Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Tuesday
Document related concepts
no text concepts found
Transcript
Tuesday May 3, 2016 199 200 200 326 General Business Meeting Tahoma 5, TCC 309 Bipolar, Horizontal and Amacrine cells [VN] #2829-2835 356 Integration in stem cell therapy a challenge and a hope for vision — SIG [NT, AP, CL, RE, RC, VN] 336 Corneal Wound Repair and Regenerative Medicine [CO] #3475-3481 308 THC, Telehealth and Trichiasis: A CL potpourri [CL] #2822-2828 Tahoma 3, TCC 337 Next generation sequencing: What’s next? — Minisymposium [BI] #3482-3488 355 Applications of Genome Editing Techniques in Biology of Anterior Segment — SIG [AP, BI, CL, CO, GL, LE, GEN] 335 Photoreceptor degeneration, rescue and live imaging [RC] #3468-3474 307 Stem Cells: Disease Models and Therapeutics I [RC] #2815-2821 Tahoma 1/2, TCC Tahoma 4, TCC 354 Big Data and Data Visualization - Novel insights into retina disorders, glaucoma and cataract — SIG [GL, RE] 334 Eye and pregnancy — Minisymposium [IM, CL, CO, LE, PH, RE] #3463-3467 Skagit 4/5, TCC 618-620 349 MOI Group - Intra-operative OCT [MOI] 333 Drug Delivery [PH] #3456-3462 306 Cornea Endothelium [CO] #28082814 615-617 Minisymposium [VI, CL, EY, RE] 3450-3455 332 Optics of the eye and vision — 305 AO Imaging [VI] #2801-2807 611/612 351 Identifying Your Career Options using MyIDP, ScienceCareers.org, LinkedIn & More 352 NIH-CSR Workshop on the Review of Grant Applications 331 Lens Development [LE] #3443-3449 609 608 330 Dry Eye: Clinical and Epidemiology [CO] #3436-3442 350 Making a difference — how you can advocate your research to patients and the public using social media as an effective outreach tool 304 Ocular Surface Neovascularization, Innervation, and Immunology [CO] #2794-2800 353 Managing Patients with Diabetic Macular Edema, Neovascular AMD, and Retinal Vein Occlusion: How to Best Utilize Data from Clinical Trials — SIG [RE, CL, IM, PH, VN] 358 MIT Outstanding Poster Award Competition 1–2:30pm Cross-Sectional Group/Workshops/SIGs 606/607 329 Retinal Vascular Diseases [RE] #3429-3435 328 OCT Angiography 2 [RE] #3422-3428 327 Glaucoma Visual Fields and Visual Function [GL] #3415-3421 11am–12:45pm Papers/Minisymposia 357 Eighth Annual Women in Eye and Vision Research (WEAVR) Luncheon 303 Imaging the ocular circulation Minisymposium [RE] #2785-2793 6C 10:15–10:55am 6E 302 Glaucoma Neuroprotection [GL] #2778-2784 301 Fluids inside and around the eyes in ocular health and pathologies — Minisymposium [AP, GL, NT, PH, RE] #2772-2777 8:30–10:15am Papers/Minisymposia 6B 6A 2AB Room Tuesday, May 3 373 Connecting the retina to the brain: The mouse — Minisymposium [VN] #3848-3852 372 Photoreceptor degeneration and phototransduction [BI] #3841-3847 371 A wide view on Glaucoma epidemiology [CL] #3834-3840 370 Retinal Development II: Cell differentiation and determination [RC] #3827-3833 369 Microbiology / Immunology / Translational / Innate immunity [IM] #3820-3826 368 Amblyopia [EY] #3813-3819 367 Trabecular Meshwork and Aqueous Humor Dynamics [GL] #3806-3812 366 Optical imaging, adaptive optics and vision [VI] #3799-3805 365 Lens fiber cell biology [LE] #3792-3798 364 Novel signaling mechanisms in refractive development [AP] #3785-3791 363 Corneal cell and molecular biology and imaging [CO] #3778-3784 362 AMD Imaging [RE] #3771-3777 361 Retinal Stem Cells and Transplantation [RE] #3766-3770 360 Glaucoma Imaging I [GL] #3759-3765 3:45 –5:30pm Papers/Minisymposia 1 – 2:30pm Room 2AB MIT Outstanding Poster Award Competition 5:45 – 7pm 6B ARVO/ Champalimaud Award Lecture 1:00 – 2:30pm Room 6E (tickets required) 8th Annual WEAVR Luncheon on Skybridgel 9am – 4pm NAEVR Central 9am – 5:30pm Exhibit Hall opens 7am Exhibit hours Atrium Lobby 7am – 6pm ARVO Annual Meeting Registration 386 ARVO/Champalimaud Award Lecture 5:45–7pm 201 Glaucoma Clinical studies / Pharmacology [GL, RE] Trauma: Effects and Outcomes [CL] Lens development and fiber cell biology [LE] Amblyopia [EY] IOL Optical Properties and Presbyopia Correction [VI] Retinal Genetics [GEN] Molecular and biochemical mechanisms of retinal disease [BI] Diabetic Retinopathy [RC] Diabetic retinopathy and steroids [RE ] Inflammation / Infection/ Imaging / Non infectious Uveitis [IM, GL] AMD and anti-VEGF Therapy 2 [RE ] Clinical Imaging - Miscellaneous [MOI, LE, LV] 314 315 316 317 318 319 320 321 322 323 324 325 Corneal Neovascularization and Conjunctival Cell Biology and Surgery [CO, RC] Glaucoma Biomechanics [GL] Ganglion Cells and Beyond [VN, LV] Clinical electrophysiology [VN] Genes and proteins in myopia: Humans and Animal models [AP] Retinoids and carotenoids: Visual cycle and macular pigment [BI] Angiogenesis: Molecular and Cellular Effectors I [RC] What is New in Retinoblastoma? [AP] AMD Clinical Research 2 [RE ] Retinal Prosthesis and Stem Cells [RE ] Functional Imaging [MOI, AP] 338 339 340 341 342 343 344 345 346 347 348 Session Title Glaucoma Blood Flow [GL] 313 Session Number Glaucoma Surgery I [GL] 312 11am–12:45pm Keratoconus and Collagen Crosslinking [CO] 8:30–10:15am Dry Eye II [CO] Session Title Posters 311 n 310 Session Number Tuesday, May 3 3743 - 3758 3713 - 3742 3688 - 3712 3659 - 3687 3629 - 3658 3617 - 3628 3606 - 3616a 3588 - 3605 3574 - 3587 3540 - 3573 3489 - 3539 Program Number 3371 - 3414 3321 - 3370 3287 - 3320 3239 - 3286a 3201 - 3238 3171 - 3200 3132 - 3170 3102 - 3131 3078 - 3101 3059 - 3077 3046 - 3058 3003 - 3045 2957 - 3002 2923 - 2956 2883 - 2922 2836 - 2882 Program Number D0235 - D0250 D0174 - D0203 D0099 - D0123 C0133 - C0161 B0301 - B0330 B0220 - B0231 B0153 - B0163a B0028 - B0045 B0014 - B0027 A0238 - A0271 A0092 - A0142 Board Number D0308 - D0351 D0124 - D0173 D0029 - D0062 C0039 - C0086a C0001 - C0038 B0271 - B0300 B0232 - B0270 B0107 - B0136 B0065 - B0088 B0046 - B0064 B0001 - B0013 A0352 - A0394 A0306 - A0351 A0272 - A0305 A0143 - A0182 A0045 - A0091 Board Number Glaucoma Visual Fields and Electrophysiology [GL] Accommodation [VI] Clinical Aspects of Refractive Error [CL] Ocular pharmacological and biological applications of nanotechnology [NT] Drug Delivery [PH, RE, LV, VN, RC, MOI, EY] Vitreoretinal Interface Disase [RE ] Melanoma and Lymphoma: from Models to Man [AP] Uveitis Epidemiology [IM, CL] Macular Edema Clinical and Translational [RE ] Müller Cells and Astrocytes In Development and Disease [RC, GL, LE, NT] Clinical and Other Applications of OCT [MOI, AP] 376 377 378 379 380 381 382 383 384 385 4216 - 4272 4185 - 4215 4149 - 4184 4121 - 4148 4088 - 4120 4042 - 4087 3997 - 4041 3986 - 3996 3970 - 3985 3952 - 3969 3897 - 3951 3853 - 3896 Program Number D0251 - D0307 D0204 - D0234 D0063 - D0098 D0001 - D0028 C0162 - C0194 C0087 - C0132 B0175 - B0219 B0164 - B0174 B0137 - B0152 B0089 - B0106 A0183 - A0237 A0001 - A0044 Board Number 2:45–3:45pm: All Posters and Networking — authors will be present at poster boards 1–2:30pm: MIT Outstanding Poster Award Competition (Room 2AB) Poster board numbers correspond to poster location in Exhibit Hall A = Poster Area A , B = Poster Area B , C = Poster Area C and D =Poster Area D Ocular Surface Health and Disease [CO] 375 Session Title 374 Session Number 3:45–5:30pm NOTES _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ _____________________________________________________________________________________________________________ 202 Tuesday – Papers/Minisymposium – 2772 – 2789 Room 6A Room 6B Tuesday, May 03, 2016 8:30 AM-10:15 AM Tuesday, May 03, 2016 8:30 AM-10:15 AM Anatomy and Pathology/Oncology / Glaucoma / Nanotechnology and Regenerative Medicine / Physiology/Pharmacology / Retina Glaucoma 301 Fluids inside and around the eyes in ocular health and pathologies Minisymposium Fluid dynamics inside and around the eye affect multiple aspects of eye health and disease. This symposium will share how fluids maintain a healthy eye environment, how their disruption can contribute to disease, and how we can harness their power for therapeutics. Moderators: Yeni H. Yucel and Shahar Frenkel 2773 — 8:47 Fluid shifts in microgravity: The visual impairment and intracranial pressure syndrome in U.S. astronauts. Christian Otto. Division of Space Life Sciences, Universities Space Research Association, Houston, TX; Human Research Program, NASA Johnson Space Center, Houston, TX 2774 — 9:04 What has genomics taught us about aqueous humor dynamics, cerebral spinal fluid dynamics and ocular perfusion pressure? Louis R. Pasquale. Harvard Medical School, Boston, MA *CR 2775 — 9:21 Pharmacokinetics of Chemotherapy Delivery for Retinoblastoma. David H. Abramson. Memorial Sloan Kettering Cancer, New York, NY; Ophthalmology, Weill Cornell Medical School, New York, NY 2776 — 9:38 Drug delivery for ocular surface malignancies. Jacob Pe’er. Hadassah-Hebrew Univ Med Ctr, Jerusalem, Israel 2777 — 9:55 Fluidics: Drivers for selective drug delivery into the eye. Uday B. Kompella. University of Colorado Denver, Aurora, CO *CR Moderators: Adriana Di Polo and Keith R. Martin 2778 — 8:30 The yin and yang of the complement cascade in glaucoma - the importance of timing and location. Gareth R. Howell1, P. Williams1, J. Harder1, J. Tribble2, K. Pepper1, S. Cross2, P. Morgan2, J. E. Morgan2, S. W. John1. 1The Jackson Laboratory, Bar Harbor, ME; 2 Cardiff University, Cardiff, United Kingdom 2779 — 8:45 Soluble Fas ligand provides long-term protection in a chronic mouse model of glaucoma by inhibiting glial activation, inflammation, and apoptosis. Meredith S. Gregory-Ksander1, 2, F. Fei1, 2, A. MarshakRothstein3, B. Ksander1, 2, A. Krishnan1, 2. 1Schepens Eye Research Institute, Mass Eye & Ear Infirmary, Boston, MA; 2Ophthalmology, Harvard Medical School, Boston, MA; 3Medicine, University of Massachusetts Medical School, Worcester, MA 2780 — 9:00 Müller glial cell-specific GDNF expression promotes retinal ganglion cell survival in DBA/2J mice. Anna M. Demetriades1, C. Pan1, L. C. Byrne2, E. Ahmed1, J. Harder3, S. W. John3, J. G. Flannery2. 1Weill Cornell Medicine, New York, NY; 2University of California, Berkeley, Berkeley, CA; 3The Jackson Laboratory, Bar Harbor, ME 2781 — 9:15 Citicoline preserves optic nerve integrity and visuomotor function following chronic intraocular pressure elevation. Yolandi van der Merwe1, 2, X. Yang1, 3, L. C. Ho1, 4, Y. Yu5, Y. Chau5, C. K. Leung6, 7, I. P. Conner2, 3, M. B. Steketee3, G. Wollstein2, 3, J. S. Schuman2, 3, K. C. Chan1, 3. 1Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, PA; 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; 3UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 4Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China; 5Division of Biomedical Engineering, Hong Kong University of Science and Technology, Hong Kong, China; 6University Eye Center, Hong Kong Eye Hospital, Hong Kong, China; 7Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China *CR 2782 — 9:30 AMP-activated protein kinase, a conserved energy biosensor, signals early neuronal pathogenesis in glaucoma through inhibition of the mammalian target of rapamycin. Nicolas A. Belforte, J. L. Cueva Vargas, A. Di Polo. Neuroscience, University of Montreal Hospital Research Center, Montreal, QC, Canada 2784 — 10:00 Ocular hypertension induces early mitochondrial alterations in retinal endothelial cells in a murine glaucoma model. Yoko Ito2, A. M. Wilson1, C. Vande Velde2, P. Sapieha1, A. Di Polo2.1Ophthalmology and Visual Science, University of Montreal, Montreal, QC, Canada; 2Neuroscience, CRCHUM (University of Montreal), Montreal, QC, Canada Room 6C Tuesday, May 03, 2016 8:30 AM-10:15 AM Retina 303 Imaging the ocular circulation Minisymposium New technologies for imaging the ocular circulation are poised to revolutionize are approach to studying these disorders and managing patients. This symposium provides a comprehensive review of the most promising new approaches for assessing the ocular circulation with a particular focus on OCT angiography. Moderators: Philip J. Rosenfeld and Richard F. Spaide 2785 — 8:30 Adaptive Optics Scanning Light Ophthalmoscopy Microangiography. Richard B. Rosen. Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY; Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY *CR 2786 — 8:40 Understanding of inflammatory and non-inflammatory choroidal thickening using laser speckle flowgraphy. Susumu Ishida. Hokkaido Univ Grad Sch of Med, Sapporo, Japan 2787 — 8:50 En Face OCT Measurement of the Ocular Circulation. David Huang. Oregon Health & Science Univ, Portland, OR *CR 2788 — 9:00 OCTA - overview of the technology and outlook for the future. James G. Fujimoto. Electrical Engineering and Computer Science, Massachusetts Insttitute of Technology, Cambridge, MA *CR 2789 — 9:10 Quantitative flow assessments with OCT Angiography. Johannes F. De Boer. Physics and Astronomy, VU Amsterdam, Amsterdam, Netherlands *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 203 Tuesday Papers/ Minisymposium 8:30 am – 10:15 am 2772 — 8:30 Aqueous humor dynamics in health and disease. Carol B. Toris. Case Western Reserve University, Cleveland, OH; University of Nebraska Medical Center, Ophthalmology and Visual Sciences, Omaha, NE 302 Glaucoma Neuroprotection 2783 — 9:45 Improved neuronal survival after intravitreal injection of an α-synuclein antibody in a glaucoma animal model. Julia Teister, F. Anders, V. Prokosch, S. Beck, S. Funke, C. Manicam, A. Gericke, N. Pfeiffer, F. H. Grus. Ophthalmology, University Medical Center, Mainz, Mainz, Germany 2790 – 2809 – Tuesday – Papers/Minisymposium 2790 — 9:20 Noninvasive visualization and analysis of the human parafoveal capillary network using swept source OCT optical microangiography. Srinivas R. Sadda. University of California - Los Angeles, Los Angeles, CA; Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA *CR 2791 — 9:30 OCTA in retinal vascular diseases. Nadia K. Waheed. New England Eye Center/Tufts University, Boston, MA *CR 2792 — 9:40 Imaging Choroidal Neovascularization with OCTA. David Sarraf. Stein Eye Institute, Los Angeles, CA; Ophthalmology, UCLA, Los Angeles, CA *CR 2793 — 9:50 OCTA in atrophic maculopathies. Giovanni Staurenghi. University of Milan, Milano, Italy *CR — 10:00 Discussion Tuesday Papers/ Minisymposium 8:30 am – 10:15 am Room 606/607 Tuesday, May 03, 2016 8:30 AM-10:15 AM Cornea 304 Ocular Surface Neovascularization, Innervation, and Immunology Moderators: Pedram Hamrah and Mark Rosenblatt 2794 — 8:30 Corneal Sub-Basal Nerve Plexus Density in Parkinson’s Disease. Hannah Kersten1, S. Misra1, R. H. Roxburgh2, H. V. Danesh-Meyer1, C. N. McGhee1. 1Ophthalmology, University of Auckland, Auckland, New Zealand; 2Neurology, Auckland City Hospital, Auckland, New Zealand 2795 — 8:45 Reversibility of diet-induced corneal degeneration in a mouse model. Aubrey Hargrave1, M. Chintalapati2, P. Mehta2, P. Landry1, S. Magadi1, C. W. Smith2, A. R. Burns1. 1College of Optometry, University of Houston, Houston, TX; 2 Pediatric-Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 2796 — 9:00 Relationships between central corneal nerve parameters and tear neuropeptides. Fiona Stapleton1, C. Chao1, 2, I. Jalbert1, P. S. Mandathara1, S. Kolanu1, M. D. Willcox1, M. Markoulli1, J. You3, 1, J. Kim1, E. Lum1, B. Golebiowski1. 1Optometry and Vision Science, University of New South Wales, Kensington Sydney, NSW, Australia; 2College of Optometry, State University of New York, New York, NY; 3 Save Sight Institute, Sydney University, Sydney, NSW, Australia 2797 — 9:15 Pathological lymphangiogenesis is regulated by galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways. Wei-Sheng Chen, Z. Cao, S. Sugaya, M. J. Lopez, V. Sendra, N. V. Laver, P. Hamrah, N. A. Panjwani. Ophthalmology, Tufts University, Boston, MA 2798 — 9:30 Cholinergic regulation of dendritic cell uptake and immune response to topically applied antigens to the conjunctiva. Stephen C. Pflugfelder, C. S. De Paiva, T. G. Coursey, F. L. Barbosa. Ophthalmology, Baylor College of Medicine, Houston, TX 2799 — 9:45 The ocular surface phenotype of Spdef -/- mice: Accumulation of debris but lack of infection upon challenge with Pseudomonas aeruginosa. Ilene K. Gipson, S. Spurr-Michaud, A. Tisdale, B. B. Menon. Ophthalmology, Schepens Eye Research Inst/MEEI, Boston, MA 2800 — 10:00 Infrared thermography used to provide evidence for the pre-ocular tear film being a fluid shell. Thomas J. Millar, B. Schuett. School of Science and Health, Western Sydney University, Penrith, NSW, Australia Room 611/612 Tuesday, May 03, 2016 8:30 AM-10:15 AM 2805 — 9:30 Individual inner retinal neurons imaged in the living eye of monkey and human. Ethan A. Rossi1, R. Sharma1, C. Granger1, 2, C. Schwarz1, Q. Yang1, J. J. Hunter1, 3, D. R. Williams1, 2. 1Center for Visual Science, University of Rochester, Rochester, NY; 2The Institute of Optics, University of Rochester, Rochester, NY; 3 Ophthalmology, Flaum Eye Institute, Rochester, NY *CR 2806 — 9:45 Label Free Imaging of Ganglion Cells in the Living Mouse Eye. Jesse B. Schallek1, 2, A. Joseph3, 2, A. Guevara-Torres3, 2. 1 Flaum Eye Institute, University of Rochester, Rochester, NY; 2Center for Visual Science, University of Rochester, Rochester, NY; 3The Institute of Optics, University of Rochester, Rochester, NY *CR 2807 — 10:00 Measuring organelle motility in RPE cells in the living human retina. Zhuolin Liu, K. Kurokawa, O. P. Kocaoglu, F. Zhang, D. T. Miller. optometry school, Indiana University, Bloomington, IN *CR Visual Psychophysics/Physiological Optics 305 AO Imaging Room 615/617 Moderators: Nicole M. Putnam and Donald T. Miller 2801 — 8:30 Aging, age-related macular degeneration, and the neural economy hypothesis. Ann E. Elsner, J. A. Papay, K. D. Johnston, B. King, S. L. Polster, T. Y. Chui, S. A. Burns. Optometry, Indiana University, Bloomington, IN 2802 — 8:45 Modeling the Relationship Between Foveal Cone Density and Outer Segment Length. Melissa A. Wilk1, R. F. Cooper2, 4, B. M. Wilk3, C. S. Langlo1, J. Carroll1, 3. 1 Cell Biology, Neurobiology, & Anatomy, Medical College of Wisconsin, Hartford, WI; 2Psychology, University of Pennsylvania, Philadelphia, PA; 3 Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 4Ophthalmology, University of Pennsylvania, Philadelphia, PA 2803 — 9:00 Contiguous mapping of retinal pigment epithelium (RPE) cell morphometry across the horizontal meridian of the living human eye. Charles Granger1, 2, H. Song2, Q. Yang2, K. Saito3, K. Nozato3, D. R. Williams1, 2, M. M. Chung2, 4, E. A. Rossi2. 1The Institute of Optics, University of Rochester, Rochester, NY; 2Center for Visual Science, University of Rochester, Rochester, NY; 3Canon U.S.A. Inc., Melville, NY;4Flaum Eye Institute, University of Rochester, Rochester, NY *CR 2804 — 9:15 Imaging Photoreceptor Shedding in the Living Human Eye. Omer P. Kocaoglu, Z. Liu, K. Kurokawa, D. T. Miller. School of Optometry, Indiana University, Bloomington, IN Tuesday, May 03, 2016 8:30 AM-10:15 AM Cornea 306 Cornea Endothelium Moderators: Ula V. Jurkunas and Noriko Koizumi 2808 — 8:30 New evidence suggesting that the central endothelium presents features of peripheral endothelium in Fuchs endothelial corneal dystrophy. Zhiguo HE1, P. Gain1, A. S. Jun2, F. Forest1, 3, L. Kallay2, J. Dumollard3, F. Bergandi4, M. Peoc’h3, G. Thuret1, 5. 1Corneal Graft Biology, Engineering and Imaging Laboratory, EA2521, Jean Monnet University, Saint Etienne, France; 2Cornea, Cataract, and Refractive Surgery Services, Wilmer Eye Institute/Johns Hopkins Medical Institutions, Baltimore, MD; 3Department of Pathology, University Hospital of Saint-Etienne, Saint Etienne, France; 4Department of Anatomy, Jean Monnet University, Saint Etienne, France; 5 Institut Universitaire de France, Paris, France 2809 — 8:45 Trinucleotide repeat expansion and TCF4 gene expression in Fuchs endothelial corneal dystrophy. Keisuke Ogata1, N. Okumura1, R. Hayashi1, M. Nakahara1, M. Nakano2, K. Tashiro2, S. Kinoshita3, U. Schlötzer-Schrehardt4, T. Tourtas4, F. E. Kruse4, N. Koizumi1. 1Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan; 2Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan; 3Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Department of Ophthalmology, University of ErlangenNürnberg, Erlangen-Nuremberg, Germany The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 204 Tuesday – Papers/Minisymposium – 2810 – 2824 2810 — 9:00 UV-A Irradiation Induced Mouse Model of Fuchs Endothelial Corneal Dystrophy. Cailing Liu1, T. Miyai1, D. Vojnovic1, I. E. Kochevar2, U. V. Jurkunas1. 1Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA; 2Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 2811 — 9:15 Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy. Naoki Okumura1, K. Hashimoto1, M. Kitahara1, M. Nakahara1, S. Kinoshita2, T. Tourtas3, U. Schlötzer-Schrehardt3, F. E. Kruse3, N. Koizumi1. 1 Doshisha University, Kyotanabe, Japan; 2Kyoto Prefectural University of Medicine, Kyoto, Japan; 3 University of Erlangen-Nürnberg, Erlangen, Germany *CR 2813 — 9:45 Functional gene transfer for antiapoptotic therapy of corneal endothelial cells - a magnetofection approach. Marta Czugala3, O. Mykhaylyk1, A. K. Gruenert3, F. E. Kruse3, S. Wesselborg2, C. Plank1, T. A. Fuchsluger3. 1 Institute of Experimental Oncology, Technical University Munich, Munich, Germany; 2Institute of Molecular Medicine I, University Hospital Düsseldorf, Düsseldorf, Germany; 3Department of Ophthalmology, University Erlangen-Nurnberg, Erlangen, Germany 2814 — 10:00 Corneal Endothelial Pump Is Dependent on Buffering Lactic Acid Efflux. Joseph A. Bonanno, E. Kim, S. Li. School of Optometry, Indiana University, Bloomington, IN Tuesday, May 03, 2016 8:30 AM-10:15 AM Retinal Cell Biology 307 Stem Cells: Disease Models and Therapeutics I Moderators: Valeria Canto Soler and David M. Gamm 2815 — 8:30 Endogenous expression of mutant BEST1 results in decreased Cl- and Ca2+ conductance in human retinal pigment epithelium. Michael D. O’Connor, M. Mangala, M. Cameron, J. Morley. School of Medicine, Western Sydney University, Penrith, NSW, Australia 2816 — 8:45 Human embryonic stem cell-derived retinal pigment epithelial cells functionally integrate and rescue photoreceptors in a large-eyed model of geographic atrophy. Sandra Petrus-Reurer1, 2, A. Plaza Reyes2, L. Antonsson2, S. Stenfelt2, H. Bartuma1, S. Panula2, H. Andre1, O. Hovatta2, F. Lanner2, A. P. Kvanta1. 1 Clinical Neuroscience, Section for Ophtalmology and Vision, Karolinska Institutet, St. Erik Eye Hospital, Stockholm, Sweden; 2Department of Clinical Sciences, Intervention and Technology, Karolinska Insitutet, Stockholm, Sweden 2817 — 9:00 Exogenous factors induce rod and cone photoreceptor-specific progenitors from adult mouse retinal stem cells. Brian G. Ballios1, S. Khalili2, K. Grise2, L. Donaldson3, G. Bernier4, M. Shoichet5, V. Wallace1, 6, D. van der Kooy2. 1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; 2Molecular Genetics, University of Toronto, Toronto, ON, Canada; 3Division of Ophthalmology, McMaster University, Hamilton, ON, Canada; 4Maisonneuve-Rosemont Hospital, Centre de recherché, Université de Montréal, Montréal, ON, Canada; 5Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada; 6Vision Science Research Program, Toronto Western Hospital, Toronto, ON, Canada 2818 — 9:15 Human Stem Cell Derived Retinal Spheroids Characterized Non-Invasively for Structure and Function by Multimodal Imaging. Andrew Browne2, 1, C. Arnesano3, T. Kuu4, H. Pollack4, R. Moats4, L. Thomas4, 2, J. Aparicio4, S. Fraser3, 4, D. Cobrinik4, 2. 1Ophthalmology, Cleveland Clinic, Cole Eye Institute, Cleveland, OH; 2Ophthalmology, University of Southern California, Los Angeles, CA; 3Department of Biomedical Engineering, University of Southern California, Los Angeles, CA; 4Children’s Hospital of Los Angeles, Los Angeles, CA *CR 2819 — 9:30 Patient-specific iPSCs to investigate pathophysiology and develop treatments for RPGR-associated XLRP. Joseph C. Giacalone, E. R. Burnight, T. P. Sharma, L. A. Wiley, D. Ochoa, M. Collins, R. F. Mullins, B. A. Tucker, E. M. Stone. Department of Ophthalmology & Visual Sciences, Stephen A. Wynn Institute for Vision Research, Carver College of Medicine, University of Iowa, Iowa City, IA 2820 — 9:45 Gene-edited human induced pluripotent stem cell derived 3D retinas for the systematic optimization of retinal cup formation by small molecule screening. Karl J. Wahlin2, S. R. Sripathi1, K. Eldred3, J. Heng4, R. Johnston3, C. Berlinicke1, D. J. Zack1. 1Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD; 2 Ophthalmology, University of California, San Diego, LaJolla, CA; 3Biology, Johns Hopkins University, Baltimore, MD; 4Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 2821 — 10:00 The effect of human embryonic stem cell-derived extracellular vesicles (hESEVs) on Müller cells and their potential use for retinal regeneration. Debora B. Farber. Ophthalmology, Stein Eye Institute/UCLA, Los Angeles, CA Room Tahoma 3, TCC Tuesday, May 03, 2016 8:30 AM-10:15 AM Clinical/Epidemiologic Research 308 THC, Telehealth and Trichiasis: A CL potpourri Moderators: Ingrid E. Zimmer-Galler and Anand Vinekar 2822 — 8:30 Time requirements for ophthalmology documentation with electronic health records (EHRs): a time-motion and big data study. Sarah Read-Brown, M. R. Hribar, J. Wallace, L. G. Reznick, T. Yackel, M. F. Chiang. Oregon Health & Science University, Portland, OR *CR 2823 — 8:45 Teleophthalmology in a Community Setting to Improve Eye Health Among Latinos: A Paradigm Shift. Judy E. Kim1, V. Medic1, A. Castro2, B. Rodriguez2, M. Bonet2, M. DeNomie3, Z. Franco3, V. Bilen4, S. Cho1, S. Ahamed4. 1Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 2United Community Center, Milwaukee, WI; 3Medical College of Wisconsin, Milwaukee, WI; 4Marquette University, Milwaukee, WI *CR 2824 — 9:00 Institutional Quality Improvement for American Board of Ophthalmology Maintenance of Certification. Jennifer Weizer1, G. Greenberg2, V. Harrison2, T. Blachley1, P. P. Lee1. 1Kellogg Eye Center, University of Michigan, Ann Arbor, MI; 2University of MIchigan, Ann Arbor, MI f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 205 Tuesday Papers/ Minisymposium 8:30 am – 10:15 am 2812 — 9:30 Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells. Shigeru Kinoshita2, M. Ueno1, K. Asada2, M. Toda2, K. Nagata4, C. Sotozono1, N. Kosaka3, T. Ochiya3, J. Hamuro1. 1 Ophthalmology, Kyoto Prefectural Univ of Med, Kamigyo-Ku, Japan; 2Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan; 3Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan; 4Toray Inc., Kamakura, Japan *CR Room Tahoma 1/2, TCC 2825- – 2835 – Tuesday – Papers/Minisymposium 2825 — 9:15 Increased Incidence of Glaucoma Diagnosis Following Passage of Medical Marijuana Legislation. David S. Sanders2, J. R. Ehrlich2, T. Blachley2, T. Cooney2, J. D. Stein2, 1. 1Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI; 2Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI Tuesday Papers/ Minisymposium 8:30 am – 10:15 am 2826 — 9:30 Study of Knowledge, Attitudes and Practices Related to Eye Diseases in the Southern Indian States of Andhra Pradesh and Telangana. Srinivasa Pallerla. School of Optometry, university of New South Wales, Hyderabad, India; Andhra Pradseh Right To Sight Society, Hyderabad, India 2827 — 9:45 Surgical Simulation in Lowresource Settings Improves Intra-operative Aspects of Trichiasis Surgery Training. Emily W. Gower1, 2, A. B. Kello3, M. Kollmann4, J. Johnson5. 1 Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC; 2Ophthalmology, Wake Forest School of Medicine, Winston Salem, ND; 3Light For the World, Addis Ababa, Ethiopia; 4 CBM, Nairobi, Kenya; 5Wake Forest Innovations, Winston-Salem, NC *CR 2828 — 10:00 Barriers to accessing surgery for trachomatis trichiasis in Kongwa, Tanzania. Ryan J. Bickley1, H. Mkocha2, B. E. Munoz1, S. K. West1. 1Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 2 Kongwa Trachoma Project, Kongwa, United Republic of Tanzania Room Tahoma 5, TCC Tuesday, May 03, 2016 8:30 AM-10:15 AM Visual Neuroscience 2831 — 9:00 Rod photoreceptors mediate light-evoked activity of dopaminergic amacrine cells across a wide range of light intensities. Xiwu Zhao2, 1, S. Qiao2, 3, Y. Zhong3, K. Y. Wong1, D. Zhang2.1Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, MI; 2Eye Research Institute, Oakland University, Rochester, MI; 3Institute of Neurobiology, Fudan University, Shanghai, China 2832 — 9:15 The absence of complexin 3 alters rod bipolar cell pathway function. Joshua H. Singer1, L. S. Mortensen4, S. J. Park2, J. Ke1, L. Zhang1, N. Brose4, J. Rhee4, J. B. Demb2, 3. 1 Biology, University of Maryland, College Park, MD; 2Ophthalmology, Yale University, New Haven, CT; 3Cellular and Molecular Physiology, Yale University, New Haven, CT; 4AG Synapse Physiology, Max-Planck-Institute of Experimental Medicine, Göttingen, Germany 2833 — 9:30 Calcium signaling at Cx36 gap junctions in the mouse retina. John O’Brien1, Y. Lin1, W. Kothmann2, 3, K. B. Moore1, C. K. Mitchell1, J. S. Diamond2. 1Ophthalmology, Univ of Texas Houston Med Sch, Houston, TX; 2NINDS, Bethesda, MD; 3American University, Washington, DC 2834 — 9:45 Connectomics of irradianceencoding ON bipolar-cell inputs to ipRGCs. Shai Sabbah1, M. Kim1, G. Manoff1, A. Bhatia-Lin1, C. Papendorp1, K. Briggman2, D. M. Berson1. 1 Neuroscience, Brown University, Providence, RI; 2 National Institute for Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 2835 — 10:00 Postnatal development of rod bipolar cell dendrites in mouse retina. Ivan Anastassov, F. Dunn. Ophthalmology, University of California San Francisco, San Francisco, CA 309 Bipolar, Horizontal and Amacrine cells Moderators: Joshua H. Singer and Catherine W. Morgans 2829 — 8:30 Quantification of the neurons in the rod pathway of human retina. Sammy C. Lee, R. J. Aghajani, P. R. Martin, U. Grunert. Save Sight Institute - Department of Ophthalmology, University of Sydney, Sydney, NSW, Australia 2830 — 8:45 Cone photoreceptors generate inhibitory ON and OFF responses in dopamingergic amacrine cells via distinct OFF pathways. Sheng-Nan Qiao1, 2, Y. Zhong2, D. Zhang1. 1Eye Research Institute, Oakland University, Rochester, MI; 2Institute of Neurobiology, Fudan University, Shanghai, China The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 206 Tuesday – Posters – 2836 – 2856 Exhibit/Poster Hall A0045-A0091 Tuesday, May 03, 2016 8:30 AM-10:15 AM Cornea 310 Dry Eye II Moderator: Penny A. Asbell 2836 — A0045 Difference in tear meniscus between conjunctivochalasis eyes and normal eyes using anterior segment optical coherence tomography. Kanako Kimura, Y. Takamura, M. Gozawa, S. Yokota, T. Matsumura, M. Inatani. Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Yoshida, Fukui, Japan 2837 — A0046 Objective Measurement of Eyelash Parameters and their Relation to Dry Eye Disease. John D. Rodriguez1, P. Corcoran1, E. Angjeli1, C. Sundstrom1, G. W. Ousler2. 1Research and Development, Ora Institute, Andover, MA; 2Dry Eye, Ora, Inc., Andover, MA *CR 2839 — A0048 Sleep disturbance is associated with dry eye syndrome in a rural population in Korea : Study group for Environmental Eye Disease (SEED). Hyungseon Yeom1, N. Kim2, J. Song3, H. Lee4, H. Kim1. 1Department of Preventive Medicine, Yonsei University School of Medicine, Seoul, Korea (the Republic of); 2Department of Public Health, Yonsei University Graduate School, Seoul, Korea (the Republic of); 3Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea (the Republic of); 4Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (the Republic of) 2840 — A0049 Sleep disorders in dry eye disease and allied irritating ocular diseases. Masahiko Ayaki, M. Kawashima, K. Negishi, T. Kishimoto, M. Mimura, K. Tsubota. Keio University, Tokyo, Japan 2841 — A0050 Clinical characteristics of dry eye patients with depression. Jelle Vehof1, 2, N. Sillevis Smitt - Kamminga1, C. J. Hammond2. 1 Ophthalmology, University Medical Center Groningen, Groningen, Netherlands; 2Twin research and genetic epidemiology, King’s College London, London, United Kingdom 2842 — A0051 Impact of Clinically Significant Dry Eye on Self-Reported Driving Performance. Priya M. Mathews, S. Karakus, P. Y. Ramulu, E. K. Akpek. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD *CR 2850 — A0059 Repeatability of Ocular Surface Cooling Measurement. Wing Li1, 2, A. D. Graham2, M. C. Lin1, 2. 1Vision Science Graduate Group, University of California, Berkeley, CA; 2Clinical Research Center, School of Optometry, University of California, Berkeley, CA 2844 — A0053 Baseline Characteristics in the Dry Eye Assessment and Management (DREAM) Study. Milton M. Hom. Optometry, Private Practice, Azusa, CA *CR, f 2852 — A0061 The Efficacy of Strip Meniscometry and DEQS for Dry Eye Screening during Medical Health checkups. Sho Ishikawa1, N. Kato1, M. Takeuchi2. 1Ophthalmology, Saitama Medical University, Moroyama, Japan; 2 Opthalmology, National Defence Medical Collage, Tokorozawa, Japan 2845 — A0054 Objective Signs Correlate With Subjective Symptoms in Dry Eye (DE). William H. Ridder, E. Borsting, P. Yoshinaga, H. V. Ha, S. Ridder. Southern California College of Optometry, Marshall B. Ketchum University, Cypress, CA 2846 — A0055 Dermatological alterations in Dry Eye Disease. Rossen M. Hazarbassanov1, N. Queiroz-Hazarbassanov2, L. M. VasquezPinto3, M. M. Amaral3, J. P. Gomes1, M. Campos1. 1 Ophthalmology and Visual Sciences, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil; 2Pathology Department, School of Veterinary Medicine and Animal Sciences, Sao Paulo, Brazil; 3Natura Product Technology, Cajamar, Brazil *CR 2847 — A0056 Correlation between corneal changes by confocal microscopy and symptomatology in patients with dry eye syndromes. Tudor Tepelus1, G. B. Chiu2, J. Huang1, P. Huang1, S. R. Sadda1, 3, O. L. Lee1, 3. 1 Ophthalmology, Doheny Image Readind Center/ Doheny Eye Institute, Los Angeles, CA; 2USC Eye Institute, Keck School of Medicine, Los Angeles, CA; 3UCLA Department of Ophthalmology/David Geffen School of Medicine, Doheny Eye Center, Los Angeles, CA *CR 2848 — A0057 Pain In Dry-Eye Patients Without Corresponding Clinical Signs - A Retrospective Analysis. Philipp Steven1, 4, T. Schneider1, 4, I. Ramesh2, S. E. Siebelmann1, 4, U. Gehlsen1, 4, J. Loeser3, D. Spohn3. 1Ophthalmology, University of Cologne, Cologne, Germany; 2 Psychosomatic Medicine, University of Cologne, Cologne, Germany; 3Anaesthesiology and Intensive Care Medicine, University of Cologne, Cologne, Germany;4Cluster of Excellence: Cellular Stress Responses in Aging-associated Disease (CECAD), University of Cologne, Cologne, Germany 2849 — A0058 Effects of experimental tear film instability on sensory responses to corneal cold, mechanical and chemical stimuli. Ping Situ1, T. L. Simpson2, C. G. Begley1. 1School of Optometry, Indiana University Bloomington, Bloomington, IN; 2School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada 2851 — A0060 Ocular Surface Thermal Imaging Pre- and Post-CAESM. Christian Sundstrom1, K. J. Lane1, E. Angjeli1, P. Corcoran1, G. W. Ousler2. 1Research and Development, Ora,Inc., Andover, MA; 2Dry Eye, Ora, Inc., Andover, MA *CR 2853 — A0062 Identification of dry eye subtypes by tear interferometry. Reiko Arita1, 7, N. Morishige2, 7, T. Fujii3, 7, S. Fukuoka6, 7, J. Chung4, K. Seo5, Y. Fukuda1, K. Itoh1. 1Itoh Clinic, Saitama, Japan;2Ophthalmology, Yamaguchi University, Ube, Japan; 3Development, Kowa, Tokyo, Japan; 4 Ophthalmology, Kim’s Eye Hospital, Konyang University, Seoul, Korea (the Republic of); 5 Ophthalmology, Yonsei University college of medicine, Seoul, Korea (the Republic of); 6Omiya Hamada Ophthalmic Clinic, Saitama, Japan; 7Lid and Meibomian Gland Working Group, Toko, Japan *CR 2854 — A0063 Altered sub-basal nerve plexus, increased dendritic cells, differential cytokine profile and associated vitamin D deficiency explains pain in evaporative dry eye (EDE). Rashmi Deshmukh1, R. shetty1, A. Agrawal1, A. Ghosh2, R. Shroff1. 1Cornea and Refractive Services, Narayana Nethralya, Bangalore, India; 2 Narayana Nethralaya Foundation, GROW Research Laboratory, Bangalore, India 2855 — A0064 A Comparison of SPEED Scores in Contact Lens and Non-Contact Lens Wearers. Andrew D. Pucker1, L. Jones-Jordan1, J. T. Kwan2, C. Kunnen4, S. Srinivasan3. 1College of Optometry, The Ohio State University, Columbus, OH; 2Southern California College of Optometry, Marshall B Ketchum, Fullerton, CA; 3School of Optometry and Vision, University of Waterloo, Waterloo, ON, Canada; 4College of Optometry, University of Houston, Houston, TX *CR 2856 — A0065 Isotretinoin Study: Ocular Surface Comparison between Exposed and Unexposed Groups. Thao N. Yeh2, 1, M. C. Lin2, 1. 1 Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA; 2Clinical Research Center, School of Optometry, University of California, Berkeley, Berkeley, CA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 207 Tuesday Posters 8:30 am – 10:15 am 2838 — A0047 Discomfort over Time Associated with various Ocular Demodex Treatment Products. William Ngo1, L. W. Jones1, S. Srinivasan1, E. Bitton2. 1University of Waterloo, Waterloo, ON, Canada;2University of Montreal, Montreal, QC, Canada *CR 2843 — A0052 Dry Eye Symptoms and Visual Function with Digital Device Use. Jennifer Harthan1, L. O’Dell6, 2, J. T. Kwan3, M. M. Hom7, S. G. Hauswirth8, A. Schachter4, 9, S. Schachter4, 9, W. Hauser5, A. Kabat5. 1Illinois College of Optometry, Chicago, IL; 2Adjunct Clinical Faculty, Salus University, Elkins Park, PA; 3Marshall B. Ketchum University, Fullerton, CA; 4Adjunct Clinical Faculty, SCCO, Fullerton, CA; 5Southern College of Optometry, Memphis, TN; 6Private Practice, York, PA; 7Private Practice, Azusa, CA; 8Private Practice, Bloomington, MN; 9Private Practice, Pismo Beach, CA *CR 2857 – 2874 – Tuesday – Posters 2857 — A0066 Development of the 2-item Daily Ocular Symptoms Survey to assess day-to-day fluctuations in discomfort and dryness. Archana Boga, B. Golebiowski, F. Stapleton. Optometry, University of New South Wales, Sydney, NSW, Australia Tuesday Posters 8:30 am – 10:15 am 2858 — A0067 Ocular Surface Thermal Imaging in Normal and Dry Eye Subjects. Michael Watson1, K. J. Lane2, E. Angjeli2, P. Corcoran2, J. D. Rodriguez2, G. W. Ousler1. 1Dry Eye, Ora, Inc., Andover, MA;2Research and Development, Ora, Inc., Andover, MA *CR 2859 — A0068 Clinical findings of Dry Eye Disease in a large Norwegian cohort based on osmolarity measurements. Sjur Reppe1, X. Chen3, 4, S. Ræder3, 4, T. P. Utheim2, 5, Ø. A. Utheim2, A. Stojanovic4, 8, N. S. Lagali6, D. A. Dartt7, B. Tashbayev3. 1Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; 2 Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; 3The Norwegian Dry Eye Clinic, Oslo, Norway; 4Synslaser Surgery AS, Oslo, Norway; 5Department of Ophthalmology, Vestre Viken Hospital Trust, Drammen, Norway; 6 Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden;7Department of Ophthalmology, Harvard Medical School, Boston, MA; 8Eye Department, University Hospital North Norway, Tromsø, Norway 2860 — A0069 Prevalence of hyperosmolarity and symptoms of DED in the US population. Venkiteshwar S. Manoj. Medical Affairs, TearLab Corporation, Seattle, WA *CR 2861 — A0070 Tear Cytokine Biomarkers in Dry Eye Patients Subjected to Environmental Stress and Treated with Topical 0.1% Fluorometholone. Margarita Calonge1, 2, J. Pinto-Fraga1, 2, A. Enriquez-De-Salamanca1, 2, I. Fernández2, 1, M. J. González-García1, 2, A. LópezMiguel1, 3, A. López-de-la-Rosa1, R. W. Beuerman4, 5, V. L. Calder6, M. E. Stern7. 1Ophthalmology, IOBAUniversity of Valladolid, Valladolid, Spain;2CIBERBBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Madrid, Spain; 3VISION I+D, SL, Valladolid, Spain; 4SILK, Department of Ophthalmology, University of Tampere, Tampere, Finland; 5 Singapore Eye Research Institute, Singapore, Singapore; 6University College London, UCL, London, United Kingdom; 7Allergan Inc., Irvine, CA *CR, f 2862 — A0071 Effect of punctal occlusion on blinks in eyes with severe aqueous tear deficient dry eye. Hiroaki Kato1, N. Yokoi1, R. Sakai1, M. Niu1, A. Watanabe1, S. Kinoshita2, C. Sotozono1. 1 Department of Ophthalmology, Kyoto Prefectural Univ of Medcine, Kyoto City Kamigyoku, Japan; 2 Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural Univ of Medicine, Kyoto, Japan *CR 2863 — A0072 Environmental nitration of ocular lactoferrin may contribute to dry eye disease. Amani Y. Alhalwani1, 2, J. E. Repine2, J. A. Huffman1. 1Chemistry and biochemistry, University of Denver, Englewood, CO; 2Webb-Waring Center, University of Colorado School of Medicine, Denver, CO 2864 — A0073 Randomized, controlled, crossover trial comparing the impact of sham or intranasal neurostimulation on conjunctival goblet cell degranulation. Koray Gumus1, 3, K. Schuetzle1, J. D. Loudin2, S. C. Pflugfelder1. 1Cullen Eye Institute, Baylor College of Medicine, Houston, TX; 2Allergan (Oculeve), South San Francisco, CA; 3 Department of Ophthalmology, Erciyes University School of Medicine, Kayseri, Turkey *CR, f 2865 — A0074 Safety and efficacy of ciclosporin 1 mg/mL cationic emulsion (CsA CE) over 12 months in patients with severe dry eye disease (DED) in the SANSIKA Phase III trial. Gysbert B. Van Setten1, F. C. Figueiredo2, A. Leonardi3, M. Amrane4, J. Garrigue4, D. Ismail4, C. Baudouin5, 6. 1St Eriks Eye Hospital, Karolinska Inst/St Eriks Eye Hosp, Danderyd, Sweden; 2Royal Victoria Infirmary, Newcastle University, Newcastle upon Tyne, United Kingdom; 3Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy; 4Santen SAS, Evry, France; 5 Quinze-Vingts National Ophthalmology Hospital, Paris, France; 6UPMC University, Paris, France Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France *CR, f 2866 — A0075 Prospective, randomized trial of the two mucin secretogogues for the treatment of dry eye in office workers. Jun Shimazaki1, S. Den-Shimazaki2, M. Saga3, K. Fukagawa4, 6, M. Sakata5, M. Iwasaki4, T. Okano7. 1Ophthalmology, Tokyo Dental College, Ichikawa, Japan; 2Shimazaki Eye Cloinic, Tokyo, Japan; 3Ichikawa Shapo Eye Clinic, Ichikawa, Japan; 4Ryogoku Eye Clinic, Tokyo, Japan; 5Shinjuku Eye Clinic, Tokyo, Japan; 6 Iidabashi Eye Clinic, Tokyo, Japan; 7Smile Eye Clinic, Yokohama, Japan *CR, f 2867 — A0076 Clinical Effects and Safety of 3% Diquafosol Ophthalmic Solution for Patients with Dry Eye after Cataract Surgery. Dae Hyun Park, J. Chung, S. Lee. Ophthalmology, Soonchunhyang University Hospital, Seoul, Korea (the Republic of) f 2868 — A0077 The effect of topical rebamipide on environmental stress induced dry eye in the wild type mice. Takashi Kojima1, 2, O. M. Ibrahim2, T. Inaba2, S. Nakamura2, M. Dogru2, K. Tsubota2.1Ophthalmology, Gifu Red Cross Hospital, Nagoya, Japan; 2Ophthalmology, Keio University School of Medicine, Tokyo, Japan *CR 2869 — A0078 The effect of 3% diquafosol sodium eye drops on the meibomian gland alterations of the superoxide dismutase-1 knockout mice. Keisuke Ikeda1, 2, M. Dogru2, 1, M. Kawashima1, T. Kojima1, K. Higa2, A. Igarashi2, T. Yamaguchi2, S. Den-Shimazaki2, K. Tsubota1, J. Shimazaki2. 1Keio University School of Medicine, Tokyo, Japan; 2Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan *CR 2870 — A0079 Effect of 2% rebamipide ophthalmic suspension in dry eye rabbit model. Hiroshi Toshida1, T. Ohta1, C. Suto2, K. Shinji3, M. Karasawa3, A. Murakami3. 1Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Japan; 2Ophthalmology, Saiseikai Kurihashi Hospital, Saitama, Japan; 3Ophthalmology, Juntendo University, Tokyo, Japan *CR 2871 — A0080 Pooling of two randomized Phase III clinical trials of ciclosporin 1 mg/ mL cationic emulsion (CsA CE) as a treatment for severe keratitis in patients with dry eye disease (DED). Elisabeth Messmer1, A. Leonardi2, M. Amrane3, D. Ismail3, F. C. Figueiredo4, C. Baudouin5, 6. 1Department of Ophthalmology, Ludwig-Maximilian-University Munich, München, Germany; 2Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy; 3Santen SAS, Evry, France; 4Royal Victoria Infirmary, Newcastle University, Newcastle upon Tyne, United Kingdom; 5Quinze-Vingts National Ophthalmology Hospital, Paris, France; 6UPMC University, Paris 6, Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France *CR, f 2872 — A0081 A Multi-Center Phase 3 Safety and Tolerability Study of Isunakinra (EBI-005) in Subjects with Moderate to Severe Dry Eye Disease. Leontia Burke3, M. H. Goldstein1, 2, K. L. Tubridy1.1Development, Eleven Biotherapeutics, Cambridge, MA; 2New England Eye Center, Tufts Medical Center, Boston, MA; 3Clinical Operations, Eleven Biotherapeutics, Cambridge, MA *CR, f 2873 — A0082 The effect of TRPM8-agonist menthol eyedrops on tear meniscus area and height. Peter Corcoran2, E. Angjeli2, K. J. Lane2, G. W. Ousler3, M. Watson3, M. B. Abelson1, 4. 1 Ophthalmology, Ora, Inc, Andover, MA; 2Research and Development, Ora Institute, Andover, MA; 3 Dry Eye, Ora, Inc, Andover, MA; 4Ophthalmology, Harvard Medical School, Boston, MA *CR 2874 — A0083 A Phase 3 Multi-Center, Randomized Controlled Evaluation of the Efficacy, Safety and Tolerability of Isunakinra in Subjects with Moderate to Severe Dry Eye Disease. Karen L. Tubridy, PharmD, 1 Michael H. Goldstein, MD, 1,2 Marianne Magill, MS 1. 1 Eleven Biotherapeutics (Cambridge, MA) 2 New England Eye Center, Tufts Medical Center (Boston, MA). Karen L. Tubridy1, M. H. Goldstein1, 2, M. Magill3. 1 Development, Eleven Biotherapeutics, Cambridge, MA; 2New England Eye Center, Tuft’s Medical Center, Boston, MA; 3Consultant, Natick, MA *CR, f The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 208 Tuesday – Posters – 2875 – 2892 2875 — A0084 Safety, Tolerability and Pharmacokinetics of P-321 Ophthalmic Solution in Subjects with Mild to Moderate Dry Eye Disease. Jose L. Boyer1, A. Woodring1, J. Ansede1, W. Thelin1, M. R. Johnson1, K. N. Sall2, G. N. Foulks3, R. C. Boucher4. 1Parion Sciences, Durham, NC; 2Sall Research Medical Center, Artesia, CA; 3University of Louisville, Louisville, KY; 4 University of North Carolina, Chapel Hill, NC *CR, f 2877 — A0086 Efficacy of Topical Application of a Transient Receptor Potential Melastatin 8 Agonist in Patients with Dry Eye. Kyung Chul Yoon1, J. Yang1, Y. Kang1, L. Cui1, 2, Y. Li1, 2, H. Lee1, I. You3.1Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea (the Republic of); 2 Department of Biomedical Science and Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, Korea (the Republic of); 3 Department of Ophthalmology, Chonbuk National University College of Medicine, Jeonju, Korea (the Republic of) f 2878 — A0087 Results of clinical trials with a novel RNA-based therapy (SYL1001) to treat patients with ocular pain associated to dry eye disease. Ana Isabel Jimenez1, J. M. Benitez Del Castillo3, 8, J. Moreno-Montanes2, 8, I. JimenezAlfaro7, F. Muñoz-Negrete6, 8, K. Palumaa4, K. Turman5, C. Paneda1, T. Martinez1, V. Ruz1, V. Gonzalez1. 1Ophthalmology, Sylentis, Madrid, Spain; 2Clinica Universidad Navarra, Pamplona, Spain; 3Hospital Clínico San Carlos, Madrid, Spain; 4 East-Tallinn Central Hospital Eye Clinic, Madrid, Spain; 5Eye Clinic Dr. Krista Turman, Tallin, Estonia; 6Hospital Ramón y Cajal, Madrid, Spain; 7 Fundación Jiménez Díaz, Madrid, Spain; 8Oftared, Madrid, Spain *CR, f 2879 — A0088 Clinical comparison of gel-type artificial tears. Joseph G. Vehige2, M. M. Hom1, P. A. Simmons2, D. A. Hollander2. 1Private Practice, Azusa, CA; 2Allergan, Plc, Dublin, Ireland *CR, f 2881 — A0090 Effect of gel-based artificial tears on tear film thickness in patients with dry eye disease. Doreen Schmidl1, 2, K. Witkowska1, 2, R. M. Werkmeister2, P. Wozniak1, A. Bata1, K. Fondi1, C. Baar1, G. Garhofer1, L. Schmetterer1, 2. 1 Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; 2Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria f 2882 — A0091 Clinical Evaluation of Schirmer Test Variations on the Predictability of Benefit from Artificial Tears. Matthew Young1, H. Zhong2, E. Peterson2, E. Patel2, D. Schwartz1, Y. Michael1, C. Leffler1. 1Ophthalmology, Virginia Commonwealth University, North Chesterfield, VA; 2Virginia Commonwealth University School of Medicine, Richmond, VA Exhibit/Poster Hall A0143-A0182 Tuesday, May 03, 2016 8:30 AM-10:15 AM Cornea 311 Keratoconus and Collagen Crosslinking Moderators: May Griffith and Mark Yorek 2883 — A0143 Same Day vs. Sequential CK+CXL in the Treatment of Ectasia. Olivia Dryjski1, R. Rubinfeld2, 1, R. Lindstrom6, D. Kim2, M. Choi2, S. Shetty3, R. Ambrosio5, A. Cummings4. 1 Ophthalmology, Medstar Georgetown University Hospital/Washington Hospital Center, Washington, DC; 2Ophthalmology, Re:Vision Private Practice, Washington, DC; 3Ophthalmology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY; 4Wellington Eye Clinic, Beacon Hospital, Dublin, Ireland; 5Instituto de Olhos Renato Ambrosio, Rio de Janeiro, Brazil; 6 Ophthalmology, Minnesota Eye Consultants, University of Minnesota, Minneapolis, MN *CR, f 2884 — A0144 Monitoring of O2 concentrations during Corneal Cross-Linking (CXL) by Phosphorescence Lifetime Imaging Microscopy (PLIM). Rebecca M. McQuaid1, M. C. Mrochen3, R. Dmitriev2, D. Papkovski2, B. Vohnsen1. 1 Ophthalmology, Univ Coll Dublin/IROC Innocross, Dublin, Ireland; 2School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland; 3Ophthalmology, IROC Science AG, Zurich, Switzerland 2885 — A0145 Corneal Collagen Crosslinking and Intracorneal Ring Segments: Simultaneous vs Sequential Surgery. Reda Issa1, P. S. Hersh1, S. Greenstein2. 1Ophthalmology, Rutgers University - New Jersey Medical School, Newark, NJ; 2 Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA f 2886 — A0146 Corneal Cross-Linking Before Intrastromal Ring Segment Implantation Decreases The Effectiveness Of The Rings. Lucia Ibares-Frias1, 2, P. Gallego1, 3, R. Cantalapiedra3, G. G. Gonçalves de Almeida Cunha3, J. MerayoLloves1, 4, M. Martínez-García1, 3. 1Group of Optical Diagnostic Techniques, University of Valladolid, Valladolid, Spain; 2Ophthalmology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; 3 Cellular Biology, Histology and Pharmacology Department, Faculty of Medicine, University of Valladolid, Valladolid, Spain; 4Instituto Universitario Oftalmológico Fernandez-Vega, Oviedo, Spain 2887 — A0147 Corneal endothelial loss after corneal crosslinking for keratoconus. Naoko Kato1, 2, M. Shinzawa2, K. Konomi2, K. Kasai2, 3, J. Shimazaki2. 1Department of Ophthalmology, Saitama Medical University, Saitama, Japan; 2 Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan; 3Department of Ophthalmology, Jikei University, Tokyo, Japan *CR, f 2888 — A0148 Biocompatible Chondroitin sulfate-based cross-linker restores corneal mechanics and collagen alignment. Xiaokun Wang, J. Sohn, G. Ma, S. C. Yiu, J. Elisseeff. ophthalmology, Johns Hopkins University, Baltimore, MD 2889 — A0149 Effect of Epithelial Removal on the Corneal Curvature in Keratoconic Eyes prior to Crosslinking. Michael W. Belin1, J. C. Siordia2. 1 Ophthalmology, University of Arizona, Marana, AZ; 2University of Arizona, Tucson, AZ *CR 2890 — A0150 One-year outcomes of changes in corneal densitometry after accelerated (45mW/cm2) transepithelial corneal collagen cross-linking for keratoconus. Yang Shen, W. Jian, L. Sun, M. Li, T. Han, M. Tian, X. Zhou. Eye and ENT Hospital of Fudan University, Shanghai, China 2891 — A0151 Freiburg keratoconus registry: Implementation and first findings of a monocentric keratoconus registry. Stefan J. Lang, D. Boehringer, T. Reinhard. Eye Center, AlbertLudwigs-University of Freiburg, Freiburg, Germany 2892 — A0152 Preliminary Results Of A Randomized Controlled Trial Comparing Transepithelial Corneal Cross-Linking With Iontophoresis And Standard Cross-Linking In Patients With Progressive Keratoconus. sebastiano serrao1, G. Lombardo2, M. Rosati1, D. schiano lomoriello1, M. Lombardo1. 1Fondazione Bietti Roma, Rome, Italy; 2Consiglio Nazionale delle Ricerche, Istituto per i Processi ChimicoFisici, Messina, Italy f f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 209 Tuesday Posters 8:30 am – 10:15 am 2876 — A0085 Topical ocular ciclosporin 1 mg/ mL cationic emulsion in patients with dry eye with severe keratitis: Experience through the French early access program. Serge Doan1, P. Pisella2, 3, B. Cochener4, M. Amrane5, D. Ismail5, C. Baudouin6, 7, M. Labetoulle8. 1Ophthalmology, Bichat Hospital & A de Rothschild Foundation, Paris, France; 2University François Rabelais, Tours, France; 3Department of Ophthalmology, Bretonneau Hospital, Tours, France; 4Brest University Medical School, Morvan Hospital, Brest, France; 5Santen SAS, Evry, France; 6Quinze-Vingts National Ophthalmology Hospital, Paris, France; 7UPMC University, Paris 6, Vision Institute, INSERM UMRS968, CNRS UMR7210, Paris, France; 8 Department of Ophthalmology, Bicêtre Hospital, APHP, Paris-Sud University, Le Kremlin-Bicêtre, France *CR, f 2880 — A0089 Fingerprick Autologous Blood as a Novel Treatment for Dry Eye Syndrome and Persistent Epithelial Defects. Jonathan Y. Than1, J. Wawrzynski1, J. Moore2, A. Patel3, S. Shah4, N. Nesaratnam1, A. Sharma1. 1Moorfields Eye Centre at Bedford Hospital, London, United Kingdom; 2 The Royal Victoria Hospital, Belfast, United Kingdom; 3Heart of England NHS Foundation Trust, Birmingham, United Kingdom;4Birmingham and Midland Eye Centre at City Hospital, Birmingham, United Kingdom f 2893 – 2917 – Tuesday – Posters 2893 — A0153 Non invasive label free hyperspectral method to assess corneal crosslinking efficacy. Giuseppe Lombardo1, V. Villari1, N. Micali1, N. Leone1, M. Lombardo2. 1IPCF, CNR, Messina, Italy;2IRCCS Fondazione G.B. Bietti, Rome, Italy *CR 2894 — A0154 Correlation Between Eye Rubbing And Keratoconus Severity In A Treatment-Naive Keratoconic Population. Mohamed Zaidi, L. Lhuillier, N. Ouamara, C. Goetz, N. Houmad, S. Maxime, A. ehrhardt, J. Perone, O. Guechi, A. Agapie, P. Krawczyk. Ophtalmology, Regional Hospital of Metz Thionville (France), Metz, France Tuesday Posters 8:30 am – 10:15 am 2895 — A0155 Ultrastructural Study of lamellar organization of Peripheral and Central Stroma of Keratoconus Cornea. Aljoharah Alkanaan2, 1, O. Kirat3, R. Barsotti2, T. Almubrad1, A. Khan1, S. Akhtar1.1King Saud University, Riyadh, Saudi Arabia; 2Salus University, Philadelphia, PA; 3 King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia 2896 — A0156 A pilot study of corneal sensitivity and its associations in keratoconus. Preeji S. Mandathara1, F. Stapleton1, J. Kokkinakis1, 2, M. D. Willcox1. 1School of Optometry and Vision Science, University of New South Wales, Randwick, NSW, Australia; 2The Eye Practice, Sydney, NSW, Australia 2897 — A0157 Determining the Efficacy of Corneal Cross-linking (CXL) Protocols for Different Corneal Thicknesses: Theoretical Model and Experimental Validation. Sabine Kling1, 2, F. Hafezi2, 3.1Laboratory of Ocular Cell Biology, University of Zurich, Zurich, Switzerland; 2 University of Geneva, Geneva, Switzerland; 3 ELZA Institute, Dietikon/Zurich, Switzerland 2898 — A0158 Four-year results of riboflavin ultraviolet-A corneal collagen cross-linking for progressive corneal ectasia in 129 eyes. Samar A. Al-Swailem, S. Al Zaid. King Khaled Eye Specialist Hosp, Riyadh, Saudi Arabia 2899 — A0159 Relationship between repeatability in corneal topography parameters and increased disease severity in keratoconic eyes. Ciara Bergin, F. Majo, K. Hashemi, I. Guber. Ophthalmology, Jules-Gonin Eye Hosptial, Lausanne, Switzerland 2900 — A0160 Keratoconus is not attributable to eye rubbing in a young Down’s syndrome cohort. Stephanie Campbell, J. Woodhouse, K. Meek. Cardiff Centre for Vision Sciences, Cardiff University, Cardiff, United Kingdom 2901 — A0161 Stromal demarcation line: is it predictive for Cross-Linking efficiency? Louis Lhuillier1, N. Houmad1, M. Zaidi1, S. Maxime1, A. Ehrhardt1, A. Agapie1, O. Guechi1, P. Krawczyk1, H. Duong Nguyen Viet2, 1, J. Perone1. 1Ophthalmology, CHR Metz, Metz, France; 2Hoang Quoc Hung Hospital, Hô Chi Minh ville, Viet Nam 2902 — A0162 Correlation of Anterior and Posterior Corneal Shape in Clinical Keratoconus. Jaime Larrea Gonzalez1, A. J. Ramirez-Miranda1, A. Navas1, E. O. GraueHernandez1, A. Jimenez-Corona2.1Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico; 2Research & Evaluation, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico 2903 — A0163 To differentiating keratoconus and contact lens-related corneal warpage by combining pattern analysis of focal changes in anterior corneal topography, pachymetry, and epithelial thickness maps. Maolong Tang, Y. Li, D. Huang. Oregon Health and Science University, Portland, OR *CR 2904 — A0164 Outcome Of Implantable Collamer Lens In Keratoconus. Salem G. Almalki. Ophathalmology, King Khalid Eye Specialist Hospital, Riaydh, Saudi Arabia 2905 — A0165 Is keratoconus risk associated with genetic variation of aldehyde dehydrogenase ALDH3A1 gene? Piotr Krawczyk1, 2, J. Perone1, A. ambroziak2, J. giebultowicz2, O. Guechi1, A. agapie1, N. Ouamara1, L. Lhuillier1, N. Houmad1, H. Duong Nguyen Viet3, J. szaflik2. 1ophthalmology, Regional hospital center, Mercy hospital, METZ cedex 03, France; 2ophthalmology, Medical University of Warsaw, Warsaw, Poland;3University of Medicine and Pharmacy of Ho Chi Minh City, Ho Chi Minh City, Viet Nam 2910 — A0170 Corneal Collagen Crosslinking for progressive keratoconus: a prognosis factor analysis. Everardo Hernandez-Quintela, M. CostaGonzález, N. Ramos Betancourt, M. Ramirez, J. D. Martinez, V. Sánchez-Huerta. Cornea and Refractive Surgery, Asociación para Evitar la Ceguera en México, Hospital “Dr. Luis Sánchez Bulnes”, Mexico City, Mexico 2911 — A0171 NC-1059 peptide-assisted transepithelial riboflavin penetration in an exvivo rabbit corneal model. Daniel M. Gore3, P. French1, D. O’Brart2, C. Dunsby1, B. D. Allan3. 1 Physics Department, Imperial College, London, United Kingdom; 2Ophthalmology, St. Thomas’ Hospital, London, United Kingdom; 3External Disease Service, Moorfields Eye Hospital, London, United Kingdom *CR 2912 — A0172 Alterations to Bowman’s layer and local molecular deregulation driving focal corneal weakening: new evidence towards Keratoconus etiopathogenesis. Natasha Pahuja1, N. R. Kumar2, R. SHROFF1, R. shetty1, A. Sinha Roy2, A. Ghosh2. 1Cornea-Refractive, Narayana Nethralaya, Pune, India; 2Narayana Nethralaya, Bangalore, India *CR, f 2913 — A0173 Characteristics of corneal astigmatism of anterior and posterior surface in healthy individuals and keratoconus patients. Ingo Schmack, G. Shajari, M. PourSadeghian, M. Remy, F. Hengerer, T. Kohnen. Ophthalmology, Goethe-University, Frankfurt, Germany 2906 — A0166 Hair cortisol analysis in progressive and stable keratoconus patients. Janine Lenk, E. Spoerl, L. E. Pillunat, F. Raiskup. Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany 2914 — A0174 The role of Transforming growth factor beta 2 (TGF-beta 2) in the pathogenesis of keratoconus. Omer Iqbal, W. Brambl, C. Bouchard. Ophthalmology, Loyola University Chicago, Maywood, IL 2907 — A0167 Collagen arrangement from Second Harmonic Microscopy in corneas following cross-linking. James Germann, E. Martinez-Enriquez, S. Marcos. Instituto de Óptica, CSIC, Madrid, Spain 2915 — A0175 In-vivo Penetration of WST11 to the Corneal Stroma using Dextran with Various Molecular Weights. Arie Marcovich1, 2, A. Brandis1, I. Samish1, I. Pinkas1, I. Feine1, A. Goz1, 2, Y. Salomon3, A. Scherz1. 1Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel; 2Ophthalmology, Kaplan Medical Center, Rehovot, Israel; 3Biological Regulation, Weizmann Institute of Science, Rehovot, Israel *CR 2908 — A0168 An ex vivo investigation into the effect of accelerated crosslinking using pulsed and continuous UVA irradiation modes on corneal enzymatic resistance. Nada H. Aldahlawi1, S. Hayes1, D. P. O’Brart2, A. Akhbanbetova1, S. L. Littlechild1, K. M. Meek1. 1School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; 2Department of Ophthalmology, Keratoconus Research Institute St Thomas Hospital, London, United Kingdom 2909 — A0169 Is topography guided crosslinking the next stage in the evolution of crosslinking: Refractive, keratometric and biomechanical outcomes. Aarti Agrawal1, N. Pahuja1, R. shetty1, A. Ghosh2, A. Sinha Roy2. 1 Cataract and refracrive surgery, Narayana Nethralaya, Mumbai, India; 2Narayana Netharalaya, Bangalore, India *CR 2916 — A0176 Functional And Anatomical Modifications In A Six-Month Follow-up Of Patients Treated With Collagen Cross-linking. Riccardo Scotto, D. Musetti, F. Licata, C. E. Traverso. DiNOGMI, University of Genoa, Genova, Italy 2917 — A0177 Trans-Epithelial Accelerated Corneal Cross-linking for Keratoconus in Children: 18 month follow-up. Alejandro Navas, A. Olivo-Payne, A. Abdala, E. Hernandez-Bogantes, A. J. Ramirez-Miranda, E. O. Graue-Hernandez. Instituto de Oftalmologia - Catarata, Institute of Ophthalmology “Conde de Valenciana”, Mexico City, Mexico The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 210 Tuesday – Posters – 2918– 2937 2918 — A0178 Health-Related Quality of Life Improvement in Keratoconic Patients Subjected to the Athens Protocol Treatment. Ioannis Datseris1, G. Asimellis2, 3, A. J. Kanellopoulos3, 4. 1 OMMA Surgical, Athens, Greece; 2Kentucky College of Optometry, Pikeville, KY; 3LaserVision. gr Clinical & Research Eye Institute, Athens, Greece; 4 Ophthalmology, NY University, NY, NY *CR 2919 — A0179 The persistence of pain relief after corneal crosslinking in mild bullous keratopathy eyes. Takashi Ono1, Y. Terada2, Y. Mori1, R. Nejima1, M. Ogata1, K. Minami1, K. Miyata1. 1Miyata Eye Hospital, Miyakonojo, Japan; 2 Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan 2920 — A0180 Correlation between central stromal demarcation line depth and flattening of the cornea after corneal cross-linking comparing two different treatment protocols. Niklas Pircher, A. Gschliesser, R. Donner, J. Lammer, G. Schmidinger. Ophthalmology, Medical University of Vienna, Wien, Austria 2922 — A0182 Trans-epithelial and Stromal Pulsed-Light Accelerated Corneal Cross-linking for Patients with Progressive Keratoconus. Andrew Olivo-Payne, A. Abdala, E. HernandezBogantes, A. J. Ramirez-Miranda, A. Navas, D. Loya, E. O. Graue-Hernandez. Department of Ophthalmology, Instituto de Oftalmologia Conde de Valenciana, Mexico City, Mexico Exhibit/Poster Hall A0272-A0305 Tuesday, May 03, 2016 8:30 AM-10:15 AM Glaucoma 312 Glaucoma Surgery I Moderators: Beth Edmunds, Leonard Seibold and Mark R. Lesk 2923 — A0272 Cell adhesion and protein adsorption studies of 3D printed photopolymers. Richard M. Lee1, 2, M. Alband2, M. Penny2, S. T. Hilton2, S. Brocchini1, 2, P. T. Khaw1. 1National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom; 2UCL School of Pharmacy, London, United Kingdom 2925 — A0274 Collagen VIII and XI as Biomarkers for Post-operative Conjunctival Fibrosis. Tina T. Wong2, 3, L. Toh2, S. Chu2, J. Chua1, L. Seet2, 3. 1Singapore National Eye Centre, Singapore National Eye Centre, Singapore, Singapore; 2Ocular Therapeutics and Drug Delivery, Singapore Eye Research Institute, Singapore, Singapore; 3Duke NUS Medical School, Singapore, Singapore 2926 — A0275 Utility of purified collagenase (Xiaflex®) as a possible aid in glaucoma surgery: A pilot study. Robert A. Honkanen1, K. Kaplowitz1, E. Yung1, A. G. Fong1, J. P. Wright2. 1 Ophthalmology, SUNY Stony Brook, Stony Brook, NY; 2School of Medicine, Stony Brook University, Stony Brook, NY *CR 2927 — A0276 Novel MRTF/SRF inhibitors prevent conjunctival scarring after glaucoma filtration surgery: An ex vivo and in vivo study. Cynthia Yu-Wai-Man3, R. M. Lee3, S. Larsen1, R. Neubig2, P. T. Khaw3. 1Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, MI; 2Department of Pharmacology and Toxicology, Michigan State University, MI; 3 National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom 2928 — A0277 Effects of rho-associated protein kinase inhibitor Y-27632 on scarring formation after glaucoma filtration surgery. Hideaki Okumichi, W. Iwata, S. Okimoto, J. Ko, Y. Kiuchi. Department of Ophthalmology and Visual Science, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan 2929 — A0278 Effects of ripasudil (K-115), a Rho kinase inhibitor, on the activation of human conjunctival fibroblasts. Akiko Futakuchi, T. Inoue, T. Fujimoto, M. M. Inoue, H. Tanihara. Ophthalmology, Kumamoto University Hospital, Chuo-ku, Kumamoto city, Japan *CR 2930 — A0279 Anti-fibrotic effect of a multilayered nanoparticle system for delivery of siSPARC in a mouse model of experimental glaucoma surgery. Yang Fei Tan1, 2, L. Seet2, L. Toh2, S. Venkatraman1, T. T. Wong2, 1. 1Nanyang Technological University, Singapore, Singapore; 2 Singapore Eye Research Institute, Singapore, Singapore 2931 — A0280 The antiproliferative effect of bevacizumab on human tenon fibroblasts is presumably not through VEGF inhibition. Charlotte Fischer, V. Mans, N. Feltgen, H. Hoerauf, C. van Oterendorp. Ophthalmology, University medicine Goettingen, Germany, Goettingen, Germany 2932 — A0281 Lipid nanoemulsion associated with paclitaxel as a new antiscarring agent in experimental glaucoma surgery. Vital P. Costa1, M. Occhiutto1, F. R. Freitas2, P. Picciarelli2, R. Maranhao2.1Ophthalmology, University of Campinas, Sao Paulo, Brazil; 2INCOR, University of Sao Paulo, Sao Paulo, Brazil *CR 2933 — A0282 Effects of gelatin hydrogel containing transforming growth factor-β antibody in a canine filtration surgery model. Michiko Miki1, S. Kojima1, T. Sugiyama2, D. Jin3, S. Takai3, R. Kohmoto1, M. Ueki1, T. Ikeda1. 1 ophthalmology, Osaka Medical College, Takatsukicity, Japan; 2Nakano Eye Clinic, Kyoto, Japan; 3 Pharmacology, Osaka Medical College, Takatsuki, Japan 2934 — A0283 Effect of Uveitis Activity on Surgical Outcomes in Uveitic Glaucoma. Hye Jin Kwon1, 2, W. L. Tao1, L. L. Lim1, 2, J. G. Crowston1, 2, J. Ruddle1, 2, G. Y. Kong1, 2. 1Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia; 2 Department of Ophthalmology, Centre for Eye Research, East Melbourne, VIC, Australia 2935 — A0284 Subconjunctival injection vs surgical sponge application of mitomycin-C (MMC) during trabeculectomy in a county clinic. Mallika Doss1, 2, A. Z. Chuang1, L. Blieden1, 2. 1Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center (UTHealth) McGovern Medical School, Houston, TX; 2Robert Cizik Eye Clinic, Houston, TX 2936 — A0285 Comparison of intraoperative injection of Mitomycin (MMC) versus conventional sponge-applied MMC during double site phaco-trabeculectomy. Vivek Pullutipadath Sasikumar1, S. Reich2, M. Pillai1, A. Kanathia1, S. Priya1, P. S1, J. Serle2. 1Aravind Eye Center, India, India; 2Ophthalmology, Icahn School of Medicine of Mount Sinai Hospital, New York, NY *CR, f 2937 — A0286 Does type of postoperative antiglaucoma drug affect morphological changes of filtering bleb after trabeculectomy? - Utilizing the data from the Collaborative Bleb-Related Infection Incidence and Treatment Study. Yuji Yamamoto1, K. Mori1, I. Yokota2, Y. Ikeda1, M. Ueno1, K. Imai1, H. Yoshikawa1, S. Teramukai2, S. Kinoshita1, C. Sotozono1. 1Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2 Biostatistics, Kyoto Prefectural University of Medicine, Kyoto, Japan f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 211 Tuesday Posters 8:30 am – 10:15 am 2921 — A0181 Progression after corneal crosslinking in keratoconus eyes with KMax≥58.0 D. Samuel J. Küchler1, C. Tappeiner1, D. Epstein2, B. E. Frueh1. 1Ophthalmology, University Hospital Berne, Berne, Switzerland; 2Private Practice, Berne, Switzerland 2924 — A0273 Conjunctival tissue proteome demonstrates abnormal expression of wound response proteins in glaucoma patients. Hannu M. Uusitalo1, 2, A. Jylhä1, J. Nättinen1, 3, A. Vaajanen2, M. Härkönen2, M. Nykter3, L. Zhou4, R. W. Beuerman1, 4. 1Ophthalmology, SILK, PPM, University of Tampere, Tampere, Finland; 2Tays Eye Center, Tampere University Hospital, Tampere, Finland; 3BioMediTech, University of Tampere, Tampere, Finland; 4SERI, Singapore, Singapore 2938 – 2958 – Tuesday – Posters 2938 — A0287 Safety and Efficacy of Trabeculectomy with Mitomycin C Injection. Sze H. Wong1, S. M. Walsman2, 1, A. S. Khouri1. 1Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ; 2Hudson Eye Physicians and Surgeons, Jersey City, NJ 2939 — A0288 Non-penetrating deep sclerectomy versus trabeculectomy for open angle glaucoma in Mexican population. David Berrones Medina, A. Hernández-Vargas, J. JimenezArroyo, A. Castillejos- Chévez, J. Jiménez-Roman. Ophthalmology, Asociación para Evitar la Ceguera en Mexico, Mexico City, Mexico 2940 — A0289 Attaining intraocular pressure of 10 mmHg or less: a comparison of tube and trabeculectomy surgery in eyes with pseudophakic glaucoma and initial glaucoma surgery. Alissa Meyer, K. Harbie, C. Rodgers, N. Rosenberg, M. B. Sherwood. Ophthalmology, University of Florida, Gainesville, FL Tuesday Posters 8:30 am – 10:15 am 2941 — A0290 Changes in Cup-to-Disc Ratio Following Trabeculectomy. Cassie N. Confait, O. Idowu, M. Moroux. Ophthalmology, University of Mississippi Medical Center, Madison, MS 2942 — A0291 Aberrometric changes induced by trabeculectomy performed in an Argentinian teaching hospital. Pablo R. Ruisenor Vazquez, J. F. Casiraghi. Glaucoma Section, Ophthalmology Division, Hospital de Clínicas, University of Buenos Aires, Capital Federal, Argentina 2943 — A0292 Toric intraocular lens in patients with glaucoma undergoing phacoemulsification and trabeculectomy: two years follow-up. Yael Azses, A. Garcés-Valencia, C. Prado Larrea, R. Castañeda Diez, J. Jiménez-Roman. Asociación para evitar la ceguera en México, Mexico City, Mexico 2944 — A0293 Long-term outcomes of trabeculectomy in contact lens wearers. Jose A. Paczka1, 2, L. A. Giorgi-Sandoval2, 3, A. OrozcoGarcía4, 2. 1Institute of Ophthalmology and Visual Sciences, University of Guadalajara, Guadalajara, Mexico; 2Research, Unidad de Diagnostico Temprano del Glaucoma, Guadalajara, Mexico; 3 Research, Asistencia e Investigacion en Glaucoma, Guadalajara, Mexico; 4Ophthalmology, Antiguo Hospital Civil de Guadalajara, Guadalajara, Mexico 2945 — A0294 Risk of Surgical Failure in Patients with Hypotony after Trabeculectomy. Carole H. Kim1, V. L. Tseng1, 2, P. Romero1, F. Yu1, 3, J. Caprioli1, H. Quarry1, A. L. Coleman1, 2. 1 Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA; 3Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA *CR 2946 — A0295 Effect and Risk Factor for Failure of Trabeculectomy in the Glaucoma Patients with Low Baseline Intraocular Pressure in the Collaborative Bleb-Related Infection Incidence and Treatment Study. Yosuke Miyoshi1, H. Sakata1, Y. Kiuchi1, Y. Sugimoto2, Y. Murakami3, T. Higashide4, K. Sugiyama4. 1Ophthalmology, Hiroahima University Hospital, Hiroshima, Japan; 2 Ophthalmology, Hiroshima Prefectural Hospital, Hiroshima, Japan; 3Ophthalmology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Hiroshima, Japan; 4Ophthalmology, Kanazawa University Hospital, Kanazawa, Japan 2947 — A0296 Early Postoperative Complications of the Ex-PRESS Implantation versus Trabeculectomy: A Randomized Clinical Trial. Shogo Arimura, Y. Takihara, S. Miyake, K. Iwasaki, M. Gozawa, T. Matsumura, T. Tomomatsu, Y. Takamura, M. Inatani. Ophthalmology, University of Fukui, Fukui, Japan f 2948 — A0297 The evaluation of the safety of a self-assembling peptide gel as a potential device for providing a clear operative field in the trabeculectomy. Kenji Matsushita1, R. Kawashima1, K. Uesugi1, 2, H. Okada2, H. Sakaguchi1, K. Nishida1. 1Ophthalmology, Osaka University Medical School, Suita, Japan; 2Menicon Co., Ltd., Kasugai, Japan *CR 2949 — A0298 Trabeculectomy in Both Eyes; the First-Operated Versus the Second-Operated Eyes: A Comparative, Multicenter Study. Kentaro Iwasaki1, Y. Takamura1, T. Nishida2, A. Sawada2, K. Iwao3, A. Shinmura5, S. Kunimatsu-Sanuki4, H. Tanihara3, K. Sugiyama5, T. Nakazawa4, M. Inatani1. 1 ophthalmology, University of Fukui, Fukui, Japan; 2 University of Gifu, Gifu, Japan; 3University of Kumamoto, Kumamoto, Japan; 4University of Tohoku, Tohoku, Japan; 5University of Kanazawa, Kanazawa, Japan 2950 — A0299 Hypotony Maculopathy after Trabeculectomy. Victoria L. Tseng1, 2, A. L. Coleman1, 2, P. Romero1, F. Yu1, K. W. RobertsonBrown1, J. Caprioli1. 1UCLA/Stein Eye Institute, Los Angeles, CA;2Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA *CR 2951 — A0300 Uveitis, Glaucoma, Hyphema Syndrome: A Referral-Based, Retrospective Analysis. Trevor A. Smith, A. Cheung, J. C. Hart, C. Chen. Ophthalmology, Beaumont Health - Royal Oak, Royal Oak, MI 2952 — A0301 Early post-operative wound leak after trabeculectomy with mitomycin C with and without placement of bandage contact lens. Ingrid Chang, K. D. Bojikian, D. Gupta, P. P. Chen. Ophthalmology, University of Washington, Seattle, WA 2953 — A0302 The effect of trabeculectomy surgery on the central visual field in patients with glaucoma and an established central visual field defect using Micro-perimetry and Optical coherence tomography. Gokulan Ratnarajan1, 2, J. K. Jolly2, 3, J. Salmon2. 1Ophthalmology, Queen Victoria Hospital, Chalfont St Peter, United Kingdom; 2Oxford Eye Hospital, Oxford, United Kingdom; 3Nuffield Laboratory of Ophthalmology, Oxford, United Kingdom f 2954 — A0303 The effect of intraoperative application of chemically defined bioadhesive powder for trabeculectomy in rabbit eyes. Yoshifumi Okamoto1, S. Hoshi1, M. Arai2, G. Kishino1, F. Okamoto1, T. Oshika1. 1University of Tsukuba, Tsukuba, Japan; 2Arai Eye Clinic, Fukuoka, Japan 2955 — A0304 Second Trabeculectomy After Failure of The First Trabeculectomy : Outcomes and Risk Factors for Failure. Pradtana Hirunpatravong, R. Alizadeh, P. Romero, K. NouriMahdavi, J. Caprioli. Ophthalmology, Glaucoma division, JSEI, UCLA, Los Angeles, CA 2956 — A0305 Alteration of lymphatic vessels after filtration surgery in mouse. Akira Matsuda, Y. Asada, S. Iwamoto, J. Sugita. Ophthalmology, Juntendo Univ School of Med, Tokyo, Japan Exhibit/Poster Hall A0306-A0351 Tuesday, May 03, 2016 8:30 AM-10:15 AM Glaucoma 313 Glaucoma Blood Flow Moderators: Yali Jia and Ruikang K. Wang 2957 — A0306 Optic disc perfusion in eyes with primary open angle glaucoma and normal tension glaucoma using optical coherence tomography-based microangiography. Karine D. Bojikian1, C. Chen2, J. C. Wen1, Q. Zhang2, C. Xin2, D. Gupta1, R. C. Mudumbai1, M. A. Johnstone1, R. K. Wang2, 1, P. P. Chen1. 1Ophthalmology, University of Washington, KIRKLAND, WA; 2Bioengineering, University of Washington, Seattle, WA *CR 2958 — A0307 OCT Angiography Vessel Density in Normal, Glaucoma Suspects and Glaucoma Eyes: Structural and Functional Associations in the Diagnostic Innovations in Glaucoma Study (DIGS).Adeleh Yarmohammadi1, L. M. Zangwill1, A. Diniz-Filho1, M. Suh1, 2, P. C. Manalastas1, N. Fatehee1, A. Belghith1, S. Yousefi1, F. A. Medeiros1, R. N. Weinreb1. 1Hamilton Glaucoma Center, Shiley Eye institute, Department of Ophthalmology, University of Callifornia San Diego, La Jolla, CA; 2Inje University, college of medicine, Haeunda Paik Hospital, Busan, Korea (the Republic of) *CR, f The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 212 Tuesday – Posters – 2959 – 2978 2959 — A0308 OCT Angiography of the Optic Nerve Head to differentiate normal from glaucoma eyes. Manuele Michelessi1, G. Manni2, L. Tanga1, M. Ferrazza1, F. Berardo1, G. Roberti1, E. Elmo2, F. Oddone1. 1IRCCS - Fondazione GB Bietti, Rome, Italy; 2University of Rome Tor Vergata, Rome, Italy 2960 — A0309 Comparison of the Optic Disc Microvascular and Structure in Open Angle Glaucoma Patients and Related Factors. Kimikazu Sakaguchi, T. Higashide, S. Udagawa, S. Ohkubo, K. Sugiyama. Dept of Ophthalmology, Kanazawa University, Kanazawa, Japan f 2961 — A0310 Optical coherence tomography angiography in glaucoma. Jens Ulrich Werner, C. Enders, G. K. Lang, G. E. Lang. Department of Ophthalmology, University of Ulm, Ulm, Germany *CR 2963 — A0312 Normalization of Retinal Vessel Density profile in healthy subjects. Ivania Pereira1, 2, H. Resch2, S. Holzer2, F. Schwarzhans1, J. Wu3, G. Fischer1, C. Vass2. 1Center for Medical Statistics Informatics and Intelligent Systems, Section for Medical Information Management and Imaging, Medical University Vienna, Vienna, Austria; 2Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; 3Christian Doppler Labor for Ophthalmic Image Analysis (OPTIMA), Department of Ophthalmology, Medical University of Vienna, Vienna, Austria *CR 2964 — A0313 Evaluation of retinal vessel morphology in Open Angle Glaucoma using a novel Optical Coherence Tomography based method. Robert Kromer1, 3, S. Boelefahr1, A. Bartels2, S. C. Beutelspacher3, M. Klemm1. 1 Department of Ophthalmology, Hamburg Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Vision Systems, Hamburg University of Technology, Hamburg, Germany; 3Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, Medical Faculty Mannheim, Mannheim, Germany 2965 — A0314 Phenotype of a Subgroup of Primary Open Angle Glaucoma Patients with Optic Nerve Susceptibility. Reza Alizadeh, P. Hirunpatravong, P. Romero, J. Caprioli. Glaucoma, Jules Stein Eye Institute, University of California, Los Angeles, CA 2967 — A0316 Association between retinal microcirculation perfusion and retinal thickness at macula region in glaucoma patients: An Optical Coherence Tomography Angiography study. Huan Xu, X. Kong. Ophthalmology and Vision Science, Eye and ENT hospital,Fudan University,Shanghai,China, Shanghai, China 2968 — A0317 Retinal vascular caliber in normal-tension glaucoma patients according to visual field severity. Kojiro Imai2, K. Mori1, Y. Ikeda1, 3, M. Ueno1, H. Yoshikawa1, Y. Maruyama1, Y. Yamamoto1, S. Kinoshita4, C. Sotozono1. 1 Department of Ophthalmology, Kyoto Prefectural Univ of Med, Kyoto, Japan; 2Department for Medical Innovation and Translational Medical Science, Kyoto Prefectural Univ. of Med., Kyoto, Japan;3Oike-Ikeda Eye Clinic, Kyoto, Japan; 4 Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural Univ. of Med., Kyoto, Japan 2969 — A0318 Total retinal blood flow in healthy and glaucomatous human eyes measured with 3 beam Doppler optical coherence tomography. Richard Haindl1, A. Wartak1, W. Trasischker1, 2, B. Baumann1, M. Pircher1, C. K. Hitzenberger1. 1Medical University of Vienna, Vienna, Austria; 2Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 2970 — A0319 Primary angle-closure glaucoma causes significant decrease in both retinal ganglion cell complex thickness and optic nerve blood flow. Hideki Fukuoka, R. N. Weinreb, N. A. Afshari. Shiley Eye Institute, University of California, San Diego, La Jolla, CA 2971 — A0320 Preperimetric glaucoma study 2: The relationship between optic nerve head blood flow and visual field progression in preperimetric glaucoma. Yukihiro Shiga1, N. Aizawa1, S. Tsuda1, K. Omodaka1, Y. Yokoyama1, T. Yasui2, K. Kato3, T. Nakazawa1. 1Ophthalmology, Tohoku University, Sendai, Japan; 2Yasui Eye Clinic, Sendai, Japan; 3Kato Eye Center, Sendai, Japan *CR, f 2972 — A0321 Baseline retrobulbar blood flow velocities correlate more strongly with changes in retinal capillary density over 4 years in open angle glaucoma patients with diabetes mellitus. Casey Seizys1, A. Harris1, A. Verticchio Vercellin2, N. Moore1, A. Huang1, D. WuDunn1, G. Eckert3, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2973 — A0322 Baseline retrobulbar blood flow correlates more strongly with longitudinal changes in macular structure in glaucoma patients of African descent. Alice Chandra Verticchio Vercellin4, A. Harris1, B. A. Siesky1, A. Huang1, C. Ridenour1, I. Januleviciene2, L. Siaudvytyte2, G. Eckert3, N. Moore1, T. A. Ciulla1. 1 Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2Ophthalmology, Lithuanian Univ of Health Sciences, Kaunas, Lithuania; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN; 4University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy *CR 2974 — A0323 Ophthalmic artery blood flow velocities predict functional and structural glaucoma progression after 5 years. Andrew Huck1, A. Harris1, A. Verticchio Vercellin2, N. Moore1, T. J. Knight1, C. C. Frye1, G. Eckert3, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2975 — A0324 Association of optic disc haemorrhages in open angle glaucoma with vascular symptoms. Gregor Thomaschewski, K. R. Pillunat, E. Spoerl, L. E. Pillunat. Ophthalmology, Univ Clinic Carl Gustav Carus Dresden, Dresden, Germany f 2976 — A0325 Systemic and local factors related to optic nerve head blood flow in patients with glaucoma. Yutaro Yamada, T. Higashide, S. Takeshima, S. Udagawa, K. Sugiyama. Kanazawa University, Kanazawa, Japan f 2977 — A0326 Alzheimer’s disease and primary open angle glaucoma may share nailfold capillary abnormalities. Paul A. Knepper1, 2, C. Cousins3, K. Carey1, I. Bielskus1, M. Patel1, N. J. Volpe2, T. Patrianakos4, M. Giovingo4, L. R. Pasquale5, R. Stern3. 1Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 2Ophthalmology, Northwestern University, Chicago, IL; 3Neurology, Boston University, Boston, MA; 4Ophthalmology, John H. Stroger, Jr. Hospital, Chicago, IL; 5Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA *CR 2978 — A0327 Systemic blood and ocular perfusion pressures influence retrobulbar blood flow in open-angle glaucoma patients with diabetes mellitus. Betul Kaskan1, A. Harris1, N. Moore1, A. Verticchio Vercellin2, R. Frantz1, C. Jonescu-Cuypers1, G. Eckert3, B. A. Siesky1. 1 Ophthalmology, Indiana University School of Medicine, Istanbul, Turkey; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 213 Tuesday Posters 8:30 am – 10:15 am 2962 — A0311 OCT Angiography Macular Vessel Density, Ganglion Cell Complex Thickness and Visual Fields in Healthy, Glaucoma Suspect and Glaucomatous Eyes. Naeem Fatehee2, 1, L. M. Zangwill2, 1, A. Diniz-Filho2, 1, A. Yarmohammadi2, 1, M. H. Suh2, 1, P. C. Manalastas2, 1, A. Belghith2, 1, S. Yousefi2, 1, F. A. Medeiros2, 1, R. N. Weinreb2, 1. 1 Shiley Eye Institute, University of California San Diego, La Jolla, CA;2Hamilton Glaucoma Center, La Jolla, CA *CR 2966 — A0315 Correlation between isolated hemifield defects, OCT-based microangiography (OMAG) and the macular vulnerability zone (MZV). Yungtai Kung1, C. Chen1, 2, P. P. Chen1, Q. Zhang1, 2, R. K. Wang1, 2, R. C. Mudumbai1. 1 Ophthalmology, University of Washington, Seattle, WA; 2Bioengineering, University of Washington, Seattle, WA *CR Tuesday Posters 8:30 am – 10:15 am 2979 – 2996 – Tuesday – Posters 2979 — A0328 Diabetic status influences retrobulbar blood flow involvement in glaucomatous functional progression over five years. Colin Ridenour1, A. Harris1, B. A. Siesky1, A. Verticchio Vercellin2, T. J. Knight1, A. Huang1, J. Carr1, G. Eckert3, N. Moore1. 1Ophthalmology, Indiana University School of Medicine, Avon, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2985 — A0334 Lower baseline ophthalmic artery blood flow velocities predict glaucomatous functional progression differently according to gender. Amelia Huang1, A. Harris1, A. Verticchio Vercellin2, N. Moore1, T. J. Knight1, B. Kaskan1, C. Jonescu-Cuypers1, G. Eckert3, B. A. Siesky1. 1 Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy;3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2980 — A0329 Longitudinal changes in macular thickness correlate with changes in retrobulbar vascular resistance in open-angle glaucoma patients with diabetes mellitus. Thai Do1, A. Harris1, A. Verticchio Vercellin2, N. Moore1, C. Ridenour1, A. Belamkar1, G. Eckert3, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, iRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2986 — A0335 Retrobulbar blood flow velocities predict functional progression in openangle glaucoma patients differently according to age. Alexander Snyder1, A. Harris1, N. Moore1, A. Verticchio Vercellin2, C. Ridenour1, G. Eckert3, S. Wentz1, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2981 — A0330 Longitudinal changes in retrobulbar blood flow more strongly correlate with changes in optic nerve head structure in open-angle glaucoma patients with diabetes mellitus. Tyler J. Knight1, A. Harris1, B. A. Siesky1, N. Moore1, C. Ridenour1, B. Kaskan1, G. Eckert3, A. Verticchio Vercellin2. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2987 — A0336 Large choroidal vessel thickness drives change in choroidal thickness with IOP following Trabeculectomy. Xuemin Zhang1, E. Cole2, A. Pillar1, M. Adhi2, N. K. Waheed2, O. Saeedi1.1Ophthalmology, University of Maryland School of Medicine, Burtonsville, MD; 2 Ophthalmology, Tufts Medical Center, Boston, MA 2982 — A0331 Retinal blood flow more strongly correlates with systemic blood pressure and ocular perfusion pressure in open-angle glaucoma patients with diabetes mellitus. Katherine Hutchins1, A. Harris1, N. Moore1, A. Verticchio Vercellin2, C. Ridenour1, B. Kaskan1, G. Eckert3, B. A. Siesky1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2 University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, IN; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2983 — A0332 Racial differences in correlations between optic nerve head morphology and ocular blood flow in healthy eyes. Koosha Ramezani, A. Harris, B. A. Siesky, C. Olinde, D. WuDunn, B. Kaskan, J. Eikenberry, L. A. Tobe, L. Racette. Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, IN *CR 2984 — A0333 Retinal arterial vessel crosssectional area more strongly correlates with structural parameters in open-angle glaucoma patients of African descent. Brent A. Siesky1, A. Harris1, A. Verticchio Vercellin2, A. Huang1, T. J. Knight1, Y. Catoira-Boyle1, G. Eckert3, D. WuDunn1, N. Moore1. 1Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy; 3Biostatistics, Indiana University School of Medicine, Indianapolis, IN *CR 2988 — A0337 Relationship between oxygen saturation of the retinal vessels and visual field defect in glaucoma patients: comparison with each hemifield. Kazuyuki Hirooka, T. Shimazaki, Y. Nakano, E. Nitta, K. Ukegawa, S. Sato, A. Tsujikawa. Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan 2989 — A0338 Retrobulbar blood flow predicts functional and structural progression in openangle glaucoma patients with greater body mass indices. Leslie A. Tobe1, A. Harris1, B. A. Siesky1, N. Moore1, A. Huang1, C. Ridenour1, Y. Catoira-Boyle1, G. Eckert2, A. Verticchio Vercellin3. 1 Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2Biostatistics, Indiana University School of Medicine, Indianapolis, IN;3University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy *CR 2990 — A0339 Ocular perfusion pressure as a surrogate for ocular perfusion: mathematical and statistical methods to interpret clinical data. Giovanna Guidoboni1, A. Harris2, A. Guglielmi3, S. Cassani1, B. A. Siesky2. 1Mathematical Sciences, Indiana University Purdue University Indianapolis, Indianapolis, IN; 2Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 3 Mathematics, Politecnico di Milano, Milano, Italy*CR 2991 — A0340 Computer-aided ophthalmic artery waveform analysis in healthy individuals and glaucoma patients. Lucia Carichino1, G. Guidoboni1, 2, A. Verticchio Vercellin4, G. Milano4, C. Cutolo3, C. Tinelli5, A. De Silvestri5, S. Lapin6, 7, B. A. Siesky2, A. Harris2. 1Mathematical Sciences, Indiana University Purdue University Indianapolis, Indianapolis, IN; 2Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 3 University Eye Clinic, DiNOGMI, University of Genoa, Genoa, Italy; 4University Eye Clinic, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy; 5Clinical Epidemiology and Biometric Unit, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy; 6Washington State University, Pullman, WA; 7Kazan Federal University, Kazan, Russian Federation *CR 2992 — A0341 The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Glaucoma. Naoki Kiyota, Y. Shiga, M. Sato, S. Maekwa, K. Omodaka, K. Maruyama, H. Takahashi, H. Kunikata, T. Nakazawa. Ophthalmology, Tohoku university school of medicine, Sendai-shi, Japan 2993 — A0342 Ocular neurovascular changes during head-down posture predict future retinal nerve fiber layer loss in glaucoma suspects. Giacinto Triolo1, 2, W. J. Feuer1, P. F. Monsalve1, L. E. Vazquez1, J. J. McSoley1, L. Ventura1, V. Porciatti1. 1Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Ophthalmology, University Scientific Institute San Raffaele, Milan, Italy 2994 — A0343 Choroidal Volume Change with Acute Intraocular Pressure Elevation in Primary Angle-Closure Suspects. Ya Xing Wang1, R. Jiang1, H. Shi2, L. Xu1, J. B. Jonas3. 1Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing, China; 2College of Biomedical Engineering, Capital Medical University, Beijin, China; 3Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Manheim, Germany 2995 — A0344 Evaluation of retinal blood flow before and after topical tafluprost treatment in glaucoma patients using adaptive optics scanning laser ophthalmoscopy. Yuto Iida, T. Akagi, H. Nakanishi, H. Ikeda, S. Morooka, K. Suda, T. Hasegawa, H. Yamada, M. Yoshikawa, A. Uji, N. Yoshimura. Department of Ophthalmology and Visual Sciences, Kyoto University, Kyoto City, Japan *CR 2996 — A0345 Assessment of the ophthalmic artery and the superior ophtalmic vein blood flow in glaucoma patients with Phase contrast MRI, preliminary results. Veronique Promelle2, 1, S. Milazzo2, 1, G. Pagé3, 1, J. Daouk3, 1, R. Bouzerar3, 1, O. Balédent3, 1. 1Université de Picardie Jules Verne, Amiens, France; 2Ophthalmology, University Hospital of Amiens, Amiens, France; 3 Medical Image Processing Unit, University Hospital of Amiens, Amiens, France The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 214 Tuesday – Posters – 2997 – 3019 2997 — A0346 The effect of low cerebrospinal fluid pressure on optic disc and macula perfusion in monkey model using optical coherence tomography angiography. Ningli Wang. Dept of Ophthalmology, Beijing Tongren Eye Center, Beijing, China 2998 — A0347 Vasodilating effect of Ripasudil Hydrochloride Hydrate on isolated rabbit posterior ciliary arteries. Takako Sugimoto, H. Chuman, N. Nao-i. Opthalmology, Miyazaki University, Miyazaki, Japan 2999 — A0348 The effect of chronic hypertension on retinal autoregulation in rats. Anna K. van Koeverden, Z. He, C. T. Nguyen, A. J. Vingrys, B. V. Bui. Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia 3001 — A0350 The effect of ocular perfusion pressure lowering on vessel diameter and astrocyte calcium in the rat retina. Grant Cull1, L. Wang1, H. Li3, B. V. Bui2. 1Ophthalmology, Devers Eye Institute, Portland, OR; 2Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, VIC, Australia; 3 Department of Ophthalmology, Shanghai Tenth People’s Hospital, Shanghai, China 3002 — A0351 Localization of AT1 and MAS receptors on porcine retinal arteries. Arnar Ossur Hardarson1, S. Ingthorsson2, T. Eysteinsson1. 1 Physiology, University of Iceland, Reykjavik, Iceland; 2Stem Cell Research Unit, University of Iceland, Reykjavik, Iceland Exhibit/Poster Hall A0352-A0394 Tuesday, May 03, 2016 8:30 AM-10:15 AM Glaucoma / Retina 314 Glaucoma Clinical studies / Pharmacology Moderators: Kuldev Singh and Shan C. Lin 3003 — A0352 Review of anterior segment neovascularization cases treated with intravitreal vascular endothelial growth factor inhibitors. Maria Velazquez-Lamela, N. Bhagat, M. A. Zarbin, A. S. Khouri. Ophthalmology, Rutgers-NJMS, New York, NY 3005 — A0354 Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients. J Mario Wolosin1, A. Want1, S. Gillespie1, Z. Wang1, R. Ritch2, A. M. Bernstein1.1Ophthalmology, Icahn School of Medicine, New York, NY; 2Visual Sciences, NYEER, New York, NY 3006 — A0355 Additive ocular hypotensive effects of Bimatoprost Sustained-Release intracameral implant on potent topical therapy in monkeys. Susan S. Lee, A. S. Almazan, H. Li, A. N. Ghebremeskel, P. M. Hughes, M. R. Robinson, J. A. Burke. Allergan, Inc., Irvine, CA *CR 3007 — A0356 Assessing Concordance of Aqueous Humor Flow and IOP Changes After Timolol. Sayoko E. Moroi1, M. G. Trese1, D. Reed1, M. Renner1, V. Gulati2, A. Kazemi3, J. McLaren3, D. Musch1, C. Toris4, A. J. Sit3. 1Ophthalmology, Univ of Michigan-Kellogg Eye Ctr, Ann Arbor, MI; 2Ophthalmology, UNMC, Omaha, NE; 3 Ophthalmology, Mayo Clinic, Rochester, MN; 4 Ophthalmology, Case Western Reserve University, Cleveland, OH *CR, f 3008 — A0357 Elevated IOP primarily induces responses in the vascular cells in animal models of glaucoma in vivo and in vitro. Verena Prokosch2, K. Brockhaus1, F. Anders2, M. Meyer zu Horste1, N. Pfeiffer2, S. Thanos1. 1Institute for Experimental Ophthalmology, University Hospital Muenster, Muenster, Germany; 2Medical University Center Mainz, Mainz, Germany 3009 — A0358 Priming of the NLRP3 inflammasome in optic nerve head astrocytes by mechanical strain and stimulation of the P2X7 receptor. Claire H. Mitchell, F. Albalawi, J. Lim, W. Lu. University of Pennsylvania, Philadelphia, PA 3010 — A0359 The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes. Pei Ge1, I. Navarro2, M. Kessler1, S. Bernier1, N. Perl1, R. Sarno1, J. Masferrer1, G. Hannig1, W. D. Stamer2. 1 Ironwood Pharmaceuticals, Cambridge, MA; 2 Ophthalmology, Duke University, Durham, NC *CR 3011 — A0360 Altered interactions of concomitant administrations of ROCK inhibitor and parasympathetic agonist in mouse IOP and outflow dynamics. Reiko Yamagishi1, M. Honjo1, Y. Aoyama1, T. Uchida1, 2, M. Aihara1. 1Ophthalmology, University of Tokyo, Bunkyo-ku, Japan; 2Senju Pharmaceutical Co., Ltd., Kobe, Japan *CR 3012 — A0361 The effect of TRPV4 in Primary Cilia Signaling. Na Luo1, X. Hu1, M. Qi1, Y. Sun1, 2. 1 Ophthalmology, Medicine school of Indiana University, Indianapolis, IN; 2Glick Eye Institute, Indianapolis, IN 3013 — A0362 Mechanical strain modulates TRPV4-dependent cytoskeletal reorganization in the trabecular meshwork. David Krizaj1, 2, M. Lakk1, T. T. Phuong1. 1Ophthalmology & Visual Sciences, Univ of Utah School of Med, Salt Lake City, UT; 2Neurobiology & Anatomy, University of Utah, Salt Lake City, UT *CR 3014 — A0363 Trabecular meshwork Wnt signaling pathway is altered by non-Pigmented ciliary epithelium derived exosomes. Natalie Lerner. Clinical Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel 3015 — A0364 The multiple hit theory of primary open angle glaucoma. Michael Giovingo1, K. Green2, K. Carey2, I. Bielskus2, M. Patel2, L. R. Pasquale3, T. Patrianakos1, J. R. Samples4, E. Martin1, P. A. Knepper2, 5. 1Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; 2 Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 3Ophthalmology, Massachusetts Eye and Ear, Chicago, IL; 4 Vista University, Parker, CO; 5Ophthalmology, Northwestern University, Chicago, IL *CR 3016 — A0365 Source of Optic Nerve Metabolic Vulnerability in DBA/2J Model of Glaucoma. Denise M. Inman1, P. G. Palmer2. 1 Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH;2Bio-Med Science Academy, Rootstown, OH 3017 — A0366 Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure. Dan Heller1, A. Marcovich4, A. Katz2, D. M. Tal2, M. Habeck2, E. Ben Zeev3, B. Rabah4, Y. Barkana1, S. J. Karlish2. 1Department of ophthalmology, Assaf Harofe medical center, Rehovot, Israel; 2 Deptartment of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; 3Israel National Centre for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel; 4 Department of ophthalmology, Kaplan medical center, Rehovot, Israel *CR 3018 — A0367 Ocular hypotensive properties of water soluble prodrugs of the ATP sensitive potassium channel opener cromakalim. Uttio Roy Chowdhury1, K. B. Viker1, P. I. Dosa2, M. P. Fautsch1.1Ophthalmology, Mayo Clinic, Rochester, MN; 2Medicinal Chemistry, Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN 3019 — A0368 Long-term latanoprost release from a subconjunctival drug delivery system. Franziska Kopp1, T. Eickner1, K. Falke2, R. Guthoff1, 2. 1Institute for Biomedical Engineering, University Medical Center Rostock, Rostock, Germany; 2Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 215 Tuesday Posters 8:30 am – 10:15 am 3000 — A0349 The longitudinal changes of optic nerve head blood flow of the normal rats using laser speckle flowgraphy. yasushi wada. Ophthalmology, Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan., Kanazawa city, Japan; Ophthalmology, Ophthalmology, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan., Kanazawa, Japan., Japan 3004 — A0353 Effects of Atorvastatin on Aqueous Humor Outflow and Porcine Trabecular Meshwork Cells. Lin Cong, J. Zhang, S. Fu, Y. Zhang, Y. Zhang. Huashan Hospital of Fudan University, Shanghai, China 3020 – 3034 – Tuesday – Posters 3020 — A0369 Efficacy and safety of switching prostaglandin analogue-monotherapy to tafluprost/timolol fixed-combination. Kazuyoshi Kitamura, T. Chiba, F. Mabuchi, K. Kashiwagi. Biomedical Enginnering, University of Yamanashi, Chuo, Japan *CR, f 3021 — A0370 Design and Development of ENV515 Intraocular Applicator for Intracameral Injections of ENV515 Glaucoma Extended Release (XR) Therapy. Tomas Navratil1, J. Delgado2, A. Garcia1, G. Willard2, A. Corson2, R. S. Verhoeven1, L. Trevino1, R. Schiffman1. 1Envisia Therapeutics, Research Triangle Park, NC; 2EGGilero, Durham, NC *CR, f Tuesday Posters 8:30 am – 10:15 am 3022 — A0371 Intracameral Administration of a Sustained Release Bimatoprost Implant Efficiently Delivers Bimatoprost to Target Tissue Reducing Risk of Topical Prostaglandin AnalogAssociated Adverse Events. Jennifer Seal1, S. Perera2, M. Coote3, M. R. Robinson1, P. M. Hughes1, A. N. Ghebremeskel1, J. A. Burke1, M. Attar1. 1 Allergan plc, Irvine, CA; 2Singapore National Eye Centre, Singapore, Singapore;3Melbourne Eye Specialists, Melbourne, VIC, Australia *CR, f 3023 — A0372 Results of Phase IIB SYLTAG clinical trial with bamosiran in patients with glaucoma. Victoria Gonzalez1, J. MorenoMontanes2, 9, M. Oll3, K. N. Sall4, K. Palumaa5, H. Dubiner6, K. Turman7, F. Muñoz-Negrete8, 9, V. Ruz1, A. Jimenez1. 1Ophthalmology, Sylentis, Tres Cantos Madrid, Spain; 2Ophthalmology, Clinical Universidad Navarra, Navarra, Spain; 3Tartu olikooli kliinikum, Tartu, Estonia; 4Sall Research medical center, Artesia, CA; 5East-Tallinn Central Hospital Eye Clinic, Tallinn, Estonia; 6Clayton eye center, Morrow, GA; 7Eye Clinic Dr. Krista Turman, Talliin, Estonia; 8Hospital Ramón y Cajal, Madrid, Spain; 9Oftared, Pamplona, Spain *CR, f 3024 — A0373 A Phase 1 Pharmacokinetic Study to Assess the Relative Systemic Bimatoprost Exposure Following Placement of a Novel Bimatoprost Ocular Insert in Healthy Adults. Gary Walker1, J. E. Patrick4, K. N. Sall2, W. G. Kramer3, R. L. Phelps5, S. Soni1, M. Gee-Shihabi6, C. P. Semba1. 1Clinical Research, ForSight VISION 5, Menlo Park, CA; 2Sall Eye Research Medical Center, Artesia, CA; 3Kramer Consulting, LLC, North Potomac, MD; 4Patrick’s Pharmaceutical Consulting, LLC, Aiken, SC; 5 PharmAdvance Consulting, Inc, Sequim, WA; 6 Intertek Pharmaceutical Services, San Diego, CA *CR, f 3026 — A0375 Patient satisfaction related to tolerance when treated with preservative-free latanoprost; results from the PASSY survey in six European countries. Hans G. Lemij1, I. Stalmans2, C. Erb3, F. Munoz4. 1Ophthalmology, Rotterdam Eye Hosp (Oogziekenhuis Rotterdam), Rotterdam, Netherlands; 2University Hospitals Leuven, Leuven, Belgium; 3Augenklinik am Wittenbergplatz, Berlin, Germany; 4Ramon y Cajal Hospital, Madrid, Spain *CR 3027 — A0376 Efficacy of 4% Hydroquinone in Japanese Glaucoma Patients with Topical Prostaglandin Analogue-induced Eyelid Pigmentation: A Randomized, EvaluatorsBlinded, Left-Right Comparison Study. Koichi Ono1, R. Ueki2, T. Kimura3, K. Akimoto4, R. Umeya1, K. Akashi2, S. Ohgiya2, M. Kawashima5. 1 Department of Ophthalmology, Juntendo Tokyo-Koto Geriatric Medical Center, Koto-ku, Japan;2Department of Dermatology, Juntendo Tokyo-Koto Geriatric Medical Center, KotoKu, Japan; 3Department of Ophthalmology, Ueno Eye Clinic, Taito-ku, Japan; 4Department of Dermatology, Skin Care Ueno Clinic, Taitoku, Japan; 5Department of Dermatology, Tokyo Women’s Medical University, Shinjuku-ku, Japan f 3028 — A0377 The In Vivo Effect of Preservative Benzalkonium Chloride on Corneal Immune Cells and Clinical Signs in Glaucoma Therapy. Yureeda Qazi1, A. Cruzat3, 1, B. M. Cavalcanti1, C. Colon1, D. Witkin1, T. C. Chen4, P. Hamrah2, 1. 1Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Boston, MA; 2 New England Eye Center, Tufts University, Boston, MA; 3Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA; 4Glaucoma, Massachusetts Eye and Ear Infirmary, Boston, MA *CR, f 3029 — A0378 A phase I First-In Human single ascending dose study of ISTH0036, a potent and selective antisense oligonucleotide targeting transforming growth factor beta 2 (TGF-β2) for the treatment of primary openangle glaucoma. Bogomil Voykov1, K. Lorenz2, C. Schuart3, P. Richter1, B. Wilhelm4, L. Choritz3, V. Prokosch-Willing2, P. Fettes5, E. Leo5, N. Pfeiffer2. 1 Centre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany; 2Ophthalmology, University Medical Center Mainz, Mainz, Germany; 3 Ophthalmology, Otto-von-Guericke-University, Magdeburg, Germany; 4STZ Eyetrial at the Centre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany; 5Isarna Therapeutics GmbH, Munich, Germany *CR, f 3025 — A0374 Completed 28-Day and Ongoing 12-Month Safety and Efficacy Evaluation of ENV515 (travoprost) Intracameral Implant in Phase 2 Study. Thomas R. Walters1, T. Navratil2, S. Pittman2, V. Conley2, L. Trevino2, B. E. Silverstein3, M. Depenbusch4, S. L. Mansberger5, R. Schiffman2. 1 Texan Eye/Keystone Research, Austin, TX; 2 Envisia Therapeutics, Research Triangle Park, NC; 3 Shasta Eye Medical Group, Redding, CA; 4Arizona Eye Center, Phoenix, AZ; 5Devers Eye Institute, Portland, OR *CR, f 3030 — A0379 Long-term Efficacy and Safety of Latanoprostene Bunod 0.024% for Intraocular Pressure Lowering in Patients with Open-Angle Glaucoma or Ocular Hypertension: APOLLO and LUNAR Studies. Jason L. Vittitow1, J. M. Liebmann2, P. L. Kaufman3, F. A. Medeiros4, K. R. Martin5, R. N. Weinreb6. 1Clinical Affairs, Bausch + Lomb, Bridgewater, NJ; 2Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY; 3Department of Ophthalmology & Visual Sciences, Univ of Wisconsin Sch of Med & Public Hlth, Madison, WI; 4Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, CA; 5Eye Department, Addenbrooke’s Hospital and Cambridge NIHR Biomedical Research Centre, Cambridge, United Kingdom; 6Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, CA *CR, f 3031 — A0380 IOP-lowering effects of NCX 667 in combination with travoprost in ocular normotensive and transient hypertensive rabbits. Elena Bastia1, E. Masini2, M. Durante2, M. Bergamini3, E. Ongini1, F. Impagnatiello1. 1 Nicox Research Institute, Bresso (MI), Italy; 2 NEUROFARBA, Section of Pharmacology and Toxicology, Firenze, Italy; 3Nicox Ophthalmics Inc., Fort Worth, TX *CR 3032 — A0381 Intraocular pressurelowering efficacy and safety of 0.4% ripasudil. Hideki Mochizuki2, 1, K. Noma2, Y. Kiuchi1. 1 Ophthalmology, Hiroshima University, Hiroshima, Japan; 2Private practice, Hiroshima, Japan 3033 — A0382 Specific clinical features of intraocular pressure-lowering effect in ripasudil (K-115): insights from 52-week phase 3 study. Hidenobu Tanihara1, T. Inoue1, T. Yamamoto5, Y. Kuwayama4, H. Abe7, A. Fukushima2, H. Suganami3, M. Araie6. 1Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; 2Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi, Japan; 3Kowa Company, Ltd, Nagoya, Japan; 4 Fukushima Eye Clinic, Osaka, Japan; 5Department of Ophthalmology and Visual Science, Gifu University Graduate School of Medicine, Gifu, Japan; 6Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan; 7Niigata University of Health and Welfare, Niigata, Japan *CR, f 3034 — A0383 Intraocular pressure-lowering and ocular exposure of NCX 1653, a novel nitric oxide-donating travoprost in models of ocular hypertension and glaucoma. Francesco Impagnatiello1, L. Storoni1, S. Brambilla1, E. Masini2, C. Lanzi2, C. B. Toris3, M. Bergamini4, E. Ongini1, E. Bastia1. 1Nicox Research Institute, Bresso (MI), Italy; 2NEUROFARBA, Section of Pharmacology and Toxicology, Firenze, Italy;3University of Nebraska Medical Center, Omaha, NE; 4Nicox Ophthalmics Inc., Fort Worth, TX *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 216 Tuesday – Posters – 3035 – 3057 3035 — A0384 Efficacy of Latanoprostene Bunod 0.024% vs. Timolol Maleate 0.5% for Intraocular Pressure Lowering in Patients with Open-Angle Glaucoma or Ocular Hypertension: the LUNAR Study.James H. Peace1, F. A. Medeiros2, K. R. Martin3, J. L. Vittitow4, R. N. Weinreb5. 1United Medical Research Institute, Inglewood, CA; 2Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, CA; 3Eye Department, Addenbrooke’s Hospital and Cambridge NIHR Biomedical Research Centre, Cambridge, United Kingdom; 4 Clinical Affairs, Bausch + Lomb, Bridgewater, NJ; 5 Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, CA *CR, f 3037 — A0386 Long-term Safety and Intraocular Pressure Lowering Efficacy of Latanoprostene Bunod 0.024% in Japanese Subjects with Open-Angle Glaucoma or Ocular Hypertension: the JUPITER Study. Kazuhide Kawase1, J. L. Vittitow2, T. Yamamoto1, M. Araie3. 1 Gifu University Hospital, Gifu, Japan; 2Clinical Affairs, Bausch + Lomb, Bridgewater, NJ; 3Kanto Central Hospital of The Mutual Aid Association of Public School Teachers, Tokyo, Japan *CR, f 3038 — A0387 Evidence for GPR18 role in diurnal regulation of intraocular pressure. Alex Straiker, O. oehler, L. Daily, E. leishman, H. Bradshaw. Indiana University, Bloomington, IN 3039 — A0388 Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis - 1 year follow up. Joao J. Nassaralla1, J. J. Nassaralla3, A. A. Nassaralla2. 1Ophthalmology, Instituto de Olhos de Goiania and UnB, Goiania, Brazil; 2Ophthalmology, FMSLM, Campinas, Brazil; 3Ophthalmolgy, UFG, Goiania, Brazil f 3040 — A0389 Stability study of Bamosiran (a siRNA compound) in ophthalmic solution in different containers. Veronica Ruz, V. Gonzalez, A. Jimenez, L. Company, Y. Ruiz, C. Astrain. Ophthalmology, Sylentis, Madrid, Spain *CR 3049 — B0004 Epidemiology Of Ocular Injuries In Major Trauma-The Bronx Experience. Lediana Goduni1, D. Poulsen1, 3, J. Mbekeani1, 2. 1Medicine, Albert Einstein College of Medicine, Bronx, NY; 2Surgery, North Bronx Health Network, Bronx, NY; 3Ophthalmology and Visual Sciences, Montefiore Medical Center, Bronx, NY 3043 — A0392 A Multicenter Study Assessing Inter-Examiner Agreement of Gonioscopic Shaffer Grading in Patients with Open-Angle Glaucoma and/or Ocular Hypertension. Reihab Ahmed, B. Khan, M. Chen, M. R. Robinson, S. S. Lee. Allergan plc, Irvine, CA *CR, f 3050 — B0005 Characterisitics Of Ocular Trauma In Elderly Patients Of The Bronx. Isaac Chocron1, 3, D. Poulsen1, 3, L. Goduni1, J. Mbekeani1, 2. 1Albert Einstein College of Medicine, Bronx, NY; 2Surgery, North Bronx Health Network, Bronx, NY; 3Opthalmology & Visual Sciences, Montefiore Medical Center, Bronx, NY 3044 — A0393 Does Knowledge of the Risk Factors of Glaucoma Impact Adherence in patients of African descent? Kadé Diallo4, S. Bigatti2, B. Sutton3, J. Torbit3, L. Racette1. 1 Ophthalmology-Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN; 2 Indiana University Fairbanks School of Public Health, Indianapolis, IN; 3Indianapolis Eye Care Center, Indiana University School of Optometry, Indianapolis, IN;4Ophthalmology, Glick Eye Insttitute, Indiana University School of Medicine, Indianapolis, IN 3045 — A0394 Age-related changes in aqueous humor dynamics in healthy Chinese adults. tao guo. ophthalmology, Shanghai ninth people’s hospital,Shanghai JiaoTong University School of Medicine, ShangHai, China; ophthalmology, Shanghai Tenth people’s hospital, ShangHai, China Exhibit/Poster Hall B0001-B0013 Tuesday, May 03, 2016 8:30 AM-10:15 AM Clinical/Epidemiologic Research 315 Trauma: Effects and Outcomes Moderator: Roomasa Channa 3046 — B0001 Orbital fracture management and race. Kalla A. Gervasio, A. Y. Wu. Icahn School of Medicine at Mount Sinai, New York, NY 3047 — B0002 A Review of Orbital Fractures at a Level 1 Trauma Center - Do all visually asymptomatic patients require emergent ophthalmological evaluation? Mehul Patel. Ophthalmology, Howard University, Arlington, VA 3048 — B0003 Aetiology and injury patterns of orbital fractures across age groups in a tertiary centre in Singapore: A retrospective study of 333 patients. Kailing Yong1, 2, I. loh3, S. shen1, 2. 1Singapore National Eye Centre, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore, Singapore; 3ENT, Changi General Hospital, Singapore, Singapore 3041 — A0390 Changes in ocular hypotensive effect of Rho-associated protein kinase inhibitor, Ripasudil, with pilocarpine and timolol in rabbit eye. Yu Mizuno, Y. Kiuchi. Hiroshima University, Hiroshima, Japan 3051 — B0006 Epidemiology of Outpatient Ocular Trauma - The Bronx Experience. David Poulsen1, 2, L. Goduni1, J. Mbekeani1, 3. 1 Ophthalmology, Albert Einstein College of Medicine, Bronx, NY;2Ophthalmology, Montefiore Medical Center, Bronx, NY; 3Surgery, North Bronx Health Network, Bronx, NY 3052 — B0007 Endophthalmitis After Open Globe Repair. Xintong Li, M. A. Zarbin, P. D. Langer, N. Bhagat. Ophthalmology, Rutgers New Jersey Medical School, Newark, NJ 3053 — B0008 The Inland Empire Eye Emergency Epidemiology Study. Kimberly M. Chan, C. G. Maddux, M. Rauser. Ophthalmology, Loma Linda University, Loma Linda, CA 3054 — B0009 Outcomes of Post-traumatic Glaucoma in Assault Injuries. Kelly Lee, C. Seery, A. Yadgarov, A. S. Khouri. Institute of Ophthalmology & Visual Sciences, Rutgers New Jersey Medical School, Newark, NJ 3055 — B0010 Anterior chamber collapse syndrome is caused by presumed early life trauma in canines and felines. Gillian C. Shaw, R. R. Dubielzig, L. B. Teixeira. Comparative Ocular Pathology Laboratory, Department of Pathobiological Sciences, University of Wisconsin, Madison, WI 3056 — B0011 Severe acute ocular chemical injuries - retrospective clinical audit of 38 consecutive new admissions in a tertiary hospital in the UK. Borja Salvador-Culla1, J. Hogg2, A. Okonkwo2, J. Mulroy1, G. S. Figueiredo2, 3, F. C. Figueiredo2, 3. 1Ophthalmology, Royal Victoria Infirmary, Newcastle Upon Tyne, Boston, MA; 2 Ophthalmology, Royal Victoria Infirmary, Newcastle University, Newcastle Upon Tyne, United Kingdom; 3Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom 3057 — B0012 Knowledge, Attitudes, and Practices of Eye Safety Among Skilled Manual Workers. Rohini Rao, M. Gardiner, M. Hymowitz. Ophthalmology, Massachusetts Eye And Ear Infirmary, Boston, MA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 217 Tuesday Posters 8:30 am – 10:15 am 3036 — A0385 Integrated Efficacy of Latanoprostene Bunod 0.024% vs. Timolol Maleate 0.5% for Intraocular Pressure Lowering in Patients with Open-Angle Glaucoma or Ocular Hypertension: APOLLO and LUNAR Studies. Paul L. Kaufman1, J. M. Liebmann2, J. L. Vittitow3, R. N. Weinreb4. 1Department of Ophthalmology & Visual Sciences, Univ of Wisconsin Sch of Med & Public Hlth, Madison, WI;2Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY; 3Clinical Affairs, Bausch + Lomb, Bridgewater, NJ; 4Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, San Diego, La Jolla, CA *CR, f 3042 — A0391 Effect of Brimonidine 0.15% versus Pilocarpine 2% on Angle configuration and Miosis in Eyes with Angle Closure. David Chen1, 2, B. Mani1, 2, S. Perera1, 2, R. Husain1, 2, T. Aung1, 2.1Singapore Eye Research Institute, Singapore, Singapore; 2Singapore National Eye Centre, Singapore, Singapore *CR, f 3058 – 3077 – Tuesday – Posters 3058 — B0013 Review of Malpractice Litigation in Ocular Trauma over Eight Decades. Sherveen S. Salek1, S. B. Engelhard2, C. Shah2, A. Sim2, A. Reddy1. 1Ophthalmology, Johns Hopkins Hospital - Wilmer Eye Institute, Baltimore, MD; 2 University of Virginia, Charlottesville, VA Exhibit/Poster Hall B0046-B0064 Tuesday, May 03, 2016 8:30 AM-10:15 AM Lens 316 Lens development and fiber cell biology Moderator: Salil A. Lachke Tuesday Posters 8:30 am – 10:15 am 3059 — B0046 Lentoid bodies derived from human induced pluripotent stem cells model the human lens genesis in vitro. Qiuli FU1, Z. Qin1, J. Ji2, K. Yao1, 2. 1the 2nd Affiliated Hospital of Zhejiang University, Hangzhou, China; 2Medical School of Zhejiang University, Hangzhou, China 3060 — B0047 A 3D Lens Cell Culture Platform to Mimic the Developing Lens. Eddie Wang, D. Wang, A. Geng, A. Maniar, X. Gong. Optometry, University of California, Berkeley, Berkeley, CA 3061 — B0048 Identification of abnormally expressed miRNAs in Tdrd7 null mouse lens. Deepti Anand1, C. E. Barnum1, S. A. Lachke1, 2. 1 Department of Biological Sciences, University of Delaware, Newark, DE; 2Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 3062 — B0049 Requirements for cellular folate during lens development. Maria Muccioli, T. F. Plageman. College of Optometry, The Ohio State University, Logan, OH 3063 — B0050 Identification of a new RNA binding protein Rbm24 linked to anophthalmia, microphthalmia and lens defects. Soma Dash1, S. A. Lachke1, 2. 1Department of Biological Sciences, University of Delaware, Newark, DE; 2Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 3064 — B0051 On cluster sizes during lens growth in the mouse. Hrvoje Sikic1, 2, S. Bassnett1. 1 Ophthalmology, Washington University in St.Louis, St. Louis, MO; 2Mathematics, University of Zagreb, Zagreb, Croatia 3065 — B0052 Postnatal human lens growth: finding the relationship between dimensions and weight. Ashik Mohamed1, 2, R. C. Augusteyn2, 3, H. A. Durkee4, V. S. Sangwan1, 3, J. A. Parel3, 4. 1 Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India; 2School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW, Australia; 3Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, NSW, Australia; 4Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 3066 — B0053 Automatic quantification of fluorescence signal in rat lens epithelium. Nooshin Talebizadeh1, Z. Yu1, N. Z. Hagström2, C. Wählby2, P. G. Soderberg1. 1Neuroscience department, Uppsala University, Uppsala, Sweden; 2 Department of Information Technology, Uppsala University, Uppsala, Sweden 3067 — B0054 The role of fibrillin-1 in ciliary zonule synthesis and lens growth. Wendell Jones, S. Bassnett. Biomedical Sciences, Washington University, St.Louis, MO 3068 — B0055 RanGAP1, the most Prominently SUMOylated Lens Proteins Regulates Cell Cycle in Lens. David W. Li1, 2, W. Ji1, X. Hu1, L. Gong2, Z. Huang1, L. Wang2, 1, Y. Liu2, Q. Nguyen1. 1University of Nebraska Medical Center, Omaha, NE; 2Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 3069 — B0056 Imaging the glutathione redox potential in the intact lens. Miduturu Srinivas1, J. Gao1, R. Mathias2, N. SLAVI1. 1Biological and Vision Sciences, SUNY College of Optometry, New York, NY;2Physiology, SUNY Stony Brook, Stony Brook, NY 3070 — B0057 Cell-Cell Adhesion Mediated by the Second Extracellular Domain of Connexin 50 Promotes Lens Epithelial-Fiber Cell Differentiation. Jean X. Jiang, Z. Hu, W. Shi, S. Gu. Biochemistry, University of Texas Health Science Center, San Antonio, TX 3071 — B0058 Alpha N-catenin, a Neuronal Subtype Catenin Exhibits Fiber Cell Specific Distribution; Regulation of the Alpha N-catenin: N-Cadherin Interaction by Periaxin in Mouse Lens. Rupalatha Maddala1, J. Qiu1, R. Pratheepa Kumari1, V. Rao2. 1Ophthalmology, Duke University Medical Center, Durham, NC; 2Ophthalmology & Pharmacology, Duke University Medical Center, Durham, NC 3073 — B0060 Tropomodulin 1 regulation of actin is required for the formation of large paddle protrusions between mature lens fiber cells. Velia M. Fowler1, C. Cheng1, R. B. Nowak1, S. K. Biswas2, W. Lo2, P. G. FitzGerald3. 1Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA; 2Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA; 3 Department of Cell Biology and Human Anatomy, University of California, Davis, CA 3074 — B0061 The interaction of BFSP1 and its proteolytically derived fragments with cell membranes. Roy A. Quinlan1, 5, A. Tapodi2, D. Clemens4, K. Nemeth-Cahalan3, I. Vorontsova3, P. Jakus2, C. Cawood1, M. Jarrin1, J. E. Hall3. 1 School of Biological and Biomedical Sciences, Biophysical Sciences Inst, Durham Univ, Durham, United Kingdom; 2Department of Biochemistry and Medical Chemistry, Pecs, Hungary;3Physiology and Biophysics, UC Irvine, Irvine, CA; 4Life Sciences Addition, UC Berkeley, Berkeley, CA; 5Biophysical Sciences Institute, UNiversity of Durham, Durham, United Kingdom *CR 3075 — B0062 Proteomic and Immunohistochemical Characterization of Lens Fiber Cell Vesicles. Romell Gletten1, Z. Wang1, K. Walker2, A. C. Grey3, P. J. Donaldson3, K. L. Schey1. 1 Biochemistry, Vanderbilt University, Nashville, TN; 2School of Public Health & Psychosocial Studies (HY), Auckland University of Technology, Auckland, New Zealand; 3School of Medical Sciences, The University of Auckland, Auckland, New Zealand 3076 — B0063 Nuclear degradation during formation of the organelle-free zone in nonhuman primate lenses. M J. Costello1, A. Mohamed2, K. Gilliland1, J. Wenke3, K. L. Schey3. 1 Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC; 2LV Prasad Eye Institute, Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India;, Hyderabad, India; 3Biochemistry, Vanderbilt University, Nashville, TN 3077 — B0064 Determination of the best method of ex vivo conservation of the crystalline lens. Amparo Navea1, A. Fandiño1, A. Felipe1, C. Artigas2, J. M. Artigas1. 1FISABIO Oftalmologia (FOM), Valencia, Spain; 2Universidad Cardenal Herrera CEU, Valencia, Spain 3072 — B0059 The Role of BASP-1 and MARCKS in Lens Cytoarchitecture and Function. Rasiah Pratheepa kumari, N. Skiba, V. Rao. Opthalmology, Duke University, Durham, NC The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 218 Tuesday – Posters – 3078 – 3101 Exhibit/Poster Hall B0065-B0088 Tuesday, May 03, 2016 8:30 AM-10:15 AM Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology 317 Amblyopia Moderators: Jingyun Wang and Frank A. Proudlock 3078 — B0065 Binocular iPad game treatment for amblyopia is more successful than patching. Krista R. Kelly1, R. M. Jost1, L. Dao2, C. L. Beauchamp2, J. N. Leffler3, E. E. Birch1, 4. 1 Retina Foundation of the Southwest, Dallas, TX; 2 Pediatric Ophthalmology, PA, The Center for Adult Strabismus, Dallas, TX; 3Children’s Eye Care of North Texas, PA, Dallas, TX; 4Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX f 3080 — B0067 Play Station PortableTM as a therapy for amblyopia in children. Ricardo Torres-Vidal, J. Villaseñor-Solares, A. Ortiz Flores, M. Cedillo-Ley, G. Garcia-Guzman. Asociacion para Evitar la Ceguera en Mexico, Mexico City, Mexico 3081 — B0068 Newly Developed Binocular Treatment of Amblyopia using Head-Mounted Display. Haeng Jin Lee, S. Kim. Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of) 3082 — B0069 Perceptual training significantly improves visual functions in children with amblyopia. Ge Chen1, L. Wang2, F. Hou3, Z. Lu3, C. Huang1. 