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THE KNEE SOCIETY The 2016 Specialty Day Meeting of The Knee Society In association with the American Association of Hip and Knee Surgeons (AAHKS) Final Scientific Program Saturday, March 5, 2016 Orange County Convention Center, West Bldg., Valencia Room B Orlando, Florida ANNOUNCEMENTS AAOS Annual Meetings March 14-18, 2017 San Diego, California March 6-10, 2018 New Orleans, Louisiana AAHKS 26th Annual Meeting Save the Date - New Location! November 10-13, 2016 Hilton Anatole, Dallas, Texas AAHKS 26th Annual Meeting Call for Symposia Submit proposals by May 2, 2016 covering all aspects of arthroplasty and health policy. AAHKS 26th Annual Meeting Call for Abstracts Submit abstracts by June 1, 2016 for consideration as podium or poster presentations. Submit symposia and abstracts online at www.AAHKS.org. AAHKS 27th Annual Meeting November 2-5, 2017 Hilton Anatole, Dallas, Texas Digital Archives Are Yours For 1 Year! On-site participants of the 2016 Specialty Day Meeting of The Knee Society and AAHKS will receive complimentary access to video archives for one year beginning April 15, 2016. This program is streaming LIVE via the Internet to participants around the world. Live-streaming and recording services are provided by: © 2016 The Knee Society 2 WELCOME TO THE 2016 SPECIALTY DAY MEETING OF THE KNEE SOCIETY AND AAHKS GENERAL INFORMATION The Mission of The Knee Society: The mission of The Knee Society is to promote outstanding care to patients with knee disorders through innovative research and education. Meeting Objectives: The Knee Society/AAHKS Specialty Day Meeting is designed to update clinical skills and basic knowledge through research findings and biomechanical studies; to discuss the various surgical and non-surgical treatments and management of conditions related to the knee joint; to determine indications and complications in total knee arthroplasty; to critique presentations of surgical techniques and demonstrations of treatment options; and to evaluate the efficacy of new treatment options through evidence-based data. CME Accreditation: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the American Academy of Orthopaedic Surgeons and the Knee Society. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians. The American Academy of Orthopaedic Surgeons designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. IMPORTANT Please complete evaluation online at: https://www.surveymonkey.com/r/KSSD16 or use the QR code to access. Please silence all electronic devices while inside the session room. Please refrain from unauthorized photography and video recording of presentations. Your registration for, and attendance of, this session gives The Knee Society permission to capture images of session attendees and to use these images for internal and marketing purposes. © 2016 The Knee Society 3 ACKNOWLEDGMENTS PAST PRESIDENTS OF THE KNEE SOCIETY PAST PRESIDENTS OF AAHKS 1983 Chitranjan S. Ranawat, MD 1991 J. Phillip Nelson, MD 1984 Chitranjan S. Ranawat, MD 1992-1993 Chitranjan S. Ranawat, MD 1985 Richard S. Bryan, MD (Deceased) 1994 Richard C. Johnston, MD, MS 1986 John N. Insall, MD (Deceased) 1995 Lawrence D. Dorr, MD 1987 Charles O. Townley, MD (Deceased) 1996 Hugh S. Tullos, MD (Deceased) 1988 David G. Murray, MD 1997 Merrill A. Ritter, MD 1989 Frederick C. Ewald, MD 1998 Richard H. Rothman, MD, PhD 1990 Lawrence D. Dorr, MD 1999 James A. Rand, MD 1991 Herbert Kaufer, MD 2000 Richard B. Welch, MD 1992 Paul A. Lotke, MD 2001 John J. Callaghan, MD 1993 Leonard Marmor, MD (Deceased) 2002 Douglas A. Dennis, MD 1994 David S. Hungerford, MD 2003 Clifford W. Colwell, Jr., MD 1995 Richard D. Scott, MD 2004 Richard F. Santore, MD 1996 Victor M. Goldberg, MD (Deceased) 2005 Joseph C. McCarthy, MD 1997 W. Norman Scott, MD 2006 William J. Hozack, MD 1998 James A. Rand, MD 2007 Daniel J. Berry, MD 1999 Kenneth A. Krackow, MD 2008 David G. Lewallen, MD 2000 Thomas S. Thornhill, MD 2009 William J. Robb, III, MD 2001 Clifford W. Colwell, Jr., MD 2010 Mary I. O’Connor, MD 2002 Robert E. Booth, Jr., MD 2011 Carlos J. Lavernia, MD 2003 Cecil H. Rorabeck, MD 2012 Thomas P. Vail, MD 2004 Merrill A. Ritter, MD 2013 Thomas K. Fehring, MD 2005 Russell E. Windsor, MD 2014 Brian S. Parsley, MD 2006 Gerard A. Engh, MD 2007 Michael A. Kelly, MD 2008 Douglas A. Dennis, MD 2009 William L. Healy, MD 2010 Arlen D. Hanssen, MD 2011 Robert B. Bourne, MD, FRCSC 2012 Giles R. Scuderi, MD 2013 Steven J. MacDonald, MD, FRCSC 2014 Thomas K. Fehring, MD © 2016 The Knee Society 4 ACKNOWLEDGMENTS THE KNEE SOCIETY EXECUTIVE BOARD 2015-2016 AAHKS BOARD OF DIRECTORS 2015-2016 Thomas P. Vail, MD – President Jay R. Lieberman, MD - President Thomas P. Sculco, MD – 1st Vice President William A. Jiranek, MD - 1st Vice President Adolph V. Lombardi, Jr., MD – Robert L. Barrack, MD – 3rd 2nd Vice President David A. Halsey, MD - 2nd Vice President Vice President Mark I. Froimson, MD - 3rd Vice President Thomas K. Fehring, MD – Immediate Past President Brian S. Parsley, MD - Immediate Past President Steven J. MacDonald, MD – Past President Michael P. Bolognesi, MD - Secretary Michael E. Berend, MD – Secretary, Chair, Tech. Cmte. C. Lowry Barnes, MD - Treasurer Mark W. Pagnano, MD – Treasurer Joseph T. Moskal, MD – Member-at-Large Mark P. Figgie, MD – Chair, Membership Committee Ryan M. Nunley, MD – Member–at - Large Christopher L. Peters, MD – Chair-Elect, Membership Cmte. Audrey K. Tsao, MD – Member-at-Large Kevin J. Bozic, MD, MBA – Chair, Education Committee Bryan D. Springer, MD – Chair, Research Committee AAHKS EDUCATION AND COMMUNICATIONS COUNCIL Fred D. Cushner, MD – Member-At-Large Craig J. Della Valle, MD – Member-At-Large Craig J. Della Valle, MD -- Chair Bryan D. Springer, MD – Vice Chair Stephen J. Incavo, MD – Chair-Elect, Education Committee John C. Clohisy, MD THE KNEE SOCIETY EDUCATION COMMITTEE 2015-2016 Gregory G. Polkowski, II, MD Kevin J. Bozic, MD, MBA – Chair Keith R. Berend, MD Stephen J. Incavo, MD – Chair-Elect David F. Dalury, MD Keith R. Berend, MD William P. Barrett, MD R. Michael Meneghini, MD William A. Jiranek, MD Jeffrey A. Geller, MD Timothy M. Wright, PhD AAHKS EDUCATION COMMITTEE 2015-2016 William L. Griffin, MD – Past Chair William P. Barrett, MD - Chair Michael R. O’Rourke, MD Douglas E. Padgett, MD Gregory J. Golladay, MD Jay J. Patel, MD David A. Halsey, MD © 2016 The Knee Society 5 THE 2016 KNEE SOCIETY SCIENTIFIC AWARDS The Scientific Awards will be presented from 1:01 pm – 1:33 pm In October 1993, The Knee Society’s Executive Board established an award program to recognize meritorious presentations at the annual Specialty Day meetings. The Board designated three awards to be presented annually, in honor of The Knee Society members: Mark Coventry, MD, Chitranjan S. Ranawat, MD, and John N. Insall, MD. This year’s award recipients are: The John N. Insall, MD, Award Do Injections Increase the Risk of Infection Following TKA? Presenter: Nicholas A. Bedard, MD Co-Authors: Andrew J. Pugely, MD; Jacob M. Elkins, MD, PhD; Kyle R. Duchman, MD; Robert W. Westermann, MD; Steve S. Liu, MD; Yubo Gao, PhD; John J. Callaghan, MD The Chitranjan S. Ranawat, MD, Award No Difference in Two-Year Functional Outcomes Using Kinematic Versus Mechanical Alignment in TKA Presenter: Simon W. Young, FRACS Co-Authors: Matthew L. Walker, FRACS; Ali Bayan, FRACS; Toby Briant-Evans, FRCS; Paul Pavlou, FRCS; Bill Farrington, FRCS, FRACS The Mark Coventry, MD, Award Oral Antibiotics Reduce Reinfection Following 2-Stage Exchange: A Multi-Center, Randomized Controlled Trial Presenter: Craig J. Della Valle, MD Co-Authors: Jonathan M. Frank, MD; Erdan Kayupov, MSE; Mario Moric, MA; John Segreti, MD; Erik Hansen, MD; Curtis Hartman, MD; Kamil Okroj Congratulations to presenting authors and their co-authors! The Knee Society Scientific Awards Manuscripts in consideration for the 2017 Knee Society Scientific Awards may be submitted beginning in September 2016 through Clinical Orthopaedic and Related Research (CORR). The deadline to submit is December 1, 2016. © 2016 The Knee Society 6 THE 2016 YOUNG INVESTIGATOR SYMPOSIUM The Young Investigator Symposium will be presented from 4:06 pm – 4:35 pm Closed Incision Negative Pressure Therapy Versus Antimicrobial Dressings Following Revision Hip and Knee Surgery: A Comparative Study Presenter: H. John Cooper, MD Co-Author: Marcel A. Bas, MD Discharge Destination after Total Knee Arthroplasty: An Analysis of Post-Discharge Outcomes and Risk Factors Presenter: Calin S. Moucha, MD Co-Author: Aakash Keswani Thrombogenic Risk of Unicompartmental Knee Versus Total Knee Replacement Presenter: Edwin P. Su, MD Co-Authors: Lauren E. Mount, MD; Allina Nocon, MPH; Thomas P. Sculco, MD; George Go, BS; Nigel E. Sharrock, BMedSci, MB, ChB IN THIS BOOK PAGE 16 Detailed Schedule Abstracts 27 Disclosures 80 The Hip Society’s Program © 2016 The Knee Society On reverse side 7 THE KNEE SOCIETY’S RESEARCH & EDUCATION FUND The Knee Society thanks the following donors to the Fund for their generosity Mentor Level ($250,000 - $499,999) Leadership Level ($2,500-$9,999) Dr. & Mrs. Adolph V. Lombardi, Jr.* Zimmer Biomet, Inc.* Stephanie & Chad Alvarez* David Eichler* Derek Fox & Aaron Gatten / Apex Surgical* Leo Fusilli* Dan Kelley* Joey Matt* Jason Olejniczak / Midwest Biomet* Rick Page & Marc Vreede / Biomet Detroit* Brett Parkin / Biomet West, Inc.* Lance & Lisa Perry* Jim Reiff / Northwest Biomet* Steven L. Rohlf* Mike & Lori Schmitt* Stallings Orthopedics, Inc.* Thomas P. Vail, MD John White / Biomet Corp.* David Whitman & David Burke/Select Orthopedics* Dan Williamson* Shane Zeringue* Partner Level ($100,000 - $249,999) Biomet, Inc.* Dr. & Mrs. Keith R. Berend* Michael E. Berend, MD* Chitranjan S. Ranawat, MD Advisor Level ($25,000 - $99,999) Mason Jones* Jeffrey R. McLaughlin, MD* Visionary Level ($10,000 - $24,999) Loyalty Level ($500 - $2,499) Gary Barnett* Biomet MidOhio, Inc.* Case Medical, Inc. * Craig J. Della Valle, MD* Christopher Dodd, MD* Jeff Grover / Greater Michigan Biomet* Jeff Hibbard / Biomet-Hibbard* David W. Murray, MD* Patrick Riccione* Timothy E. Green* William L. Griffin, MD Matt Harper / Biomet So. Texas* William L. Healy, MD Brian & Jennifer May* John Merageas* * Contribution given in memory of Dane A. Miller, PhD The Knee Society is a tax-exempt 501(c)(3) organization. Donations made to the The Knee Society may be tax-deductible to the extent permitted by law. © 2016 The Knee Society 8 © 2016 The Knee Society 9 © 2016 The Knee Society 10 CONGRATULATIONS TO THE 2016 JOHN N. INSALL TRAVELLING FELLOWS Davide E. Bonasia, MD AO Mauriziano Hospital University of Torino Torino, Italy Michael J. Taunton, MD Mayo Clinic Dept. of Orthopedic Surgery Rochester, Minnesota Jonathan Vigdorchik, MD NYU Langone/Hospital for Joint Disease Dept. of Orthopedic Surgery New York, New York Chun Hoi Yan, MD University of Hong Kong Queen Mary Hospital Dept. of Orthopedics & Traumatology Hong Kong Visit The Knee Society website at www.kneesociety.org for more information and to download the application. © 2016 The Knee Society 11 © 2016 The Knee Society 12 © 2016 The Knee Society 13 © 2016 The Knee Society 14 PROGRAM © 2016 The Knee Society 15 KNEE Valencia Room B Page 8:00 am – 8:02 am WELCOME Thomas P. Vail, MD (San Francisco, CA) President, The Knee Society 8:02 am – 8:04 am Kevin J. Bozic, MD, MBA (Austin, TX) Chair, Education Committee, The Knee Society 8:05 am – 8:52 am Session I: Minimizing TKA Complications Moderator: John J. Callaghan, MD (Iowa City, IA) 8:05 am – 8:12 am 27 Periprosthetic Joint Infection: Controversies and Areas in Need of Research Javad Parvizi, MD (Philadelphia, PA) 8:13 am – 8:20 am 28 Prevention and Management of Instability in TKA Thomas K. Fehring (Charlotte, NC) 8:21 am – 8:28 am 30 Optimizing Risk Factors Richard Iorio (New Rochelle, NY) 8:29 am – 8:36 am 33 Venous Thromboembolism Jay R. Lieberman, MD (Los Angeles, CA) 8:37 am – 8:52 am DISCUSSION 8:53 am – 10:04 am Session II: TKA Alignment: Mechanical, Anatomic, or Kinematic Moderator: Thomas P. Schmalzried, MD (Los Angeles, CA) 8:53 am – 9:00 am 34 Mechanical Alignment Douglas A. Dennis (Denver, CO) 9:01 am – 9:08 am 35 Anatomic Alignment Michael A. Mont, MD (Baltimore, MD) 9:09 am – 9:16 am 36 Kinematic Alignment Stephen M. Howell, MD (Sacramento, CA) 9:17 am – 9:24 am 38 Custom Cutting Guides Adolph V. Lombardi, Jr., MD, FACS (New Albany, OH) 9:25 am – 9:32 am 39 Robotics for UKA and Potential Role in TKA Jess H. Lonner, MD (Bryn Mawr, PA) 9:33 am – 9:40 am 41 Computer Navigation: Past, Present, Future S. David Stulberg, MD (Chicago, IL) 9:41 am – 9:48 am 43 Mechanical Guides Robert E. Booth, MD (Philadelphia, PA) © 2016 The Knee Society 16 Valencia Room A Page HIP 8:00 am – 8:04 am WELCOME Daniel J. Berry, MD (Rochester, MN) President of The Hip Society 8:05 am – 8:49 am Session I: Direct Anterior THA: Controversies, Data, Techniques in 2016 Moderator: Steven J. MacDonald, MD, FRCSC (London, ON, Canada) 8:05 am – 8:10 am 26 Perspective of a Convert: Why I Changed to Direct Anterior Approach and the Associated Learning Curve Adolph V. Lombardi, Jr., MD, FACS (New Albany, OH) 8:11 am – 8:16 am 28 The Direct Anterior Approach in a Risk Factor for Early Failure in Cementless Total Hip Arthroplasty: A Multi-Center Study R. Michael Meneghini, MD (Fishers, IN) 8:17 am – 8:22 am 29 Surgical Tips and Pearls to Maximize Success of Direct Anterior THA Done with an Orthopedic Table Joel M. Matta, MD (Santa Monica, CA) 8:23 am – 8:28 am 31 Surgical Tips and Pearls to Maximize Success of Direct Anterior THA Done without a Fracture Table William J. Hozack, MD (Philadelphia, PA) 8:29 am – 8:34 am 33 The Accumulated Evidence Supports Posterior Approach THA as the Gold Standard in 2016 Bryan D. Springer, MD (Charlotte, NC) 8:34 am – 8:49 am Discussion 8:50 am – 9:40 am Session II: Contemporary Insights into Unsolved Problems in THA Moderator: Clive P. Duncan, MD, FRCSC (Vancouver, BC, Canada) 8:50 am – 8:55 am 35 Abductor Deficiency and THA: Diagnosis and Management Richard W. McCalden, MD, FRCSC (London, ON, Canada) 8:56 am – 9:01 am 36 Psoas Impingement & Tendinopathies after THA: Diagnosis and Management William A. Jiranek, MD (Richmond, VA) 9:02 am – 9:07 am 38 THA for the Patient with a BMI over 40: Risk and Reward David G. Lewallen, MD (Rochester, MN) 9:08 am – 9:13 am 40 Recurrent Dislocation in the Patient with a Constrained Liner or Dual-Mobility Implant: What Now? John J. Callaghan, MD (Iowa City, IA) © 2016 The Knee Society 17 KNEE Valencia Room B Page 9:49 am – 10:04 am DISCUSSION 10:05 am – 10:15 am BREAK 10:16 am – 11:03 am Session III: The Painful TKA: Prevention, Evaluation, and Management Moderator: Aaron G. Rosenberg, MD, FACS (Chicago, IL) 10:16 am – 10:23 am 45 Managing Expectations Michael J. Dunbar, MD, FRCSC, PhD (Halifax, NS, Canada) 10:24 am – 10:31 am 47 Optimizing Emotional Health David C. Ayers, MD (Worcester, MA) 10:32 am – 10:39 am 48 Pre- and Post-Operative Opioid Management Thomas P. Vail, MD (San Francisco, CA) 10:40 am – 10:47 am 49 The Role of “Pain Management” Craig J. Della Valle, MD (Chicago, IL) 10:48 am – 11:03 am DISCUSSION 11:04 am – 12:00 pm Session IV: Transitioning to Value-Based Healthcare Moderator: Kevin J. Bozic, MD, MBA (Austin, TX) 11:04 am – 11:11 am 50 Bundled Payments and Other Value-Based Payment Strategies Kevin J. Bozic, MD, MBA (Austin, TX) 11:12 am – 11:19 am 51 The Role of the EMR in Improving Value Wael K. Barsoum, MD (Cleveland, OH) 11:20 am – 11:27 am 53 The Role of Registries in Improving Value Colin Howie, ChB, FRCS, FRCS (Ortho) (Edinburgh, United Kingdom) 11:28 am – 11:35 am 54 Integrated Delivery Systems are Key to Value Creation Mark I. Froimson, MD (Hunting Valley, OH) 11:36 am – 11:43 am 56 Private Practice Models are More Nimble Daniel B. Murrey, MD, MPP (Charlotte, NC) 11:44 am – 12:00 pm DISCUSSION 12:00 pm – 1:00 pm LUNCH © 2016 The Knee Society 18 Valencia Room A Page HIP 9:14 am – 9:19 am 41 Pelvic Discontinuity: Newest Knowledge and Technical Tips in Management Wayne G. Paprosky, MD, FACS (Winfield, IL) 9:20 am – 9:25 am 42 Failed 2-Stage THR Arlen D. Hanssen, MD (Rochester, MN) 9:25 am – 9:40 am DISCUSSION 9:40 am – 9:55 am BREAK 9:56 am – 10:34 am Session III: Strategies to Speed Recovery and Decrease Complications after THA Moderator: Mark W. Pagnano, MD (Rochester, MN) 9:56 am – 10:01 am 43 Perioperative Management: Get Ahead and Stay Ahead Mark W. Pagnano, MD (Rochester, MN) 10:02 am – 10:07 am 44 Role of Staphylococcal Screening and Treatment Prior to THA Scott M. Sporer, MD (Winfield, IL) 10:08 am – 10:13 am 46 Risk Stratified VTE Prophylaxis after THA Jay R. Lieberman, MD (Los Angeles, CA) 10:14 am – 10:19 am 47 Outpatient Joint Replacement Michael E. Berend, MD (Indianapolis, IN) 10:19 am – 10:34 am DISCUSSION 10:35 am – 11:10 am Session IV: Complex Primary THA: Case-Based Discussion on the State of the Art Moderator: Daniel J. Berry, MD (Rochester, MN) 10:35 am – 10:55 am Panel: Richard Iorio, MD (New Rochelle, NY); Michael E. Berend, MD (Indianapolis, IN); Greg G. Polkowski, II, MD (Nashville, TN); Prof. Fares S. Haddad, FRCS (London, United Kingdom); Miguel E. Cabanela, MD (Rochester, MN) 10:55 pm – 11:10 am DISCUSSION 11:11 am – 11:33 am Session V: Taper Corrosion in Orthopaedic Devices – Newest Knowledge Moderator: Joshua J. Jacobs, MD (Chicago, IL) 11:11 am – 11:16 am 48 Dual Modular Necks in THA: How Big is the Problem? What Caused the Problem? What Have we Learned? Michael A. Mont, MD (Baltimore, MD) 11:17 am – 11:22 am 49 When to Revise and What to Revise if Trunionosis is Suspected? Joshua J. Jacobs, MD (Chicago, IL) 11:23 pm – 11:33 am © 2016 The Knee Society DISCUSSION 19 KNEE Valencia Room B Page 1:01 PM – 1:33 PM Session Va: The Knee Society’s Scientific Awards Moderator: Lawrence D. Dorr, MD (Los Angeles, CA) 1:01 pm – 1:11 pm 57 The John N. Insall, MD Award “Do Injections Increase the Risk of Infection Following TKA?”: Presenter: Nicholas Bedard, MD (Iowa City, IA) 1:12 pm – 1:22 pm 58 The Chitranjan S. Ranawat, MD Award “No Difference in Two-Year Functional Outcomes Using Kinematic Versus Mechanical Alignment in TKA” Presenter: Simon W. Young, FRACS (Auckland, New Zealand) 1:23 pm – 1:33 pm 59 The Mark Coventry, MD Award “Oral Antibiotics Reduce Reinfection Following 2-Stage Exchange: A Multi-Center, Randomized Controlled Trial” Presenter: Craig J. Della Valle, MD (Chicago, IL) 1:34 pm – 1:45 pm Session Vb: Highlights 1:34 pm – 1:39 pm AAHKS 2015 Annual Meeting Gregory G. Polkowski, II, MD (Nashville, TN) 1:40 pm – 1:45 pm The John N. Insall, MD Traveling Fellowship W. Norman Scott, MD (New York, NY) 1:46 pm – 2:31 pm Session VI: Peri-Operative Management—How Do I Do It? Moderator: Daniel J. Berry, MD (Rochester, MN) Prof. Fares S. Haddad, BSc MD (Res) FRCS (Orth) (London, United Kingdom); Steven J. MacDonald, MD, FRCSC (London, ON, Canada); R. Michael Meneghini, MD (Fishers, IN); Michael P. Bolognesi, MD, MS (Durham, NC); C. Lowry Barnes, MD (Little Rock, AK); Mark W. Pagnano, MD (Rochester, MN) 2:31 pm – 2:50 pm BREAK 2:51 pm – 4:05 pm Session VII: Case Presentations Moderator: Thomas P. Vail, MD (San Francisco, CA) 2:51 pm – 2:58 pm 60 When is TKA Appropriate? Ryan M. Nunley, MD (St. Louis, MO) 2:59 pm – 3:06 pm 61 When Enough is Enough? Michael Ries, MD (Carson City, NV) 3:07 pm – 3:14 pm 62 Peri-Prosthetic Fractures – What to Do? Bassam A. Masri, MD, FRCSC (Vancouver, BC, Canada) © 2016 The Knee Society 20 Valencia Room A Page 11:34 am – 11:50 am 50 HIP Program Highlight: Presidential Guest Speaker Introduction: Daniel J. Berry, MD (Rochester, MN) Taper Corrosion in THA: What Causes it and Why are We Seeing it Now? Michael M. Morlock, PhD (Hamburg, Germany) 11:54 am – 12:50 pm LUNCH 12:50 pm – 1:28 pm Session VI: Top 3 New and Impactful Findings from Joint Registries Around the Globe Moderator: Kevin J. Bozic, MD, MBA (Austin, TX) 12:50 pm – 12:55 pm 52 Top Findings from Australian National Joint Registry Richard N. de Steiger, MD (Richmond, Australia) 12:56 pm – 1:01 pm 54 Top Findings from British National Joint Registry Martyn Porter, MD (Wigan, United Kingdom) 1:02 pm – 1:07 pm 55 Top Findings from Scandinavian Joint Registries Henrik Malchau, MD, PhD (Boston, MA) 1:08 pm – 1:13 pm 56 American Joint Replacement Registry: High Level Update Kevin J. Bozic, MD, MBA (Austin, TX) 1:13 pm – 1:28 pm DISCUSSION 1:29 pm – 2:19 pm Session VII: Is Cross-Linked Poly Now the Bearing of Choice? Moderator: William J. Maloney, III, MD (Redwood City, CA) 1:29 pm – 1:34 pm 58 Results of Cross-Linked Poly at 10 Years or More Harry E. Rubash, MD (Boston, MA) 1:35 pm – 1:40 pm 59 Highly Cross-Linked Polyethylene Provides Decreased Osteolysis and Reoperation Paul F. Lachiewicz, MD (Chapel Hill, NC) 1:41 pm – 1:46 pm 60 Ceramic vs. Metal Femoral Heads: What is the Role for Each in 2016? Thomas P. Schmalzried, MD (Los Angeles, CA) 1:47 pm – 1:52 pm 62 Ceramic-on-Ceramic Bearings in 2016: A Perspective from Outside the United States Carsten Perka, MD (Berlin, Germany) 1:53 pm – 1:58 pm 63 Dual Mobility Implants: What is Their Role in Primary THA? Jean-Noël Argenson, MD (Marseille, France) 1:59 pm – 2:04 pm 66 Failed Metal-on-Metal Current Diagnostic Algorithms and Guidellines Thomas K. Fehring, MD (Charlotte, NC) © 2016 The Knee Society 21 KNEE Valencia Room B Page 3:15 pm – 3:22 pm 65 Dealing with Extensor Mechanism Deficiency Matthew S. Austin, MD (Philadelphia, PA) 3:23 pm – 3:30 pm 67 Treatment of the Unstable TKA Robert T. Trousdale, MD (Rochester, MN) 3:31 pm – 3:38 pm 68 Is This Knee Infected? Kevin L. Garvin, MD (Omaha, NE) 3:39 pm – 3:46 pm 71 Patient is Unhappy, but I Don’t Know Why Robert L. Barrack, MD (St. Louis, MO) 