”46 Some providers use a “urine drug screen” to test honesty in a patient to determine whether to write a script for opiods. Trusting urine drug screens is very unreliable (except for maybe cocaine and marijuana). The urine test is also ok for morphine or codeine within the past 2-3 days (up to a week with heavier use). However, for semisynthetic opiods (hydrocodone, oxycodone) there are varying results. And synthetic opiods (Fentanyl, Methadone, hydromorphone, propoxyphene) have minimal cross-reactivity and may not be detected, especially at lower doses. There are plenty of both false positives and false negatives to make urine drug screens a bad “lie detector test”. PSYCHOLOGY/PHARMACOLOGY: “Addiction without substance”47 Pain is the most common condition in all of medicine – and definitely the most common in the ER. And yet few physicians have any significant formal training in acute pain management. And yet what diagnosis do we make with frequency in our ERs but “drug-seeking” and “addictive behavior”. But upon what training and education do we make such decisions? Where is the “substance” to our accusations? Let’s start with what addiction is not. It is not using a narcotic in escalating doses, this is physical tolerance. It is not withdrawing from a narcotic if you don’t get it, this is physical dependence. It is not necessarily a drug that you can’t do without psychologically – this is psychological dependence and is present in just about every diabetic. It is not necessarily a drug you get via illegal activity – in many countries you might be able to get a necessary medication only thru a black market. Addiction is also not necessarily defined by a drug that you use despite it causing physical harm – otherwise every person with dyspepsia from NSAIDS would be an addict. It is not even so easy as someone who lies to get pain medication – this is frequently done at some level because the medical profession is so bad at giving appropriate doses for acute pain (this is called pseudo-addiction where one manipulates to get the right therapy). There are also persons who have severe mental illness who misuse and abuse medications not to achieve some desired effect but rather due to their inabilities to maintain responsible behavior whether it be medicine related or not. (cont’d on next page) Page 8 (cont’d from previous page) There is good evidence to suggest that physical tolerance and physical dependence upon opiods does not translate into addictive behaviors. The idea that you will addict a normal individual by placing them on opiods for acute pain is completely unfounded. Even the myth that patients become euphoric who get opiods is extremely uncommon. In fact, dysphoria is much much more common with the administration of opiods. So if we can admit that most of us have many mis-definitions and misconceptions about “addiction”, now let’s attempt a better definition. I think the best definition I’ve ever been taught is “A repetitive pattern of using anything for the purpose it is not intended.” Whether alcohol, food, sex, work, exercise or pain medication, the definition works. So for ER acute pain management this becomes relatively easy. If you have objective parameters of injury or pain (even in a chronic pain patient): laceration, bruise, swelling, tachycardia, elevated blood pressure, vomiting, diaphoresis, etc – you do not need to fear using generous opiods for acute pain relief and home opiods if necessary. Since you will not addict these people, you do not need fear. You can quit writing people for Ultram and Flexeril. There are scenarios where the pain is purely subjective with no objective measures (eg headache, tooth pain, back pain, etc) – and these do require even more education, training and discretion – but these are often the minority of acute pain patients. So let’s get better educated about “addiction” and become very aggressive with acute pain management. OPERATIONS MANAGEMENT: “A novel approach to chronic pain patients” For decades, it has been the culture of emergency medicine to have a secret box, or bulletin board or back-room list or simply a word-of-mouth among nurses, docs and staff about “drug seekers”. And among patients who frequent the ER for chronic pain meds (eg headache, tooth pain, and back pain), they frequently know which doctors are “stern” (honest confronters? mean?) and which are “softer” (compassionate? enabler and afraid to confront?). Patients often come to the ER with their first question being “Who’s on tonight?” This type of culture is based mostly on secrecy and deception. We at Wesley ER want to take steps to begin to change this. We would like to chip away at the term “drugseeker” and ideally reduce it to a rare word in our vocabulary. We begin by identifying “special patients” that come to our ER frequently