Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Doctor’s Digest november 2010 A monthly newsletter for St. Louis Children’s Hospital attending and referring medical staffs In this issue 3 Kids with Sports Concussions Need Time Out 4 Mental Maturity Scan Tracks Brain Development 6 Surgical Case Study: Complex Cholodochal Cyst in 15-Year-Old Clinical Focus |Adolescent Bariatric Clinic Helps Obese Teens at High-Risk for Medical Problems St. Louis Children’s Hospital (SLCH) has teamed with the Washington University Surgical Weight Loss Program and Barnes-Jewish Hospital to establish the first adolescent bariatric clinic in the St. Louis area. The clinic focuses on teens whose weight is causing them to have significant medical problems that likely will result in serious complications as they mature into adulthood. “We are seeing an increased incidence of really severe complications from obesity in adolescents, including high blood pressure, type 2 diabetes, metabolic syndrome and Blount’s disease,” says Abby Hollander, MD, interim division director of endocrinology and diabetes at SLCH. “While diet and exercise remain the gold standard for weight loss, teens who are severely obese often have extreme difficulty reducing their BMIs into a normal range. Although it’s not known why this is true—both hereditary and environmental factors probably play a role—the fact remains that many of these teens benefit greatly from undergoing bariatric surgery.” SLC6990 10/2010 Criteria for teens seen at the adolescent bariatric clinic include: •15 to 19 years of age with a BMI of 40 or greater •diagnosis of a serious medical condition •maturity level needed to undergo major surgery and commit to a new lifestyle All patients undergo an evaluation by an SLCH pediatric endocrinologist; Esteban Varela, MD, FACS, Washington University bariatric surgeon and clinic co-director; a psychologist and a registered dietitian. Families also are evaluated to gauge their commitment to providing emotional support and helping to change the teen’s living environment. In addition, before undergoing surgery all patients must first complete a six-month weight management program during which they either lose or maintain their weight. This requirement shows patients’ commitment to adhering to healthy eating, and it helps them learn the lifestyle and diet changes they’ll need to make following surgery. Those changes include eating only three small meals a day, eating only healthy foods, not snacking, giving up soda and exercising at least 30 minutes a day. Dr. Varela notes that bariatric surgery is becoming more common in obese teens, and new research suggests it may be more effective than behavioral programs alone. Dr. Varela was the lead author in a study that showed bariatric surgery in adolescents has proven to be as safe as in the adult population.1 continued on next page continued from previous page Share Your Ideas Should you have ideas or suggestions you would like brought before the Children’s Medical Executive Committee (CMEC), contact one of your CMEC private physician representatives: Jean E. Birmingham, MD 314.918.8827 Peter Putnam, MD 314.965.5437 Isabel L. Rosenbloom, MD 314.291.7766 Kathie Wuellner, MD 618.474.1711 Let Us Hear From You If you have comments or suggestions regarding Doctor’s Digest, or if you would like to share information about your activities as a physician, contact: Amy Connelly Marketing and Communications St. Louis Children’s Hospital 600 South Taylor Ave. Suite 202 St. Louis, MO 63110 Mailstop 90.94.210 314.286.0324 fax: 314.286.0420 [email protected] Doctor’s Digest Published for the attending and referring medical staffs of St. Louis Children’s Hospital. Lee F. Fetter President Alison Nash, MD Medical Staff President Perry Schoenecker, MD Medical Staff President-Elect 2| “Performing bariatric surgery when patients are adolescents means we can have a significant impact on their lives early on,” says Dr. Varela. “Their overall health and quality of life is drastically improved, and that means avoiding the irreversible health issues that adults deal with even after they’ve undergone bariatric surgery.” Dr. Varela performs three types of bariatric surgeries: adjustable gastric band, Roux-enY gastric bypass and vertical sleeve gastrectomy. Three types of bariatric surgeries • Adjustable gastric band, which decreases food intake by placing a small braceletlike band around the top of the stomach to produce a small pouch about the size of a thumb. The outlet size is controlled by a circular balloon inside the band that may be inflated or deflated with saline solution to meet the needs of the patient. • Roux-enY gastric bypass, which restricts food intake and decreases food absorption. Food intake is limited by a small pouch similar in size to the adjustable gastric band. In addition, food absorption in the digestive tract is reduced by excluding most of the stomach, duodenum and upper intestine from contact with food by routing food directly from the pouch into the small intestine. • Vertical sleeve gastrectomy, which restricts food intake but does not lead to decreased food absorption. Approximately 60 percent of the stomach is removed, reshaping it into a tube or “sleeve.” “All of these surgeries are done laparoscopically, which means patients’ hospital stays are only a day or two,” he says. “They are followed closely for the first year and then have annual check-ups.” He adds, “Of course, surgery is always the last resort for adolescents who are obese. But when they are at high risk for developing severe health problems as adults and they have been unable to reduce their weight any other way, this intervention is the best course for them.” For more information about the adolescent bariatric clinic, call Children’s Direct at 800.678.HELP (4357). 