1Chinese Academy of Sciences, Institute of Psychology, Beijing, China; 2Department of Ophthalmology, Peking University People’s Hospital, Beijing, China; 3Department of Psychology, The Ohio State University, Columbus, OH *CR 3083 — B0070 Baseline factors and visual acuity outcome following binocular amblyopia treatment. Angie De La Cruz1, R. M. Jost1, K. R. Kelly1, E. E. Birch1, 2. 1Pediatric Vision Laboratory, Retina Foundation of the Southwest, Dallas, TX; 2 University of Texas Southwestern Medical Center, Dallas, TX 3084 — B0071 Do reminders on a smartphone increase compliance in amblyopia treatment? Aldo Vagge, K. Gunton, B. Schnall. Wills Eye Hospital, Philadelphia, PA 3086 — B0073 Quality of life and functional vision concerns of children with cataracts and their parents. Yolanda S. Castañeda1, C. S. ChengPatel1, D. A. Leske2, S. M. Wernimont2, S. R. Hatt2, L. Liebermann2, E. E. Birch1, 3, J. M. Holmes2. 1 Retina Foundation of the Southwest, Dallas, TX; 2 Department of Ophthalmology, Mayo Clinic, Rochester, MN; 3UT Southwestern Medical Center, Dallas, TX 3093 — B0080 Amblyopia Treatment Outcomes Assessment Using AAO’s IRIS-7 Measure. Constance E. West1, 2, P. Cobb1, D. L. White3. 1Pediatric Ophthalmology, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH; 2Department of Ophthalmology, University of Cincinnati, Cincinnati, OH; 3James M Anderson Center, Cincinnati Childrens Hospital Medical Center, Cincinnati, OH *CR 3094 — B0081 New Pediatric Vision Screener - Data Analysis and Validation. Boris I. Gramatikov, K. Irsch, Y. Wu, D. L. Guyton. Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, MD *CR 3087 — B0074 Interocular contrast differences and the stability of fixational eye movements. Rajkumar Nallour Raveendran, W. R. Bobier, R. J. Babu, B. Thompson. Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada 3095 — B0082 Dilated Eye Examination among Multi-ethnic Preschool Children. Xuejuan Jiang1, K. Tarczy-Hornoch2, 3, S. A. Cotter4, M. Torres1, R. Varma1. 1USC Eye Institute/Department of Ophthalmology, University of Southern California, Los Angeles, CA; 2Ophthalmology, University of Washington, Seattle, WA; 3Seattle Children’s Hospital, Seattle, WA; 4Southern California College of Optometry, at Marshall B. Ketchum University, Fullterton, CA 3088 — B0075 Effects of amblyopia and strabismus on the performance of a manipulation task involving precision grasping, placement, and action sequencing. Ewa Niechwiej-Szwedo, D. A. Gonzalez. Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada 3096 — B0083 Comparison of the Amblyopia Preferred Practice Patterns of the American Academy of Ophthalmology with the Practices of an Academic Pediatric Ophthalmology Division. Tehilla Steiner, I. Friedman, J. Rosenberg. Ophthalmology, Montefiore Medical Center, Bronx, NY 3089 — B0076 Distance versus near visual acuity in older children and adults with amblyopia. Cindy X. Guo. Optometry and Vision Science, University of Auckland, Auckland, New Zealand f 3097 — B0084 Assessment of the plusoptiX A12 photoscreener to detect amblyogenic risk factors in Nebraska. Thomas Williams1, D. Suh2, 3. 1School of Medicine, Creighton University School of Medicine, Omaha, NE; 2Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE; 3Pediatric Ophthalmology, Children’s Hospital and Medical Center, Omaha, NE 3090 — B0077 Interocular differences in size perception of black-white figure ground asymmetries in anisometropic amblyopia. jing liu, J. Li, Z. Chen, X. Cai, J. Yuan, D. Deng, M. Yu. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center,Sun Yat-Sen University, Guangzhou, China 3091 — B0078 Sparing of coarse stereopsis in stereodeficient children depends on amblyogenic factors. Kimberly Meier1, B. Sum2, L. M. Wilcox3, D. Giaschi2. 1Department of Psychology, University of British Columbia, Vancouver, BC, Canada; 2 Department of Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, BC, Canada; 3Department of Psychology, York University, Toronto, ON, Canada 3092 — B0079 Comparison of two angular eye charts for assessment of visual acuity in amblyopia : Thibaudet and Snellen tests. Claire Iscar1, 2, V. Promelle1, 2, E. Haritchabalet1, S. Milazzo1, 2.1Ophthalmology, Amiens University Hospital, Amiens, France; 2Université de Picardie Jules Verne, Amiens, France 3098 — B0085 Assessment of the OPTEC vision screener in the detection of amblyopia in the pediatric population. Mary Haschke, H. Kinberg, D. W. Suh. U of Nebraska Medical Center, Omaha, NE 3099 — B0086 Referral basis for infantile cataracts. Priyanka Kumar, P. Lenhart, S. R. Lambert. Emory Eye Clinic, Atlanta, GA 3100 — B0087 Visual Profile of Children Passing/Failing a UK School Vision Screening Protocol. Kathryn Saunders, L. O’Donoghue, S. McCullough. Biomedical Sciences Research Institute, Ulster University, Coleraine, United Kingdom 3101 — B0088 Preschool Vision Screening by Parents Using an iPad in Saudi Arabia. Noura A. Aldossary1, 2, A. M. AlSaqr2, E. B. Ciner1, N. Aldohayan3. 1Salus University, Riyadh, Saudi Arabia; 2Optometry Department, King Saud University, Riyadh, Saudi Arabia; 3Ophthalmology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 219 Tuesday Posters 8:30 am – 10:15 am 3079 — B0066 A Randomized Trial of AmblyzTM Liquid Crystal Occlusion Glasses vs Traditional Patching for Treatment of Moderate Unilateral Amblyopia in Children: 6-Month Outcome. Paxton Ott1, D. Neely1, J. Galli1, T. Damarjian1, J. Schliesser1, H. Smith1, K. Haider1, G. Roberts1, D. Sprunger1, D. Plager1, J. Wang2. 1 Vision Sciences, Indiana University School of Medicine, Clayton, IN; 2Pennsylvania College of Optometry, Salus University, Elkins Park, PA f 3085 — B0072 Trends in the incidence and causes of amblyopia and strabismus among teenagers. Yinon Shapira1, M. Mimouni1, Y. Machluf2, Y. Chaiter3, E. Mezer1, 4. 1Ophthalmology, Rambam Healthcare Campus, Haifa, Israel; 2 Weizmann Institute of Sciences, Rechovot, Israel; 3 Israel Defense Forces, Medical Corps, Haifa, Israel; 4Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel 3102 – 3126 – Tuesday – Posters Exhibit/Poster Hall B0107-B0136 Tuesday, May 03, 2016 8:30 AM-10:15 AM Visual Psychophysics/Physiological Optics 318 IOL Optical Properties and Presbyopia Correction Moderators: Fabrice Manns and Geunyoung Yoon Tuesday Posters 8:30 am – 10:15 am 3102 — B0107 Comparative Analysis of Accuracy and Predictability of Intraocular Lens Power Calculation after Refractive Surgery: Conventional Regression Formula versus ASCRS Calculator. Byeong Soo Kang1, J. Oh1, 2, M. Kim1, 2, W. Wee1, 2. 1Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of); 2Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of) 3103 — B0108 Corneal curvature is a key determinant of Haigis and SRKT formulae accuracy of for intentional myopic overcorrection. Andre Messias, R. F. Dalto, F. Miriam, W. Queiroz, R. P. Coelho, J. S. Paula. Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil 3104 — B0109 The tolerance analyses of cylindrical axial misalignment of a TIOL. Huawei Zhao. R&D, Abbott Medical Optics, Inc., Santa Ana, CA *CR 3105 — B0110 An objective method to measure astigmatism tolerance with a small-aperture vs. monofocal intraocular lens. Eugenia K. Thomas1, L. Lin1, S. Vilupuru1, R. Ang2. 1Clinical Research, AcuFocus, Inc., Irvine, CA; 2Asian Eye Institute, Makati City, Philippines *CR 3106 — B0111 Masurement of the pseudoaccommodation curve of intraocular lenses in virtually implanted subjects. Jaume Pujol1, S. O. Luque2. 1Physiology & Membrane Biology, Universitat Politecnica Catalunya, Terrassa, Spain; 2 10Lens S.L.U., Terrassa, Spain *CR 3107 — B0112 Long Term Follow-up of Posterior Chamber Phakic Intraocular Lens for Myopia. Bronson M. LeClair1, 2, H. V. Gimbel1, 2, J. T. Fan1. 1School of Medicine, Loma Linda Univeristy, Loma Linda, CA; 2Gimbel Eye Centre, Calgary, AB, Canada 3108 — B0113 Refractive and safety outcomes of individuals submitted to phakic intraocular lens implantation (ICL) and correlation of ocular measurements. Fabio Kenji K. Matsumoto. Ophthalmology, São Paulo Federal University UNIFESP, São Paulo, Brazil 3109 — B0114 Bilateral Macular Protection Pigment and Lens Density Status in Recently Operated Unilateral Pseudophakic Patients. Amy Schnegg1, 2, W. E. Sponsel1, 2, R. A. Bone3, M. A. Reilly4, S. Leon2, S. Cervantes1. 1William E. Sponsel, M.D., San Antonio, TX; 2Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX; 3Physics, Florida International University, Miami, FL; 4Biomedical Engineering, University of Texas San Antonio, San Antonio, TX *CR 3110 — B0115 Chromatic aberration of intraocular lenses measured in vitro and in vivo. Daniel H. Chang1, H. A. Weeber2, M. Lowery3, P. Piers2. 1Empire Eye and Laser Center, Bakersfield, CA; 2Abbott Medical Optics, Groningen, Netherlands; 3Abbott Medical Optics, Santa Ana, CA *CR 3111 — B0116 Intraocular lens with heterogeneous refractive index correcting field and chromatic aberrations. Enrique-Josua Fernandez, P. Artal. Physics, Universidad de Murcia, Murcia, Spain *CR 3112 — B0117 Implantation of an add-on intraocular lens for patients with age-related macula degeneration. Uwe Oberheide1, 2, O. Kermani2, G. Gerten2. 1Applied optics and electronics, TH Köln Cologne University of Applied Sciences, Cologne, Germany; 2Augenklinik am Neumarkt, Cologne, Germany *CR 3113 — B0118 In vivo evaluation of the tilt in the human crystalline lens or intraocular lens using a full-length optical coherence tomography (OCT)-based biometer. AKENO TAMAOKI1, 2, T. Kojima3, T. Buehren5, R. Hashizume1, Y. Tanaka4, K. Tanaka6, 2, K. Ichikawa4. 1Ophthalmology, Chukyo Hospital, Nagoya, Japan; 2Shinshu University Interdisciplinary Graduate School of Science and Technology, Nagano, Japan;3Ophthalmology, Gifu Red Cross Hospital, Gifu, Japan; 4Chukyo Eye Clinic, Nagoya, Japan; 5Carl Zeiss Meditec, Jena, Germany; 6Faculty of Engineering, Shinshu University, Nagano, Japan *CR 3114 — B0119 Visual quality with combinations of optimized and non-optimized corrective elements. Georgios Zoulinakis1, R. Montés-Micó1, T. Ferrer Blasco1, D. Iskander2. 1Faculty of Physics, University of Valencia, Valencia, Spain; 2Wroclaw University of Technology, Wroclaw, Poland 3115 — B0120 Assessing the optical quality of commercially available intraocular lenses by means of modulation transfer function and straylight. Eleni Papadatou1, G. Labuz2, T. J. Van Den Berg2, J. Esteve-Taboada1, D. Madrid-Costa1, N. Lopez-Gil3, R. Montés-Micó1. 1University of Valencia, Valencia, Spain; 2Rotterdam Ophthalmic Institute, Rotterdam, Netherlands; 3University of Murcia, Murcia, Spain *CR 3116 — B0121 Straylight measurements in intraocular lenses with an optical integration method. Alexandros Pennos, H. S. Ginis, A. Gambin, P. Artal. Laboratorio de Optica, Universidad de Murcia, Murcia, Spain 3117 — B0122 Halo measurement method for intraocular lenses. Marrie Van der Mooren, P. Piers, J. Graver, H. A. Weeber. R&D Implants, AMO Groningen BV, Groningen, Netherlands *CR 3118 — B0123 Parameters affecting both Far Peripheral Vision in phakic eyes and Negative Dysphotopsia with Intraocular Lenses. Michael Simpson. Simpson Optics LLC, Arlington, TX 3119 — B0124 Age-related objective and subjective dysphotopsia. Maana Aujla1, J. Wolffsohn1, 2, A. L. Sheppard1, 2. 1School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; 2Aston Research Centre for Healthy Ageing, Aston University, Birmingham, United Kingdom 3120 — B0125 Impact of Stiles-Crawford peak decentration with small apertures. Pedro Prieto, S. Manzanera, C. Robles, P. Artal. Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain *CR 3121 — B0126 Clinical efficacy of pihhole soft contact lenses for correcting presbyopia. Si Yoon Park, T. Kim, J. Jung, Y. Ji, E. Kim, K. Seo, H. Lee. Department of Ophthalmology, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea (the Republic of) f 3122 — B0127 Clinical Correlates of Multifocal Defocus Curve. Linda Tsai, S. Kasthurirangan, J. Depew, P. Smith, K. Featherstone. Abbott Medical Optics, Santa Ana, CA *CR, f 3123 — B0128 Toric Multifocal Intraocular Lens: 24 months Follow-Up. Valeria Oliva, A. Navas. Cornea, Conde de Valenciana, Mexico, Mexico 3124 — B0129 Crosslink Gain-Control Model to Predict Binocular Defocus Curve for Multifocal Intraocular Lenses. Lin He, S. Jasti. Global Clinical & Regulatory Affairs, Alcon Laboratories Inc. (Novartis), Ft Worth, TX *CR 3125 — B0130 Impact of higher-order aberrations on depth-of-field. Juan F. ZapataDiaz1, I. Marin-Franch2, 3, H. Radhakrishnan1, N. Lopez-Gil3. 1Optometry, The University of Manchester, Manchester, United Kingdom; 2Óptica y Optometría y Ciencias de la Visión, Universitat de València, Valencia, Spain; 3Ciencias de la Visión research group, Universidad de Murcia, Murcia, Spain 3126 — B0131 Subjective preference to orientation of an angular bifocal IOL design. Aiswaryah Radhakrishnan, C. Dorronsoro, S. Marcos. Instituto de Optica, CSIC, Madrid, Spain *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 220 Tuesday – Posters – 3127 – 3144 3127 — B0132 Preclinical evaluation of tolerance to astigmatism with an extended range of vision IOL. Carmen Canovas, A. Alarcon, J. Graver, H. A. Weeber, P. A. Piers. R&D, AMO Groningen B.V., Groningen, Netherlands *CR 3128 — B0133 Testing vision with physical and simulated multifocal corrections in an adaptive optics visual simulator. Maria Vinas1, C. Dorronsoro1, A. Radhakrishnan1, E. LaVilla2, J. Schwiegerling2, S. Marcos1. 1Instituto de Optica (CSIC), Madrid, Spain; 2College of Optical Sciences. University of Arizona, Tucson, AZ 3129 — B0134 Eye Tracker with Distance Measurement for Autofocus Eyeglass. Zengzhuo Li2, 1, G. Li2, 1. 1Electrical and computer engineering, The Ohio State University, Columbus, OH; 2 Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, OH 3131 — B0136 Design and evaluation of a surface-changing accommodating IOL. Andres De La Hoz1, E. Martinez-Enriquez1, H. Subhash1, D. Pascual1, N. Bekesi1, C. Dorronsoro1, N. AlejandreAlba1, 2, S. Marcos1. 1Instituto de Optica, CSIC, Madrid, Spain; 2Fundación Jimenez Díaz, Madrid, Spain *CR Exhibit/Poster Hall B0232-B0270 Tuesday, May 03, 2016 8:30 AM-10:15 AM Genetics Group 319 Retinal Genetics Moderators: Jacque L. Duncan and Carlo Rivolta 3132 — B0232 A tandem duplication of PRDM13 in a family with North Carolina Macular Dystrophy (MCRD1). Lori S. Sullivan1, S. J. Bowne1, D. C. Koboldt2, R. S. Fulton2, K. G. Locke3, K. D. Webb-Jones3, D. K. Wheaton3, R. K. Wilson2, D. G. Birch3, S. P. Daiger1, 4. 1Human Genetics Center, Univ Texas Hlth Sci Ctr Houston, Houston, TX; 2The Genome Institute, Washington University School of Medicine, St. Louis, MO;3Retina Foundation of the Southwest, Dallas, TX; 4Ruiz Dept. of Ophthalmology, Univ Texas Hlth Sci Ctr Houston, Houston, TX 3134 — B0234 SRD5A3: a gene for complex LCA and early onset retinal dystrophy. Elise Heon1, 2, S. Li2, 1, E. Tavares2, 1, H. Macdonald1, A. Vincent1. 1Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada; 2 Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada 3135 — B0235 Complex Multi-Allelic Inherited Retinal Dystrophy: Multiple Genes Contributing Independently and Concurrently in Extended Families. Dianna K. Wheaton1, 4, K. D. WebbJones1, S. J. Bowne2, L. S. Sullivan2, R. Chen3, S. P. Daiger2, D. G. Birch1, 4. 1Retina Foundation of the Southwest, Dallas, TX; 2Univ Texas Health Science Center, Houston, TX; 3Baylor College of Medicine, Houston, TX; 4Ophthalmology, Univ Texas Southwestern Medical Center, Dallas, TX 3136 — B0236 Heterogeneity and complexity of EYS mutations in autosomal recessive retinitis pigmentosa in northern Sweden. Irina Golovleva1, F. Jonsson1, M. Burstedt2. 1Medical Biosciences, Umeå University, Umea, Sweden; 2Clinical Sciences, Umeå University, Umeå, Sweden 3137 — B0237 Exome Analysis Detected a Novel 7.4 kb Deletion in the PRPH2 Gene as the Underlying Cause of Recessive Retinal Degeneration in a Consanguineous Family. Kameron Kishaba1, P. Biswas1, J. Suk1, I. Ullah2, M. A. Naeem2, S. Riazuddin2, 3, J. Akram3, 4, J. Hejtmancik5, S. Riazuddin6, R. Ayyagari1. 1Shiley Eye Institute, University of California, San Diego, La Jolla, CA; 2National Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan; 3Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan; 4 National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan; 5OMGS/OGVFB, National Eye Institute, NIH, Bethesda, MD; 6The Wilmer Eye Institute, John’s Hopkins University School of Medicine, Baltimore, MD 3138 — B0238 Phenotypic Variability in RDH12 Retinopathy. Ruifang Sui1, X. Zou1, Z. Ge2, H. Li1, M. Xu2, R. Chen2, F. Dong1. 1Ophthalmology, Peking Union Med College Hosp, Beijing, China; 2 Molecular and Human genetics, Baylor College of Medicine, Houston, TX 3139 — B0239 A mutation in Adiponectin receptor 1 causes autosomal-dominant retinitis pigmentosa. Liping Yang. Peking University Eye Center, Peking University Third Hospital, Beijing, China 3140 — B0240 Mutation analysis of RHO gene in 225 Chinese families with retinitis pigmentosa. Jianjun Chen2, 1, L. Han2, 1, Z. Fan2, 1, Z. Wu2, 1, Z. Zhong2, 1. 1Tongji University, Shanghai, China;2Shanghai Tenth People’s Hospital, Shanghai, China 3141 — B0241 Two distinct phenotypes in the same family are caused by the Schiff base counterion mutation p.E113K in rhodopsin. Marta Owczarek-Lipska1, C. Reiff2, G. Spital3, C. Roeger1, H. Hinz1, C. Jüschke1, H. Thiele4, J. Altmüller4, P. Nürnberg4, R. Da Costa1, J. Neidhardt1. 1Human genetics, University of Oldenbrug, Oldenburg, Germany; 2Eye Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany;3Ophthalmology, St. Franziskus-Hospital, Münster, Germany; 4Cologne Center for Genomics, University of Cologne, Cologne, Germany 3142 — B0242 Autosomal dominant Retinitis Pigmentosa caused by a deletion not reported in the human rhodopsin gene: a case report. Maria Moussalli. Ophthalmology, Hospital Italiano, Capital Federal, Argentina 3143 — B0243 Identification of the first CHM promoter mutation in a patient with choroideremia. Alina Radziwon, I. M. MacDonald. Ophthalmology, University of Alberta, Edmonton, AB, Canada 3144 — B0244 Identification of a novel frame-shift deletion in the CHM gene in a consanguineous family. Aditya A. Guru1, P. Biswas1, J. Suk1, K. Kishaba1, I. Ullah2, M. A. Naeem2, S. Riazuddin2, 3, S. Riazuddin4, R. Ayyagari1, J. Hejtmancik5. 1Shiley Eye Institute, UCSD, San Diego, CA; 2National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan; 3Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan; 4The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 5 OMGS/OGVFB, National Eye Institute, NIH, Bethesda, MD *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 221 Tuesday Posters 8:30 am – 10:15 am 3130 — B0135 The Effect of Peripherally Positioned Capsulorhexis in Phaco Ersatz studied using 3D Finite Element Model. Hooman Mohammad Pour1, 2, S. Devineni2, S. Kanapathipillai2, F. Manns3, 4, A. Ho1, 5. 1Brien Holden Vision Institute, Kensington, NSW, Australia; 2Mechanical and Manufacturing Engineering, University of New South Wales, Kensington, NSW, Australia; 3Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL; 4Department of Biomedical Engineering, Biomedical Optics and Laser Laboratory, University of Miami, Miami, FL; 5School of Optometry and Vision Science, University of New South Wales, Kensington, NSW, Australia 3133 — B0233 North Carolina Macular Dystrophy (NCMD / MCDR1) mutations found; PRDM13. Kent W. Small1, A. P. DeLuca5, F. P. Cremers3, C. Hoyng3, M. J. Leys2, B. Bakall6, R. A. Lewis4, R. Silva-Garcia1, K. Rohrschneider7, E. M. Stone5, 8. 1Molecular Insight, Research Foundation, Glendale, CA; 2cell biology, neurology and anatomy, WVU Eye Institute, Morgantown, WV; 3Biology, Raboud University Medical Center, Nijmegen, Netherlands; 4Baylor College of Medicine, Houston, TX; 5Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, Iowa City, IA; 6Associated Retina Consultants, University of Arizona College of Medicine, Phoenix, AZ; 7 University of Heidelberg, Heidelberg, Germany; 8 The Stephen A. Wynn Institute for Vision Research, Iowa City, IA 3145 – 3163 – Tuesday – Posters 3145 — B0245 Variable expression of TIMP3related maculopathy due to an atypical mutation in a large family. Jerry Lee1, R. Sisk2, C. Linne3, L. Krueger4, S. Schoenberger5, L. Fritsche6, E. Y. Chew7, B. P. Brooks1, A. Agarwal8, Z. Ahmed9, R. B. Hufnagel1. 1Ophthalmic Genetics and Visual Function Branch, National Eye Institute (NEI/NIH), Bethesda, MD; 2Cincinnati Eye Institute, Cincinnati, OH; 3Washington University, St. Louis, MO; 4 University of Kentucky, Lexington, KY; 5Retina Physicians and Surgeons, Dayton, OH; 6University of Michigan, Ann Arbor, MI; 7National Eye Institute (NEI/NIH), Bethesda, MD; 8Vanderbilt University, Nashville, TN; 9University of Maryland, Baltimore, MD Tuesday Posters 8:30 am – 10:15 am 3146 — B0246 Challenges in the diagnosis of autosomal recessive bestrophinopathy: additional case reports. Benedikt Book1, H. B. Stoehr2, B. H. Weber2, G. Spital1. 1Department of Ophthalmology, St. Franziskus Hospital Muenster, Muenster, Germany; 2Institute of Human Genetics, University Regensburg, Regensburg, Germany *CR 3147 — B0247 Novel genetic variants causing hereditary vitreoretinopathies. Diem K. Bui1, N. Jain1, G. B. Hubbard1, S. Shankar1, 2. 1 Ophthalmology, Emory Eye Center, Atlanta, GA; 2 Department of Human Genetics, Emory University, Atlanta, GA 3148 — B0248 Frmd4b Suppresses Retinal Dysplasia in Nr2e3rd7 Mice by Restoring the Integrity of External Limiting Membrane. Yang Kong1, 2, J. R. Charette1, J. Naggert1, L. Zhao1, P. M. Nishina1, 2.1The Jackson Laboratory, Bar Harbor, ME; 2The Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME 3149 — B0249 Zebrafish and Mouse Models with Mutations in the Novel Gene ASRGL1 Develop Retinal Degeneration (RD) Recapitulating the Human Phenotype. Pooja Biswas1, V. R. Chavali2, N. W. Khan3, J. Suk1, M. Homsher2, S. Riazuddin4, 5, J. Hejtmancik6, S. Riazuddin7, R. Ayyagari1. 1Shiley Eye Institute, University of California San Diego, La Jolla, CA; 2 Ophthalmology, University of Pennsylvania, Philadelphia, PA;3W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI; 4National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan; 5Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan; 6OMGS/OGVFB, National Eye Institute, NIH, Bethesda, MD; 7The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 3151 — B0251 Generation and characterization of Fam161a Conditional Knockout mice. Avigail Beryozkin1, A. Obolensky1, S. Meyer1, A. Ejzenberg1, C. Matsevich1, Y. Arsenijevic2, C. Rivolta2, E. Banin1, D. Sharon1. 1Ophthalmology, HadassahHebrew University Medical Center, Jerusalem, Israel; 2University of Lausanne, Lusanne, Switzerland 3152 — B0252 A spontaneous Kunming mouse for Usher syndrome caused by homozygous mutations of Ush2a and Pde6b. Zuoming Zhang2, 1, L. Zhang2, L. Yao2, J. Xue2. 1Ophthalmology & Visual Science, Fourth Military Medical Univ, Xi’an, China; 2Clinical Aerospace Medicine, Fourth Military Medical University, Xi’an, China 3153 — B0253 Whole exome sequencing reveals a homozygous splicing mutation in CEP78 as the cause of atypical Usher syndrome in Eastern Jewish patients. Dror Sharon1, P. Namburi1, R. Ratnapriya2, C. Lazar2, A. Obolensky1, T. Ben-Yosef3, E. Pras4, M. Gross5, E. Banin1, A. Swaroop2. 1Ophthalmology, HadassahHebrew Univ Medical Ctr, Jerusalem, Israel; 2 Neurobiology-Neurodegeneration & Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, MD; 3The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; 4Ophthalmology, Assaf Harofeh Medical Center, Zerifin, Israel;5Department of Otolaryngology - Head and Neck Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Jerusalem, Israel 3154 — B0254 The Genetics of Usher Syndrome in the Israeli and Palestinian Populations. Samer Khateb1, A. Khalaileh1, T. BenYosef2, A. Raas-Rothschild2, I. Chowers1, E. Banin1, D. Sharon1. 1Genetics Department, Meir Medical Center, Kfar Saba, Israel; 2Genetics department, Technion-Israel Institute of Technology, Haifa, Israel 3155 — B0255 HDAC1/2 are critical for RPE homeostasis and health. Mark E. Kleinman, K. Jung, J. Roney, S. C. Prajapati, D. Lou, S. Dubey, J. Brown, K. Mohan. Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY *CR 3156 — B0256 Genetic Testing Based on Next Generation Sequencing (NGS) for Retinitis Pigmentosa (RP) in Brazilian Patients. Juliana M. Sallum1, K. A. Costa1, M. Salles1, J. P. Chiang2. 1 Ophthalmology, UNIFESP, Sao Paulo, Brazil; 2 Genetic Eye Diseases, Oregon Health Sciences University, Portland, OR 3150 — B0250 A new mouse model of cone photoreceptor function loss (cpfl9) with cone photoreceptor degeneration. Bo Chang, J. Wang, B. FitzMaurice. Ophthalmology, The Jackson Laboratory, Bar Harbor, ME 3157 — B0257 Diagnostic Utility of a Next Generation Sequencing Retinal Panel in a Māori and Polynesian population with Inherited Retinal Disease. Andrea L. Vincent1, 2, A. Coysh1, K. Van Bysterveldt1, V. F. Oliver1, G. C. Black3. 1 Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand; 2Eye Department, Greenlane Clinical Centre, Auckland District Health Board, Auckland, New Zealand; 3Manchester Centre for Genomic Medicine, Institute of Human Development, University of Manchester, Manchester, United Kingdom 3158 — B0258 Comprehensive Molecular Diagnosis of a Large Chinese Patient Cohort With Autosomal Dominant Retinitis Pigmentosa. Fei Xu1, 2, M. Xu3, Z. Sun1, Z. Ge3, H. Li1, Y. Li3, L. Yang1, H. Zhang2, F. Dong1, R. Chen3, R. Sui1. 1 ophthalmology, Peking Union Medical College Hospital, Beijing, China; 2Ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China; 3Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 3159 — B0259 Phenotype Based Targeted Next Generation Sequencing Complemented with Microarray Analysis has high yield in Clinical Genetic Testing of Inherited Eye Disorders. Suma P. Shankar1, 2, J. Yan2, S. Richards1, B. Bunke1, M. Hegde1, J. Alexander1. 1Human Genetics, Emory University School of Medicine, Atlanta, GA; 2 Ophthalmology, Emory University School of Medicine, Atlanta, GA 3160 — B0260 Retinal panel exome sequencing- a diagnostic tool to hereditary retinal disorders. Dinesh Kumar Kandaswamy1, 2, M. Prakash3, J. Graw2, S. T. Santhiya1. 1Department of Genetics, Dr ALM PG IBMS, University of Madras, Chennai, India; 2Institute of Developmental Genetics, Helmholtz Zentrum Munchen, Munich, Germany; 3Retinal Unit, Regional Institute of Ophthalmology, Egmore Eye Hospital, Chennai, India 3161 — B0261 RetDegenDx: A retinal dystrophy genetic diagnosis prediction tool. Dana Schlegel1, B. Katz2, V. Bichucher2, R. Starbuck2, W. Xu2, J. Durrah2, E. Al-Sharif1, A. DeOrio2, N. W. Khan1, K. T. Jayasundera1. 1Retinal Dystrophy, Kellogg Eye Center, Ann Arbor, MI; 2University of Michigan, Ann Arbor, MI 3162 — B0262 Unfolding mutation screen for inherited eye disease. Caitlyn McCafferty, Y. V. Sergeev. National Eye Institute, National Institutes of Health, Washington DC, DC 3163 — B0263 In-silico unfolding: a role of missense changes in Stargardt’s disease. Yuri V. Sergeev1, C. McCafferty1, K. Fujinami2, B. Falsini1, 3, W. M. Zein1, K. T. Jayasundera4, M. Michaelides5, B. P. Brooks1, P. A. Sieving1. 1 OGVFB, National Eye Institute, Bethesda, MD; 2 National Institute of Sensory Organs, Tokyo, Japan; 3Catholic Medical University, Rome, Italy; 4University of Michigan, Ann Arbor, MI; 5 Moorfields Eye Hospital, London, United Kingdom The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 222 Tuesday – Posters – 3164 – 3181 3164 — B0264 Influence of Risk Alleles for Age-Related Macular Degeneration on Recessive Stargardt Disease Phenotypes. Robert Sisk1, 2, R. B. Hufnagel3, B. Zanke4, Z. Ahmed3. 1Ophthalmology, University of Cincinnati, Cincinnati, OH; 2Ophthalmology, Cincinnati Children’s Hospital, Cincinnati, OH; 3Otolaryngology, University of Maryland, Baltimore, MD; 4Arctic Dx, Bonita Springs, FL *CR 3165 — B0265 A combination of oculopharyngeal muscular dystrophy and a variant of enhanced S-cone syndrome in Bukharan Jews due to linked mutations in PABPN1 and NRL. Tamar Ben-Yosef1, H. Newman2, I. Braverman3, 1, S. Blumen3, 1, R. Hanna3, B. Tiosano3, I. Perlman1, 2. 1Technion, Haifa, Israel; 2 Ophthalmology, Tel-Aviv Medical Center, Tel Aviv, Israel; 3Hillel Yaffe Medical Center, Hadera, Israel 3166 — B0266 Interrogating the M/L Opsin Cluster using Exome Sequencing. Adam P. DeLuca, S. Whitmore, R. M. Johnston, J. S. East, H. T. Daggett, J. M. Hoffmann, T. E. Scheetz, E. M. Stone. Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA 3168 — B0268 Quantitative Analysis of Photoreceptor Swelling in Late-Onset Retinal Degeneration Using Adaptive Optics. Jianfei Liu, C. A. Cukras, J. Tam. National Eye Institute, National Institutes of Health, Bethesda, MD 3169 — B0269 How multimodal retinal imaging can help with Next Generation Sequencing interpretation: the example of cone and cone-rod dystrophies. Elise BoulangerSemama1, 3, S. El Shamieh2, S. Mohand-Said2, 3 , V. Démontant2, C. Condroyer2, A. Antonio2, C. Michiels2, F. Boyard2, J. Sahel2, 3, C. Zeitz2, I. S. Audo2, 3. 1Ophthalmology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; 2INSERM, U968, CNRS, UMR_7210, Sorbonne Universités, UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, F-75012, France; 3DHU ViewMaintain, INSERM-DHOS CIC 1423, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, F-75012, France Exhibit/Poster Hall B0271-B0300 3175 — B0275 Retinal degeneration associated with transition zone protein MKS6. Katie L. Bales1, W. R. Lewis3, B. K. Yoder3, R. A. Kesterson2, A. K. Gross1. 1Vision Science, University of Alabama at Birmingham, Birmingham, AL; 2 Genetics, University of Alabama, Birmingham, AL; 3Cellular, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 3176 — B0276 RPE cell specific loss of ERK1/2 leads to retinal degeneration. Aswin Pyakurel1, 3, D. Balmer3, M. L. Zhu4, M. Saba El Leil5, J. Daraspe6, B. Humbel6, L. Voisin5, Y. Le4, J. Von Lintig2, S. Meloche5, R. Roduit1, 3. 1Hopital ophtalmique Jules-Gonin, University of Lausanne, Lausanne, Switzerland; 2School of Medicine, Case Western Reserve University, Cleveland, OH; 3 Institute for Research in Ophthalmology, Sion, Switzerland; 4University of Oklahoma Health Sciences Center, Oklahama, OK; 5Université de Montréal, Montreal, QC, Canada; 6University of Lausanne, Lausanne, Switzerland Moderators: Isabelle S. Audo and Marina S. Gorbatyuk 3177 — B0277 Elucidating the role of Retinal Pigment Epithelium (RPE)-specific ABCA4 in Stargardt disease. Tamara L. Lenis1, Z. Jiang1, S. Sarfare2, A. Le1, S. Eddington1, D. Bok1, R. S. Molday3, S. Nusinowitz1, M. Redmond4, G. H. Travis1, R. A. Radu1. 1Stein Eye Institute, UCLA, Los Angeles, CA; 2Ora, Inc., Andover, MA; 3 University of British Columbia, Vancouver, BC, Canada; 4National Eye Institute, Bethesda, MD 3171 — B0271 The USH1G scaffold protein SANS is part of the cytoplasmic dynein transport module in the photoreceptor inner segments. Uwe Wolfrum1, N. Sorusch1, K. Boldt2, M. Ueffing2, K. A. Wunderlich1. 1Cell and Matrix Biology, Johanne Gutenberg University of Mainz, Mainz, Germany; 2Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany 3178 — B0278 Membrane-type Frizzled Related Protein (MFRP) is needed for photoreceptor cell function by retaining docosahexaenoic acid (DHA). Nicolas G. Bazan1, B. Jun1, B. Chang2, W. C. Gordon1.1Neuroscience Center of Excellence, Louisiana State University Health, New Orleans, LA; 2The Jackson Laboratory, Bar Harbor, ME 3172 — B0272 Changes in RDS/Peripherin-2 binding properties and complex formation underlie macular dystrophy. Rahel S. Zulliger1, S. M. Conley2, D. Chakraborty2, M. W. Stuck2, M. I. Naash1.1Biomedical Engineering, University of Houston, Houston, TX; 2University of Oklahoma Health Sciences Center, Oklahoma City, OK 3179 — B0279 Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms. Alexander Marneros. Massachusetts General Hospital, Charlestown, MA; Harvard Medical School, Boston, MA Tuesday, May 03, 2016 8:30 AM-10:15 AM Biochemistry/Molecular Biology 320 Molecular and biochemical mechanisms of retinal disease 3173 — B0273 Identification of possible target binding site in retinal degeneration 3 (RD3) protein. Igor V. Peshenko, E. V. Olshevskaya, A. M. Dizhoor. Research, Salus University, Elkins Park, PA 3174 — B0274 Clinical, genetic and functional study of ABCA4 mutations in Stargardt patients. Kailun Jiang1, L. L. Molday1, H. B. Stoehr2, B. H. Weber2, D. Maberley1, R. S. Molday1. 1University of British Columbia, Coquitlam, BC, Canada; 2 University of Regensburg, Regensburg, Germany *CR 3180 — B0280 Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors. Elena V. Olshevskaya1, S. L. Boye2, K. T. McCullough2, I. V. Peshenko1, S. E. Boye2, A. M. Dizhoor1. 1 Research, Salus University, Elkins Park, PA; 2 Ophthalmology, University of Florida, Gainesville, FL *CR 3181 — B0281 Role of Complement-1q Tumor Necrosis Factor Related Protein 5 (CTRP5/ C1QTNF5) in Late-Onset Retinal Degeneration (L-ORD) Pathology. Shruthi Karnam1, V. R. Chavali2, G. Reddy3, R. Ayyagari1. 1Shiley Eye Institute, University of California San Diego, La Jolla, CA; 2Ophthalmology, University of Pennsylvania, Philadelphia, PA; 3National Institute of Nutrition, Hyderabad, India f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 223 Tuesday Posters 8:30 am – 10:15 am 3167 — B0267 Investigations for the underlying genetic cause in a consanguineous family with complete achromatopsia. Markus N. Preising, A. Zuliani, B. Lorenz. Department of Ophthalmology, Justus-Liebig University, Giessen, Germany 3170 — B0270 Implications of retinal imaging for identification of Danon disease patients. Bohdan Kousal1, 2, F. Majer2, H. Vlaskova2, L. Dvorakova2, T. Palecek5, M. Kubanek3, V. Stara4, J. Sikora2, P. Liskova1, 2. 1Department of Ophthalmology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic; 2Institute of Inherited Metabolic Disorders; First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic; 3Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 4Pediatric Clinic, Second Faculty of Medicine, Charles University in Prague and Faculty Hospital Motol, Prague, Czech Republic; 5 Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic 3182– 3202 – Tuesday – Posters 3182 — B0282 Genetic dissection of rod and cone contributions to the ERG in the living mouse. Gabriel Peinado2, K. E. Ronning2, R. Herrmann2, M. E. Burns2, 3, E. N. Pugh1, 3. 1Cell Biology and Human anatomy, UC Davis, Davis, CA; 2 Center for Neuroscience, UC Davis, Davis, CA; 3 Ophthalmology and Vision Science, UC Davis, Davis, CA Tuesday Posters 8:30 am – 10:15 am 3183 — B0283 Functional Diversity of Human ATF6 Mutations Associated with Achromatopsia. Wei-Chieh Chiang1, P. Chan1, S. Kohl2, A. Vincent3, A. Skorczyk-Werner4, M. R. Krawczynski4, S. H. Tsang5, E. Heon3, B. Wissinger2, J. H. Lin1. 1Pathology, University of California, San Diego, La Jolla, CA; 2Institute for Ophthalmic Research, University of Tubingen, Tubingen, Germany; 3Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; 4Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland; 5Department of Ophthalmology, Columbia University, New York, NY 3184 — B0284 A Biochemical Analysis of the Living Human Vitreous. Jan Kokavec, S. H. Min, M. H. Tan, J. S. Gilhotra, H. S. Newland, S. R. Durkin, R. J. Casson. South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, SA, Australia 3185 — B0285 Lipidomic and Proteomic Characterization of Subretinal Fluid in Coats Disease. Lisa M. Lagrou1, M. D. Pawar1, A. Capone, Jr.2, M. T. Trese2, C. G. Besirli1. 1Kellogg Eye Center/Ophthalmology, University of Michigan, Ann Arbor, MI; 2Associated Retinal Consultants, Royal Oak, MI 3186 — B0286 Observed versus predicted exon 3 skipping in OPN1LW using a hexamer-linearadditive model (HAL). Maureen Neitz, J. Neitz, J. Rowlan, C. Davidoff. Ophthalmology, University of Washington, Seattle, WA 3187 — B0287 Sphingosine kinase 2 induces angiogenic effects by enhancing neovascularisation in the mouse model of retinopathy of prematurity. Jeanette Christophel1, L. Hattenbach3, J. Pfeilschifter1, W. Pfeilschifter2. 1 Dep. of General Pharmacology and Toxicology, Goethe University Hospital, Frankfurt/Main, Germany; 2Dep. of Neurology, Goethe University Hospital, Frankfurt/Main, Germany; 3Department of Ophthalmology, Ludwigshafen Hospital, Ludwigshafen, Germany *CR 3188 — B0288 Photoreceptor structure and gene expression in the canine NPHP5-LCA ciliopathy model. Louise M. Downs, E. M. Scott, S. Genini, W. A. Beltran, G. D. Aguirre. University of Pennsylvania, School of Vetinary Medicine, Philadelphia, PA 3189 — B0289 Embryonic chick retinal cell cultures: a model for Light-Induced Retinal Degeneration (LIRD). Robin H. Schmidt1, N. F. Henneman1, P. E. Girardot1, S. W. Gooding1, P. P. Cunha1, J. H. Boatright1, 2. 1Ophthalmology, Emory University, Atlanta, GA; 2Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA 3190 — B0290 Serum Hyperhomocystinemia: A Risk Factor for Retinal Vein Occlusions. Neha R. Chandak, S. Banait, S. Daigavane. Ophthalmology, Datta Meghe Institute of Medical Sciences, Nagpur, India 3191 — B0291 Localization and Functional Analysis of ABCA4 Variants Associated with Stargardt Disease. Laurie L. Molday1, R. Allikmets2, R. S. Molday1. 1Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada; 2Ophthalmology, Columbia University, New York City, NY 3192 — B0292 Investigating the pathomechanism of FAM161A-associated retinal disease in primary ciliated cells. Heidi B. Stoehr1, M. Schwarzfischer1, L. Braun1, A. Aslanidis2, T. Langmann2, U. Kellner3, 4. 1Human Genetics, University Regensburg, Regensburg, Germany; 2Laboratory for Experimental Immunology of the Eye, University Cologne, Cologne, Germany; 3MVZ ADTC Siegburg GmbH, Rare Retinal Disease Center, Siegburg, Germany; 4 RetinaScience, Bonn, Germany 3193 — B0293 RPGR, a retinal ciliopathy protein, localizes to cilia in a prenylation dependent manner. Wei Zhang, N. R. Kollu, L. Li, M. Anand, H. Khanna. Ophthalmology, University of Massachusetts Medical School, Worcester, MA 3194 — B0294 Whole transcriptome sequencing in rd10 revealed new factors and pathways involved in stem cells biology and neuroprotection in the inner retina and ciliary body. Jerome E. Roger1, L. Gieser2, M. Barnes1, A. Hamon1, C. Masson-Garcia1, M. Perron1, 3. 1CERTO / Neuro-PSI, Orsay, France; 2NEI / NIH, Bethesda, MD; 3CNRS, Orsay, France 3195 — B0295 MicroRNA-124-3p Represses Retinal Pigment Epithelial Cells Proliferation and Migration by Targeting RhoG. JongHwa Jun. Ophthalmology, Dongsan Medical Center, Keimyung University, Daegu, Korea (the Republic of) 3196 — B0296 A PAR-ting Gift: 3-Aminobenzamide attenuates PARP-1dependent cell death induced by Melphalan in a Retinoblastoma cell line. Brittany Townley1, 2, M. K. Krevosky2, J. Bowen2.1National Cancer Institute, National Institutes of Health, Bethesda, MD; 2Biology, Bridgewater State University, Bridgewater, MA 3197 — B0297 MicroRNA-21 Implicated in Down-Regulation of PPAR-α in Diabetic Retinopath. Yusuke Takahashi1, 2, Q. Chen3, 2, F. Qiu3, E. Moran3, 2, M. H. Greg3, 2, K. Zhou3, R. V. Rajala3, 4, J. Ma3, 2.1Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2Harold Hamm Diabetes Center, Oklahoma City, OK; 3Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK;4Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 3198 — B0298 Optical Sensing of Molecular Structure in Vitreous of Patients with Decreased Contrast Sensitivity. Matin Khoshnevis1, 2, A. Sampathkumar4, G. A. Garcia1, 2, J. Sebag1, 3. 1VMR Institute for Vitreous Macula Retina, Huntington Beach, CA; 2School of Medicine, University of California, Irvine, Irvine, CA; 3Ophthalmology, Doheny Eye Institute/UCLA, Los Angeles, CA; 4 Electromagnetic Sciences, Lizzi Center for Biomedical Engineering, Riverside Research, Dayton, OH 3199 — B0299 Investigation of VEGF165 induced retinal vascular inflammation in vitro. Ashley Mackey, Y. Ng. Ophthalmology, Schepens Eye Research Institute/Mass Eye and Ear, Boston, MA 3200 — B0300 Oxidative stress, autophagy, and exosome liberation in retinal pigment epithelium cells. Sandra Atienzar, G. Serrano, N. Martinez, D. López, L. Vidal, N. Morillas, A. Urdaneta, B. Prieto, J. Barcia, F. Sancho, F. Rómero. Phisiology, Catholic University of Valencia, Valencia, Spain Exhibit/Poster Hall C0001-C0038 Tuesday, May 03, 2016 8:30 AM-10:15 AM Retinal Cell Biology 321 Diabetic Retinopathy Moderator: Julia V. Busik 3201 — C0001 Photoreceptor distortion accompanies inner retina degeneration and loss of visual function in streptozotocin-diabetic rats. Alistair J. Barber, Z. Nasralah. Ophthalmology, Penn State Hershey College of Medicine, Hershey, PA 3202 — C0002 Molecular mechanisms underlying the mechanical control of retinal endothelial activation associated with diabetes. Kaustabh Ghosh1, X. Yang1, A. Bhaskaran1, A. Das2, T. S. Kern3.1Bioengineering, University of California, Riverside, Riverside, CA; 2 Ophthalmology, University of New Mexico, Albuquerque, NM; 3Medicine, Case Western Reserve Univ, Cleveland, OH *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 224 Tuesday – Posters – 3203 – 3224 3203 — C0003 The Role Of Acid Sphingomyelinase In Shifting The Balance Between Pro-inflammatory And Reparative Bone Marrow Cells In Diabetic Retinopathy. Walter V. Esselman1, H. Chakravarthy2, S. N. Navitskaya2, S. V. O’Reilly2, E. Beli3, Q. Wang2, N. Kady2, C. Huang2, M. B. Grant3, J. V. Busik2. 1College of Human Medicine, Michigan State University, East Lansing, MI; 2Physiology, Michigan State University, East Lansing, MI; 3Ophthalmology, Indiana University, Indianapolis, IN 3211 — C0011 miR15a/16 mediates protective effects of beta-adrenergic signaling to reduce leukostasis in diabetic retinopathy. Li Liu, E. Ye, J. J. Steinle. Anatomy and Cell Biology, Wayne State University, Detroit, MI 3204 — C0004 A novel role of poly(ADPribose) polymerase 1 in mitochondrial damage in diabetic retinopathy. Manish Mishra, R. A. Kowluru. Ophthalmology, Kresge Eye Institute, Detroit, MI 3213 — C0013 12/15 lipoxygenase and Vascular Endothelial Growth Factor Signaling in Retinal Cells. Nehal M. Elsherbiny1, 2, A. Ibrahim1, 2, H. M. Saleh1, K. Hussein1, K. Elmasry5, N. Sheibani3, M. A. Al-Shabrawey1, 4. 1Oral Biology and Anatomy, College of Dental medicine, Augusta university, Augusta, GA; 2Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; 3 Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI; 4The Culver Vision Discovery Institute, Georgia Regents University, Augusta, GA; 5Cellular Biology and Anatomy, Medical college of Georgia, Augusta University, Augusta, GA 3205 — C0005 Effect of Hyperglycemia on Circadian Rhythm of Human Retinal Vascular Endothelial Cells. Sankarathi Balaiya, K. Chalam. Ophthalmology, University of Florida College of Medicine, Jacksonville, FL 3207 — C0007 Inhibiting VEGF Signaling by Targeting Receptor Trafficking in Diabetic Retinopathy. Weiquan Zhu, D. S. Shi, J. Winter, B. Rich. Department of Internal Medicine, University of Utah, Salt Lake City, UT 3208 — C0008 The Tumor Necrosis Factor α (TNF-α) Disturbs Kir4.1 Rhythm in Muller Cells. Ashay D. Bhatwadekar1, I. Hassan1, S. Majumdar1, V. Jadhav1, J. V. Busik2. 1 Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indianapolis, IN; 2Department of Physiology, Michigan State University, East Lansing, MI 3209 — C0009 Sphingosine-1-Phosphate demonstrates anti-angiogenic and antiinflammatory properties. Carolina Franco Nitta1, 2, F. Monickaraj1, S. Rangasamy4, P. McGuire3, A. Das1, 2. 1Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM; 2 Surgery, NMVA Health Care System, Albuquerque, NM; 3Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM;4Translational Genomics Research Institute, Phoenix, AZ 3210 — C0010 Possible involvement of aquaporin 4 and nitric oxide in the high glucoseinduced swelling of Muller cells in rat retina. Teruyo Kida, H. Oku, M. Fukumoto, Y. Okuda, S. Morishita, T. Horie, H. Suzuki, T. Kobayashi, T. Ikeda. Ophthalmology, Osaka Medical College, Takatsuki, Japan 3214 — C0014 Potential of Human Donor Tissues for Discovery and Targeted Research on Diabetic Retinopathy. Patrice E. Fort1, 2, Y. Qi1, A. Myers1. 1Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; 2Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 3215 — C0015 The relationship between retinal blood flow, neuronal function and glia in the early diabetic retina,. Samuel A. Mills1, A. I. Jobling1, B. V. Bui2, Z. He2, U. Greferath1, J. Wang2, F. Hui2, E. L. Fletcher1. 1Anatomy and Neuroscience, The University of Melbourne, Melbourne, VIC, Australia; 2Optometry and Vision Science, The University of Melbourne, Melbourne, VIC, Australia 3216 — C0016 NOX4 Stabilizes Barrier Function of Human Retinal Endothelial Cells and Retinal Pigment Epithelial Cells. Heba M. Saleh1, 2, K. Hussein1, 5, A. S. Ibrahim1, 4, K. Elmasry3, 2, N. M. El-Sherbiny1, 4, D. Fulton6, 7, M. A. Al-Shabrawey1, 2. 1Oral Biology and Anatomy, Dental College of Georgia, Augusta University, Augusta, GA; 2Culver Vision Discovery Institute and Ophthalmology, Medical College of Georgia, Augusta University, Augusta, GA; 3Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA; 4Biochemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; 5Oral and Dental Research Division, Department of Surgery and Medicine, National Research Center, Cairo, Egypt; 6Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA; 7 Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 3218 — C0018 Elevated homocysteine in the vitreous of diabetic patients and blood of type 1 and 2 diabetic animal models; Potential role of homocysteine in blood retinal barrier dysfunction. Isha Sharma, A. S. Ibrahim, H. M. Saleh, S. Rizwan, G. I. Liou, M. A. Al-Shabrawey, A. M. Tawfik. augusta university, Augusta, GA 3219 — C0019 Activated Monocytes Contribute to the Mechanical Control of Diabetic Retinal Endothelial Activation. Arun Bhaskaran, X. Yang, H. Scott, K. Ghosh. Department of Bioengineering, University of California, Riverside, Riverside, CA 3220 — C0020 Rho/ROCK-mediated Retinal Endothelial Stiffening Impairs TRPV4 Signaling and Promotes Diabetic Retinal Inflammation. Xiao Yang1, A. Bhaskaran1, H. Scott1, S. Ardekani1, J. Xu2, U. Mohideen2, T. S. Kern3, K. Ghosh1. 1 Bioengineering, University of California, Riverside, Riverside, CA; 2Physic, University of California, Riverside, Riverside, CA; 3Case Western Reserve University, Cleveland, OH 3221 — C0021 Measurement of acute vascular permeability and associated signaling in ex vivo rat retinae. Eleni Karatsai, M. B. Powner, S. Dragoni, P. Turowski. UCL, London, United Kingdom 3222 — C0022 Detailed quantitative and qualitative evaluation of potential ganglion cell pathology in the retina of Zucker Diabetic Fatty (ZDF) Rats. Akos Lukats1, K. Szabo1, A. Enzsoly1, 2, A. Szabo1, A. Szel1, B. Dekany1, G. M. Somfai2, K. Laurik2, 1, T. Radovits3, C. Matyas3, R. I. Hajdu1, 2. 1 Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary; 2 Department of Ophthalmology, Semmelweis University, Budapest, Hungary; 3Heart Center, Semmelweis University, Budapest, Hungary 3223 — C0023 Up-regulation of SLC2A9 (Glut9) in normal and diabetic human retina implicates altered urate transport in diabetesinduced retinal barrier dysfunction. Manuela Bartoli1, D. Gutsaeva1, M. Thounaojam1, P. M. Martin2, F. Lamoke2. 1Ophthalmology, Medical College of Georgia -Augusta University, Augusta, GA; 2Biochemistry and Molecular Biology, Medical College of georgia-Augusta University, Augusta, GA 3224 — C0024 Blockade of NOX2 or arginase prevents diabetes-induced retinal endothelial cell senescence by restoring NO bioavailability. Modesto Rojas1, 2, T. Lemtalsi1, 2, H. A. Toque3, Z. Xu1, 2, E. Shosha1, 2, D. Fulton1, R. Caldwell3, R. B. Caldwell1, 2. 1Vascular Biology Center, Augusta University, Augusta, GA; 2Research, Veterans Affairs Medical Center, Augusta, GA; 3 Pharmacology and Toxicology, Augusta University, Augusta, GA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 225 Tuesday Posters 8:30 am – 10:15 am 3206 — C0006 Aerobic exercise protects retinal function in type 2 diabetic mice. Mamoru Kamoshita, H. Osada, E. Toda, K. Sano, M. Kawashima, N. Nagai, H. Shinoda, K. Tsubota, Y. Ozawa. Ophthalmology, Keio University School of Medicine, Shinjuku, Japan 3212 — C0012 Epac1 is required for BetaAdrenergic Receptor Regulation of VEGF in Retinal Endothelial Cells Grown in High Glucose. Youde Jiang, J. J. Steinle. Wayne State University, Detroit, MI 3217 — C0017 Barrier function studies of VEGF and ANG-2 in human endothelial cells. Guido Hartmann. Roche Innovation Center Basel, Hoffman La Roche, Basel, Switzerland *CR 3225 – 3242 – Tuesday – Posters 3225 — C0025 Loss of thioredoxin reductase-1 in the hyperglycemic milieu stimulates retinal vessel senescence and senescence-associated proinflammatory phenotype. Menaka Thounaojam1, F. Lamoke2, D. Gutsaeva1, W. Jahng3, P. M. Martin2, M. Bartoli1. 1Opthalmology, Georgia Regents University, Augusta, GA; 2Biochemistry and Molecular Biology, Georgia Regents University, Augusta, GA; 3Organic Chemistry, Biochemistry, American University of Nigeria, Yola, Nigeria 3226 — C0026 Regulation of retinal blood barrier by TNF alpha convertase, ADAM17, and its implication in diabetic macular edema. Diana Gutsaeva1, K. Hussein1, F. Lamoke1, H. Kwok2, A. Solomon3, P. M. Martin1, M. A. Al-Shabrawey1, M. Bartoli1. 1Georgia Regents University, AUGUSTA, GA; 2University of Macau, Macau, Macao; 3 Allosterix-Pharma, Moshav-Shilat, Israel *CR Tuesday Posters 8:30 am – 10:15 am 3227 — C0027 Pharmacological inhibition of STAT3 suppresses pathologic retinal neovascular growth in the mouse model of oxygeninduced retinopathy. Jose R. Hombrebueno, A. Lynch, G. Obasanmi, M. Chen, H. Xu. Centre for Experimental Medicine, Queen’s University Belfast, Belfast, United Kingdom 3228 — C0028 Effects of erythropoietin on glucose induced exacerbation of hypoxic damage in cultured photoreceptor-like cells. Christopher J. Layton1, 2, C. S. Kawai1, G. de Moraes3, K. Jenkins1, A. Y. Goh1. 1School of Medicine, University of Queensland, Brisbane, QLD, Australia; 2Ophthalmology Research Unit, Gallipoli Medical Research Institute, Brisbane, QLD, Australia; 3Faculdade de Medicina de Marília, Marila, Brazil 3229 — C0029 Tip/Stalk cell behaviour in endothelial HUVEC monolayers. Elmira Jalilian1, M. Fruttiger1, P. Coffey2. 1Cell biology, UCL institute of Ophthalmology, London, United Kingdom; 2Ocular Biology & Therapeutics, UCL Institute of Ophthalmology, London, United Kingdom *CR 3230 — C0030 Exosomes Released From Human Retinal Endothelial Cells Upon 15HETE Treatment or ER Stress Induction: Potential Role of Nanoparticles in Diabetic Retinopathy. Khaled Elmasry1, 2, K. Hussein3, 4, H. M. Saleh3, 6, A. S. Ibrahim3, 5, N. M. El-Sherbiny3, 5, I. Helwa1, Y. Liu1, 6, M. A. Al-Shabrawey3, 6. 1Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA; 2 Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Oral Biology, Dental college of Georgia at Augusta University, Augusta, GA; 4Surgery and Medicine, Oral and Dental Research Division, National Research Center, Cairo, Egypt; 5Clinical Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; 6Culver Vision Discovery Institute and Ophthalmology, Augusta, GA 3231 — C0031 Intermittent fasting prevents diabetic retinopathy by correcting the circadian clock and affecting monocyte infiltration and inflammation in the retina. Eleni Beli1, Y. Yan2, L. Moldovan1, T. Salazar1, Y. Duan3, P. Hu1, E. Hutchinson1, S. Hindi5, J. V. Busik4, M. B. Grant1. 1 Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2MD Anderson Cancer Center, University of Texas, Houston, TX;3Physiology, Indiana University School of Medicine, Indianapolis, IN; 4Physiology, Michigan State University, East Lansing, MI; 5Chemistry, IUPUI, Indianapolis, IN 3232 — C0032 Neuroprotective role of GDNF and BDNF in diabetic retinopathy. Yun-Zheng Le, M. L. Zhu. Medicine, Cell Biology, and Ophthalmology, and Harold Hamm Oklahoma Diabetes Center, Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, OK 3238 — C0038 Microscopic study of surgically excised vitreoretinal membranes. Rino Frisina1, E. Zampedri2, E. zampedri1, F. Tessarolo1, F. Piccoli3, E. Bonomi4, P. Caciagli3, G. Nollo4, F. Romanelli1.1Multizonal Unit of Ophthalmology of Autonomous Province of Trento, Rovereto, Trento, Italy; 2Depatment of Neurological and Movement Sciences, AOUI Verona, University of Verona Eye Clinic, Verona, Italy; 3Department of Laboratory Medicine, Azienda Provinciale per i Servizi Sanitari, Trento, largo Medaglie d’oro 9, Trento, Italy, Italy; 4Healthcare Research and Innovation Program (IRCS-PAT), Bruno Kessler Foundation, Trento, Italy Exhibit/Poster Hall C0039-C0086a Tuesday, May 03, 2016 8:30 AM-10:15 AM Retina 3233 — C0033 Integrin Expression in Cultured Retinal Endothelial Cells and Retinal Pericytes. Andrew T. Tsin, R. Moritz, S. Vellanki, R. LeBaron. Biology, University of Texas San Antonio, San Antonio, TX 322 Diabetic retinopathy and steroids 3234 — C0034 Regulatory mechanisms of the neuroprotective function of αA- and αBcrystallins in retinal neurons and glia. Anne Ruebsam, M. Losiewicz, J. Jiang, P. E. Fort. Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI 3239 — C0039 The presence of diabetic macular edema in patients with new onset vitreous hemorrhage associated with proliferative diabetic retinopathy. J. Brown1, 2, J. Brown1, 2, Jeremiah Brown1, 2.1Retina, Brown Retina Institute, San Antonio, TX; 2Ophthalmology, University of Texas Health Science Center, San Antonio, San Antonio, TX *CR 3235 — C0035 Systematic Analysis of the Effects of Diabetes-Relevant Stimuli on Endothelial Expression of Extracellular Matrix Constituents. Meredith J. Giblin, J. S. Penn. Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, TN *CR 3236 — C0036 Muller cells treated with alpha 1 antitrypsin (AAT) in vitro showed less expression of VEGF and IL6. Gustavo Ortiz, J. E. Gallo. Ophthalmology, Universidad Austral, Pilar, Argentina 3237 — C0037 Diverse Actions of Interleukin-6 on Human Müller Versus Human Retinal Endothelial Cells Under Hyperglycemic Conditions. Brandon Coughlin, D. J. Feenstra, S. Mohr. Department of Physiology, Michigan State University, East Lansing, MI Moderators: James C. Folk, Young Hee Yoon and Baruch D. Kuppermann 3240 — C0040 Short Term Results of Fluocinolone Acetonide Intravitreal Implant (Iluvien®) for Diabetic Macular Edema in Highly Treated Eyes. Nisha Dhawlikar1, S. P. Shah1, 2, D. L. Yarian1, 2, J. L. Prenner1, 2, E. S. Friedman1, 2, H. F. Fine1, 2, H. M. Wheatley1, 2, D. B. Roth1, 2. 1 Rutgers - Robert Wood Johnson Medical School, New Brunswick, NJ; 2NJ Retina, New Brunswick, NJ *CR 3241 — C0041 Statistical modeling to predict initial treatment response to Ozurdex for diabetic macular edema. Karishma Habbu1, 2, R. Singh1, S. Srivastava1, F. Silva1, P. K. Kaiser1, A. Babiuch1, C. Al-Dhubaib3. 1Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 2Case Western Reserve School of Medicine, Cleveland, OH; 3 Triple Analytics, Cleveland, OH *CR 3242 — C0042 Retinal inter vascular arcade area and susceptibility to diabetic maculopathy. Randev Mendis1, R. Chakrabarti2, Q. Findlay3. 1 Canberra Retina Clinic, Canberra, ACT, Australia; 2 Victoria Eye and Ear Hospital, Melbourne, VIC, Australia; 3The Canberra Hospital, Canberra, ACT, Australia The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 226 Tuesday – Posters – 3243 – 3262 3243 — C0043 Integrity of Outer Retinal Layers After Resolution of Central Involved Diabetic Macular Edema. Ilkay Kilic Muftuoglu2, 1, N. Mendoza2, R. Gaber2, M. Ragheb2, Q. You2, W. R. Freeman2. 1Ophthalmology, Istanbul Training And Research Hospital, Istanbul, Turkey; 2 Ophthalmology, University Of California San Diego, San Deigo, CA 3244 — C0044 Prospective study to evaluate the safety of Dexamethasone Intravitreal Implant in Diabetic Macular Edema. Silvio Di Monaco, S. Berteramo, N. Delle Noci, C. Iaculli. Department Of Ophthalmology, Institute Of Ophthalmology-Policlinico Di Foggia-Italy, Foggia, Italy 3245 — C0045 Role of Soluble Vascular Endothelial Growth Factor Receptor Signaling and Other Factors or Cytokines in Diabetic Macular Edema. Hidetaka Noma, K. Yasuda, M. Shimura. Ophthalmology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan 3247 — C0047 Subthreshold laser grid photocoagulation for the treatment of diabetic macular edema. Pietro Frascio, R. Rosa, D. Musetti, M. Musolino, C. Cutolo, C. E. Traverso, M. Nicolo. Clinica Oculistica Genova, Genova, Italy 3248 — C0048 Ocular photostimulation with the 577 nm micropulse yellow laser in the management of clinically significant diabetic macular edema (CSDME) - 2nd Year of Followup. Ezio Cappello1, E. Cecchin1, A. Toso1, S. Morselli1, G. Dorin2. 1Ophthalmology, Ospedale San Bassiano - Bassano del Grappa, Bassano del Grappa, Italy; 2Eyengineering Inc., Ojai, CA *CR 3249 — C0049 Reduced efficacy of intravitreal dexamethasone implant in diabetic macular edema with subfoveal cystoid spaces. Hae Jung Sun, S. Lee. Ophthalmology, Soonchunhyang University Hospital, Seoul, Korea (the Republic of) 3250 — C0050 Potential Beneficial Effect of Low Dose Danazol in Combination With Renin Angiotensin System Inhibitors in Diabetic Macular Edema: a 12-week Double Blind Randomized Controlled Trial. Michael Singer1, A. Orlando2, 3, V. Clift4, D. Bar-Or4, 2. 1 Med Ctr Ophthalmology Assoc, San Antonio, NY; 2Trauma Research, Swedish Medical Center, Englewood, CO; 3Trauma Research, St. Anthony Hospital, Lakewood, CO; 4Ampio Pharmaceuticals, Englewood, CO *CR, f 3252 — C0052 Hyperreflective Retinal Spots in Diabetic Eyes with and without Diabetic Macular Edema: B-Scan and en-face Spectral Domain Optical Coherence Tomography Evaluation. Edoardo Midena1, 2, S. Bini1, T. Torresin1, F. Martini1, P. Pucci1, A. Daniele1, R. Parrozzani2, O. Kotsafti2, S. Vujosevic1. 1University of Padova, Padova, Italy; 2GB Bietti Foundation, IRCCS, Roma, Italy 3253 — C0053 Twelve-month treatment with intravitreal dexamethasone implant for diabetic macular edema. Valentina Sarao1, 2, D. Veritti1, 2, P. Lanzetta1, 2. 1Medical and Biological Sciences Ophthalmology, University of Udine, Udine, Italy; 2 Istituto Europeo di Microchirurgia Oculare-IEMO, Udine, Italy *CR 3254 — C0054 Macular volume is better than central foveal thickness measured by SD-OCT for the detection of moderate and severe macular edema. David Rivera1, 2, A. Jimenez-Corona1, L. Perez-Peralta1, 2, S. Cardenas-Gonzalez1, E. O. Graue-Hernandez1. 1Medicine, Institute of Ophthalmology Fundación Conde De Valenciana, Mexico City, Mexico; 2Centro de Atención Integral del Paciente con Diabetes, Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico 3255 — C0055 Dexamethasone implant with fixed or individualized regimen in the treatment of diabetic macular edema: the UDBASA study. Paolo Lanzetta4, 1, D. Veritti4, 1, V. Sarao4, 1, E. Giancipoli2, F. Boscia2, C. Furino3, G. Alessio3. 1 Istituto Europeo di Microchirurgia Oculare-IEMO, Udine, Italy; 2Department of Ophthalmology, University of Sassari, Sassari, Italy; 3Department of Basic Medical Sciences, Neuroscience, and Sense Organs, University of Bari-Policlinico, Bari, Italy; 4 Department of Medical and Biological Sciences Ophthalmology, University of Udine, Udine, Italy *CR, f 3256 — C0056 Safety and Efficacy of Intravitreal Ocriplasmin in Diabetic Macular Edema with Vitreomacular Adhesion. Bernardete Pessoa1, J. Coelho1, 2, S. Monteiro1, N. Ferreira1, J. Melo Beirão1, 3, A. Meireles1, 3. 