or for very unique needs. This would include unusual genetic diseases, hemophilia, sickle cell, migraine, etc as well as people with acute or chronic pain needs (which seem to center around back pain and tooth pain). For those “special patients” we create a fairly uniform care plan that may vary considerably from what we might do routinely as a medical professional. This “Special Patient Care Plan” (SPCP) splits patients into one of three categories: I. Patients who have objective evidence of illegal activity (eg altering a script) or bad behavior (hitting a nurse, leaving with an IV in, etc). These patients will receive only what is required by law: a medical screening exam. (cont’d on next page) Page 9 (cont’d from previous page) II. Patients who have subjective accusations of “drug seeking behavior”. These patients may or may not be offered “bridge” medications. They will be given a pamphlet for clinics and dental centers for the underserved as well as a pamphlet with regard to drug treatment centers. They will be asked to sign a 30 day “bridge” contract for chronic pain which gives them 30 days to find a primary care doctor. III. Patients with unusual medical conditions not centered around chronic pain issues with a patient specific plan of management. If our staff buys into this approach, it will be a major step forward in separating objective information from subjective assumption. It will also promote a uniform plan regardless of physician or nurse on duty. It may also provide us data to track and an approach with which we join hands with other local ERs. COST: “Price surprises” Generic Lortab 5.0 7.5 10 # 20/30 20/30 20/30 $ 12/12 12/20 12/20 Percocet 5.0 10 30 30 14 50 Dilaudid 4mg 20 14 Fentanyl patch 50 micrograms 4 100 Flexeril 10mg 20 10 Norflex 20 40 Oxycontin 40mg 30 221.41 Oramorph 30mgXR 30 40 * These are rough numbers and will vary substantially from pharmacy to pharmacy and even from year to year. It is interesting that it is roughly the same cost between 20 and 30 Lortab 5.0. Page 10 1. 2. AN ENDING THOUGHT: “Be a doctor, not a lawyer” Imagine you finished your career and you are standing before an audience made up of all the people you have ever treated for pain. Would you rather be known for being more accurate by catching more people that lied to you but you misjudged a fair number of people that suffered. Or would you rather be known for being overly compassionate by offering more people adequate pain control and hearing from a fair number of people that they fooled you? To me medicine is about advocacy and trust as compared to law which is adversarial and tries to find truth by distrust. Be a doctor, not a lawyer. If you are going to make any mistakes, let it be that you were too trusting and compassionate. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 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Moore PA et al. “Tramadol compared with… codeine and placebo” J Clin Pharm 1998 (June); 38(6): 554 19. Turturro MA et al. “Tramadol vs hydrocodone in acute musculoskeletal pain” Ann Emerg Med 1998 (Aug); 32(2): 139 20. Stubhaug A et al. “Lack of analgesic effect of oral Tramadol after orthopedic surgery” Pain July 1995; 62(1): 111 21. Li Wan et al. “Systemic overview of coproxamol…” Br Med J 1997 (Dec); 315(7122): 1565 22. Zhang WY et al. “Analgesic efficacy of paracetamol and its combination with codeine…” J Clin Pharm Ther 1996 (Aug); 21(4): 261 23. Tennant F. “Making Practical Sense of Cytochrome P450” Practical Pain Management May 2010: 12-18 24. American Pain Society recommendations (2003) 25. Spiegel et al. “Meperidine or morphine in acute pancreatitis” American Family Physician 2001; 64(2): 219 26. Charuluxan et al. “Nalbuphine versus Ondansetron for prevention of intrathecal morphine induced pruritis…” Anesthesia and Analgesia 2003; 96(6): 1789-93 27. Vessey W et al. “Informed consent in patients with acute abdominal pain” 1998; 85: 1278-80 28. Beilin Y et al. (no title listed) Anesth 2005; 103(6): 1211-17 (N=6) 29. Chang AK. “Safety and efficacy of rapid titration using 1mg doses of intravenous hydromorphone in ERs with acute severe pain (1 + 1 protocol)” Ann Emerg Med 2009; 54(2): 221-25 (N=223), Ann Emerg Med 48(2): 164-72 30. Wilhelm SM et al. “Prevention of postoperative nausea and vomiting” Ann of Pharmacotherapy 41(1): 68-78 31. DeLee JC et al. “Skeletal muscle spasm and a review of muscle relaxants” Curr Ther Res 1980; 27: 64-74 (review) 32. Pain Assessment and Pharmacological Management (2011) by Pasero and McCaffery. 