3:46 pm – 4:05 pm DISCUSSION 4:06 pm – 4:35 pm Session VIII: Young Investigator Symposium Moderator: Mary I. O’Connor, MD (New Haven, CT) 4:07 pm – 4:12 pm 72 Paper I “Closed Incision Negative Pressure Therapy Versus Antimicrobial Dressings Following Revision Hip and Knee Surgery: A Comparative Study” H. John Cooper, MD (New York, NY) 4:13 pm – 4:18 pm 73 Paper 2 “Discharge Destination after Total Knee Arthroplasty: An Analysis of Post-Discharge Outcomes and Risk Factors” Calin S. Moucha, MD (New York, NY) 4:19 pm – 4:24 pm 75 Paper 3 “Thrombogenic Risk of Unicompartmental Knee versus Total Knee Replacement” Edwin Philip Su, MD (New York, NY) 4:25 pm – 4:35 pm DISCUSSION 4:36 pm – 5:00 pm Session IX: Transitioning to Outpatient TKA Moderator: Michael E. Berend, MD (Indianapolis, IN) 4:36 pm – 4:43 pm 77 Building an Outpatient TKA Program Keith R. Berend, MD (New Albany, OH) 4:44 pm – 4:51 pm 78 Outpatient TKA is a Triumph of Knowledge over Reason Bryan D. Springer, MD (Charlotte, NC) 4:51 pm – 5:00 pm DISCUSSION 5:00 pm ADJOURN © 2016 The Knee Society 22 Valencia Room A Page HIP 2:04 pm – 2:19 pm DISCUSSION 2:20 pm – 2:52 pm Session VIII: How Do We Ideally Position the Acetabular Component? Moderator: Robert T. Trousdale, MD (Rochester, MN) 2:20 pm – 2:25 pm 69 Newest Knowledge on Ideal Component Position Lawrence D. Dorr, MD (Pasadena, CA) 2:26 pm – 2:31 pm 71 The Impact of Lumbar Spine Pathology on Functional Hip Position Douglas E. Padgett, MD (New York, NY) 2:32 pm – 2:37 pm 72 Socket Position and the Risk of Dislocation after Revision THA Robert L. Barrack, MD (St. Louis, MO) 2:37 pm – 2:52 pm DISCUSSION 2:53 pm – 2:57 pm 6 2:58 pm – 3:15 pm Program Highlight: The Hip Society’s 2016 Lifetime Achievement Award Introduction: Daniel J. Berry, MD (Rochester, MN) Recipient: Clive P. Duncan, MD, FRCSC (Vancouver, BC, Canada) Session IX: The Hip Society Scientific Awards Moderators: Thomas P. Vail, MD (San Francisco, CA) A. Seth Greenwald, D.Phil (Oxon) (Cleveland, OH) 2:58 pm – 3:03pm 74 The John Charnley Award The Missing Link: Re-Defining the Natural Progression of Osteoarthritis in Patients with Hip Dysplasia and Impingement Rafael J. Sierra, MD (Rochester, MN) 3:04 pm – 3:09 pm 76 The Otto AuFranc Award A Multi-Center, Prospective, Randomized Study of Outpatient Versus Inpatient Total Hip Arthroplasty Nitin Goyal, MD (Alexandria, VA) 3:10 pm – 3:15 pm 78 The Frank Stinchfield Award Total Hip Arthroplasty For Femoral Neck Fracture Is Not A Typical DRG 470: A Propensity-Matched Cohort Study Alexander S. McLawhorn, MD, MBA (New York, NY) 3:16 pm – 3:26 pm BREAK 3:27 pm – 4:15 pm Session X: Revision THA Video Technical Tips to Improve Results Moderator: C. Anderson Engh, MD (Alexandria, VA) 3:27 pm – 3:32 pm 80 © 2016 The Knee Society Revision THA for Periprosthetic Fracture George J. Haidukewych, MD (Orlando, FL) 23 © 2016 The Knee Society 24 Valencia Room A Page 3:33 pm – 3:38 pm 81 Extended Trochanteric Osteomy Tips and Tricks Craig J. Della Valle, MD (Chicago, IL) 3:39 pm – 3:44 pm 82 Fluted Tapered Stems in Revision THA Scott M. Sporer, MD (Winfield, IL) 3:45 pm – 3:50 pm 84 Custom Triflange Cup: Planning and Execution Douglas A. Dennis, MD (Denver, CO) 3:51 pm – 3:56 pm 86 The Cup-Cage Construct Allen E. Gross, MD, FRCSC (Toronto, ON, Canada) 3:57 pm – 4:02 pm 89 High-Dose Antibiotic Containing Spacers for Infected THA Kevin L. Garvin, MD (Omaha, NE) 4:02 pm – 4:15 pm DISCUSSION 4:16 pm – 4:23 pm Session XIa: Young Investigator Presentation Timothy M. Wright, PhD (New York, NY) 4:16 pm – 4:21pm 92 HIP Removal of an Infected Hip Arthroplasty is High-Risk Surgery: Putting Morbidity into Context with other Major Non-Orthopaedic Operations James A. Browne, MD (Charlottsville, VA) 4:21 pm – 4:23 pm DISCUSSION 4:24 pm – 4:32 pm Session Xlb: The Hip Society Rothman-Ranawat Traveling Fellowship Moderator: Chitranjan S. Ranawat, MD (New York, NY) 4:24 pm – 4:29 pm Highlights of the 2015 Experience Brian M. Curtin, MD (Charlotte, NC) and Eoin C. Sheehan, MD (Tullamore, Ireland) 4:30 pm – 4:32 pm Introduction of the 2016 Hip Society Rothman-Ranawat Traveling Fellows Chitranjan S. Ranawat, MD (New York, NY) 4:33 pm – 5:10 pm Session XII: Impingement and Dysplasia Moderator: Michael B. Millis, MD (Boston, MA) 4:33 pm – 4:38 pm 93 Complications after Hip Arthroscopy: A Prospective Multicenter Trial Utilizing a Validated Grading Scheme Christopher M. Larson, MD (Edina, MN) 4:39 pm – 4:44 pm 94 Risks for Conversion to THA after Primary Hip Arthroscopy in a Healthcare System Christopher L. Peters, MD (Salt Lake City, UT) © 2016 The Knee Society 25 HIP Valencia Room A Page 4:45 pm – 4:50 pm 97 Average 10-Year Clinical Outcomes of the Bernese PAO for the Treatment of Classic Acetabular Dysplasia John C. Clohisy, MD (St. Louis, MO) 4:51 pm – 4:56 pm 99 Predictors of Success for Joint Preserving Surgery of the Hip Paul E. Beaulé, MD, FRCSC (Ottawa, ON, Canada) 4:57 pm – 5:10 pm Discussion 5:10 pm ADJOURN © 2016 The Knee Society 26 ABSTRACTS AND MEETING MATERIALS Session I: Minimizing TKA Complications 8:05 am – 8:12 am Preventing Periprosthetic Joint Infection: Strategies that Work Javad Parvizi, MD Periprosthetic joint infection (PJI) is becoming the leading cause of failure following total joint arthroplasty (TJA) and several studies have identified independent risk factors for the development of PJI. Despite the debates revolving around some of the identified risk factors, several preventative perioperative strategies are currently commonly in use. Detailed evaluation of our institutional data and published reports have been performed to identify perioperative strategies that can be used to minimize the risk of developing a PJI. Strong evidence was found to support preoperative health and nutritional status optimization, the use of prophylactic antibiotics and antibiotic impregnated cement, preoperative skin preparation and the use of disposable draping, shorter operative time, cautious use of anticoagulants and the avoidance of allogeneic blood transfusion. Little or no evidence was found to support the use of laminar flow operating rooms or use of personalized protection suit, double gloving, hair removal, changing blades after skin incision, or addition of antibiotic to the irrigation solution. Many of the commonly used practices to lower PJI lack strong data to support their use highlighting the need for larger randomized controlled studies. There is, on the other hand, strong support for implementation of simple strategies that could minimize risk of PJI. © 2016 The Knee Society 27 8:13 am – 8:20 am Prevention and Treatment of Knee Instability Thomas K. Fehring, MD OrthoCarolina Hip and Knee Center Introduction Early failure of TKA is discouraging to patient and surgeon alike. Prosthetic knee instability has been shown to be the leading cause of reoperation in a series of knees revised within the first five years (2). Symptoms Gross collateral instability is easily diagnosed, however most instability patterns are subtle requiring a careful history and physical. Symptoms include catching, giving way, anterior knee pain, pain over the pes bursa, or a feeling that the knee can’t be trusted especially descending stairs (1). Recurrent effusions due to chronic micromotion with a predominance of red blood cells on aspirate can be helpful in making the diagnosis (3). Classification The OrthoCarolina Knee Instability Classification System can be helpful to guide diagnosis and treatment. Symptoms Subtle-giving way, lack of trust, anterior knee pain Type 1A Coronal instability with competent collateral ligaments Type 1B Coronal instability with incompetent collateral ligaments Gross instability, difficulty ambulating Type 2 Flexion and extension gap mismatch Can be subtle or severe, giving way, catching, lack of trust, anterior knee pain Physical Exam Perform sitting with leg hanging off table,stable to stress in one direction, loose in opposite direction Gross instability without an end point to varus or valgus stress 2 presentations: 1. Stable in full extension, AP instability at 90 of flexion. Cause Under-released concave structures Treatment If well-aligned, rebalance the collaberal ligaments by releasing the tight concave side to catch up with the loose convex side, then increase the polyethylene thickness Incompetent collateral ligaments not substituted for at primary surgery, trauma or iatrogenic injury Failure to equalize the flexion and extension gaps at primary surgery Revision to constrained condylar implant or hinge 2. Flexion contracture where extension gaps is too tight and knee is stable in flexion Type 3 Global instability © 2016 The Knee Society Can be subtle or severe-catching, giving way, lack of trust, anterior knee pain Knee goes into recurvatum and is also loose at 90 of flexion to AP stress, effusion common 28 Inadequate polyethylene thickness used at primary surgery to promote early range of motion Usually requires femoral component removal Step 1: Release posterior capsule by stripping up back of the distal femur to increase the extension gap If adequate either resect more distal femur to increase extension gap until gaps equal or increase the size of the femoral component adding posterior condylar augments to decrease flexion gap If well-aligned, increase thickness of polyethylene until stable in all planes Type 4 Posterior cruciate insufficiency Type 5 Combined instability pattern Symptoms Usually subtle, catching, giving way, lack of trust Physical Exam Knee is stable in extension, positive Drawer tests at 90 of flexion Cause Rupture or incompetence of posterior cruciate ligament Treatment Use of ultra-congruent anterior constrained poly if available or revision to a posterior stabilized femoral component The key to prosthetic knee instability is prevention at the time of primary surgery. A successful stable knee arthroplasty requires proper mechanical alignment, a complete concave release of the coronal deformity, and equalization of the flexion and extension gaps. References 1. Fehring TK, Valadie A: Knee Instability after Total Knee Arthroplasty: Clin Orthop Relat Res 299; 1994, 157-162. 2. Fehring TK, Odum S, Griffin WL, Mason JB, Nadaud M: Early Failures in Total Knee Arthroplasty, Clin Orthop Relat Res 392; 2001, 315-318. 3. Raab GE, Fehring TK, Odum SM, Mason JB, Griffin WL: Aspiration as an Aid to the Diagnosis of Prosthetic Knee Stability, Orthopedics 32 (5); May 2009, 318. 4. Brooks DH, Fehring TK, Griffin WL, Mason JB, McCoy TH: Polyethylene Exchange Only for Prosthetic Knee Instability, Clin Orthop Relat Res 405; 2002, 182-188. 5. Fehring TK, Odum S, Griffin WL, Mason JB: Outcome Comparison of Partial and Full Component Revision TKA, Clin Orthop Relat Res 440; 2005, 131-134. 6. Fehring TK: Rotational Malalignment of the Femoral Component in Total Knee Arthroplasty, Clin Orthop Relat Res 380; 2000, 72-79. © 2016 The Knee Society 29 8:21 am – 8:28 am Optimizing Risk Factors Richard Iorio, MD While TKA generally has favorable clinical outcomes in patients with advanced OA, there remains a risk of unfavorable outcomes. This includes operative and post-operative complications potentially leading to readmissions or revision surgery. Often these suboptimal outcomes are tied to comorbidities or complications associated with their TKA. Modifiable risk factors for poor clinical outcomes following TKA include: 1. morbid obesity, 2. poorly controlled diabetes and nutrition, 3. Staphylococcus aureus (S. aureus) colonization and Hepatitis C infection, 4. cardiovascular disease, 5. venous thromboembolic disease (VTED), 6. tobacco use, 7. neurocognitive, psychological and behavioral problems (including drug or alcohol dependency) and 8. physical deconditioning and fall risk. Together, these eight modifiable risk factors significantly account for avoidable complications and poor clinical outcomes following TKA. Identifying and modifying these risk factors prior to surgery presents an opportunity to decrease avoidable complications, improve clinical outcomes, and decrease costs associated with unnecessary health services utilization following these procedures. Although some of these modifiable risk factors may be longstanding and recalcitrant to change, patients may express a renewed interest in addressing them if they stand in the way of obtaining TKA, a procedure they hope will result in dramatic changes in pain, physical function and quality of life. The prospect of undergoing TKA may therefore provide an opportunity (i.e. “teachable moment”) to identify and manage such modifiable risk factors through shared decision making. By implementing risk factor optimization programs, we have lowered our complications and readmission rates after TKA. Our concept of a Perioperative Orthopaedic Surgical Home (POSH) to optimize patients preoperatively is the NYULMC plan to deal with these difficult patients. We have validated a POSH Readmission Scoring Tool which quantifies modifiable risk factors and predicts readmission risk, thus identifying patients who would benefit from surgery delay and risk factor optimization. Patients with a POSH Score of 3 had a 1.94 times higher risk of readmission, and with a score of 4 had a 4.21 times higher risk of readmission. This represents an overwhelming opportunity for cost savings, improvement in care and improvement in quality of life for our TKA patients. Optimization interventions based on modifiable risk factors • MRSA Screening and Decolonization, weight based antibiotic dosing, and use of Vancomycin and Gentamycin in high risk patients, Hepatitis C screening • Smoking cessation (hard stop) • Cardiovascular Optimization and Stroke Prevention (using PT, High dose Statins, and ACE inhibitors perioperatively) • Aggressive weight control (hard stop at a BMI of 40) • Catastrophizing avoidance • Drug and alcohol interventions • Fall education prevention • Physical deconditioning physical improvement interventions • Diabetes control and nutritional interventions • Screening for high risk VTED patients with thrombophyllia testing and risk stratification in order to avoid aggressive anticoagulation © 2016 The Knee Society 30 POSH Risk Factor Scoring Tool © 2016 The Knee Society 31 Summary Although improved care coordination can assist in increasing efficiency of care and controlling costs, it does not prevent all complications and readmissions. Patient selection and risk optimization is the key to decreasing readmissions and complications associated with patient related factors. References Boraiah, Sreevathsa; Joo, LiJin; Inneh, Ifeoma; Rathod, Parthiv; Meftah, Morteza; Band, Philip; Bosco, Joseph A. III; and Iorio, Richard: A Readmission Risk Assessment Tool to Manage Modifiable Risk Factors Prior to Primary Hip and Knee Arthroplasty. Journal of Bone and Joint Surgery, December, 2015, EPUB on line ahead of print. Bronson, Wesley; Lindsay, David; Lajam, Claudette; Iorio, Richard; Caplan, Arthur; Bosco, Joseph A: Ethics of Provider Risk Factor Modification in Total Joint Arthroplasty. Journal of Bone and Joint Surgery Am, 2015 Oct 07; 97(19):1635-1639. http://dx.doi.org/10.2106/JBJS.O.00564 Garvin, Kevin L.; Yu, Stephen; Healy, William L.; Pellegrini, Vincent D. Jr.; Iorio, Richard. ICL 65: Preventing Hospital Readmissions and Limiting the Complications Associated with Total Joint Arthroplasty. Journal of the American Academy of Orthopaedic Surgeons, J Am Acad Orthop Surg 2015;23: e60-e71. Iorio, Richard. Strategies and Tactics for Successful Implementation of Bundled Payments: Bundled Payment for Care Improvement at a Large, Urban, Academic Medical Center. Journal of Arthroplasty, Vol. 30, Issue 3, 349-50, 2015. Iorio, Richard; Clair, Andrew J.; Slover, James; and Zuckerman, Joseph D.: Early Results of CMS Bundled Payment Initiative for a 90 day Total Joint Replacement Episode of Care. Journal of Arthroplasty, 2015 Sep 9. pii: S0883-5403(15)00804-9. doi: 10.1016/j.arth.2015.09.004. [Epub ahead of print]PMID:26427938 Bronson WH; Fewer M; Godlewski K; Slover JD; Iorio, Richard; Bosco J; Caplan, A. The Ethics of Risk Modification Prior to Elective Joint Replacement Surgery. Journal of Bone and Joint Surgery, 96-A, 1143-50, 2014. Kiridly, DN; Karkenny, A; Hutzler, L; Slover, J; Iorio, Richard; Bosco, JA. The Effect of Severity of Disease on Cost Burden of 30-day Readmissions following Total Joint Arthroplasty (TJA). Journal of Arthroplasty, 2014, May, Vol. 29, No. 5. Pages 903-905. Guy Maoz, MD; Michael Phillips, MD; Joseph Bosco, MD; James Slover, MD, MS; Anna Stachel, MPH; Ifeoma Inneh, MPH; and Richard Iorio, MD. Modifiable vs. Non-Modifiable Risk Factors for Infection after Hip Arthroplasty. Clinical Orthopaedics and Related Research, Accepted for publication, Epub ahead of print July, 2014. © 2016 The Knee Society 32 8:29 am – 8:36 am Risk Stratified VTE Prophylaxis after Total Knee Arthroplasty Jay R. Lieberman, MD Professor and Chairman Department of Orthopaedic Surgery Keck School of Medicine of USC The selection of a prophylaxis agent is a balance between efficacy and safety. Total knee arthroplasty patients receive DVT prophylaxis because orthopaedic surgeons want to prevent the morbidity and mortality associated with pulmonary embolism. The selection of a prophylaxis agent is a balance between efficacy and bleeding. The prophylaxis must prevent symptomatic pulmonary embolism and DVT but at the same time avoid over anticoagulation which may lead to bleeding and other wound problems. Risk stratification is the key to effective prophylaxis. Although there is great interest in using risk stratification to select a prophylaxis regimen to use for a specific patient, there is no validated risk stratification strategy available today. There is general agreement at this time that patients who have had a prior PE or symptomatic DVT are at higher risk for development of a pulmonary embolism. In addition, there is a general belief that patients who have coagulation abnormalities (i.e. Factor V Leiden, Protein C and S deficiency) and higher body mass index are probably at increased risk of developing a VTE. The selection of a prophylaxis regimen should also be influenced by the ability to mobilize the patient after surgery. Further research on effective risk stratification strategies is needed. References 1. Lieberman, J.R., Pensak, M.J. Prevention of Venous Thromboembolic Disease After Total Hip and Knee Arthroplasty. J Bone Joint Surgery Am. 2013; 95(19):1801-1811. 2. Bohl, D.D., Maltenfort, M.G., Huang, R., Parvizi, J., Lieberman, J.R., DellaValle, C.J. Development and Validation of a Risk Stratification System for Pulmonary Embolism Following Elective Primary Total Joint Arthroplasty. Presented at the Annual Meeting of the American Association of Hip and Knee Surgeons. Dallas, TX. November 7, 2015. 3. Parvizi, J., Huang, R., Raphael, I.J., Arnold, W.V., Rothman, R.H. Symptomatic Pulmonary Embolus After Total Joint Arthroplasty: Stratification of Risk Factors. Clin Orthop Related Res. 2014 Mar; 472(3):903-12. © 2016 The Knee Society 33 Session II: TKA Alignment: Mechanical, Anatomic, or Kinematic 8:53 am – 9:00 am Mechanical Alignment Douglas A. Dennis, MD Adjunct Professor of Bioengineering, University of Denver Adjunct Professor, Dept. of Biomedical Engineering, University of Tennessee Asst. Clin. Professor, Dept. of Orthopaedics, University of Colorado School of Medicine Historically, poor mechanical alignment has been associated with premature failure of total knee arthroplasty (TKA) due to prosthetic loosening, polyethylene wear, and instability. Classic mechanical alignment as described by Insall requires placement of both the femoral and tibial components perpendicular to the mechanical axis (center of femoral head to center of the body of the talus). This has been the primary chosen method of alignment historically. Due to the normal adduction moment on the knee during single leg stance, varus placement of the tibial component increases this adduction moment, risking medial bone collapse and subsequent loosening. Numerous reports have confirmed that varus tibial component alignment is associated with accelerated wear and loosening, often associated with medial tibial osseous collapse. The combination of obesity and tibial component varus can dramatically increase failure. One analysis found that tibial component varus in subjects with a body mass index of > 33.7 kg/m2 had a 168X greater risk of TKA failure. The choice of mechanical alignment is supported by numerous clinical reports demonstrating implant survival greater than 90% at follow-up intervals greater than 15 years. Advocates of kinematic alignment report this method results in a more naturally feeling TKA with better patient satisfaction. Clinical reports have been favorable with this technique although followup duration is limited. Published data utilizing this method demonstrates tibial component varus is common (as high as 9) with 33% of knees positioned in less than 3 of femoral- tibial valgus which is worrisome for future failure. A recent computer simulation of TKA with kinematic alignment demonstrated increased medial tibial loads when compared to mechanical alignment. This method also risks placing the femoral component internally rotated relative to the transepicondylar axis which may increase patellar component loads and affect patellar tracking. Detailed published fluoroscopic kinematic studies of this technique to verify the reported advantages are lacking. Many unanswered questions remain with use of kinematic alignment. Is it safe to use in all subjects (varus and valgus knees, posterior cruciate retaining and substituting TKAs, etc) or is it best to use in only a selective group of subjects? Bibliography 1. Liu HX, Shang P, Ying XZ, Zhang Y. Shorter survival rate in varus-aligned knees after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2015. 