1Ophtalmology, Centro Hospitalar do Porto, Porto, Portugal; 2 Physiology and Cardiothoracic surgery, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; 3Neuroscience, Instituto de Ciências Biomédicas Abel Salazar, Porto, Portugal *CR 3257 — C0057 Preliminary results from the RESPOND trial: Investigator-driven study in Portugal to evaluate real-life safety and efficacy of ILUVIEN in patients with chronic DME. Joao Figueira1, 2, M. Amaro3, J. Henriques4, V. Rosas5. 1 CEC, AIBILI, Coimbra, Portugal; 2Ophthalmology Department, Coimbra University Hospital, Coimbra, Portugal; 3Ophthalmology Department, Hospital Vila Franca de Xira, Vila Franca de Xira, Portugal; 4Instituto de Retina e Diabetes Ocular de Lisboa, Lisboa, Portugal; 5Ophthalmology Department, Centro Hospitalar de São João, Porto, Portugal *CR, f 3258 — C0058 Clinical effectiveness of the fluocinolone acetonide implant in diabetic macular oedema resistant to anti-VEGF therapy. Spyridon E. Chalkiadakis1, 2, F. J. Harris1, 2, S. Taylor1, 2.1Ophthalmology, University Of Surrey, Guildford, United Kingdom; 2Ophthalmology, Royal Surrey County Hospital, Guilford, United Kingdom 3259 — C0059 Real-World Assessment of Dexamethasone Intravitreal Implant in Diabetic Macular Edema: Interim Analysis from the REINFORCE Study. Howard F. Fine1, M. Singer2, P. U. Dugel3, A. Capone, Jr.4, J. Maltman5. 1Rutgers UMDNJ Dept Ophthalmology, NJ Retina, New Brunswick, NJ; 2University of Texas Health Science Center, San Antonio, TX; 3Retinal Consultants of Arizona, Phoenix, AZ; 4Associated Retinal Consultants, Royal Oak, MI; 5Allergan plc, Irvine, CA *CR, f 3260 — C0060 Oral kalliginogenase improved chorioretinal blood flow levels and significantly reduced subfoveal choroidal thickness in diabetic macular edema patients. Eiko Tsuiki1, K. Suzuma1, 2, Y. H. Mohamed1, Y. Yamada1, M. Matsumoto1, T. Kitaoka1. 1Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; 2 Ophthalmology and Visual Sciences, Kyoto University, Kyoto, Japan f 3261 — C0061 Variations Of The Diabetic Macular Edema After Cataract Surgery On Patients Being Treated With NSAIDs And/Or Resveratrol Supplements. Luigi Zompatori, E. Sterbini, R. Salvati, S. Altimari. Tivoli Hospital, Tivoli, Italy 3262 — C0062 Variations in the size of retinal cysts as a tomographic factor predictor for retreatment with Ozurdex in patients with refractory diabetic macular edema. Félix Alexander Manco Lavado1, 2, M. Ramoa Osorio1, 2, M. Lopez1, 2, L. Manzanas Leal1, 2, I. Alonso de la Fuente1, 2, M. Hernando Verdugo3. 1Ophthalmology, Hospital Clinico Universitario, Valladolid, Spain; 2 Ophthalmology, IOBA (University of Valladolid), Valladolid, Spain; 3Pharmacy, Hospital Clinico Universitario, Valladolid, Spain f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 227 Tuesday Posters 8:30 am – 10:15 am 3246 — C0046 Indocyanine green-guided targeted photocoagulation of macroaneurysms in macular edema: a pilot study. Benedicte M. Dupas1, E. Philippakis1, S. meimon2, C. Bonnet3, J. GIRMENS3, M. Paques3. 1Hospital Lariboisiere, Paris, France; 2Office National d’Etudes et de Recherches Aéronautiques, Département d’Optique Théorique et Appliquée (ONERA-DOTA, Chatillon, France; 3Clinical Investigation Center 1423, Quinze-Vingts Hospital, INSERM & Université Pierre et Marie Curie-Paris, Paris, France 3251 — C0051 Identification of AntiHexokinase-1 Antibody in the Sera from Patients with Diabetic Macular Edema. Tatsuya Yoshitake, T. Murakami, K. Suzuma, S. Yoshitake, A. Uji, M. Fujimoto, Y. Miwa, N. Yoshimura. Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan *CR 3263 – 3284 – Tuesday – Posters 3263 — C0063 Efficacy and safety of dexamethasone intravitreal implant for diabetic macula edema in clinical practice: real-world results. Brian Savoie, J. Jonisch. Ophthalmology, North Shore Long Island Jewish Health System, Bellerose, NY 3264 — C0064 Visit Adherence in Diabetic Macular Edema Patients. Neepa Shah, L. Kanu, N. Fuerst, M. Lau, D. Dao, E. Atkinson, B. L. VanderBeek. Ophthalmology, University of Pennsylvania, Philadelphia, PA Tuesday Posters 8:30 am – 10:15 am 3265 — C0065 Early effects of intravitreal steroid on severe diabetic macular edema: morphological and functional features. Simona Maria Caprani1, S. Donati1, J. Cattaneo1, M. Mazzola1, L. Premoli1, M. Bianchi1, Z. Stefano1, M. Romano2, S. Gandolfi3, F. Semeraro4, C. Azzolini1. 1 Department of Surgical and Morphological Sciences - Section of Ophthalmology, University of Insubria, Varese, Italy; 2Ophthalmology Clinic, University of Napoli, Napoli, Italy; 3Ophthalmology Clinic, University of Parma, Parma, Italy; 4 Ophthalmology Clinic, University of Brescia, Brescia, Italy 3270 — C0070 Novel Serum Cytokines and Chemokines in Diabetic Macular Edema. Finny Monickaraj1, C. Franco Nitta1, 2, P. McGuire3, A. Das1, 2. 1Surgery/Ophthalmology, University of New Mexico School of Medicine, Albuquerque, NM; 2New Mexico VA Health Care System, Albuquerque, NM; 3Cell Biology & Physiology, University of New Mexico School of Medicine, Albuquerque, NM 3277 — C0077 Does the Vitreous Protect the Retina, Vasculature, and Optic Nerve from Impact During Intravitreal Injection of Dexamethasone Implants? Stavros N. Moysidis1, N. Koulisis1, L. C. Olmos1, A. A. Moshfeghi1, N. A. Rao1, M. S. Humayun1, 2, D. C. Rodger1. 1USC Eye Institute, University of Southern California, Los Angeles, CA; 2USC Institute for Biomedical Therapeutics, Los Angeles, CA *CR 3271 — C0071 Quantitative evaluation of hard exudates in diabetic macular edema after intravitreal injection of steroid and anti-vascular endothelial growth factor. Yong Un Shin, H. Cho, H. Lim, S. Park, E. Hong. Ophthalmology, Hanyang University Guri Hospital, Gyeonggi-do, Korea (the Republic of) 3278 — C0078 Precision Size and Shape Extended Release Intravitreal Dexamethasone Implants. Sanjib K. Das, S. Williams, J. Tully, R. S. Verhoeven, M. Yang, T. Navratil, R. Schiffman. Implantable implant Research, Envisia Therapeutics, Morrisville, NC 3272 — C0072 The outcome of chronic diabetic macular oedema in patients treated with intravitreal Fluocinolone acetonide (Iluvien). Ibraheem El-Ghrably. Ophthalmology, James Cook University Hospital, Newcastle Upon-Tyne, United Kingdom *CR 3266 — C0066 Role of Vascular Changes in Diabetic Cystoid Macular Edema: An Optical Cohorens Tomography (OCT)-based study. Ata Baytaroğlu1, A. Agin1, Y. Çevik2, U. Acar1, G. Sobaci1.1Ophthalmology, Hacettepe University, Ankara, Turkey; 2Ophthalmology, Ardahan State Hospital, Ardahan, Turkey 3273 — C0073 A retrospective evaluation of the efficacy and safety of fluocinolone acetonide 0.2 μg implant in patients with chronic diabetic macular edema with insufficient response to other therapies.Angelina Meireles1, 2, J. Coelho1, B. Pessoa1. 1Ophthalmology, Centro Hospitalar do Porto - HSA, Porto, Portugal; 2Medicine Faculty, Abel Salazar Biomedical Sciences Institute, Porto, Portugal 3267 — C0067 Pro-permeability Factors in Diabetic Macular Edema; the Diabetic Macular Edema Treated with Ozurdex (DMEO) Trial. Tahreem A. Mir, A. Scott, L. He, R. Channa, C. Mayerle, J. T. Handa, S. A. Kherani, Y. S. Han, G. Wang, J. Qian, P. A. Campochiaro. The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD *CR, f 3274 — C0074 Dexamethasone implant in diabetic macular edema patients with high visual acuity. Riccardo Sacconi1, M. Battaglia Parodi2, S. Casati1, R. Lattanzio2, F. Bandello2, G. Marchini1.1Ophthalmology Unit, University of Verona, AOUI, Verona, Italy; 2Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy *CR 3268 — C0068 Repeatability and reproducibility of retinal and choroidal thickness measurements in Diabetic Macular Edema using Swept-source Optical Coherence Tomography. Anna Sala-Puigdollers, J. Zarranz-Ventura, M. Figueras-Roca, M. Hereu, T. Hernandez, M. Morató, M. Mesquida, V. Llorens, M. Sainz de la Maza, A. Adan Civera. Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona, Spain 3275 — C0075 Qualitative and quantitative analysis of retinal vascular impairment in Diabetic Maculopathy: an OCT-Angiography assessment. Gabriel J. Coscas2, 1, M. Lupidi3, 2, F. Tito3, C. Cagini3, F. Coscas2, 1. 1Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France; 2Centre Ophtalmologique De L’Odeon, Paris, France; 3Department of Biochemical and Surgical Sciences, Section of Ophthalmology, University of Perugia, Perugia, Italy 3269 — C0069 Trends in diabetic macular edema therapy at a single academic institution. Levi N. Kanu1, N. Shah1, N. Fuerst1, M. Lau1, E. Atkinson1, D. Dao1, B. L. VanderBeek1, 2. 1Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 3276 — C0076 Modifications of Retinal Inflammatory Biomarkers after Intravitreal Steroid and anti-VEGF Treatment in Diabetic Macular Edema. Stela Vujosevic1, T. Torresin1, S. Bini1, M. Berton1, F. Martini1, P. Pucci1, A. Daniele1, E. Midena1, 2. 1Ophthalmology, University of Padova, Padova, Italy; 2G.B. Bietti Foundation, IRCCS, Rome, Italy 3279 — C0079 Early intravitreal triamcinolone acetonide for persistent diabetic macular edema after vitrectomy. Masahiko Sugimoto, M. Kondo, A. Ichio. Ophthalmology, Mie University School of Medicine, Tsu, Japan f 3280 — C0080 Diabetic macular edema treatment management by french retinal specialists. Lise Qu1, F. Fajnkuchen1, 2, G. Chaine1, A. Giocanti1. 1CHU d’Avicenne, Paris, France; 2 Centre Ophtalmologique d’Imagerie et de Laser, France, Paris, France *CR 3281 — C0081 Clinical management of diabetic macular edema by retina specialists in clinical practice in Spain: OBSERVAR Study. Beatriz Romero1, A. Pareja3, M. Abraldes2, M. Roura1. 1Novartis Pharma, Barcelona, Spain; 2 Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain; 3 Hospital Universitario de Canarias, Tenerife, Spain *CR 3282 — C0082 Change in retinal function and morphology in patients with Diabetic macular edema switching from anti-VEGF to steroid (Fluocinolone acetonide). Radha Das, U. Chakravarthy. School of Medicine, Queens University, Belfast, BELFAST, United Kingdom *CR 3283 — C0083 Sustained Intraocular Delivery of Fluocinolone Acetonide Slows Progression of Diabetic Retinopathy. Peter A. Campochiaro1, C. C. Wykoff2, B. Kapik3, K. E. Green3. 1Surgery, Johns Hopkins Wilmer Eye Inst, Baltimore, MD; 2Retina Consultants of Houston, Houston, TX; 3Alimera Sciences, Inc., Alpharetta, GA *CR, f 3284 — C0084 Incidence and risk factor of elevated intraocular pressure after dexamethasone intravitreal implant. Jiwoong Lee, H. Lim. Ophthalmology, Pusan National University, Busan, Korea (the Republic of) The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 228 Tuesday – Posters – 3285 – 3303 3285 — C0085 Ocular Safety of Intravitreal Anti Connective Tissue Growth Factor Neutralizing Antibody. Narsis Daftarian1, 2, T. Motevasseli1, A. Bagheri2, 3, M. Rezaeikanavi2, H. Ahmadieh1, 2, Z. Soheili4. 1Ophthalmology, Ophthalmic Research Center, SBMU, Tehran, Iran (the Islamic Republic of); 2Ophthalmology, Ocular Tissue Engineering Research Center, SBMU, Tehran, Iran (the Islamic Republic of); 3Genetics, 3-University of Social Welfare and Rehabilitation Sciences, Tehran, Iran (the Islamic Republic of); 4Genetics, 4- National Institute of Genetic Engineering and Biotechnology, Tehran, Iran (the Islamic Republic of) 3286 — C0086 Substained intraocular hypertension or steroids-induced Glaucoma after dexamethasone implant (DEX implant) intravitreal injection, myth or reality? Amina Rezkallah1, L. Kodjikian1, A. Macles2, H. El Chehab2, A. Vie1, E. Agard2, A. NGuyen1, C. Dot2. 1 Hôpital de la Croix Rousse, Lyon, France; 2Hôpital d’instruction des armées Desgenettes, Lyon, France Exhibit/Poster Hall D0029-D0062 Tuesday, May 03, 2016 8:30 AM-10:15 AM Immunology/Microbiology / Glaucoma 323 Inflammation / Infection/ Imaging / Non infectious Uveitis Moderators: Philip I. Murray and Richard W. Lee 3287 — D0029 Diagnostic evaluation of RTVue-100 fourier-domain corneal anterior module OCT system in uveitic eyes of various etiologies. Noriyasu Hashida, S. Koh, T. Soma, Y. Oie, N. Maeda, K. Nishida. Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan f 3288 — D0030 A comparison of ocular syphilis phenotypes between HIV-Infected and nonHIV adult patients. Yan Yee Hah1, S. Yap1, S. Ho1, S. Teoh1, 2, R. V. Agrawal1. 1Ophthalmology Department, Tan Tock Seng Hospital, Singapore, Singapore; 2Eagle Eye Centre, Singapore, Singapore *CR 3289 — D0031 Prophylactic and therapeutic effects of oral administration of transgenic rice on birch pollen-induced allergic conjunctivitis in mice. Waka Ishida1, K. Fukuda1, L. Yang2, F. Takaiwa2, A. Fukushima1. 1Ophthalmology, Kochi Medical School, Nankoku, Japan; 2Functional Transgenic Crop Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Japan 3291 — D0033 Second harmonic generation imaging of corneal stroma after infection by Pseudomonas aeruginosa. Danielle M. Robertson, M. Petroll. Ophthalmology, Univ Texas Southwestern Medical Ctr, Dallas, TX 3292 — D0034 Clinical features and Seasonal Variation of HLA B27 positive associated anterior uveitis in an Argentine Tertiary University Hospital. Mariana Ingolotti1, M. S. Ormaechea1, J. Fernandez1, M. Portela1, A. Lupinacci1, C. A. Couto2, M. J. Saravia1, B. A. Schlaen1. 1Hospital Universitario Austral, Pilar, Argentina; 2Hospital de Clinicas, Capital Federal, Argentina 3293 — D0035 The Herpes Simplex Virus LAT Gene is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits. Lbachir BenMohamed, A. Khan, R. Srivastava, S. Wechsler, A. B. Nesburn. Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 3294 — D0036 Beta-glucan modulates Th2 immune response by inducing IL-10+ CD4 T cells in allergic conjunctivitis. Hyun Soo Lee1, J. Kwon1, C. Rho2, C. Joo1. 1Seoul St.Mary Hospital, Seoul, Korea (the Republic of); 2Ophthalmology, Daejeon St. Mary’s Hospital, Daejeon, Korea (the Republic of) 3295 — D0037 Serum lipopolysaccharide levels are associated with disease activity of the oral mucous membrane in Behçet’s Disease. L. Low1, Liying Low1, L. Morton1, G. R. Wallace1, D. Situnayake2, S. Rauz1, P. I. Murray1. 1Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; 2Rheumatology Department, Behçet’s Syndrome National Centre of Excellence, Birmingham, United Kingdom 3296 — D0038 Variable clinical course of cytomegalovirus anterior uveitis in Japanese patients. Yosuke Harada, K. Fukuda, A. Nakahira, K. Tada, T. Sumi, A. Fukushima. Development Dept., Kochi Medical School, Nankoku, Japan 3297 — D0039 Involvement of NETosis in LPS-induced ocular inflammation in a mouse model. Tilda Barliya1, 2, D. Rima3, Y. Nisgav1, 2, M. Dachbash1, 2, D. Gaton1, 4, G. Kenet3, 4, D. Weinberger1, 4, T. Livnat2, 3. 1Rabin Medical Center, Petach Tikva, Israel; 2Felsenstein Medical Research Center (FMRC), Petach Tikva, Israel; 3The Israeli National Hemophilia Center, Sheba Medical Cener, Ramat Gan, Israel; 4Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel 3298 — D0040 Naïve retina-specific T cells provide neuroprotection to retinal ganglion cells in mouse models of glaucoma. Jennifer L. Kielczewski1, R. Horai2, R. R. Caspi2. 1Laboratory of Immunology & Imaging Core, NEI/NIH, Bethesda, MD; 2Laboratory of Immunology, NEI/NIH, Bethesda, MD 3299 — D0041 The rd8 mutation in the Crumbs1 gene upregulates activation markers on retinal and brain microglia and CD11c-eYFP+ cells. Samantha Dando1, C. Naranjo-Golborne1, H. Chinnery2, M. Ruitenberg3, P. G. McMenamin1. 1 Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia; 2Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia; 3School of Biomedical Sciences, University of Queensland, St Lucia, QLD, Australia 3300 — D0042 A monoclonal antibody targeting the HSV-1/2 glycoprotein B inhibits the development herpes simplex virus type 1 retinitis in mice. Dirk Bauer1, M. Alt2, M. Dirks2, M. Kasper1, A. Buch3, U. Dittmer2, A. Goergens4, B. Sodeik3, A. Heiligenhaus1, R. Michael2, A. Krawczyk2. 1Ophtha-Lab, Department of Ophthalmology at St. Franziskus Hospital, Munster, Germany; 2Institute of Virology, University Hospital Essen, Essen, Germany; 3Department of Virology, Hannover Medical School, Hannover, Germany; 4 Department for Transfusion Medicine, University Hospital Essen, Essen, Germany *CR 3301 — D0043 Ocular Manifestations In Dengue Fever. Anne-Laure Remond, N. Butel, C. Fardeau, M. Errera, P. LeHoang, B. Bodaghi. Department of Ophthalmology, Pitie-Salpetriere, Paris, France 3302 — D0044 Th17-associated cytokines in aqueous humor of acute primary angle-closure eyes. Shida Chen, Y. liu, X. li, X. Zhang. zhongshan ophthalmic center, Guangzhou, China 3303 — D0045 The relationship between quantitative pupillometry and estimated ganglion cell counts in patients with glaucoma. Dolly S. Chang, M. V. Boland, K. Arora, D. S. Friedman. Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 229 Tuesday Posters 8:30 am – 10:15 am 3286a — C0086a Novel biomarkers of diabetic retinopathy based on dynamic fluorescein enhanced fluorescent imaging. Jennifer J. KangMieler, E. Dosmar, W. Liu, S. Hu, K. M. Tichauer. Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 3290 — D0032 Inhibition of Fibrin and Inflammation with Enoxaparin and Triamcinolone in a Juvenile Rabbit Model of Lensectomy. Jonathon Young1, D. Conklyn2, J. Bogaard3, H. Whiteley4, I. S. Kassem2, 1. 1Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI; 2Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 3Ophthalmology, University of Illinois at Chicago, Chicago, IL; 4Veterinary Medicine, University of Illinois at UrbanaChampaign, Champaign, IL *CR Tuesday Posters 8:30 am – 10:15 am 3304 – 3324 – Tuesday – Posters 3304 — D0046 Aqueous humour cytokines in Fuchs uveitis syndrome patients with or without secondary glaucoma. Carsten Heinz1, 2, M. Kasper1, O. Tektas3, D. Bauer1, K. Walscheid1, J. Koch1, P. Muether4, A. Heiligenhaus1, 2. 1 Ophthalmology, St. Franziskus Hospital, Muenster, Germany; 2Ophthalmology, University Duisburg-Essen, Essen, Germany; 3Anatomy, University Nuremberg-Erlangen, Erlangen, Germany;4Ophthalmology, University Koeln, Koeln, Germany 3310 — D0052 Variability in full-field electoretinogram measurements in patients with birdshot chorioretinopathy. Jared E. Knickelbein, M. Wei, B. G. Jeffrey, R. B. Nussenblatt, H. Sen. National Eye Institute, Bethesda, MD 3305 — D0047 Validation study for an imagebased standardized grading system for scleritis. Maggie M. Wei, J. E. Knickelbein, K. R. Armbrust, D. Cunningham, S. Vitale, R. B. Nussenblatt, H. Sen. Department of Ophthalmology, National Institute of Health, Bethesda, MD 3312 — D0054 Visual Acuity and Inflammation Outcomes in Intermediate Uveitis. Elliot Crane1, M. Shum1, J. S. Kim1, E. Kim1, A. B. Crane1, D. S. Chu1, 2. 1Rutgers New Jersey Medical School, Pine Brook, NJ; 2Metropolitan Eye Research and Surgery Institute, Palisades Park, NJ 3306 — D0048 Establishment and characterization of hIRBP-induced experimental autoimmune uveoretinitis in mice. Jian Li1, J. Ren2, W. Yip1, X. Zhang1, S. Chan2, W. Chu1, C. C. Pang1. 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China 3313 — D0055 TIGIT+ Tregs May Be Associated with Clinical Remission of NonInfectious Uveitis. Rose Gilbert1, 2, X. Zhang1, R. Sampson1, O. Tomkins-Netzer2, 1, G. Galatowicz1, V. L. Calder1, S. Lightman2, 1. 1UCL Institute of Ophthalmology, London, United Kingdom; 2 Moorfields Eye Hospital, London, United Kingdom 3307 — D0049 Differentiating Endophthalmitis from Uveitis and Vitreoretinal Lymphoma by Aqueous and Vitreous IL-6 and IL-10. David Kuo, M. M. Wei, K. R. Armbrust, I. Yeung, C. Chan, R. B. Nussenblatt, H. Sen. National Eye Institute, National Institutes of Health, Bethesda, MD 3308 — D0050 Adalimumab in patients with active and inactive, non-infectious uveitis: VISUAL I and VISUAL II trials. Antoine P. Brezin1, A. D. Dick2, 3, G. J. Jaffe4, S. Ohno5, K. Namba5, H. Goto6, N. Inomata7, A. P. Song8, M. Kron9, A. Camez9, Q. Nguyen10. 1INRA, CNRS, University of Burgundy, Hopital Cochin-Univ Paris Descartes, Paris, France; 2University of Bristol, Bristol Eye Hospital, Bristol, United Kingdom;3National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London, Institute of Ophthalmology, London, United Kingdom; 4Duke University, Durham, NC;5Hokkaido University Graduate School of Medicine, Sapporo, Japan; 6Tokyo Medical University, Tokyo, Japan; 7AbbVie GK Japan, Tokyo, Japan; 8AbbVie Inc., North Chicago, IL; 9AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany; 10Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE *CR, f 3309 — D0051 The effect of topical difluprednate on vascular leakage in noninfectious uveitis. Daniel Feiler, C. Y. Lowder, K. Baynes, S. K. Srivastava. Ophthalmology, Cleveland Clinic Cole Eye Institute, Cleveland, OH *CR 3311 — D0053 Literature Review: Comorbidities and Complications with Intermediate Uveitis. Eliott Kim, E. Crane, J. S. Kim, M. Shum, D. S. Chu. Rutgers University, Newark, NJ 3314 — D0056 The development of ocular complications in subjects diagnosed with intermediate uveitis. Jason S. Kim, E. Kim, E. Crane, M. Shum, D. S. Chu. Rutgers University, New York, NY 3315 — D0057 Determination of CD4/ CD8 ratio in undiluted vitreous samples provides useful information for the diagnosis of ocular sarcoidosis. Joachim Van Calster, R. Van Ginderdeuren. University Hospitals Leuven, Leuven, Belgium 3316 — D0058 Choroidal thickness is a marker for successful tapering of therapy in VKH disease. Enzo Castiglione, R. Anguita, T. Barrueto, C. Lopez, F. Rojas, R. Vidal. Departamento de Oftalmologia, Universidad de Chile, Santiago, Chile 3317 — D0059 Tubulointerstitial Nephritis and Uveitis Syndrome: Characterization of Clinical Features. Anjum F. Koreishi, R. Desai, A. Birnbaum, D. Pyatetsky, D. A. Goldstein. Ophthalmology, Northwestern University, Chicago, IL 3318 — D0060 Increased Frequency of Herpes Simplex Virus-Specific Effector Memory CD26+CD8+ T Cells in HSV-Seropositive Ocular Herpes Asymptomatic Patients. Anthony B. Nesburn, R. Srivastava, A. Khan, S. Wechsler, L. BenMohamed. Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 3319 — D0061 Exploring associations between anatomical and functional parameters in Birdshot chorioretinopathy using optical coherence tomography and electroretinography. William R. Tucker1, 2, A. E. Hobby2, 1, I. T. Hossain2, C. J. Hammond2, M. R. Stanford2, O. A. Mahroo2, 1. 1 Medical Retina, Moorfields Eye Hospital, London, United Kingdom; 2Ophthalmology, King’s College London, St Thomas’ Hospital Campus, London, United Kingdom 3320 — D0062 Computational Methods for Analyzing Patient Data. Alexander B. Crane, E. Crane, M. Shum, J. S. Kim, E. Kim, D. S. Chu. Ophthalmology, Rutgers, Pine Brook, NJ Exhibit/Poster Hall D0124-D0173 Tuesday, May 03, 2016 8:30 AM-10:15 AM Retina 324 AMD and anti-VEGF Therapy 2 Moderators: Milam A. Brantley and Jay M. Stewart 3321 — D0124 AAV2 Mediated Expression of Intraceptor Flt23k Shows No Endoplasmic Reticulum Stress Response. Austin Bohner, X. Zhang, H. Uehara, B. Archer, B. Ambati. John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 3322 — D0125 Dose-Efficacy and Safety of Targeted Intraceptor Flt23k Nanoparticle in Mice. Xiaohui Zhang, A. Bohner, S. Bondalapati, S. K. Kumar Muddana, H. Uehara, B. Archer, B. Ambati. Moran Eye Center, University of Utah, Salt Lake City, UT 3323 — D0126 Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model. Adrian WillOrrego, S. Liao, Y. Qiu, E. Fassbender, S. Shen, N. Kotagiri, B. D. Jaffee, S. H. Poor. Ophthalmology, Novartis Institutes for Biomedical Research, Cambridge, MA *CR 3324 — D0127 Retinal Toxicity of Intravitreal Injection of Ziv-Aflibercept in albino rabbits. Dan M. Ramon5, Y. Shahar2, 1, A. Massarweh3, I. Mann3, I. Perlman3, 4, A. Loewenstein1, 2. 1Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 2Department of Ophthalmology, Tel-Aviv Medical Center, Tel-Aviv, Israel; 3Department of Physiology and Biophysics, Technion-Israel Institute of Technology, Ruth & Bruce Rappaport Faculty of Medicine, Haifa, Israel; 4Rappaport Institute, Haifa, Israel; 5Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 230 Tuesday – Posters – 3325 – 3343 3325 — D0128 Ranibizumab and Bevacizumab treatment after retinal ischemia-reperfusion injury in a rodent model. Marina Renner, S. Lohmann, D. Schulte, G. Stute, H. Dick, S. Joachim. Experimental Eye Research Institute, University Eye Hospital, Bochum, Germany 3326 — D0129 Clearance of Aflibercept Following Intravitreal Injection in a Rat Model. Ruti Sella1, 2, O. Gal-Or1, A. Dotan1, M. Dachbash3, Y. Nisgav3, D. Weinberger1, 2, R. Ehrlich1, 2, T. Livnat2, 3.1Department of Ophthalmology, Rabin Medical Center, Petach-Tikva, Israel; 2Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; 3Laboratory of Eye Research, Felsentstein Medical Research Center, Rabin Medical Center, Petach-Tikva, Israel 3328 — D0131 ROS-responsive nanoparticles to extend the lifetime of anti-angiogenic drugs. Viet Anh Nguyen Huu1, J. Zhu2, J. Luo2, S. Patel2, G. Collet3, C. de Gracia Lux3, K. Zhang2, A. Almutairi3.1Nanoengineering & School of Pharmacy, University of California, San Diego, La Jolla, CA; 2School of Medicine, University of California, San Diego, La Jolla, CA; 3School of Pharmacy, University of California, San Diego, La Jolla, CA 3329 — D0132 Experimental model to characterize bubble formation in intravitreal injections. Jackson Abou Chehade, E. Elborgy, S. Alniemi, B. Nicholson, R. Iezzi. Ophthalmology, Mayo Clinic, Rochester, MN 3330 — D0133 Optimal Buffer for Storage of Ranibizumab at Low Concentrations. Hui Yee Chua1, R. V. Agrawal5, T. T. Wong4, P. Preiser3, S. Venkatraman2. 1Interdisciplinary Graduate School, Nanyang Technological University, Singapore, Singapore; 2Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore; 3Biological Sciences, Nanyang Technological University, Singapore, Singapore;4Singapore Eye Research Institute, Ocular Drug Delivery Group Singapore National Eye Centre, Singapore, Singapore; 5National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore 3332 — D0135 Factors associated with retreatment after photodynamic therapy combined with intravitreal ranibizumab for polypoidal choroidal vasculopathy. Wataru Kikushima, Y. Sakurada, A. Sugiyama, N. Tanabe, S. Yoneyama, H. Iijima. Ophthalmology, University of Yamanashi, Chuo, Japan 3333 — D0136 Real Life Setting Treatment By Anti-Vascular Endothelial Growth Factor For Wet Age-Related Macular Degeneration: Inactivation Of Lesion And Long Term Outcomes. Mohamed Maher Haouas2, 1, G. Thuret2, 3, P. GAIN2, M. Paques1, J. Sahel1, J. Girmens1. 1DHU SightRestore, Quinze-Vingts National Hospital, Paris, France;2Ophtalmology, Hospital North, Saint-Etienne, France; 3France University Institute, Paris, France *CR 3334 — D0137 Real-life outcomes of switching AntiVEGF treatment from ranibizumab to aflibercept for neovascular agerelated macular degeneration (nAMD): UK multicentre study. Faruque D. Ghanchi1, N. Patel2, J. S. Talks3, A. J. Lotery4, S. Sivaprasad7, C. Bailey5, R. Johnston6, M. McKibbin8. 1Ophthalmology, Bradford teaching Hospitals, Bradford, United Kingdom; 2East Kent University Hospitals, Canterbury, United Kingdom; 3 Newcastle Upon Tyne Hospitals Foundation NHS Trus, Newcastle upon Tyne, United Kingdom; 4 Faculty of Medicine, University of Southampton, Southampton, United Kingdom; 5Bristol Eye Hospital, Bristol, United Kingdom; 6Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom; 7Kings College Hospital, London, United Kingdom; 8St James University Hospital, Leeds, United Kingdom *CR 3335 — D0138 Real-world treatment patterns in injection cost and frequency for ranibizumab versus aflibercept in patients with wet agerelated macular degeneration: A 2-year US claims analysis. Szilard Kiss1, Y. Rajput2, C. Quezada Ruiz2, K. Wilson3, A. Huang3, D. M. Smith3, H. Varker3, S. S. Johnston3. 1Physics & Astronomy/Sch of Optometry, Weill Cornell Medical College, New York, NY; 2Genentech, Inc., South San Francisco, CA; 3Truven Health Analytics, Bethesda, MD *CR 3336 — D0139 Factors associated with poor response to aflibercept after switching from ranibizumab or bevacizumab in neovascular age-related macular degeneration (AMD). Sarah Cheng, T. Leng. Ophthalmology, Stanford University, Palo Alto, CA *CR 3337 — D0140 Safety and complications of Intravitreal injections performed over 8 years at a tertiary eye centre in Singapore. Yanping Xu, C. S. Tan. Ophthalmology, National Healthcare Group Eye Institute, Singapore, Singapore 3338 — D0141 Patient-level Meta-analysis of the Safety of Bevacizumab vs Ranibizumab in International Randomized Clinical Trials for the Treatment of Neovascular Age-Related Macular Degeneration. James A. Shaffer. Ophthalmology, University of Pennsylvania, Philadelphia, PA f 3339 — D0142 Evaluation of cytotoxicity of Pazopanib on proliferation of vascular endothelial growth factor enriched choroidal vascular endothelial cells. K. V. Chalam, B. Mynampati Arunadithya, K. Sambhav. Ophthalmology, University of Florida, Jacksonville, FL 3340 — D0143 A real-world evaluation of frequency of ranibizumab and aflibercept deliveries for treatment-naïve patients with neovascular age-related macular degeneration: 12-month results from the French LYVE survey. Oudy Semoun1, R. Blanco-Garavito1, S. Y. Cohen2, L. Finzi3, C. Maurin3, E. H. Souied1. 1Ophtalmology, Centre Hospitalier Intercommunal de Créteil, Créteil, France; 2Centre Imagerie et Laser, Paris, France; 3Retine, Novartis Pharma SAS, RueilMalmaison, France *CR 3341 — D0144 Angiogenesis Agents Levels After Bevacizumab Intravitreal Injection in Patients with Neovascular Age-related Macular Degeneration. Thiago Cabral1, 2, L. H. Lima1, J. Polido1, E. P. Correia3, P. D. Serracarbassa3, C. V. Regatieri1, B. Rubens1. 1Ophthalmology, UNIFESP, Vitoria/ES, Brazil; 2Ophthalmology, UFES, Vitória, Brazil; 3Ophthalmology, HSPE/IAMSPE, Sao Paulo, Brazil 3342 — D0145 Real-world one year outcomes of a switch to aflibercept from ranibizumab in neovascular age related macular degeneration. Maria C. Citu, R. R. Crosby-Nwaobi, M. Eleftheriadou, C. Vazquez-Alfageme, L. Nicholson, S. Sivaprasad, P. Hykin, R. D. Hamilton. NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom *CR 3343 — D0146 Real World U.S. Outcomes of Anti-Vascular Endothelial Growth Factor (VEGF)Therapy in Neovascular AMD (NAMD): Risk of Vision Loss is Greatest in Patients with Better Baseline Visual Acuity. Forbes Huang1, K. Westby1, D. F. Williams2, T. A. Ciulla1, S. Zaveri1, S. Patel1. 1Ophthotech, Princeton, NJ; 2Vestrum Health, Naperville, IL *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 231 Tuesday Posters 8:30 am – 10:15 am 3327 — D0130 What is the biologically relevant KD for VEGF binding to ranibizumab in the eye? A comparison of in-vivo and in-vitro estimates. Norman Mazer1, D. Schwab1, L. HuttonSmith2, H. M. Byrne2, E. A. Gaffney2, P. Maini2, G. Hartmann3, J. Moelleken4, C. Gassner4, J. T. Regula4. 1Clinical Pharmacology, Roche Innovation Center Basel, Basel, Switzerland; 2Wolfson Centre of Mathematical Biology, University of Oxford, Oxford, United Kingdom; 3Neuroscience Ophthalmology and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland; 4Large Molecule Research, Roche Innovation Center Penzberg, Penzberg, Germany *CR 3331 — D0134 No excuses. Bevacizumab should be first choice in AMD. Freekje Van Asten1, C. Michels2, C. C. Hoyng1, G. van der Wilt2, B. Klevering1, M. M. Rovers2, J. P. Grutters2. 1 Ophthalmology, Radboud umc, Nijmegen, Netherlands; 2Health Evidence, Radboud umc, Nijmegen, Netherlands 3344 – 3364 – Tuesday – Posters 3344 — D0147 Variation in Ophthalmologist Use of Anti-VEGF Therapy Among Medicare Beneficiaries. Rachel Thakore1, P. B. Greenberg6, 4, D. French2, 3, J. J. Behrens5. 1Warren Alpert Medical School of Brown University, Providence, RI; 2 Department of Ophthalmology and the Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL; 3Veterans Affairs Health Services Research and Development Service, Chicago, IL; 4Ophthalmology, Providence VA Medical Center, Providence, RI; 5Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL; 6 Ophthalmology, Warren Alpert Medical School of Brown University, Providence, RI 3351 — D0154 Association between prior response to ranibizumab treatment and disease quiescence: Implications for AMD dosing. Rahul N. Khurana1, L. K. Chang1, H. Shapiro2, A. Ghanekar2, S. Gune2.1Retina, Northern California Retina Vitreous Associates, Mountain View, CA, CA; 2Genentech, Inc., South San Francisco, CA *CR, f 3345 — D0148 Patient satisfaction with nurse delivered intravitreal injections. adam mapani, Y. Khan. Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom *CR 3353 — D0156 Time to recurrence in neovascular age-related macular degeneration after ranibizumab treatment: baseline characteristics of treatment-naive patients enrolled in the ORACLE study.François Devin9, E. Fourmaux1, G. quentel2, J. Uzzan3, M. Quaranta El-Maftouhi4, C. Français-Maury5, W. Roquet6, L. Castelnovo10, S. Razavi7, L. Finzi8. 1Ophtalmology, Palais Galien, Bordeaux, France;2Centre Imagerie et Laser, Paris, France; 3Ophtalmology, Clinique Mathilde, Rouen, France; 4Ophtalmology, Centre Rabelais, Lyon, France; 5Ophtalmology, Centre de l’Odéon, Paris, France; 6Ophtalmology, Centre Blatin, Clermont-Ferrand, France; 7Ophtalmology, Clinique Saint-Gatien, Tours, France; 8Retine, Novartis Pharma SAS, Rueil-Malmaison, France; 9 Ophtalmology, Centre Monticelli Paradis, Marseille, France; 10Ophtalmology, Clinique Maison Rouge, Strasbourg, France *CR Tuesday Posters 8:30 am – 10:15 am 3346 — D0149 Outcomes of an intravitreal injection clinic. Elizabeth Atchison1, S. J. Bakri1, A. F. Omar2. 1Ophthalmology, Mayo Clinic, Rochester, MN; 2Ophthalmology, UT Southwestern Medical Center, Dallas, TX *CR 3347 — D0150 Evaluation of the efficiency of intravitreal Aflibercept in patients affected with Occult Choroidal Neovascularisation (OCNV), Polypoidal Choroidal Vasculopathy (IPVC) and Retinal Angiomatous Proliferation (RAP) previously treated with intravitreal Ranibizumab. Simona Altimari, R. Salvati, L. Zompatori. San Giovanni Evangelista Hospital, Tivoli, Italy 3348 — D0151 Efficacy of aflibercept in wet age-related macular degeneration nonresponsive to ranibizumab. Darren Shu Jeng Ting, J. Suleman, P. S. Severn, S. Pushpoth. The James Cook University Hospital, Middlesbrough, United Kingdom 3349 — D0152 Prediction of low and high antiVEGF treatment requirements during the PRN phase from early OCT images in neovascular age-related macular degeneration. Hrvoje Bogunovic1, S. M. Waldstein1, A. Sadeghipour1, T. Schlegl1, B. Gerendas1, A. Osborne2, U. Schmidt-Erfurth1. 1Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Vienna Reading Center, Vienna, Austria; 2Genentech, Inc, South San Francisco, CA *CR, f 3350 — D0153 Consideration of the benefit of additional intravitreal anti-vascular endothelial growth factor injection in polypoidal choroidal vasculopathy patients with chronic subfoveal subretinal fluid.Jeehyun Kim, Y. Kim, K. Kim. Keimyung University Dongsan Medical Center, Daegu, Korea (the Republic of) 3352 — D0155 Retinal angiomatous Proliferations- does the treatment outcome depend on the stage? A retrospective follow-up. Johanna Maass. Ophthalmology, Universitätsklinikum Carl Gustav Carus, Dresden, Germany 3354 — D0157 An overview of medical practices in neovascular age-related macular degeneration: evaluating the changes in France between 2013 and 2016. Nathalie San Nicolas1, V. Gualino2, J. Zerbib3, T. Grenet4, M. Streho5, J. Halfon6, P. Cornut7, A. Bourhis8, C. Maurin1, H. Masse9. 1Novartis Pharma SAS, RueilMalmaison, France; 2Ophtalmology, Clinique Honoré Cave, Montauban, France; 3Ophtalmology, Private practice, Nice, France; 4Centre Imagerie et Laser, Paris, France; 5Centre Exploration de la Vision, Rueil-Malmaison, France; 6Cabinet D’ophtalmologie des Halles de Tours, Tours, France; 7Pôle Vision, Clinique Du Val d’Ouest, Lyon, France; 8Ophtalmology, Polyclinique de L’Atlantique, Saint-Herblain, France; 9 Ophtalmology, CHU Nantes, Nantes, France *CR 3355 — D0158 Efficacy of Aflibercept in Treatment-naïve Neovascular Age-related Macular Degeneration: Two-Year Real World Outcomes. Maria Eleftheriadou, C. VazquezAlfageme, M. C. Citu, R. R. Crosby-Nwaobi, S. Sivaprasad, P. Hykin, R. D. Hamilton, P. J. Patel. NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom *CR 3356 — D0159 Recurrences in neovascular age related macular degeneration: are they predictable in a clinical setting? Stefano Erba, G. Delledonne, C. D. Bianchi, M. Cozzi, A. Babbi, M. V. Cigada, F. Bottoni, G. Staurenghi. Biomedical and clinical sciences “Luigi Sacco”, Sacco Hospital Eye Clinic, University of Milan, Milano, Italy *CR 3357 — D0160 Fc receptor inhibition reduces susceptibility to oxidative stress in human RPE cells treated with bevacizumab, but not aflibercept. Mahdy Ranjbar, M. Brinkmann, D. Zapf, Y. Miura, M. Rudolf, S. Grisanti. Ophthalmology, University of Lübeck, Lübeck, Germany 3358 — D0161 Comparative Effects of Bevacizumab and Aflibercept on VEGF and IGF Signaling in Human Retinal Endothelial Cells Exposed to Hyperoxia and Intermittent Hypoxia. Amirfarbod Yazdanyar, C. Cai, A. Taimur, E. shrier, D. R. Lazzaro, G. Valencia, J. Aranda, K. Beharry. Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY 3359 — D0162 No improvement in visual outcome over time in two cohorts from the same county in patients treated for wet AMD. Marion Schroeder, L. Rung, M. K. Lovestam Adrian. Lund University, Malmö, Sweden 3360 — D0163 Impact of practice modifications on infectious endophthalmitis rates following intravitreal injection of anti-vascular endothelial growth factor. Maya Maloney, A. Barkmeier, S. J. Bakri, R. Iezzi, J. Pulido, W. Smith, J. Erie. Mayo Clinic, Rochester, MN *CR 3361 — D0164 Suppression of laser-induced choroidal neovascularization by intravitreal injection of collagen type Ii, alpha 1 peptide in mouse model. Byul-Nim Ahn, D. Hur, J. Yang, S. Kim. Inje Univ. Busan Paik hospital, Busan, Korea (the Republic of) 3362 — D0165 Adherence to treatment determines 5-year outcome in neovascular AMD in a real-life setting. Robert G. Wilke, H. G. Sachs. KH Dresden - Friedrichstadt, Dresden, Germany *CR 3363 — D0166 Ranibizumab, Bevacizumab, and Aflibercept accumulation and their effect on cell migration and permeability on human ARPE-19 cells. Patricia Fernandez1, 2, M. Saenz de Viteri1, S. Recalde1, 2, M. Hernandez1, 2, J. Bezunartea-Bezunartea1, 2, E. Alonso1, M. Moreno-Orduna1, N. Aguado1, I. Belza1, A. Garcia-Layana1, 2. 1Experimental Ophthalmology Laboratory, Clinica Universidad de Navarra, Pamplona, Spain; 2IdiSNA, Navarra Institute for Heatl Research, Pamplona, Spain *CR 3364 — D0167 Peripapillary Choroidal Thickness Change of Polypoidal Choroidal Vasculopathy after Anti-Vascular Endothelial Growth Factor Treatment. Kyou Ho Lee, J. Lee. Ophthalmology, Severance hospital, Yonsei University, Seoul, Korea (the Republic of) The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 232 Tuesday – Posters – 3365 – 3382 3365 — D0168 Clinical outcomes of treatment switching in neovascular age-related macular degeneration (nAMD): a retrospective cohort study in the United States (US) using electronic medical records. Frances Milnes1, R. Griner2, A. Ferreira1, A. Skelly3, P. U. Dugel4. 1Novartis Pharma AG, Basel, Switzerland; 2IMS Health Inc., Burlington, MA; 3Novartis Ireland Limited, Dublin, Ireland; 4Retinal Consultants of Arizona, Phoenix, AZ *CR 3366 — D0169 Systemic Pharmacodynamic Effects of Anti-Vascular Endothelial Growth Factor (VEGF) Agents in Patients With Wet AgeRelated Macular Degeneration. Peter K. Kaiser1, L. Kodjikian2, J. Korobelnik3, O. Zeitz4, R. Vitti5, C. Metzig4, C. Ahlers4, T. dicioccio5, J. Hoechel4. 1 Ophthalmology, Cole Eye Institute, Cleveland, OH; 2Hopital de la Croix-rousse, Lyon, France; 3 Université de Bordeaux, Bordeaux, France;4Bayer Pharma AG, Berlin, Germany; 5Regeneron Pharmaceutical Inc., Tarrytown, NY *CR, f 3368 — D0171 Ranibizumab treatment according to the subtypes of choroidal neovascularisation due to neovascular Agerelated Macular Degeneration in a real-life. 3 years interim analysis of a French national observational and multicentric retrospective study: COLOR. David Sayag1, F. Coscas2, G. Mimoun3, C. Favard2, C. Francais-Maury2, V. Krivosic2, V. Pierre-Kahn1. 1Rétina, Centre Exploration Vision, PARIS, France; 2Centre Ophtalmologique de l’Odéon, Paris, France; 3Centre Ophtalmologique d’Imagerie de l’Ecole Militaire, Paris, France 3369 — D0172 Anatomical and functional effects of subretinal rAAV.sVEGFR-1 gene therapy on retinal-choroidal structures in nonhuman primates. Sharmila Vijay1, K. W. Woodburn1, P. Sharma1, T. W. Chalberg1, V. Woodley2, J. Attwood2, M. S. Lawrence2, M. Gasmi1. 1 Avalanche Biotechnologies, Menlo Park, CA; 2 RxGen Inc, Hamden, CT *CR 3370 — D0173 6 weeks PRN intravitreal treatments results for macular diseases. One year clinical practice data. Marcos J. Rubio Caso, R. Morwani Morwani, C. Veiga Sanchez-Tinajero, L. Arias Barquet, J. Caminal Mitjana. Hospital Universitari de Bellvitge, Sant Boi de Llobregat Barcelona, Spain *CR Tuesday, May 03, 2016 8:30 AM-10:15 AM Multidisciplinary Ophthalmic Imaging Group / Lens / Low Vision 325 Clinical Imaging - Miscellaneous Moderators: Linda M. Zangwill and Masahiro Miura 3371 — D0308 Window to the central nervous system-Retinal examination for early diagnosis of Alzheimer’s disease. Lily Yu-Li Chang1, 2, M. L. Acosta1, 2, J. Black1, 2. 1Optometry, University of Auckland, Auckland, New Zealand; 2New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand 3372 — D0309 Retinal Biomarkers of Alzheimer’s Disease. Heather Whitson1, 2, S. Farsiu3, S. S. Stinnett3, L. Kwark3, G. Potter4, J. Burke5, S. W. Cousins3, E. M. Lad3. 1Medicine, Duke University, Durham, NC; 2GRECC, Durham VA Medical Center, Durham, NC; 3Ophthalmology, Duke University, Durham, NC; 4Psychiatry and Behavioral Sciences, Duke University, Durham, NC; 5Neurology, Duke University, Durham, NC 3373 — D0310 Retinal imaging in early and late Alzheimer’s disease. Lajos Csincsik1, T. Shakespeare2, N. Quinn4, R. E. Hogg4, S. Crutch2, R. Craigh5, T. Peto3, 1, I. Lengyel1. 1ORBIT, UCL Institute of Ophthalmology, London, United Kingdom; 2Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom; 3 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 4Queen’s University - Centre for Experimental Medicine, Belfast, United Kingdom; 5 University of Edinburgh, Edinburgh, United Kingdom 3374 — D0311 A technique for measurement of ganglion cell and retinal nerve fiber layer thickness change with age in an Alzheimer’s disease (AD) mouse model using human spectral domain optical coherence tomography (OCT). Keegan Harkins, M. A. Sadiq, V. Gulati, S. J. Havens, S. Fan, T. Rudebush, D. A. Ghate. Ophthalmology, Truhlsen Eye Institute - UNMC, Omaha, NE 3375 — D0312 Assessment of corneal properties using Optical Coherence Tomography Speckle: A pilot study. Danilo A. Jesus, D. Iskander. Wroclaw University of Technology, Wroclaw, Poland 3376 — D0313 Microscope-integrated Intraoperative Optical Coherence Tomography Enables Real-Time Monitoring Of Corneal Structural Alterations During Collagen Crosslinking. Sebastian E. Siebelmann1, 2, J. Horstmann1, 2, M. M. Hermann1, B. Bachmann1, C. Cursiefen1, P. Steven1, 2. 1Department of Ophthalmology, University of Cologne, Cologne, Germany; 2Cluster of Excellence: Cellular Stress Responses in Aging-associated Diseases (CECAD), University Hospital of Cologne, Cologne, Germany *CR 3377 — D0314 A New Method for Measuring Corneal Epithelial Thickness. Esther Young, H. Bagherinia, P. Sha, M. K. Durbin. R&D, Carl Zeiss Meditec, Inc., Dublin, CA *CR 3378 — D0315 Non-invasive Assessments of the Sclera and Cornea after Collagen Crosslinking and Glycosaminoglycan Depletion using Multimodal MRI. Kevin C. Chan1, 2, L. C. Ho1, 4, I. A. Sigal2, 3, N. Jan2, 3, X. Yang1, 2, Y. van der Merwe1, 3, G. Wollstein2, 3, J. S. Schuman2, 3. 1NeuroImaging Laboratory, University of Pittsburgh, Pittsburgh, PA; 2UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 3Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA; 4 Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China *CR 3379 — D0316 Corneal subbasal nerve plexus Decreases in Limbal stem cell deficiency patients. Pichaya Chuephanich, C. Supiyaphun, C. Aravena Perez, T. Bozkurt, F. Yu, S. X. Deng. Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA 3380 — D0317 Pediatric Anterior Segment Ultrasound Biomicroscopy Image Analysis: Intra and Inter-observer Agreement. Haoxing Chen1, A. Qureshi1, O. Saeedi2, 3, M. A. Kaleem2, 3, J. Margo2, 3, S. Kalarn3, J. D. Leath2, 3. 1University of Maryland School of Medicine, Baltimore, MD; 2Department of Ophthalmology, University of Maryland Eye Associates, Baltimore, MD; 3Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 3381 — D0318 Assessment and Comparison of Automated Anterior Chamber Metrics between Casia Swept-Source OCT vs Pentacam Scheimpflug Imaging. Kenneth Marion1, 2, A. Dastiridou1, 2, B. Francis1, 2, V. Chopra1, 2. 1Doheny Eye Institute, Los Angeles, CA; 2University of California Los Angeles, Los Angeles, CA *CR 3382 — D0319 Anterior chamber angle imaging with Automatic Gonio-Photography. Carlo Alberto Cutolo1, A. Bagnis1, R. Scotto1, C. Bonzano1, P. Frascio1, M. Pascolini2, C. Tanassi2, C. E. Traverso1.1University Eye Clinic, University of Genoa, Genoa, Italy; 2NIDEK Technologies Srl, Padua, Italy *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 233 Tuesday Posters 8:30 am – 10:15 am 3367 — D0170 A systematic review to assess the “Treat-and-Extend” dosing regimen compared to monthly and as-needed dosing for neovascular age-related macular degeneration using ranibizumab.Sohaib R. Rufai1, 2, H. Almuhtaseb1, H. Lee1, 2, R. Paul2, B. Stuart2, T. Kendrick2, A. J. Lotery1, 2. 1Southampton Eye Unit, University Hospital Southampton, Southampton, United Kingdom; 2Faculty of Medicine, University of Southampton, Southampton, United Kingdom *CR Exhibit/Poster Hall D0308-D0351 3383 – 3405 – Tuesday – Posters 3383 — D0320 Imaging of aqueous outflow system structures using ultrahigh-resolution optical coherence tomography. Rene M. Werkmeister1, S. Sapeta1, V. Aranha dos Santos1, G. Garhofer2, L. Schmetterer1, 2. 1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 2Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria 3384 — D0321 Blood-neural-barrier disruption has different effects on fluorescein angiography dynamics in the eye and brain. Flora Hui1, C. T. Nguyen1, Z. He1, R. Gurrell2, R. Fish2, A. J. Vingrys1, B. V. Bui1. 1University of Melbourne, Melbourne, VIC, Australia; 2Neuroscience and Pain Research Unit, Pfizer, Cambridge, United Kingdom *CR Tuesday Posters 8:30 am – 10:15 am 3385 — D0322 Modeling and experimental testing of iris thermal damage limits. David Dewey, A. Vankov, G. Schuele. R&D, Abbott Medical Optics, Sunnyvale, CA *CR 3386 — D0323 Measurement of Iris Lesion Volume with Anterior Segment Swept-Source Optical Coherence Tomography. Laura Vickers1, H. AKIL1, 2, E. Baghdasaryan1, 2, O. L. Lee1, 2. 1 Ophthalmology, Doheny Eye Institute-UCLA, Pasadena, CA; 2Doheny Image Reading Center, Los Angeles, CA 3387 — D0324 Video imaging during visual field perimetry. Jacques R. Charlier1, X. Zanlonghi2. 1Research, Metrovision, Perenchies, France; 2Clinique Sourdille, Nantes, France *CR 3388 — D0325 Ocular biometric parameters variation between closed and opened angles in Thai population. Kulawan Rojananuangnit, P. Salyapongse. Ophthalmology, Mettapracharak(Wat Rai Khing) hospital, Nakhon Pathom, Thailand 3389 — D0326 Novel fshape mapping of peripapillary RNFL and choroidal thickness for group-wise comparison of glaucoma and healthy aging. Sieun Lee1, K. Popuri1, J. A. Matsubara2, B. Eadie2, A. Merkur2, P. MacKenzie2, M. V. Sarunic1, M. Beg1. 1Simon Fraser University, Vancouver, BC, Canada; 2University of British Columbia, Vancouver, BC, Canada 3390 — D0327 Imaging of scar tissue in the filtering bleb by anterior-segment polarizationsensitive OCT. Masahiro Yamanari1, S. Tsuda2, T. Kokubun2, 3, K. Omodaka2, Y. Yokoyama2, N. Himori2, S. Kunimatsu-Sanuki2, K. Maruyama2, H. Kunikata2, T. Nakazawa2. 1Tomey Corporation, Nagoya, Japan; 2Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Ophthalmology, Katta General Hospital, Shiroishi, Japan *CR 3391 — D0328 Assessment of diagnostic information acquired by Transverse Section Enhanced Depth Imaging Optical Coherence Tomography in Patients with Optic Nerve Head Drusen. Katharina Blobner, M. M. Maier, N. Feucht. Department of Ophthalmology, Technische Universität München, Munich, Germany 3392 — D0329 Three Dimension Spectral Domain Optical Coherence Tomography: an Important Tool for Diagnosis, Treatment and Follow-up of Optic Disc Pit in Elderly Patients. Luis Alberto Zeman Bardeci, M. Iglicki, M. Cotic, M. Mendaro, L. Adamo, J. Bar, P. Chiaradia, M. Zas. División Oftalmología, Hospital de Clínicas, City of Buenos Aires, Argentina 3393 — D0330 Distinguishing Ischemic Optic Neuropathy from Optic Neuritis by Ganglion Cell Analysis. Carlos E. Mendoza1, 2, N. ErlichMalona1, N. Patel1, 3, C. Monaco1, E. Cole1, T. Hedges1. 1New England Eye Center, Tufts Medical Center. Tufts University, Boston, MA; 2 Neurology, New York University, New York, NY; 3 Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 3394 — D0331 RetinAsk Update: Image and Image Analysis, Worth a Million Words? Jessica Taibl, S. I. Sayegh. The EYE Center, Champaign, IL 3395 — D0332 Torsional Indirect Traumatic Optic Neuropathy (TITON): Identifying Biomarkers of Trauma using Matrix Assisted Laser Desorption/Ionization (MALDI). Kirstin Jones1, R. D. Glickman2, B. I. Asemota3, M. A. Reilly1. 1Biomedical Engineering, UTSA, San Antonio, TX; 2UTHSCSA, San Antonio, TX; 3St. Louis University School of Medicine, St. Louis, MO 3396 — D0333 Thickness of the macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer in branch retinal vein occlusion : the repeatability study of spectral domain optical coherence tomography. Min Su Kim1, H. Lim1, K. Shin1, J. Kim1, 2. 1Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea (the Republic of); 2R & D Division, Chungnam Natl Univ Hosp, Daejeon, Korea (the Republic of) 3397 — D0334 Predicting future visual acuity outcomes from early morphologic and functional response in anti-VEGF treated retinal vein occlusion. Wolf-Dieter Vogl1, S. M. Waldstein2, B. Gerendas2, T. Schlegl1, J. Wu2, D. Podkowinski2, U. Schmidt-Erfurth2, G. Langs1. 1 Medical University of Vienna, Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Computational Imaging Research Lab, Vienna, Austria; 2Medical University of Vienna, Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Vienna Reading Center, Vienna, Austria *CR 3398 — D0335 Evolution of Short-wavelength Autofluorescence changes in Central Serous Chorioretinopathy over 12 months. Marta Zola3, P. Sanghi2, N. Patrao3, D. Menon3, P. Hykin1, S. Sivaprasad1.1NIHR Moorfields Biomedical Research Center, London, United Kingdom; 2University College London, Institute of Ophthalmology, London, United Kingdom; 3 Moorfields Eye Hospital, London, United Kingdom *CR 3399 — D0336 New Public Retinal Image Database for Tortuosity Evaluation. Jeffrey C. Wigdahl1, R. Annunziata2, L. Hughes3, S. Borooah4, A. Ruggeri1, E. Trucco2. 1Information Engineering, University of Padova, Padova, Italy; 2Vampire Project, School of Science and Engineering (Computing), University of Dundee, Dundee, United Kingdom; 3College of Medicine and Veterinary Medicine, University of Edinburgh, Edinbrugh, United Kingdom; 4Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom 3400 — D0337 A retrospective, observational analysis of the impact of a telemedicine system to identify ocular disease in patients with diabetes mellitus screened in a non-eye care medical setting. Ingrid E. Zimmer-Galler1, Y. Chu2, C. Y. Weng2, J. A. Martinez3, S. gupta4. 1Clinical-Retina, Johns Hopkins Medical Institutions, Baltimore, MD; 2Baylor College of Medicine, Houston, TX; 3 Austin Retina, Austin, TX; 4Retinal Specialty Institute, Pensacola, FL *CR 3401 — D0338 Quantitative Fundus Autofluorescence (qAF) in Diabetic Patients. Andrew Hsu, M. Ahmad, T. Smith. Ophthalmology, New York University School of Medicine, New York, NY 3402 — D0339 The prognostic effect of peripheral non-perfusion on macular thickness and visual acuity in diabetic and venous occlusive retinopathies. Razek Georges Coussa, C. Archambault, M. Mikhail, F. Antaki, D. E. Lederer. Ophthalmology, McGill University, Montreal, QC, Canada *CR 3403 — D0340 Automated Detection and Classification of Longitudinal Retinal Changes Due to Microaneurysms for Diabetic Retinopathy Screening. Kedir Adal1, 3, P. van Etten2, J. Martinez2, K. Rouwen2, L. Vliet3, K. A. Vermeer1. 1Rotterdam Ophthalmic Inst, Rotterdam, Netherlands; 2Rotterdam Eye Hospital, Rotterdam, Netherlands; 3Delft University of Technology, Delft, Netherlands 3404 — D0341 Combining Medical Data and Fundus Images to Detect Eye Diseases in Patients with Diabetes. Carla Agurto Rios1, S. C. Nemeth1, G. Zamora1, W. Bauman2, P. Soliz1, E. Barriga1.1VisionQuest Biomedical LLC, Albuquerque, NM; 2Retina Institute of South Texas, San Antonio, TX *CR 3405 — D0342 Fluorescence Lifetime Imaging Ophthalmoscopy in Diabetic Retinopathy. Martin Hammer1, 2, J. Schmidt1, S. Peters1, L. Sauer1, N. Müller3, M. Klemm4, R. Augsten1, D. Meller1.1Ophthalmology, University Hospital Jena, Jena, Germany; 2Center for Medical Optics and Photonics, Univ. of Jena, Jena, Germany; 3internal Medicine, University Hospital Jena, Jena, Germany; 4 Technical University, Ilmenau, Germany The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 234 Tuesday – Posters – 3406 – 3414 3406 — D0343 Can Retinal Vascular Geometry predict future progression of Diabetic Retinopathy? Maged Habib2, B. Al-Diri1, R. R. Crosby-Nwaobi3, S. Sivaprasad3, D. Steel2. 1 Computer Science, Lincoln University, Lincoln, United Kingdom; 2Sunderland Eye Infirmary, Sunderland, United Kingdom; 3Moorfields Eye Hospital, London, United Kingdom 3414 — D0351 Comparison of Common Radiographic Techniques in Identifying Intraoperatively “Lost” Surgical Needles and Vitrectomy Trocars. Yigit Akduman2, J. M. Newman3, M. Zulfiqar1, E. I. Akduman1. 1Saint Louis University, St. Louis, MO; 2Clayton High School, St. Louis, MO; 3SureVision, St. Louis, MO 3407 — D0344 Atypical vascularization of the foveal avascular zone in the human macula. Delia DeBuc1, J. Tian1, T. R. Campagnoli1, W. Lee1, H. Jiang1, J. Wang1, S. -. Reuven2, A. Grinvald5, W. E. Smiddy1, G. M. Somfai3, 4. 1Ophthalmology, University of Miami, Miami, FL; 2Optical Imaging, Ltd, Rehovot, Israel; 3Retinology Unit, Pallas Kliniken, Olten, Switzerland; 4Ophthalmology, Semmelweis University, Budapest, Hungary; 5 Weizmann Institute of Science, Rehovot, Israel *CR Tuesday Posters 8:30 am – 10:15 am 3408 — D0345 Optical Coherence Tomography Minimum Intensity as an objective measure for the detection of hydroxychloroquine toxicity. Ali M. Allahdina1, P. F. Stetson2, W. T. Wong1, E. Y. Chew1, C. A. Cukras1. 1National Eye Institute, NIH, Bethesda, MD; 2Research and Development, Carl Zeiss Meditec, Dublin, CA *CR, f 3409 — D0346 Quantitative fundus autofluorescence in patients treated with hydroxychloroquine. Francesco Viola1, 2, M. Di Nicola3, 2, E. Benatti3, 2, E. Tabacchi2, R. Clerici3, A. Santaniello2, A. Invernizzi2.1Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; 2Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; 3 University of Milan, Milan, Italy 3410 — D0347 Lipofuscin RPE Imaging in Vegetarians and Non-vegetarians: Dietary and Age Effects. Pooja A. Padgaonkar, S. S. Kommana, L. Wu, N. Mendez, B. C. Szirth, A. S. Khouri. Rutgers-New Jersey Medical School, Newark, NJ 3411 — D0348 Retinal and choroidal features in active posterior uveitis and panuveitis assessed by swept-source optical coherence tomography. Alfredo Adan Civera, J. Matas, A. De Pouplana, V. Llorenç, M. Mesquida, A. Sala, M. Sainz de la Maza, J. Zarranz-Ventura. Ophthalmology, Hospital Clinic, Barcelona, Spain 3412 — D0349 Correlation In Retinal Nerve Fiber Layer Thickness In Uveitis And Healthy Eyes Using Scanning Laser Polarimetry And Optical Coherence Tomography. David Bellocq, L. Kodjikian, P. Denis. Ophthalmology, Croix Rousse University Hospital, LYON, France 3413 — D0350 Ultra-Widefield Fluorescein Angiography in Intermediate Uveitis. Wipada Laovirojjanakul, N. Acharya, J. A. Gonzales. Uveitis, Francis I. Proctor Foundation, UCSF, San Francisco, CA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 235 Tuesday – General Business Meeting Room 618/620 Tuesday, May 03, 2016 10:15 AM-10:55 AM 326 General Business Meeting - Welcome - ARVO President, Dr. John Clark, MD, FARVO - Presentation of ARVO Distinguished Service Awards - ARVO President, Dr. John Clark, MD, FARVO - Dr. William Mieler, MD, FARVO - Dr. Dimitri Azar, MD, MBA, FARVO - Dr. Linda McLoon, PhD, FARVO - Presentation of the Joanne G. Angle Award to Dr. Sheila West, PhD, FARVO - ARVO President Dr. John Clark, MD, FARVO Tuesday General Business Meeting 10:15 am – 10:55 am - Presentation of the VSS Award to Kavitha Ratnam, BSc, - ARVO President Dr. John Clark, MD, FARVO - Presentation of Certificate of Appreciation to Dr. David Huang for his outstanding contributions to ARVO’s “Telling the Story of OCT” Project ARVO President, Dr. John Clark, MD, FARVO - Presentation of the David L. Epstein Award to Dr. Jonathan G. Crowston, MBBS, PhD - ARVO Foundation Chair, Dr. Mark Petrash, PhD, FARVO - Presentation of Membership Update and Election Results - ARVO Executive Vice President, Dr. Craig E. Crosson, PhD, FARVO - Introduction of Incoming Officers - ARVO Executive Vice President, Dr. Craig E. Crosson, PhD, FARVO - Dr. Crosson presents the membership and annual meeting attendance update - Dr. Crosson presents the election results for EVP and EIC positions - Dr. Crosson presents the 2016-2017 Board officers - Conclude Meeting - ARVO Executive Vice President, Dr. Craig E. Crosson, PhD, FARVO The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 236 Tuesday – Papers/Minisymposium – 3415 – 3427 Room 6A Tuesday, May 03, 2016 11:00 AM-12:45 PM Glaucoma 327 Glaucoma Visual Fields and Visual Function Moderators: Allison M. McKendrick and Lyne Racette 3415 — 11:00 The effect of ametropia on glaucomatous visual field loss. Tobias Elze1, 2, L. Shen3, M. Wang1, M. V. Boland4, S. Wellik5, C. De Moraes6, J. S. Myers8, P. Bex7, L. R. Pasquale3. 1 Schepens Eye Research Institute, Harvard Medical School, Boston, MA; 2Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany; 3 Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; 4Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 5Bascom Palmer Eye Institute, Miami, FL; 6Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY; 7Northeastern University, Boston, MA; 8Wills Eye Hospital, Philadelphia, PA *CR 3417 — 11:30 The Influence of Perimetric Stimulus Size on Defect Detectability in Early Glaucoma. John G. Flanagan1, P. H. Artes2, M. Wall3, E. Young4, T. Callan4, V. Patella4, M. Monhart4, 5, G. C. Lee4. 1School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA; 2Plymouth University, Plymouth, United Kingdom; 3University of Iowa, Iowa City, IA; 4Carl Zeiss Meditec, Dublin, CA; 5Carl Zeiss AG, Feldbach, Switzerland *CR 3418 — 11:45 Cognitive Decline is Associated with Increased Visual Field Variability in Glaucoma. Maria Valeria C. Silva1, 2, A. DinizFilho1, 2, S. Cronemberger2, F. A. Medeiros1. 