1 Varela JE, Hinojosa MW, Nguyen NT. Perioperative outcomes of bariatric surgery in adolescents compared with adults at academic medical centers. Surgery for Obesity and Related Diseases, September 2007;3(5):537-40. Children’s Direct Line 800.678.4357 StLouisChildrens.org Medical Update | Kids with Sports Concussions Need Time Out – By Jim Dryden Between 1997-2007, the number of emergency room visits for concussions doubled in children ages 8 to 13 who play organized sports. Mark E. Halstead, MD Part of the reason is greater awareness, according to Mark E. Halstead, MD, pediatric orthopedic surgeon at St. Louis Children’s Hospital and assistant professor of orthopedic surgery and of pediatrics at Washington University School of Medicine. “I think, overall, there probably aren’t many more concussions,” Dr. Halstead says. “What we’re really seeing is more attention. People are seeking more medical attention because that’s what we’re recommending.” Dr. Halstead, who is director of Washington University in St. Louis’ Sports Concussion Program, is first author on a report with new guidelines for managing sports-related concussions. The recommendations give advice to both parents and physicians and appear in the September issue of Pediatrics. Young athletes are especially vulnerable because their brains are still developing and may be more susceptible to the effects of a concussion, according to Dr. Halstead. As recently as 10 years ago, a child with a low-grade concussion may have been allowed to return to action as soon as 15 minutes after symptoms had subsided, he says. Now, Dr. Halstead’s team recommends that no athlete be allowed back into competition the same day. In some cases, he says, it may be weeks or even months before it’s safe to go back on the playing field. At the very least, he recommends — and now laws in many states require — that young athletes be evaluated and cleared by a physician before returning to competition. dramatic swelling in the brain and even die following that second injury. That syndrome is unique to the pediatric population. We’ve never seen it happen in a professional athlete.” To avoid those devastating consequences, Dr. Halstead says it’s never appropriate to allow young athletes to return to action the same day an injury is sustained. In fact, he says athletes should not return to physical activity of any kind until they are symptom-free. And in some cases, in addition to resting from physical activity, young athletes may need what he calls “brain rest,” including temporarily refraining from school work, video games, television and reading. “All of those activities can aggravate symptoms, so we want them to refrain from those things in order to heal better,” he says. “Once they are okay when at rest, we can allow them to slowly begin physical activity, while paying close attention to ensure that symptoms don’t return.” These are the first concussion guidelines published for athletes younger than high-school age. Previous guidelines used in older athletes defined concussions in stages, as either grade 1, 2 or 3. The length of rehabilitation was determined by the grade of the concussion. These new recommendations, Dr. Halstead says, urge doctors to avoid that kind of “cookie cutter” approach and to allow individuals back into competition only after they feel better and symptoms have subsided. Verifying that, however, requires cooperation from the patient. “That’s the trouble with a concussion as opposed to a knee injury,” Dr. Halstead says. “When a kid hurts a knee, he or she goes limping off the field and can’t put weight on the leg. With a head injury, a lot of times we’re relying on the athlete to tell us that he or she is having problems. We want kids and coaches to know the signs and symptoms. That way, if there’s any question, they can be evaluated. Especially in children, concussions aren’t something to ‘monkey around’ with.” For more information about the Sports Concussion Program or to speak with Dr. Halstead, contact Children’s Direct at 800.678.HELP (4357). Common signs and symptoms of a concussion include headache (by far the most common symptom), dizziness or memory or concentration problems, in which many athletes will describe feeling “foggy.” Some also may feel sick to their stomachs or have issues with balance. “If someone has taken a blow to the