2. Fang DM, Ritter MA, Davis KE. Coronal alignment in total knee arthroplasty: just how important is it? J Arthroplasty. 24(6 Suppl):39-43 2009. 3. Howell SM, Howell SJ, Kuznik KT, Cohen J, Hull ML. Does a kinematically aligned total knee arthroplasty restore function without failure regardless of alignment category? Clin Orthop Relat Res. 471(3):1000-7, 2013. © 2016 The Knee Society 34 9:01 am – 9:08 am Total Knee Arthroplasty-Anatomic Alignment Michael A. Mont, MD Restoration of the knee to neutral alignment is essential for a successful total knee arthroplasty (TKA), as malalignment has been linked with poor functional outcomes, accelerated implant wear, and early failure [1]. However, numerous studies suggest that up to 20% of patients may be dissatisfied following TKA, including those with well-aligned components [2, 3]. Various principles and surgical techniques have been developed in order to attain proper alignment, including advancements such as customized cutting guides and robot-assisted navigation [4]. Regardless of the modality used for implantation, anatomic alignment of the femur and tibia must be considered during preoperative planning to ensure optimal component placement. Using a long-leg standing radiograph, the anatomic axes can be defined by drawing a line proximal to distal in the intramedullary canals bisecting the femur and tibia, respectively. In order to restore anatomic alignment, the distal femur should be cut at 9 degrees valgus to its mechanical axis and the tibia should be cut at 3 degrees varus to its mechanical axis. The resultant 6 degrees of valgus approaches the normal tibiofemoral angle and creates a joint line that is parallel to the ground during normal gait [5]. This talk will focus on the pros and cons of using anatomic alignment and how the schema differs from other methods of assessing alignment for total knee arthroplasty. 1. 2. 3. 4. 5. Cherian, J.J., et al., Mechanical, Anatomical, and Kinematic Axis in TKA: Concepts and Practical Applications. Curr Rev Musculoskelet Med, 2014. 7(2): p. 89-95. Bourne, R.B., et al., Patient satisfaction after total knee arthroplasty: who is satisfied and who is not? Clin Orthop Relat Res, 2010. 468(1): p. 57-63. Noble, P.C., et al., The John Insall Award: Patient expectations affect satisfaction with total knee arthroplasty. Clin Orthop Relat Res, 2006. 452: p. 35-43. Kim, S.M., et al., Robot-assisted implantation improves the precision of component position in minimally invasive TKA. Orthopedics, 2012. 35(9): p. e1334-9. Hungerford, D.S. and K.A. Krackow, Total joint arthroplasty of the knee. Clin Orthop Relat Res, 1985(192): p. 23-33. © 2016 The Knee Society 35 9:09 am – 9:16 am Is Kinematically Aligned TKA a Good Alignment Option? Stephen M. Howell, MD Professor of Biomedical Engineering at UC Davis Sacramento, CA Kinematically aligned (KA) TKA has high outcome measures KA TKA balances the knee without release of the collateral ligaments and with retention of the PCL [1, 2]. KA TKA resulted in higher Oxford Knee and WOMAC scores and greater flexion than mechanically aligned (MA) TKA at 2 years in a randomized control trial [3]. KA TKA provided a 23and 20-point improvement in Oxford Knee Score, which is comparable if not greater than the 16 point improvement provided by unicompartmental arthroplasty [3-5]. Use of a KA TKA showed a trend towards more patients reporting a ‘normal’ feeling knee when compared to MA TKA in a national multicenter study [6]. A higher Oxford Knee Score predicts higher implant survival rates at 2, 5, 10, and 15 years according to New Zealand Arthroplasty Registry [7]. KA TKA minimizes tibial loosening and promotes implant survival The patient reported incidence of tibial loosening is 0.2% (5/2310) at 2-9 year after KA TKA (unpublished). All tibial loosening’s were from posterior subsidence which caused anterior lift off of the tibial component and was not associated with a Feb 2015 Oct 2011 varus mechanism of failure. Tibial loosening was minimal even though the KA tibial components were set in ‘varus’, undersized, and extended stems were not used even in obese patients. The 0.2% incidence of KA tibial loosening is comparable if not less than the 0.9% incidence tibial implant failure reported for MA TKA [8]. KA TKA has the same revision rate as MA TKA at 3 and 6 years[4, 8, 9]. The concern that kinematic alignment compromises function and places the components at a high risk for catastrophic failure is unfounded and should be of interest to surgeons committed to cutting the tibia perpendicular to the mechanical axis of the tibia [4, 9]. KA TKA is cost-effective in terms of readmission rate, length of stay, & discharge disposition For 2328 consecutive patients treated with a unilateral KA TKA between 2009 and 2014, the average length of hospital stay per year shortened from 2.0 to 1.3 days. The rate of discharge per year to a rehabilitation facility decreased from 41% to 1% and increased from 9% to 53% to home with outpatient physical therapy. The rate of readmission within 30 days per year did not change and averaged 1.1%. This all results to a cost savings averaged of $3245 per patient. In summary, the use of KA TKA enables a shorter length of hospital stay, an increased rate of discharge to home therapy, and low rate of readmission within 30 days and was cost effective [10]. References 1. Gu Y, Roth JD, Howell SM, et al.: How frequently do four methods for mechanically aligning a total knee arthroplasty cause collateral ligament imbalance and change alignment from normal in white patients? The Journal of Bone & Joint Surgery 96(12): e101, 2014. © 2016 The Knee Society 36 2. Roth JD, Howell SM, Hull ML: Native knee laxities at 0 degrees , 45 degrees , and 90 degrees of flexion and their relationship to the goal of the gap-balancing alignment method of total knee arthroplasty. J Bone Joint Surg Am 97(20): 1678, 2015. 3. Dossett HG, Estrada NA, Swartz GJ, et al.: A randomised controlled trial of kinematically and mechanically aligned total knee replacements: Two-year clinical results. Bone Joint J 96-B(7): 907, 2014. 4. Howell SM, Papadopoulos S, Kuznik K, et al.: Does varus alignment adversely affect implant survival and function six years after kinematically aligned total knee arthroplasty? Int Orthop: 1, 2015. 5. Pandit H, Jenkins C, Gill HS, et al.: Minimally invasive oxford phase 3 unicompartmental knee replacement: Results of 1000 cases. J Bone Joint Surg Br 93(2): 198, 2011. 6. Nam D, Nunley RM, Barrack RL: Patient dissatisfaction following total knee replacement: A growing concern? Bone Joint J 96-B(11 Supple A): 96, 2014. 7. The new zealand joint registry 14 year report: January 1999 to December 2012. (www.nzoa.org.nz/nz-joint-registry) 8. Ritter MA, Davis KE, Meding JB, et al.: The effect of alignment and bmi on failure of total knee replacement. J Bone Joint Surg Am 93(17): 1588, 2011. 9. Howell SM, Howell SJ, Kuznik KT, et al.: Does a kinematically aligned total knee arthroplasty restore function without failure regardless of alignment category? Clin Orthop Relat Res 471(3): 1000, 2013. 10. Barad SJ, Howell SM, Tom J: Is a shortened length of stay and increased rate of discharge to home associated with a low readmission rate and cost-effectiveness after primary total knee arthroplasty? Arthroplasty Today, In Press. © 2016 The Knee Society 37 9:17 am – 9:24 am Custom Cutting Guides Adolph V. Lombardi, Jr., MD, FACS Patient specific instruments have been developed in response to the conundrum of limited accuracy of intramedullary and extramedullary alignment guides and chaos caused by computer assisted orthopaedic surgery. This technology facilitates preoperative planning by providing the surgeon with a three dimensional (3-D) anatomical reconstruction of the knee, thereby improving the surgeon’s understanding of the preoperative pathology. Intramedullary canal penetration of the femur and tibia is unnecessary, and consequently, any potential for fat emboli is eliminated. Component position and alignment are improved with a decrease in the number of outliers. Patient specific instruments utilize detailed magnetic residence imaging (MRI) or computed tomography (CT) scans of the patient’s knee with additional images from the hip and ankle for determination of critical landmarks. From these studies a 3-D model of the patient’s knee is created and with integration of rapid prototyping technology, guides are created to apply to the patient’s native anatomy to direct the placement of the cutting jigs and ultimately the placement of the components. The steps in considering utilization of patient specific guides are as follows: 1) the surgeon determines that the patient is a candidate for TKA, 2) an MRI or CT scan is obtained at an approved facility in accordance with a specific protocol, 3) the MRI or CT is forwarded to the manufacturer, 4) the manufacturer creates the 3-D reconstructions, anatomical landmarks are identified, implant size is determined, and ultimately femoral and tibial component implant placement is determined via an algorithm, 4) the surgical plan is executed, 5) the physician reviews and modifies or approves the plan, 6) the guides are then produced via rapid prototyping technology and delivered to the hospital for the surgical procedure. Guides generated from MRIs are designed to uniquely register on cartilage surface whereas guides produced from CT scans must register on bony anatomy. There are currently two types of guides produced: those which register on the femur and tibia and allow for the placement of pins to accommodate the standard resection blocks; and those produced by some manufacturers which accommodate the saw blade and therefore are a combination of resection and pin guides. The utilization of patient-specific positioning guides in TKA has several benefits. They facilitate preoperative planning, obviate the need for violation of the intramedullary canals, reduce operating times and improve OR efficiency, decrease instrumentation requirements and thereby reduce potential for perioperative contamination. They are easier to use than computer navigation with no capital equipment purchase and no significant learning curve. Most importantly, patient-specific guides facilitate accurate component position and alignment, which ultimately has been shown to enhance long-term survivorship in total knee arthroplasty. 1. Lombardi AV Jr, Berend KR, Ng VY. Neutral mechanical alignment: a requirement for successful TKA: affirms. Orthopedics. 2011 Sep 9;34(9):e504-6. doi: 10.3928/01477447-20110714-40. 2. Lombardi AV Jr, Frye BM. Customization of cutting blocks: Can this address the problem? Curr Rev Musculoskelet Med. 2012 Dec;5(4):309-14. 3. Ng VY, DeClaire JH, Berend KR, Gulick BC, Lombardi AV Jr. Improved accuracy of alignment with patient-specific positioning guides compared with manual instrumentation in TKA. Clin Orthop Relat Res. 2012 Jan;470(1):99-107. © 2016 The Knee Society 38 9:25 am – 9:32 am Robotically-Assisted Knee Arthroplasty Jess H. Lonner, MD Attending Orthopaedic Surgeon, Rothman Institute Associate Professor of Orthopaedic Surgery, Thomas Jefferson University Philadelphia, PA Semi-autonomous robotic technology has been introduced to optimize accuracy of implant positioning and soft tissue balance in UKA, with the expectation of resultant improvement in durability and implant survivorship. Currently, nearly 20% of UKA’s in the U.S. are being performed with robotic assistance. It is anticipated that there will be substantial growth in market penetration over the next decade, projecting that nearly 37% of UKA’s and 23% of TKA’s will be performed with robotics in 10 years (Medical Device and Diagnostic Industry, March 5, 2015 [http://www.mddionline.com]). First generation robotic technology improved substantially implant position compared to conventional methods; however, high capital costs, uncertainty regarding the value of advanced technologies, and the need for preoperative CT scans were barriers to broader adoption. Newer image-free semi-autonomous robotic technology both optimizes implant position and soft tissue balance without the need for preoperative CT scans and with price points and portability that make it suitable for use in an ASC, where 40% of systems are being utilized. Two semi-autonomous robotic systems are available in the U.S. currently – one safeguards against inadvertent bone preparation by haptic constraint and requires preoperative CT imaging for the planning algorithm; the other modulates the exposure or speed of the handheld robotic bur to provide accuracy and does not require a preoperative CT scan. Both are utilized for UKA and PFA and are developing applications for TKA. Compared to conventional methods, both robotic systems have improved significantly the precision of bone preparation and reduced variance in implant position. Similarly, autonomous robotics have shown improved alignment in TKA. Unlike autonomous robotic technology in which inadvertent soft tissue injury occurred in 5% of cases, there have been no soft tissue injuries from either of the two semi-autonomous robotic sculpting tools in 800 consecutive cases performed by this author. Further study is needed to determine if the improved alignment and quantified soft tissue balance will lead to optimized functional outcomes or improved durability after knee arthroplasty. References 1. Lonner JH, John TK, Conditt MA. Robotic arm-assisted UKA improves tibial component alignment: a pilot study. Clinical Orthopaedics and Related Research 468(1):141-6, 2010. 2. Lonner JH, Smith JR, Picard F, Hamlin B, Rowe PJ, Riches PE. High Degree of Accuracy of a Novel Image-free Handheld Robot for Unicondylar Knee Arthroplasty in a Cadaveric Study. Clinical Orthopaedics and Related Research. 473:206-212, 2015 3. Conditt MA, Bargar WL, Cobb JP, Dorr LD, Lonner JH. Current concepts in robotics for the treatment of joint disease. Adv Orthop. Epub Dec 201 4. Dunbar NJ, Roche MW, Park BH, Branch SH, Conditt MA, Banks SA. Accuracy of dynamic tactile-guided unicompartmental knee arthroplasty. J Arthroplasty. 2012;27:803-808.e1. 5. Swank ML, Alkire M, Conditt M, Lonner JH. Technology and cost effectiveness in knee Arthroplasty: © 2016 The Knee Society 39 Computer navigation and robotics. Am J Orthop. 38 (2 suppl):32-36, 2009 6. Lonner JH. Robotically-Assisted Unicompartmental Knee Arthroplasty with a Hand-Held Image-Free Sculpting Tool. Orthop Clin N Am. 47:29-40, 2016 7. Song EK, Seon JK, Yim JH, Netravali NA, Bargar WL. Robotic-assisted TKA reduces postoperative alignment outliers and improves gap balance compared to conventional TKA. Clin Orthop. 471: 118126, 2013 © 2016 The Knee Society 40 9:33 am – 9:40 am Computer Navigation in Total Knee Arthroplasty: Past, Present, Future S. David Stulberg, MD The rationale for using computer technology to assist in the precise re-alignment of the leg and correct positioning of total knee implants is based upon evidence indicating that inferior functional performance, accelerated polyethylene wear and aseptic loosening of TKA implants is associated with limb and implant mal-alignment. At the time that the first total knee replacement procedure utilizing computer navigation was performed by Saragaglia, Picard and co-workers in Grenoble, France in 1997, the use of conventional surgical techniques, even in the hands of experienced knee arthroplasty surgeons, was associated with frequent limb and implant mal-alignment. It was also widely believed that less post-operative pain, better knee function, faster rehabilitation and an improved quality of life was related to appropriate limb and implant alignment ( 3 degrees of a mechanical axis of zero). Computer assisted navigation uses infrared technology to track the spatial position of the patient’s limb anatomy and the surgical instrumentation. It provides real-time information to guide bone cuts and allows measurement of the accuracy of these cuts. Systems can be classified into two, broad categories: closed (systems compatible with specific TKA components) and open (systems that are not specific to a single manufacturer, component type or instrumentation). The anatomic information upon which the intra-operative navigation is performed can be acquired either preoperatively from CT scans or intra-operatively using fluoroscopy (image-based CAS) or surfaceregistration techniques (image-free CAS). This information allows the system to construct a threedimensional model of the bony anatomy. The computer navigation software triangulates the location of registration markers placed in the femur and tibia. The system is then able to provide information regarding location of anatomic landmarks, limb axes, component position and centers of hip, knee and ankle joint rotation. The accuracy with which CAS systems can acquire and use this information has been extensively documented. Moreover, CAS techniques have become the basis for the use of a number of other computer based total knee technologies (e.g. robotic TKA). CAS technologies use instrumentation that is not a routine part of the surgeon’s total knee armamentarium. As a result, the learning curve to become proficient in the use of CAS-TKA is relatively long. The clinical reports of the alignment outcomes of CAS-TKA systems has not demonstrated a consistent improvement in coronal limb or implant alignment relative to alignment results with manual techniques. There is a suggestion in a number of reports that femoral component rotational alignment may be more accurate when CAS techniques are used. Moreover, meta-analyses indicate that the use of CAS-TKA is associated with a reduction in positioning outliers. In spite of possible improvements in implant and limb alignment, the use of CAS-TKA has not been associated with a consistent improvement in functional outcomes. Some reports have noted a decrease in revision rates at 5 years and a decreased revision rate in patients younger than 65. © 2016 The Knee Society 41 The developers of CAS-TKA technologies had hoped their utilization would be particularly helpful to inexperienced surgeons and useful for surgeons who did relatively few TKA’s. However, the lack of reported clear improvements in functional outcomes or consistent reductions in radiographic alignment outliers and the substantial cost of CAS units has resulted in a relatively low acceptance rate by surgeons doing TKA surgery. However, CAS is the basis for a number of emerging computer based TKA technologies. It is likely that the coming generation of TKA surgeons will need to become familiar with and proficient in CAS-TKA techniques. 1) Burnett, SJ, Barrack RL. Computer-assisted Total Knee Arthroplasty is Currently of No Proven Clinical Benefit: A Systematic Review. Clin Orthop Relat Res (2013) 471: 264-76. 2) Cheng T, Zhao S, Peng X, Zhang X. Does computer-assisted surgery improve postoperative leg alignment and implant positioning following total knee arthroplasty? A meta-analysis of randomized controlled trials. Knee Surg Sports Traumatol Arthrosc (2012) 20: 1307-22. 3) Leone WA, Elson LC, Anderson CR, A systematic Literature Review of Three Moalities in Technologically Assisted TKA. Adv Orthop. 2015: 719091 4) Ontario Health Technology Assessment Series 2004. Computer-Assisted Hip and Knee Arthroplasty. Navigation and Active Robotic Systems. An Evidence-Based Analysis. Vol 4, No 2. 5) Roberts TD, Clatworthy MG, Frampton CM, Young SW. Does Computer Assisted Navigation Improve Function Outcomes and Implant Survivability after Total Knee Arthroplasty? The Journal of Arthroplasty 30 Supl.1 (2015) 59-63. © 2016 The Knee Society 42 9:41 am – 9:48 am Mechanical Guides Robert E. Booth, Jr., MD Philadelphia, Pennsylvania Like it or not, the overwhelming majority of joint replacements around the world are implanted with manual instruments. They are our history, and for the foreseeable time, they remain our future. There is no question that even the present generation of manual instruments is being improved steadily as this abstract is written. We have yet to combine the lessons of ergonomics, of readability, of texture and surfacing, of shapes that speak to their task so that form and function become obvious and intuitive, etc. Most current instruments violate such common industrial principles as being sure the guide is sturdier and more secure than the tool it directs, that it serves multiple functions and minimizes the absolute number of steps in the procedure, that the attempt to make it shiny and attractive does not simultaneously make it slippery and droppable, and – perhaps most common of all – it can stand the inevitable blow from a mallet when its surgeon is frustrated. More and more expensive tools certainly exist, from patient specific pre-fabricated instruments, small “smart” devices to facilitate such surgeon failings as rotational alignment, disposable instruments, and “main frames” ranging from analogs of kinematic testing devices to Haptic robots to restrict the errant surgical hand. Unfortunately, none of these more expensive options has been shown to alter the clinical outcome from the functional standpoint even though the number of “outriders” is often reduced. In truth, the greatest economy at present is a combination of improved manual tools and the ergonomic study of their implementation by the operating surgeon. If equivalent long term functional results can and are being achieved with conventional instruments, perhaps attention should be equally directed to the efficient handling of these tools rather than blaming the instrument itself. Bibliography 1. Abane L, Anract P, Boisgard S, Descamps S, Courpied JP, Hamadouche M.: Patient-Specific Cutting Guides Were Not Better Than Conventional Instrumentation for Total Knee Arthroplasty. Evidenced-Based Orthopaedics Commentary by William M. Mihalko, M.D., PhD. JBJS 2015 Nov 18; 97-A (22)1891. 