1 Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Department of Ophthalmology and Otorhinolaryngology, Federal University of Minas Gerais, Belo Horizonte, Brazil*CR 3420 — 12:15 Relationship between Subjective Driving Concerns and Objective Driving Performance on a Simulator in Patients with Glaucomatous Visual Field Loss. Priscila C. Correa1, 2, C. P. Gracitelli1, 2, E. R. Boer1, A. Diniz-Filho1, A. Paranhos Jr.2, F. A. Medeiros1. 1 Laboratory of Performance and Visual Fuction, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Departament of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil *CR 3421 — 12:30 Predicting Patient-Reported Disability in Glaucoma from Results of Standard Automated Perimetry. Ricardo Y. Abe1, 2, A. Diniz-Filho1, C. P. Gracitelli1, F. A. Medeiros1. 1 Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Department of Ophthalmology, University of Campinas UNICAMP, Campinas, Brazil *CR Room 6B Tuesday, May 03, 2016 11:00 AM-12:45 PM Retina 328 OCT Angiography 2 Moderators: Philip J. Rosenfeld and Richard B. Rosen 3422 — 11:00 The features of age-related macular degeneration imaged by optical coherence tomography based angiography. Ruikang K. Wang1, Q. Zhang1, C. S. Lee1, K. Attaran-Rezaei1, P. J. Rosenfeld2.1Ophthalmology, University of Washington, Seattle, WA; 2Bascom Palmer Eye Insitute, University of Miami Miller School of Medicine, Miami, FL *CR 3424 — 11:30 Angiographic optical coherence tomography (OCT) of subretinal hyperreflective material (SHRM). Kunal K. Dansingani1, 5, F. Gilani1, 5, N. Phasukkijwatana2, 6, E. A. Novais3, L. Querques4, D. Sarraf2, 7, N. K. Waheed3, J. S. Duker3, G. Querques4, L. Yannuzzi1, 5, K. Freund1, 5. 1Vitreous Retina Macula Consultants of New York, New York, NY; 2Stein Eye Instutute UCLA, Los Angeles, CA; 3 New England Eye Center, Tufts University School of Medicine, Boston, MA; 4University Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan, Italy; 5LuEsther T. Mertz Retinal Research Center, New York, NY; 6Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; 7Stein Eye Institute, Greater Los Angeles VA Health Center, Los Angeles, CA *CR 3425 — 11:45 OCT-based angiography of choroidal neovascularization by removing projection artifacts. Qinqin Zhang1, A. Zhang1, C. S. Lee1, A. Lee1, L. Roisman2, G. Gregori2, M. K. Durbin3, L. An3, P. F. Stetson3, P. J. Rosenfeld2, R. K. Wang1. 1University of Washington, Seattle, WA; 2 Bascom Palmer Eye Insitute, Miami, FL; 3Carl Zeiss Meditec. Inc, Dublin, CA *CR 3426 — 12:00 A Comparison of Optical Coherence Tomography Angiography to Fluorescein Angiography for the Imaging of Type 1 Neovascularization. Maiko Inoue1, 2, J. J. Jung3, 2, C. Bala2, 4, T. E. de Carlo5, A. Shahlaee6, M. A. Klufas8, J. S. Duker5, A. C. Ho6, M. Quaranta El-Maftouhi7, D. Sarraf8, K. Freund2, 4. 1Yokohama City University Medical Center, Yokohama, Japan; 2 Vitreous Retina Macula Consultants of New York, New York, NY; 3East Bay Retina Consultants, Inc., Oakland, CA; 4The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY; 5New England Eye Center and Tufts Medical Center, Tufts University, Boston, MA; 6Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA; 7Centre Ophtalmologique Rabelais, Lyon, France; 8Stein Eye Institute at UCLA, Los Angeles, CA *CR 3427 — 12:15 Sensitivity and specificity of choroidal neovascularization detection in agerelated macular degeneration with optical coherence tomography angiography. Ambar Faridi1, 2, Y. Jia1, S. S. Gao1, K. Bhavsar1, 2, D. J. Wilson1, A. Sill1, C. J. Flaxel1, T. S. Hwang1, A. Lauer1, D. Huang1, S. T. Bailey1. 1Ophthalmology, Oregon Health & Science University, Casey Eye Institute, Portland, OR; 2Ophthalmology, VA Portland Health Care System, Portland, OR *CR 3423 — 11:15 Exploring choriocapillaris under reticular pseudodrusen using OCT-Angiography. Florian Alten, P. Heiduschka, C. R. Clemens, N. Eter. Ophthalmology, University Eye Hosp Muenster, Muenster, Germany *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 237 Tuesday Papers/ Minisymposium 11:00 am – 12:45 pm 3416 — 11:15 Disrupted Ocular Motor Behaviour in Preperimetric Glaucoma. Dan Milea1, S. Sharma1, M. Drouet2, S. Leruez2, M. Baskaran3, M. E. Nongpiur3, T. Aung5, O. White4, C. Lamirel6. 1Visual Neuroscience Group, Singapore Eye Research Institute, Singapore, Singapore; 2 University Angers, Angers, France; 3SERI, Singapore, Singapore; 4University of Melbourne, Melbourne, SA, Australia; 5Singapore Eye Research Institute, Singapore, Singapore; 6Fondation Rothschild, Paris, France 3419 — 12:00 Detection of Glaucoma Progression is Delayed in African Descent Compared to European Descent Subjects. Carolina P. Gracitelli1, 2, L. M. Zangwill1, A. Diniz-Filho1, R. Y. Abe1, R. N. Weinreb1, C. A. Girkin3, J. M. Liebmann4, F. A. Medeiros1. 1 Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil; 3School of Medicine, University of Alabama, Birmingham, Alabama, Birmingham, AL; 4Harkness Eye Institute, Columbia University Medical Center, New York, New York., New York, NY *CR 3428 – 3444 – Tuesday – Papers/Minisymposium 3428 — 12:30 Optical Coherence Tomography Angiography of Choroidal Neovascularization and Inflammatory Pigment Epithelial Detachments Occurring in Idiopathic Multifocal Choroiditis. Sarwar Zahid1, J. J. Jung2, K. C. Chen1, T. R. Kaden1, Q. Ghadiali3, C. Bala3, S. Rofagha2, K. Freund3, 1, L. Yannuzzi3, 1. 1 Ophthalmology, New York University, New York, NY; 2East Bay Retina Consultants, Inc., Oakland, CA;3Vitreous Retina Macula Consultants of New York, New York, NY Room 6C Tuesday, May 03, 2016 11:00 AM-12:45 PM Retina 329 Retinal Vascular Diseases Tuesday Papers/ Minisymposium 11:00 am – 12:45 pm Moderators: Susumu Ishida and Baruch D. Kuppermann 3429 — 11:00 Retinal non-perfusion in the posterior pole determines risk of neovascularisation in central retina vein occlusion. Luke Nicholson, C. Vazquez-Alfageme, N. V. Patrao, I. Triantafyllopoulou, P. Hykin, S. Sivaprasad. NIHR Moorfields Biomedical Research Centre and UCL Institute of Ophthalmology, London, United Kingdom *CR 3430 — 11:15 Impact of initial visual acuity on anti-VEGF treatment outcomes in patients with macular edema secondary to retinal vein occlusions. Karen M. Wai1, 2, M. Khan1, F. Silva1, S. K. Srivastava1, J. P. Ehlers1, A. Rachitskaya1, P. K. Kaiser1, A. Schachat1, A. Babiuch1, A. Yuan1, R. Singh1. 1Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 2Case Western Reserve University School Of Medicine, Cleveland, OH *CR 3431 — 11:30 Effect of intravitreal dexamethasone implant on intraocular cytokines and chemokines in eyes with branch and central retinal vein occlusion. Sandra Rezar2, K. Eibenberger2, A. Pollreisz2, W. Buehl2, M. Georgopoulos2, C. Krall1, G. Weigert2, U. Schmidt-Erfurth2, S. Sacu2. 1Department of Medical Statistics, Medical University of Vienna, Vienna, Austria; 2Department of Ophthalmology, Medical University of Vienna, Vienna, Austria *CR, f 3432 — 11:45 Safety and efficacy of ranibizumab 0.5 mg vs dexamethasone 0.7 mg intravitreal implant in patients with branch or central retinal vein occlusion: long-term results of the COMRADE-Extension study. Nicolas Feltgen1, T. Bertelmann2. 1Ophthalmology, University Hospital, Goettingen, Germany; 2 Clinical Research Retina, Novartis Pharma GmbH, Nuernberg, Germany *CR, f 3433 — 12:00 A Novel Experimental Model for Investigating the Role of Microglial Cells in Retinal Edema. Hannah Canter1, A. C. Palacio1, H. Lu1, B. G. Borghuis2, S. Schaal1. 1Department of Ophthalmology and Visual Scineces, University of Louisville School of Medicine, Louisville, KY; 2Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 3434 — 12:15 Novel software to assess correlation between MAIA microperimetry and OCT imaging of ellipsoid zone in type 2 idiopathic macular telangiectasia. Eleonora M. Lad1, D. Mukherjee1, R. R. Vann2, T. E. Clemons3, E. Y. Chew4, G. J. Jaffe1, S. Farsiu5. 1Ophthalmology, Duke Eye Center, Durham, NC; 2Research Triangle High School, Durham, NC; 3Ophthalmology, EMMES, Rockville, MD; 4Division of Epidemiology and Clinical Applications, National Eye Institute, Bethesda, MD; 5Biomedical Engineering, Duke University Medical Center, Durham, NC *CR, f 3435 — 12:30 Biological rationale for the clinical effect of aflibercept in patients with idiopathic macular telangiectasia type 1. Laura Kowalczuk1, A. Dirani1, A. Matet1, A. Daruich1, A. Ambresin1, I. Mantel1, N. Turck2, F. F. BeharCohen1. 1Department of ophthalmology, Jules Gonin eye hospital, University of Lausanne, Fondation Asile des aveugles, Lausanne, Switzerland; 2 Department of Human Protein Science, University of Geneva, Geneva, Switzerland 3439 — 11:45 Microvascular responses of the bulbar conjunctiva in dry eye. Alexandra Levitt1, W. Chen1, 2, A. Galor1, 4, J. Yuan1, 2, C. D. Sarantopoulos4, 3, N. Shalabi1, 4, H. I. Batawi1, 4, A. L. McClellan4, W. J. Feuer1, R. C. Levitt4, 3, J. Wang1. 1 Bascom Palmer Eye Institute, University of Miami, Miami, FL; 2Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, China; 3Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami, Miami, FL; 4 Miami Veterans Administration Medical Center, Miami, FL *CR 3440 — 12:00 Effects of punctal occlusion on tear protein levels in dry eye patients. Louis Tong1, L. Zhou1, R. W. Beuerman1, S. Simonyi2, D. A. Hollander2, M. E. Stern3. 1Singapore National Eye Centre, Singapore, Singapore; 2Allergan plc, Irvine, CA; 3Baylor College of Medicine, Mission Viejo, CA *CR, f 3441 — 12:15 Evaluation for Dropout Lesions on Infrared Meibography Using Optical Coherence Tomography Meibography. YoungSik Yoo1, Y. Byon1, C. Joo1, G. Yoon2. 1The Catholic University of Korea, Seoul, Korea (the Republic of); 2Rochester University, Rochester, NY 3442 — 12:30 Tear Lipid Layer Thickness and Variability Both Impact Tear Film Stability. Meng C. Lin1, 2, A. D. Graham2, P. Satjawatcharaphong2, W. Li1, 2, T. N. Yeh1, 2, M. Lerma2, K. Lin2. 1Vision Science Graduate Group, University of California, Berkeley, CA; 2Clinical Research Center, School of Optometry, University of California, Berkeley, CA Room 606/607 Tuesday, May 03, 2016 11:00 AM-12:45 PM Room 609 Cornea Tuesday, May 03, 2016 11:00 AM-12:45 PM 330 Dry Eye; Clinical and Epidemiology Moderators: Kyoungyul Seo and Penny A. Asbell 3436 — 11:00 Remote Assessment of Dry Eye Symptoms using two Web-Based Questionnaires. Francisco Amparo, R. Dana. Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA 3437 — 11:15 Association between Air Pollution and Dry Eye Disease in South Korea. Dong Hyun Kim1, S. Hwang1, Y. Choi2. 1Department of Ophthalmology, Gachon University Gil Medical Center, Incheon, Korea (the Republic of); 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Korea (the Republic of) 3438 — 11:30 Does dry eye severity correlate with somatosensory function in the V1 distribution of the trigeminal nerve? Anat Galor2, 1, B. Seiden2, K. T. McManus2, J. J. Park2, R. C. Levitt3, C. D. Sarantopoulos3, E. Felix4. 1 Ophthalmology, Bascom Palmer, Miami, FL; 2 Ophthalmology, Miami VAMC, Miami, FL; 3 Anesthesiology, Miami VAMC, Miami, FL; 4 Research Services, Miami VAMC, Miami, FL Lens 331 Lens Development Moderators: Jeffrey M. Gross and Judith A. West-Mays 3443 — 11:00 RNA sequencing analysis of Celf1 mouse mutants identifies a cohort of abnormally expressed lens development regulators. Archana D. Siddam1, D. Anand1, L. Paillard3, S. A. Lachke1, 2.1Dept of Biological Sciences, University of Delaware, Hockessin, DE; 2Center for computational biology and bioonformatics, University of Delaware, Newark, DE; 3institut de génétique et développement de rennes, Rennes, France 3444 — 11:15 Anisotropic geometry of lens placode cells is mediated by planar polarized inhibition of junctional contraction during invagination. Timothy F. Plageman. College of Optometry, The Ohio State University, Columbus, OH The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 238 Tuesday – Papers/Minisymposium – 3445 – 3462 3445 — 11:30 Conditional Deletion of Apaf-1 Disrupts Mouse Lens and Anterior Segment Development. Lixing W. Reneker, L. Wang, G. Chandran, A. Lueckenotte, R. Irlmeier. Ophthalmology, University of Missouri-Columbia, Columbia, MO 3446 — 11:45 Functional Dissection Shows FOXE3 Contributes to Peters Anomaly through the Transcriptional Regulation of an Autophagy Associated Co-Chaperone, DNAJB1. Shahid Y. Khan1, S. Vasanth1, F. Kabir1, A. O. Khan2, Z. Ma3, S. Riazuddin4, 5, N. Pourmand6, N. A. Zaghloul7, J. Hejtmancik3, S. Riazuddin1. 1 The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 2Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 3 Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD; 4 National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan; 5National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan; 6Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA;7Department of Medicine, University of Maryland, Baltimore, MD 3448 — 12:15 Functional Assessment of FYCO1 Underlines the Association with Autophagy and Confirms the Indispensable Role in Lens Development. Firoz Kabir1, S. Y. Khan1, S. Riazuddin2, 4, J. Akram3, 4, J. Hejtmancik5, S. Riazuddin1. 1The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 2National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan;3Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan; 4National Centre for Genetic Diseases, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan; 5 Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 3449 — 12:30 ADAM10 is a key regulator of NOTCH signaling. D J. Sidjanin1, 3, J. Toonen2. 1 Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI; 2Neurology, Washington University School of Medicine, St. Louis, MO; 3Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI Room 615/617 Tuesday, May 03, 2016 11:00 AM-12:45 PM Tuesday, May 03, 2016 11:00 AM-12:45 PM Visual Psychophysics/Physiological Optics / Clinical/Epidemiologic Research / Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology / Retina Physiology/Pharmacology 332 Optics of the eye and vision Minisymposium Moderator: Haydee E. Bazan Optics of the eye is the most important first step for vision which has been studied objectively using various methods to quantify optical quality of the eye. How the visual system perceives the retinal images formed through the eye’s optics is an intriguing question to ask. This minisymposium proposes to advance our understanding of how optics of the eye affects neural processing of retinal image quality and emmetropization. Moderators: Thomas W. Raasch and Geunyoung Yoon 3450 — 11:00 Introduction. Thomas W. Raasch. Ohio State University, Columbus, OH 3451 — 11:05 Neural mechanism of long-term adaptation to the eye’s aberration. Geunyoung Yoon. Flaum Eye Institute, University of Rochester, Rochester, NY; Center for Visual Science, University of Rochester, Rochester, NY 3452 — 11:25 Neural interpretation of optical blur and its impact on image quality perception. Susana Marcos. Instituto de Optica, CSIC, Madrid, Spain 3453 — 11:45 Peripheral optics of the eye and its relevance to visual performance and refractive error development. David A. Atchison. Queensland University of Technology, Brisbane, QLD, Australia 3454 — 12:05 Binocular combination of different monocular optical blurs. Martin Banks. Optometry & Vision Science, UC Berkeley, Berkeley, CA 3455 — 12:25 Comparison of different binocular approaches to overcome presbyopia. Pablo Artal. Lab. Optica, Universidad de Murcia, Murcia, Spain *CR 333 Drug Delivery 3456 — 11:00 Determination of the effect size of conjunctival and episcleral circulation on transscleral drug delivery. Bing Gu1, X. Li1, J. Liu1, X. Ding1, L. Cheng1, 2. 1Institute of Ocular Pharmacology, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; 2Department of Ophthalmology, University of California San Diego, Jacob’s Retina Center at Shiley Eye Institute, San Diego, CA 3457 — 11:15 Dendrimer Nanofibers for Ocular Drug Delivery. Michael G. Lancina1, S. Husain2, S. Singh2, H. Yang3. 1Biomedical Engineering, Virginia Commonwealth University, Richmond, VA; 2Ophthalmology, Medical University of South Carolina, Charleston, SC; 3 Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 3458 — 11:30 MiDROPS™ for Topical Delivery of Lipophilic Compounds to the Anterior and Posterior Segment of the Eye. Drew Wassel, C. Calbert, D. Nuno, A. Quiambao, J. Green, P. Vanlandingham, A. Dockins, A. Sparkes, E. Phelps, M. Lambros, R. Farjo. EyeCRO, Oklahoma City, OK 3459 — 11:45 Selective Episcleral Drug Delivery of Neuroprotective Drugs. Toxicokinetics of a Neuroprotective Estradiol Analog and Implications for Treatment of Traumatic and Neurodegenerative Ocular Conditions. Jacques Manders, J. Moreno, R. brito, M. C. Vargas-Dougherty, P. P. Ko, C. Mendes, G. C. Matsutani, R. A. De Carvalho. 3t Ophthalmics, Irvine, CA *CR 3460 — 12:00 An Injectable, Biodegradable, And Biocompatible Reverse Thermal Gel Designed for Controlled, Intra-vitreal Drug Delivery. yadong wang, T. R. Friberg, M. Sinha, H. Awada, X. Ding. university of pittsburgh, Pittsburgh, PA 3461 — 12:15 Intraocular Sustained Delivery System Of Flurbiprofen; Efficacy And Pharmacokinetics. Miltiadis K. Tsilimbaris1, S. Blazaki1, C. Tsika1, K. Pachis2, I. Naoumidi1, C. Tsatsanis1, M. Tzatzarakis1, S. Antimisiaris2. 1 Medicine, University of Crete, Heraklion, Greece; 2 Pharmacology, University of Patras, Patras, Greece 3462 — 12:30 Intranasal delivery of nanomicelle curcumin promotes corneal epithelial wound healing in streptozotocininduced diabetic mice. Xianggen Wu, C. Guo, M. Li, X. Qi, F. Cui, F. Li. Shandong Eye Institute, Qingdao, China f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 239 Tuesday Papers/ Minisymposium 11:00 am – 12:45 pm 3447 — 12:00 β1-integrin deletion from lens activates AKT signaling and EGR1 expression in the epithelium leading to fibrosis and apoptosis. Yichen Wang, A. M. Terrell, D. Anand, S. A. Lachke, M. K. Duncan. University of Delaware, Newark, DE Room 611/612 3463 – 3477 – Tuesday – Papers/Minisymposium Room Skagit 4/5, TCC Room Tahoma 1/2, TCC Tuesday, May 03, 2016 11:00 AM-12:45 PM Tuesday, May 03, 2016 11:00 AM-12:45 PM Immunology/Microbiology / Clinical/ Epidemiologic Research / Cornea / Lens / Physiology/Pharmacology / Retina Retinal Cell Biology 334 Eye and pregnancy Minisymposium There are physiological and immunological changes in the eye during pregnancy. Pregnancy also modifies the course of eye diseases or the indication for surgery (e.g. diabetic retinopathy, refractive surgery). In the end therapy during pregnancy is a challenge for both the ophthalmologist and the patient. There is uncertainty how to handle eye diseases in pregnant patients and also how to treat them without hazard to the unborn. The proposed minisymposium will present the latest state of knowledge regarding eye, immune system and pregnancy. Tuesday Papers/ Minisymposium 11:00 am – 12:45 pm Moderators: Friederike Mackensen, Thomas Ness and Lyndell L. Lim 3463 — 11:00 Physiological changes during pregnancy and mode of delivery. Thomas Ness. Eye Center, University of Freiburg, Freiburg, Germany *CR 3464 — 11:15 Immunity during pregnancy. David Klatzmann. University of Pierre and Marie Curie, Paris, France; Assistance Publique Hôpitaux de Paris, Paris, France 3465 — 11:45 Retina diseases in pregnancy. Emily Y. Chew. National Eye Inst/NIH, Bethesda, MD 3466 — 12:00 Uveitis in pregnancy. Lyndell L. Lim. Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia *CR 3467 — 12:15 Prenatal exposure in pregnancy: what ophthalmologists need to know. Christina D. Chambers. Pediatrics, University of California San Diego, La Jolla, CA; Family Medicine and Public Health, University of California San Diego, La Jolla, CA 335 Photoreceptor degeneration, rescue and live imaging Moderator: Michael Robichaux 3468 — 11:00 Mutation in human retinal membrane guanylyl cyclase 1 (RetGC1, GUCY2D) associated with CORD6 deregulates cGMP synthesis in photoreceptors and causes progressive blindness in transgenic mouse model. Alexander M. Dizhoor, E. V. Olshevskaya, I. V. Peshenko. Research, Salus University, Elkins Park, PA 3469 — 11:15 A novel, safe, non-invasive method to detect dying photoreceptors in the living rat. Francesca Mazzoni, C. Müller, S. C. Finnemann. Department of Biological Sciences, Center for Cancer, Genetic Diseases and Gene Regulation, Fordham University, Bronx, NY 3470 — 11:30 Interleukin-17 (IL-17) in Models of Retinal and RPE Degeneration. Jiyang Cai1, J. Chen1, P. Xu1, Z. Zhao1, Y. Cong2, Y. Chen1. 1 Ophthalmology, University of Texas Medical Branch, Galveston, TX; 2Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 3471 — 11:45 The neuroprotective effects of PARP inhibition in different types of photoreceptor degeneration. Ayse Sahaboglu1, S. Vagionitis2, A. Sharif3, M. Barth2, K. jiao4, M. Kulkarni1, D. Trifunovic1, M. Ueffing1, E. Zrenner1, F. Paquet-Durand1. 1Division of Experimental Ophthalmology, Institute of Ophthalmic Research, Tubingen, Germany; 2Graduate School of Cellular and Molecular Neuroscience, Tubingen, Germany;3Weizmann Institute of Science, Rehovot, Israel; 4The 2nd People’s Hospital of Yunnan Province, Kunming, China 3472 — 12:00 Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD? Christian Grimm1, M. Barben1, D. Ail1, B. Kast1, C. Schori1, C. GigerLange1, S. Michalakis2, M. Samardzija1. 1Lab for Retinal Cell Biol, Ophthalmology, University of Zurich, Schlieren / Zurich, Switzerland; 2Center for Integrated Protein Science Munich (CIPSM) and Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany 3473 — 12:15 Missing Motility: Highresolution in vivo imaging of retinal microglia reveals stationary ramified cells. Eric Miller1, P. Zhang2, 3, M. Goswami2, 3, R. J. Zawadzki3, 4, E. N. Pugh3, 2, M. E. Burns1, 4. 1Center for Neuroscience, UC Davis, Davis, CA; 2Cell Biology and Human Anatomy, UC Davis, Davis, CA; 3EyePod Rodent Imaging Laboratory, UC Davis, Davis, CA; 4 Ophthalmology and Vision Science, UC Davis, Davis, CA 3474 — 12:30 Investigating the molecular mechanisms of Late-Onset Retinal Degeneration using patient-specific induced pluripotent stem cells. Zoya Qureshy1, K. Miyagishima2, K. CloreGronenborn1, C. Zhang2, R. Sharma1, V. Rajan1, V. Khristov2, C. Cukras3, S. S. Miller2, K. Bharti1. 1 Unit on Ocular Stem Cell and Translational Research, National Eye Institute, National Institutes of Health, Bethesda, MD; 2Section on Epithelial & Retinal Physiology & Disease, National Eye Institute, National Institutes of Health, Bethesda, MD; 3Clinical Trials Branch, National Eye Institute, National Institutes of Health, Bethesda, MD Room Tahoma 3, TCC Tuesday, May 03, 2016 11:00 AM-12:45 PM Cornea 336 Corneal Wound Repair and Regenerative Medicine Moderators: James D. Zieske and Che J. Connon 3475 — 11:00 Adipose-derived Mesenchymal Stem Cells Therapy for Cornea Regeneration: A Multi-photon Intravital Study in a Mouse Model. Ladan Espandar1, J. Mandell1, T. Blanco2. 1 University of Pittsburgh, Pittsburgh, PA; 2Duke University, Durham, NC 3476 — 11:15 Mesenchymal stem cells restore corneal transparency via secretion of hepatocyte growth factor. Sharad Mittal, A. Amouzegar, M. Omoto, S. Chauhan. Schepens Eye Research Institute, Harvard Medical School, Boston, MA *CR 3477 — 11:30 Extracellular vesicles derived from human mesenchymal stem cells promote corneal wound repair by increasing epithelial cell proliferation and reducing neovascularisation in a rat corneal alkali burn model. Thomas Ritter1, C. Lal2, O. Treacy1, G. A. O’Malley1, S. Naicker1, H. Elbadawy3, A. E. Ryan1, G. Fahy4, M. J. Leahy2, M. Griffin1, S. Rani1. 1Regenerative Medicine Institute, Nt’l Univ of Ireland, Galway, Galway, Ireland; 2 School of Physics, College of Natural Sciences, National University of Ireland, Galway, Ireland, Galway, Ireland; 3The Veneto Eye Bank Foundation, Venice, Italy; 4Department of Ophthalmology, University Hospital Galway, National University of Ireland, Galway, Ireland, Galway, Ireland The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 240 Tuesday – Papers/Minisymposium – 3478 – 3488 3478 — 11:45 The Effect of Bone Marrow Mesenchymal Stem Cell Secretome on Corneal Epithelial Wound Healing. Medi Eslani1, A. Movahedan1, I. Putra1, J. Hamouie1, A. Tadepalli1, X. Shen1, N. Afsharkhamseh1, E. Ghahari1, P. Hematti2, A. R. Djalilian1. 1Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL; 2Division of Hematology/Oncology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 3479 — 12:00 Somatic Gene Therapy of Mucopolysaccharidosis with CRISPR/Cas9 Genome Editing. Winston W. Kao1, T. Ferreira1, F. Dong1, Y. Hu2, M. K. Call1, V. J. Coulson-Thomas1, J. Zhang1, T. Rice1. 1Ophthalmology, University of Cincinnati, Cincinnati, OH; 2Developmnetal biology, Cincinnati Children’s Hospital medical Center, Cincinnati, OH 3480 — 12:15 Quercetin inhibits corneal scar formation in vivo. Dimitrios Karamichos1, P. Kivanany2, T. B. McKay1, M. Petroll2. 1 Ophthalmology, Dean McGee Eye Institute/ OUHSC, Oklahoma city, OK;2University of Texas Southwestern Medical Center, Dallas, TX Tuesday, May 03, 2016 11:00 AM-12:45 PM Biochemistry/Molecular Biology 337 Next generation sequencing: What’s next? - Minisymposium High-throughput sequencing approaches of targeted, whole exome, and whole genome next generation sequencing (NGS) have been successful in identifying known and novel genes underlying inherited eye disorders. Determining the prevalence of gene defects, advancing the molecular biologic and pathway underpinnings and developing new drug targets for therapeutic trials are potential outcomes of this technology. Moderators: Christina Zeitz, Qingjiong Zhang and Marina S. Gorbatyuk — 11:00 Introduction 3482 — 11:04 Exome sequencing identifies novel gene defect in achromatopsia. Susanne Kohl. Inst for Ophthalmic Rsrch Tuebingen, Tuebingen, Germany 3483 — 11:18 Non-coding cis-acting genetic defects in inherited blindness: from targeted locus resequencing to interpretation. Elfride De Baere. Center for Medical Genetics, Ghent University and Ghent University Hospital, Ghent, Belgium 3484 — 11:32 Identifying elusive molecular defects underlying inherited retinal diseases employing stem cell technology and transcriptomics. Frans P. Cremers. Raboud university medical center, Nijmegen, Netherlands 3485 — 11:46 Bioinformatics prediction tools to help validating gene function defects. Vachiranee Limviphuvadh. Biomolecular Function Discovery Division, Bioinformatics Institute, A*STAR, Singapore, Singapore 3486 — 12:00 Revisiting the Mendelian disease paradigm: Lessons from next-generation sequencing for retinal and macular degenerative diseases. Anand Swaroop. National Eye Institute, Bethesda, MD 3487 — 12:14 Knowledge Base for sensory systems for biologists and clinicians. Thierry D. Leveillard. Institut De La Vision, Paris, France; Genetics, UPMC-UMRS 968, Paris, France 3488 — 12:28 Genetic signatures of rod and cone-dominant retinas and mouse models of retina degeneration. Krzysztof Palczewski. Case Western Reserve Univ, Cleveland, OH f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 241 Tuesday Papers/ Minisymposium 11:00 am – 12:45 pm 3481 — 12:30 ROCK Inhibitor HA1077: Potently Inhibits Corneal Fibrosis and Neovascularization. Michael K. Fink1, 5, S. Gupta1, 3, S. Ebers1, 4, E. Crider1, 4, M. Possin1, 4, E. A. Giuliano1, 3, P. R. Sinha1, 3, F. G. Rieger1, 4, R. R. Mohan1, 2. 1Harry S. Truman Veterans Hospital, Columbia, MO; 2Veterinary Medicine & Surgery, Biomedical Sciences, Veterinary Pathology, and Mason Eye Institute, University of Missouri, Columbia, MO; 3Veterinary Medicine & Surgery, University of Missouri, Columbia, MO; 4Mason Eye Institute, University of Missouri, Columbia, MO; 5 Veterinary Medicine & Surgery and Veterinary Pathology, University of Missouri, Columbia, MO Room Tahoma 4, TCC 3489 – 3507 – Tuesday – Posters Exhibit/Poster Hall A0092-A0142 Tuesday, May 03, 2016 11:00 AM-12:45 PM Cornea / Retinal Cell Biology 338 Corneal Neovascularization and Conjunctival Cell Biology and Surgery Moderators: Choun-Ki Joo and Pedram Hamrah 3489 — A0092 The Effect of Mitomycin C in Recurrent Pterygium Surgery with Amniotic Membrane Transplantation. Byung Yi Ko, K. Han. Ophthalmology, Konyang University College of Medicine and Hospital, Daejeon, Korea (the Republic of) 3490 — A0093 Validity of a new comprehensive pterygia grading scale for use in clinical research and clinical trial. Olivia L. Lee1, 2, P. Huang1, 2, J. Huang1, 2, T. Tepelus1, 2, S. R. Sadda1, 2. 1Doheny Image Reading Center, Doheny Eye Institute, Pasadena, CA; 2Doheny Eye Institute, UCLA, Los Angeles, CA *CR Tuesday Posters 11:00 am – 12:45 pm 3491 — A0094 Incidence and Clinical Characteristics of Stocker’s Line in Patients with Pterygium. Hiroto Obata, Y. Arai, S. Makino. Ophthalmology, Jichi Medical University, Tochigi, Japan 3492 — A0095 Risk Factors for Recurrence after Pterygium Surgery: An Image Analysis Study. Sang Beom Han1, 2, J. Hwang2, J. Hyon2, S. Lee1, J. Choi3. 1Ophthalmology, Kangwon National University Hospital, Chuncheon, Korea (the Republic of); 2Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of); 3Saevit Eye Hospital, Goyang, Korea (the Republic of) 3493 — A0096 Pterygium surgery: a simplified approach to optimal cosmesis and low recurrence. Rachel Shah, P. Channa. Ophthalmology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 3494 — A0097 Pterygium Surgery with Mitomycin C in a HispanoAmerican Population in Oaxaca, Mexico. Lucia Mendoza1, W. Teofilo1, C. Arriaga1, S. I. Sayegh2. 1Clinica Narmi, Oaxaca, Mexico; 2The EYE Center, Champaign, IL 3495 — A0098 Standardized strategy and longterm surgical outcomes in primary and recurrent pterygium. Seika Den, Y. Satake, N. Nakayama, T. Yamaguchi, J. Shimazaki. Ophthalmology, Tokyo Dental College Hospital, Chiba, Japan 3496 — A0099 Supra-Tenon’s Excision of Pterygium with 0.1ml Adjunctive Bevacizumab (STEP 0.1): A Novel Recurrence-Free Technique of Pterygium Surgery. Sayan Basu1, 3, R. Goyal1, A. Hoshing1, D. K. Mishra2, V. Dave3. 1Cornea and Anterior Segment, L V Prasad Eye Institute, Hyderabad, India; 2Ocular Pathology Laboratory, L V Prasad Eye Institute, Hyderabad, India; 3Center for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India 3497 — A0100 TITLE: Excision, Cryotherapy, and Postoperative Mitomycin C for the Treatment of Conjunctival-corneal Intraepithelial Neoplasia. Luana Campos, L. Pinheiro Teixeira, M. Martins Abrahao, B. A. Nassaralla, A. Nassaralla. Nuffield Dept of Clinical Neurosciences, Instituto de Olhos de Goiania, Goiania, Brazil *CR 3498 — A0101 Upper and Lower Conjunctival Fornix Depth in Healthy Caucasian Eyes: A Method of Objective Assessment. Valerie Saw1, 2, D. Carpenter3, S. Hau1, D. Booth1, H. Jasim1, E. Tay1, C. Daniel1, G. Jutley1. 1Cornea & External Disease, Moorfields Eye Hospital, London, United Kingdom; 2UCL Institute of Ophthalmology, London, United Kingdom; 3Ocular Prosthetics Department, Moorfields Eye Hospital, London, United Kingdom 3499 — A0102 Giant Conjunctival CystsClinical Features of 13 Cases. Mamta V. Shah1, N. Farber1, C. L. Shields2, J. A. Shields2, M. Dweck3, O. Gorenburg4, E. Wladis5, T. Nakra6, R. Allen7, R. Shinder1.1Ophthalmology, SUNY Downstate Medical Center, Albertson, NY; 2Ocular Oncology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA; 3Mount Sinai Doctors Brooklyn Heights, Brooklyn, NY; 4Clear View Medical P.C., Brooklyn, NY; 5Ophthalmology, Lions Eye Institute, Albany Medical College, Albany, NY; 6 Texas Oculoplastic Consultants, Austin, TX; 7 Ophthalmology, University of Iowa, Iowa City, IA 3500 — A0103 A clinical survey on subcutaneous triamcinolone acetonide eyelid injection for vernal keratoconjunctivitis. Tomoko Kawamura-Tsukahara, Y. SAEKI, J. Huang, E. Uchio. ophthalmology, Fukuoka University, Fukuoka, Japan 3501 — A0104 The withdrawal rate of oral and topical corticosteroids in vernal keratoconjunctivitis after topical immunosuppresants. Mika Shinoda, Y. Saeki, J. Huang, T. Tsukahara, E. Uchio. Fukuoka University, Fukuoka, Japan 3502 — A0105 Valproic acid promotes inflammation in conjunctival wound healing. Li-Fong Seet1, 2, L. Toh1, T. T. Wong1, 2. 1Ocular Therapeutics & Drug Delivery, Singapore Eye Research Institute, Singapore, Singapore; 2Research, Duke-NUS Medical School Singapore, Singapore, Singapore 3503 — A0106 Reducing Adenoviral Patient Infected Days (RAPID) Planning Study: Agreement between Clinician and AdenoPlusTM in the Diagnosis of Adenoviral Conjunctivitis. Mary Migneco1, M. O. Gordon1, A. T. Hartwick6, S. Johnson2, J. Harthan3, C. Morettin3, T. Than4, E. Shorter5, J. Huecker1. 1Ophthalmology, Washington University in St. Louis, St. Louis, MO; 2Optometry, Northeastern State University, Tahlequah, OK; 3 Optometry, Illinois College of Optometry, Chicago, IL; 4Optometry, University of Alabama, Birmingham, Birmingham, AL; 5Ophthalmology, Illinois Eye and Ear Infirmary, Chicago, IL; 6 Optometry, Ohio State University, Columbus, OH f 3504 — A0107 The Effect of Preserved Antiglaucoma Eye-drops on Goblet Cells and the Expression of Pro-inflammatory Markers. Javier Moreno-Montanes1, 3, G. Carracedo2, 3, E. Carnero1, 3, A. Bleau1, B. Fonseca2, 3, A. MartínezÁguila2, 3, J. J. Pintor2, 3, A. Guarnieri1, 3. 1Dep. of Ophthalmology, University of Navarra, Pamplona, Spain; 2Dep. of Biochemistry and Molecular Biology IV (Faculty of Optic and Optometry), University Complutense, Madrid, Spain; 3 OFTARED, RETICS Patología Ocular, Instituto Carlos III, Madrid, Spain *CR 3505 — A0108 Novel Characterization of Resident Plasmacytoid Dendritic Cells in the Conjunctiva. Aakash Gupta1, A. Jamali1, 2, M. J. Lopez1, 2, V. Sendra1, 2, D. L. Harris1, 2, H. Moein1, 2, Y. Seyed-Razavi1, 2, P. Hamrah2, 3. 1Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA; 2Ophthalmology, Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 3 Ophthalmology, Cornea Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 3506 — A0109 Immune Responses Induced by chlamydial Polymorphic Membrane Protein C formulated with probiotic Lactobacillus rhamnosus as an Adjuvant in Conjunctival Immunization. Aleksandra Inic-Kanada1, M. Stojanovic2, E. Marinkovic2, E. Stein1, I. Lukic2, S. Belij1, N. Schuerer1, J. Montanaro1, E. Ghasemian1, R. Djokic2, T. Barisani-Asenbauer1. 1OCUVAC - Laura Bassi, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; 2Department of Research and Development, Institute of Virology, Vaccines and Sera - TORLAK, Belgrade, Serbia 3507 — A0110 Rebamipide enhances the barrier function of human conjunctival epithelium. Yoshiyuki Satake, K. Higa, M. Dogru, T. Yamaguchi, J. Shimazaki. Ophthalmology, Tokyo Dental College, Ichikawa, Japan *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 242 Tuesday – Posters – 3508 – 3530 3508 — A0111 Time course of oxidative stress markers and inflammatory mediators in human conjunctival epithelial cells exposed to diesel exhaust particles. Romina M. Lasagni Vitar1, J. Tau2, A. Tesone2, N. Janezic1, A. Hvozda Arana1, C. Reides1, A. Berra2, S. M. Ferreira1, S. Llesuy1. 1 General and Inorganic Chemistry Division, IBIMOL (UBA-CONICET), Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina; 2Ocular Investigation Laboratory, Pathology Department, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina 3517 — A0120 Topical Low-Molecular-Weight Heparin-Taurocholate 7 Inhibits Corneal Neovascularization. Jae Yong Kim, M. Cheon, E. Kim, M. Kim, H. Tchah. Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea (the Republic of) 3509 — A0112 Oxidative stress measures in human tears and associations with conjunctival ultraviolet autofluorescence. Kristina Haworth1, H. L. Chandler2. 1Southern College of Optometry, Memphis, TN;2The Ohio State University College of Optometry, Columbus, OH 3519 — A0122 Blockade with Anti- Epithelial Membrane Protein-2 Antibody Decreases VEGF Expression in Human Corneal Limbal Epithelial Cells. Ann M. Chan, M. Wadehra, L. K. Gordon. University of California, Los Angeles, Los Angeles, CA *CR 3510 — A0113 Naringenin inhibits corneal neovascularization by anti-inflammatory and anti-oxidant mechanisms. Ana T. Oguido, A. M. Casella, W. Verri Junior, M. Hohmann, F. Ribeiro. Ophyhalmology, Univeridade Estadual de Londrina, Londrina, Brazil 3520 — A0123 PI3K/Akt/mTOR - A new target for corneal angiogenesis treatment? Javier A. Calles1, T. Sasore2, A. Lopez-Garcia1, B. N. Kennedy2, Y. Diebold1. 1IOBA - University of Valladolid, Valladolid, Spain; 2UCD SBBS & Conway Institute - University College Dublin, Dublin, Ireland 3512 — A0115 Potential modulatory role for MMP14 cleavage of VEGFR1 during angiogenesis. Kyuyeon Han, J. Chang, D. T. Azar. Ophthalmology and Visual Sciences, University of Illinois at Chicago, Brookfield, IL 3513 — A0116 miR-184 directly regulates corneal angiogenesis. Jong Kook, H. Peng, W. Yang, O. Volpert, R. M. Lavker. Feinberg School of Medicine, Northwestern University, Chicago, IL 3514 — A0117 Antiangiogenic Effect of a Novel Fusion Protein PFMC inhibiting NFKB pathway on Corneal Alkali Injury Rat Model. Juan P. Salica1, 2, A. Fichetti2, E. Chuluyan3, D. Guerrieri3, J. E. Gallo1, 2. 1Ophthalmology, Universidad Austral, Pilar, Argentina; 2Nanomedicine and Vision Group, Universidad Austral, ilarP, Argentina; 3 Pharmacology Department, Universidad de Buenos Aires, Capital Federal, Argentina 3515 — A0118 Anti-inflammatory and antifibrotic effects of novel peptide GQDGLAGPK in alkaline burns rabbit. Lee Yoon Jin, H. Lee, Y. Lee, J. Yang. Inje university Busan paik hospital, Busan, Korea (the Republic of) 3516 — A0119 Anti-Angiogenic Polymer Therapeutic for Corneal Neovascularization. Crystal Shin, X. Yuan, D. Marcano, L. Isenhart, K. Simmons, S. C. Pflugfelder, G. Acharya. Ophthalmology, Baylor College of Medicine, Houston, TX 3521 — A0124 The Neuropeptide Adrenomedullin as a New Target to Treat Corneal Angiogenesis. Deshea L. Harris1, A. Jamali1, A. Abbouda1, H. Moein1, P. Hamrah1, 2. 1 Ophthalmology, Tufts Medical Center, Boston, MA; 2New England Eye Center, Boston, MA 3522 — A0125 Regression Of Corneal Neovascularization Associated With Corneal Epithelial Defect After Treatment With Regenerating Agents ( Cacicol®). Olivia Esteban, M. A. del Buey, I. Perez, C. Almenara, M. Martinez, J. A. Cristóbal. Ophthalmolgy, Hospital, Zaragoza, Spain 3523 — A0126 Induced capillary remodelling in inflammatory ocular angiogenesis model. Anthony Mukwaya1, B. Bourghardt Peebo1, M. Xeroudaki1, Z. Ali2, L. Jensen2, 3, N. S. Lagali1. 1 Ophthalmology, Linkoping University, Linköping, Sweden; 2Department of Medical and Health Sciences, Division of Cardiovascular Medicine, Linköping University, Linkoping, Sweden; 3 Department of Microbiology, Tumor and Cell biology, the Karolinska Institute, Stockholm, Sweden *CR 3524 — A0127 Mechanistic studies for Vascular Endothelial Growth Factor-A and -B induced neuronal and endothelial cell growth. Victor H. Guaiquil, Y. Luo, J. Sarkar, M. Rosenblatt. Department of Ophthalmology and Visual Sciences, University of Illinois-Chicago, Chicago, IL 3526 — A0129 Background Data in a Rabbit Model of Suture-Induced Corneal Neovascularization (CNV). Mark Vezina1, C. Li1, M. Bussieres2. 1Ocular and Neuroscience, Charles River, Senneville, QC, Canada; 2V & O Services, St. Lazare, QC, Canada *CR 3527 — A0130 DELTA Scoring System: A Novel method for clinical grading of corneal neovascularization. SUNEEL Gupta1, 2, M. K. Fink1, 4, P. R. Sinha1, 2, R. R. Mohan1, 3. 1Harry S. Truman Memorial Veteran Hospital, Columbia, MO; 2Veterinary Medicine & Surgery, University of Missouri, Columbia, MO; 3Veterinary Medicine & Surgery, Biomedical Sciences, Veterinary Pathology and Mason Eye Institute, University of Missouri, Columbia, MO; 4Veterinary Medicine & Surgery and Veterinary Pathology, University of Missouri, Columbia, MO 3528 — A0131 Pro-angiogenic Factors are Elevated in the Cornea of Patients undergoing Transplant for Conditions Associated with Infection Compared to Non-infectious or Inflammation Alone. Jennifer L. Wu1, J. K. Jinkins1, D. J. Carr1, 2. 1Ophthalmology, Dean McGee Eye Institute, Oklahoma City, OK; 2 Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 3529 — A0132 Macrophages, angiopoietin 2, and corneal neovascularization: translational implications. Giulio Ferrari1, C. giacomini1, F. Bignami1, D. moi1, A. ranghetti1, C. doglioni1, L. naldini1, P. Rama1, R. mazzieri2. 1San Raffaele Scientific Institute, Milan, Italy; 2Diamantina Institute Faculty of Medicine and Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia 3530 — A0133 Comparison of Two Treatments for Corneal Neovascularization One-Year Follow-Up: Photodynamic therapy with Verteporfin vs Photodynamic Therapy combined with Subconjunctival Ranibizumab. Alexandra Pena1, A. Navas2, E. O. Graue-Hernandez2, G. de Wit3, R. Bolanos3, 1. 1Ophthalmology, Regional Hospital Lic. Adolfo Lopez Mateos Issste, Mexico City, Mexico;2Cataract and refractive surgery, Institute of Ophthalmology Conde de Valenciana, Mexico, Mexico; 3Cornea and refractive surgery, Association to prevent blindness in Mexico, Mexico, Mexico f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 243 Tuesday Posters 11:00 am – 12:45 pm 3511 — A0114 MMP12 Inhibits Corneal Neovascularization Through Regulation of CCL2. Matilda F. Chan, M. Wolf, S. M. Clay. Ophthalmology, Univ of California-San Francisco, San Francisco, CA 3518 — A0121 Topical Fosaprepitant Treatment in Established Corneal Neovascularization. Fabio Bignami, A. Lorusso, P. Rama, G. Ferrari. Cornea and Ocular Surface Disease Unit, Eye Repair Lab, IRCCS San Raffaele Scientific Institute, Milan, Italy *CR 3525 — A0128 Relation of Tenascin X and VEGF in the corneal cauterization model. Takayoshi Sumioka1, Y. Okada1, O. Yamanaka1, Y. Nidegawa1, M. Miyajima2, K. Matsumoto3, S. Saika1. 1Ophthalmology, Wakayama Medical University, Wakayama, Japan; 2Animal center, Wakayama Medical University, Wakayama, Japan; 3 Interdisciplinary Center for Science Research, Department of Biosignaling and Radioisotope Experiment, Shimane University, Shimane, Japan 3531 – 3551 – Tuesday – Posters 3531 — A0134 Effects of Vascular Endothelial Growth Factor-A and -B on angiogenesis and nerve regeneration of the cornea. qiang zhou, V. H. Guaiquil, Y. Luo, M. Sun, M. Rosenblatt. Ophthalmology & Visual Science, University of Illinois at Chicago, Chicago, IL 3532 — A0135 Angiopoietin-like 3 (ANGPTL3) Does not Induce Corneal Neovascularization (CoNV) after Intrastromal Injection of Plasmid DNA Encoding ANGPTL3 in Mice. Duo Sun, H. Li, Y. Liu, P. Stevis, V. Gusarova, C. Romano, J. Cao. Regeneron Pharmaceuticals, Inc., Tarrytown, NY *CR Tuesday Posters 11:00 am – 12:45 pm 3533 — A0136 Maspin regulates human lymph endothelial cell tube formation in a biphasic manner. Sally S. Twining, D. Warejcka, X. Moua. Biochemistry and Ophthalmology, Medical College of Wisconsin, Milwaukee, WI 3539 — A0142 Comparison of Surgical Methods and the Use of Mitomycin-C for the Treatment of Recurrent Pterygium. Hyunjoo J. Lee, Y. J. Kim. Ophthalmology, Boston University School of Medicine, Boston, MA 3545 — A0243 Decreased Intraocular Pressure after Tarsal Strip for Ectropion Repair. Chad Kaplan, T. Nees, L. Ghadiali, D. Blumberg, L. AlAswad, G. A. Cioffi, C. De Moraes, B. Winn, J. M. Liebmann. Ophthalmology, Columbia University, New York, NY Exhibit/Poster Hall A0238-A0271 3546 — A0244 Change in biomechanical parameters analyzed with the Corvis ST following trabeculectomy. Karin R. Pillunat, E. Spoerl, L. E. Pillunat. Ophthalmology, Univ Clinic Carl Gustav Carus Dresden, Dresden, Germany f Tuesday, May 03, 2016 11:00 AM-12:45 PM Glaucoma 339 Glaucoma Biomechanics Moderators: Massimo A. Fazio and Rafael Grytz 3534 — A0137 VEGF-C trap to block lymphangiogenesis after corneal transplantation. Susie Choi. Ophthalmology, University of Utah, Salt Lake City, UT 3540 — A0238 Aqueous Humor Flow in the Posterior Chamber of the Eye in the Case of Iridotomy. Jennifer H. Tweedy1, M. Dvoriashyna2, R. Repetto2. 1Department of Bioengineering, Imperial College London, London, United Kingdom; 2Department of Civil, Chemical and Environmental Engineering, University of Genoa, Genoa, Italy *CR 3535 — A0138 Overexpression of monocyte-derived Wnt5a promotes corneal lymphangiogenesis. Roberto Sessa1, P. Padmanaban1, S. Wan1, S. Shen1, A. Smith3, T. Yamaguchi2, R. A. Lang3, L. Chen1.1Optometry, UC Berkeley, Berkekely, CA; 2Center for Cancer Research, National Institutes of Health, Frederick, MD; 3Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 3541 — A0239 Regionally Discrete Aqueous Humor Outflow Quantification using Fluorescein Canalograms. Eric N. Brown1, R. Loewen2, 3, P. Sengupta2, 3, J. S. Schuman2, 3, I. A. Sigal2, 3, N. A. Loewen2, 3.1Department of Ophthalmology, Vanderbilt University, Nashville, TN; 2Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 3The Louis J Fox Center for Vision Restoration, University of Pittsburgh, Pittsburgh, PA 3536 — A0139 RNA sequencing-based comparative transcriptome analysis of nasaltemporal difference of corneal lymphangiogenesis. guangyu li1, 2, Y. Wen1, 2, L. zhang1, 2, L. Chen1, 2. 1 Vision Science Graduate Group, University of California, Berkeley, Berkeley, CA; 2Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, CA 3542 — A0240 Treatment with AICAR decreases intraocular pressure in perfused ex vivo human anterior segments. Ayan Chatterjee1, G. Villarreal3, D. Oh2, D. J. Rhee2. 1Wills Eye Hospital, Philadelphia, PA; 2Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH; 3Wilmer Eye Institute, Baltimore, MD *CR 3537 — A0140 Specific Inhibition of Inflammatory Corneal Lymphangiogenesis by Topical Inhibition of VEGF-C and -D. Felix Bock1, A. Schneider1, M. Baldwin2, C. Cursiefen1. 1 Ophthalmology, University of Cologne, Cologne, Germany; 2Opthea Pty Ltd/ Circadian Technologies Limited, South Yarra, VIC, Australia *CR 3538 — A0141 Tracking Changes in Corneal Tomography After Pterygium Excision to Aid Planning Future Refractive Surgery. Michael Korchak1, S. L. Cremers2, J. Ha2, J. Koppinger1, 3, J. A. Martinez2, 1. 1Ophthalmology, Medstar Georgetown/Washington Hospital Center, Washington, DC; 2Visionary Ophthalmology, Rockville, MD; 3Georgetown University School of Medicine, Washington, DC 3543 — A0241 Estimating human trabecular meshwork stiffness by numerical modeling and advanced OCT imaging. Ke Wang1, M. A. Johnstone2, C. Xin3, S. Padilla2, R. K. Wang3, C. R. Ethier1.1Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 2 Ophthalmology, University of Washington, Seattle, WA; 3Bioengineering, University of Washington, Seattle, WA 3544 — A0242 Bidirectional interactions between trabecular meshwork cells and their extracellular matrix in the presence of dexamethasone. Vijaykrishna Raghunathan2, C. J. Murphy1, 2, P. Russell2.1Ophthalmology & Vision Science, University of California Davis, Davis, CA; 2 Surgical & Radiological Sciences, University of California Davis, Davis, CA 3547 — A0245 Assessment of residual effects due to topical medication on corneal stiffness in primary open angle glaucoma. Sushma Tejwani1, M. Francis2, S. Dinakaran1, R. Mehta1, R. shetty2, A. Sinha Roy2. 1Glaucoma, Narayana Nethralaya, Bangalore, India; 2Narayana Nethralaya, Bangalore, India *CR 3548 — A0246 Estimating diurnal changes in ocular dimension fluctuations using the Triggerfish Contact Lens Sensor and assessing its potential in 24-hour monitoring of heart rate variability in glaucoma patients. Monika E. Danielewska1, M. Rekas2, A. Byszewska2, J. Wierzbowska2, K. Petz2, D. Iskander1. 1Department of Biomedical Engineering, Wroclaw University of Technology, Wroclaw, Poland; 2Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland 3549 — A0247 Corneal Peak Distance (PD) is Higher in Primary Angle Closure Glaucoma (PACG) Subjects than in Normal and Primary Open Angle Glaucoma (POAG) Subjects. Owen Png1, M. Baskaran2, 3, T. Tun2, S. Sharma2, Y. Tham2, C. Cheng2, 3, T. Aung2, 3, M. J. Girard4. 1Duke-NUS Graduate Medical School, Singapore, Singapore; 2 Singapore Eye Research Institute, Singapore, Singapore; 3Singapore National Eye Centre, Singapore, Singapore; 4National University of Singapore, Singapore, Singapore 3550 — A0248 Correlating corneal biomechanical properties with lamina cribosa in healthy subjects. Francisco Pérez Bartolomé, J. Martínez de la Casa, I. Camacho Bosca, F. Sáenz Francés, J. García Feijoó. Ophthalmology, Hospital Clínico San Carlos, Madrid, Spain 3551 — A0249 Ocular rigidity: a novel noninvasive clinical method. Diane N. Sayah2, 1, J. Mazzaferri2, L. Beaton2, F. Lalonde2, 3, M. Hidalgo2, 4, S. Costantino2, 5, M. R. Lesk2, 5. 1School of Optometry, University of Montreal, Roxboro, QC, Canada; 2Ophthalmology, MaisonneuveRosemont Hospital Research Center, Montreal, QC, Canada; 3Biomedical Sciences, University of Montreal, Montreal, QC, Canada; 4Institut National de la Recherche Scientifique, Varennes, QC, Canada; 5Ophthalmology, University of Montreal, Montreal, QC, Canada *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 244 Tuesday – Posters – 3552 – 3571 3552 — A0250 The Relationships between Corneal Elasticity Measured by Surface Wave Elastography and other Ocular Variables. Arash Kazemi1, J. W. McLaren1, C. M. Pruet1, S. Lin2, 1, X. Zhang1, A. J. Sit1. 1Ophthalmology, Mayo Clinic Rochester, Rochester, MN; 2Ophthalmology, Wills Eye Hospital, Philadelphia, PA 3553 — A0251 Relationships between Axial Length and Ocular Biomechanical Properties. Christopher M. Pruet, A. Kazemi, X. Zhang, J. W. McLaren, A. J. Sit. Ophthalmology, Mayo Clinic, Rochester, MN*CR 3554 — A0252 Progression in infantile glaucoma: comparing structural and biometric changes. Kara M. Cavuoto, K. Jaben, T. C. Chang. Univ of Miami Sch of Medicine, Miami, FL 3556 — A0254 Shape Changes of the Anterior Lamina Cribrosa in Healthy and Glaucoma Eyes following Acute Intraocular Pressure Elevations. Tin A. Tun1, O. Png2, B. Mani1, 2, S. Sharma1, H. M. Htoon1, 2, S. Thakku1, C. Cheng1, 2, N. G. Strouthidis3, 1, T. Aung1, 2, M. J. Girard1. 1Singapore Eye Research Institute, Singapore, Singapore; 2 Duke-NUS Graduate Medical School, Singapore, Singapore; 3NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom 3557 — A0255 A Novel Virtual Fields Method to Measure the Biomechanical Properties of Human Optic Nerve Head Tissues. Liang Zhang1, 2, M. Baskaran3, 4, T. Aung3, 5, N. Strouthidis3, 6, M. J. Girard2, 3. 1NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; 2Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore; 3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; 4Eye-ACP, Office of Clinical, Academic and Faculty Affairs, Duke-NUS Medical School, Singapore, Singapore; 5Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; 6NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom 3559 — A0257 Finite element analysis of pressure effect on biomechanical response of the optic nerve head in glaucoma. Yingyan Mao. Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing, China 3560 — A0258 Probabilistic Modeling of Intracranial Pressure Effects on Optic Nerve Biomechanics. C R. Ethier1, A. J. Feola1, J. Raykin1, J. G. Myers2, E. S. Nelson2, B. C. Samuels3. 1 Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 2NASA Glenn Research Center, Cleveland, OH; 3Ophthalmology, UAB, Birmingham, AL 3561 — A0259 In vivo evaluation of optic disc changes and anterior lamina cribrosa displacement after acute cerebrospinal fluid pressure reduction in healthy humans. Muriel Poli1, 3, A. M. Bron4, E. Sellem2, P. Denis3, C. Burillon3. 1Centre Ophtalmologique Pole Vision Val d’Ouest, Lyon, Dominica; 2Centre Ophtalmologique Kleber, Lyon, France; 3Centre Hospitalier Universitaire, Lyon, France; 4Centre Hospitalier Universitaire, Dijon, France 3562 — A0260 Asymmetry in anterior lamina cribrosa surface tilting may contribute to retinal nerve fiber layer defect in myopia. Eun Jung Lee, J. Han, C. Kee. Ophthalmology, Samsung Medical Center, Sungkyunkwan university, Seoul, Korea (the Republic of) 3563 — A0261 Optic Nerve (ON) Sheath Traction on the Temporal Peripapillary Sclera in Adduction: Biomechanical Evidence for a Role in Normal Tension Glaucoma (NTG). Andrew Shin, J. Park, J. L. Demer. Ophthalmology, Stein Eye Institute, UCLA, Los Angeles, CA 3564 — A0262 Regional Variations in the Strains of the Human Optic Nerve Head. Dan Midgett2, T. D. Nguyen2, H. A. Quigley1, M. Pease1, C. Franck3, M. Patel3. 1Ophthalmology, Johns Hopkins, Baltimore, MD; 2Mechanical Engineering, Johns Hopkins University, Baltimore, MD; 3 Engineering, Brown University, Providence, RI 3565 — A0263 In-vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of The Lamina Cribrosa. Huong Tran1, 2, A. P. Voorhees1, B. Wang1, 2, N. Jan1, 2, E. Tyler-Kabara3, L. Kagemann1, 2, H. Ishikawa1, 2, J. S. Schuman1, 2, M. A. Smith1, 2, G. Wollstein1, I. A. Sigal1, 2. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; 3Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA *CR 3566 — A0264 Novel method reveals heterogeneous micro-scale response of sclera collagen bundles to homogeneous macro-scale stretch. Ning-Jiun Jan1, 2, M. Iasella2, M. Lester2, D. Hu1, K. L. Lathrop1, A. P. Voorhees1, H. Tran1, 2, G. Wollstein1, J. S. Schuman1, 2, I. A. Sigal1, 2. 1 Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, PA; 2Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA *CR 3567 — A0265 Collagen crimp waviness, tortuosity and period have different patterns around the eye. Danielle Hu1, N. Jan1, 2, M. Iasella1, 2, H. Tran1, 2, Y. Ling1, J. S. Schuman1, 2, A. Judisch1, A. P. Voorhees1, G. Wollstein1, 2, I. A. Sigal1, 2. 1Opthalmology, University of Pittsburgh, Pittsburgh, PA; 2Bioengineering, University of Pittsburgh, Pittsburgh, PA *CR 3568 — A0266 ONH Deformation in Porcine Eyes Using Ultrasound Speckle Tracking. Elias Pavlatos, X. Pan, R. T. Hart, P. Weber, J. Liu. The Ohio State University, Columbus, OH 3569 — A0267 Polarization Sensitive Optical Coherence Tomography (PSOCT) Demonstrates Strain Dependent Birefringence in Ocular Tissues. Joseph Park, A. Shin, J. L. Demer. Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 3570 — A0268 Finite Element (FE) Modeling of Optic Nerve Head (ONH) Biomechanics in a Rat Model of Glaucoma. Stephen A. Schwaner1, M. Pazos4, H. Yang2, C. F. Burgoyne2, C. R. Ethier3, 1.1Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA; 2Ophthalmology, Devers Eye Institute, Portland, OR; 3Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 4Departamento del Luminotecnia, Hospital Esperanza. Parc de Salut Mar., Barcelona, Spain 3571 — A0269 Effects of intracranial and intraocular pressure modification on the optic nerve of young and old rats. Da Zhao, C. T. Nguyen, Z. He, A. J. Vingrys, B. V. Bui. Optometry and Vision Sciences, University of Melbourne, Melbourne, VIC, Australia f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 245 Tuesday Posters 11:00 am – 12:45 pm 3555 — A0253 Racioethnic Differences in the Biomechanical Environment of the Lamina Cribrosa. Jonathan P. Vande Geest1, 5, S. Ram3, S. J. Howerton1, F. Danford1, U. Utzinger4, 5, J. J. Rodriguez3, 2.1Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ; 2Graduate Interdisciplinary Program of Biomedical Engineering, The University of Arizona, Tucson, AZ; 3Electrical and Computer Engineering, The University of Arizona, Tucson, AZ; 4BIO5 Institute, The University of Arizona, Tucson, AZ; 5Biomedical Engineering, The University of Arizona, Tucson, AZ 3558 — A0256 Influence of tissue viscoelasticity on the optic nerve head perfusion: a mathematical model. Daniele Prada1, R. Sacco3, B. Cockburn4, L. Bociu5, J. Webster6, B. A. Siesky2, A. Harris2, G. Guidoboni1, 2. 1Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN; 2Ophthalmology, Indiana University, Indianapolis, IN; 3Mathematics, Politecnico di Milano, Milano, Italy; 4Mathematics, University of Minnesota, Minneapolis, MN; 5 Mathematics, North Carolina State University, Raleigh, NC; 6Mathematics, College of Charleston, Charleston, SC *CR 3572 – 3589 – Tuesday – Posters 3572 — A0270 A Pilot Study for the Initial Validation of a Tree Shrew Model of Glaucoma. Brian C. Samuels, C. A. Girkin, L. Hethcox, J. C. Downs, W. Zhan. Ophthalmology, University of Alabama at Birmingham, Birmingham, AL 3573 — A0271 Generation of a viable, fertile Matrix-Gla (Mgp)-floxed mouse by CRISPR/ CAS9 technology. Relevance for the creation of stiffness mouse models of glaucoma. Terete Borras1, 2, K. Pandya3, 4, D. Cowley3, R. Elliott1. 1 Ophthalmology, Universsity of North Carolina at Chapel Hill, Chapel Hill, NC; 2Gene Therapy Center, Chapel Hill, NC; 3University of North Carolina at Chapel Hill, Chapel Hill, NC; 4 Transviragen, Raleigh, NC Exhibit/Poster Hall B0014-B0027 Tuesday, May 03, 2016 11:00 AM-12:45 PM Visual Neuroscience / Low Vision 340 Ganglion Cells and Beyond Tuesday Posters 11:00 am – 12:45 pm Moderator: Michael B. Manookin 3574 — B0014 Morphological characteristics of retinal ganglion cells in the giant panda (Ailuropoda melanoleuca) retina. Wenyao Wang1, C. Wang2, Y. Zhou1, R. Wei2, Y. Nan1, L. Deng2, J. Gao1, C. Zhang3, D. Li2, M. Pu1. 1Anatomy/ Embryology, Peking University, Beijing, China; 2 China Conservation and Research Center for the Giant Panda (CCRCGP), Chengdu, China; 3Peiking University Third Hospital, Beijing, China 3575 — B0015 Morphological and physiological diversity of retinal ganglion cells in the vertebrate retina. Ji-Jie Pang, F. Gao, S. M. Wu. Ophthalmology, Baylor College of Medicine, Houston, TX 3576 — B0016 Properties of novel types of transient On ganglion cells in the rabbit retina. Ye Long, S. L. Mills. Univ of Texas Health Science Center at Houston, Houston, TX 3577 — B0017 Electrical and Visual STA Types Correlate in Mouse Retina. Sudarshan Sekhar, A. Jalligampala, E. Zrenner, D. L. Rathbun. Experimental Retinal Prosthetics Group, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany *CR 3578 — B0018 In search of the color-coding ganglion cell. Michael B. Manookin, J. A. Kuchenbecker, M. Neitz, J. Neitz. Ophthalmology, University of Washington, Seattle, WA 3579 — B0019 TRPV4 Augments The Excitability Of Mouse Retinal Ganglion Cells. Oleg Yarishkin1, M. B. Kozhemyakin1, D. A. Ryskamp1, D. Krizaj1, 2. 1Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, John A. Moran Eye Institute, Salt Lake City, UT; 2Department of Neurobiology and Anatomy, University of Utah School of Medicine, John A. Moran Eye Institute, Salt Lake City, UT 3580 — B0020 Spatial extent of inputs to primate ganglion cells in natural viewing conditions. Nora Brackbill1, N. Shah2, G. A. Goetz3, A. Tikidji-Hamburyan3, C. Rhoades4, A. Sher5, A. Litke5, E. Chichilnisky3. 1Physics, Stanford University, Stanford, CA; 2Electrical Engineering, Stanford University, Stanford, CA; 3Neurosurgery, Ophthalmology, and Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA; 4 Bioengineering, Stanford University, Stanford, CA; 5 Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, Santa Cruz, CA 3581 — B0021 Comparing receptive field center size with dendritic field size of ganglion cells in salamander retinas. Jing Wang, R. L. Seilheimer, J. Sabharwal, S. M. Wu. Ophthalmology, Baylor College of Medicine, Houston, TX 3582 — B0022 Determining the contribution of specific retinal circuits to mouse retinal ganglion cell space-time tuning. Jasdeep Sabharwal1, 2, R. L. Seilheimer1, 2, J. Wang1, C. S. Cowan3, S. M. Wu1.1Ophthalmology, Baylor College of Medicine, Houston, TX; 2MSTP, Baylor College of Medicine, Houston, TX; 3Neurobiology, Friedrich Miescher Institute for biomedical research, Basel, Sweden 3583 — B0023 Sodium channel band expression in the AIS: fundamentals of activation threshold. Alex E. Hadjinicolaou2, 1, P. Werginz3, V. Raghuram2, 1, F. Rattay3, S. I. Fried2, 1. 