head and they’re feeling some of those symptoms, parents and coaches need to assume that the player has suffered a concussion,” Dr. Halstead says. “We always tell people to err on the side of caution.” That’s particularly important in younger children. Although concussions are more common among older athletes due to more violent collisions involving bigger bodies at higher speeds, concussions have the potential to be much more dangerous in younger athletes whose brains are still growing and developing. “There is a problem called ‘second impact syndrome’ that affects children but is not seen in older athletes,” Dr. Halstead says. “If a child returns to competition too soon and suffers another head injury, they can develop |3 Research Update | Mental Maturity Scan Tracks Brain Development Five minutes in a scanner can reveal how far a child’s brain has come along the path from childhood to maturity and potentially shed light on a range of psychological and developmental disorders, scientists at Washington University School of Medicine have shown. Researchers assert in the September 10 issue of Science that their study proves brain imaging data can offer more extensive help in tracking aberrant brain development. “Pediatricians regularly plot where their patients are in terms of height, weight and Bradley Schlagger, MD other measures, and then match these up to standardized curves that track typical developmental pathways,” says senior author Bradley Schlaggar, MD, PhD, a pediatric neurologist at St. Louis Children’s Hospital. “When the patient deviates too strongly from the standardized ranges or veers suddenly from one developmental path to another, the physician knows there’s a need to start asking why.” Dr. Schlaggar and his colleagues say a new way of looking at brain scanning data may be able to provide similar guidance for monitoring and treating of patients with psychiatric and developmental disorders. Dr. Schlaggar, the A. Ernest and Jane G. Stein Associate Professor of Neurology and associate professor of radiology, anatomy and neurobiology, and pediatrics at Washington University School of Medicine, says he has sent children with obvious, profound psychiatric conditions for MRI scans and received results marked “no abnormalities noted.” “That’s typically looking at the data from a structural point of view—what’s different about the shapes of various brain regions,” he says. “But MRI also offers ways to analyze how different parts of the brain work together functionally.” Compare functional data to standardized models of how brain function or disease normally develops, Dr. Schlaggar says, and a range of new clinical insights becomes available. Dr. Schlaggar and his colleagues use an approach to brain scanning called resting state functional connectivity. By correlating increases and decreases in blood flow to the various brain regions as subjects rest in the scanner, scientists determine which of these regions work together in brain networks. 4| In a study published in 2009, Washington University scientists showed that as the brain matures, these brain networks change (visit StLouisChildrens.org/dd for a link to the article). The overall organization switches from networks involving regions physically close to each other — which is the dominant motif in a child’s brain — to networks that connect distant regions — the primary organizational principal in adult brains. For the new study, lead author Nico Dosenbach, MD, PhD, a pediatric neurology resident at St. Louis Children’s Hospital, took this and other distinctions that mark the transition from child to adult brain and adapted them for use in a technique for mathematical analysis called a support vector machine. The technique is employed in many contexts in science and economics and on the Internet. “It’s a way that mathematicians have developed for predicting something with high specificity and sensitivity when you have huge amounts of data instead of one really good measurement,” Dr. Dosenbach explains. “Any one of these measurements alone doesn’t tell you much, but if you put them together and use the right math to sift through and restructure them, you can get good predictive results.” Researchers charted the results of 238 brain maturity analyses, with age on the horizontal axis and maturity on the vertical axis. Dr. Dosenbach used data from five-minute MRI scans of 238 normal subjects ranging in age from 7 to 30. The support vector machine analyzed approximately 13,000 functional brain connections and selected the best 200 to produce a single index of the maturity of each subject. The data allowed scientists to predict whether subjects were children or adults, and roughly formed a curving line that tracks the path of normal functional brain development. The researchers suspect patients with brain disorders will appear out of alignment with this normal developmental curve. “The beauty of this approach is that it lets you ask what’s different in the way that children with autism, for example, are off the normal development curve versus the way children