2. Denis Nam MD, Andrew Park MD, Jeffrey B. Stambough MD, Staci R. Johnson Med, Ryan M. Nunley MD, Robert L. Barrack MD: Custom Cutting Guides Do Not Improve Total Knee Arthroplasty Clinical Outcomes at Two Year Follow-up. Symposium 2015 Knee Society Proceedings. The Mark Coventry Award, Clinical Orthopaedics & Related Research e-pub February 25, 2015, 1-7. © 2016 The Knee Society 43 3. Xie C, Liu K, Xiao L. Tang R: Clinical Outcomes After Computer-Assisted vs. Conventional TKA. Orthopaedics 2012 May 35(5)e647-e653. 4. Mason JB, Fehring TK, Estok R, Banel D, Fahrbach K: “Meta Analysis of Alignment Outcomes in Computer-Assisted Total Knee Arthroplasty Surgery”. Journal of Arthroplasty 2007 22(8)10971105. 5. Brin YS, Nikolaou VS, Joseph L, Zukor DJ, Antoniou J: Imageless Computer vs. Conventional Total Knee Replacement. International Orthopaedics (SICOT) 2011 (35)331-339. © 2016 The Knee Society 44 Session III: The Painful TKA: Prevention, Evaluation, and Management 10:16 am – 10:23 am Managing Expectations Michael J. Dunbar, MD, FRCSC, PhD Dalhousie University Halifax, Nova Scotia, Canada “I did really cry in good earnest when I went to bed, to think that my expectations had done some good to somebody” Pip, Great Expectations. Unmet expectations after TKA have been shown to be the largest determinant of dissastisfaction. Subsequently, managing patient expectations regarding their TKA is vital to optimize postoperative outcomes, especially in terms of satisfaction. Patient’s expectations should obviously be addressed prior to surgery and efforts should be made in the patient interview to understand specifically what the patients expectation’s are. Satisfaction after TKA correlates with relief of pain, followed by improvement in physical function. As such, it is important to understand the nature of the patient’s pain and any features of chronicity, such as opioid use or catastrophizing that may result in chronic postoperative pain. Patients should be cautioned that it is normal to have some residual pain after TKA, especially with activity, and that some functions such as kneeling, climbing stairs, and walking on uneven ground can be difficult. Patients may not be able to return to levels of sporting activity that they are anticipating. It is vitally important that your patient understands that these limitations can be associated with TKA outcomes. Understanding and resetting patient’s expectation’s is an important part of the informed consent process. Satisfaction is a function of the chronicity of disease process leading to TKA, with patients with long standing disease states reporting higher rates of satisfaction than those with acute onset pathologies, such as avascular necrosis. Because TKA has been offered to younger patients, often earlier in the disease process, the younger patient’s expectations are particularly problematic in obtaining reliable rates of high satisfaction. Ultimately, TKA is a salvage procedure utilizing metal and plastic, and it is sometimes prudent to advise patients of that fact. Selected Readings Baker PN, van der Meulen JH, Lewsey J, Gregg PJ, National Joint Registry for E, Wales. The role of pain and function in determining patient satisfaction after total knee replacement. Data from the National Joint Registry for England and Wales. J Bone Joint Surg Br 2007;89-7:893-900. Bourne RB, Chesworth BM, Davis AM, Mahomed NN, Charron KD. Patient satisfaction after total knee arthroplasty: who is satisfied and who is not? Clin Orthop Relat Res 2010;468-1:57-63. © 2016 The Knee Society 45 Dunbar MJ, Richardson G, Robertsson O. I can't get no satisfaction after my total knee replacement: rhymes and reasons. Bone Joint J. 2013 Nov;95-B(11 Suppl A):148-52 Husain, A. and G. C. Lee (2015). "Establishing Realistic Patient Expectations Following Total Knee Arthroplasty." J Am Acad Orthop Surg 23(12): 707-713. Robertsson O, Dunbar M, Pehrsson T, Knutson K, Lidgren L. Patient satisfaction after knee arthroplasty: a report on 27,372 knees operated on between 1981 and 1995 in Sweden. Acta Orthop Scand 2000;71-3:262-7. Robertsson O, Dunbar MJ. Patient satisfaction compared with general health and disease-specific questionnaires in knee arthroplasty patients. J Arthroplasty 16-4:476-82. Sullivan, M., et al. (2011). "The role of presurgical expectancies in predicting pain and function one year following total knee arthroplasty." Pain 152(10): 2287-229 © 2016 The Knee Society 46 10:24 am – 10:31 am Optimizing Emotional Health in TKR Patients David C. Ayers, MD Franklin P, Li W, Ayers D. The Chitranjan Ranawat Award: Functional Outcomes after TKR Varies with Patient Attributes. Clin Orthop Related Res, Nov 2008, 466(11) p2597-2604. The analysis of this national primary TKR cohort demonstrates two post-TKR outcome distributions; one for high pre-TKR emotional health (MCS>50) and one for low pre-TKR emotional health (MCS<50). The majority of post-TKR patients with stronger emotional health reported improvement in function. However, the low emotional health group (MCS < 50) distribution was almost flat with large numbers of patients reporting no improvement in PCS at 12 months. While it is accepted that emotional health influences functional gain after TKR, the relationship is not clearly understood. This analysis supports the importance of addressing emotional health issues in the perioperative TKR process. Ayers D, Franklin P, Trief P, et al. The Psychological Attributes of Preoperative Total Joint Replacement Patients: Implications for Optimal Outcome. J. Arthroplasty, Oct 2004, 19 (7): p125130. What characterizes patients with a low pre-op MCS? Patients with preoperative MCS <50 had significantly higher trait anxiety, subclinical depression, poor coping skills, lower social support and reported more catastrophizing and poorer pain control than patients with high pre-op MCS. Franklin P, Karbassi J, Ayers D. Reduction in Narcotic Use after Primary TKR and Association with Pain Relief and Satisfaction. J Arthroplasty Sept 2010, 25 (6) Examined the prevalence of narcotic use before and after TKA and it association with post-TKR pain relief and patient satisfaction. Patient who used narcotics before TKR were more likely to have a narcotic prescription at 12 months post-op, reported greater pain at 12 months post-op, and were more likely to be dissatisfied with TKR outcome. Franklin P, McLaughlin J, Ayers D. Methods to Document Quantity and Variation of Independent Patient Exercise after TKA. J Arthroplasty Sept. 2006, 21 (6): p 157-163 Rosal M, Ayers D, Franklin P. A randomized Clinical Trial of a periopertive behavioral intervention to improve physical activity adherence and functional outcomes following TKR. BMC Musculoskeletal Disorders. Oct 2011. Post-operative outcomes following TKR in patients with low pre-op emotional health may benefit from a peri-operative pathway that provides additional peri-op counseling, coping strategies, social support. Patients with emotional comorbid conditions may be best managed by a tailored pathway designed to address patient specific issues; approach is similar to how medical comorbidites are managed perioperatively. Ayers D, Franklin P, Ring D. The role of Emotional Health in Functional Outcomes after Orthopaedic Surgery. J Bone Joint Surg Am, Nov 2013, 95 (21), pe 165 Low pre-op MCS negatively affects patient post-operative outcome following many different types of orthopedic surgery. © 2016 The Knee Society 47 10:32 am – 10:39 am Pre- and Post-Operative Opioid Management Thomas Parker Vail, MD James L. Young Professor and Chairman Department of Orthopaedic Surgery University of California, San Francisco While narcotic pain medication remains a helpful adjunct in the care of patients undergoing total knee replacement, the misuse and overuse of narcotic pain medication in the perioperative period can adversely affect the outcome of total knee replacement patients. The prevalence of prescription drug, reportedly extending to more than half of the US population, naturally is reflected in orthopaedic patients. Astoundingly, the US consumes more than three quarters of the world supply of opiate analgesics. In a 2014 Senate caucus on International narcotics control, it was reported that “between 26.4 million and 36 million people abuse opioids worldwide, with an estimated 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers in 2012.” In a recent study conducted by Sing at UCSF, we found the prevalence of preoperative opioid use for patients undergoing primary TJA for OA to be 35% overall with 5% of all TJA candidates using long-acting formulations for pain control. The role for preoperative opioid use and the optimal management of opioid-dependent patients in the perioperative setting remains unclear. While the proposed AAOS clinical practice guideline on surgical management of osteoarthritis of the knee (SMOAK) does not specifically address the treatment of OA with opioid medications, recommendations from the American College of Rheumatology, American Geriatrics Society, and American Pain Society guidelines support prescribing opioids for chronic relief of OA. Results of the UCSF Sing study demonstrated that preoperative opioid use was associated with significantly worse early postoperative outcome, including longer length of stay, higher rates of discharge to facility, and increased complications within 90 days. Furthermore, this detrimental association was more severe with the use of long-acting opioid formulations. Additional work by Nguyen at UCSF suggests that the preoperative use of narcotic pain medication is a potentially modifiable risk factor. Specifically, the prospective work by Nguyen and others suggests that decreasing narcotic consumption prior to surgery and converting from longer acting narcotic medication to shorter acting medication may positively impact length of stay, success of postoperative pain management, and risk for perioperative complications. As a result of these observations, pain management protocols at UCSF continue to employ a comprehensive approach to pain management utilizing elements of shared decision making, multimodal non-narcotic drug (acetaminophen, gabapentin, and celecoxib) protocols, adductor canal femoral nerve blocks, non-pharmacologic strategies such as PT and cryotherapy, optimization of preoperative narcotic use to the shortest acting and lowest dose that is clinically effective, avoidance of parenteral narcotic usage entirely, and careful post-operative monitoring with rapid tapering narcotic usage after surgery. © 2016 The Knee Society 48 10:40 am – 10:47 am The Role of “Pain Management” Craig J. Della Valle, MD; Adam Young MD; Asokumar Buvanendran, MD Rush University Medical Center, Chicago, IL Unfortunately, a substantial number of patients report persistent pain after total knee arthroplasty. Once mechanical and septic causes of failure have been ruled out, the clinician should consider Chronic Post-Surgical Pain Syndrome. This syndrome often features neuropathic pain as a component, which is different than the typical pain experienced following surgery. While our training as orthopaedic surgeons does not make us optimal providers of treatment, some understanding of the clinical signs of this entity can assist the clinician in making appropriate referrals to a pain management specialist to better manage these patients. While the etiology of chronic post-surgical pain syndrome is not entirely clear, several pre- and postoperative risk factors have been elucidated. Such factors include severe preoperative pain, preoperative narcotic use, anxiety/depression, and psychological traits such as catastrophisizing. A genetic predispotision has also been suggested. Poorly controlled pain in the immediate postoperative period has a strong correlation to chronic post-surgical pain syndrome. Prevention of any adverse outcome is always desired, and the use of mulit-modal analgesia and avoiding severe pain in the early postoperative period may reduce the risk of this complication. Similarly, there is evidence that the perioperative use of pregabalin (Lyrica®) and gabapentin (Neurontin®) may reduce the risk of chronic post surgical pain. These medications were origially used as anticonvulsants, but have recently been shown to be effective in treating neuropathic pain. These disorders are typically characterized by pain that endures for more than 2 months postoperatively and is associated with cutaneous hypersensitivity (allodynia), burning type sensations, color changes of the overlying skin, swelling of the leg, and in some cases contractures of the joint. The presence of multiple symptoms can suggest a more serious pain condition developing, such as complex regional pain syndrome (CRPS). Once a patient develops chronic post-surgical pain syndrome, treatment can be challenging. A multimodal approach to treatment includes not only narcotic pain medication, but nerve stabilizing drugs such as pregabalin, topical anesthetics, anti-inflammatory medications, non-narcotic analgesics and anti-depressants. Other options include sympathetic nerve blocks and spinal cord stimulation. References Buvanendran A, Kroin JS, Della Valle CJ, et. Al. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty. Anesth Analg. 2010 Jan 1;110(1):199-207. Elmofty DH, Anitescu M, Buvanendran A. Best practices in the treatment of neuropathic pain. Pain Manag. 2013 Nov;3(6):475-83. Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants. Pain 2011;152:566–72 © 2016 The Knee Society 49 Session IV: Transitioning to Value-Based Healthcare 11:04 am – 11:11 am Bundled Payments and Other Value-Based Payment Strategies Kevin J. Bozic, MD, MBA Healthcare delivery is extremely fragmented in the current landscape, with poor coordination among providers, minimal transparency around outcomes and costs, and a system that rewards high-cost, intensive medical interventions over higher-value, patient-centered care. In this context, payers, providers and policymakers are increasingly focused on identifying delivery payment models to align incentives among stakeholders to improve the value (outcomes and patient experience divided by cost) of care 1,2. One such model is bundled payments in which the care team and hospital are accountable for outcomes, care utilization, and costs up to 90 days post-discharge 3. In order to succeed in this model, the bundle team must first identify clinical and administrative champions to lead care redesign efforts, and engage relevant stakeholders. The team must map the episode pathway in detail, assess episode outcomes and cost data, and identify the most impactful areas for care redesign and cost reduction. Through multidisciplinary stakeholder input, evidence-based approaches, and group consensus, the care team will implement and continuously iterate on interventions to improve quality and cost performance. Several total joint replacement bundle demonstrations improved outcomes (e.g., lower 90-day readmissions) while reducing resource utilization and achieving operational efficiencies 3-6. Medicare recently finalized the Comprehensive Care for Joint (CJR) Replacement model which mandates bundled payments for primary TJR in 67 geographic areas 7. In CJR, hospitals are incentivized to collect patient-reported outcomes such as change in pain and functional status, with the ultimate goal of determining how PROs can be used to assess TJR appropriateness and value. References 1. Porter ME. What is value in health care? The New England journal of medicine. Dec 23 2010;363(26):2477-2481. 10.1056/NEJMp1011024 2. Porter ME, Pabo EA, Lee TH. Redesigning primary care: a strategic vision to improve value by organizing around patients' needs. Health affairs. Mar 2013;32(3):516-525. 10.1377/hlthaff.2012.0961 3. Bozic KJ, Ward L, Vail TP, Maze M. Bundled payments in total joint arthroplasty: targeting opportunities for quality improvement and cost reduction. Clinical orthopaedics and related research. Jan 2014;472(1):188-193. 10.1007/s11999-013-3034-3 4. Iorio R. Strategies and tactics for successful implementation of bundled payments: bundled payment for care improvement at a large, urban, academic medical center. The Journal of arthroplasty. Mar 2015;30(3):349-350. 10.1016/j.arth.2014.12.031 5. Bosco J, Shah PC, Slover JD, Torrance A. Optimizing the OR for bundled payments: a case study. Bulletin of the American College of Surgeons. Nov 2014;99(11):29-36 6. Sood N, Huckfeldt PJ, Escarce JJ, Grabowski DC, Newhouse JP. Medicare's bundled payment pilot for acute and postacute care: analysis and recommendations on where to begin. Health affairs. Sep 2011;30(9):1708-1717. 10.1377/hlthaff.2010.0394 7. Centers for Medicare and Medicaid Services Comprehensive Care for Joint Replacement Model Ruling Proposal. August 25 2015 © 2016 The Knee Society 50 11:12 am – 11:19 am The Role of the EMR in Improving Value Wael K. Barsoum, MD The Health Information Technology for Economic and Clinical Health Act authorized $27 billion over a period of 10 years to promote meaningful use of electronic health records (EHR). Promises of the implementation of EHRs in our hospitals included improvements in health care quality, prevention of medical errors, reductions in health care costs, increased administrative efficiency, and national remote access to patient records1. This change was accompanied by healthcare reform and the shift from a volume-driven system to a value-based payment structure. The early promises of EHR implementation appear to easily align with the goals of a value-based system, but there is debate as to whether or not EHRs have lived up to this potential. Studies have focused on addressing the question as to whether hospitals with EHR actually provide a higher quality of care compared with those that do not2,3. Kazley et al2. reported on 10 quality process indicators and concluded that there was a positive significant relationship between EHR use and 4 of the 10 indicators. A systematic review of the literature included 53 review studies to assess the impact of EHR on the quality of care, and reported a weak impact on efficiency, both increased and decrease workload, and a change in behavior which did not translate into higher quality of care in terms of improved patient outcomes3. At the Cleveland Clinic, we implemented a CarePath using our EHR in 2013, which utilizes standardized admission orders, optimized presurgical orders, a documentation checklist, relatively standardized postoperative care, SCIP measure optimization, and standardized discharge summaries. This effort has resulted in improved communication, decrease average length of hospital stay (0.5 days less for THA, 0.2 days less for TKA), and decreased blood utilization (130 cc less for THA, 30 cc less for TKA). A second key promise of EHR is the reduction in health care cost by improvements in efficiency. Reed et al4. studied staggered EHR implementation across outpatient clinics from 2005-2008 on a population of 169,711 patients, and compared emergency department (ED) visits, hospitalizations, and office visits use between those with and without EHR use. Multivariable analysis showed a significant reduction in ED visits (28.80 fewer visits per 1,000 patients annually) and fewer hospitalizations (13.10 fewer per 1,000 patients annually). There was no significant association between EHR use and office visits. Kazley et al5. used the National Inpatients Sample and Health Information Management Systems Society from 2009 to analyze 5,047,089 cases, 1,509,610 (29.9%) of which were cared for in hospitals with advanced EHRs. The study showed that patient costs were on average 0.0966% (or $731) lower than that of patients treated in hospitals without advanced EHR. However, whether this is due to efficiency improvements is questionable in the eyes of the end uses, as Black Book’s Q3 2014 Loyalty Poll surveyed 14,000 nurses, of which 94% said communication did not improve and that dissatisfaction had “reached an all-time high”. © 2016 The Knee Society 51 To date, there is little evidence available that investments in EHR quickly translate into direct benefits to patients and/or providers. The direct and indirect costs are not being offset by measureable improvements. However, improvements in documentation are noticeable benefits, and patience may be required to realize the full benefit of EHR implementation. Improvements to EHRs are constantly evolving, with the potential to raise realized benefits. 1. 2. 3. 4. 5. US Department of Health& Human Services. 