1Department of Neurosurgery, Harvard Medical School, Boston, MA; 2Vision Research Laboratory, Boston VA Medical Center, Boston, MA; 3Institute for Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria 3584 — B0024 Antipsychotic drugs improve visual responses of ganglion cells in a rat model of retinitis pigmentosa. Ralph Jensen. VA Boston Healthcare System, Boston, MA 3585 — B0025 Effect of brain state on visual stimulus detectability in lateral geniculate nucleus of anaesthetized marmosets. Paul R. Martin1, 2, A. N. Pietersen1, 2, N. Zeater1, 2, S. K. Cheong3, S. G. Solomon4, 5. 1Save Sight Institute, University of Sydney, Sydney, NSW, Australia; 2 Australian Research Council Centre of Excellence for Integrative Brain Function, Sydney, NSW, Australia; 3Center for Visual Science, University of Rochester, Rochester, NY; 4School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; 5Experimental Psychology, University College London, London, United Kingdom 3586 — B0026 Selective vulnerability of specific retinal ganglion cell subtypes in a mouse model of ocular hypertension. Yvonne Ou1, R. Jo1, E. M. Ullian1, R. O. Wong2, L. Della Santina3. 1 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA; 2 Department of Biological Structure, University of Washington, Seattle, WA; 3Department of Pharmacy, University of Pisa, Pisa, Italy 3587 — B0027 Large scale matching of anatomy and function of retinal ganglion cells. Filippo Pisano1, E. Zampaglione2, N. McAlinden1, J. Roebber2, M. D. Dawson1, K. Mathieson1, A. Sher2. 1 Dept.of Physics-University of Strathclyde, Institute of Photonics, Glasgow, United Kingdom; 2Santa Cruz Institute for Particle Physics, University of California Santa Cruz, Santa Cruz, CA Exhibit/Poster Hall B0028-B0045 Tuesday, May 03, 2016 11:00 AM-12:45 PM Visual Neuroscience 341 Clinical electrophysiology Moderator: Jan J. Kremers 3588 — B0028 Effect of varying skin surface electrode position on electroretinogram responses recorded using a handheld stimulating and recording system. Angharad E. Hobby1, 2, D. Kozareva2, 3, E. H. Yonova2, 3, I. T. Hossain2, M. Katta2, B. Huntjens1, A. Binns1, C. J. Hammond2, 3, O. A. Mahroo2, 4. 1Division of Optometry & Visual Sciences, City University London, London, United Kingdom; 2Department of Ophthalmology, King’s College London, St Thomas’ Hospital Campus, London, United Kingdom; 3Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ Hospital Campus, London, United Kingdom; 4Moorfields Eye Hospital, London, United Kingdom 3589 — B0029 The heritability of implicit times of photopic flicker electroretinogram responses recorded using a handheld recording system with skin electrodes. Xining He1, 2, E. H. Yonova1, 4, D. Kozareva1, 4, M. Katta1, C. J. Hammond1, 4, O. A. Mahroo1, 3. 1Department of Ophthalmology, King’s College London, St Thomas’ Hospital Campus, London, United Kingdom; 2Moorfields Eye Hospital, 162 City Road, London, United Kingdom; 3 Institute of Ophthalmology, University College of London, London, United Kingdom; 4Department of Twin Research and Genetic Epidemiology, King’s College of London, St Thomas’ Hospital Campus, London, United Kingdom The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 246 Tuesday – Posters – 3590 – 3610 3590 — B0030 Altering the amplitude of photopic negative responses recorded using the RETeval visual electrodiagnostic system for patients with glaucoma. Muneyoshi Kaneko1, S. Machida2, S. Sakamoto3, N. Satou3, D. Kurosaka4. 1Ophthalmology, Morioka Municipal Hospital, Morioka, Japan; 2Ophthalmology, Dokkyo Medical University, Koshigaya, Japan; 3 Ophthalmology, Sakamoto Eye Clinic, Miyako, Japan;4Ophthalmology, Iwate Medical University, Morioka, Japan 3591 — B0031 Multifocal electroretinography to evaluate retinal function in the setting of a multicenter clinical trial. Silvia N. Simao. CORC, AIBILI, Coimbra, Portugal f 3592 — B0032 Screening test characteristics of a novel hand-held ERG device in detection of referable diabetic retinopathy. Taras V. Litvin1, 2, G. H. Bresnick1, 3, G. Y. Ozawa1, K. Kanai1, J. A. Cuadros1, 3. 1School of Optometry, UC Berkeley, Berkeley, CA; 2Vision Science Graduate Group, UC Berkeley, Berkeley, CA; 3EyePACS, LLC, San Jose, CA *CR 3594 — B0034 Towards rapid assessment of retinal function in clinic: comparison of implicit times of photopic flicker electroretinogram responses recorded using a conventional and a portable system in patients with Birdshot chorioretinopathy. Omar A. Mahroo1, 2, A. E. Hobby1, 3, E. H. Yonova1, D. Kozareva1, I. T. Hossain1, M. Katta1, C. J. Hammond1, M. R. Stanford1. 1King’s College London, London, United Kingdom; 2UCL Institute of Ophthalmology, London, United Kingdom; 3City University, London, United Kingdom 3595 — B0035 Super-normal flicker ERG amplitudes in eyes with non-ischemic CRVO. Ryohei Miyata2, K. Kato2, Y. Matsui1, M. Kozawa2, H. Matsubara2, M. Sugimoto2, M. Kondo2. 1 Ophthalmology, Okanami General Hospital, Iga, Japan; 2Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan *CR 3597 — B0037 Multifocal electroretinogram responses in former preterms with and without history of retinopathy of prematurity (ROP). Pablo Altschwager1, 2, R. M. Hansen1, 2, A. Moskowitz1, 2, J. Bush1, A. B. Fulton1, 2. 1Boston Children’s Hospital, Boston, MA; 2Harvard Medical School, Boston, MA 3598 — B0038 Repeated Flicker electroretinograms recordings before and after intravitreal ranibizumab injection in eyes with central retinal vein occlusion. Shunsuke Yasuda, S. Ueno, S. Kachi, T. Kominami, A. Nakanishi, C. Piao, H. Terasaki. Ophthalmology, Nagoya Univ Graduate Sch of Med, Nagoya, Japan 3599 — B0039 Intravitreal Bevacizumab and Laser Treatment for Type 1 Retinopathy of Prematurity (ROP): Electroretinographic Responses to Full-Field Stimuli. Domenico Lepore1, E. A. Swanson2, L. Orazi1, F. Molle1, A. Baldascino1, J. D. Akula2, R. M. Hansen2, A. B. Fulton2. 1Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy; 2Ophthalmology, Boston Children’s Hospital, Boston, MA *CR, f 3600 — B0040 Multimodal investigation on inherited retinal dystrophies: an objective approach to describe disease presentation and progression. Lucia Ziccardi1, D. Giannini1, G. Lombardo2, 3, S. serrao1, M. Varano1, A. Bruson4, M. Bertelli4, M. Lombardo1. 1Ophthalmology, IRCCS “G.B. Bietti” Eye Foundation, Rome, Italy; 2Ist. per i processi Chimico-FIsici CNR-IPCF, Consiglio Nazionale delle Ricerche, Messina, Italy; 3Vision Engineering Italy, srl, Rome, Italy; 4MAGI Human Medical Genetics Institute, Rovereto, Italy *CR 3601 — B0041 Function of the visual pathway in preterm children at school age. Hanna M. Akerblom1, S. Andreasson2. 1Neurosience, Ophthalmology, Uppsala University, Uppsala, Sweden; 2Ophthalmology, Lund University, Lund, Sweden 3602 — B0042 Electrophysiology and anatomy of the retina in albinism: is there a correlation with visual acuity? Arlene V. Drack1, Z. hu1, T. Kehoe1, A. Kemerley2, 3, M. Helms1, S. Bhattarai1, W. Pfeifer1.1Ophthalmology, Univ of Iowa Hospitals and Clinics, Iowa City, IA; 2University of Iowa, Iowa City, IA; 3University of Des Moines, Des Moines, IA *CR 3603 — B0043 Longitudinal study of retinal and optic nerve function in patients with multiple sclerosis - a baseline report. Christina Gerth-Kahlert, K. Landau, J. V. Hanson. University of Zurich, Zurich, Switzerland *CR 3604 — B0044 Visual Evoked Potential (VEP) Testing and Craniofacial Synostosis (CS): Results in 67 Patients. Simone L. Li, R. W. Hertle, W. Lawhon, N. Hanna, A. Patel, A. Murthy, T. Chen. Ophthalmology, Akron Children’s Hospital, Akron, OH 3605 — B0045 Repeatability And Reproducibility Of Short-Duration Transient Visual Evoked Potentials In Normal Older Adults. Rick Trevino, C. Majcher, A. Henry, U. Bui, W. E. Sponsel. Rosenberg School of Optometry, University of the Incarnate Word, San Antonio, TX Exhibit/Poster Hall B0153-B0163a Tuesday, May 03, 2016 11:00 AM-12:45 PM Anatomy and Pathology/Oncology 342 Genes and proteins in myopia: Humans and Animal models 3606 — B0153 Whole Exome Sequencing Identifies a Rare Variant Co-segregating with High Myopia. Bethany A. Kloss1, S. W. Tompson1, K. Whisenhunt1, S. J. Huang1, T. Rosenberg2, T. L. Young1.1University of Wisconsin, Madison, WI; 2 National Eye Clinic, Kennedy Center, Glostrup, Denmark 3607 — B0154 Replication of known loci and suggestive linkage for Familial Myopia on three chromosomes in African-Americans. Joan E. Bailey-Wilson1, A. M. Musolf1, C. L. Simpson1, L. Portas2, 1, F. Murgia2, 1, Q. Li1, D. Stambolian3. 1 Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD; 2Institute of Population Genetics, Sassari, Italy; 3Ophthalmology, University of Pennsylvania, Philadelphia, PA 3608 — B0155 Genome-wide DNA methylation analysis and epigenetic variations associated with High-Grade Myopia. Kereena Chukka. Department of Biotechnology, Acharya Nagarjuna University, Guntur, India 3609 — B0156 Mfrp regulates ocular growth in mice and interacts with Prss56. Mark P. Krebs, W. Hicks, P. M. Nishina. The Jackson Laboratory, Bar Harbor, ME 3610 — B0157 lrp2-/- zebrafish eyes show modulation of multiple genetic pathways, including Bmp signaling, that cause myopia. Brian Link, A. L. Pavlovich, J. Bader, J. C. Besharse, R. F. Collery. Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 247 Tuesday Posters 11:00 am – 12:45 pm 3593 — B0033 Evaluation of the RETeval 30 Hz Flicker ERG in the Assessment of Diabetic Patients. Ange-Lynca Kantungane2, 1, V. Popovic1, M. Faris1, 2, J. Hamilton2, 1, S. Coupland2, 1. 1 ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada; 2ophthalmology, Ottawa Hospital Research Institute, Ottawa, ON, Canada *CR 3596 — B0036 The light adaptation phenomenon in human: receptoral and postreceptoral involvement. Alódia Brasil5, 1, T. I. Tsai1, G. S. Souza5, 2, A. M. Herculano5, D. F. Ventura3, L. L. Silveira5, 6, J. J. Kremers1, 4. 1 Ophthalmology, Friedrich-Alexander-UniversitatErlangen-Nurnberg, Erlangen, Germany; 2Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Brazil; 3Experimental Psychology, University of São Paulo, São Paulo, Brazil; 4 Anatomy II, Friedrich-Alexander-UniversitatErlangen-Nurnberg, Erlangen, Germany; 5 Biological Sciences Institute, Federal University of Para, Belém, Brazil; 6Ceuma University, Sao Luis, Brazil 3611 – 3630 – Tuesday – Posters 3611 — B0158 Systematic integrated comparison of omics studies highlights similarities in the biological basis of animal and human myopia. Nina Riddell, L. Giummarra, S. G. Crewther. Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia 3612 — B0159 Proteomic analysis implicates energy metabolism in recovery from FDM. Loretta Giummarra, N. Riddell, S. G. Crewther. Psychology & Public Health, La Trobe University, Melbourne, VIC, Australia 3613 — B0160 Functional contribution by PPARα expression to emmetropization in mice. Chanyi Lu, J. Ke, J. Yan, M. Zheng, J. Qu, X. Zhou. Wenzhou Medical University, School of Optometry and Ophthalmology | Eye Hospital, Wenzhou, China 3614 — B0161 Declines in FP receptor-linked signaling may contribute to form-deprived myopic development in guinea pigs. jinglei yang. Wenzhou Medical University, Wenzhou, China Tuesday Posters 11:00 am – 12:45 pm 3615 — B0162 Reduced mRNA expression of apolipoproteinD is associated with recovery from myopia in guinea pig retina. Lena D. Fuchs1, M. P. Feldkaemper2, S. A. McFadden1. 1 Behavioural Sciences, University of Newcastle, Australia, Newcastle, NSW, Australia; 2Section of Neurobiology of the Eye, Institute for Ophthalmic Research, Tuebingen, Germany 3616 — B0163 Eliminating the Master Clock Gene in the Murine Retina Produces Myopia. Duk Cheon Lee5, R. Chakraborty1, 5, P. Iuvone1, 2, R. A. Stone3, M. T. Pardue5, 4. 1Ophthalmology, Emory University, Atlanta, GA; 2Pharmacology, Emory University, Atlanta, GA; 3Ophthalmology, University of Pennsylvania, Philadelphia, PA; 4 Biomedical Engineering, Georgia Institue of Technology / Emory University, Atlanta, GA;5Center for Visual and Neurocognitive Rehabilitation, Atlanta VA center, Decatur, GA 3616a — B0163a Alkaline Phosphatase Enriched Exosomes as Guidance Cues in the Developing Avian Optic Chiasm. Daniel Elefant1, I. Hernandez-Morato1, J. Kumaratilake2, S. C. Sharma1, S. A. Newman1. 1New York Medical College, Valhalla, NY; 2University of Adelaide, Australia, Adelaide, SA, Australia Exhibit/Poster Hall B0220-B0231 Tuesday, May 03, 2016 11:00 AM-12:45 PM Biochemistry/Molecular Biology 343 Retinoids and carotenoids: Visual cycle and macular pigment Moderator: Lu Chen 3617 — B0220 Retinal and RPE/Choroid Uptake of Lutein, Zeaxanthin, and β-Carotene in Mice. Preejith P. Vachali1, B. Li1, A. Gorusupudi1, Z. Shen3, B. M. Besch2, S. Longo3, K. Nelson1, P. S. Bernstein1.1Ophthalmology, University of Utah, Salt Lake City, UT; 2School of Medicine, University of Utah, Salt Lake City, UT; 3University of Utah, Salt Lake City, UT 3618 — B0221 In vivo Mechanisms of mesoZeaxanthin Production. Paul S. Bernstein, R. Shyam, A. Gorusupudi, B. Li, P. P. Vachali, K. Nelson. Department of Ophthalmology, Univ of Utah/Moran Eye Center, Salt Lake City, UT 3619 — B0222 Macular pigment spatial profile classification: are our eyes deceiving us? Byki Huntjens, I. Ctori. Optometry and Visual Science, City University London, London, United Kingdom 3620 — B0223 Do ethnic variations in foveal morphology explain variations in macular pigment spatial density distribution? Irene Ctori, B. Huntjens. Optometry and Visual Science, City University London, London, United Kingdom 3621 — B0224 RPE-specific knock-out of Retinol Dehydrogenase 10 altered retinoid profile. Younghwa Shin1, G. P. Moiseyev1, K. M. Farjo1, Y. Takahashi2, J. Ma1. 1Physiology, University of Oklahoma HSC, Oklahoma City, OK; 2 Endocrinology, University of Oklahoma HSC, Oklahoma City, OK 3622 — B0225 Role of CD36 in Carotenoid Transport in the Vertebrate Eye. Rajalekshmy Shyam, P. P. Vachali, A. Gorusupudi, P. S. Bernstein. Ophthalmology, University of Utah, Salt Lake City, UT 3623 — B0226 Sodium 4-Phenylbutyrate Improves Cone Survival and Function in a Mouse Model for Leber Congenital Amaurosis. Songhua Li1, M. Samardzija2, Z. Yang1, C. Grimm2, M. Jin1. 1Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA; 2 Department of Ophthalmology, University of Zurich, Zurich, Swaziland 3624 — B0227 Crystal Structure of the Human Lutein-Binding Protein (StARD3) Binding Domain with Phase Extension to 1.74 Å Resolution. Binxing Li1, M. P. Horvath2, E. W. George2, Q. Tran2, S. Shihab1, T. Mattinson1, P. S. Bernstein1. 1Department of Ophthalmology, Univ of UT Sch Med/Moran Eye Ctr, Salt Lake City, UT; 2 Department of Biology, University of Utah, Salt Lake City, UT 3625 — B0228 Heterologous Expression of Functional PDE6 Requires Cooperative Action of AIPL1 and the Inhibitory Pγ-subunit. Kota Gopalakrishna, K. Boyd, N. Artemyev. Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 3626 — B0229 Acyl-CoA synthetase and N-terminal regions of fatty acid transport protein 4 (FATP4) are important for interacting with and inhibiting RPE65 isomerase of the visual cycle. Minghao Jin, J. F. Green, S. Adtani, S. Li. Department of Ophthalmology, LSU School of Medicine, New Orleans, LA 3627 — B0230 The Photosensitivity of Rhodopsin and the Spectral Reflectivity of the Mouse Fundus Measured in Vivo with Scanning Laser Ophthalmoscopy. Pengfei Zhang1, M. Goswami1, R. J. Zawadzki1, 2, E. N. Pugh1. 1Cell Biology and Human Anatomy, University of California, Davis, Davis, CA; 2Ophthalmology & Vision Science, UC Davis, Sacramento, CA 3628 — B0231 Interrelationships between Macular, Skin, and Serum Carotenoids. Christopher D. Conrady, J. E. Bell, B. M. Besch, A. Gorusupudi, W. Gellermann, K. Farnsworth, P. S. Bernstein. Ophthalmology, University of Utah Moran Eye Center, Salt Lake City, UT *CR Exhibit/Poster Hall B0301-B0330 Tuesday, May 03, 2016 11:00 AM-12:45 PM Retinal Cell Biology 344 Angiogenesis: Molecular and Cellular Effectors I Moderator: Baerbel Rohrer 3629 — B0301 Retinal HIF-1α and VEGF levels differ between C57BL/6N and C57BL/6J mice with hyperoxia induced lung injury. Michelle Lajko1, H. J. Cardona2, J. M. Taylor2, K. N. Farrow2, A. A. Fawzi1. 1Dept of Ophthalmology, Feinberg School of Medicin at Northwestern University, Chicago, IL; 2Dept of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, IL 3630 — B0302 Nuclear receptor RORa regulates retinal inflammation and neovascularization in retinopathy through SOCS3. Chi-Hsiu Liu1, Y. Sun1, J. SanGiovanni2, L. Evans1, K. Tian1, A. Stahl3, T. Kamenecka4, L. Solt4, J. Chen1. 1Department of Ophthalmology, Boston Children’s Hospital, Boston, MA; 2National Institutes of Health, Bethesda, MD; 3University of Freiburg, Freiburg, Germany; 4the Scripps Research Institute, Jupiter, FL The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 248 Tuesday – Posters – 3631 – 3649 3631 — B0303 Comparative Systems Pharmacology of HIF Stabilization in the Prevention of Retinopathy of Prematurity. George Hoppe1, S. Yoon1, B. Gopalan2, R. Brown1, K. Case1, A. Vasanji3, E. R. Chan4, J. E. Sears1, 5. 1 Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 2Yorg Corp, Plano, TX; 3ImageIQ Inc, Cleveland, OH; 4Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH; 5Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH 3632 — B0304 A study of ocular blood flow in oxygen-induced ischemic retinopathy model rats using Laser Speckle Flowgraphy-Micro. Tadashi Matsumoto1, Y. Saito2, T. Itokawa1, T. shiba1, H. Takahashi2, Y. Hori1. 1Toho University Omori Medical Center, Ota-ku, Japan; 2School of Medicine Showa University, Tokyo, Japan 3633 — B0305 Following an oxygen-induced retinopathy Wnt/β-catenin signaling in microvascular endothelial and Müller cells is essential for vascular repair. Andreas Ohlmann, B. B. Mueller, D. Woehl, E. R. Tamm. Dept. of Anatomy, University of Regensburg, Regensburg, Germany 3635 — B0307 The Role of Hyperoxia-Induced Vaso-obliteration of Cerebral Blood Vessels and Glycolysis in the Development of ROP and PVL. Lingkun Kong1, H. leeming1, C. Patel2, K. B. Ghaghada2, K. W. Wright3. 1Ophthalmology, Baylor College of Medicine, Houston, TX; 2The Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, TX; 3Ophthalmology, Keck School of Medicine, Los Angeles, CA 3636 — B0308 Non-vascular alterations and functional impairment persist after Anti-VEGF therapy in Oxygen Induced Retinopathy (OIR) mouse model. Magali E. Ridano1, V. E. Lorenc1, 2, P. Subirada1, M. Paz1, D. O. Croci Russo3, J. D. Luna Pinto4, G. A. Rabinovich3, M. C. Sanchez1. 1 Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Córdoba, CICIBI-CONICET, Córdoba capital, Argentina; 2 Department of Ophthalmology, The Johns Hopkins School of Medicine, Baltimore, MD; 3Faculty of Medicine, University of Buenos Aires, IByMECONICET, Capital Federal, Argentina; 4Private Eye Center Romagosa, VER Foundation, Córdoba capital, Argentina 3638 — B0310 Inhibition of Uncoupling Protein 2 Promotes Postnatal Growth and Physiologic Retinal Vascular Development in a Rat Model of Oxygen Induced Retinopathy. Xiaokun Han1, 2, A. J. Liu1, E. Kunz1, C. A. Bretz1, M. Hartnett1, H. Wang1. 1Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT; 2Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China 3639 — B0311 Ferrochelatase is required for retinal neovascularization. Halesha D. Basavarajappa1, 2, L. C. Shaw1, S. L. Calzi1, K. Sishtla1, M. B. Grant1, T. W. Corson1, 2. 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN; 2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN *CR 3640 — B0312 Dysregulated autophagy contributes to pathological angiogenesis in a mice model of retinal angiomatous proliferation. Heckel E, Pundir S, Patel G, Kim JS, Lacombe MJ, Saba N, Fredrick T, Sun Y, Smith LEH, Joyal JS. Emilie Heckel1, S. Pundir1, G. Patel1, J. Kim Suang1, L. Marie Josee1, N. Saba2, T. Fredrick2, L. E. Smith2, J. Joyal1. 1Pharmacology, CHU SainteJustine, Montreal, QC, Canada; 2Childrens.Harvard, Boston, MA 3641 — B0313 Erythropoietin receptor signaling contributes to the development of pathologic retinal angiogenesis. Colin A. Bretz1, H. Wang1, S. Becker1, V. Divoky2, M. Hartnett1. 1 Ophthalmology, John A Moran Eye Center, Salt Lake City, UT; 2Biology, Palacky University, Olomouc, Czech Republic 3642 — B0314 Neovascular changes and angiogenic factor production during combined intrauterine growth restriction and oxygeninduced retinopathy. Silke Becker1, H. Wang1, B. Yu3, R. H. Lane2, M. Hartnett1. 1John A. Moran Eye Center, University of Utah, Salt Lake City, UT; 2 Children’s Hospital of Wisconsin, Wilwaukee, WI; 3 Department of Neonatology, University of Utah, Salt Lake City, UT 3643 — B0315 Myeloid cell ER-stress contributes to pathological retinal neovascularisation in ischemic retinopathy. Gaëlle Mawambo1, A. Dejda2, K. Miloudi3, P. Sapieha1, 2. 1Biochemistry, University of Montreal, Montreal, QC, Canada; 2Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, Montreal, QC, Canada; 3Neurology and Neurosurgery, McGill University, Montreal, QC, Canada 3644 — B0316 Receptor-independent activation of Wnt Signaling protects retinal vasculature and visual function in a mouse model of familial exudative vitreoretinopathy. Zhongxiao Wang, C. Liu, Y. Sun, Y. Gong, J. D. Akula, J. Chen, T. Favazza, N. Saba, T. Fredrick, P. Morss. Ophthalmolopgy, Boston Children’s Hospital, Boston, MA 3645 — B0317 PEDF Expression Regulates Retinal Endothelial Cell Proangiogenic Properties through Modulation of Extracellular Matrix and Cell Junctional Proteins. Nader Sheibani2, 1, S. Park2, J. Falero-Perez2, C. M. Sorenson3, 1. 1McPherson Eye Research Institute, Univ of Wisconsin-Madison, Madison, WI; 2 Ophthalmology, University of Wisconsin-Madison, Madison, WI; 3Pediatrics, University of WisconsinMadison, Madison, WI 3646 — B0318 Thrombospodin-1 Inhibition of Neovascularization in the Retina and Jaw as a Contributing Factor in BisphosphonateRelated Osteonecrosis of the Jaw (BRONJ). Bennett McAllister1, T. Harris1, J. Borke2, S. Kang2, S. Nakasato2, J. Elo2, S. Fulzele3, C. Guerra2. 1 College of Optometry, Western University of Health Sciences, Pomona, CA; 2College of Dental Medicine, Western University of Health Sciences, Pomona, CA; 3Medical College of Georgia, Augusta University, Augusta, GA 3647 — B0319 Old player, new game: supplementing, rather than inhibiting, CCL2 may more effectively limit retinal neovascularization. Salome Murinello1, P. D. Westenskow1, 2, E. Aguilar1, A. Schrick3, M. Friedlander1. 1Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA; 2The Lowy Medical Research Institute, La Jolla, CA; 3Point Loma Nazarene University, San Diego, CA 3648 — B0320 Role of gremlin, an agonist of vascular endothelial growth factor receptor 2, in retinal angiogenesis. Sang Jin Kim1, 2, J. YUN2, J. Kim2. 1Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of); 2Samsung Biomedical Research Institute, Seoul, Korea (the Republic of) 3649 — B0321 Intravitreal injection of PBS reduces retinal neovascularization in the mouse oxygen-induced retinopathy model. Maria Vähätupa1, 2, H. Uusitalo-Järvinen1, 3, T. Järvinen4, 3, H. M. Uusitalo1, 3, G. Kalesnykas2, 1. 1Department of Ophthalmology, University of Tampere, Tampere, Finland; 2Experimentica Ltd., Kuopio, Finland; 3 Tampere University Hospital, Tampere, Finland; 4 Department of Anatomy, University of Tampere, Tampere, Finland *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 249 Tuesday Posters 11:00 am – 12:45 pm 3634 — B0306 Sirt3-deficient retina revascularizes faster by shifting cellular metabolism towards glycolysis in a mouse model of proliferative retinopathy. Sheetal Pundir1, 2, E. Heckel3, 2, J. Kim Suang1, 2, G. Patel3, 2, L. Marie Josee2, D. Toledano2, J. Joyal1, 2. 1Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada; 2Research, CHU-St. Justine Hospital, Montreal, QC, Canada; 3Pharmacology, University of Montreal, Montreal, QC, Canada 3637 — B0309 Endomucin inhibits VEGFinduced endothelial cell migration, growth, and morphogenesis by suppressing VEGFR2 signaling. Patricia A. D’Amore, C. Park-Windhol, Y. Ng, J. Yang, V. Primo, M. Saint-Geniez. Ophthalmology, Schepens Eye Res Inst, MEEI, Boston, MA *CR 3650 – 3666 – Tuesday – Posters 3650 — B0322 Role of the BMP9/Alk1 signaling pathway for the prevention of pathological neovascularization. Bruno Larrivee1, 2, K. Ntumba2. 1Ophthalmology, Université de Montréal, Montreal, QC, Canada;2Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada 3651 — B0323 Sustained Intravitreal Drug Delivery with Injectable Polymer-Nanoparticle Hydrogels. Mark W. Tibbitt1, E. A. Appel2, A. Jayagopal3, R. Langer1. 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA; 2 Department of Materials Science & Engineering, Stanford University, Stanford, CA; 3Pharma Research and Early Development, Ophthalmology Discovery and Biomarkers, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland *CR Tuesday Posters 11:00 am – 12:45 pm 3652 — B0324 Bone marrow derived CX3CR1+ progenitors facilitate vascular repair in a murine model of ischemic retinopathy. Edith Aguilar, S. Sakimoto, S. Murinello, P. D. Westenskow, Y. Usui, F. Bucher, M. Kitano, D. Feitelberg, M. Friedlander. Cell Biology, Scripps Research Institute, Del Mar, CA 3653 — B0325 Regulation of oxidative stress and inflammation by Nrf2 improves revascularization in oxygen-induced retinopathy. Yanhong Wei1, J. gong1, R. K. Thimmulappa2, S. Biswal2, E. J. Duh1.1Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD; 2 Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 3654 — B0326 Effects of human endothelial colony forming cells on oxygen induced retinopathy in various immune competent celldepleted mice. Susumu Sakimoto1, E. Aguilar1, V. Marchetti2, S. Murinello1, Y. Usui1, F. Bucher1, D. Feitelberg1, J. K. Trombley1, P. D. Westenskow1, M. Friedlander1. 1Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA; 2Stemcell Technologies, Vancouver, BC, Canada *CR 3655 — B0327 Preventing pathological angiogenesis in the retina using a microRNA that regulates endothelial cell survival. Daniel Feitelberg1, F. Bucher1, P. D. Westenskow1, E. Aguilar1, Y. Usui1, S. Murinello1, C. M. Wittgrove1, P. Keshavarzian2, S. Weis2, D. Cheresh2, M. Friedlander1. 1Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA; 2Department of Pathology and Moores Cancer Center, University of Calfornia, San Diego, La Jolla, CA 3656 — B0328 The role of DNA repair in the choice between sprouting or proliferating angiogenesis in the context of proliferative retinopathies. Matina Economopoulou1, M. Troulinaki2, R. Garcia-Martin2, L. E. Pillunat1, A. Nussenzweig3, T. Chavakis2. 1Ophthalmology, University clinic, TU Dresden, Dresden, Germany; 2 IKL, University Clinic, TU Dresden, Dresden, Germany; 3NCI, NIH, Bethesda, MD 3657 — B0329 Disruption of astrocytic gap junctions promotes revascularization and diminishes abnormal vessel growth in oxygeninduced retinopathy. Nefeli Slavi1, J. Ackert1, H. Wulff2, M. Srinivas1.1Biological and Vision Sciences, SUNY College of Optometry, New York, NY; 2Pharmacology, University of California, Davis, California, CA 3658 — B0330 Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis. Margaret Dellett, E. Brown, J. Guduric-Fuchs, R. Medina, D. A. Simpson. Centre for Experimental Medicine, Queen’s University Belfast, Belfast, United Kingdom Exhibit/Poster Hall C0133-C0161 Tuesday, May 03, 2016 11:00 AM-12:45 PM Anatomy and Pathology/Oncology 345 What is New in Retinoblastoma? Moderators: Matthew W. Wilson and Timothy W. Corson 3659 — C0133 Decreasing cell survival in Retinoblastoma through PDGFR- β blockade. Zachary Goldsmith1, V. M. Morales1, 3, M. McEwen1, W. Coppess1, A. Irvine1, R. C. Brennan1, 2, M. W. Wilson1, 4.1Ophthalmology, University of Tennessee Health Science Center, Memphis, TN; 2Oncology, St. Jude Children’s Research Hospital, Memphis, TN; 3Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN; 4Surgery, St. Jude Children’s Research Hospital, Memphis, TN 3660 — C0134 Determining the Role of Adhesion G-Protein Coupled Receptors in Retinoblastoma. Jonathan Guihurt Santiago, R. Herrera Camacho, J. Flores Otero. Anatomy and Neurobiology, UPR-RCM Institute of Neurobiology, San Juan, PR 3662 — C0136 Hypoxia and Notch inhibition both enhance sensitivity of Retinoblastoma cells to Melphalan. Laura Asnaghi, Q. Yang, A. Tripathy, A. Hanaford, H. Kaur, C. Eberhart. Johns Hopkins University, Baltimore, MD 3663 — C0137 Gene Expression Profiles of Retinoblastoma Cells with Different Proliferation Patterns: Focusing on Genes Regarding Cell-to-Cell and Cell-to-Matrix Adhesion. Do Yeh Yoon2, 1, D. Jo2, 3, J. Kim2, 4, Y. Yu2, 1, J. Kim2, 3. 1Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea (the Republic of); 2Fight against AngiogenesisRelated Blindness (FARB) Laboratory, Clinical Research Institute, Seoul, Korea (the Republic of); 3 Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea (the Republic of); 4 Tumor Microenvironment Research Center, Global Core Research Center, Seoul National University, Seoul, Korea (the Republic of) 3664 — C0138 Expression of Stem Cell Markers: ABCG2, MCM2 and C-kit in Retinoblastoma. Bhavna Chawla1, A. Gadkar1, S. Mohanty2, M. Sharma2. 1Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 2Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India 3665 — C0139 Looking for the best retinoblastoma mouse model using in vivo spectral domain optical coherence imaging. Stephanie Lemaitre1, 3, F. Poyer1, N. Cassoux2, 3, F. Doz5, L. Desjardins2, P. Freneaux4, C. Thomas1. 1 CMIB : Chemistry, Modelling and Imaging for Biology, Institut Curie, ORSAY, France; 2 Ophtalmology oncology, Institut Curie, Paris, France; 3Université Paris Descartes, PARIS, France; 4Biopathology, Institut Curie, Paris, France; 5 Pediatric Oncology, Institut Curie, Paris, France 3666 — C0140 Preclinical Acute Safety Study of Combined Intravitreal Carboplatin, Etoposide Phosphate, and Topotecan for Retinoblastoma with Vitreous Seeding. Stephen J. Smith1, H. E. Grossniklaus2, A. Smith4, V. Elner1, J. Harbour3, B. Smith5, B. G. Mohney6. 1Ophthalmology, University of Michigan, Ann Arbor, MI; 2Ophthalmology, Emory University, Atlanta, GA; 3Ophthalmology, UNiversity of Miami, Bascom Palmer Eye Institute, Miami, FL; 4SUNY Brockport, Rochester, NY; 5 Hematology/Oncology, University of Rochester, Rochester, NY; 6Ophthalmology, Mayo Clinic, Rochester, MN 3661 — C0135 Growth hormone-releasing hormone (GHRH) antagonist induces apoptosis in retinoblastoma. WAI KIT CHU1, F. Li1, K. Law1, S. CHAN2, H. Cheung4, A. Schally3, C. C. Pang1. 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 3Endocrine, Polypeptide and Cancer Institute, University of Miami, Miami, FL; 4Department of Biomedical Engineering, University of Miami, Miami, FL The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 250 Tuesday – Posters – 3667 – 3687 3667 — C0141 A novel rabbit model of intraarterial chemotherapy / ophthalmic artery chemosurgery. Anthony B. Daniels8, 9, M. T. Froehler2, J. M. Pierce1, A. Nunnally4, T. M. Bridges5, D. L. Friedman6, 9, A. Richmond7, 3. 1 Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Nashville, TN; 2Cerebrovascular Program, Vanderbilt University Medical Center, Nashville, TN; 3Cancer Biology, Vanderbilt University, Nashville, TN;4Surgical Research, Vanderbilt University Medical Center, Nashville, TN; 5Pharmacology, Vanderbilt University, Nashville, TN; 6Pediatrics, Vanderbilt University Medical Center, Nashville, TN; 7Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN; 8Ophthalmology and Visual Sciences, Cancer Biology, and Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN; 9Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 3668 — C0142 Rabbit model of ocular photodynamic therapy using an indirect ophthalmoscope delivery system. Jonathan W. Kim1, 2, P. Chevez-Barrios3. 1Children’s Hospital Los Angeles, Los Angeles, CA;2Ophthalmology, USC Eye Institute, Los Angeles, CA; 3Pathology, Methodist Hospital, Houston, TX 3670 — C0144 The Value of “en toto” globe submission in the assessment of high risk retinoblastoma cases and subsequent plan for treatment. Hani ALBalawi1, H. Al-Khatan2, A. Maktabi3. 1University Of Tabuk, Tabuk, Saudi Arabia; 2King Saud University, Riyadh, Saudi Arabia; 3King Khaled Eye specialist Hospital, Riyadh, Saudi Arabia 3671 — C0145 Increased Frequency of Positive Family History of Retinoblastoma in Recently Encountered Cases. Rafaela Faraj, Z. M. Correa, J. J. Augsburger. Ophthalmology, University of Cincinnati, Cincinnati, OH 3672 — C0146 The clinical presentation of retinoblastoma patients with mosaics. Shahar Frenkel, J. Pe’er. Ophthalmology, HadassahHebrew Univ Med Ctr, Jerusalem, Israel 3673 — C0147 Fluorescein Angiography Findings in Diffuse Retinoblastoma: Two Case Reports With Clinicopathologic Correlation. Maria Paula Fernandez1, S. N. Al-Holou3, O. G. Fischer1, A. M. Berrocal2, S. R. Dubovy1. 1Ocular Pathology Laboratory, bascom Palmer Eye Institute, Miami, FL; 2Bascom Palmer Eye Institute, Mimai, FL; 3Henry Ford Hospital, Detroit, MI 3676 — C0150 An International Survey of Classification and Treatment Choices for Group D Retinoblastoma Eyes. Christina Scelfo1, J. H. Francis1, T. L. Jenkins2, B. P. Marr1, D. H. Abramson1. 1Memorial Sloan Kettering Cancer Center, New York, NY; 2WillsEye Hospital, Philadelphia, PA 3677 — C0151 Visual outcomes of macular retinoblastoma tumors treated with systemic chemotherapy and repetitive laser ablation. Julia Sein, G. Lueder. Ophthalmology, Washington University in St. Louis, St Louis, MO 3678 — C0152 Anterior chamber seeding in retinoblastoma: is it an indication for adjuvant chemotherapy. A long term follow up study. Vikas Khetan, S. Krishnakumar, S. Kummamuri, A. Ramesh. Ophthalmology, Sankara Nethralaya, Chennai, India 3679 — C0153 Brachytherapy with Ru106 plaques as a primary treatment for retinoblastoma in Israel. Jacob Pe’er, S. Frenkel. Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 3680 — C0154 Retinal reattachment and ERG recovery after ophthalmic artery chemosurgery for advanced retinoblastoma in eyes with minimal baseline retinal function. Aliaa H. Abdelhakim1, J. H. Francis1, 2, P. Gobin1, 3, B. P. Marr1, 2, D. H. Abramson1, 2, S. E. Brodie1, 4. 1 Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY; 2Ophthalmology, Weill Cornell Medical College, New York, NY; 3 Interventional Neuroradiology, Weill Cornell Medical College, New York, NY; 4Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 3681 — C0155 Dynamics of New Tumor Development during and after Chemotherapy against Retinoblastoma: Groundwork for Novel Translational Approaches. Dong Hyun Jo2, 1, J. Kim2, 3, Y. Yu2, 4, J. Kim2, 1. 1Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea (the Republic of); 2Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea (the Republic of); 3Tumor Microenvironment Research Center, Global Core Research Center, Seoul National University, Seoul, Korea (the Republic of); 4Department of Ophthalmology, College of Medicine, Seoul National University Hospital, Seoul, Korea (the Republic of) 3682 — C0156 Concomitant first line intra-arterial (IAC) and intra-vitreal (IVC) chemotherapy with melphalan for unilateral group D retinoblastoma (Rb) with diffuse vitreous seeding at presentation.Francis L. Munier1, M. Gaillard1, C. Stathopoulos1, M. Beck-Popovic2, F. Puccinelli3, S. L. Houghton1. 1 Ophthalmology, Jules-Gonin Eye Hospital, Lausanne, Switzerland; 2Pediatric HematologyOncology Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 3Neuroradiology Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland 3683 — C0157 Multimodal analysis of macular toxicity following intra-arterial (IAC) and/or intravitreal (IVC) melphalan in retinoblastoma (Rb): evidence for infra-clinical changes by optic coherence tomography (OCT) and adaptive optics (AO). yousra Falfoul1, A. Dirani1, M. Gaillard1, F. Puccinelli2, M. Beck-Popovic2, F. L. Munier1. 1Hopital Ophtalmique, Jules Gonin, Lausanne, Switzerland; 2centre hospitalier universitaire vaudois, Lausanne, Switzerland 3684 — C0158 Combined Melphalan/ Topotecan intra-arterial chemotherapy (MTIAC) for salvage in retinoblastoma relapse following melphalan intra-arterial chemotherapy (M-IAC). Anthony Manassero1, M. Gaillard2, C. stathopoulos2, S. houghton2, F. puccinelli3, M. BeckPopovic3, F. L. Munier2. 1Fondation Rothschild, Paris, France; 2Hopital Ophtalmique Jules Gonin, Lausanne, Switzerland; 3CHUV, Lausanne, Switzerland 3685 — C0159 Ophthalmic artery chemosurgery as a local route for optic nerve delivery of chemotherapy. Paula Schaiquevich1, P. Taich1, F. Requejo2, M. Asprea2, M. Sgroi2, P. Gobin3, D. H. Abramson3, G. Chantada2. 1 CONICET-Hosp de Ped JP Garrahan, Ciudad, Argentina; 2Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina; 3Memorial Sloan Kettering Cancer Center, NYC, NY 3686 — C0160 Acute Vaso-occlusion and Chorioretinal Toxicity following Intravitreal Melphalan Injection. Hassan A. Aziz, J. L. Berry, J. W. Kim. Ophthalmology and Visual Sciences, USC Eye Institute, Miami, FL 3687 — C0161 Intraocular Pressure Changes Following Intravitreal Melphalan and Topotecan for the Treatment of Retinoblastoma with Vitreous Seeding. Matthew Karl, J. Francis, S. Iyer, B. P. Marr, D. H. Abramson. Ophthalmology, Memorial Sloan Kettering Cancer Center, New York, NY *CR 3674 — C0148 Retrograde Differentiation of Retinoblastoma in Infants. Ananth Sastry, H. A. Aziz, J. L. Berry, J. W. Kim. Ophthalmology, USC Eye Institute, Los Angeles, CA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 251 Tuesday Posters 11:00 am – 12:45 pm 3669 — C0143 Analysis of Nucleic Acid content in the Aqueous Humor of Retinoblastoma Eyes. Jesse L. Berry1, 2, J. W. Kim2, 1. 1Ophthalmology, USC Eye Institute, Los Angeles, CA; 2 Ophthalmology, The Vision Center at Children’s Hospital Los Angeles, Los Angeles, CA 3675 — C0149 Clinical Characterization of Vitreous Seeds in Retinoblastoma. Jasmine H. Francis1, 2, B. P. Marr1, 2, D. H. Abramson1, 2. 1 Ophthalmic Oncology, Memorial Sloan Kettering Cancer Center, New York, NY; 2Ophthalmology, Weill Cornell Medical Center, New York, NY *CR 3688 – 3707 – Tuesday – Posters Exhibit/Poster Hall D0099-D0123 Tuesday, May 03, 2016 11:00 AM-12:45 PM Retina 346 AMD Clinical Research 2 Moderators: Pearse A. Keane and Yoko Ozawa Tuesday Posters 11:00 am – 12:45 pm 3688 — D0099 Effects of central macular thickness on visual and anatomical outcomes in age-related macular degeneration patients: comparison between ranibizumab and aflibercept. Shinichi Sakamoto1, H. Takahashi1, 2, Y. Inoue1, 3, Y. Yanagi3, 4, A. Sato1, M. Takezawa1, T. Tanabe2, Y. Fujino2, H. Kawashima1. 1 Ophthalmology, Jichi medical university, Shimotsuke-city, Japan; 2JCHO Tokyo Shinjyuku Medhical Center, Tokyo, Japan; 3Ophthalmology, Tokyo university, Tokyo, Japan; 4Singapore National Eye Centere, Singapore, Singapore *CR 3689 — D0100 Predictive factors for nonresponse to intravitreal aflibercept treatment in neovascular age-related macular degeneration. Norihiro Nagai1, 2, M. Suzuki1, 2, A. Uchida2, T. Kurihara2, M. Kamoshita1, 2, S. Minami2, H. Shinoda2, K. Tsubota2, Y. Ozawa1, 2. 1Laboratory of Retinal Cell Biology, Keio University, School of Medicine, Tokyo, Japan; 2Ophthalmology, Keio University, School of Medicine, Tokyo, Japanf 3690 — D0101 Natural History of RodMediated Dark Adaptation Over 2 Years in Eyes with Intermediate Age-Related Macular Degeneration. Cynthia Owsley1, M. Clark1, G. McGwin2, 1, E. C. Strauss3.1Dept of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL; 2Epidemiology, University of Alabama at Birmingham, Birmingham, AL; 3 Genentech, South San Francisco, CA *CR 3691 — D0102 Face stimulus challenges visual processing in age-related macular degeneration. Pasi Vottonen1, K. Kaarniranta1, 2, A. Pääkkönen3, I. M. Tarkka4. 1Ophthalmology, Kuopio University Hospital, Kuopio, Finland; 2University of Eastern Finland, Kuopio, Finland; 3Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland; 4Health Sciences, University of Jyväskylä, Jyväskylä, Finland 3692 — D0103 Low energy stereotactic radiotherapy in combination with an anti VEGF treat and extend regimen for treatment of neovascular age related macular degeneration: 12 month outcomes. Katja B. Hatz1, 2, F. Zimmermann3, D. Kardamakis4, E. Lazaridis5, C. Tuerksever1, 2, C. Pruente1, 2. 1Vista Klinik, Binningen, Switzerland; 2Dep. of Ophthalmology, Kantonsspital Baselland, Liestal, Switzerland; 3Dep. of Radiooncology, University Hospital Basel, Basel, Switzerland; 4Dep. of Radiooncology, Medical School Patras, Patras, Greece; 5EyeRAD SWISS Medical Center, Basel, Switzerland *CR 3693 — D0104 One-year Outcomes following Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in Japanese Patients: The APOLLO study. Yuji Oshima1, K. Kimoto2, N. Yoshida3, K. Fujisawa4, S. Sonoda5, T. Kubota2, T. Murata3, T. Sakamoto5, K. Sonoda1, T. Ishibashi1. 1 Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; 2 Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan; 3Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan; 4Ophthalmology, Japan Community Health care Organization Kyushu Hospital, Kitakyushu, Japan; 5Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan *CR, f 3694 — D0105 Comparative study of different methods for analyzing correlated continuous data. Bernard Rosner1, G. Ying2, R. Glynn1, M. G. Maguire2. 1Medicine (Biostatistics), Harvard Medical School, Boston, MA; 2Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 3695 — D0106 Systemic confounders for serum patterns of omega-3- and -6-polyunsaturated fatty acids in patients with different retinal pathologies. Anima Buehler1, M. Augustynik1, F. Bucher1, J. Wöhrl2, G. Martin1, G. R. Schlunck1, H. Agostini1, D. Boehringer1, G. Pütz2, A. Stahl1. 1 Eye Center, Albert-Ludwigs-University Freiburg, Freiburg, Germany; 2Department of Clinical Chemistry, University Hospital Freiburg, Freiburg, Germany *CR 3696 — D0107 Rapid evaluation of risk factors linked to age-related macular degeneration (AMD): STARS questionnaire. M Isabel Lopez7, 8, A. Garcia-Layana3, 4, F. Gomez Ulla1, 6, J. RuizMoreno2, 7, M. S. Figueroa5, 6, J. Pastor8, 3. 1Instituto Gomez Ulla, Santiago de Compostela, Spain; 2 Universidad de Castilla la Mancha, Albacete, Spain; 3RETICS OFTARED, Madrid, Spain; 4 Clinica Universitaria de Navarra, Pamplona, Spain; 5Hospital Ramón y Cajal, Madrid, Spain; 6 Fundación Retina Plus +, Santiago de Compostela, Spain; 7Sociedad Española de Retina y Vitreo, Santiago de Compostela, Spain; 8IOBA/HCUV, Valladolid, Spain *CR 3697 — D0108 Detecting Macular Degeneration with Diagnostic Retinoscopy. Clinton N. Sims. Department of Ophthalmology and Visual Sciences, University of Louisville, Ft Myers, FL *CR 3698 — D0109 Expression of VEGF-A, VEGF-C, VEGF-D and soluble receptors in Clinical Age-Related Macular Degeneration. Gianna C. Teague1, J. Ma1, W. Johnson2, M. E. Baldwin3, K. Lashkari1.1Schepens Eye Research Institute, Massachusetts Eye & Ear Infirmary, Boston, MA; 2Department of Physics, Suffolk University, Boston, MA; 3Circadian Technologies Ltd, Opthea Pty Ltd, South Yarra, VIC, Australia *CR 3699 — D0110 Incidence rate of massive submacular hemorrhage and its risk factors in polypoidal choroidal vasculopathy. Joon Hee Cho, N. Ryoo, K. Cho, K. Park, S. Woo, S. Park. Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea (the Republic of) 3700 — D0111 The reliability of rod and cone sensitivity measurements using a novel darkadapted chromatic perimeter. Rose S. Tan1, 2, R. H. Guymer1, 2, E. Caruso1, C. D. Luu1, 2. 1Centre for Eye Research Australia, Melbourne, VIC, Australia; 2 Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, VIC, Australia 3701 — D0112 Practice patterns in agerelated macular degeneration (AMD). Angelica Ly, L. Nivison-Smith, B. Zangerl, M. Kalloniatis. Centre for Eye Health, SOVS, UNSW Australia, Kensington, NSW, Australia 3702 — D0113 Perception of Haidinger’s Brushes in Macular Disease Depends on Macular Pigment Optical Density and Visual Acuity. Philipp L. Mueller, S. Müller, M. Gliem, K. Küpper, F. G. Holz, W. M. Harmening, P. Charbel Issa. Department of Ophthalmology, University of Bonn, Bonn, Germany *CR 3703 — D0114 One year results of intravitreal aflibercept injection in the treatment of wet age related macular degeneration. Awatif O. Barakat, C. Ton Van, J. Hung, S. Bouakaz, T. Tran. Ophthalmology, Lille Catholic Hospitals, Lille, France 3704 — D0115 Intravitreal Autologous Bone Marrow Derived Stem Cells in Dry Age-related Macular Degeneration. Rubens C. Siqueira, C. Costa Cotrim, A. Messias, M. V. Sousa, L. Toscano, R. Jorge. Ophthalmology, Sao Paulo University, Sao Jose do Rio Preto, Brazil f 3705 — D0116 New rapid digital dark adaptometer that shows high sensitivity and specificity for early AMD. Ian Murray, D. Carden, J. M. Kelly. Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom *CR 3706 — D0117 Dark adaptation impairment in patients with drusen. Miriam Garcia Planas1, 2, M. Biarnes1, 2, J. Mones1, 2. 1Institut de la Macula, Barcelona, Spain; 2Barcelona Macula Foundation, Barcelona, Spain 3707 — D0118 Impact of optical coherence tomography (OCT) on decision to continue treatment for neovascuar age-related macular degeneration. Cornelia Volz1, F. Grassmann2, R. Greslechner1, D. A. Maerker1, P. Peters1, H. Helbig1, M. Gamulescu1. 1University Eye Clinic, University of Regensburg, Parsberg, Germany; 2 Institute of Human Genetics, University of Regensburg, Regensburg, Germany The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 252 Tuesday – Posters – 3708 – 3723 3708 — D0119 Recurrence of neovascular (wet) age-related macular degeneration (AMD) in patients discharged from care in a real-world clinical practice in the UK. fadi alfaqawi, S. Elsherbiny, B. Mushtaq. Birmingham and Midland Eye Centre, Birmingham, United Kingdom 3709 — D0120 Threshold versus Area Assessment to Determine Aspects of Rod Photoreceptor Loss in Subjects with AgeRelated Macular Degeneration (AMD). Tad Daniels1, J. Felius1, 2, D. G. Birch1, 2, K. G. Csaky1, 2. 1 Retina Foundation of the Southwest, Dallas, TX; 2 Opthalmology, University of Texas Southwestern Medical Center, Dallas, TX 3710 — D0121 Biofluids NMR metabolomics in Age-related macular degeneration. Deeba Husain1, I. Laines1, A. S. Martins2, D. Duarte2, A. Barros2, R. M. Silva3, 4, A. Gil2, J. W. Miller1. 1 Ophthalmology, Mass eye and ear, Harvard Medical School, Boston, MA; 2University of Aveiro, CICECO - Aveiro Institute of Materials, Aveiro, Portugal; 3Faculdadw de Medicina, Universidade de Coimbra, Coimbra, Portugal; 4Association for Innovation and Biomedical Research on Light, Coimbra, Portugal *CR 3712 — D0123 Decreased Plasma Levels of Dickkopf-1 in Patients with Exudative Agerelated Macular Degeneration. Zhen Liu1, F. Qiu1, Y. Zhou1, J. He1, J. Ma2, Z. Liu1. 1medical college of xiamen university, Eye Institute of Xiamen University, Xiamen, China; 2Physiology, The University of Oklahoma Health Sciences Center, Oklahoma, OK Exhibit/Poster Hall D0174-D0203 Tuesday, May 03, 2016 11:00 AM-12:45 PM Retina 347 Retinal Prosthesis and Stem Cells 3715 — D0176 Effect of stimulus pulse on evoked potential amplitude in the superior colliculus of rats by electrical stimulation with Suprachoroidal-Transretinal Stimulation (STS) retinal prosthesis. Yukari Nakano1, Y. Terasawa1, 2, H. Kanda3, K. Osawa1, M. Ozawa4, T. Miyoshi5, H. Sawai6. 1Research and Development Division, Nidek Co., Ltd., Gamagori, Japan; 2Graduate School of Materials Science, Nara Institute of Science & Technology, Ikoma, Japan; 3Department of Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan; 4Nidek Co., Ltd., Gamagori, Japan; 5Department of Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan; 6Department of Health Sciences, School of Nursing, Osaka Prefecture University, Habikino, Japan *CR 3716 — D0177 Development of an alpha retinal ganglion cell model for epiretinal electrode stimulation. Ethan D. Cohen1, E. Neufeld2, H. Montanaro2, M. I. Iacono1, L. M. Angelone1, W. Kainz1. 1Div. Biomedical Physics, Office of Sci. and Eng. Labs, Ctr. for Dev. & Rad. Health, FDA, Silver Spring, MD; 2Computational Life Sciences, IT’IS Research Foundation, Zurich, Switzerland 3717 — D0178 Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type. Maesoon Im1, 2, S. I. Fried2, 3. 1Ophthalmology, Henry Ford Hospital, Northville, MI;2Boston VA Healthcare System, Boston, MA; 3Neurosurgery, Massachusetts General Hospital/HMS, Boston, MA 3718 — D0179 Relative power consumption at the electrode-retina interface during retinal stimulation with voltage versus current controlled stimulus pulses. Kiran Nimmagadda2, 3, N. Davuluri4, J. D. Weiland1, 4. 1Ophthalmology, USC, Los Angeles, CA; 2Neuroscience Graduate Program, University of Southern California, Los Angeles, CA; 3USC - Caltech MD/PhD Program, Los Angeles, CA; 4Biomedical Engineering, University of Southern California, Los Angeles, CA 3719 — D0180 Surgical feasibility of widefield dual-array suprachoroidal-transretinal stimulation (STS) prosthesis in middle-sized animals. Takeshi Morimoto2, H. Kanda2, T. Miyoshi3, T. Endo1, T. K. Lohmann4, 2, K. Nishida1, T. Fujikado2. 1Ophthalmology, Osaka Univ Graduate Sch of Med, Suita, Japan; 2Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan; 3Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan; 4Ophthatmology, Aachen RWTH Aachen University, Aachen, Germany 3720 — D0181 Evaluation of the spatial resolution of electrode arrays for suprachoroidal retinal prosthesis by recording single-unit activities in the lateral geniculate nucleus. Hiroyuki Kanda1, T. Miyoshi2, T. Morimoto1, T. Fujikado1. 1Applied Visual Science, Osaka University Graduate School of Medicine, Suita, Japan; 2Integrative Physiology, Osaka University Graduate School of Medicine, Suita, Japan *CR 3721 — D0182 Spatio-temporal characteristics of retinal responses to subretinal photovoltaic stimulation. Richard Smith1, E. Ho2, G. A. Goetz2, 3, X. Lei3, T. Kamins3, J. Harris3, K. Mathieson4, D. V. Palanker2, 5, A. Sher1. 1Santa Cruz Institute for Particle Physics, UC Santa Cruz, Santa Cruz, CA; 2Hansen Experimental Physics Lab, Stanford, Palo Alto, CA; 3Electrical Engineering, Stanford, Palo Alto, CA; 4Institute of Photonics, University of Strathclyde, Glasgow, United Kingdom; 5 Ophthalmology, Stanford, Palo Alto, CA *CR 3722 — D0183 Spatial aspects of electrical desensitization in mouse retina. Archana Jalligampala1, 2, E. Zrenner1, D. L. Rathbun1. 1 Institute for Ophthalmic Research & Center for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany; 2Graduate Training Center of Neuroscience, University of Tuebingen, Tuebingen, Germany *CR 3723 — D0184 Implications of low prosthetic contrast sensitivity for delivery of visual information. Georges A. Goetz1, 2, R. Smith3, X. Lei4, L. Galambos4, T. Kamins4, K. Mathieson5, A. Sher3, D. V. Palanker2, 6. 1Neurosurgery, Stanford University, Stanford, CA; 2Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA; 3Santa Cruz Institute for Particle Physics, University of California Santa Cruz, Santa Cruz, CA; 4Electrical Engineering, Stanford University, Stanford, CA; 5Institute of Photonics, University of Strathclyde, Glasgow, United Kingdom; 6 Ophthalmology, Stanford University, Stanford, CA *CR Moderators: Eyal Banin and Jose Sahel 3713 — D0174 Evaluation of electrical stimulation of the retina with optical coherence tomography. Alejandra Gonzalez Calle, J. D. Weiland. Biomedical Engineering, University of Southern California, Los Angeles, CA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 253 Tuesday Posters 11:00 am – 12:45 pm 3711 — D0122 Spectral Domain Optical Coherence Tomography 2-Year Localized Precursors to New Onset Geographic Atrophy in Age-Related Macular Degeneration. Malini Veerappan1, V. Tai1, S. Chiu1, K. Winter1, A. El-Hage-Sleiman1, E. Lad1, C. Harrington1, R. Gunther1, W. T. Wong3, E. Y. Chew3, C. A. Toth1, 2. 1 Duke Eye Center, Duke University Medical Center, Durham, NC; 2Department of Biomedical Engineering, Duke University, Durham, NC; 3 National Eye Institute, National Institutes of Health, Bethesda, MD *CR, f 3714 — D0175 Focal electrical stimulation of the retina. Andrew C. Weitz1, 2, D. Nanduri2, R. J. Greenberg3, M. S. Humayun1, 2, R. H. Chow4, 2, J. D. Weiland1, 2. 1Ophthalmology, University of Southern California, Los Angeles, CA; 2Biomedical Engineering, University of Southern California, Los Angeles, CA; 3Second Sight Medical Products, Inc., Sylmar, CA; 4Physiology & Biophysics, University of Southern California, Los Angeles, CA *CR, f 3725 – 3742 – Tuesday – Posters 3725 — D0186 Apoptosis reduction by a photoelectric dye used for Okayama Universitytype retinal prosthesis (OURePTM). Shihui Liu1, T. Matsuo1, O. Hosoya2, T. Uchida3. 1Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; 2Neurogenomics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan;3Polymer Materials Science, Okayama University Graduate School of Natural Science and Technology, Okayama, Japan Tuesday Posters 11:00 am – 12:45 pm 3726 — D0187 Retinal safety of near infrared radiation in photovoltaic restoration of sight. Henri Lorach1, 2, J. Wang1, 2, D. Lee1, 3, R. Dalal1, P. Huie3, D. V. Palanker1, 2. 1Ophthalmology, Stanford University, Stanford, CA; 2HEPL, Stanford University, Stanford, CA; 3Ophthalmology, Gachon University, Incheon, Korea (the Republic of) *CR 3727 — D0188 Fabrication and in-vitro characterization of novel hydrogel-based electrodes for visual prostheses. Yasuo Terasawa1, 3, H. Tashiro2, Y. Nakano1, K. Osawa1, M. Ozawa4, T. Noda3, T. Tokuda3, J. Ohta3, K. Haraguchi5. 1Vision Institute, R&D Div, NIDEK Co Ltd, Gamagori, Japan; 2Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan; 3Materials Science, Nara Institute of Science and Technology, Ikoma, Japan; 4Nidek Co.,Ltd., Gamagori, Japan; 5College of Industrial Technology, Nihon University, Narashino, Japan *CR 3728 — D0189 Focal activation of retinal ganglion cells with epiretinal implants: The AIS as a key component. Paul Werginz1, A. Hadjinicolaou2, 3, S. I. Fried2, 3, F. Rattay1. 1Institute for Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria; 2Vision Research Laboratory, Boston VA Medical Center, Boston, MA; 3Department of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA 3729 — D0190 Extraction of directly-evoked Retinal Ganglion Cell response from stimulus artifact using three artifact subtraction algorithms. Jungryul Ahn1, M. Choi2, D. Park1, K. Koo2, Y. Goo1.1Department of Physiology, School of Medicine, Chungbuk National University, Cheong-ju, Korea (the Republic of); 2Department of Biomedical Engineering, University of Ulsan, Ulsan, Korea (the Republic of) 3730 — D0191 Oscillatory Rhythm in Degenerate Mouse (rd10) Retina Modulates Retinal Ganglion Cell Response to Electrical Stimulus. Dae-jin Park1, J. Ahn1, S. Cha1, Y. Goo1, S. Senok2. 1Department of Physiology, School of Medicine, Chungbuk National University, Cheongju, Korea (the Republic of); 2Neuroscience, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia 3731 — D0192 Towards an improvement of the visual function preservation in RCS rats by transplantation of human stem-cell-derived RPE and photoreceptor precursor cells. Laura Fontrodona1, L. Miquel2, Y. Muñoz2, D. Mora Ramírez1, A. Salas Torras1, B. Ferreira-de-Souza1, M. Riera1, S. Albert2, A. Veiga2, J. Garcia-Arumi1. 1 Ophthalmology, Vall d’Hebron Research Institute (VHIR), Barcelona, Spain; 2Stem Cell Bank, Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain 3732 — D0193 Acute Synaptic and Neuronal Anatomical Changes Following Insertion of Sub-Retinal Electrode Array in an Enucleated Human Eye. Jinghua Chen1, G. DeWalt2, W. Eldred2, M. Gingerich3, D. Shire3, J. F. Rizzo4, H. J. Kaplan1. 1Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY; 2 Department of Biology, Boston University, Boston, MA; 3Bionic Eye Technologies, Inc., Fishkill, NY;4Ophthalmology, Harvard Medical School, Boston, MA *CR 3733 — D0194 ARGUS II® Electronic Epiretinal Prosthesis In Advanced Dry Amd: Safety And Feasibility Study And Preliminary Functional Results. Paulo E. Stanga1, 2, A. Jalil1, E. TSAMIS1, 2, A. Papayannis1, J. D. Dorn3, R. J. Greenberg3, W. Mcguire3. 1Manchester Vision Regeneration (MVR) Lab at Manchester Royal Eye Hospital & NIHR/Wellcome Trust Manchester CRF and Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom; 2Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom; 3Second Sight Medical Products, Inc, Sylmar, CA *CR, f 3734 — D0195 Local and systemic immune responses associated with rejection of iPSderived RPE allografts transplanted into rhesus macaques. Trevor J. McGill1, 2, J. W. Stoddard2, L. M. Renner2, R. Bonnah2, E. Johnson2, I. Messaoudi3, S. T. Bailey1, A. Lauer1, S. Mitalipov3, D. J. Wilson1, M. Neuringer2, 1. 1Ophthalmology, Casey Eye Institute, OHSU, Portland, OR; 2Neuroscience, Oregon National Primate Research Center, Beaverton, OR; 3Oregon National Primate Research Center, Beaverton, OR 3735 — D0196 A New Immunodeficient Dystrophic RCS Rat Model for Transplantation Studies Using Human Derived Cells. Biju Thomas2, C. H. Shih2, D. Zhu1, J. C. Martinez2, D. R. Hinton2, 1, M. S. Humayun2. 1Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA; 2Ophthalmology, University of Southern California Keck School of Medicine, Los Angeles, CA 3736 — D0197 Dissociation protocol and optimal conditions for clinical-grade induced pluripotent stem cell-derived retinal precursor cells. Brittni Scruggs, B. A. Tucker, C. Jiao, J. Riley, E. M. Stone, R. F. Mullins, E. H. Sohn. Wynn Institute for Vision Research, University of Iowa, Iowa City, IA *CR 3737 — D0198 Human retinal progenitor sheet transplants in immunodeficient retinal degenerate (RD) rats. Magdalene J. Seiler1, 2, B. T. McLelland2, A. Mathur2, R. lin2, D. T. Alexander2, P. N. Patel2, B. Cummings1, 2, R. B. Aramant2. 1 Physical Medicine & Rehabilitation, University of California, Irvine, Irvine, CA; 2Sue & Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA *CR 3738 — D0199 Optimizing subretinal injection conditions for retinal gene and stem cell therapy. Elliott H. Sohn, C. Jiao, B. Scruggs, D. Brack, E. M. Stone, R. F. Mullins, B. A. Tucker. University of Iowa Dept of Ophthalmology, Wynn Institute for Vision Research, Iowa City, IA *CR 3739 — D0200 Optimizing a Biodegradable Scaffold for Clinical Applications of iPS Cell Derived RPE Tissue. Vladimir Khristov, N. Hotaling, Y. Li, H. Qian, Q. Wan, R. Sharma, A. Maminishkis, J. Amaral, S. S. Miller, J. Davis, K. Bharti. National Eye Institute, Bethesda, MD 3740 — D0201 Survivability And Surface Coverage Of Human Retinal Pigment Epithelium (Rpe) On Aged Human Bruch’s Membrane (Bm) Can Be Restored Using Patch Grafts Of Young BM. Qun Zeng1, A. Del Priore1, A. Hondur1, L. V. Del Priore2, T. H. Tezel1. 1 Department of Ophthalmology, The Edward Harkness Eye Institute, Columbia University, College of Physicians and Surgeons, New York, NY; 2Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC 3741 — D0202 Intravitreal Autologous Bone Marrow Derived Stem Cells in Ischemic Maculopathy Results after 12 Months Followup. Felipe P. Borges, R. C. Siqueira, M. W. Rodrigues, A. J. Dos Santos, A. Messias, R. Jorge. Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil f 3742 — D0203 Clincal trial: subretinal transplantation of CTS hESC derived RPE in the treatment of wet Age-related Macular Degeneration (wAMD). Zheng Qin Yin1, Y. Liu1, S. Li1, H. Xu1, Y. Wang1, C. Qian2, Q. Zhou3. 1 Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing, China; 2Southwest Hospital,Third Military Medical University, Chongqing, China; 3Institute of zoology,Chinese Acadamy of Sciences, Beijing, China f The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 254 Tuesday – Posters – 3743 – 3758 Exhibit/Poster Hall D0235-D0250 Tuesday, May 03, 2016 11:00 AM-12:45 PM Multidisciplinary Ophthalmic Imaging Group / Anatomy and Pathology/Oncology 348 Functional Imaging Moderators: Xincheng Yao and Ravi S. Jonnal 3743 — D0235 Hyperspectral Measurement of Retinal Oximetry in Diabetes. Joel Kaluzny2, H. Li1, P. L. Nesper2, W. Liu1, H. F. Zhang2, A. Fawzi2. 1Department of Biomedical Engineering, Northwestern University, Evanston, IL; 2 Department of Ophthalmology, Northwestern University, Chicago, IL 3744 — D0236 Hyperspectral snapshot camera for functional imaging of the retina. Jason Dwight1, R. Coffee2, M. E. Pawlowski1, C. Y. Weng2, T. Tkaczyk1. 1Bioengineering, Rice University, Houston, TX;2Ophthalmology, Baylor College of Medicine, Houston, TX 3746 — D0238 Normal limits of retinal oximetry and retinal venous oxygen saturation in atrophic diseases. Olof B. Olafsdottir1, 3, S. H. Hardarson1, 3, E. Vandewalle2, T. Eysteinsson1, 3, M. S. Gottfredsdottir3, K. Van Keer2, L. Abegao Pinto4, I. Stalmans2, E. Stefansson3, 1. 1University of Iceland, Reykjavik, Iceland; 2University Hospitals Leuven, Leuven, Belgium; 3Landspitali University Hospital, Reykjavik, Iceland;4Centro Hospitalar de Lisboa Central, Lisbon, Portugal *CR 3747 — D0239 Comparison of different imaging protocols used in retinal vessel oximetry. Rebekka Heitmar. Optometry & Vision Sciences, Aston University, Birmingham, United Kingdom 3748 — D0240 Automatic quantitative oximetry analysis in smaller retinal microvessels acquired by the retinal function imager, RFI, non-invasively. Sagi -. Reuven1, 2, R. Wilf4, F. -. Rotbart1, J. Wang5, D. DeBuc5, A. Mohan6, A. Grinvald3. 1Optical Imaging Ltd, Rehovot, Israel; 2 IDC Hertzelia, Herzelia, Israel; 3Neurobiology, Weizmann Institute of Science, Rehovot, Israel; 4 Optical Imaging, Rehovot, Israel; 5Bascom Palmer Eye Institute, Miami, FL; 6Narayana Nethralaya, Bangalore, India *CR 3751 — D0243 Impact of oral contranceptive pill (OCP) on vessels functionality. Alessandro Rabiolo, F. Corvi, D. Monteduro, L. Benatti, G. Querques, F. Bandello. Ophthalmology, IRCCS, Vita-Salute San Raffaele University, Milan, Italy *CR 3752 — D0244 Multi-modal optical coherence tomography enables concurrent imaging of retinal neural activity and vascular hemodynamics. Taeyoon Son1, B. Wang1, D. Thapa1, Y. Lu1, D. Cao2, X. Yao1, 2. 1Department of Bioengineering, University of Illinois at Chicago, Chicago, IL; 2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL *CR 3757 — D0249 fMRI Studies: Calpain Inhibitor SNJ-1945 Ameliorates Dysfunction in Injured Rat RGCs. Takayuki Oka1, C. Yabuta1, T. R. Shearer2, M. Azuma1, 2. 1Senju Laboratories of Ocular Sciences, Senju Pharmaceutilal Co Ltd, Kobe, Japan; 2Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR *CR 3758 — D0250 Visualizing retina signal transduction with dual beam electron imaging. Holland Cheng1, L. Xing1, H. Wang1, R. Luo2, J. Shyue2, P. G. FitzGerald1, K. Lam1. 1University of California, Davis, CA;2NanoLab, Milpitas, CA 3753 — D0245 Retinotopic Mapping After Bilateral Implantation Of A Multifocal Diffractive IOL. José F. Costa1, A. C. Rosa1, 2, Â. Miranda3, C. F. Lobo1, 2, F. Silva4, M. CasteloBranco2, 4, J. N. Murta1, 2. 1Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 2Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal; 3ICNAS - Institute for Nuclear Sciences Applied to Health, Coimbra, Portugal; 4IBILI - Institute for Biomedical Imaging and Life Sciences, Coimbra, Portugal 3754 — D0246 Functional Evaluation of Subretinal Space iPSC-RPE Implant In a LaserInduced RPE Injury Model In Pig. Yichao Li, J. Amaral, R. Zhou, A. Maminishkis, S. S. Miller, H. Qian, K. Bharti. National Eye Institute, Rockville, MD 3755 — D0247 Development of a custom imaging system for simultaneous monitoring of retinal and cortical physiology. Yusi Liu1, Q. Wang2, A. Rege1, S. Cunningham1, K. Raje1, H. Modi2, N. Thakor2, I. E. Zimmer-Galler3, P. L. Gehlbach3. 1Vasoptic Medical Inc., Baltimore, MD; 2 Department of Biomedical Engineering, the Johns Hopkins University, Baltimore, MD; 3The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD *CR 3756 — D0248 Functional magnetic resonance imaging as an innovative tool to assess neuroadaptation after cataract surgery. Andreia M. Rosa1, 2, Â. Miranda2, J. F. Costa1, E. A. Almeida1, F. Silva2, M. Castelo-Branco2, J. N. Murta1, 2. 1Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; 2 IBILI, Faculty of Medicine, Coimbra, Portugal 3749 — D0241 Temporal dynamics of inner retinal vasculature and oxygen extraction fraction during light flicker stimulation in humans. Anthony E. Felder, N. P. Blair, M. Shahidi. Ophthalmology & Visual Sciences, University of Illinois at Chicago, Chicago, IL f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 255 Tuesday Posters 11:00 am – 12:45 pm 3745 — D0237 Abnormal retinal venous oxygen saturation in retinal vascular disease. Sveinn H. Hardarson1, 2, T. Bek3, T. S. Eliasdottir1, 2, E. Stefansson1, 2. 1University of Iceland, Reykjavik, Iceland;2Ophthalmology, Landspitali, Reykjavik, Iceland; 3Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark *CR 3750 — D0242 Alterations in retinal tissue oxygen tension due to light flicker stimulation in rat. Norman P. Blair, M. R. Tan, A. E. Felder, P. Teng, J. Wanek, M. Shahidi. Ophthalmology and Visual Sciences, Univ of Illinois at Chicago, Chicago, IL *CR Tuesday – Workshops/SIGs Room 615/617 Room 606/607 Room 608 Tuesday, May 03, 2016 1:00 PM-2:30 PM Tuesday, May 03, 2016 1:00 PM-2:30 PM Tuesday, May 03, 2016 1:00 PM-2:30 PM Multidisciplinary Ophthalmic Imaging Group 350 Making a difference - how you can advocate your research to patients and the public using social media as an effective outreach tool 351 Identifying Your Career Options using MyIDP, ScienceCareers.org, LinkedIn & More 349 MOI Group - Intra-operative OCT The utility of intra-operative OCT has been demonstrated in both clinical and research studies for assisting ophthalmic surgical procedures. This is a rapidly evolving technology that has a significant impact on ophthalmic surgery. This MOI session provides the most updated information regarding intra-operative OCT and discusses the current limitations and future directions. Moderators: Joseph A. Izatt, Justis P. Ehlers and Zhuolin Liu — 1:00 Opening Remarks — 1:03 Integrative Advances for Intraoperative OCT Guided Ophthalmic Surgery. Yuankai Tao. Cleveland Clinic, Cleveland, OH Tuesday Workshops/SIGs 1:00 pm – 2:30 pm — 1:20 The future of ophthalmic microsurgery--guided by 4D OCT. Cynthia A. Toth. Duke Univ Eye Center, Durham, NC; Biomedical Engineering, Duke University, Durham, NC *CR, f — 1:37 Microscope-Integrated Image-Guided Ophthalmic Surgery: Clinical Evidence and New Paradigms. Justis P. Ehlers. Cleveland Clinic, Cleveland, OH *CR, f — 1:54 Future directions in intra-operative OCT development. Joseph A. Izatt. Duke University, Durham, NC *CR — 2:11 In-Situ Intraoperative OCT: Natural visual and haptic interaction with the otherwise imperceptible. John Galeotti. Robotics Institute, Carnegie Mellon University, Pittsburgh, PA; Bioengineering, University of Pittsburgh, Pittsburgh, PA *CR Communicating the importance of our vision research to the wider community is vital. Patients want to understand our latest research and find out what it might mean for them, law makers and regulators want to know what is important to people, and we want funders to continue to support our research efforts. Social media is an effective outreach tool available to many people in all walks of life. During this workshop we will explore how we could all use social media more, e.g. Twitter, to raise the profile of our vision research. Moderators: Juliet A. Moncaster and Julie T. Daniels — 1:00 Why advocacy is important: Research changes lives. Peng T. Khaw. NIHR Biomedical Research Centre, Moorfields Eye Hospital & UCL Institute of Ophthalmology, London, United Kingdom — 1:20 Advocacy group perspective. Michael Buckley. Brightfocus Foundation, USA, Clarksburg, MD — 1:40 Advocacy workshop Using social media to promote vision research. Steven M. Christiansen. Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA — 2:00 Seeing Social Clearly: How Social Media Can Be a Top Ally in Advocacy and Outreach. Heather Fernandez. Fearey Group, Seattle, WA — 2:28 Closing Remark This workshop will empower trainees to identify core skills, create career awareness and build competence in identifying career opportunities and developing strategies when searching for jobs. Members-in-training will identify their transferable knowledge and skills and practice communicating this to others. The workshop will be followed by four hours of one-on-one counseling sessions (1520 minutes each) to interested trainees. Together, the workshop and the 1-on-1 sessions will provide basic science and clinical trainees with structure and resources for exploring career paths. Sign-up for a one-on-one counseling session during the workshop. Moderators: Peter F. Hitchcock, Michael H. Elliott and Esther M. Bowie — 1:00 Looking Beyond Academia: Identifying Your Options using MyIDP, ScienceCareers.org, LinkedIn & More. Andrew Green. Career Center, UC Berkeley, Berkeley, CA Room 611/612 Tuesday, May 03, 2016 1:00 PM-2:30 PM 352 NIH-CSR Workshop on the Review of Grant Applications Sponsored by the Center for Scientific Review (CSR) at the National Institutes of Health (NIH) this workshop is designed to inform grant applicants about the NIH peer review process and also provide information about the study sections that review visual system grant applications. Scientific Review Officers (SROs) from CSR will be present for the presentation and to answer any questions. — 1:00 Introduction. Michael Chaitin. National Institutes of Health, Bethesda, MD — 1:45 Panelist. Nataliya Gordiyenko. Center for Scientific Review, National Institutes of Health, Bethesda, MD — 2:00 Panelist. Paek-Gyu Lee. Ophthalmology, Center for Scientific Review/NIH, Bethesda, MD — 2:15 Panelist. Maqsood A. Wani. Center for Scientific Review, National Institutes of Health, Bethesda, MD The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 256 Tuesday – Workshops/SIGs Room 6A Tuesday, May 03, 2016 1:00 PM-2:30 PM Retina / Clinical/Epidemiologic Research / Immunology/Microbiology / Physiology/ Pharmacology / Visual Neuroscience 353 Managing Patients with Diabetic Macular Edema, Neovascular AMD, and Retinal Vein Occlusion: How to Best Utilize Data from Clinical Trials - SIG The SIG will provide a forum for interpretation of significance of data and discussion on how results will be translated into clinical practice. There will be no rehash of data presented elsewhere at ARVO. Audience participation will be encouraged. Moderators: Peter A. Campochiaro and Diana V. Do What Is a Desired Endpoint in the Management of DME ? Quan Dong Nguyen. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE *CR Which anti-VEGF Agent Do You Use and Why? What is the Role of Corticosteroids in the Mangement of DME? Robert L. Avery. California Retina Consultants, Santa Barbara, CA *CR What Is the Role of Wide-angle Retinal Imaging in the Management of Vaso-Occlusive Diseases? David S. Boyer. Retina-Vitreous Associates Medical Group, Beverly Hills, CA *CR Room Skagit 4/5, TCC Tuesday, May 03, 2016 1:00 PM-2:30 PM Clinical/Epidemiologic Research / Glaucoma / Retina 354 Big Data and Data Visualization - Novel insights into retina disorders, glaucoma and cataract - SIG The approach to obtaining, analysing healthcare datasets will be discussed from the perspective of different countries and in different areas in ophthalmology. How data visualisation can provide novel insights beyond outcome metrics will be shown. Panelist. Anne L. Coleman. Jules Stein Eye Institue, Los Angeles, CA Room Tahoma 3, TCC Tuesday, May 03, 2016 1:00 PM-2:30 PM Panelist. Haogang Zhu. Insitiute of Ophthalmology, UCL, London, United Kingdom *CR Nanotechnology and Regenerative Medicine Group / Anatomy and Pathology/Oncology / Clinical/Epidemiologic Research / Retinal Cell Biology / Retina / Visual Neuroscience Room Tahoma 1/2, TCC 356 Integration in stem cell therapy -a challenge and a hope for vision - SIG Tuesday, May 03, 2016 1:00 PM-2:30 PM Cornea / Anatomy and Pathology/Oncology / Biochemistry/Molecular Biology / Clinical/ Epidemiologic Research / Cornea / Genetics / Glaucoma / Lens 355 Applications of Genome Editing Techniques in Biology of Anterior Segment - SIG We will explore the potentials of somatic editing techniques, e.g., CRISPR, etc. for both in vivo and in vitro experimental models for studying pathogenesis and treatment regimens of congenital and acquired anterior segment diseases. Moderators: Winston W. Kao, Kohji Nishida and Ting Xie Somatic Gene Therapy of Mucopolysaccharidosis with CRISPR/Cas9 Genome Editing. Winston W. Kao. Ophthalmology, University of Cincinnati, Cincinnati, OH Stem cell therapy offers hope for blinding diseases. This SIG will cover basic science and clincial trail of stem cell therapy for RPE, photoreceptor, and retinal ganglion cell repair, with a focus on the issue of integration of transplanted cells. Moderators: David M. Gamm and Wei Li Organizer and panelist. Zheng Qin Yin. Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing, China Panelist. Jeffrey L. Goldberg. Byers Eye Institute at Stanford University, Palo Alto, CA Panelist. Michael J. Young. 1Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, MA, 2Ocular Regenerative Medicine Institute, Harvard Medical School, Boston, MA Panelist. Jeffrey Stern. Neural Stem Cell Institute, Rensselaer, NY Panelist. Nishida. Ophthalmology, Osaka University, Osaka, Japan Panelist. Ting Xie. The Stowers Institute for Medical Research, Kansas City, MO Novel mouse models delivered by the CRISPR Express. Yueh-Chiang Hu. Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH Gene knock-in and Gene knock-out in iPS cells and primary corneal epithelial cells with CRISPR-Cas9 system. Koji Kitazawa. Ophtalmology, Kyoto Prefecture Medical University, Keoto, Japan Use of genome editing to label lineagespecific transcription factors during corneal embryogenesis in vitro. Satoshi Kawasaki. Ophthalmology, Osaka University, Osaka, Japan Moderators: Adnan Tufail and Mark C. Gillies Panelist. Aaron Y. Lee. University of Washington, Seattle, WA Panelist. David Crabb. City University, London, United Kingdom *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 257 Tuesday Workshops/SIGs 1:00 pm – 2:30 pm Do Frequent Injections of Anti-VEGF Agents Cause GA? Philip J. Rosenfeld. Bascom Palmer Eye Institute, University of Miami, Miami, FL *CR Panelist. Vincent Daien. Université de Montpellier, Montpellier, France Tuesday – All Posters Exhibit/Poster Hall Tuesday, May 03, 2016 2:45 PM-3:45 PM 359 All Posters / Networking All Posters 2:45 pm – 3:45 pm All presenters will be at their posters. The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 258 Tuesday – Papers/Minisymposium – 3759 – 3770 Room 6A Tuesday, May 03, 2016 3:45 PM-5:30 PM Glaucoma 360 Glaucoma Imaging I Moderators: Gadi Wollstein and Malik Y. Kahook 3759 — 3:45 Longitudinal reproducibility of spectral domain optical coherence tomography (SD-OCT) in children with stable glaucoma and physiological cupping. Limin Xu2, M. ElDairi1, 4, E. Silverstein5, S. Freedman1, 3. 1Pediatric Ophthalmology, Duke Eye Center, Durham, NC; 2 Duke University School of Medicine, Durham, NC; 3Glaucoma, Duke Eye Center, Durham, NC; 4 Neuro-Ophthalmology, Duke Eye Center, Durham, NC; 5Department of Ophthalmology, Virginia Commonwealth University, Richmond, VA *CR 3760 — 4:00 Reference planes for measuring of lamina cribrosa depth with optical coherence tomography. Jayme R. Vianna, V. M. Danthurebandara, G. P. Sharpe, D. Hutchison, A. Belliveau, L. Shuba, M. T. Nicolela, B. C. Chauhan. Glaucoma, Dalhousie University, Halifax, NS, Canada *CR 3762 — 4:30 Diagnostic Innovations in Glaucoma Study (DIGS): OCT Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects. Min Hee Suh1, 2, L. M. Zangwill1, A. Belghith1, A. Yarmohammadi1, P. C. Manalastas1, A. Diniz-Filho1, N. Fatehee1, S. Yousefi1, R. N. Weinreb1. 1Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, San Diego, CA; 2 Ophthalmology, Inje University Haeundae Paik Hospital, Busan, Korea (the Republic of) *CR, f 3764 — 5:00 Impact of lamina cribrosa (LC) and optic nerve head (ONH) surface deformation on visual field (VF) progression in glaucoma: A 5-year prospective study. Christopher K. Leung, Z. Wu, L. Chen. School of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong *CR 3765 — 5:15 Mitochondrial Flavoprotein Fluorescence in Glaucoma Suspects, Primary Open-Angle Glaucoma, and Healthy Controls. Lawrence Geyman1, 2, A. Pinhas3, 1, B. Krawitz1, 2, S. Mo1, 2, M. Field4, R. B. Rosen1. 1New York Eye and Ear Infirmary of Mount Sinai, New York, NY; 2Icahn School of Medicine at Mount Sinai, New York, NY; 3North Shore-LIJ Health System, Manhasset, NY; 4University of Michigan, Ann Arbor, MI *CR Room 6B Tuesday, May 03, 2016 3:45 PM-5:30 PM Retina 361 Retinal Stem Cells and Transplantation Moderator: David M. Gamm 3766 — 3:45 Generation of retinal photoreceptors from cGMP-Manufactured Human IPSC line. Jie Zhu, H. Cifuentes, J. Reynolds, D. A. Lamba. Ophthalmology, Buck Institute for Research on Aging, Novato, CA 3767 — 4:00 A novel biosynthetic RPEBrM (Retinal Pigment Epithelium-Bruch’s Membrane) assembly suitable for retinal transplantation therapy. Andrew J. Lotery1, 6, G. Ward1, 2, P. Alexander1, D. Johnston3, A. Page3, A. J. Cree1, A. Bhaskar4, S. Mahajan5, 2, M. Grossel2, J. Ratnayaka1. 1Clinical Neurosciences, University of Southampton, Southampton, United Kingdom; 2Department of Chemistry, University of Southampton, Southampton, United Kingdom; 3Biomedical Imaging Unit, University of Southampton, Southampton, United Kingdom; 4 Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom; 5Institute for Life Sciences, University of Southampton, Southampton, United Kingdom; 6 Southampton Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom 3768 — 4:15 Phase I/II clinical trial of human embryonic stem cell (hESC)-derived retinal pigmented epithelium (RPE) transplantation in Stargardt disease (STGD): One-year results. Manjit S. Mehat. UCL Institute of Ophthalmology, London, United Kingdom; NIHR Moorfields Biomedical Research Centre, London, United Kingdom f 3769 — 4:30 Transplantation of Autologous induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets for Exudative Age Related Macular Degeneration : A Pilot Clinical Study.Yasuo Kurimoto1, 2, Y. Hirami1, 2, M. Fujihara1, 2, C. Morinaga3, 1, M. Yamamoto1, 2, K. Fujita4, S. Sugita3, 1, M. Mandai3, 1, M. Takahashi3, 1. 1 Ophthalmology, Institute for Biomedical Research and Innovation Hospital, Kobe, Japan; 2 Ophthalmology, Kobe City Medical Ctr Gen Hosp, Kobe, Japan; 3Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan; 4Clinical Support Unit, Institute for Biomedical Research and Innovation Hospital, Kobe, Japan f 3770 — 4:45 Studies of Structure and Function in Whole Eye Transplantation. Kia M. Washington1, 2, Y. Li3, C. Komatsu1, M. R. Miller1, 4, Y. van der Merwe4, 5, G. Wollstein4, 5, V. L. Fu4, V. S. Gorantla1, K. C. Chan4, 5, J. S. Schuman4, 5. 1 Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA; 2VA Pittsburgh Healthcare System, Pittsburgh, PA; 3Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China; 4 Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 5Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 259 Tuesday Papers Minisymposium 3:45 pm – 5:30 pm 3761 — 4:15 Lamina cribrosa pore tortuosity in healthy and glaucomatous eyes. Bo Wang1, 2, K. Lucy1, J. S. Schuman1, 2, I. A. Sigal1, 2, R. A. Bilonick1, 3, C. D. Lu4, H. Ishikawa1, 2, L. Kagemann1, 2, J. G. Fujimoto4, G. Wollstein1, 2. 1 UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA; 3Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA; 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA *CR 3763 — 4:45 Swept-Source OCT Optic Nerve Head Structural Features of Primary Open Angle Glaucoma and Disc Hemorrhage. Sophie Cai1, M. K. Shoji1, E. Taniguchi1, D. Li1, L. A. Pereira1, 2, S. C. Brauner1, S. H. Greenstein1, A. Turalba1, L. R. Pasquale1, 3, L. Shen1. 1 Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA; 2Ministry of Education of Brazil, CAPES Foundation, Brasilia, Brazil; 3 Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA 3771 – 3786 – Tuesday – Papers/Minisymposium Room 6C Tuesday, May 03, 2016 3:45 PM-5:30 PM Retina 362 AMD Imaging Moderators: Pearse A. Keane and Robyn H. Guymer Tuesday Papers/ Minisymposium 3:45 pm – 5:30 pm 3771 — 3:45 Peripheral Retinal Abnormalities Associated with Age-Related Macular Degeneration in the Age-Related Eye Diseases Study 2 (AREDS2). Thomas R. Friberg1, A. Domalpally2, R. Danis2, T. E. Clemons3, S. R. Sadda4, C. A. Toth5, E. Y. Chew6. 1Ophthalmology and BioEngineering, Univ of Pittsburgh, Pittsburgh, PA; 2Reading Center, Univ of Wisconsin, Madison, WI; 3Emmes Corporation, Bethesda, MD; 4Doheny, Los Angeles, CA; 5Duke Eye Center, Durham, NC; 6 National Eye Institute, Bethesda, MD *CR, f 3772 — 4:00 Evaluation of intraretinal migration of retinal pigment epithelium in agerelated macular degeneration by polarization sensitive SLO and OCT. Masahiro Miura1, 2, S. Sugiyama3, 5, A. E. Elsner4, S. Makita5, Y. Hong5, Y. Yasuno5, T. Iwasaki1, 2, H. Goto2. 1Tokyo Medical University, Ibaraki Medical Center, Ophthalmology, Ami, Japan; 2Tokyo Medical University, Ophthalmology, Tokyo, Japan; 3Tomey Corp, Nagoya, Japan; 4School of Optometry, Indiana University, Bloomingtom, IN; 5Computational Optics Group, Univ of Tsukuba, Tsukuba, Japan *CR 3773 — 4:15 Evaluating choroidal pigmentation in the setting of polypoidal choroidal vasculopathy in a Caucasian population. Talia R. Kaden1, A. C. Tan2, F. Gilani2, S. Zahid1, L. Yannuzzi2. 1Ophthalmology, New York University, New York, NY; 2Vitreous Retina Macula (VRM) Consultants, New York, NY 3774 — 4:30 Autofluorescent (AF) sub-retinal pigment epithelium (sub-RPE) deposits in agerelated macular degeneration (AMD) accumulate preferentially at the fovea. Thomas Ach1, 3, J. S. Koplon3, C. E. Huisingh3, J. D. Messinger3, A. V. Zarubina3, K. R. Sloan2, C. A. Curcio3. 1Department of Ophthalmology, University Hospital Wuerzburg, Wuerzburg, Germany; 2Computer and Information Sciences, University of Alabama at Birmingham, Birmingham, AL; 3Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL *CR 3775 — 4:45 Histological stages of subretinal drusenoid deposits (SDD) in eyes with agerelated macular degeneration (AMD). Christine A. Curcio1, J. D. Messinger1, Y. Zhang1, D. Neely1, K. Freund2, 3, R. F. Spaide2, 3. 1Ophthalmology, Univ of Alabama at Birmingham, Birmingham, AL; 2 Vitreous Retina Macula Consultants of New York, New York, NY; 3LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital Manhattan Eye, Ear, and Throat Hospital, New York, NY *CR 3781 — 4:30 Loss of human corneal epithelial cell identity exhibited by deletion of PAX6 using the CRISPR/Cas9 system. Koji Kitazawa1, 2, T. Hikichi2, T. Nakamura3, C. Sotozono1, S. Kinoshita3, S. Masui2, 4. 1Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Center for iPS Cell Research & Application, Kyoto, Japan; 3 Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4CREST, Tokyo, Japan *CR 3776 — 5:00 Fully Automated Identification of Lesion Activity in Neovascular AMD. Anat Loewenstein1, D. Goldenberg1, U. Chakravarthy2, G. Young3, M. Havilio3, O. Rafaeli3, G. Benyamini3.1Ophthalmology, Tel Aviv Medical Center, Tel Aviv, Israel; 2Queen’s University, Center for Experimental Medicine, Belfast, Ireland; 3Notal Vision, Tel Aviv, Israel *CR 3782 — 4:45 Small Wnt Inhibitors Modulate the Expansion of Limbal Stem/Progenitor Cells in vitro. Hua Mei, C. Zhang, E. R. Baclagon, J. J. Zheng, S. X. Deng. Department of Ophthalmology, Jules Stein Eye Institute, UCLA, Los Angeles, CA 3777 — 5:15 Automated identification and quantification of subretinal fibrosis in neovascular age-related macular degeneration using polarization-sensitive optical coherence tomography. Philipp K. Roberts2, M. Sugita1, G. Dèak2, B. Baumann1, S. Zotter1, M. Pircher1, S. Sacu2, C. K. Hitzenberger1, U. Schmidt-Erfurth2. 1 Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria; 2Department of Ophthalmology, Medical University of Vienna, Vienna, Austria *CR Room 606/607 Tuesday, May 03, 2016 3:45 PM-5:30 PM Cornea 363 Corneal cell and molecular biology and imaging Moderators: Sophie X. Deng, Che J. Connon and Friedrich E. Kruse 3778 — 3:45 Limbal Stem Cells Activate Autophagy to Recruit Ocular Master Regulator PAX6 in Cellular Stress Response to Ultraviolet A Radiation. Maria Laggner, A. Pollreisz, G. Schmidinger, U. Schmidt-Erfurth, Y. Chen. Ophthalmology, Medical University of Vienna, General Hospital of Vienna, Vienna, Austria 3779 — 4:00 Autophagy, a protective factor in limbal epithelium, is positively regulated by a microRNA family. Han Peng1, J. Kook1, J. Katsnelson2, W. Yang1, C. He1, R. M. Lavker1. 1 Northwestern University, Chicago, IL; 2Rush Medical College, Chicago, IL 3780 — 4:15 Screening apoptosis markers in human corneal endothelium and epithelium. Siddharth Mahajan, D. Thieme, F. E. Kruse, T. A. Fuchsluger. Department of Ophthalmology, University of Erlangen-Nurnberg, Erlangen, Germany 3783 — 5:00 Bowman’s Layer Acoustic Impedance in Normal and Keratoconus Corneas. Ronald H. Silverman1, 2, R. Urs1, H. O. Lloyd1, T. J. Archer3, M. Gobbe3, D. Z. Reinstein3, 1. 1 Ophthalmology, Columbia University Medical Center, New York, NY; 2F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY; 3London Vision Clinic, London, United Kingdom *CR 3784 — 5:15 Potential Of High Resolution Gabor-Domain Optical Coherence Microscopy For Early Diagnosis Of Corneal Disease. Patrice Tankam1, Z. He2, G. Thuret2, H. B. Hindman1, T. Lepine2, P. Gain2, J. P. Rolland-Thompson1. 1 Ophthalmology, University of Rochester, Rochester, NY; 2Universite Jean Monnet, Saint Etienne, France Room 608 Tuesday, May 03, 2016 3:45 PM-5:30 PM Anatomy and Pathology/Oncology 364 Novel signaling mechanisms in refractive development Moderators: Thomas T. Norton and Xiaoying Zhu 3785 — 3:45 Crystalline lens thickness is modulated by spectacle lens defocus in chicks. Sally A. McFadden1, N. Bilton2, 1, S. Harrison1, M. H. Howlett3, 1. 1Psychology, University of Newcastle, Callaghan, NSW, Australia; 2School of Biomedical Sciences, Charles Sturt University, Port Macquarie, NSW, Australia; 3Netherlands Institute for Neuroscience, Amsterdam, Netherlands 3786 — 4:00 Investigation of the role of ZNF644 in emmetropization and refractive error using zebrafish. Ross F. Collery1, T. L. Young2, B. Link1. 1Medical College of Wisconsin, Milwaukee, WI;2Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 260 Tuesday – Papers/Minisymposium – 3787 – 3807 3787 — 4:15 Ascorbic acid, and not L-DOPA, protects against form-deprivation myopia in retinal degeneration mouse models. Erica Landis1, 2, H. Park1, R. Chakraborty1, C. Sidhu1, P. Iuvone1, 5, M. T. Pardue3, 4. 1Ophthalmology, Emory University, Atlanta, GA; 2Neuroscience, Emory University, Atlanta, GA; 3Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 4Center for Visual and Neurocognitive Rehabilitation, Veterans Affairs Medical Center, Atlanta, GA; 5Pharmacology, Emory University, Atlanta, GA 3788 — 4:30 Intrinsic Ocular Mechanisms Underlie Lens-Induced Astigmatism in Chicks. William K. Stell1, V. Popa1, C. Kee2. 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;2School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong 3789 — 4:45 Origin of different responses to myopia-inducing stimuli in two guinea pig strains. Liqin Jiang, S. Kochik, Y. Shen, C. F. Wildsoet. Ophthalmology and Visual Sciences, School of Optometry, UC Berkeley, Berkeley, CA 3790 — 5:00 Visually Regulated Gene Expression of Apolipoprotein A-1 in Chick Eyes. Jody A. Summers Rada, A. Harper, J. Moore. Cell Biology, University of Oklahoma Health Science Center, Oklahoma City, OK 3795 — 4:30 The molecular basis of crystallin gene expresssion in lens: Role of FGF signaling and c-MAF. Ales Cvekl1, Q. Xie1, R. McGreal1, R. Harris1, S. Limi1, C. Gao4, W. Liu1, L. W. Reneker2, L. Musil3. 1Albert Einstein Coll of Medicine, Bronx, NY; 2University of Missouri, Columbia, MO; 3 Oregon Health Science University, Portland, OR; 4 National Eye Institute, Bethesda, MD 3796 — 4:45 Gene Expression in Single Fiber Cells of the Ocular Lens: A window into molecular heterogeneity in a functional tissue. Suraj P. Bhat1, 2, R. K. Gangalum1, D. Mock1. 1Jules Stein Eye Institute UCLA, Los Angeles, CA; 2 Molecular Biology Institute and Brain Research Institute, UCLA, Los Angeles, CA 3797 — 5:00 Lens differentiation rides the wave of p27Kip1 to lens fiber cell denucleation. Allen Taylor1, S. Rowan1, M. Chang1, F. Shang1, N. Reznikov2, L. Lyu1, 3, K. Liu1, 3. 1Tufts University, Boston, MA;2Department of Materials, Imperial College, London, United Kingdom; 3Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu, China 3798 — 5:15 Characterization of Lens Fiber Cell Membrane Microdomains by Proteomics Analysis of Lipid Rafts. Vasanth Rao, R. Pratheepa kumari, N. Skiba. Opthalmology, Duke University, Durham, NC Tuesday, May 03, 2016 3:45 PM-5:30 PM Lens 365 Lens fiber cell biology Moderators: Velia M. Fowler and Michael L. Robinson 3792 — 3:45 Beta1 integrin is a negative regulator of lens epithelial to fiber cell differentiation in the early lens. Melinda K. Duncan, M. Pathania, Y. Wang. Biological Sciences, University of Delaware, Newark, DE *CR 3793 — 4:00 A Critical Role for N-cadherin in Lens Fiber Cell Migration along the EFI for Lens Morphogenesis. Caitlin Logan1, S. Rajakaruna1, G. Radice1, M. L. Robinson2, A. Menko1, 3. 1Pathology Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA; 2 Miami University, Oxford, OH; 3Wills Vision Research Center at Jefferson, Philadelphia, PA 3803 — 4:45 Stereoscopic acuity as a function of induced monocular defocus measured with an adaptive optics simulator. Silvestre Manzanera1, A. Alarcon2, C. Canovas2, P. Prieto1, A. Gambin1, H. A. Weeber2, P. A. Piers2, P. Artal1. 1Laboratorio de Optica, University of Murcia, Murcia, Spain; 2 AMO, Groningen, Netherlands *CR 3804 — 5:00 Neural Binocular Summation Altered by Abnormal Interocular Disparities in Normally Developed Visual Systems. Robert Dowd1, A. Barbot1, 3, G. Yoon1, 2, K. R. Huxlin1, 3, D. Tadin3. 1Flaum Eye Institute, University of Rochester, Rochester, NY; 2Biomedical Engineering, University of Rochester, Rochester, NY; 3CVS Department, University of Rochester, Rochester, NY 3805 — 5:15 Improving vision by pupil shape optimization. Sergio Bonaque-González1, 2, N. Lopez-Gil2, S. Rios1. 1Universidad de La Laguna, Santa Cruz de Tenerife, Spain; 2Grupo de Ciencias de la Vision, Universidad de Murcia, Murcia, Spain *CR Room 615/617 Tuesday, May 03, 2016 3:45 PM-5:30 PM Room 611/612 Room 609 3802 — 4:30 Through-focus binocular contrast sensitivity of monofocal and multifocal intraocular lens predicted by an adaptive optics visual simulator. Aixa Alarcon1, C. Canovas1, S. Manzanera2, P. Prieto2, K. Hileman3, P. A. Piers1, P. Artal2. 1Abbott Medical Optics, Groningen, Netherlands; 2Laboratorio de Optica, Universidad de Murcia, Murcia, Spain; 3Abbott Medical Optics, Santa Ana, CA *CR Glaucoma Tuesday, May 03, 2016 3:45 PM-5:30 PM Visual Psychophysics/Physiological Optics 367 Trabecular Meshwork and Aqueous Humor Dynamics 366 Optical imaging, adaptive optics and vision Moderators: Haiyan Gong and Ted S. Acott Moderators: Nancy J. Coletta and Alberto De Castro 3799 — 3:45 Dominant role of arachidonic acid pathways in light-activated rod-induced neurovascular response accessed by retinal optical imaging. Daniel Y. Tso, M. Begum. Neurosurgery/Neuroscience/Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 3800 — 4:00 A Programmable Aperture Adaptive Optics SLO. Stephen A. Burns, A. De Castro, L. Sawides, T. Luo. School of Optometry, Bloomington, IN 3801 — 4:15 Magnification Characteristics on Optical Coherence Tomography Systems. Dirk-Uwe G. Bartsch. Ophthalmology, Univ of California-San Diego, La Jolla, CA *CR 3806 — 3:45 Investigation of the two types of cellular connections of Schlemm’s canal inner wall cells and their role in giant vacuole and pore formation by serial block-face scanning electron microscopy.Julia Lai1, 2, D. Getchevski1, A. Zavras1, D. Huang1, S. Srikumar1, H. Gong1, 2. 1Ophthalmology, Boston University School of Medicine, Boston, MA; 2Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 3807 — 4:00 Crosstalk between TGFβ2 and TLR4 in the trabecular meshwork. Colleen M. McDowell, H. Hernandez, A. F. Clark. North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 261 Tuesday Papers Minisymposium 3:45 pm – 5:30 pm 3791 — 5:15 Non-visual factors influencing emmetropization in chicks. Xiaoying Zhu2, 1, J. Wallman3, S. A. McFadden2. 1Biology and Vision Sciences, SUNY College of Optometry, New York, NY; 2School of Psychology, University of Newcastle, Callaghan, NSW, Australia; 3Biology, City College of New York, New York, NY 3794 — 4:15 Analysis of FGFR2 Regulated Transcripts in the Newborn Mouse Lens. Michael L. Robinson, S. L. Padula, T. Hoang, L. Liu, C. Liang. Biology, Miami University, Oxford, OH 3808 – 3824 – Tuesday – Papers/Minisymposium 3808 — 4:15 Schlemm Canal (SC) Response to Elevated Intraocular Pressure (IOP) Varies with Morphologic Phenotype. Larry Kagemann1, 2, G. Wollstein1, H. Ishikawa1, 2, I. A. Sigal1, 2, J. S. Schuman1, 2. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA *CR 3809 — 4:30 A role for exosomes in steroid induced ECM accumulation in the TM. W. Michael Dismuke, W. D. Stamer. Duke University, Durham, NC 3810 — 4:45 The role of VEGF on outflow facility in mice with glucocorticoid-induced ocular hypertension. Ester Reina-Torres, J. M. Sherwood, D. R. Overby. Bioengineering, Imperial College London, London, United Kingdom Tuesday Papers/ Minisymposium 3:45 pm – 5:30 pm 3811 — 5:00 The Role of Growth Differentiation Factor-15 in Regulation of Contractile Properties of Human Trabecular Meshwork Cells. Arumugam Ramachandran Muralidharan1, R. Maddala1, V. Rao1, 2. 1 Ophthalmology, Duke University Medical Center, Durham, NC; 2Pharmacology, Duke University School of Medicine, Durham, NC 3812 — 5:15 Human Adipose-derived Stem Cells Integrate into Normal Mouse Trabecular Meshwork. Yi Zhou1, 2, H. Yun1, E. Yang1, X. Xia2, J. S. Schuman1, 3, Y. Du1, 3. 1Ophthalmology, University of Pittsburgh, Pittsburgh, PA; 2Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; 3Ophthalmology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA Room 618/620 Tuesday, May 03, 2016 3:45 PM-5:30 PM Eye Movements/Strabismus/Amblyopia/NeuroOphthalmology 368 Amblyopia Moderators: Irene Gottlob, Huibert J. Simonsz and Susan M. Culican 3813 — 3:45 High heterogeneity in the receptive-field subunit maps of multiple nearby neurons in infant V2. Bin Zhang1, 2, X. Tao2, G. Shen2, J. M. Wensveen2, E. L. Smith2, Y. M. Chino2. 1Optometry, Nova Southeastern University, Plantation, FL; 2Optometry, University of Houston, Houston, TX 3814 — 4:00 Disconnection of ipsilateral FEF from the attention network in strabismic amblyopia during coherent motion task. Sheila G. Crewther1, H. Wang2, M. Liang3, T. Yu2, J. Wang3, D. P. Crewther4, R. Laycock1, Z. Yin2. 1School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia; 2Key Laboratory of Visual Damage and Regeneration and Restoration of Chongqing, Southwest Eye Hospital, Southwest Hospital,Third Military Medical University, Chongqing, China; 3Department of Radiology, Third Military Medical University, Chongqing, China; 4Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC, Australia 3815 — 4:15 Binocular Interactions during Rapid Alternating Occlusion as measured with Visual Evoked Potentials. Hilary A. Hamer1, A. McLeod2, A. Panorgias1. 1Vision Science, New England College of Optometry, Malden, MA; 2 Specialty and Advanced Care, New England College of Optometry, Boston, MA 3816 — 4:30 Home use binocular dichoptic video content treatment for amblyopia-pilot study. chaim Stolovitch. Ophthalmology, Tel Aviv Medical center, Tel Aviv, Israel f 3817 — 4:45 Greater eye movement disconjugacy with near fixation in amblyopia during binocular viewing is associated with increased microsaccade rate. Howard S. Ying1, S. Rhiu3, 1, C. Yang1, V. Xu2, R. Geary2, B. I. Gramatikov2, D. L. Guyton2, K. Irsch2. 1Ophthal & Visual Sciences, Boston University School of Medicine, Boston, MA; 2Ophthalmology, The Johns Hopkins University, Baltimore, MD; 3 Ophthalmology, Hallym University College of Medicine, Hwaseong, Korea (the Republic of) *CR 3818 — 5:00 Disinvestment of populationwide eye screening at age 6-24 months in the Netherlands. Frea Sloot1, H. Karaman1, 2, A. Sami1, 2, S. E. Loudon1, J. Benjamins3, H. J. Simonsz1. 1Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands; 2Orthoptics, University of Applied Sciences, Utrecht, Netherlands; 3Public Health Service Icare, Meppel, Netherlands f 3819 — 5:15 Detection of Amblyopia in Young Children via Retinal Rivalry Using a Video Game Styled Interface on a Tablet Device. Ryan Gise1, S. Kane2. 1Ophthalmology, Albert Einstein College of Medicine/ Montefiore Medical Center, New York, NY; 2Ophthalmology, Columbia University Medical Center, New York, NY Room Skagit 4/5, TCC Tuesday, May 03, 2016 3:45 PM-5:30 PM Immunology/Microbiology 369 Microbiology / Immunology / Translational / Innate immunity Moderator: Lucy H. Young 3820 — 3:45 Phenotypic and functional characterization of intraocular T cell response in intraocular tuberculosis. Soumyava Basu1, 2, R. Tagirasa3, M. Barik1, 2, S. Devadas3. 1Retina and Uveitis, LV Prasad Eye Institute, Bhubaneswar, India; 2Prof Brien Holden Eye Research Institute, Bhubaneswar, India; 3Institute of Life Sciences, Bhubaneswar, India f 3821 — 4:00 Thrombospondin-derived peptide attenuates Sjögren’s syndrome-associated ocular surface inflammation. Laura Contreras-Ruiz1, F. A. Mir2, B. Turpie1, S. Masli1. 1Department of Ophthalmology, Boston University School of Medicine, Boston, MA; 2Hamad Medical Corporation, iTRI, Doha, Qatar *CR 3822 — 4:15 Identifying the mechanism of NF-kB activation by Toxoplasma gondii’s strain II dense granule GRA15 (GRA15 (II)). Eleni Konstantinou1, N. Yang3, J. P. Saeij2, L. H. Young1. 1Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; 2The department of Pathology, Microbiology & Immunology at, The University of California, Davis, CA; 3Singapore Institute for Clinical Sciences, Singapore, Singapore 3823 — 4:30 Rose bengal-mediated photodynamic antimicrobial therapy to inhibit Pseudomonas aeruginosa isolates in agar plates and contaminated contact lens cases. Heather A. Durkee1, N. Relhan1, A. Arboleda1, M. C. Aguilar1, K. A. Alawa1, F. Halili1, C. Rowaan1, G. Amescua2, H. W. Flynn2, D. Miller3, J. A. Parel1, 4. 1Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Anne Bates Leach Eye Hospital, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 3 Ocular Microbiology Laboratory, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 4CHU Sart-Tillman, Department of Ophthalmology, University of Liege, Liege, Belgium 3824 — 4:45 Contrary effects of Interleukin-1 receptor antagonist (Ra) and IL-36Ra on corneal innate immune defense against Pseudomonas aeruginosa keratitis. Nan Gao1, F. X. Yu1, T. Standiford2.1Wayne State Univ/Kresge Eye Inst, Detroit, MI; 2Pulmonary and Critical Care Medicine, Ann Arbor, MI The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 262 Tuesday – Papers/Minisymposium – 3825 – 3841 3825 — 5:00 TLR2 and ALX/FPR2 receptor “cross talk” is essential for Resolvin D1 (RvD1)mediated inflammation resolution and protection in Staphylococcus aureus endophthalmitis. Pawan Kumar Singh1, 2, A. Kumar1, A. Kumar1, 2. 1Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI; 2Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 3826 — 5:15 A Novel Pollen/TLR4 Concept, an Innate Immunity Signaling Initiating IL33/ST2 Pathways in Th2-dominant Allergic Inflammation. De-Quan Li1, J. LI1, 2, L. Zhang1, X. Chen1, 2, S. C. Pflugfelder1, X. Hua1, F. Bian1. 1 Ophthalmology, Baylor College of Medicine, Houston, TX; 2School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China Room Tahoma 1/2, TCC Tuesday, May 03, 2016 3:45 PM-5:30 PM Retinal Cell Biology 370 Retinal Development II: Cell differentiation and determination Moderators: Luca Della Santina and Andrew J. Fischer 3828 — 4:00 Tet2 and Tet3 methylcytosine dioxygenases are required for retinal neurogenesis during zebrafish eye development. Jeffrey M. Gross, P. Seritrakul. Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 3829 — 4:15 The microRNA miR-18a regulates NeuroD and photoreceptor differentiation. Scott M. Taylor, P. F. Hitchcock. Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 3830 — 4:30 Type 4 cone bipolar cell dendrite morphology is maintained by DSCAM and BAX in the adult mouse retina. Aaron B. Simmons1, S. Bloomsburg1, D. Briggs1, J. Hix3, E. Pecor3, S. Billingslea1, J. Young1, P. G. Fuerst1, 2. 1Biological Sciences, University of Idaho, Moscow, ID; 2 WWAMI Medical Education Program, University of Idaho, Moscow, ID; 3North Idaho College, Coeur d’Alene, ID 3832 — 5:00 Reelin and Synaptic Genes are Enriched in GCL Transcriptome during Early Inner Plexiform Layer Development. Steve T. Huynh1, D. M. Sherry4, P. Gunaratne2, 3, D. C. Otteson1, 3. 1College of Optometry, University of Houston, Houston, TX; 2Baylor College of Medicine, Houston, TX; 3Department of Biology, University of Houston, Houston, TX; 4Health Sciences Center, University of Oklahoma, Oklahoma CIty, OK 3833 — 5:15 The role of Satb2 in establishing Direction-Selective Retinal Ganglion Cell identity in the mouse retina. Andreea Nistorica, N. Sweeney, D. Feldheim. MCDB, University of California Santa Cruz, Santa Cruz, CA Room Tahoma 3, TCC Tuesday, May 03, 2016 3:45 PM-5:30 PM Clinical/Epidemiologic Research 371 A wide view on Glaucoma epidemiology Moderators: Paul R. Healey and Andrew J. Tatham 3834 — 3:45 Twelve years incidence of open-angle glaucoma in the Thessaloniki Eye Study. Fotis Topouzis1, M. Wilson2, A. Harris3, P. Founti1, 4, F. Yu5, 6, T. Pappas1, E. Anastasopoulos1, A. Salonikiou1, V. Kilintzis1, A. L. Coleman5, 7. 1Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece; 2Wayne State University, Detroit, MI; 3Indiana University School of Medicine, Indianapolis, IN; 4Moorfields Eye Hospital, London, United Kingdom; 5Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA; 6Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA; 7Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, CA *CR 3835 — 4:00 Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women. Jae H. Kang2, J. L. Wiggs1, L. R. Pasquale1, 2. 1Department of Ophthalmology, Brigham and Women’s Hospital, Boston, MA; 2Medicine, Brigham and Women’s Hospital / Harvard Medical School, Boston, MA 3836 — 4:15 Evaluation of activity-normalized fall rates in glaucoma. Pradeep Y. Ramulu, A. Mihailovic, S. K. West, D. S. Friedman. Wilmer Eye Inst/Johns Hopkins, Baltimore, MD *CR 3837 — 4:30 Association between Glaucoma Progression and Medication Adherence: 7-Year Study of Veterans Affairs Maryland Health Care System Database. Eva DeVience1, S. DeVience2, K. Williams1, M. V. Boland3, L. Im1, R. Ballinger4, D. S. Friedman5, O. Saeedi1. 1Department of Ophthalmology, University of Maryland, Baltimore, MD; 2University of Maryland, Baltimore, MD; 3 Wilmer Eye Institute and Health Sciences Informatics, Baltimore, MD; 4VA Maryland Health Care System, Baltimore, MD; 5Wilmer Eye Institute, Baltimore, MD 3838 — 4:45 Cost-effectiveness analysis of following patients with glaucoma. Vishva M. Danthurebandara, J. R. Vianna, G. P. Sharpe, D. Hutchison, A. Belliveau, L. Shuba, M. T. Nicolela, B. C. Chauhan. Ophthalmology and Visual Sciences, Dalhousie University, Halfax, NS, Canada *CR 3839 — 5:00 Cost-utility analysis of cataract extraction by phacoemulsification versus combined phacotrabeculectomy in treating chronic angle closure glaucoma (CACG) with coexisting cataract. Xiaofei MAN. Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China 3840 — 5:15 Driving Performance in Subjects with Glaucomatous Visual Field Loss as Investigated in a Driving Simulator. Amir Marvasti, A. Diniz-Filho, E. R. Boer, P. Rosen, F. A. Medeiros. Shiley Eye Institute, University of California, San Diego, San Diego, CA *CR Room Tahoma 4, TCC Tuesday, May 03, 2016 3:45 PM-5:30 PM Biochemistry/Molecular Biology 372 Photoreceptor degeneration and phototransduction Moderators: Michael Redmond, Radha Ayyagari and Christian Grimm 3841 — 3:45 ARL2BP is essential for the function of rod and cone photoreceptor cells. Abigail R. Hayes1, 2, R. Singh2, V. Ramamurthy1, 2. 1 Biochemistry, West Virginia University, Morgantown, WV;2Ophthalmology, West Virginia University, Morgantown, WV f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 263 Tuesday Papers Minisymposium 3:45 pm – 5:30 pm 3827 — 3:45 Laminin β2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation. Dmitri Serjanov, G. bachay, D. D. Hunter, W. J. Brunken. Ophthalmology, Upstate Medical University, Syracuse, NY 3831 — 4:45 Ccnd1-Cdk4 stimulates Müller glia cell cycle re-entry in the mouse retina. Sheik Pran Babu Sardar Pasha1, 2, F. Calegari3, M. Karl1, 2. 1Retinal Regeneration and Degeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) in der HelmholtzGemeinschaft, Dresden, Germany; 2Retinal Development & Regeneration, Technische Universität Dresden,DFG-Center for Regenerative Therapies Dresden & Cluster of Excellence, Dresden, Germany; 3Neural Stem Cells in the Mammalian Brain, Technische Universität Dresden, DFG-Center for Regenerative Therapies Dresden (CRTD)& Cluster of Excellence, Dresden, Germany 3842 – 3852 – Tuesday – Papers/Minisymposium 3842 — 4:00 Trafficking of transducin-α by UNC119A/B and ARL3GTP dependent diffusion. Wolfgang Baehr, C. D. gerstner, C. HankeGogokhia, G. ying, J. M. Frederick. Ophthalmology, Univ of Utah Sch of Med, Salt Lake City, UT 3843 — 4:15 The Role of Circadian Rhythms in Regulating the Cone Phototransduction Cascade Shutoff in Zebrafish Retina. Stephan C. Neuhauss, J. Keim, J. Zang. Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland 3844 — 4:30 Posttranslational Lipid Modification Controls the Trafficking of Transducin to the Photoreceptor Cilium. Maxim Sokolov, M. Belcastro, J. Murphy, S. Kolandaivelu. Ophthalmology, West Virginia Univ Eye Institute, Morgantown, WV Tuesday Papers/ Minisymposium 3:45 pm – 5:30 pm 3845 — 4:45 Ablation of Retbindin Alters Flavin Levels and Leads to Rod and Cone Photoreceptor Degeneration. Muayyad R. Al-Ubaidi1, R. Kelley2, J. Du3, J. Hurley4, M. I. Naash1. 1Biomedical Engineering, University of Houston, Houston, TX; 2Cell Biology, University of Oklahoma, Oklahoma city, OK; 3Ophthalmology, University of Washington, Seattle, WA; 4 Biochemistry, University of Washington, Seattle, WA 3846 — 5:00 Design, generation, and initial characterization of gene-edited mice for the analysis of the peripherin-2/rds (P/rds) cytoplasmic C-terminal domain. Andrew F. Goldberg1, B. Cavanaugh1, M. L. Milstein1, V. A. Kimler1, K. P. Mitton1, T. Saunders2. 1Eye Research Institute, Oakland University, Rochester, MI; 2 Transgenic Animal Model Core, University of Michigan, Ann Arbor, MI 3847 — 5:15 Long-term treatment with 9-cisβ-carotene rich alga Dunaliella Bardawil inhibits photoreceptor degeneration in a mouse model of retinoid cycle defect. Ifat Sher1, 2, V. Edelshtain1, 2, A. Tzameret1, 2, D. Harats3, A. Shaish3, Y. Rotenstreich1, 2. 1Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Israel; 2Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; 3The Bert W. Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel Room Tahoma 5, TCC Tuesday, May 03, 2016 3:45 PM-5:30 PM Visual Neuroscience 373 Connecting the retina to the brain: The mouse - Minisymposium The advent of powerful molecular tools available in the mouse has seen many investigators shift their focus to this animal model. This minisymposium highlights recent studies in the mouse that advance understanding of the function and diversity of retinal ganglion cells, the connections from the retinal ganglion cells to high visual areas, and the organization of the central visual targets. The speakers will be asked to compare the mouse model with other larger animal models where similar earlier studies have been performed. Moderators: William R. Taylor and Scott A. Nawy 3848 — 3:45 What the mouse eye tells the mouse’s brain: a functional classification of retinal ganglion cells. Tom Baden. Bernstein Centre for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany; Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany 3849 — 4:05 Multiple synaptic mechanisms underlying direction selectivity in the mouse retina. Wei Wei. University of Chicago, Chicago, IL 3850 — 4:25 New roles for intrinsically photosensitive retinal ganglion cells. Tiffany Schmidt. Neurobiology, Northwestern University, Evanston, IL 3851 — 4:45 Direction Selectivity in the Mouse Superior Colliculus. Jianhua Cang. Northwestern University, Evanston, IL 3852 — 5:05 Visual processing in the mouse thalamocortical pathway. Cristopher Niell. Biology Dept / Institute of Neuroscience, University of Oregon, Eugene, OR — 5:25 Discussion The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 264 Tuesday – Posters – 3853 – 3874 Exhibit/Poster Hall A0001-A0044 Tuesday, May 03, 2016 3:45 PM-5:30 PM Cornea 374 Ocular Surface Health and Disease Moderator: Noriko Koizumi 3853 — A0001 APR-246/PRIMA-1Met inhibits and reverses squamous metaplasia in human conjunctival epithelium. Cheng Li, W. Li, Z. LIU, J. Li. Ophthalmology and Visual Sciences, Eye Inst & Affiliated Xiamen Eye Ctr, Xiamen, China 3854 — A0002 The Effect of Betadine on Vision. Caren Oquindo1, W. H. Ridder1, K. Dhamdhere2, J. A. Burke2. 1Southern California College of Optometry, Marshall B. Ketchum University, Fullerton, CA; 2Allergan, Inc., Irvine, CA *CR 3855 — A0003 The Effect of Betadine on Vision and on Cornea in Rabbits. Kavita Dhamdhere, A. S. Almazan, M. Engles, J. A. Burke. Allergan Inc, Irvine, CA 3856 — A0004 Hoxc8 misexpression prevents embryonic eyelid fusion and transforms cornea and conjunctiva into keratinized skin. Lara S. Carroll. Moran Eye Center, University of Utah, Salt Lake City, UT 3858 — A0006 IKZF1 Expression and Upregulation by polyI:C in Human Ocular Surface Epithelial Cells. Mayumi Ueta1, H. Nishigaki1, K. Shinomiya2, N. Yokoi2, C. Sotozono2, S. Kinoshita1. 1Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2 Department of Opthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan 3859 — A0007 Ocular Surface Adverse Events of Systemic Inhibitors of the Epidermal Growth Factor Receptor (EGFRi): a Prospective Trial. Alejandro Saint-Jean1, 2, A. Eixarch2, N. Reguart4, N. Pardo4, C. Castella2, 3, M. Sainz De La Maza2, A. Adan Civera2, B. Sanchez Dalmau2, M. Aldea5, R. Torres2. 1Ophthalmology, CHU Nantes, Nantes, France; 2Ophthalmology, Hospital Clinic Barcelona, Barcelona, Spain; 3Clinique Sourdille, Nantes, France; 4Oncology Department, Hospital Clinic, Barcelona, Spain; 5Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institute of Oncology, IDIBELL, Barcelona, Spain f 3861 — A0009 PROSE lens use for exposure keratopathy in trigeminal and facial nerve palsies. Elizabeth Marlow, J. Ciralsky, M. Lee, G. Lelli. Ophthalmology, Weill Cornell Medical College, New York, NY 3862 — A0010 Impact of conjunctival autograft on pterygium treatment: evaluation of related symptoms and patients satisfaction after surgery. Bruna Duarte Moron de Andrade, G. Capecci Siqueira, P. Dechichi Neto, A. Terra Baccega, M. Gonçalves Monteiro Viturino, A. Mylla Boso, D. de Paiva Almeida, M. Alves. Department of Ophthalmology, UNICAMP, Campinas, Brazil 3863 — A0011 Correlation between Meibomian Gland Dysfunction and Keratitis in Patients with Demodex Brevis Infestation. Lingyi Liang1, H. Ke1, S. C. Tseng2. 1Cornea, Zhongshan Ophthalmic Center, Guangzhou, China; 2Ocular Surface Research and Education Center, Miami, FL *CR 3864 — A0012 The Evaluation of Worldwide Distribution of Adenoviral Genotypes in Acute/ Epidemic Keratoconjunctivitis and Adenoviralnegative Keratoconjunctivitis with Next Generation Sequencing.Cecilia S. Lee1, A. Y. Lee1, L. Akileswaran1, D. W. Stroman2, K. NajafiTagol2, S. Kleiboeker4, A. Wald3, R. N. Van Gelder1. 1 Ophthalmology, University of Washington, Seattle, WA; 2NovaBay Pharmaceuticals, Inc., Emeryville, CA; 3Infectious Diseases, University of Washington, Seattle, WA; 4ViraCor-IBT Laboratories, Inc, Lee’s Summit, MO *CR, f 3865 — A0013 Safety and efficacy study to evaluate wiping the lid margins with tap water alone or in combination with lid hygiene shampoo in subjects with normal meibomian glands. Hirotaka Tanabe, M. Kaido, M. Kawashima, R. Ishida, K. Tsubota. Ophthalmology, Keio Univ School of Medicine, Tokyo, Japan *CR, f 3866 — A0014 Histatin-1 as a peptide based therapy for human corneal epithelial wound healing. Dhara Shah, Z. Pasha, M. Ali, V. K. Aakalu. Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL 3867 — A0015 Non-invasive technique for dynamic measurement of tear film surface quality based on interferometry. Dorota H. Szczesna-Iskander, S. Drobczynski. Dept. of Optics and Photonics, Wroclaw University of Technology, Wroclaw, Poland 3868 — A0016 Stimulation of Corneal Nociceptors Results in Pro-inflammatory Molecular and Cellular Responses. Yashar SeyedRazavi1, 2, P. Hamrah3, 4. 1Ophthalmology, Tufts Medical Center, Boston, MA;2Ophthalmology, Schepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, MA; 3 Ophthalmology, Schepens Eye Research Institute/ Massachusetts Eye and Ear, Cornea & Refractive Surgery Service, Harvard Medical School, Boston, MA; 4Ophthalmology, Cornea Service, New England Eye Center, Tufts Medical Center, Boston, MA 3869 — A0017 Crosstalk Between Selective Autophagy and Nrf2-ARE Pathway Through p62/SQSTM1 Confers Limbal Stem Cell Resistance to Ultraviolet-A Irradiation. Ying-Ting Chen1, M. Laggner1, F. Gruber2, E. Tschachler2, U. Schmidt-Erfurth1, A. Pollreisz1. 1Department of Ophthalmology, Medical University of Vienna, Vienna, Austria; 2Department of Dermatology, Medical University of Vienna, Vienna, Austria 3870 — A0018 Ocular surface stories after cataract surgery. Rodrigo M. Torres1, 2, P. G. Lódolo1, 2. 1Ophthalmology, Centro de Ojos Dr Lodolo, Colonia Avellaneda, Argentina; 2Asociación Entrerriana de Oftalmología, Paraná, Argentina 3871 — A0019 A Structural Equation Model (SEM) Relating Eye Pain (EP) and Ocular Surface Measurements (OSMs). Richard A. Bilonick1, 2, A. Galor3. 1UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA; 3Bascom Palmer Eye Institute, University of Miami, Miami, FL 3872 — A0020 Human blinking ‘eye-on-achip’. Jeongyun Seo1, W. Y. Byun1, A. Frank1, M. Massaro-Giordano2, V. Lee2, V. Y. Bunya2, D. Huh1. 1 Bioengineering, University of Pennsylvania, Phildelphia, PA;2Scheie Eye Institute, Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA *CR 3873 — A0021 A disease model of aqueous deficient dry eye in a microengineered ocular surface tear film platform. Nicole Qiaozhi Lu, M. P. Grant, J. Elisseeff. Wilmer Eye Institute, Johns Hopkins University, Baltimroe, MD 3874 — A0022 Contralateral investigation of postoperative refractive surgery inflammation: Small-incision Lenticule Extraction vs LASIK. Marianthi Stergiou1, A. J. Kanellopoulos1, 2, G. Asimellis1, 3.1LaserVision.gr Eye Institute, Athens, Greece; 2Ophthalmology, NYU Medical School, NY, NY; 3Kentucky College of Optometry, Pikeville, KY *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 265 Tuesday Posters 3:45 pm – 5:30 pm 3857 — A0005 Identification and Characterization of Long Noncoding RNA Contributions to Mouse Corneal Development. Weiwei Chen1, 2, S. Yang1, 2, Z. Zhou1, 2, X. Zhao1, 2, D. Yan1, 2. 1State Key Laboratory of Ophthalmology, Wenzhou Medical University, Wenzhou, China; 2 School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China 3860 — A0008 A role of primary cilia in Anterior Segment Dysgenesis disorders. Carlo Iomini, G. Laura, E. Revenkova. Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 3875 – 3896 – Tuesday – Posters 3875 — A0023 First Report of Simultaneous Double-Headed Pterygiectomy with Conjunctival Autograft, Amniotic Membrane and Fibrin Glue. Jenny Ha1, J. A. Martinez1, 2, Y. Hosseini1, M. Korchak2, J. Koppinger3, 2, S. L. Cremers1. 1 Visionary Ophthalmology, Rockville, MD; 2 Ophthalmology, Medstar Georgetown University Hospital / Washington Hospital Center, Washington, DC; 3Georgetown University School of Medicine, Washington, MD 3876 — A0024 The impact of meibomian gland dysfunction on the ocular surface parameters of glaucoma patients on long-term topical hypotensive medications. Mehmet C. Mocan, E. Uzunosmanoglu, S. Kocabeyoglu, M. T. Irkec. Department of Ophthalmology, Hacettepe Univ School of Medicine, Ankara, Turkey Tuesday Posters 3:45 pm – 5:30 pm 3877 — A0025 Microfluidic system based high throughput toxicity and efficacy screening system for eyedrops in ocular surface experiments. Kyong Jin Cho2, J. Ju3, R. Lee1, D. Kim5, 4, J. Kim1.1Biomedical Science, Dankook University Graduate School, Cheonan, Korea (the Republic of); 2Ophthalmology, College of Medicine, Dankook University, Cheonan, Korea (the Republic of); 3Biomedical Engineering, College of Health Science, Korea University, Seoul, Korea (the Republic of); 4Biomedical Engineering, College of Medicine, Dankook University, Cheonan, Korea (the Republic of); 5Beckman Laser Institute Korea, Cheonan, Korea (the Republic of) 3878 — A0026 Signal detection theory examination of ocular surface sensory processing of corneal pneumatic stimuli. Varadharajan Jayakumar, T. L. Simpson. University of Waterloo, Waterloo, ON, Canada 3879 — A0027 Ocular Involvement In Sjogren’s syndrome - The Singapore Sjogren’s Syndrome Study. Rachel Lim, D. Gunasekeran, J. Kam, B. Thong, R. V. Agrawal. Tan Tock Seng Hospital, Singapore, Singapore 3880 — A0028 HLA class I genes associated with Cold Medicine related Stevens-Johnson Syndrome with Severe Ocular Complications in the Brazilian population. Tais H. Wakamatsu1, M. Ueta2, K. Tokunaga3, Y. Okada4, R. R. Loureiro1, K. A. Costa1, J. M. Sallum1, J. Milhomens1, C. Sotozono5, J. P. Gomes1, S. Kinoshita5. 1Federal University of Sao Paulo, Sao Paulo, Brazil; 2 Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 3Department of Human Genetics, University of Tokyo, Tokyo, Japan; 4Human Genetics and Disease Diversity, Tokyo Medical and Dental University, Tokyo, Japan; 5Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan 3881 — A0029 Evaluation Of Changes In Ocular Surface After Vitrectomy Surgery. Chiara Del Noce, F. Bruzzone, S. Lai, M. ROLANDO, C. E. Traverso. DINOGMI, University of Genoa Eye Clinic, Genoa, Italy 3882 — A0030 Deletion of the Vitamin D Receptor Affects Meibomian Gland of Mice. Kai Jin1, M. Kawashima1, M. Ito2, K. Sano1, K. Tsubota1. 