with attention-deficit disorder are off that curve,” Dr. Schlaggar says. Dr. Schlaggar suggests that functional brain scans might be conducted on a group of children at risk but not yet suffering from a developmental disorder. Children’s Direct Line 800.678.4357 StLouisChildrens.org “When a fraction of them later develop that disorder, you can go back and construct an analysis like this one that will help predict the characteristics of the next child at highest risk of developing the disorder,” he says. “That’s very powerful both clinically and from the perspective of understanding the causes of these disorders.” This approach might enable treatment prior to onset of symptoms, Dr. Schlaggar says, and should help physicians more quickly and closely track the results of clinical trials of new therapies. “MRI scans are expensive, so this may not be what we use for everyone right now,” Dr. Dosenbach says. “But many children with these types of disorders already receive regular structural MRI scans, and five more minutes in the scanner won’t add that much to the cost.” Dosenbach NUF, Nardos B, Cohen AL, Fair DA, Power JD, Church JA, Nelson SM, Wig GS, Vogel AC, Lessov-Schlaggar CN, Barnes KA, Dubis JW, Feczko E, Coalson RS, Pruett JR JR, Barch DM, Petersen SE, Schlaggar BL. Prediction of individual brain maturity using fMRI. Science, Sept. 10, 2010. Funding from the National Institutes of Health, the John Merck Scholars Fund, the BurroughsWellcome Fund, the Dana Foundation, the Ogle Family Fund, the McDonnell Center, the Simons Foundation, the American Hearing Research Foundation, and the Diabetes Research Center at Washington University supported this research. Research Multi-Year Study Investigates Effect of Environment and Genetics Update on Children’s Health The National Children’s Study (NCS) is the largest study of child health ever conducted in the United States, and it began last month in the St. Louis area. The overall goal of the NCS is to study how the environment and gene-environment interactions influence children’s health, development and quality of life. A total of 79 metropolitan areas and 26 rural communities were chosen randomly to recruit 100,000 children to represent the diversity found across the country. Locally, the following schools are partnering to assess children in St. Louis City and Jefferson County in Missouri, and Macoupin County and Johnson/Williamson/Union Counties in Illinois: • Washington University School of Medicine • Saint Louis University Schools of Public Health and Medicine • Southern Illinois University Edwardsville School of Nursing • Southern Illinois University School of Medicine • Southern Illinois University Carbondale • Battelle St. Louis Operations Together, these institutions and communities form the Gateway Study Center. In September 2010, the Gateway Study Center began recruiting pregnant women (or women who are planning on becoming pregnant in the near future) from randomly chosen segments of St. Louis City. The children will be followed from before birth until age 21 years. Interval assessments of the environment and of the children will be completed to determine the impact of the environment on child health and development. Environment is defined broadly to include physical, chemical, biological, and psychosocial factors. Findings from the NCS will be made available as the research progresses, making potential benefits known to the public as soon as possible. The Gateway Study Center has been working with a Community Advisory Board and determining the needs of local communities in preparation for this study. The majority of participants will join through door-to-door, census-type recruitment efforts. Others will join through physicians’ offices and health clinics. A local media campaign will emerge in the fall as well. “The NCS will succeed only with the collaboration of researchers, community organizations, healthcare providers, social service agencies, and other local groups,” says Allison King, MD, MPH, co-principal investigator and hematology and oncology physician at St. Louis Children’s Hospital. “The data gathered from this study will serve as the foundation for child health guidelines and interventions for years to come.” Oversight of the NCS is provided by a consortium of federal partners that includes the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Environmental Health Sciences, the Centers for Disease Control and Prevention, and the U.S. Environmental Protection Agency. Funding for the NCS is appropriated annually by Congress, separate from the NIH budget, and then administered by NICHD. To learn more about the study, visit nationalchildrensstudy.gov. |5 Surgical Case Study | Complex Cholodochal Cyst in 15-Year-Old Physicians: Brad Warner, MD, surgeon-in-chief, St. Louis Children’s Hospital (SLCH) William Hawkins, MD, hepatobiliary pancreatic and gastroenterology surgeon, Barnes-Jewish Hospital (BJH) Shawn Larson, MD, pediatric surgery fellow, SLCH Background The patient, 15-year-old Amanda, had been experiencing severe abdominal pain, to the point