2014; http://healthit.hhs.gov/portal/server.pt/community/healthit_hhs_gov_home/1204. Kazley AS, Ozcan YA. Do hospitals with electronic medical records (EMRs) provide higher quality care?: an examination of three clinical conditions. Med Care Res Rev. Aug 2008;65(4):496-513. Black AD, Car J, Pagliari C, et al. The impact of eHealth on the quality and safety of health care: a systematic overview. PLoS Med. 2011;8(1):e1000387. Reed M, Huang J, Brand R, et al. Implementation of an outpatient electronic health record and emergency department visits, hospitalizations, and office visits among patients with diabetes. JAMA. Sep 11 2013;310(10):1060-1065. Kazley AS, Simpson AN, Simpson KN, Teufel R. Association of electronic health records with cost savings in a national sample. Am J Manag Care. Jun 2014;20(6):e183-190. © 2016 The Knee Society 52 11:20 am – 11:27 am The Role of Registries in Improving Value Colin Howie MB ChB, FRCS, FRCS(Orth) Ed UK Registries are often used to identify the benefits of specific implants or techniques. However perhaps their most important role is to highlight what is doing well in our service. While bundled payments and private healthcare systems will act to control cost at the most expensive point of delivery; the operating theatre; perhaps the bigger long term costs to our patients and society are the costs of complication, infection, stiffness and instability resulting in early revision. Variation in healthcare has been used to look at rates of interventions per head of population. We have looked at the rates of complication variation and reported the results back to surgeons as part of an ongoing quality improvement strategy. Using standards achieved in other hospitals in similar healthcare settings rather than top down mandated targets the rates of complication have been reduced and significant savings achieved for the healthcare system in general. Our patients have benefitted from better outcomes. © 2016 The Knee Society 53 11:28 am – 11:35 am Integrated Delivery Systems are Key to Value Creation Mark Froimson, MD, MBA Trinity Health Healthcare in general, and joint replacement in particular, has come under fire for being of uneven quality and cost, without a direct correlation between the two. As a result, payers and regulators are attempting to correct this perceived deficiency by incentivizing providers, that is physicians and health systems, to focus on the value of the care provided. While there is general agreement that both quality improvement and cost reduction are tandem paths to value creation, there is less agreement on the best models for achieving one or both of these. Waste and unnecessary interventions are commonly cited reasons for excess cost and lack of quality. Duplication of services occurs when there is lack of communication and coordination and when practitioners attempt to ply their craft in traditional silos. The move to alternative payment models has begun to shed light on the importance of care coordination and transitions of care, in eliminating redundancy and ensuring compliance with prescribed treatments. Such seamless care requires that providers know one another, that there are common and accepted pathways across the continuum, that communication is fostered, that follow up is assured and that complications and deviations from the expected course are managed by those with the most knowledge of the patient. Although such care can occur in a virtual network of providers who are well known to each other, there is increasing evidence that the most reliable way to ensure such quality and efficiency is through the creation of integrated delivery systems. Such systems can take the form of a unified entity with a single business model, but can also exist in the form of a clinically integrated network that is linked by shared agreements between independent entities. It is the degree of integration that matters more than the financial ties of the parties delivering the care. References Bhatt, Purvi B., Forster Kevin, Walter Terri L., Survive or Thrive? Healthcare Financial Management, July 2015, p62-67. Carlin Caroline S., Dowd Bryan, Feldman Roger, Changes in Quality of Health Care Delivery after Vertical Integration, Health Services Research, August 2015, p. 1043-1069. Hwang Wenke, PhD, Chang Jongwha, PhD, LaClair Michelle, MPH, Paz Harold, MD, MS, Effects of Integrated Delivery System on Cost and Quality, The American Journal of Managed Care, May 2013, Vol 19, No. 5, e175-e184. © 2016 The Knee Society 54 Jacquin Laura, A Strategic Approach to Healthcare Transformation, Healthcare Financial Management, April 2014, p.74-79. May, Ellen Lanser, Achieving Physician-Led Clinical Integration, Healthcare Executive, Jan/Feb 2015, p11-17. Moore, Keith D., Eyestone, Katherine M., Coddington Dean C., The Integration Aspiration, Healthcare Financial Management, June 2014, p56-59. Redding John, Achieving Clinical Integration, Healthcare Financial Management, November 2013, p. 56-61. Sharan Alok D., MD, MHCDS, Schroeder Gregory D., MD, West, Michael E., MBA, CPA, Vaccaro Alexander R., MD, PhD, MBA, Business of Medicine, Spinal Disord Tech, Vol 00, Number 00, 2015, p1-3. Squazzo Jessica D., The Journey to Value-based Care for Population Health, Healthcare Executive, Jan/Feb 2015, p28-35. Psek, Wayne A., Stametz Rebecca A., Bailey-Davis Lisa D., Davis Daniel, Darer, Jonathan, Faucett William A., Henninger Debra L., Sellers Dorothy C., Gerrity Gloria, Operationalizing the Learning Health Care System in an Integrated Delivery System, The Berkeley Electronic Press, 2015, p1-11. Teisberg Elizabeth O., Phd, Wallace Scott, JD, MBA, Creating a High-Value Delivery System for Health Care, Semin Thorac Cardiovasc Surg 21, 2009, p.35-42. © 2016 The Knee Society 55 11:36 am – 11:43 am Transitioning from Volume to Value: Private Practice Models are More Nimble Daniel B. Murrey, MD, MPP The drive to transition from volume to value assumes that the market will reward value creation: improvement in outcomes that matter to patients and/or a reduction in the cost to achieve those outcomes. The relative complexity of the care environment in which orthopedics is practiced slows adoption of new processes, but equally important is the complexity of governance in these institutions. In larger organizations such as health systems, the decision to change processes and strategy require not only buy-in from involved clinicians, but also approval of the operational teams, finance teams, and clinical support teams. These are often separate decision-making bodies with relatively independent authority. Because the clinicians are also the owners and governors of private physician practices, the buy-in of physician leadership is the only gating step to adoption of a value agenda assuming adequate capital and commitment to data transparency and accountability. © 2016 The Knee Society 56 THE KNEE SOCIETY AWARDS The John N. Insall, MD Award 1:01 pm – 1:11 pm Do Injections Increase the Risk of Infection Following TKA? Nicholas A. Bedard, MD; Andrew J. Pugely, MD; Jacob M. Elkins, MD, PhD; Kyle R. Duchman, MD; Robert W. Westermann, MD; Steve S. Liu, MD; Yubo Gao, PhD; John J. Callaghan, MD Background Infection following TKA can result in disastrous consequences. Previous research regarding injections and risk of TKA infection have produced conflicting results and have been greatly limited by small cohort size. The purpose of this study was to evaluate if injection prior to TKA increases the rate of post-operative infection and identify if time between injection and TKA effect the rate of TKA infection. Methods The Humana dataset was reviewed from 2007-2014 for all patients who received a knee injection prior to TKA. CPT codes and laterality modifiers were used to identify patients who underwent knee injection followed by ipsilateral TKA. Postoperative infection within six months of TKA was identified using ICD-9/CPT codes and compared between cohorts based upon duration between injection and TKA. Results In total, 29,603 patients (35.4%) had an injection in the ipsilateral knee prior to TKA and 54,081 patients (64.6%) did not. Rates of any post-operative infection were significantly higher in patients with an injection than those without (4.4% vs 3.6%), as were rates of infection requiring return to the operating room (1.5% vs 1.0%). Odds ratios for these endpoints were 1.2 and 1.4, respectively (p<0.001 for both). Analysis by proximity between injection and TKA revealed the odds of any postoperative infection remained significantly higher for the injection cohort out to a duration of 6 months between injection and TKA, as did the odds of operative innervation for TKA infection when injection occurred within 7 months of TKA. When the duration between injection and TKA was longer than 6 or 7 months, the odds ratios were no longer significantly elevated at these endpoints, respectively. Conclusions Injection prior to TKA was associated with a higher odds of post-operative infection and appears to be time dependent with closer proximity between injection and TKA having increased odds of infection. © 2016 The Knee Society 57 The Chitranjan S. Ranawat, MD Award 1:12 pm – 1:22 pm No Difference in Two-Year Functional Outcomes Using Kinematic Versus Mechanical Alignment in TKA Simon W. Young, FRACS; Matthew L. Walker, FRACS; Ali Bayan, FRACS; Toby Briant-Evans, FRCS; Paul Pavlou, FRCS, Bill Farrington, FRCS, FRACS Background Neutral mechanical alignment (MA) in total knee arthroplasty (TKA) aims to position femoral and tibial components perpendicular to the mechanical axis of the limb. In contrast, Kinematic Alignment (KA) matches implant position to the pre-arthritic anatomy of the individual patient, with the aim of improving functional outcome. However comparative data between the two techniques is lacking. Questions/Purposes (1) Are two-year patient-reported outcome scores enhanced in patients with KA compared to MA technique? (2) How does post-operative component alignment differ between the techniques? (3) (3) Does the rate of two-year complications requiring re-operation differ? Methods Ninety-nine primary TKAs were randomized to either MA (n=50) or KA (n=49) groups. In the KA group, patient specific cutting-blocks were manufactured using individual pre-operative MRI data. In the MA group, computer navigation was used to ensure neutral mechanical alignment accuracy. Post-operative alignment was assessed with CT scan, and functional scores were assessed preoperatively and at 6 weeks, 6 months, 1 and 2 years postoperatively. Results There was no difference in 2-year change scores (post-op minus pre-op score) in KA versus MA patients for the Oxford Knee Score (21.9 vs 20.0, p=0.4), Western Ontario and McMaster Universities score (38.3 vs 35.1, p=0.32), or Forgotten Joint score (29.2 vs 26.7, p=0.8). Postoperative hip-knee-ankle axis was similar between groups (KA 0.4° vs MA 0.7° varus), but in the KA group the tibial component was in mean 2.1° more varus than the MA group (95% CI 1.0°-3.2°, p=0.0003) and the femoral component in 1.4° more valgus (95% CI 0.55°-2.3° p=0.003). Complication rates were similar between groups. Conclusion We found no difference in two-year patient reported outcome scores in TKAs implanted using the KA versus MA technique. Currently, it is unknown if the alterations in component alignment seen with KA will compromise long-term survivorship of TKA. Level of Evidence Level 1 Therapeutic Study, Randomized Controlled Trial © 2016 The Knee Society 58 The Mark Coventry, MD Award 1:23 pm – 1:33 pm Oral Antibiotics Reduce Reinfection Following 2-Stage Exchange: A Multi-Center, Randomized Controlled Trial Craig J. Della Valle, MD; Jonathan M. Frank, MD; Erdan Kayupov, MSE; Mario Moric, MA; John Segreti, MD; Erik Hansen, MD; Curtis Hartman, MD; Kamil Okroj Background A substantial number of patients develop recurrent periprosthetic joint infection (PJI) following twostage exchange arthroplasty. One potential strategy to decrease the risk of failure is to administer additional antibiotics after the second stage reimplantation. Questions/Purposes 1. Does 3 months of oral antibiotics decrease the risk of failure following a two-stage exchange? 2. Are there any complications related to the administration of oral antibiotics following a two-stage exchange? 3. In those patients that have a reinfection, is the infecting organism different from the initial infection? Patients and Methods Following Institutional Review Board approval seven centers enrolled patients who were randomized to receive three months of oral antibiotics or no further antibiotic treatment after operative cultures following the second stage reimplantation were negative. Oral antibiotic therapy was tailored to the original infecting organism(s) in consultation with an Infectious Disease specialist. A priori power analysis determined that 77 patients per group would be required to demonstrate a reduction in infection recurrence from 16% to 4% (β=0.80 and α=0.05). A logrank survival curve was used to analyze the primary outcome of reinfection. Results Forty-five patients were successfully randomized to the antibiotic group and 47 patients to the control group. The mean follow-up was 14.8 months in the antibiotic group and 10.1 months in the control group. There have been three failures in the antibiotic group compared to nine amongst controls (7% vs 19%; p=0.0457 using log rank survival curve analysis). Four patients had an adverse reaction to the oral antibiotics and four patients were noncompliant with taking them. Eight of the nine failures in the control group were with new organisms and two of the three failures in the antibiotic group were with the same organism. Conclusions This multicenter randomized trial suggests that at short-term follow-up, the addition of three months of oral antibiotics significantly improved infection-free survival. Further follow up of this cohort of patients will be necessary to determine if these results are durable over time. Level of Evidence Level of Evidence Level 1, randomized control trial study. © 2016 The Knee Society 59 Session VII: Case Presentations 2:51 pm – 2:58 pm When is TKA Appropriate? Ryan M. Nunley, MD Introduction 1. TKA is one of the most successful operative procedures in Orthopaedic Surgery 2. Clear evidence that utilization of TKA will continue to increase over next 20 years 3. Implant design, durability, and surgical technique have improved long term outcomes 4. Patient selection, pre-operative optimization, and minimization of perioperative complications is increasingly more important with the transition to bundled payments Review the role of conservative management 1. Viscosupplementation injections-controversy over efficacy and AAOS guidelines 2. Steroid injections- timing and number of injections prior to TKA may influence outcome 3. Role of Physical therapy 4. Role of weight loss Risk Factors 1. Too young or too old….Is there a sweet spot for age at time of TKA? 2. Previous knee arthroscopy… Is it as benign as we think? 3. Minimal knee osteoarthritis on plain radiographs…setup for unexplained painful TKA? 4. Severe degenerative changes with flexion contracture and varus/valgus fixed deformity…is too much deformity a deterrent to outcome? Success 1. Patient Selection 2. Pre-operative optimization 3. Appropriate timing and management of patient expectations References 1. Brophy RH et al. Total knee arthroplasty after previous knee surgery: expected interval and the effect on patient age. J Bone Joint Surg Am. 2014 May 21;96(10):801-5 2. Mather RC et al. Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty. BMC Musculoskelet Disord. 2014 Jan 18;15:22 3. Bedair H et al. Economic benefit to society at large of total knee arthroplasty in younger patients: a Markov analysis. J Bone Joint Surg Am. 2014 Jan 15;96(2):119-26 4. Polkowski G et al. Is pain and dissatisfaction after TKA related to early-grade preoperative osteoarthritis? Clin Orthop Relat Res. 2013 Jan;471(1):162-8 5. American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis (OA) of the knee. Evidence-based Guideline. Ed 2. Rosemont, IL: American Academy of Orthopaedic Surgeons. Available from: http://www.aaos.org/research/guidelines/GuidelineOAKnee.asp. © 2016 The Knee Society 60 2:59 pm – 3:06 pm When Enough is Enough? Michael Ries, MD Failed two stage revision TKA for treatment of infection or multiply revised TKA’s with segmental bone loss can be reconstructed with a tumor prosthesis. However, larger amounts of segmental bone loss requiring replacement may be associated with greater areas of devascularized bone and soft tissue which could affect outcomes and complications. We reviewed our cases of non-oncologic femoral endoprosthetic reconstructions for revision TKA with distal femoral bone loss (n=22). Cases were categorized as distal femoral replacement (DIS) or diaphyseal femoral replacement (DIA) based on extension to or above the supracondylar metaphyseal-diaphyseal junction respectively. Infection free survival at 2 years (DIS=75% vs. DIA=20%) and 5 years (DIS=75% vs DIA=10%) was worse for larger endoprostheses. Larger endoprostheses had higher all cause reoperation rates (DIS=33% vs DIA=90%; p=0.012). Implant survival rates for longer reconstructions were worse at 2 years (DIS=100% vs. DIA=40%) and 5 years (DIS=90% vs. DIA=30%). Length of endoprosthesis did not affect ambulatory rates of patients at their most recent follow-up (DIS=72.7% vs. DIA=70%; p=1.000). Endoprosthetic replacement for the treatment of multiply failed TKA with segmental distal femoral bone loss proximal to the supracondylar metaphyseal-diaphyseal junction results in high infection and reoperation rates. Limb salvage remains possible with chronic antibiotic suppression. However, amputation may be a more viable option when bone loss in this patient population extends into the distal diaphysis. © 2016 The Knee Society 61 3:07 pm – 3:14 pm Periprosthetic Fractures about the Knee Bassam A. Masri, MD, FRCSC Introduction Fractures about a knee replacement are much less common that those about a hip replacement. They can occur intraoperatively, or more commonly post-operatively. Fractures of the femur, tibia and patella have been described, and will be discusses separately, both in the post-operative as well as the intra-operative setting. Post-operative fractures Femur Classification Fractures of the femur after a total knee arthroplasty usually occur in the supracondylar region. The authors’ recommended classification system was described by Lewis, Rorabeck, and Anglis. There are three types: Type I: Fracture undisplaced, component solidly fixed Type II: Fracture displaced, component solidly fixed Type III: Component loose, regardless of displacement of fracture Treatment Non-operative While traditionally this was the treatment of choice in the past, the morbidity of prolonged traction and bed rest is no longer justified, with the availability of safe and effective surgical techniques. Perhaps the only indication at present for non-operative treatment a Type I fracture in an elderly patient who is a poor surgical candidate. In the authors’ experience, these indications are very few. Operative Treatment Type I and II Type I and II fractures may be treated with internal fixation. The advent of locked plating has made treatment much more predictable and at present, intramedullary nailing is much less indicated. Type III If the implant is loose, it should be revised, regardless of the degree of displacement of the fracture. The fracture can be reduced and fixed with an intramedullary stem extension. It is important to bone graft these fractures, and to avoid cement intrusion into the fracture. Occasionally, there is so much comminution or bone loss due to osteopenia or osteolysis. In these cases, revision with an allograftprosthetic composite may be performed in younger patients. Alternatively, in older or in low demand patients, a tumor prosthesis can be used to replace the distal femur. This is the most common treatment option. © 2016 The Knee Society 62 Tibia Classification (Mayo Clinic Classification- adapted from Stuart MJ, Hanssen AD: Total knee arthroplasty: periprosthetic tibial fractures. Orthop Clin North Am 30(2):279-286, 1999) The Mayo Classification System takes into consideration the anatomic location (Types I-IV) as well as the status of fixation of the components and the time of injury (subcategory A, B, and C) Type I: Condylar Type II: Adjacent to stem Type III: Distal to stem Type IV: Tibial tubercle Subcategories: A: Prosthesis well fixed B: Prosthesis loose C: Intraoperative fracture Treatment Type I Type I fractures almost never occur without loosening of the tibial component, and therefore type IA fractures do not occur. The treatment of Type IB fractures is therefore revision total knee arthroplasty. The area of fracture has sufficient bone loss that simply internal fixation is rarely if ever sufficient. In most cases, revision with modular augments or bone graft for larger defects is required. As in most revision operations with poor bone stock, a stem is necessary. Type II Type IIA: These are about half as common as type IIB fractures, and occur as a result of significant trauma. Non-operative treatment with rigid immobilization is successful with no effect on knee function. Type IIB: These fractures are often related to massive osteolysis. They require revision arthroplasty with a long stem. Often, there is insufficient bone stock for a revision arthroplasty, and reconstruction with a structural allograft is often necessary. In older patients, a tumour prosthesis may be used to allow expedient rehabilitation. © 2016 The Knee Society 63 Type III Type IIIA: These fractures need to be treated independent of the knee replacement with open reduction and internal fixation, as the presence of a knee replacement precluded intramedullary nailing. Type IIIB: These are challenging fractures whose treatment needs to be individualized depending on the patient and the fracture. Occasionally, osteosynthesis to re-establish an intact tibia should be done initially, followed by revision total knee arthroplasty after fracture healing, if the fracture is well distal to the knee. If the fracture is proximal enough to be bypassed with a stem, revision arthroplasty with a long stem is the treatment of choice. Patella Classification (Goldberg et al, CORR 1988) Type I: Extensor mechanism intact, not extending to implant surface Type II: Extensor mechanism not intact, extending