693 33. Van Tulder et al. (2003) “Muscle relaxants for non-specific low back pain” Cochrane Database of systemic reviews (online) CD004252 34. Landerfield CS et al. “The Neurontin legacy – marketing through misinformation and manipulation” N Engl J Med 2009 (Jan 8): 360(2): 103-6 35. Our Daily Meds Melody Peterson (2008); Chapter seven: “Neurontin for everything” 212-52 Page 12 36. Wall Street Journal blog by Sarah Rubenstein “Hospital Chief of Acute Pain fabricated medical studies on Lyrica” March 12, 2009 37. Emergency Med Australasia 19(4); 315: August 2007 38. J Urol 2003; 170: 564-7 39. Witting M. “You wanna do what? Modern indications for nasogastric intubation” J Emerg Med 33(1); 2007: 61-64 40. Ann Emerg Med 50(4); 472: October 2007 41. Borland ML et al. “Comparative review of the clinical use of intranasal Fentanyl vs morphine in a pediatric emergency department” Emerg Med Australasia 2008 (Dec); 20(6): 515 42. Int Orthop 2002; 26(6): 361 43. William EV et al. “A prospective evaluation of ketofol in the emergency department” Ann Emerg Med January 2007; 49(1): 23-30 44. Bonomo J et al. “Inadequate provision of postintubation anxiolysis and analgesia in the ED” Am J Emerg Med 2008 (May); 26(4): 469 45. Baeyer C et al. “Children’s memory for pain” Journal of Pain 2004 (June); 6: 241-9 46. Schiller MJ et al. “Utility of routine drug screen in a psychiatric emergency department” Psychiatr Serv 51; 474-78: April 2000 47. Passik S et al. “Opiod therapy in patients with a history of substance abuse” CNS Drugs 2004; 18(1): 13-25 Opinions expressed are not necessarily those of Wesley or ESPA. Mention of products or services does not constitute endorsement. This publication is intended as a general guide and is intended to supplement, rather than substitute, professional judgment. It covers a highly technical and complex subject and should not be used for making specific medical decisions. The materials contained herein are not intended to establish policy, procedure, or standard of care. QUEAS-E CME September 2010 Name_______________________________________ *Wesley Medical Center is accredited by the Kansas Medical Society to sponsor continuing education for physicians. Date Completed_______________________________ 1. Toradol IM is superior to ibuprofen. Wesley designates this educational activity for a maximum 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim credit commensurate with the extent of their participation in the activities. T or F 2. The following decrease input into the reticular activating system (RAS): a. dimming the lights b. closing the door c. a warm blanket d. eye contact and a gentle touch e. all of the above 3. For patients over 70 years old in severe pain you should use: a. toradol only b. morphine 8mg IV c. Fentanyl 50 micrograms and 0.5mg hydromorphone IV d. Fentanyl 100 micrograms and 1mg hydromorphone IV e. Dilaudid 2mg IV and Phenergan 25mg IM 4. 20%-30% of the caucasian population metabolize morphine unreliably. T or F 5. Flexeril and valium are as effective as oxycodone for muscle spasm. T or F 6. It is unethical to paralyze a patient without sedation and analgesia. T or F 7. Urine drug tests are accurate at picking up Lortab. T or F 8. All foleys in children and adults should be placed with viscous lidocaine in the ER. T or F Circle the one correct answer. To complete this educational activity, please check your test for accuracy. The correct answers can be found on the evaluation. Dr. Mosley has disclosed that he does not have any financial relationship with any product or equipment that he writes about. (Evaluation following) Page 13 Continuing Medical Education QUEAS-E Update Evaluation Please circle a response to the following: 1. Having read this CME activity, the participant should be better able to: demonstrate an increased awareness of current practices, new therapies and new technologies appropriate for patients in the Emergency Department? Agree 2. 4. 4 3 2 1 Disagree The educational content in this CME article will be: Very useful 3. 5 5 4 3 2 1 Not at all useful A great deal 5 4 3 2 1 In this article I learned: Little As a result of this CME article do you anticipate making a change in your practice? Yes [ ] 5. Additional comments: 6. What topics would you suggest for future articles? (Answers to post test: 1. F 2. e 3. c 4. F No [ 5. F ] 6.T 7. F 8. T) For CME credit, please mail this sheet to: Wesley CME Dept., 550 N. Hillside, Wichita, KS 67214 Please note: This publication is designed for physicians and documentation of CME will be provided to physicians on an annual basis. For a transcript of credit for a specific timeframe, please contact the Wesley CME Department @ 316-962-3304 or [email protected] Credit Statement KMS Accreditation Statement Wesley Medical Center is accredited by the Kansas Medical Society to sponsor continuing education for physicians. Wesley designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)TM. Physicians should claim credit commensurate with the extent of their participation in the activities. L:/Jeri/WEmergency/Issue#88newsletterSept2010forwebsite.doc Page 14