of twice visiting a hospital emergency room in her hometown of Springfield, Illinois. According to her mother, Lisa, Amanda had frequent stomach problems throughout her life; even as an infant, Lisa described her daughter as being a “puker.” “Amanda’s stomach pain began getting out of control. We didn’t know that she’d already been diagnosed as having a cholodochal cyst,” says Lisa. “It was identified on CT scans done when Amanda had her appendix removed at age 14. Unfortunately, we weren’t told about that discovery.” Amanda was seen by a local surgeon, who performed an endoscopic retrograde cholangiopancreatography (ERCP). The study showed Amanda had a large cyst located within the head of her pancreas. In an attempt to alleviate Amanda’s pain, the surgeon placed a stent within the pancreas as a drain. When another study showed the cyst hadn’t changed, Lisa contacted Dr. Warner at St. Louis Children’s Hospital. The surgical challenge: “Usually cholodochal cysts are diagnosed in infants and young children when they present with jaundice,” says Dr. Warner. “However, most of these cysts involve the bile duct above the pancreas. In Amanda’s case, her cyst was actually within the pancreas, which is probably the reason her symptom was stomach pain rather than jaundice. No matter the position of these cysts, however, we remove them because these patients are at risk for developing pancreatitis and, over time, cancer in the bile duct.” The location of Amanda’s cyst meant she needed a more complex surgery than usual to remove it. Dr. Warner first considered a Whipple procedure, which most often is the treatment for pancreatic cancer. It involves removing the head of the pancreas, the duodenum and part of the bile duct. “The Whipple is associated with a significant complication rate and long-term consequences in young teenagers,” says Dr. Warner. “Early on there’s a risk of leakage from the point where the intestine and what remains of the pancreas are sewn together. Long term, there’s the risk of malnutrition because patients are unable to gain weight and grow well. In addition, the blood supply to the stomach and pylorus is sometimes disturbed, resulting in problems with the stomach emptying.” He adds, “It was obvious a Whipple procedure was not the ideal surgery for Amanda, which led me to consult with my surgical colleagues at Barnes-Jewish Hospital. I found they had experience with these more-complex cholodochal cysts in the adult population. 6| Fortunately, our mutual affiliation with Washington University School of Medicine makes this type of collaboration possible.” The surgical approach: Drs. Warner and Hawkins’ alternative surgical approach was to identify the bile duct above the pancreas, cut across it, and then, with traction on the lower bile duct, dissect close to the bile duct wall and ultimately identify the cyst. They removed the cyst within the pancreas gland without cutting across any pancreas tissue but rather with traction on the cyst and gentle dissection. “We left open the upper part of the bile duct coming from the liver and removed the lower part all the way down to where it joined the pancreas duct. We oversewed it there,” explains Dr. Warner. “To replace the missing segment of bile duct within the pancreas, we brought up a loop of intestine and sewed it to the bile duct coming out of the liver. Now instead of the bile going through the bile duct and pancreas, into the cyst and then into the duodenum, the bile goes out of the liver into the upper bile duct and then drains directly into a piece of small intestine.” The outcome: Approximately six months after the surgery, Amanda is doing well, with testing showing normal pancreas and liver enzymes. Other than periodic check-ups, she does not require medications or any other ongoing treatment. “Amanda was a great patient—really upbeat, and she worked hard at getting better after the surgery,” says Dr. Warner. “The outcome was significantly better than may have been possible following a Whipple procedure. It was gratifying to offer her and her family a more effective, less invasive surgical solution thanks to the combined expertise of pediatric and adult surgeons.” Children’s Direct Line 800.678.4357 StLouisChildrens.org Faculty Scoliosis Research Society (SRS) Update Installs Lenke as President Lawrence G. Lenke, MD, a pediatric orthopedic spinal surgeon at St. Louis Children’s Hospital, has been installed as the 40th president of the Scoliosis Research Society (SRS) at its annual meeting in Kyoto, Japan. The SRS is an international organization, the oldest spinal society in the world, with a singular mission to foster the optimal care of all spinal deformity patients. “The SRS has always been associated with excellence, encompassing members from around the world who provide the highest level of care to their patients with various spinal problems,” says Dr. Lenke. “It’s an honor to work with the board of directors, committee chairs and members in helping to lead and shape the organization’s future.” Dr. Lenke, the Jerome J. Gilden Endowed Professor of