to implant surface Type III: Inferior pole fracture A: Patellar tendon rupture B: Patellar tendon intact Type IV: Fracture dislocation Treatment The treatment principles depend on the status of the extensor mechanism and on the status of fixation of the patellar component. If the extensor mechanism is intact, and the prosthesis is solidly fixed (type I), then non-operative treatment in a knee immobilizer should suffice. If the extensor mechanism is intact, but the patellar component is loose, the prosthesis can be removed if the remaining thickness of the patella does not allows resurfacing (less than 10 mm), or revised if the remaining thickness of the patella allows resurfacing (greater than 10 mm). If the extensor mechanism is not intact, the patellar component is often loose, except in Type III fractures. The extensor mechanism needs to be repaired in all cases. If the patellar remnant is too comminuted or does not allow resurfacing, then a patellectomy with soft tissue repair is indicated. © 2016 The Knee Society 64 3:15 pm – 3:22 pm Dealing with Extensor Mechanism Deficiency Matthew S. Austin, MD Extensor mechanism deficiency after total knee arthroplasty is rare, debilitating and associated with generally poor surgical outcomes [1-2]. Failure can occur both acutely and with chronic disease. Deficiency may occur within the quadriceps tendon, within the patella (secondary to fracture or osteonecrosis) or within the patellar tendon. Non-surgical management, using braces and walking aids, does not optimize patient function but may be a reasonable option in patients who are poor surgical candidates. Before considering surgical management, a thorough history and physical exam should be performed to assess for the chronicity of the injury, prior attempts at repair/reconstruction, medical comorbidities and the extent of disability. Diagnostic and imaging studies should be used to identify other concomitant issues including infection, implant failure, malalignment or fracture. Quadriceps tendon rupture may be repaired primarily through bone tunnels or suture anchors[3] or can be reconstructed with allograft reinforcement for more severe or chronic defects[1]. Primary repair of the patellar tendon has high complication rates and poor results as compared to repair in native knees. Reconstruction of the patellar tendon can be attempted in the acute setting with hamstring autograft[4] or bone patellar bone allograft[5]. In more chronic cases, especially when there is retraction of the patella, Achilles tendon allograft, whole extensor mechanism allograft[6] or synthetic mesh[7] are commonly used options. For cases that involve an anterior soft-tissue defect, a gastrocnemius flap reconstruction may be considered [8-9]. To date, there is no single method that reliably produces superior results. Although it is important to choose a suitable graft for a given case of extensor mechanism deficiency, multiple studies have shown that the technique of application, tensioning of the graft and the post-operative protocols such as casting are just as crucial[10][7]. In summary, extensor mechanism deficiency is a challenging surgical problem that requires careful patient selection and implementation of an appropriate reconstructive technique suitable for each patient. References [1] Dobbs RE, Hanssen AD, Lewallen DG, Pagnano MW. Quadriceps Tendon Rupture After Total Knee Arthroplasty. JBJS 2005;87-A. [2] Rand JA, Morrey, Bryan RS. Patellar Tendon Rupture After Total Knee Arthroplasty. Clin Orthop Relat Res 1987:233–8. © 2016 The Knee Society 65 [3] Kamath AF, Summers N, Israelite CL. Suture Anchor Repair of Patellar Tendon Rupture after Total Knee Arthroplasty. J Knee Surg 2013;26:128–31. doi:10.1016/j.arth.2011.01.006. [4] Cadambi A, Engh G a. Use of a semitendinosus tendon autogenous graft for rupture of the patellar ligament after total knee arthroplasty. A report of seven cases. JBJS 1992;74:974–9. [5] Zanotti RM, Freiberg A a., Matthews LS. Use of patellar allograft to reconstruct a patellar tendondeficient knee after total joint arthroplasty. J Arthroplasty 1995;10:271–4. doi:10.1016/S08835403(05)80173-1. [6] Brown NM, Murray T, Sporer SM, Wetters N, Berger RA, Valle CJ Della. Extensor Mechanism Allograft Reconstruction for Extensor Mechanism Failure Following Total Knee Arthroplasty. JBJS 2015;97:279–83. [7] Browne J a, Hanssen AD. Reconstruction of patellar tendon disruption after total knee arthroplasty: results of a new technique utilizing synthetic mesh. J Bone Joint Surg Am 2011;93:1137–43. doi:10.2106/JBJS.J.01036. [8] Jaureguito JW, Dubois CM, Smith SR, Gottlieb LJ, Finn H a. Medial gastrocnemius transposition flap for the treatment of disruption of the extensor mechanism after total knee arthroplasty. J Bone Joint Surg Am 1997;79:866–73. [9] Whiteside L a. Surgical technique: Muscle transfer restores extensor function after failed patellapatellar tendon allograft knee. Clin Orthop Relat Res 2014;472:218–26. doi:10.1007/s11999013-3101-9. [10] Nazarian B. Extensor mechanism allografts in total knee arthroplasty. Clin Orthop Relat Res 1999;367:123–9. © 2016 The Knee Society 66 3:23 pm – 3:30 pm Treatment of an Unstable Total Knee Replacement Robert T. Trousdale, MD Mayo Clinic, Rochester, MN I. Types of Instability 1. 2. 3. 4. Medial-lateral instability (varus-valgus) Symmetrical extension instability (recurvatum) Flexion instability Global instability II. Treatment 1. Principle: Use the least amount of constraint total knee that provides a well-balanced, stable knee in both extension-flexion and flexion. 2. Treatment of: a. Medial-lateral instability/varus-valgus instability: This is associated with significant preoperative deformity, asymmetrical bone resection, improperly balanced, or iantrogenic ligament injury. Treatment involves balancing the ligaments, occasional ligament reconstruction, increasing the constraint to an unlinked varus-valgus constraint (VVC) design versus a linked hinge. b. Recurvatum: This is associated with neuromuscular disease or excessive distal femoral resection. Treatment in most neuromuscular patients is usually a hinged component and in those that have iantrogenic distal femoral resection one can treat with a less constrained implant by building up the distal femur. c. Flexion instability: This is associated with an undersized femoral component, an increase in posterior tibial slope, failed posterior cruciate ligament, or under-resection of the distal femur resulting in utilization of a thinner polyethylene to give the patient full extension and be loose in flexion. Treatment involves upsizing the femoral component size to tighten the flexion space, occasionally increasing the distal femoral resection to get a thicker polyethylene in place, using a posterior stabilized knee or a VVC knee if needed. d. Global instability: This is associated with a combination of the above ligament deficiencies. This often requires increasing constraint to a VVC or a hinged component © 2016 The Knee Society 67 3:31 pm – 3:38 pm Diagnosis of Prosthetic Knee Joint Infection Kevin L. Garvin, MD University of Nebraska Medical Center Prosthetic knee joint infection has emerged as one of the most common causes of a failed total knee arthroplasty. While the presentation of infection may be obvious, it also may be elusive for even the most skilled diagnosticians who struggle to make the correct diagnosis and identify the offending pathogen. The first step along the path of diagnosis is recognizing the signs and symptoms associated with a prosthetic joint infection. Whether the patient has a draining sinus or the insidious onset of pain and stiffness, the evaluation must be thorough beginning with the patient’s history, examination, radiographs and then continuing with serum studies of inflammation (CRP, ESR). If the laboratory values are elevated or the surgeon has a high suspicion of infection, then joint aspiration is recommended. The fluid is analyzed for white blood cell count, differential (looking for neutrophils) and then cultured. Chronic versus acute infections have different thresholds for the number of cells (3-4,000 cells/μL vs. 10,000 cells/μL) and the percent of neutrophils (60-80% vs. 90%). Nuclear imaging has a limited role in the diagnosis. Intraoperative evaluation of the patient is also essential including repeat aspiration, frozen section analysis of the tissue, and culture of the fluid and tissue. When a stepwise algorithm for the possibility or probability of infection is followed the diagnosis of infection can be established for the majority of patients. Because a single test for the diagnosis of infection does not exist, objective criteria established by the Musculoskeletal Infection Society (MSIS) aids in the diagnosis. The more challenging diagnosis may be aided by newer diagnostic tests such as alpha defensin or enhanced culture techniques, sonication of the knee implant, and holding cultures for up to three weeks to allow slow-growing organisms to be identified. It is possible that the diagnosis of infection is correct but the culture fails to identify a pathogen. This diagnostic dilemma can occur in 7-12% of prosthetic joint infections. Limited evidence supports treating these patients like patients with known bacteria including a two-stage reimplantation and 4-6 weeks of parenteral antibiotics as directed by the infectious disease specialists. In summary, the diagnosis of a prosthetic knee infection requires a disciplined approach using wellestablished criteria. New diagnostic tests and techniques may prove to be helpful in situations when the diagnosis is elusive. References 1. 2. American Academy of Orthopaedic Surgeons. The diagnosis of periprosthetic joint infections of the hip and knee: Guideline and evidence report. Adopted by the AAOS board of directors. Chicago, IL: American Academy of Orthopaedic Surgeons; 2010. Available from: http://www.aaos.org/cc_files/aaosorg/research/guidelines/pjiguideline.pdf. Accessed December 15, 2015. Bedair H, Ting N, Jacovides C, Saxena A, Moric M, Parvizi J, Della Valle CJ. The mark coventry award: Diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res. 2011;469:34-40. © 2016 The Knee Society 68 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, Steckelberg J, Osmon D. Inflammatory blood laboratory levels as markers of prosthetic joint infection: A systematic review and meta-analysis. J Bone Joint Surg Am. 2010;92:2102-2109. Boot W, Moojen DJ, Visser E, Lehr AM, De Windt TS, Van Hellemondt G, Geurts J, Tulp NJ, Schreurs BW, Burger BJ, Dhert WJ, Gawlitta D, Vogely HC. Missed low-grade infection in suspected aseptic loosening has no consequences for the survival of total hip arthroplasty. Acta Orthop. 2015;86:678-683. Chalmers PN, Walton D, Sporer SM, Levine BR. Evaluation of the role for synovial aspiration in the diagnosis of aseptic loosening after total knee arthroplasty. J Bone Joint Surg Am. 2015;97:1597-1603. Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Combined measurement of synovial fluid alpha-defensin and C-reactive protein levels: Highly accurate for diagnosing periprosthetic joint infection. J Bone Joint Surg Am. 2014;96:1439-1445. Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254-3262. Di Cesare PE, Chang E, Preston CF, Liu CJ. Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty. J Bone Joint Surg Am. 2005;87:1921-1927. Dinneen A, Guyot A, Clements J, Bradley N. Synovial fluid white cell and differential count in the diagnosis or exclusion of prosthetic joint infection. Bone Joint J. 2013;95-B:554-557. Greidanus NV, Masri BA, Garbuz DS, Wilson SD, McAlinden MG, Xu M, Duncan CP. Use of erythrocyte sedimentation rate and C-reactive protein level to diagnose infection before revision total knee arthroplasty. A prospective evaluation. J Bone Joint Surg Am. 2007;89:1409-1416. Janz V, Wassilew GI, Hasart O, Tohtz S, Perka C. Improvement in the detection rate of PJI in total hip arthroplasty through multiple sonicate fluid cultures. J Orthop Res. 2013;31:20212024. Johnson AJ, Zywiel MG, Stroh DA, Marker DR, Mont MA. Should gram stains have a role in diagnosing hip arthroplasty infections? Clin Orthop Relat Res. 2010;468:2387-2391. Martinez-Pastor JC, Macule-Beneyto F, Suso-Vergara S. Acute infection in total knee arthroplasty: Diagnosis and treatment. Open Orthop J. 2013;7:197-204. Oethinger M, Warner DK, Schindler SA, Kobayashi H, Bauer TW. Diagnosing periprosthetic infection: False-positive intraoperative gram stains. Clin Orthop Relat Res. 2011;469:954-960. Omar M, Ettinger M, Reichling M, Petri M, Guenther D, Gehrke T, Krettek C, Mommsen P. Synovial C-reactive protein as a marker for chronic periprosthetic infection in total hip arthroplasty. Bone Joint J. 2015;97-B:173-176. Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR, Infectious Diseases Society of America. Diagnosis and management of prosthetic joint infection: Clinical practice guidelines by the infectious diseases society of america. Clin Infect Dis. 2013;56:e1-e25. Parvizi J, Jacovides C, Antoci V, Ghanem E. Diagnosis of periprosthetic joint infection: The utility of a simple yet unappreciated enzyme. J Bone Joint Surg Am. 2011;93:2242-2248. Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG. New definition for periprosthetic joint infection: From the workgroup of the musculoskeletal infection society. Clin Orthop Relat Res. 2011;469:29922994. Portillo ME, Salvado M, Alier A, Martinez S, Sorli L, Horcajada JP, Puig L. Advantages of sonication fluid culture for the diagnosis of prosthetic joint infection. J Infect. 2014;69:35-41. © 2016 The Knee Society 69 20. Qu X, Zhai Z, Liu X, Li H, Wu C, Li Y, Li H, Zhu Z, Qin A, Dai K. Evaluation of white cell count and differential in synovial fluid for diagnosing infections after total hip or knee arthroplasty. PLoS One. 2014;9:e84751-e84751. 21. Randau TM, Friedrich MJ, Wimmer MD, Reichert B, Kuberra D, Stoffel-Wagner B, Limmer A, Wirtz DC, Gravius S. Interleukin-6 in serum and in synovial fluid enhances the differentiation between periprosthetic joint infection and aseptic loosening. PLoS One. 2014;9:e89045. 22. Schwarzkopf R, Carlson EM, Tibbo ME, Josephs L, Scott RD. Synovial fluid differential cell count in wear debris synovitis after total knee replacement. Knee. 2014;21:1023-1028. 23. Shafafy R, McClatchie W, Chettiar K, Gill K, Hargrove R, Sturridge S, Guyot A. Use of leucocyte esterase reagent strips in the diagnosis or exclusion of prosthetic joint infection. Bone Joint J. 2015;97-B:1232-1236. 24. Shah NB, Tande AJ, Patel R, Berbari EF. Anaerobic prosthetic joint infection. Anaerobe. 2015;36:1-8. 25. Tetreault MW, Wetters NG, Moric M, Gross CE, Della Valle CJ. Is synovial C-reactive protein a useful marker for periprosthetic joint infection? Clin Orthop Relat Res. 2014;472:3997-4003. 26. Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ. Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty. 2012;27:811. 27. Yi PH, Cross MB, Moric M, Sporer SM, Berger RA, Della Valle CJ. The 2013 frank stinchfield award: Diagnosis of infection in the early postoperative period after total hip arthroplasty. Clin Orthop Relat Res. 2014;472:424-429. © 2016 The Knee Society 70 3:39 pm – 3:46 pm Patient is Unhappy, But I Don't Know Why Robert L. Barrack, MD Washington University School of Medicine There is growing evidence to suggest many patients experience pain and dissatisfaction after TKA in spite of implants that appear to be adequately implanted. Important factors to consider other than the implant design and surgical technique include patient expectations, certain patient characteristics (both physical and psychological) and the degree of preoperative degenerative arthritis. In a recent study the relationship between early-grade preoperative OA with pain and dissatisfaction after TKA was examined. [1] We evaluated all (n = 49) painful TKAs in a 1-year period that had no evidence of loosening, instability, malalignment, infection, or extensor mechanism dysfunction and classified the degree of preoperative OA according to the scale of Kellgren and Lawrence. For comparison, we identified three other cohorts of TKAs from the same center and classified their preoperative grade of OA: Group B (n = 100) was a consecutive series of primary TKAs performed for OA during the same year; Group C (n = 80) were asymptomatic TKAs from 1 to 4 years postoperatively; and Group D (n = 80) were TKAs with some degree of pain at 1 to 4 years postoperatively. Patients in Group A had a higher incidence of early-grade OA is preoperatively (49%) compared with any of the comparison groups: Group B, (5%); Group C, (6%); and Group D, (10%). In another study, a surprisingly high incidence of persistent symptoms was identified in a large group of TKA patients from total joint centers when questioned anonymously by a third party interviewer. [2] A high percentage of patients referred for unexplained pain after TKA had early-grade osteoarthritis preoperatively. Patients undergoing TKA for less than Grade 3 or 4 OA should be informed that they may be at higher risk for persistent pain and dissatisfaction. Other major factors predisposing to dissatisfaction include unmet expectations and one of a number of preoperative patient characteristics. [3] Although these patient factors may not constitute a contraindication to TKA, these potential surgical candidacy should be informed that they are potentially at a higher risk for persistent symptoms and dissatisfaction. Since unmet expectations are the strongest predictor of dissatisfaction following TKA, realistic informed consent regarding TKA outcomes is critical. [4] References 1. Polkowski, G. G., 2nd, et al. (2013). "Is pain and dissatisfaction after TKA related to earlygrade preoperative osteoarthritis?" Clin Orthop Relat Res 471(1): 162-168. 2. Parvizi, J., et al. (2014). "High level of residual symptoms in young patients after total knee arthroplasty." Clin Orthop Relat Res 472(1): 133-137. 3. Bourne, R. B., et al. (2010). "Patient satisfaction after total knee arthroplasty: who is satisfied and who is not?" Clin Orthop Relat Res 468(1): 57-63. 4. Husain, A. and G. C. Lee (2015). "Establishing Realistic Patient Expectations Following Total Knee Arthroplasty." J Am Acad Orthop Surg 23(12): 707-713. © 2016 The Knee Society 71 Session VIII: The Young Investigator Symposium 4:07 pm – 4:12 pm Paper 1 Closed Incision Negative Pressure Therapy Versus Antimicrobial Dressings Following Revision Hip and Knee Surgery: A Comparative Study H. John Cooper, MD Marcel A. Bas, MD Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, NY Introduction Wound complications and surgical site infections (SSIs) following revision hip and knee surgery are a major source of patient morbidity and represent a substantial healthcare burden. Despite improved infection control practices, SSI prevention remains an important clinical challenge and demands innovative interventions. This study assesses the effect of closed incision negative pressure therapy (ciNWT) on rates of wound complications and surgical site infections (SSIs) following revision hip and knee surgery. Methods A retrospective quality improvement analysis of 141 consecutive revision hip and knee operations performed by a single surgeon over a 34-month period was conducted. Preoperative SSI prevention measures were standardized across the cohort. Closed incision NPT was used selectively in higherrisk patients with multiple risk factors for SSI over the last 15 months of the study period. Rates of wound complications, SSIs, and reoperation through the first 90 days were compared with patients treated with a sterile antimicrobial dressing (AQUACEL® Ag), which represents the standard-of-care at our institution. Results Three patients were lost to follow-up prior to final outcome, leaving 138 patients (97.9%) available for analysis. Antimicrobial dressings were used in 108 patients, whereas ciNPT was used in 30 patients. Patients treated with ciNPT developed fewer overall wound complications (6.7% vs. 26.9%, P = 0.032) and fewer total SSIs (3.3% vs. 18.5%, P = 0.045) compared with patients treated with antimicrobial dressings. Additionally, there were trends toward a lower rate of superficial wound dehiscence (6.7% vs. 19.4%, P = 0.163), fewer deep periprosthetic joint infections (0.0% vs. 9.3%, P = 0.118), and fewer reoperations (3.3% vs. 13.0%, P = 0.191) among patients treated with ciNPT. Discussion/Conclusion Our findings suggest that ciNPT decreases the incidence of wound complications and SSIs in patients undergoing revision hip and knee surgery, and may have potential for lowering the rate of reoperation in this patient population. © 2016 The Knee Society 72 4:13 pm – 4:18 pm Paper 2 Discharge Destination after Total Knee Arthroplasty: An Analysis of Post-Discharge Outcomes and Risk Factors Calin S. Moucha, MD; Aakash Keswani Background This study aimed to compare risk of post-discharge adverse events in elective total knee arthroplasty (TKA) patients by discharge destination, identify risk factors for inpatient discharge placement and post-discharge adverse events, and stratify TKA patients based on these risk factors to identify the most appropriate discharge destination. Methods Patients that underwent elective primary TKA from 2011-2014 were identified in the NSQIP database. Bivariate and multivariate analyses were performed on perioperative variables. Results 100,275 TKA patients were analyzed. The most common discharge destinations included home (70%), skilled nursing facility (SNF) (19%), and inpatient rehabilitation facility (IRF) (11%). Bivariate analysis revealed that rates of post-discharge adverse events were higher in SNF and IRF patients (p≤0.001). In multivariate analysis, SNF and IRF patients were more likely to have post-discharge severe adverse events (SNF: OR 1.38, p≤0.001; IRF: OR 1.30, p≤0.001) and unplanned readmission (SNF: OR 1.45, p≤0.001; IRF: OR 1.40, p≤0.001) (Table 1). After stratifying patients by strongest independent risk factors (OR ≥1.10, p≤0.05) for adverse outcomes post-discharge, we found that home discharge is the optimal strategy for minimizing rate of unplanned 30-day readmissions (p≤0.05 for 5 out of 6 risk levels) and severe 30-day adverse events post-discharge (p≤0.05 for 3 out of 6 risk levels) (Table 2). Conclusion SNF or IRF discharge increases risk of post-discharge adverse events compared to home. Modifiable risk factors for non-home discharge and post-discharge adverse events should be addressed pre-operatively to improve patient outcomes across discharge settings. © 2016 The Knee Society 73 Table 1. Risk factors for severe adverse events post-discharge and unplanned readmission Outcome/Risk Factor Odds ratio (95% CI) Severe adverse event post-discharge Severe adverse event pre-discharge 2.29 (1.65-3.20) Rehab discharge destination 1.30 (1.10-1.53) SNF discharge destination 1.38 (1.21-1.58) Operative time 1.003 (1.002-1.004) Male gender 1.50 (1.34-1.67) Functional status 1.74 (1.27-2.38) BMI>40 1.30 (1.13-1.51) History of smoking 1.46 (1.23-1.73) Pulmonary disease 1.27 (1.01-1.60) Hypertension 1.25 (1.10-1.42) Renal disease 3.12 (1.63-5.98) Steroids for chronic condition within 30 days of procedure 1.71 (1.37-2.14) Bleeding-causing disorder 1.77 (1.40-2.24) ASA class ¾ 1.39 (1.23-1.56) General anesthesia 1.14 (1.02-1.27) Unplanned 30-day readmission Severe adverse event pre-discharge 2.80 (2.28-3.44) Rehab discharge destination 1.40 (1.26-1.55) SNF discharge destination 1.45 (1.33-1.58) Age 1.02 (1.01-1.02) Operative time 1.002 (1.001-1.003) Male gender 1.34 (1.25-1.44) Functional status 1.37 (1.09-1.72) BMI>40 1.14 (1.03-1.26) History of smoking 1.31 (1.16-1.48) Pulmonary disease 1.54 (1.34-1.78) Cardiac disease 1.28 (1.14-1.43) Hypertension 1.30 (1.14-1.43) Renal disease 3.11 (1.98-4.90) Steroids for chronic condition within 30 days of procedure 1.38 (1.17-1.61) Bleeding-causing disorder 1.71 (1.46-2.00) ASA class ¾ 1.44 (1.33-1.56) © 2016 The Knee Society 74 p-value <0.001 0.002 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 0.04 <0.001 <0.001 0.003 <0.001 <0.001 0.02 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 0.007 0.01 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 4:19 pm – 4:24 pm Paper 3 Thrombogenic Risk of Unicompartmental Knee Versus Total Knee Replacement Edwin P. Su, MD; Lauren E. Mount, MD; Allina Nocon, MPH; Thomas P. Sculco, MD; George Go, BS; Nigel E. Sharrock, BMedSci, MB, ChB Introduction The relative thrombogenic risk of unicompartmental knee replacement (UKR) compared to total knee replacement (TKR) is unknown. This is important as it could provide a basis for DVT prophylaxis. We looked at the association between procedure and time on circulating markers of thrombin generation, thrombin-anti-thrombin complex (TAT), pro-thrombin F1+2 (F1+2), and Interleukin-6 (IL-6), a pro-inflammatory cytokine. Patients and methods Following IRB approval, 75 patients undergoing unilateral TKR (n=25), UKR (n=25), or bilateral one staged TKR (n=25), were studied. Inclusion criteria included: age 19 to 80; osteoarthritis or avascular necrosis and surgery performed under tourniquet using combined spinal epidural anesthesia. Patients were excluded if they had been on anticoagulation therapy prior to undergoing surgery or had inflammatory arthritis or other inflammatory states. Blood samples were collected from a radial artery catheter at 4 time points during surgery: 1) post anesthesia induction, 2) immediately following incision with the tourniquet inflated, 3) with tourniquet release, and 4) at wound closure. Samples were immediately stored in ice, centrifuged, and frozen at -20 Celsius. TAT and F1+2, were measured using ELISA assays. The generalized estimating equations approach was used to assess the effect of procedure (unicompartmental, unilateral TKR, and bilateral TKR) and time (1, 2, 3, and 4), on (1) TAT, (2) F1+2, and IL-6. Pairwise comparisons were done by procedure to investigate the interaction between procedure and time. Predictors of IL-6 elevation were assessed in the same fashion. In assessing the relationship between tourniquet time (TT) and change in IL-6 level, times 2 and 3 were chosen. A Spearman’s Correlation Coefficient was done to examine the relationship between TT time and change in IL-6 level between Time 2 and 3. A pvalue less that <0.05 was considered significant. Results TAT increased throughout surgery (p<0.001) in all three groups. There was no difference in the magnitude of the increase in either TAT or F1+2 between the different procedures. A significant interaction was found between time and procedure for F1+2; p=0.01. A difference between Time 2 and 3 was found only for those who had a bilateral total knee procedure; p<0.001. There was a significant increase in IL-6 throughout surgery (p<0.001). The largest increase was noted with one staged bilateral TKR and there was minimal increase with UKR. , A difference was found between © 2016 The Knee Society 75 procedure (p=0.003) and time (p=<0.001)). The strongest relationship between TT and change in IL-6 level were in patients undergoing a UKR procedure; r=0.60, p=0.009. After adjustment for all other predictors; BMI (p=0.05), ASA class (p=0.02), race (p=0.002), tourniquet time (p=0.02), and having a bilateral knee replacement (p=0.01) were found to be predictors of IL-6 elevation. Conclusion There is a significant activation of thrombosis during UKR. Surprisingly, this appears of similar magnitude to TKR. This suggests that patients undergoing UKR require thromboprophylaxis to the same degree as patients undergoing TKR, from a surgical standpoint. However, a patient with UKR mobilizes more quickly postoperatively and could mitigate this finding. Future studies are needed to further explore the interaction between procedure and time, specifically for F1+2. IL-6 levels vary according to procedure and time points of surgery. In patients undergoing UKR, a more limited intervention, we observed a minimal rise in IL-6 throughout surgery. However, the strong relationship between TT and change in IL-6 levels between time point 2 and 3 in UKR suggest strong monitoring of TT can be of benefit to the patient. © 2016 The Knee Society 76 Session IX: Transitioning to Outpatient TKA 4:36 pm – 4:43 pm Building an Outpatient TKA Program Keith R. Berend, MD To progress to a same day surgery program for arthroplasty, it is important that we examine and resolve the issues of why patients stay in the hospital. The number one reason is fear and anxiety of the unknown and of surgical pain. The need for hospital stay is also related to risk arising from co-morbidities and medical complications. Patients also need an extended stay to manage the side effects of our treatment, including after effects of narcotics and anesthesia, blood loss, and surgical trauma. The process begins preoperatively with an appropriate orthopaedic assessment of the patient and determination of the need for surgery. The orthopaedic team must motivate the patient, and ensure that the expectations of the patient, family and surgeon are aligned. In conjunction with our affiliated hospitalist group that performs almost all pre-admission testing, we have established guidelines for patient selection for outpatient arthroplasty. The outpatient surgical candidate must have failed conservative measures, must have appropriate insurance coverage, and must be functionally independent. Previous or ongoing comorbidities that cannot be optimized for safe outpatient care may include: congestive heart failure, or valve disease; chronic obstructive pulmonary disease, or home use of supplemental oxygen; untreated obstructive sleep apnea with a BMI >40 kg/m2; hemodialysis or severely elevated serum creatinine; anemia with hemoglobin <13.0 g/dl; cerebrovascular accident or history of delirium or dementia; and solid organ transplant. Pre-arthroplasty rehabilitation prepares the patient for perioperative protocols. Patients meet with a physical therapist and are provided with extensive educational materials before surgery to learn the exercises they will need for functional recovery. Enhancement of our perioperative pain management protocols has resulted in accelerated rehabilitation. The operative intervention must be smooth and efficient, but not hurried. Less invasive approaches and techniques have been shown to decrease pain, reduce length of stay, and improve outcomes, especially in the short term. Between June 2013 and December 2015, 1957 primary knee arthroplasty procedures (1010 total, 947 partial) were performed by the author and his 3 associates at an outpatient surgery center. Seven percent of patients required an overnight stay, with a majority for reasons of convenience related to travel distance or later operative time. Importantly, no one has required overnight stay for pain management. Outpatient arthroplasty is safe, it’s better for us and our patients, and it is here now. In an outpatient environment the surgeon actually spends more time with the patients and family in a friendly environment. Patients feel safe and well cared for, and are highly satisfied with their arthroplasty experience. 1. Berger RA, Kusuma SK, Sanders SA, Thill ES, Sporer SM. The feasibility and perioperative complications of outpatient knee arthroplasty. Clin Orthop Relat Res. 2009;467(6):1443-9. 2. Kolisek FR, McGrath MS, Jessup NM, Monesmith EA, Mont MA. Comparison of outpatient versus inpatient total knee arthroplasty. Clin Orthop Relat Res. 2009;467(6):1438-42. 3. Lovald ST, Ong KL, Malkani AL, Lau EC, Schmier JK, Kurtz SM, Manley MT. Complications, mortality, and costs for outpatient and short-stay total knee arthroplasty patients in comparison to standard-stay patients. J Arthroplasty. 2014;29(3):510-5. © 2016 The Knee Society 77 4:44 pm – 4:51 pm Outpatient TKA: A Triumph of Knowledge over Reason Bryan D. Springer, MD With a shift in health care to value over volume and a surge in physician owned surgery centers, there is an increasing interest in performing outpatient total joint arthroplasty. The exact role and benefit to the patient in this venture has yet to be firmly elucidated. As we see an increasing push from surgeons and centers to perform outpatient total joint arthroplasty we must ask first and foremost what are the risk and benefits to the patients and what are the financial implications in this current health care model. Outpatient total knee arthroplasty most certainly be done safely, but not in everyone. Several studies have demonstrated that major cardiac events and fatal or near fatal complications occur on postoperative two1-3. The study by Parvizi et al determined that nearly 60% of patients that had fatal or near-fatal complications had no identifiable predisposing risk factors. Patient selection remains the key to building a successful outpatient total joint program3. Courtney et al identified CHF, COPD, Coronary disease and Cirrhosis as independent risk factors for complications identified these co-morbidities in patients that should not undergo outpatient or short stay total joint arthroplasty4. Outpatient total knee arthroplasty also has the potential to threaten our reimbursement for TJA. In addition, with an emphasis being placed on prevention of readmission, a poorly selected patient population for outpatient TKA may lead to financial penalties. Reimbursement of TJA is determined by RUC valuations, a combination of minutes work, practice expense and malpractice costs. A shift to outpatient TJA will only serve to lower the RUC valuation (minutes worked) and ultimately lower out already diminishing reimbursement. Currently, Medicare penalized hospitals 3% for excessive readmission following TJA, with increasing penalties expected. An internal review of our data showed nearly double the readmission rate for outpatient TKA compared to 1-2 days inpatient stay5. Outpatient total knee arthroplasty can be done safely but requires meticulous patient selections, preoperative optimization and postoperative in-home support6. Before wide expansion of outpatient total knee arthroplasty, more studies need to be done to identify proper patient selection, optimum protocols, readmission prevention and financial implications to all total joint surgeons. 1. 2. Belmont PJ, Goodman GP, Kusnezov NA, et al. Postoperative myocardial infarction and cardiac arrest following primary total knee and hip arthroplasty: Rates, risk factors, and time of occurrence. The Journal of Bone & Joint Surgery. 2014;96(24):2025-2031. Lalmohamed A, Vestergaard P, Klop C, et al. Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study. Archives of internal medicine. 2012;172(16):1229-1235. © 2016 The Knee Society 78 3. 4. 5. 6. Parvizi J, Mui A, Purtill JJ, Sharkey PF, Hozack WJ, Rothman RH. Total joint arthroplasty: when do fatal or near-fatal complications occur? The Journal of Bone & Joint Surgery. 2007;89(1):27-32. Courtney PM, Rozell JC, Melnic CM, Lee G-C. Who Should Not Undergo Short Stay Hip and Knee Arthroplasty? Risk Factors Associated with Major Medical Complications Following Primary Total Joint Arthroplasty. The Journal of Arthroplasty. 2015. Vegari D, Mokris J, Odum S, Springer B. Implications of outpatient vs. inpatient total joint arthroplasty on hospital readmission rate. Paper 367. Paper presented at: annual meeting of the American Academy of Orthopaedic Surgeons2014. Lovald S, Ong K, Lau E, Joshi G, Kurtz S, Malkani A. Patient selection in outpatient and shortstay total knee arthroplasty. Journal of surgical orthopaedic advances. 2013;23(1):2-8. © 2016 The Knee Society 79 CME ACCREDITATION STATEMENT This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the American Academy of Orthopaedic Surgeons and the Knee Society. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians. CREDIT HOURS The American Academy of Orthopaedic Surgeons designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Upon completion of this activity, participants will be able to: • Update clinical skills and basic knowledge through research findings and biomechanical studies. • Discuss the various surgical and non-surgical treatments and management of conditions related to the knee joint. • Determine indications and complications in total knee arthroplasty. • Critique presentations of surgical techniques and demonstrations of treatment options. • Evaluate the efficacy of new treatment options through evidence-based data. FDA STATEMENT Some pharmaceuticals and/or medical devices at the Specialty Day Meeting have not been cleared by the U.S. Food and Drug Administration (FDA) or have been cleared by the FDA for specific purposes only. The FDA has stated that it is the responsibility of the physician to determine the FDA status of each pharmaceuticals and/or medical devices he or she wishes to use in clinical practice. The Knee Society policy provides that “off label” uses of a device or pharmaceutical may be described in The Knee Society’s CME activities so long as the “off-label” status of the device or pharmaceutical is also specifically disclosed (i.e. that the FDA has not approved labeling the device for the described purpose). Any device or pharmaceutical is being used “off label” if the described use is not set forth on the product’s approved label. To obtain information regarding the clearance status of a device or pharmaceutical refers to the product labeling or call the FDA at 1-800-638-2041 or visit the FDA internet site at http://www.fda.gov/cdrh/510khome.html FINANCIAL DISCLOSURE Each participant in The Knee Society Specialty Day Meeting has been asked to disclose if he or she has received something of value from a commercial company, which relates directly or indirectly to the subject of their presentation. The Knee Society does not view the existence of these interests or commitments as necessarily implying bias or decreasing the value of the author’s participation in the 2016 The Knee Society Specialty Day Meeting. THE KNEE SOCIETY EDUCATION COMMITTEE: Kevin John Bozic, MD, MBA, Chair: Submitted on: 11/09/2015; AAOS: Board or committee member; American Joint Replacement Registry: Board or committee member; Harvard Business School: Paid consultant; Institute for Healthcare Improvement: Paid consultant; Orthopaedic Research and Education Foundation: Board or committee member; Yale-New Haven Center for Outcomes Research: Paid consultant Keith R Berend, MD: Submitted on: 10/12/2015; AAOS Board of Specialty Societies (Knee Education Representative): Board or committee member; American Association of Hip and Knee Surgeons: Board or committee member; Clinical Orthopaedics and Related Research: Editorial or governing board; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Kinamed: Research support; Knee Society: Board or committee member; Orthopedics: Editorial or governing board; Orthosensor: Research support; Pacira: Research support; Reconstructive Review: Editorial or governing board; Zimmer Biomet: IP royalties; Paid consultant; Research support William L Griffin, MD: Submitted on: 10/12/2015; American Association of Hip and Knee Surgeons: Board or committee member; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Paid presenter or speaker; Research support; Journal of Arthroplasty, CORR: Editorial or governing board; Knee Society, AAOS: Board or committee member Zimmer: Research support © 2016 The Knee Society 80 Stephen J Incavo, MD: Submitted on: 01/26/2016; Biomet: IP royalties; Innomed: IP royalties; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Smith & Nephew: IP royalties; Wright Medical Technology, Inc.: IP royalties; Zimmer: IP royalties; Paid consultant; Stock or stock Options R Michael Meneghini, MD: Submitted on: 09/29/2015; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Stryker: IP royalties; Paid consultant; Research support Timothy M Wright, PhD: Submitted on: 10/30/2015; Exactech, Inc: IP royalties; Stock or stock Options; Knee Society: Board or committee member; Lima: IP royalties; Mathys Ltd: IP royalties; Orthobond: Stock or stock Options; Stryker: Research support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Publishing royalties, financial or material support; Zimmer: Paid consultant PRESENTERS AND MODERATORS Matthew Austin, MD: Submitted on: 12/15/2015; AAOS: Board or committee member; American Association of Hip and Knee Surgeons: Board or committee member; JayPee: Publishing royalties, financial or material support Journal of Arthroplasty: Editorial or governing board; Link Orthopaedics: Paid consultant; Zimmer: IP royalties; Paid consultant David Christopher Ayers, MD: Submitted on: 10/01/2015; AAOS: Board or committee member; American Orthopaedic Association: Board or committee member; Journal of Bone and Joint Surgery - American: Editorial or governing board C Lowry Barnes, MD: Submitted on: 01/21/2016; American Association of Hip and Knee Surgeons: Board or committee member; AR Orthopaedic Society: Board or committee member; Clinical Orthopaedics and Related Research: Editorial or governing board; ConforMIS: Research support; Corin U.S.A.: Other financial or material support; DJO: IP royalties; Paid consultant; HipKnee Arkansas Foundation: Board or committee member; Journal of Arthroplasty: Editorial or governing board; JSOA: Editorial or governing board; Liventa: Research support; Stock or stock Options; Mid American Orthopaedic Association: Board or committee member; None: Unpaid consultant; Pacira: Research support; Responsive Orthopaedics: Stock or stock Options; Southern Orthopaedic Association: Board or committee member; Zimmer: IP royalties; Paid consultant Robert L Barrack, MD: Submitted on: 10/26/2015; Biomet: Research support; Hip Society: Board or committee member; Journal of Bone and Joint Surgery - American: Editorial or governing board; Journal of Bone and Joint Surgery - British: Editorial or governing board; Knee Society: Board or committee member; Medical Compression Systems: Research support; National Institutes of Health (NIAMS & NICHD): Research support; Smith & Nephew: Research support; Stryker: IP royalties; Other financial or material support; Paid consultant; Research support; The McGraw-Hill Companies Inc: Publishing royalties, financial or material support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Publishing royalties, financial or material support; Wright Medical Technology, Inc.: Research support Wael K Barsoum, MD: Submitted on: 10/01/2015; Active Implants: Research support; Cool Systems: Research support; Custom Orthopaedic Solutions: Stock or stock Options; DJO, Inc.: Research support; Exactech, Inc: IP royalties; iVHR: Stock or stock Options; KEF Healthcare (Board Member): Other financial or material support Orthosensor: Research support; Orthovita: Research support; Otismed: Stock or stock Options; Stryker: IP royalties; Paid consultant; Paid presenter or speaker; Research support; Zimmer: IP royalties; Research support Marcel A Bas, MD: (This individual reported nothing to disclose); Submitted on: 11/12/2015 Ali Bayan, FRACS: Submitted on: 01/27/2016; Lima: Paid consultant; Paid presenter or speaker Nicholas Bedard, MD: (This individual reported nothing to disclose); Submitted on: 01/27/2016 Keith R Berend, MD: Submitted on: 10/12/2015; AAOS Board of Specialty Societies (Knee Education Representative): Board or committee member; American Association of Hip and Knee Surgeons: Board or committee