Orthopaedic Surgery and Professor of Neurological Surgery at Washington University School of Medicine, specializes in spinal surgery with an emphasis on complex reconstructive surgery and treatment of various spinal deformities such as scoliosis and kyphosis. He is known for treating the most challenging cases of pediatric spinal deformity throughout this country and beyond. After receiving his medical degree at Northwestern University Medical School, Dr. Lenke completed his internship and residency as well as fellowship training in pediatric and adult spinal surgery at Washington University School of Medicine in the Department of Orthopaedic Surgery. Since 1992, he has maintained an active clinical and research practice here at the medical center. Together with his partner, Keith H. Bridwell, MD, the ASA A. Jones Professor of Orthopaedic Surgery, and 2003 SRS president, they have contributed more presentations on spinal deformity surgery topics at the annual SRS meeting than any other program in the world over the past 20 years. The SRS is a professional organization of physicians and allied health personnel. Their primary focus is on providing continuing medical education for health care professionals and on funding/supporting research in spinal deformities. Founded in 1966, the SRS has gained recognition as one of the world’s premier spine societies. Strict membership criteria ensure that the individual Fellows support that commitment. Current membership includes over 1,100 of the world’s leading spine surgeons and researchers involved in the treatment of spinal deformities. New Physicians at SLCH Jaime P. Hook, MD Instructor in Psychiatry (Child), WUSM Specialty: Child Psychiatry Education/Training: • Child & adolescent psychiatry fellowship, St. Louis Children’s Hospital • Psychiatry residency, Saint Louis University Hospital, St. Louis • Medical degree, Saint Louis University School of Medicine Departing Medical Staff Members Susan Foerster, MD, Pediatric Interventional Cardiology Children’s Holiday Festival December 3 - 5 The Children’s Holiday Festival, presented by Peabody Energy, is quickly becoming a local holiday tradition. Stroll through 6,000 square feet of winter wonderland at the St. Louis Science Center featuring more than 65 trees which have been lavishly decorated for the holidays by top local designers, artists, businesses and families. Designer trees and wreaths will be available for immediate purchase or auction and all proceeds will benefit St. Louis Children’s Hospital. Special honorary trees that have been specifically decorated for a patient at Children’s Hospital will also be on display. Following the event, these trees will be donated and delivered to the child’s home to brighten their holiday season. Admission to the festival is free and open to the public. The Children’s Holiday Festival Preview Party and Tree Auction, Dec. 1, offer a special preview of the trees and opportunity to bid on auction items. Tickets for the preview party are available for $75 per guest. For more information, call the St. Louis Children’s Hospital Foundation at 314.286.0987 or visit StLouisChildrens.org/dd for a link to the Web site. Chief Resident Award | Whitney Bour, MD Each month, St. Louis Children’s Hospital’s chief residents honor a resident who shows exceptional dedication to his or her patients, colleagues or profession. In September, the SLCH Chief Resident Award was presented to Whitney Bour, MD, first-year pediatrics resident, in recognition of her extraordinary empathy and work ethic. Her performance was outstanding while caring for medically complex infants in the neonatal intensive care. |7 One Children’s Place St. Louis, MO 63110 Marketing and Communications 314.286.0324 Fax: 314.286.0420 In this issue 1 5 7 Adolescent Bariatric Clinic Helps Obese Teens at High-Risk for Medical Problems Multi-Year Study Investigates Effect of Environment and Genetics on Children’s Health Scoliosis Research Society (SRS) Installs Lenke as President Upcoming Events | Plan Now for 2011 Plan now to attend St. Louis Children’s Hospital’s continuing education programs in 2011. Join us to learn more about important issues related to pediatric and newborn health care. April 15: Current Concepts in Pediatric Trauma Care Eric P. Newman Education Center, St. Louis, Missouri. April 16: 18th Annual Emergency Medicine Conference Eric P. Newman Education Center, St. Louis, Missouri. April 27: Telephone Triage Conference Sheraton Clayton Plaza Hotel, Clayton, Missouri. May 6: Spring Clinical Pediatric Update: Pediatric Mental Health Symposium The Westin St. Louis, St. Louis, Missouri. Topics include eating disorders, psychopharmacology 201, disruptive behavior, adolescent substance abuse, depression screening, motivational interviewing and preschool psychotherapy June 3 – 4: Midwest Pediatric Hospital Medicine Conference Renaissance Grand Hotel, St. Louis, Missouri. Visit StLouisChildrens.org/Med_Ed to learn more about these and other educational programs. Non-profit Organization U.S. Postage PAID St. Louis, MO Permit No. 617