member; Clinical Orthopaedics and Related Research: Editorial or governing board; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Kinamed: Research support; Knee Society: Board or committee member; Orthopedics: Editorial or governing board; Orthosensor: Research support; Pacira: Research support; Reconstructive Review: Editorial or governing board; Zimmer Biomet: IP royalties; Paid consultant; Research support Michael E Berend, MD: Submitted on: 02/02/2016; Biomet: IP royalties; Paid consultant; Paid presenter or speaker; Research support; Johnson & Johnson. Into our 501c3 research foundation: Research support; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Stryker: Research support; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Research support Daniel J Berry, MD: Submitted on: 10/12/2015; American Joint Replacement Registry: Board or committee member; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Research support; Elsevier: Publishing royalties, © 2016 The Knee Society 81 financial or material support; Hip Society: Board or committee member; Journal of Bone and Joint Surgery - American: Editorial or governing board; Mayo Clinic Board of Governors: Board or committee member; Wolters Kluwer Health Lippincott Williams & Wilkins: Publishing royalties, financial or material support Michael Bolognesi, MD: Submitted on: 10/01/2015; Amedica: Stock or stock Options; Unpaid consultant; American Association of Hip and Knee Surgeons: Board or committee member; AOA Omega: Other financial or material support; Arthroplasty Today: Editorial or governing board; Biomet: IP royalties; Paid presenter or speaker; Research support; DePuy, A Johnson & Johnson Company: Research support; Eastern Orthopaedic Association: Board or committee member; Journal of Arthroplasty: Editorial or governing board; Journal of Surgical Orthopaedic Advances: Editorial or governing board; Kinamed: Paid presenter or speaker; TJO: IP royalties; Paid consultant; Stock or stock Options; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Research support Robert E Booth, Jr MD: Submitted on: 01/28/2016; CD Diagnostics: Stock or stock Options; Journal of Bone and Joint Surgery - American: Editorial or governing board; Journal of Bone and Joint Surgery - AmericanClinical Orthopaedics & Related Research: Editorial or governing board; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Stock or stock Options Kevin John Bozic, MD, MBA: Submitted on: 11/09/2015; AAOS: Board or committee member; American Joint Replacement Registry: Board or committee member; Harvard Business School: Paid consultant; Institute for Healthcare Improvement: Paid consultant; Orthopaedic Research and Education Foundation: Board or committee member; Yale-New Haven Center for Outcomes Research: Paid consultant Toby Briant-Evans, FRCS: (This individual reported nothing to disclose); Submitted on: 01/27/2016 Asokumar Buvanendran, MD: Submitted on: 01/26/2016; American Society of Regional Anesthesia and Pain Medicine: Board or committee member; Anesthesia & AnalgesiaRegional Anesthesia and Pain Medicine: Editorial or governing board; consultant about multimodal analgesia: Paid consultant; Pfizer: Research support; vital 5: Stock or stock Options John J Callaghan, MD: Submitted on: 10/12/2015; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; International Hip Society: Board or committee member; Journal of Arthroplasty: Editorial or governing board; Journal of Arthroplasty (Deputy Editor): Publishing royalties, financial or material support; Knee Society: Board or committee member; Orthopaedic Research and Education Foundation: Board or committee member; Wolters Kluwer Health - Lippincott Williams & Wilkins: Publishing royalties, financial or material support Herbert John Cooper, MD: Submitted on: 11/24/2015; AAOS: Board or committee member; Journal of Arthroplasty: Editorial or governing board; KCI: Paid consultant; Paid presenter or speaker; Research support Medacta USA: Paid consultant; Zimmer: Paid consultant Craig J Della Valle, MD: Submitted on: 10/01/2015; American Association of Hip and Knee Surgeons: Board or committee member; Arthritis Foundation: Board or committee member; Biomet: IP royalties; Paid consultant; Research support; CD Diagnostics: Research support; Stock or stock Options; DePuy, A Johnson & Johnson Company: Paid consultant; Hip Society: Board or committee member; Knee Society: Board or committee member; Mid America Orthopaedic Association: Board or committee member; Orthopedics Today: Editorial or governing board; SLACK Incorporated: Editorial or governing board; Publishing royalties, financial or material support; Smith & Nephew: Paid consultant; Research support; Stryker: Research support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Publishing royalties, financial or material support Douglas A Dennis, MD: Submitted on: 10/31/2015; Clinical Orthopaedics and Related Research: Editorial or governing board; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Paid presenter or speaker; DePuy, A Johnson & Johnson Company, Porter Adventist Hospital: Research support; Innomed: IP royalties; Joint Vue: Stock or stock Options; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery American: Editorial or governing board; Orthopedics Today: Editorial or governing board; Wolters Kluwer Health Lippincott Williams & Wilkins: Publishing royalties, financial or material support Lawrence Douglas Dorr, DMD: Submitted on: 01/31/2016; DJ Orthopaedics: IP royalties; Total Joint Orthopedics: Stock or stock Options Kyle Duchman, MD: (This individual reported nothing to disclose); Submitted on: 10/06/2015 Michael Dunbar, MD, PhD: Submitted on: 10/01/2015; Arthropaedia: Editorial or governing board; Canadian Joint Replacement Registry - Co-chair: Board or committee member; Canadian Orthopaedic Research Society-Program Chair: Board or committee member; Canadian RSA Network - Chair: Board or committee member; DePuy: Research support; EMOVI: Research support; Journal of Bone and Joint Surgery - British: Editorial or governing board; Kinduct: © 2016 The Knee Society 82 Research support; Knee: Editorial or governing board; Medical Advisory Board for the Arthritis Society of Canada: Board or committee member; Stryker: IP royalties; Paid consultant; Research support Zimmer: Research support Jacob Elkins, MD, PhD: (This individual reported nothing to disclose); Submitted on: 01/27/2016 Bill Farrington, FRACS, FRCS, FRCS (Ortho), MBBS: Submitted on: 01/27/2016; LIMA: Other financial or material support; Stryker: Paid presenter or speaker; Research support Thomas K Fehring, MD: Submitted on: 11/04/2015; American Association of Hip and Knee Surgeons: Board or committee member; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Paid presenter or speaker; Research support; Knee Society: Board or committee member Jonathan Mordechai Frank, MD: (This individual reported nothing to disclose); Submitted on: 01/26/2016 Mark I Froimson, MD: Submitted on: 01/29/2016; American Association of Hip and Knee Surgeons: Board or committee member; American Journal of Orthopedics: Editorial or governing board; American Orthopaedic Association: Board or committee member; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Medical Compression Systems: Paid consultant; Stock or stock Options; Mid American Orthopaedic Association: Board or committee member Yubo Gao, PhD: (This individual reported nothing to disclose); Submitted on: 01/31/2016 Kevin L Garvin, MD: Submitted on: 10/20/2015; AAOS: Board or committee member; American Orthopaedic Association: Board or committee member; Hip Society: Board or committee member; Wolters Kluwer Health Lippincott Williams & Wilkins: Editorial or governing board George Go: (This individual reported nothing to disclose); Submitted on: 01/26/2016 Fares Sami Haddad, FRCS: Submitted on: 10/02/2015; Annals of the Royal College of Surgeons England: Editorial or governing board; Bone and Joint Journal: Editorial or governing board; corin: IP royalties; Journal of Arthroplasty: Editorial or governing board; matortho: IP royalties; Orthopedics Today: Editorial or governing board; Smith & Nephew: IP royalties; Paid consultant; Research support; Stryker: Paid consultant Erik Nathan Hansen, MD: (This individual reported nothing to disclose); Submitted on: 02/02/2016 Curtis W Hartman, MD: Submitted on: 10/01/2015; Pfizer: Research support; Smith & Nephew: Paid consultant; Paid presenter or speaker; Research support; Trak Surgical, Inc: Unpaid consultant Stephen M Howell, MD: Submitted on: 10/01/2015; AAOS: Board or committee member; American Journal of Sports Medicine: Editorial or governing board; Biomet Sports Medicine: Paid consultant; Paid presenter or speaker; Saunders/Mosby-Elsevier: Publishing royalties, financial or material support; ThinkSurgical: Paid consultant; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Research support Colin Howie, ChB, MB, FRCS, FRCS (Ortho): Submitted on: 11/16/2015; British Orthopaedic Association: Board or committee member; Journal Trauma Orthopaedics and BJJ: Editorial or governing board Richard Iorio, MD: Submitted on: 01/19/2016; American Association of Hip and Knee Surgeons: Board or committee member; APOS Medical & Sports Technologies Ltd.: Research support; Bioventis: Research support; Clinical Orthopaedics and Related Research: Editorial or governing board; DJ Orthopaedics: Paid consultant; Ferring Pharmaceuticals: Research support; Hip Society: Board or committee member; JBJS Reviews: Editorial or governing board; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Journal of the American Academy of Orthopaedic Surgeons: Editorial or governing board; Knee Society: Board or committee member; MCS ActiveCare: Paid consultant; Orthofix, Inc.: Research support; Orthosensor: Research support; Pacira: Paid consultant; Research support; Vericel: Research support; Wellbe: Stock or stock Options Erdan Kayupov, MS: (This individual reported nothing to disclose); Submitted on: 01/26/2016 Aakash Keswani, BA: (This individual reported nothing to disclose); Submitted on: 01/27/2016 Jay R Lieberman, MD: Submitted on: 10/09/2015; AAOS: Board or committee member; American Association of Hip and Knee Surgeons: Editorial or governing board; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Hip Innovation Technology: Stock or stock Options; Journal of Arthroplasty: Editorial or governing board; Saunders/Mosby-Elsevier: Publishing royalties, financial or material support; Western Orthopaedic Association: Board or committee member © 2016 The Knee Society 83 Steve S Liu, MD: (This individual reported nothing to disclose); Submitted on: 01/28/2016 Adolph V Lombardi Jr, MD: Submitted on: 10/12/2015; Clinical Orthopaedics and Related Research: Editorial or governing board; Hip Society: Board or committee member; Innomed: IP royalties; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Journal of Orthopaedics and Traumatology: Editorial or governing board; Journal of the American Academy of Orthopaedic Surgeons: Editorial or governing board; Kinamed: Research support; Knee: Editorial or governing board; Knee Society: Board or committee member; Mount Carmel Education Center at New Albany: Board or committee member; Operation Walk USA: Board or committee member; Orthosensor: IP royalties; Paid consultant; Research support; Pacira Pharmaceuticals, Inc.: Paid consultant; Research support; Surgical Technology International: Editorial or governing board; Zimmer Biomet: IP royalties; Paid consultant; Research support Jess H Lonner, MD: Submitted on: 10/31/2015; American Journal of Orthopedics: Editorial or governing board; Blue Belt Technologies: IP royalties; Paid consultant; Paid presenter or speaker; Stock or stock Options; CD Diagnostics: Paid consultant; Stock or stock Options; Healthpoint Capital: Stock or stock Options; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Saunders/Mosby-Elsevier: Editorial or governing board; Publishing royalties, financial or material support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Editorial or governing board; Publishing royalties, financial or; material support; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Research support Steven J MacDonald, MD: Submitted on: 10/29/2015; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Research support; Hip Innovations Technology, JointVue: Stock or stock Options; Knee Society: Board or committee member; Smith & Nephew: Research support; Stryker: Research support Bassam A Masri, MD, FRCSC: Submitted on: 10/12/2015; Canadian Orthopaedic Association: Board or committee member; DePuy, A Johnson & Johnson Company: Research support; Journal of Arthroplasty: Editorial or governing board R Michael Meneghini, MD: Submitted on: 09/29/2015; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Stryker: IP royalties; Paid consultant; Research support Michael A Mont, MD: Submitted on: 10/22/2015; AAOS: Board or committee member; American Journal of Orthopedics: Editorial or governing board; DJ Orthopaedics: Paid consultant; Research support; Johnson & Johnson: Paid consultant; Research support; Journal of Arthroplasty: Editorial or governing board; Journal of Knee Surgery: Editorial or governing board; Medical Compression Systems: Paid consultant; Merz: Paid consultant; Microport: IP royalties; National Institutes of Health (NIAMS & NICHD): Research support; Ongoing Care Solutions: Research support; Orthopedics: Editorial or governing board; Orthosensor: Paid consultant; Research support; Pacira: Paid consultant; Sage Products, Inc.: Paid consultant; Stryker: IP royalties; Paid consultant; Research support; Surgical Techniques International: Editorial or governing board; Tissue Gene: Research support; TissueGene: Paid consultant; U S Medical Innovations: Paid consultant Mario Moric, MS: Submitted on: 11/23/2015; Zimmer: Paid consultant Calin Stefan Moucha, MD: Submitted on: 01/27/2016; 3M: Paid presenter or speaker; Saunders/Mosby-Elsevier: Publishing royalties, financial or material support Lauren Elizabeth Mount, MD: (This individual reported nothing to disclose); Submitted on: 11/25/2015 Daniel Beasley Murrey, MD: Submitted on: 01/26/2016; AAOS: Board or committee member; Amedica: Stock or stock Options; BioMedFlex: Stock or stock Options; Unpaid consultant; OrthoMedFlex: Stock or stock Options; Unpaid consultant; Stryker: IP royalties Allina A Nocon, MPH: (This individual reported nothing to disclose); Submitted on: 01/26/2016 Ryan Nunley, MD: Submitted on: 05/27/2015; American Association of Hip and Knee Surgeons: Board or committee member; Biocomposites: Paid consultant; Biomet: Research support; Blue Belt Technology: Paid consultant; Cardinal Health: Paid consultant; DePuy, A Johnson & Johnson Company: Paid consultant; Research support; Integra Sciences: Paid consultant; Medical Compression Systems, Inc.: Research support; Medtronic: Paid consultant; Microport: IP royalties; Paid consultant; Missouri State Orthopaedic Association Board Member: Board or committee member; Polaris: Paid consultant; Smith & Nephew: Paid consultant; Research support; Southern Orthopaedic Association Board Member: Board or committee member; Stryker: Research support Kamil Okroj, BA: (This individual reported nothing to disclose); Submitted on: 01/26/2016 © 2016 The Knee Society 84 Mary I O'Connor, MD: Submitted on: 10/03/2015; Accelalox, Inc.: Stock or stock Options; Accelatox, Inc.: Unpaid consultant; Zimmer: Paid consultant Mark W Pagnano, MD: Submitted on: 01/31/2016; DePuy, A Johnson & Johnson Company: IP royalties; Hip Society: Board or committee member; Knee Society: Board or committee member; Pacira: Paid consultant; Stryker: IP royalties Javad Parvizi, MD, FRCS: Submitted on: 09/09/2015; 3M: Research support; CD Diagnostics: Stock or stock Options; Cempra: Research support; CeramTec: Research support; Datatrace: Publishing royalties, financial or material support; DePuy, A Johnson & Johnson Company: Research support; Eastern Orthopaedic Association: Board or committee member; Elsevier: Publishing royalties, financial or material support; Hip Innovation Technology: Stock or stock Options; Jaypee Publishing: Publishing royalties, financial or material support; Journal of Arthroplasty: Editorial or governing board; Journal of Bone and Joint Surgery - American: Editorial or governing board; Journal of Bone and Joint Surgery - British: Editorial or governing board; Muller Foundation: Board or committee member; National Institutes of Health (NIAMS & NICHD): Research support; OREF: Research support; PRN: Stock or stock Options; SLACK Incorporated: Publishing royalties, financial or material support; Smith & Nephew: Paid consultant; Research support; StelKast: Research support; Stryker: Research support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Publishing royalties, financial or material support; Zimmer: Paid consultant; Research support Paul Pavlou, FRCS (Ortho): (This individual reported nothing to disclose); Submitted on: 01/26/2016 Gregory G Polkowski, II MD: Submitted on: 06/11/2015; American Association of Hip and Knee Surgeons: Board or committee member Andrew James Pugely, MD: (This individual reported nothing to disclose); Submitted on: 10/17/2015 Michael D Ries, MD: Submitted on: 11/11/2015; Foundation for the Advancement of Research in Medicine: Board or committee member; OrthAlign: Stock or stock Options; Smith & Nephew: IP royalties; Paid consultant; Stryker: Paid consultant Aaron Glen Rosenberg, MD, FACS: Submitted on: 10/05/2015; Wolters Kluwer Health - Lippincott: Publishing royalties, financial or material support; Wolters Kluwer Health - Lippincott Williams & Wilkins: Editorial or governing board; Zimmer: IP royalties; Paid consultant; Paid presenter or speaker; Stock or stock Options W Norman Scott, MD: Submitted on: 01/08/2016; Author, Surgery of the Knee 5th Edition, Elsevier: Publishing royalties, financial or material support; Author, Surgery of the Knee 6th Edition, Elsevier: Publishing royalties, financial or material support; OrthoDevelopment Medical Advisor to Board of Directors: Paid consultant; President & CEO ICJR (International Congress for Joint Reconstruction): Board or committee member; Zimmer Past Royalty Bearing Designer: IP royalties Thomas P Schmalzried, MD: Submitted on: 05/27/2015; DePuy, A Johnson & Johnson Company: IP royalties; Stock or stock Options; None: Research support; Orthopaedic Research and Education Foundation: Board or committee member; Orthopedics Today: Editorial or governing board; Stryker: IP royalties; Paid consultant; Paid presenter or speaker; Stock or stock Options Thomas P Sculco, MD: Submitted on: 10/08/2015; American Journal of Orthopedics: Editorial or governing board Exactech, Inc: IP royalties; Knee Society: Board or committee member John Segreti: Submitted on: 02/03/2016; Merck: Paid presenter or speaker; Pfizer: Stock or stock Options Nigel E Sharrock, MD: Submitted on: 01/26/2016; OR Comfort: Stock or stock Options; USCom: Stock or stock Options Bryan Donald Springer, MD: Submitted on: 10/01/2015; AJRR: Board or committee member; Arthroplasty Today: Editorial or governing board; Convatec, Polaris: Paid consultant; DePuy, A Johnson & Johnson Company, Ceramtec: Paid presenter or speaker; Joint purifications systems.: Other financial or material support; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member; Stryker: Paid consultant S David Stulberg, MD: Submitted on: 10/31/2015; Aesculap/B.Braun: IP royalties; Paid consultant; Paid presenter or speaker; Biomet: IP royalties; blue belt technologies: Stock or stock Options; Innomed: IP royalties; Johnson & Johnson: Stock or stock Options; Peachtree Publishers: Publishing royalties, financial or material support; Stryker: IP royalties; Paid consultant; Paid presenter or speaker; Stock or stock Options; Zimmer: Paid consultant; Paid presenter or speaker; Stock or stock Options Edwin P Su, MD: Submitted on: 01/27/2016; American Journal of Orthopedics: Editorial or governing board; Orthoalign, Inc: Stock or stock Options; Smith & Nephew: Paid consultant; Research support © 2016 The Knee Society 85 Robert T Trousdale, MD: Submitted on: 01/26/2016; American Association of Hip and Knee Surgeons: Board or committee member; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Hip Society: Board or committee member; Journal of Arthroplasty: Editorial or governing board; Knee Society: Board or committee member Thomas Parker Vail, MD: Submitted on: 10/04/2015; American Board of Orthopaedic Surgery, Inc.: Board or committee member; DePuy, A Johnson & Johnson Company: IP royalties; Paid consultant; Knee Society: Board or committee member Matthew L Walker, MD: Submitted on: 01/26/2016; Stryker: Research support Robert W Westermann, MD: (This individual reported nothing to disclose); Submitted on: 01/27/2016; Report: Adam Young, MD: (This individual reported nothing to disclose); Submitted on: 01/26/2016 Simon Young, MD, FRACS: Submitted on: 01/26/2016; Stryker: Research support; Vidacare: Research support STAFF Olga Foley: (This individual reported nothing to disclose); Submitted on: 10/05/2015 Lisa DuShane: (This individual reported nothing to disclose); Submitted on: 11/05/2015 The Knee Society 9400 W. Higgins Road, Suite 500 Rosemont, IL 60018-4976 Phone: (847)698-1632 Fax: (847)823-0536 Email: [email protected] Website: www.kneesociety.org American Association of Hip and Knee Surgeons 9400 W. Higgins Rd., Suite 230 Rosemont, IL 60018-4976 Phone: (847)698-1200 Fax: (847)698-0704 Email: [email protected] Website: www.aahks.org Please complete the evaluation online at: https://www.surveymonkey.com/r/KSSD16 or use the QR Code to access. © 2016 The Knee Society 86