1 Ophthalmology, Keio University, school of medicine, Tokyo, Japan; 2National Defense Medical College, Saitama, Japan 3883 — A0031 Calculating the health economic burden of microbial keratitis (MK) admission in a tertiary referral centre in the UK. Jasvir Virdee1, G. Moussa1, N. Gooch2, J. Kigozi2, C. Penaloza2, S. Rauz1. 1Academic Unit of Ophthalmology, The University of Birmingham, Birmingham, United Kingdom; 2Health Economics Unit, The University of Birmingham, Birmingham, United Kingdom 3884 — A0032 Using corneal chemical detection thresholds to select subjects for ocular surface discrimination sensory panels. Trefford L. Simpson4, 1, N. J. Keir2, W. Ngo3, 1, Y. Feng4, 1. 1 University of Waterloo, Waterloo, ON, Canada; 2 Cooper Vision, Pleasanton, CA; 3School of Optometry & Vision Science, Centre for Contact Lens Research, Waterloo, ON, Canada; 4School of Optometry & Vision Science, Waterloo, ON, Canada *CR 3885 — A0033 Ocular Surface Homeostatic Surveillance by Th17 Cells in the Closed Eye. Cameron K. Postnikoff, K. K. Nichols. Vision Sciences, University of Alabama at Birmingham, Birmingham, AL 3886 — A0034 Grading Bulbar Redness Using The Keratograph 5M. Correlations With Efron And Mcmonnies Scales. Néstor Ventura Abreu1, F. Pérez Bartolomé1, C. Sanz Pozo1, J. Martínez de la Casa1, J. Moreno-Montanes2. 1Ophthalmology, Hospital Clínico San Carlos, Madrid, Spain; 2 Ophthalmology, Clínica Universitaria de Navarra, Pamplona, Spain 3887 — A0035 Novel pterygium animal model using White New Zealand rabbit and murine fibroblasts (NIH 3T3 cell line). Julio C. Hernandez2, J. E. Valdez2, J. Zavala2, J. Valenzuela1. 1 Tecnologico de Monterrey, School of Medicine, Monterrey, Mexico; 2Ophthalmology and Visual Sciences Research Chair, Tecnologico de Monterrey School of Medicine, Monterrey, Mexico 3888 — A0036 Lax Eyelid Syndrome, Obstructive Sleep Apnea Syndrome (OSAS), and Ocular Surface Inflammation. Mackenzie Becker1, C. Kirk1, R. Narala2, S. Kumar1, W. Adams1, C. S. Bouchard1.1Ophthalmology, Loyola University Medical Center, Maywood, IL; 2Kresge, Detroit, MI 3890 — A0038 Prosthetic Replacement of the Ocular Surface Ecosystem Therapy for Sjogren’s Syndrome Patients. Billy X. Pan, G. B. Chiu, M. Heur. Ophthalmology, USC Eye Institute, Los Angeles, CA 3891 — A0039 Prevalence and risk factors of superior limbal keratoconjunctivitis in Graves’ disease. Anfal Almazrooei1, O. Hamam1, L. Dupasqiuer2, M. Berche1, E. Heron2, C. baudouin1, A. Labbé1.1Service d’Ophtalmologie, CHNO des Quinze-Vingts, Paris, France; 2Department of Internal Medicinel, CHNO des Quinze-Vingts, Paris, France 3892 — A0040 Modulating the toxic effects of benzalkonium chloride on human corneal epithelial cells in vitro. Elham Ghahari, M. Ghahari, S. Gidfar, B. Y. Milani, S. Sanjari, M. Eslani, T. S. Vajaranant, A. A. Aref, A. R. Djalilian. ROI, University of Illinois at Chicago, Chicago, IL 3893 — A0041 Corneal bioimpedance evaluation in an animal model of anterior surface inflammation. Mario Crespo-Moral1, A. Holgueras-López1, A. Guimerà2, 3, R. Villa2, 3, M. Maldonado1. 1IOBA - University of Valladolid, Valladolid, Spain; 2Institut de Microelectrònica de Barcelona IMB-CNM (CSIC), Barcelona, Spain; 3CIBER-BBN, Networking Center on Bioengineering, Biomaterials and Nanomedicine, Zaragoza, Spain*CR 3894 — A0042 Reproducibility and Outcomes of Simple Limbal Epithelial Transplantation (SLET) technique. Alexandra Abdala, A. J. Ramirez-Miranda, A. Lichtinger, A. Navas, E. O. Graue-Hernandez. Instituto de Oftalmologia Conde de Valenciana, Mexico City, Mexico *CR 3895 — A0043 Topical Interferon Alpha-2b In Giant Squamous Ocular Surface Neoplasia. Erick Hernandez-Bogantes, A. Olivo-Payne, A. Abdala, J. Serna-Ojeda, E. O. Graue-Hernandez, A. Navas, A. J. Ramirez-Miranda. Cornea and Refractive Surgery, Insituto de Oftalmologia Fundacion Conde de Valenciana, Mexico D.F, Mexico 3896 — A0044 The fate of mesenchymal stem cells after subconjunctival implantation. Juan Li, C. Zuo, S. Ou, S. Li, L. Zhang, C. Jia, Z. Liu, W. Li. Xiamen University Medical College, Eye Institute of Xiamen University, Xiamen, China 3889 — A0037 A novel murine behavioral model of ocular neuropathic pain. Romulo Albuquerque1, J. Cho1, B. Taylor2, J. Ambati1. 1 Ophthalmology, University of Kentucky, Lexington, KY; 2Physiology, University of Kentucky, Lexington, KY *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 266 Tuesday – Posters – 3897 – 3918 Exhibit/Poster Hall A0183-A0237 Tuesday, May 03, 2016 3:45 PM-5:30 PM Glaucoma 375 Glaucoma Visual Fields and Electrophysiology Moderators: Mitra Sehi and Ryo Asaoka 3897 — A0183 Antigen-antibody interactions predict the classification and progression of glaucoma. Sarah Liebezeit, S. Beck, D. Wolters, J. Teister, K. Lorenz, N. Pfeiffer, F. H. Grus. Experimental Ophthalmology, Mainz, Germany 3898 — A0184 Visual Field Characteristics of patients with Primary Angle Closure Glaucoma: Types of defects and Hemi-field comparisons. Eray Atalay1, M. Nongpiur1, 2, S. Perera1, 3, T. T. Wong1, 3, T. Aung1, 3. 1Singapore Eye Research Institute, Singapore, Singapore; 2Duke-NUS Medical School, Singapore, Singapore; 3Singapore National Eye Center, Singapore, Singapore 3899 — A0185 Depth of Visual Field Loss Using Threshold Automated Perimetry Increases with Eccentricity in Glaucoma Subjects. Robert Wanzek1, E. Lee1, T. Eden1, A. Turpin2, L. Chong2, M. Wall1.1University of Iowa, Iowa City, IA; 2 Computing and Information Systems, University of Melbourne, Melbourne, VIC, Australia 3901 — A0187 Frequency of occurrence of abnormal test points with HFA 24-2 and 10-2 in glaucoma patients. Hiroki Nomoto, C. Matsumoto, S. Okuyama, S. Hashimoto, T. Kayasawa, M. Eura, T. Numata, S. Yamao, Y. Shimomura. Department of Ophthalmology, Kinki Univ School of Medicine, Sayama, Japan 3902 — A0188 Characteristics of glaucomatous central visual field loss as measured with the 10-2 testing pattern. Denise Pensyl, M. Sullivan-Mee, M. K. Tran, G. Tsan, S. Katiyar. Albuquerque VA Medical Center, Albuquerque, NM 3903 — A0189 A modified visual field index to measure the central visual function in eyes with fixation involvement. Debananda Padhy, A. Rao. Glaucoma service, L V Prasad Eye Institute, Bhubaneswar, India 3905 — A0191 Scheie Visual Field Grading System. Prithvi Sankar, E. G. Miller-Ellis, A. Lehman, V. M. Addis, J. D. Henderer, D. Choi, L. O’Keefe, M. Ramakrishnan, V. J. Natesh, G. J. Whitehead, J. M. O’Brien. Ophthalmology, University of Pennsylvania, Philadelphia, PA 3906 — A0192 Correlation of visual field defects and exploratory visual search performance in open angle glaucoma patients using a computer digit-based task. Cassia Senger, A. Messias, J. S. Paula. Department of Ophthalmology, Ribeirão Preto Medical School University of São Paulo, Ribeirão Preto, Brazil 3907 — A0193 Longitudinal Changes in the Useful Field of View and Standard Automated Perimetry in Patients with Glaucoma. Nara L. Lopes1, 2, C. P. Gracitelli1, 2, A. Diniz-Filho1, A. Paranhos Jr.2, F. A. Medeiros1. 1Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Department of Ophthalmology, Federal University of Sao Paulo, São Paulo, Brazil *CR 3908 — A0194 Is Vision-Related Quality of Life Impaired in Patients with Preperimetric Glaucoma? Roberta A. Nascimento1, 2, C. P. Gracitelli1, 2, A. Diniz-Filho1, L. M. Zangwill1, R. N. Weinreb1, A. Paranhos Jr.2, F. A. Medeiros1. 1 Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil *CR 3909 — A0195 Integrated Visual Field and Relative Risk for Quality of Life Loss. MARCOS MUNOZ1, O. Pujol2, A. Anton-Lopez1, 2, R. Maull2, L. Pastor2, Z. Vega2, C. Mora2, S. Gudiña2, A. Morilla-Grasa1, V. Garcia1. 1Dept of Ophthalmology, Institut Catala de Retina, Barcelona, Spain; 2Parc Salut Mar, Barcelona, Spain *CR 3910 — A0196 Minimally important Differences in the NEI-VFQ 25: Data from the TVT study. Aachal Kotecha1, W. J. Feuer2, K. Barton1, S. Gedde2. 1NIHR Biomedical Research Centre, UCL Institute of Ophthalmology & Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; 2Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL *CR, f 3911 — A0197 Evaluating Silent Reading Performance with the Eye Tracking System in Patients with Glaucoma. Noriaki Murata1, 2, M. Daiki1, T. Togano1, T. Fukuchi1. 1Division of Ophthalmology and Visual Science, Graduated School of Medical and Dental Science, Niigata University, Niigata-shi, Japan; 2Department of Orthoptics and Visual Sciences, Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata-shi, Japan 3912 — A0198 Predicting Driving Performance using the Performance-Centered Portable Test (PERCEPT) in Patients with Glaucoma. Luciana A. Fernandez1, 2, A. Diniz-Filho1, C. P. Gracitelli1, 2, E. R. Boer1, P. Rosen1, A. Paranhos Jr.2, F. A. Medeiros1. 1Laboratory of Performance and Visual Function, Department of Ophthalmology, University of California San Diego, La Jolla, CA; 2 Department of Ophthalmology, Federal University of São Paulo, Sao Paulo, Brazil *CR 3913 — A0199 Illness perception and beliefs in people newly diagnosed with glaucoma and ocular hypertension. Csilla Ajtony1, T. Boodhna2, L. McDonald2, P. Turnbull3, R. R. Bourne3, 1, D. Crabb2.1Glaucoma Service, Moorfields Eye Hospital NHS Trust London, London, United Kingdom; 2Optometry and Visual Science, School of Health Science, City University London, London, United Kingdom; 3Ophthalmology, Hinchingbrooke Health Care NHS Trust, Huntingdon, United Kingdom 3914 — A0200 Preliminary Assessment of Humphrey Visual Field Automated Perimetry Reliability Indices as a Predictor of Mortality Risk. Oliver L. Yeh1, R. Singh2, A. K. Junk1, 2, K. M. Cavuoto1, T. C. Chang1, 2. 1Bascom Palmer Eye Institute, Miami, FL; 2Ophthalmology, Miami Veterans Affairs Healthcare System, Miami, FL 3915 — A0201 The Association between progression of visual field loss and body mass index in normal tension glaucoma. Kyu-Ryong Choi, A. Kim, K. Han, R. Jun. Department of Ophthalmology, Ewha Womans University, Seoul 3916 — A0202 Monitoring Visual Field Loss Progression In Open Angle Glaucoma Using Eyesuite Perimetry Software. Carmen MendezHernandez, F. Pérez Bartolomé, J. García Feijoó. Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain 3917 — A0203 Sequence effects during visual field assessment. Marco A. Miranda1, P. H. Artes2. 1 Visual Neuroscience, NIHR Biomedical Research Centre, Moorfields Eye Hospital and UCL IoO, London, United Kingdom; 2School of Health Professions, Plymouth University, Plymouth, United Kingdom 3918 — A0204 Visual field analysis tools for real world clinics. Susan R. Bryan, D. Crabb. Optometry and Visual Science, City University London, London, United Kingdom *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 267 Tuesday Posters 3:45 pm – 5:30 pm 3900 — A0186 Preperimetric glaucoma study 1: Analysis of visual field defect in preperimetric glaucoma. Naoko Aizawa1, Y. Shiga1, S. Tsuda1, K. Omodaka1, Y. Yokoyama1, T. Yasui2, K. Kato3, T. Nakazawa1. 1Ophthalmology, Tohoku University, Sendai, Japan; 2Yasui eye clinic, Rifu, Japan; 3Kato eye center, Taiwa, Japan *CR, f 3904 — A0190 Probable Central Nervous System Mediated Enhancement of Perimacular Visual Function. Shannon Leon1, W. E. Sponsel1, S. L. Groth2, N. Satsangi5, T. Maddess4, M. A. Reilly3, A. Schnegg1, R. Trevino1, C. Majcher1. 1Rosenberg School of Optometry, San Antonio, TX; 2University of North Carolina, Chapel Hill, NC; 3University of Texas San Antonio, San Antonio, TX; 4Australian National University, Canberra, ACT, Australia; 5 University of Texas Health Science Center, San Antonio, TX 3919 – 3940 – Tuesday – Posters 3919 — A0205 Detecting Glaucomatous Progression from Localized Visual Function Changes with Corrections for Multiple Comparison. Srinivas Rajaraman1, R. Singh1, S. Yousefi2, C. Bowd2, L. M. Zangwill2, R. N. Weinreb2, M. Balasubramanian1. 1Electrical and Computer Engineering, The University of Memphis, Memphis, TN; 2Shiley Eye Institute, University of California, San Diego, CA *CR, f 3920 — A0206 Reducing variability of perimetric global indices from eyes with progressive glaucoma by censoring unreliable sensitivity data. Manoj Pathak1, S. Demirel2, S. K. Gardiner2. 1Mathematics and Statistics, Murray State University, Murray, KY; 2Legacy Research Institute, Portland, OR 3921 — A0207 Behavioural evidence that retinal ganglion cells do not saturate with 15dB perimetric stimuli. Andrew J. Anderson1, A. M. McKendrick1, A. Turpin2. 1Optometry & Vision Sciences, University of Melbourne, Parkville, VIC, Australia; 2Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia Tuesday Posters 3:45 pm – 5:30 pm 3922 — A0208 Current Perimetric Procedures have Low Probability of Detecting Glaucomatous Progression in Moderate to Advanced Disease. Andrew Turpin1, A. M. McKendrick2. 1Computing and Information Systems, University of Melbourne, Melbourne, VIC, Australia; 2Optometry & Vision Science, University of Melbourne, Melbourne, VIC, Australia *CR 3923 — A0209 The detection of progression from moderate visual field damage requires a visual field test that assesses for spatial spread rather than deficit depth. Allison M. McKendrick1, W. H. Morgan2, A. Turpin3. 1Optometry & Vision Science, University of Melbourne, Parkville, VIC, Australia; 2Lions Eye Institute, University of Western Australia, Nedlands, WA, Australia; 3 Computing and Information Systems, University of Melbourne, Parkville, VIC, Australia *CR 3924 — A0210 Introducing a novel technique to investigate performance of the GOANNA visual field algorithm in human observers. Luke Chong1, 2, A. Turpin3, A. M. McKendrick1. 1 Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC, Australia; 2 School of Optometry, University of California Berkeley, Berkeley, CA; 3Department of Computing and Information Systems, The University of Melbourne, Parkville, VIC, Australia *CR 3925 — A0211 Performance of an Accelerated Threshold Visual Field Test Strategy. Gary C. Lee1, A. Heijl2, P. Sha1, T. Callan1, M. K. Durbin1, T. Severin3, S. Radhakrishnan4, 5, A. G. Iwach4, 5, B. Bengtsson2. 1Clinical and Applications Development, Carl Zeiss Meditec, Inc, Dublin, CA; 2Ophthalmology, University of Lund, Malmo, Sweden; 3East Bay Eye Center, San Ramon, CA; 4 Glaucoma Center of San Francisco, San Francisco, CA; 5Glaucoma Research and Education Group, San Francisco, CA *CR 3926 — A0212 Repeatability of SITA Standard and SITA Fast Visual Fields. Sophia Yu, G. C. Lee, M. K. Durbin, T. Callan. Clinical & Applications Development, Carl Zeiss Meditec, Inc, Dublin, CA *CR 3927 — A0213 Evaluating equivalence between the new Humphrey Field Analyzer (HFA3) and HFA II-i. Thomas Callan1, P. Sha1, J. Y. Luu1, S. Yu1, A. Chang1, T. Severin2, Y. Duh3. 1Carl Zeiss Meditec, Inc., Dublin, CA; 2East Bay Eye Center, San Ramon, CA; 3ClinReg Consulting Services, Inc., Laguna Beach, CA *CR 3928 — A0214 Reliability of the Heidelberg Edge Perimeter (HEP) glaucoma screening compared to conventional 24-2-visual field tests in glaucoma patients. Matthias M. Mauschitz1, C. K. Brinkmann2, F. G. Holz2, M. M. Breteler1, R. P. Finger2. 1German Center for Neurodegenerative Diseases, Bonn, Germany; 2Department for Ophthalmology, University of Bonn, Bonn, Germany *CR 3929 — A0215 Threshold fluctuation comparison between Oculus Smartfield Spark strategy and Humphrey Sita Fast. Rodrigo Abreu1, P. Rodriguez-Esteve1, C. Pena-Betancor2, M. Gonzalez-Hernandez2, M. Gonzalez-de la Rosa3. 1Ophthalmology, University Hospital of La Candelaria, El Sauzal, Spain; 2Ophthalmology, University Hospital of the Canary Island, La Laguna, Spain; 3University of La Laguna, La Laguna, Spain *CR 3930 — A0216 Comparison of visual field artifact from two visual field analyzers. Tamara L. Berezina1, A. S. Khouri1, C. Horan2, R. D. Fechtner1. 1Institute of Ophthalmology and Visual Science, Rutgers - New Jersey Medical School, Newark, NJ; 2University Hospital, Newark, NJ *CR 3931 — A0217 An internal review comparing the reliability indices of Humphrey visual fields at our various facilities. Daniel Malach, J. Tannir, B. A. Hughes, R. Swendris, A. Shukairy, C. Kim. Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 3932 — A0218 Comparison of Compass and Humphrey perimeters in detecting glaucomatous defects. Paolo Fogagnolo1, A. Modarelli1, M. Digiuni1, G. Montesano1, F. Oddone2, N. Orzalesi1, L. Rossetti1.1Dipartimento Testa-Collo, San Paolo Hospital, University of Milan, Italy, Milan, Italy; 2 GB Bietti Foundation, Rome, Italy *CR, f 3933 — A0219 Comparison of two strategies to calculate perimetric sensitivity with the Compass perimeter. Luca Rossetti, P. Fogagnolo, M. Digiuni, A. Modarelli, G. Montesano. Dipartimento Testa-Collo, San Paolo Hospital, University of Milan, Milano, Italy *CR 3934 — A0220 Normal threshold size of stimuli in children using a game-based visual field test. Yanfang Wang1, 2, Z. Ali2, 1, T. Robinson3, S. Shakir2, 1, T. Fernandes1, S. Biswas2, 1, C. Fenerty2, 1, D. Henson1, 2, T. Aslam2, 1. 1University of Manchester, Manchester, United Kingdom; 2Manchester Royal Eye Hospital, Manchester, United Kingdom; 3None, Manchester, United Kingdom 3935 — A0221 OPTIC study: Feasibility and reliability of perimetry in children with glaucoma. Dipesh E. Patel1, 2, B. C. Walters4, 5, I. Russell-Eggitt1, 5, J. S. Rahi1, 3, P. Cumberland1, 5. 1 Life Course Epidemiology and Biostatistics Section, UCL Institute of Child Health, London, United Kingdom; 2Moorfields Eye Hospital, London, United Kingdom; 3UCL Institute of Ophthalmology, London, United Kingdom; 4Great Ormond Street Hospital, London, United Kingdom; 5 Ulverscroft Vision Research Group, London, United Kingdom 3936 — A0222 Clinical validation of a tablet perimeter. Algis J. Vingrys1, J. K. Healey1, S. Liew1, V. Saharinen1, M. Tran1, W. Wu1, Y. X. Kong2. 1 Optometry & Vision Sciences, University of Melbourne, Melbourne, VIC, Australia; 2Centre of Eye Research Australia, Melbourne, VIC, Australia *CR 3937 — A0223 Development of a LED-Based Visual Field System: Comparison with Standard Automated Perimetry. Jaheon Kang. Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of) 3938 — A0224 Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Perimetry. Jonathan Denniss, A. Astle. School of Psychology, University of Nottingham, Nottingham, United Kingdom 3939 — A0225 Effectiveness of tracking function of imo®, a head-mount type perimeter. Takuya Numata1, C. Matsumoto1, S. Yamao1, H. Nomoto1, F. Tanabe1, S. Hashimoto1, S. Okuyama1, Y. Shimomura1, M. Aihara2, S. Kimura3, K. Yamanaka3. 1Kinki Univ Faculty of Medicine, Osaka-Sayama City, Japan; 2The University of Tokyo, Bunkyou-ku, Japan; 3CREWT Medical Systems, Tokyo, Japan *CR 3940 — A0226 The nGoggle: A Portable Brain-Based Method for Assessment of Visual Function Deficits in Glaucoma. Felipe A. Medeiros1, J. K. Zao1, Y. Wang1, M. Nakanishi1, Y. Lin1, A. Diniz-Filho1, T. Jung2. 1Laboratory of Performance and Visual Function, University of California San Diego, La Jolla, CA; 2Swartz Center for Computational Neuroscience, University of California San Diego, San Diego, CA *CR The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 268 Tuesday – Posters – 3941 – 3959 3941 — A0227 Temporal Contrast Sensitivities are Locally Reduced around 4Hz for L-coneand around 10Hz for M-cone isolating stimuli in Glaucoma Patients. Cord R. Huchzermeyer, S. Haubner, R. Laemmer, C. Y. Mardin, J. J. Kremers. Department of Ophthalmology, FriedrichAlexander-University Erlangen-Nürnberg, Erlangen, Germany 3942 — A0228 Shape discrimination in glaucoma. Graeme J. Kennedy, G. Loffler. Department of Life Sciences, Glasgow Caledonian University, Glasgow, United Kingdom 3943 — A0229 Evaluation of pattern ERG responses using various electrodes. Anna Shengelia1, P. H. Derr2, C. Tello1. 12Manhattan Eye, Ear and Throat Hospital, Hofstra North ShoreLIJ School of Medicine, Hempstead, New York, New York, NY; 2Diopsys, East Windzor, NJ *CR 3944 — A0230 Comparison of pattern ERG to structural and functional change in subjects with suspected glaucoma. Annahita Amireskandari, D. Mantopoulos, F. M. Kapetansky, M. A. Slabaugh. Ophthalmology, Ohio State University, Columbus, OH 3945 — A0231 Repeated-Patteren Electroretinography, a new procedure for electrophysiological diagnosis of glaucoma that may improve Patteren Electroretinography specificity. Nicola Cardascia1, A. Maviglio2, D. Sisto1, P. Ferreri1, G. Alessio1. 1Ophthalmology, Policlinico Bari Univ di Bari A Moro, Rutigliano, Italy; 2Ophthalmology, ASL Brindisi, Mesagne, Italy 3947 — A0233 Electrophysiological function of intrinsically photosensitive retinal ganglion cells severely impaired in glaucoma patients. Manami Kuze1, M. Ayaki2, K. Tsubota2, M. Kondo1, T. Morita3.1Ophthalmology, Mie University Graduate School of Medicine, Matsusaka, Japan; 2Department of Ophthalmology, Keio University School of Medicine, Shinjyuku, Japan; 3International College of Arts and Sciences Department of Environmental Science, Fukuoka Women’s University, Fukuoka, Japan 3948 — A0234 Next generation PERG system and method for human studies. Pedro F. Monsalve1, G. Triolo1, 3, J. Toft-NIelsen4, R. Delgado4, E. Miskiel4, J. Bohorquez2, O. Ozcan2, W. J. Feuer1, V. Porciatti1. 1Ophthalmology, Bascom Palmer Eye institute, Miami, FL; 2Biomedical Engineering, University of Miami, MIami, FL; 3 Ophthalmology, University Scientific Institute San Raffaele, Milan, Italy; 4Intelligent Hearing System Corp., Miami, FL *CR 3950 — A0236 RETeval in Patients with Glaucoma and/or Diabetes. Victor Chen1, D. B. Kim3, S. E. Brodie4, G. Wu2. 1UC San Diego, San Jose, CA; 2Ophthalmology, UC San Francisco School of Medicine, San Francisco, CA; 3UC Berkeley, Berkeley, CA; 4Ophthalmolgy, Icahn School of Medicine at Mt. Sinai, New York, NY 3951 — A0237 Visual and Auditory Induced Event-Related Brain Dynamics in Glaucoma. Masaki Nakanishi1, 2, A. Diniz-Filho1, E. R. Boer1, A. Elhosseiny1, T. Jung2, F. A. Medeiros1. 1Laboratory of Performance and Visual Function, University of California San Diego, La Jolla, CA; 2Swartz Center for Computational Neuroscience, University of California San Diego, La Jolla, CA *CR Exhibit/Poster Hall B0089-B0106 Tuesday, May 03, 2016 3:45 PM-5:30 PM Visual Psychophysics/Physiological Optics 376 Accommodation Moderator: Mary Ann Croft 3952 — B0089 Does dynamic accommodation respond to the shape of the blurred retinal image without changes in physical vergence? Ivan Marin-Franch1, 2, P. Bernal-Molina1, 2, A. J. Del Águila-Carrasco1, 2, P. B. Kruger3, J. EsteveTaboada1, R. Montés-Micó1, N. Lopez-Gil2. 1 Departamento de Óptica y Optometría y Ciencias de la Visión, Universitat de València, Burjassot, Spain; 2Ciencias de la Visión research group, Facultad de Óptica y Optometría, Universidad de Murcia, Murcia, Spain; 3College of Optometry, State University of New York, New York, NY 3953 — B0090 Determination of porcine ciliary muscle contractility to adapt innovative lens replacement materials. Thomas Stahnke1, T. Noack2, R. Patejdl2, S. Hartleib2, A. Wree3, O. Stachs1, N. Grabow4, R. Guthoff4. 1Department of Ophthalmology, Rostock University Medical Center, Rostock, Germany; 2Department of Physiology, Rostock University Medical Center, Rostock, Germany; 3Institute of Anatomy, Rostock University Medical Center, Rostock, Germany; 4 Institute of Biomedical Engineering, Rostock University Medical Center, Rostock, Germany 3954 — B0091 Effect of phenylephrine on static and dynamic accommodation. Paula BernalMolina1, 2, A. J. Del Águila-Carrasco1, 2, N. LopezGil2, F. Lara2, P. B. Kruger3, R. Riquelme-Nicolás2, R. Montés-Micó1, J. Esteve-Taboada1, I. MarinFranch1, 2. 1Universidad de Valencia, Burjassot, Spain; 2Universidad de Murcia, Murcia, Spain; 3 State University of New York, New York, NY 3955 — B0092 Defining the Nyquist Sampling limit for Dynamic Accommodation. Vivek Labhishetty, W. R. Bobier, V. Lakshminarayanan. School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada 3956 — B0093 Accommodative Accuracy and Stability In Passive and Active Viewing Tasks in Children with Uncorrected Hyperopia. Tawna L. Roberts1, 2, J. S. Benoit2, 3, R. E. Manny2, S. B. Stevenson2, H. A. Anderson2. 1Ophthalmology, Akron Children’s Hospital, Akron, OH; 2University of Houston College of Optometry, Houston, TX; 3 University of Houston TIMES Institute, Houston, TX 3957 — B0094 On the usefulness of Badal optometer to stimulate accommodation. Mikel Aldaba1, 2, J. Pujol1, 2, C. Otero1, 2. 1Centre for Sensors, Instruments and Systems Development, Universitat Politècnica de Catalunya, Terrassa, Spain; 2Davalor Research Center, Universitat Politècnica de Catalunya, Terrassa, Spain *CR 3958 — B0095 Retinal blood vessels may be used to detect the sign of defocus. Norberto Lopez-Gil1, M. T. Jaskulski1, F. Vargas-Martin1, P. B. Kruger2. 1Physics, Universidad de Murcia, Murcia, Spain; 2State University of New York (SUNY), New York, NY 3959 — B0096 OCT Biometry of the Crystalline Lens during Dynamic Accommodation. Siobhan Williams1, 2, M. Ruggeri1, 2, F. Manns1, 2, G. Gregori3, Y. Chang1, 2, S. H. Yoo3, J. A. Parel1, 4. 1Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, FL; 3 Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 4Vision Cooperative Research Centre, Sydney, NSW, Australia *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 269 Tuesday Posters 3:45 pm – 5:30 pm 3946 — A0232 Steady-State Pattern Electroretinogram and Transient Visual Evoked Potentials Analysis in Glaucomatous and Healthy Eyes. Michael Waisbourd, A. Resende, A. Dilru, S. Puri, M. Moster, L. A. Hark, L. Katz, A. Mantravadi. Ophthalmology, Wills Eye Hospital, Philadelphia, PA *CR, f 3949 — A0235 Repeatability of Steady-State Pattern Electroretinogram and Full-Field Electroretinogram using a novel office-based testing platform in normal subjects. Arthur Resende, M. Waisbourd, L. A. Hark, A. Mantravadi, L. Katz. Ophthalmology, Wills Eye Hospital, Philadelphia, PA *CR, f 3960 – 3977 – Tuesday – Posters 3960 — B0097 Dynamic Interaction of the Ciliary Muscle and Crystalline Lens during Accommodation evaluated with SD-OCT. Marco Ruggeri1, C. De Freitas1, S. Williams1, 2, V. M. Hernandez1, 2, F. Cabot1, 3, K. Alawa1, Y. Chang1, 2, G. Gregori4, S. H. Yoo1, 3, J. A. Parel1, 5, F. Manns1, 2. 1 Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami, College of Engineering, Coral Gables, FL; 3Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 4Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 5Brien Holden Vision Institute and Vision Cooperative Research Centre, Sydney, NSW, Australia *CR 3961 — B0098 Axial length and dynamic disaccommodation changes accompanying prolonged near work. Yilei Shao, J. Ye, Y. Yuan, S. huang, M. Shen, F. Lu. School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China Tuesday Posters 3:45 pm – 5:30 pm 3962 — B0099 Near work-induced transient myopia after short near work duration among Malay adults. Azmir Ahmad1, 2, A. Chen2. 1 Optometry, Faculty of Health Sciences, Universiti Teknologi MARA (UiTM), Puncak Alam, Malaysia; 2 iROViS, Health and Wellbeing CORE, Research Mangement Center (RMC), Universiti Teknologi MARA (UiTM), Shah Alam, 40460, Malaysia 3963 — B0100 Static and Dynamic Accommodation and Pupil Responses of Early Presbyopes Viewing through Monovision Corrections. Meznah S. Almutairi, B. Altoaimi, A. Bradley. Optometry, Indiana University, Bloomington, IN 3964 — B0101 Dynamic Changes of the Internal Structure of the Lens with Accommodation. Yu-Cherng Chang1, 2, M. Ruggeri1, 2, K. George3, S. H. Yoo3, J. A. Parel1, 4, F. Manns1, 2. 1Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 2Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL; 3Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL; 4Vision Cooperative Research Centre, Sydney, NSW, Australia *CR 3965 — B0102 Heritability of ocular dimensions and geometry in humans. Antonio Benito1, J. Tabernero1, L. Hervella1, J. F. SánchezRomera2, J. R. Ordoñana2, M. Ruiz-Sánchez3, J. M. Marín3, P. Artal1.1Laboratorio de Óptica, Universidad de Murcia, Murcia, Spain; 2Murcia Twin Registry, Area of Psychobiology, Murcia, Spain; 3Hospital Universitario Arrixaca, Murcia, Spain 3966 — B0103 3D Cinema And Visual Discomfort. Christine Tanguy1, C. Hugny Larroque1, S. Ferragut2, M. Lamard2, B. Cochener1, 2. 1Ophtalmologie, Chu Morvan, Brest, France; 2LATIM, Brest, France 3967 — B0104 Study of accommodative function examination to assess visual fatigue induced by watching 3D video. Li Zhang, L. Xu, J. Li, S. Zhao. Ophthalmology, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing, China 3968 — B0105 Accommodation response to step changes in disparity vergence when viewing stereoscopic displays. Ana Fernandez, D. Seidel, L. E. Sweeney, L. Gray. Vision Sciences, Glasgow Caledonian University, Glasgow, United Kingdom 3969 — B0106 Changes in visual function, ocular biometry and dry eye in naïve diabetic patients after euglycemic control. Karim Mohamed-Noriega1, G. Gonzalez-Saldivar1, J. González-González2, R. Rodriguez-Gutiérrez2, J. Mohamed-Noriega1, H. Cavazos1, G. Villarreal Méndez1, J. H. Gonzalez1, E. Cuervo-Lozano1, J. Mohamed-Hamsho1. 1Dpto. Oftalmologia, Hospital Universitario, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico; 2 Endocrinology, Hospital Universitario “Dr. José E. Gonzalez”, Universidad Autónoma de Nuevo León, Monterrey, Mexico Exhibit/Poster Hall B0137-B0152 Tuesday, May 03, 2016 3:45 PM-5:30 PM Clinical/Epidemiologic Research 377 Clinical Aspects of Refractive Error Moderator: Robert Wojciechowski 3970 — B0137 Effectiveness of Low-Cost Glasses Distribution in the USA, Guatemala, Ghana, Cambodia, Peru and the Dominican Republic. Laetitia Truong1, B. Briggs3, L. Weiner1, N. Mamdani2, O. Kosoko-Lasaki1, 3. 1Creighton University School of Medicine, Omaha, NE; 2 First Sight,LLC, Omaha, NE; 3Health Sciences Multicultural and Community Affairs, Creighton University, Omaha, NE 3971 — B0138 Disparities in eyeglass insurance coverage in Canada. Gordon Ngo1, G. E. Trope3, Y. M. Buys2, Y. Jin2. 1Medicine, University of Western Ontario, London, ON, Canada; 2Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; 3Cell Biology, University of Toronto, Toronto, ON, Canada 3972 — B0139 Spectacle use in a rural population in the state of Telangana in South India. Srinivas Marmamula, R. Challa, E. K, R. C. Khanna. GPR ICARE, L V Prasad Eye Institute, Hyderabad, India 3973 — B0140 Spectacle Coverage in Older Adults from Parintins: The Brazilian Amazon Region Eye Survey (BARES). Galton C. Vasconcelos6, 1, N. N. Cavascan1, A. Berezovsky1, C. C. Cunha1, S. Munoz2, J. M. Furtado3, J. M. Cohen4, M. J. Cohen5, R. Belfort1, S. R. Salomao1. 1Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São, São Paulo, Brazil; 2 Departamento de Salud Publica, Universidad de La Frontera., Temuco, Chile; 3Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Ribeirão Preto USP, Ribeirão Preto, Brazil; 4 Divisão de Oftalmologia, Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus, Brazil; 5Instituto de Olhos de Manaus, Manaus, Brazil; 6Oftalmologia e Otorrinolaringologia, Universidade Federal de Minas Gerais UFMG, Belo Horizonte, Brazil 3974 — B0141 Prevalence of refractive errors in a large German cohort of children and adolescents. Heike Lange1, 2, M. Vogel2, A. Ohlendorf3, S. Wahl3, P. M. Wiedemann1, W. Kiess2, 4, F. G. Rauscher1.1Department of Ophthalmology, University Hospital Leipzig, Leipzig, Germany; 2 Leipzig Research Centre for Civilization Diseases -LIFE, Faculty of Medicine, University of Leipzig, Leipzig, Germany; 3Institute for Ophthalmic Research, University Tübingen, Tübingen, Germany; 4Centre of Paediatric Research, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany *CR 3975 — B0142 Longitudinal changes in refractive error in Korean children. Young Shin Kim, S. Park. Ophthalmology, Soonchunhyang University Seoul Hospital, Seoul, Korea (the Republic of) 3976 — B0143 National Eye Survey of Trinidad and Tobago: the prevalence and risk factors for refractive error. Shivaa S. Ramsewak5, N. Verlander4, F. Deomansingh3, A. Fraser3, V. Maharaj3, S. Sharma3, D. Singh2, R. R. Bourne1, T. Braithwaite1. 1Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, United Kingdom; 2 Caribbean Eye Institute, Valsayn, Trinidad and Tobago; 3Department of Optometry, University of the West Indies, Saint Augustine, Trinidad and Tobago; 4Public Health England, London, United Kingdom; 5London School of Hygiene and Tropical Medicine, London, United Kingdom 3977 — B0144 Familial Concordance of Refractive Errors in Korean Children: The Korea National Health and Nutrition Examination Survey 2008-2012. Dong Hui Lim1, 2, T. Chung1, J. Han3, S. Nam1, H. Yim2. 1 Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of); 2Preventive Medicine, Graduate School, College of Medicine, The Catholic University of Korea, Seoul, Korea (the Republic of); 3Ophthalmology, Myongji Hospital, Seoul, Korea (the Republic of) The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 270 Tuesday – Posters – 3978 – 3996 3978 — B0145 Comparison of refractive error measurements in adults obtained by autorefraction and subjective refraction. Prateek Gajwani, L. I. Mudie, D. Zhao, C. Ogega, E. Johnson, D. S. Friedman. Wilmer Eye Institute, Baltimore, MD 3979 — B0146 Prevalence of myopia and astigmatism in adults in Germany. Arne Ohlendorf1, 2, H. Lange3, 4, M. Vogel4, S. Wahl1, 2, P. M. Wiedemann3, W. Kiess4, 5, F. G. Rauscher3. 1 Carl Zeiss Vision International GmbH, Technology & Innovation, Aalen, Germany; 2University Tuebingen, Institute for Ophthalmic Research, Tuebingen, Germany; 3University Hospital Leipzig, Department of Ophthalmology, Leipzig, Germany; 4 Faculty of Medicine, Leipzig Research Centre for Civilization Diseases - LIFE, Leipzig, Germany; 5 Hospital for Children and Adolescents, Centre of Paediatric Research, Leipzig, Germany *CR 3980 — B0147 Posterior corneal shape following gain or loss of keratometric astigmatism. Joseph M. Miller1, 2, M. W. Belin1, E. M. Harvey1, 2. 1Ophthalmology and Vision Science, University of Arizona, Tucson, AZ; 2College of Public Health, University of Arizona, Tucson, AZ *CR 3982 — B0149 Longitudinal changes of Astigmatism in School-aged Children. Lili Wang1, X. Guo1, X. Ding1, M. He1, 2. 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; 2 Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia 3983 — B0150 Distribution of mean refractive error for London 2012 competitors and support teams. Manbir Nagra1, C. Wilson2, S. Ceccon1, W. D. Thomson1, P. J. D’Ath1. 1Division of Optometry and Visual Science, City University London, London, United Kingdom; 2Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom Exhibit/Poster Hall B0164-B0174 Tuesday, May 03, 2016 3:45 PM-5:30 PM Nanotechnology and Regenerative Medicine Group 378 Ocular pharmacological and biological applications of nanotechnology Moderators: Christine F. Wildsoet and T homas A. Fuchsluger 3986 — B0164 Controlled vancomycin release from biodegradable nanoparticles. Emily Dosmar1, J. J. Kang-Mieler1, W. F. Mieler2. 1 Biomedical Engineering, Illinois Institute of Technology, Chicago, IL;2Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 3987 — B0165 Efficacy and dose dependent response of intravenous dendrimertriamcinolone acetonide conjugates in CNV suppression. Siva Pramodh Kambhampati1, 2, I. A. Bhutto1, K. Ho1, G. A. Lutty1, 2, K. Rangaramanujam1, 2. 1Wilmer Eye Institute -Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD; 2Center for Nanomedicine, Johns Hopkins School of Medicine, Baltimore, MD 3988 — B0166 Novel polymer-based mucoadhesive and degradable nanoparticles for delivery of ophthalmic drugs. Nicole Mangiacotte1, G. Prosperi-Porta2, M. Jamard1, L. Liu1, H. Sheardown1. 1Chemical Engineering, McMaster University, Hamilton, ON, Canada; 2 Cumming School of Medicine, University of Calgary, Calgary, AB, Canada 3989 — B0167 Study on the effect of size of nanocarriers on trans-scleral transport. Rini R. Joseph2, T. T. Wong1, 3, S. Venkatraman2. 1Singapore National Eye Centre, Singapore, Singapore, Singapore; 2Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore; 3Ocular Drug Delivery Group, Singapore Eye Research Institute, Singapore, Singapore 3990 — B0168 Mucoadhesive nanoparticle eye drop platform: tracking of ocular retention and treatment of experimental dry eye. Shengyan Liu1, M. Dozois1, C. Chang1, D. Hileeto2, H. Liang3, 4, M. Reyad3, 4, S. R. Boyd3, 4, L. W. Jones2, F. Gu1. 1 Chemical Engineering, University of Waterloo, Waterloo, ON, Canada; 2Centre for Contact Lens Research, University of Waterloo, Waterloo, ON, Canada; 3Keenan Research Centre for BIomedical Science, St. Michael’s Hospital, Toronto, ON, Canada; 4Department of Opthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada *CR 3991 — B0169 Evaluation of Antioxidant Catalase in Sodium Hyaluronate-albuminchitosan microparticles for inhibition of LPS-induced ROS in Ex-vivo models of choroidal neovascularization. Rodney C. Siwale. Pharmaceutical Sciences, Western New England University College of Pharmacy, Springfield, MA 3992 — B0170 Release of Avastin from laser-stimulated nanocarriers. Lauren M. Wright1, A. Catala2, K. L. Nash2, R. D. Glickman1. 1 Ophthalmology, Univ. of Texas Hlth. Sci. Ctr., San Antonio, TX; 2Physics & Astronomy, Univ. Texas San Antonio, San Antonio, TX 3993 — B0171 Nanoparticle Mediated Efficient Treatment Strategy for Photocoagulation of Retinal and Choroidal Neovascularization of Diabetic Retinopathy. Rupesh Singh, M. Balasubramanian. Electrical and Computer Engineering, University of Memphis, Memphis, TN *CR 3994 — B0172 Targeted Delivery of YSA-Functionalized PLGA Nanoparticles to Endothelial Cells. Arun K. Upadhyay1, T. Carpenter2, E. Grayck2, U. B. Kompella1. 1 Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO; 2Pediatric Critical Care Medicine, University of Colorado Denver, Aurora, CO 3995 — B0173 Magnetic Hyperthermia Treatment in Y-79 Retinoblastoma and ARPE19 RPE Cells: Concentration Dependent Effect of Iron Oxide Nanoparticle. Naziha Slimani1, M. D. Pawar1, Z. Gursel Ozkurt1, R. Tucker2, P. Vaishnava2, C. G. Besirli1, H. Demirci1. 1kellogg eye center, Canton, MI; 2kettering university, Flint, MI 3996 — B0174 Long Term Culture of Human Lens Tissue for Screening Drugs with the Potential to Prevent PCO. Jacquelyn V. Gerhart1, M. Greenbaum2, R. Getts1, M. George-Weinstein3. 1 Genisphere, LLC, Hatfield, PA; 2Lankenau Medical Center, Wynnewood, PA; 3Cooper Medical School of Rowan University, Camden, NJ *CR 3984 — B0151 Refractive Error & Academic Achievement. Lesley Doyle, S. McCullough, K. Saunders. School of Biomedical Sciences, Ulster University, Coleraine, United Kingdom f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 271 Tuesday Posters 3:45 pm – 5:30 pm 3981 — B0148 Total, corneal and ocular residual astigmatism: Distribution in a German population and age-dependency - The Gutenberg Health Study. Alexander K. Schuster1, N. Pfeiffer1, A. Schulz2, R. Hoehn1, 3, K. A. Ponto1, 4, M. Blettner5, P. S. Wild2, 4, A. Mirshahi1, 6. 1University Medical Center Mainz, Department of Ophthalmology, Mainz, Germany; 2Preventive Cardiology and Preventive Medicine / Center for Cardiology, University Medical Center Mainz, Mainz, Germany; 3 Department of Ophthalmology, Inselspital, Bern, Switzerland; 4Center for Thrombosis and Hemostasis (CTH), University Medical Center, Mainz, Germany; 5Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany; 6 Dardenne Eye Clinics, Bonn, Germany 3985 — B0152 Prevalence of refractive errors and self-reported near-work, indoor and outdoor activities in Norwegian adolescents. Jon V. B. Gjelle, L. A. Hagen, S. Arnegard, S. J. Gilson, R. C. Baraas. Optometry and Visual Science, University College of Southeast Norway, Kongsberg, Norway 3996 – 4016 – Tuesday – Posters Exhibit/Poster Hall B0175-B0219 Tuesday, May 03, 2016 3:45 PM-5:30 PM Physiology/Pharmacology / Eye Movements/ Strabismus/Amblyopia/Neuro-Ophthalmology / Low Vision / Multidisciplinary Ophthalmic Imaging / Retinal Cell Biology / Retina / Visual Neuroscience 379 Drug Delivery Moderators: Vatinee Y. Bunya and Antonino Asero Tuesday Posters 3:45 pm – 5:30 pm 3997 — B0175 SHP2 (PTPN11) over-expression by AAV gene delivery impairs neuronal cell growth in SH-SY5Y cells and induces neurodegeneration of SD rat retinal ganglion cells. Nitin Chitranshi1, V. Gupta1, R. Vanderwall1, Y. Dheer1, S. L. Graham1, 2. 1Macquarie University, Sydney, NSW, Australia; 2University of Sydney, Save Sight Institute, Sydney, NSW, Australia 3998 — B0176 Effect of Conjunctival Ring with Dexamethasone Sodium Phosphate on Rabbit VEGF-induced Blood-Retinal Barrier Breakdown. Hiroaki Takahashi1, W. Asayama1, H. Obata2, T. Matsunaga2, A. Kanda3, 4, K. Noda3, 4, S. Ishida3, 4. 1Research & Development Division, Senju Pharmaceutical Co., Ltd., Kobe, Japan; 2Research & Development Division, SEED Co., Ltd., Saitama, Japan; 3Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan; 4Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan *CR 3999 — B0177 Fabrication and characterisation of implants for intraocular delivery of triamcinolone acetonide. Kathryn McAvoy, D. Jones, R. Thakur. Pharmacy, Queens University Belfast, Belfast, United Kingdom 4000 — B0178 Eye Drop Adherence Following Retina Surgery. Daniel Glasser1, S. Charoenthongtrakul1, H. Wafapoor1, R. L. Avery2, A. M. Eaton1. 1Research, Retina Health Center, Fort Myers, FL; 2California Retina Consultants, Santa Barbara, CA *CR 4001 — B0179 Morphological and electrophysiological study of the effects of intravitreal mycophenolic acid in a model of experimental chronic uveitis in rabbits. Andre M. Liber1, G. L. Ioshimoto1, T. Z. Igami1, A. SilvaCunha2, B. V. Nagy1, M. F. Costa1, F. M. Damico1, D. F. Ventura1. 1Ophthalmology, Universidade de Sao Paulo, Sao Paulo, Brazil; 2Universidade Federal de Minas Gerais, Belo Horizonte, Brazil 4002 — B0180 Pharmacokinetics Including Ocular Distribution Characteristics of Suprachoroidally Administered CLS011A in Rabbits Could be Beneficial for a Wet AMD Therapeutic Candidate. Jennifer Kissner1, S. R. Patel1, J. J. Prusakiewicz2, D. Alton2, G. Bikzhanova2, L. Geisler2, B. Burke1, G. Noronha1. 1 Clearside Biomedical, Inc, Alpharetta, GA; 2 Covance Laboratories, Inc, Madison, WI *CR 4003 — B0181 Factors affecting protein aggregation for bevacizumab. Alexander T. Nguyen, L. T. Tainsh, P. Coady, M. Ghiassi, L. J. Rizzolo, R. A. Adelman. Ophthalmology and Visual Sciences, Yale School of Medicine, New Haven, CT 4004 — B0182 Lens Capsule Biodegradable Lipid Implant for Sustained-Release Anti-VEGF Therapy of Neovascular AMD. Sarah Molokhia1, R. M. Burr1, M. Flood2, M. Vallrath3, G. Winter3, B. K. Ambati2, 1. 1Ophthalmology, iVeena, Salt Lake City, UT; 2Moran Eye Center, Salt Lake City, UT; 3Ludwig-Maximilians-Universität München, Munich, Germany *CR 4005 — B0183 Novel modeling for the Enhancement of Decision-Making Worthiness of Ocular Pharmacokinetic Study Results. Muhammad Abdulrazik. East Jerusalem Biomedical Institute, East Jerusalem 4006 — B0184 Effect of a latanoprosteluting contact lens on IOP in glaucomatous monkeys. J. B. Serle2, J. B. Ciolino1, 3, A. Ross1, 3, R. Tulsan1, 3, R. Wang2, D. Kohane3, Janet B. Serle2. 1Ophthalmology, Massachusetts eye and ear infirmary, Boston, MA; 2Ophthalmology. Icahn School of Medicine at Mount Sinai, New York, NY; 3 Anaesthesia, Boston Children’s Hospital, Boston, MA *CR 4007 — B0185 The Preclinical Safety, Toxicity and Pharmacokinetics (Pk) of Targeted Episcleral Delivery of Topotecan (TPT), Melphalan (MEL) and Its Combination with Dexamethasone (DEX).Ricardo A. De Carvalho1, 4, P. P. Ko1, 2, A. Murphree3, R. Brito1, J. Moreno1, P. N. Wahjudi1, M. C. Vargas-Dougherty1, C. Mendes4, G. C. Matsutani4, J. Manders1. 13T Ophthalmics, Irvine, CA; 2Eye Care for Animals, San Diego, CA; 3Childrens Hospital of Los Angeles, USC, Los Angeles, CA; 43T Biopolymers, Sao Paulo, Brazil *CR 4008 — B0186 An engineered porous silica particle for sustained intravitreal delivery of mycophenolic acid. Yuqin Wang2, 1, D. Warther2, K. Huffman2, S. Rios2, D. Sengmany2, W. R. Freeman2, M. Sailor3, L. Cheng2. 1Specialty of Uveitis, 2. Eye Hospital of Zhejiang Province, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; 2Department of Ophthalmology, 1. Jacob’s Retina Center at Shiley Eye Institute, University of California San Diego, San Diego, CA; 3Department of Chemistry and Biochemistry, University of California, San Diego, CA *CR 4009 — B0187 Continuous Intravitreal AntiVEGF Delivery by Encapsulated Cell Technology (ECT): Modeling of Disease Maintenance in Patients with CNV Secondary to AMD. Christian Landeros, M. Rivera, A. M. Lelis, L. Orecchio, K. Kauper. Ophthalmology, Neurotech Pharmaceuticals, Inc., Cumberland, RI *CR 4010 — B0188 Dexamethasone Degradation During In Vitro Release from an Intravitreal Implant. Brock Matter1, A. Ghaffari1, D. Bourne1, Y. Wang2, S. Choi2, U. B. Kompella1. 1 Pharmaceutical Sciences, University of Colorado, Aurora, CO; 2Center for Drug Evaluation and Research, FDA, Silver Spring, MD 4011 — B0189 Sustained-release Drug-eluting Microrods as Ocular Implants. Anthony Ng1, X. Ng1, Y. Liu2, Y. Peng1, J. S. Mehta2, T. T. Wong2, 1, S. Venkatraman1. 1School of Materials Science & Engineering, Nanyang Technological University, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore, Singapore 4012 — B0190 Cryopreservation as a Novel Method for Encapsulated Cell Therapy Packaging, Storage, and Distribution. Michael Rivera, K. Kauper, J. Duggan, C. Landeros, L. Orecchio, C. Cortellessa, A. M. Lelis. Neurotech Pharmaceuticals, Inc., Cumberland, RI *CR 4013 — B0191 A 6-Week Toxicity and Toxicokinetics Study of a Single Bilateral Intracameral Administration of ENV905 (difluprednate) Ophthalmic Implant in New Zealand White Rabbits. RiLee Robeson1, R. S. Verhoeven1, A. Garcia1, P. Miller2, J. Miller3, T. Navratil1, R. M. Schiffman1. 1Ophthalmology, Envisia Therapeutics, Morrisville, NC; 2OSOD, Madison, WI; 3Covance Laboratories, Madison, WI *CR 4014 — B0192 Evaluation of the Biocompatibility of a New Dexamethasone Implant in the Rabbit Eye (GLP study). Michael M. Burr1, 2, S. Molokhia1, 2, B. Ambati1, 2. 1iVeena, Salt Lake City, UT; 2Moran Eye Center, Salt Lake City, UT *CR 4015 — B0193 Evaluation of a sustained release formulation of bevacizumab. Sahar Awwad1, 2, A. Al-Shohani1, 2, P. T. Khaw2, S. Brocchini1, 2. 1UCL, School of Pharmacy, London, United Kingdom; 2 National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom 4016 — B0194 Sustain release of genistein from nanoparticles surface modified IOL by ester bond to prevent posterior capsular opacification in rabbit eyes. Jinlu Liu2, 1, B. Ambati1, J. Kong2.1Ophthalmology, Moran eye center, Salt Lake City, UT; 2Ophthalmology, The fourth Affiliated Hospital of China Medical University, Shenyang, China The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 272 Tuesday – Posters – 4017 – 4035 4017 — B0195 Protective Effects of Sustained Unoprostone Release Device in Rhodopsin Pro347Leu Transgenic Rabbits. Nobuhiro Nagai2, Y. Izumida2, H. Kaji3, M. Nishizawa3, A. Katsuyama2, S. Yamada2, T. Nakazawa1, M. Kondo4, H. Terasaki5, Y. Mashima6, T. Abe2. 1Ophthalmology, Tohoku University, Sendai, Japan; 2Tohoku University Graduate School of Medicine, Sendai, Japan; 3Graduate School of Engineering, Tohoku University, Sendai, Japan; 4Mie Univ Graduate School of Med, Mie, Japan; 5Nagoya Univ School of Medicine, Nagoya, Japan; 6R-Tech Ueno, Tokyo, Japan *CR 4018 — B0196 A Sustained Release Formulation of Novel Quininib-Hyaluronic Acid microneedles inhibits Angiogenesis and Retinal Vascular Permeability in vivo. Orla M. Galvin1, A. Srivastava2, O. Carroll2, R. Kulkarni3, S. Dykes3, S. Vickers3, K. Dickinson3, R. Jones3, S. Cheetham3, A. Pandit2, B. N. Kennedy1. 1The Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland; 2Centre for Research in Medical Devices, Bioscience Building, National University of Ireland Galway, Galway, Ireland; 3RenaSci Ltd, Nottingham, United Kingdom *CR 4019 — B0197 Sustained release of DE-117 via intracameral polycaprolactone glaucoma device. Jean Kim1, M. Kudisch1, S. Mudumba2, H. Asada3, E. Shibuya3, R. Bhisitkul1, T. Desai1. 1University of California, San Francisco, San Francisco, CA; 2Santen, Inc., Emeryville, CA; 3Santen Pharmaceutical Co., Nara, Japan *CR 4021 — B0199 Treatment of Chronic Allergic Conjunctivitis with Sustained Release Dexamethasone Using a Modified Conjunctival Allergen Challenge (Ora-CAC®) Model. Deepa Mulani1, E. B. McLaurin2, C. Repke3, M. Sato4, P. J. Gomes5, E. Ankerud1, M. Bassett6, C. D. Blizzard6, A. Driscoll6, A. Sawhney6. 1Clinical, Ocular Therapeutix Inc, Bedford, MA; 2Total Eye Care, Memphis, TN; 3Philadelphia Eye Associates, Philadelphia, PA; 4East West Eye Institute, Los Angeles, CA; 5ORA, Andover, MA; 6Ocular Therapeutix Inc, Bedford, MA *CR, f 4022 — B0200 Exosomes released from ethanol-damaged RPE cells produce damage in neighboring cells. Francisco J. Romero1, S. Atienzar-Aroca1, G. Serrano2, N. Martinez1, L. Vidal-Gil1, J. BArcia1, J. Sancho-Pelluz1. 1School of Medicine, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain; 2Complejo Hospitalario de Albacete, Albacete, Spain 4024 — B0202 Spectral time sharing to simultaneously measure rhodopsin absorbance and retinol fluorescence while mitigating light scatter in living frog retina suspensions. Gabriel Gonzalez-Fernandez1, R. J. DeSa2. 1Ophthalmology, University of Mississippi Medical Center, Jackson, MS; 2Research & Development, Olis, Bogart, GA *CR 4025 — B0203 rAAV8 biodistribution and shedding after subretinal injection in nonhuman primates. Immanuel Philipp Seitz1, 2, M. Fischer1, 2, S. Michalakis3, B. Wilhelm4, N. Kahle4, E. Zrenner2, M. Ueffing2, K. Bartz-Schmidt1, 2, M. Biel3, B. Wissinger2, T. Peters2. 1University Eye Hospital Tübingen, Tübingen, Germany; 2Institute for Ophthalmic Research, University of Tübingen, Centre for Ophthalmology, Tübingen, Germany; 3 Center for Integrated Protein Science Munich (CIPSM), Departement of Pharmacology, LudwigMaximilians-Universität München, Munich, Germany; 4STZ eyetrial, University of Tübingen, Centre for Ophthalmology, Tübingen, Germany 4026 — B0204 Ocular and systemic safety of a HIV-1-derived lentiviral vector after subretinal injection in Macaca fascicularis eyes. Corinne Kostic1, A. Matet1, F. Mavilio2, S. Martin2, A. Bemelmans3, F. F. Behar-Cohen1, Y. Arsenijevic1. 1 Dpt Ophthalmology, Jules-Gonin Eye Hosp, Univ Lausanne, Lausanne, Switzerland; 2Genethon, Evry, France; 3URA2210, CEA/CNRS, MirCEN, Fontenay-les-Roses, France 4027 — B0205 Evaluation of efficacy of liposomal triamcinolone acetonide as targeted anti-inflammatory treatment in a rabbit model of experimental uveitis. Chee Wai Wong1, 2, B. Czarny3, S. Ng1, 2, V. A. Barathi2, B. Metselaar4, G. Storm4, T. T. Wong1, 2. 1Ophthalmology, Singapore National Eye Centre, Singapore, Singapore; 2 Singapore Eye Research Institute, Singapore, Singapore; 3Department of Pharmacy, National University of Singapore, Singapore, Singapore; 4 MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Twente, Netherlands 4028 — B0206 Bioactivity Studies Of Biodegradable GDNF/VitE Loaded Microspheres In Organotypic Cultures Of Neonatal Rat Retina. Rocio Herrero-Vanrell1, 2, C. García-Caballero1, 2, B. Arango-González3, I. Bravo-Osuna1, 2, M. Ueffing3. 1Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Complutense University, Madrid, Spain; 2Red Temática de Investigación Cooperativa Sanitaria en Enfermedades Oculares OFTARED and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; 3Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany 4029 — B0207 Sustained Release Biodegradable Formulations for Intraocular Delivery: Extended Release of Hydrophilic APIs and Combination Products. Janet Tully, M. Yang, M. Sandahl, S. Williams, R. Schiffman. Ophthalmology, Envisia Therapeutics, Moorisville, NC *CR 4030 — B0208 Electric field-mediated targeting of drug delivery in the suprachoroidal space. Jae Hwan Jung, B. Chiang, M. R. Prausnitz. Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 4031 — B0209 A Novel Biocompatible, Membrane-Interactive Delivery System for Administration of an Ophthalmic Antiinflammatory Drug. Kevin L. Ward1, K. S. Crawford1, 2, M. Liu1, A. L. Cromwick1, S. P. Barman1. 1Integral Biosystems LLC, Bedford, MA; 2 PharmOcu, Bedford, MA *CR 4032 — B0210 Determination of the optimum delivery route for the intraglandular administration of botulinum toxin A in patients with refractory epiphora. Christina Y. Weng1, E. Houle2, K. C. Oktavec3, J. Tian4, S. L. Merbs4. 1 Ophthalmology, Baylor College of MedicineCullen Eye Institute, Houston, TX; 2Ophthalmology, University of Vermont, Burlington, VT; 3 Ophthalmology, Columbia University, New York, NY; 4Ophthalmology, Johns Hopkins University, Baltimore, MD f 4033 — B0211 Ultrahigh field MR - Imaging of a polymeric Injectable Local Drug Delivery System. Karen Falke1, T. Lindner3, S. Polei3, F. Kopp2, T. Eickner2, T. Stahnke2, A. Jünemann1, O. Stachs1, R. Guthoff2. 1Eye Deparment, University of Rostock, Rostock, Germany; 2Institute for Biomedical Engineering, University of Rostock, Rostock, Germany; 3Core Facility Multimodal Small Animal Imaging, Rudolf Zenker Institut for Institute for Experimental Surgery, University Medicine Rostock, Rostock, Germany 4034 — B0212 Targeted delivery of sFLT-MO using cyclic RGD peptide suppresses laser CNV. Hironori Uehara, S. K. Muddana, X. Zhang, A. Bohner, B. Ambati. Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT 4035 — B0213 Calixarene-based nanoformulation for ocular delivery of curcumin: in vitro and in vivo anti-inflammatory activity evaluation. Anna Rita Blanco1, G. Granata2, C. Geraci2, I. Paterniti3, E. Esposito3, S. Cuzzocrea3, G. M. Consoli2. 1SIFI SpA, Lavinaio, Italy; 2Institute of Biomolecular Chemistry, National Research Council (CNR), Catania, Italy; 3 Department of Biological and Environmental Sciences, University of Messina, Messina, Italy *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 273 Tuesday Posters 3:45 pm – 5:30 pm 4020 — B0198 Sustained Release of Travoprost for Glaucoma Therapy via a Biodegradable Wafer, NanoM-TP. Shikha P. Barman1, M. Liu1, K. Crawford2, 1, K. Ward1. 1Drug Delivery, Integral BioSystems, Bedford, MA; 2Preclinical, PharmOcu, LLC, Andover, MA *CR 4023 — B0201 In vitro and In vivo Sustained Release of Dexamethasone from a PRINT Microparticle Suspension. Melissa Sandahl, M. Hernandez, J. Tully, G. owens, R. S. Verhoeven, R. Robeson, S. Williams, R. Schiffman. Envisia Therapeutics, Inc, Morrisville, NC *CR 4036 – 4055 – Tuesday – Posters 4036 — B0214 In vivo fluorescence retinal imaging following AAV2-mediated gene delivery in the rat retina. Joo Yong Lee1, H. Lee2, J. Kim2. 1 Ophthalmology, Asan Medical Center, Seoul; 2 Department of Microbiology, Cellular Dysfunction Research Center, Asan Medical Center, Seoul, Korea (the Republic of) 4037 — B0215 Cell-penetrating peptides as non-invasive drug delivery vehicles for ranibizumab and bevacizumab. Felicity de Cogan1, L. J. Hill1, P. Morgan-Warren1, M. Chen2, R. Scott3, H. Xu2, A. Logan1.1Inflammation and ageing, University of Birmingham, Birmingham, United Kingdom; 2Queens University, Belfast, United Kingdom; 3Moorfields Eye Hospital, Dubai, United Arab Emirates Tuesday Posters 3:45 pm – 5:30 pm 4038 — B0216 Utility of Commercially Available Cationic Lipid-based Delivery of CRISPR-Cas9 to the Retina in vivo. Sandy S. Hung1, V. Chrysostomou4, H. Shen6, F. li2, A. E. King2, J. G. Crowston4, A. Pébay1, B. V. Bui3, G. Liu5, A. W. Hewitt7, 2. 1Neuroregeneration Unit, Centre for Eye Research Australia, East Melbourne, VIC, Australia; 2Menzies Institute for Medical Research, Tasmania, TAS, Australia; 3 Optometry and Vision Sciences, University of Melbourne, Melbourne, VIC, Australia; 4Glaucoma Research Unit, Centre for Eye Research Australia, Melbourne, VIC, Australia; 5Cytoprotection Unit, Centre for Eye Research Australia, Melbourne, VIC, Australia; 6Department of Microbiology, Monash University, Melbourne, VIC, Australia; 7Clinical Genetics Unit, Centre for Eye Research Australia, Melbourne, VIC, Australia 4039 — B0217 A Biodegradable, SustainedReleased, Tacrolimus Microfilm Drug Delivery System for the Management of Allergic Conjunctivitis in a Mouse Model. Yu-Chi Liu1, X. Ng3, H. Ang1, C. Lwin2, S. Venkatraman3, T. T. Wong4, J. S. Mehta1. 1Cornea and External Eye Disease, Singapore Eye Research Institute, Singapore, Singapore; 2Singapore Eye Research Institute, Singapore, Singapore; 3Nanyang Technological University, Singapore, Singapore; 4 Singapore National Eye Centre, Singapore, Singapore 4040 — B0218 Wolfram Syndrome murine models: phenotyping and gene therapy. Jolanta M. Jagodzinska1, 2, D. Bonnet-Wersinger1, S. Koks3, B. Delprat1, 2, C. P. Hamel1, 4, C. DelettreCirballet1, 2.1Institute for Neurosciences of Montpellier, INSERM, Montpellier, France; 2 Univeristy of Montpellier, Montpellier, France; 3 Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia; 4 Ophthalmology, Hôpital Gui de Chauliac, Montpellier, France 4041 — B0219 X-Linked Inhibitor of Apoptosis Gene Therapy Protects Retinal Structure in a Feline Model of Retinal Detachment. Sarah J. Wassmer2, 1, B. C. Leonard3, 1, S. G. Coupland3, 1, J. Hamilton1, A. N. Baker1, L. Fang1, 4, C. Tsilfidis2, 1. 1 Regenerative Medicine, Ottawa Hospital Research Institute, Ottawa, ON, Canada; 2Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; 3Ophthalmology, University of Ottawa Eye Institute, Ottawa, ON, Canada; 4 Ophthalmology, Fujian Medical University Union Hospital, Fujian, China *CR Exhibit/Poster Hall C0087-C0132 Tuesday, May 03, 2016 3:45 PM-5:30 PM Retina 380 Vitreoretinal Interface Disase Moderator: Itay Chowers 4042 — C0087 Ocriplasmin in a porcine model for PVD induction. Bart Jonckx, I. Etienne, T. Janssens, J. H. Feyen. Ophthalmology, ThromboGenics NV, LEUVEN, Belgium *CR 4043 — C0088 Repeated injections of ocriplasmin in the Göttingen mini-pig. Jean H. Feyen1, K. Tenneson2, M. Vezina2, B. Jonckx1. 1 Preclinical Research, ThromboGenics NV, Leuven, Belgium; 2Ocular and Neuroscience, Charles River Laboratories, Montreal, QC, Canada *CR 4044 — C0089 Preclinical insights into ocriplasmin safety and mechanism of action. Michaël PORCU, I. Etienne, A. Candi, A. Verborg, M. Eelen, B. Jonckx, J. H. Feyen. Preclinical Research, ThromboGenics NV, Leuven, Belgium *CR 4045 — C0090 The ocriplasmin for vitreomacular traction intravitreal injection decisions (OVIID-I) trial: full study results. Ramin Tadayoni1, D. C. Carr2, Z. Zhao2. 1Ophthalmology, Hopital LariboisiereOphthalmologie, Paris, France; 2Pharmaceuticals, Alcon Research, Ltd., Fort Worth, TX *CR, f 4046 — C0091 Pharmacologic Closure Rate of Full Thickness Macular Hole with Ocriplasmin—1 year follow-up data. Priya Sharma1, E. Rahimy2, C. D. Regillo3. 1 Ophthalmology Residency, Wills Eye Hospital, Philadelphia, PA; 2Vitreoretinal Fellowship, Wills Eye Hospital, Philadelphia, PA; 3Midatlantic Retina, Wills Eye Hospital, Philadelphia, PA *CR 4047 — C0092 Ocriplasmin for vitreo-macular traction: a Wide-Field OCT Study. Chiara Preziosa, I. D’Agostino, U. Nava, S. Erba, M. G. Cereda, F. Bottoni, G. Staurenghi. Biomedical and Clinical Sciences “Luigi Sacco”, Sacco Hospital, Eye Clinic, University of Milan, Milan, Italy *CR 4048 — C0093 Acute Ocriplasmin Retinopathy (AOR): Electroretinographic (ERG), SD-OCT and clinical features of 6-months monitoring. Katerina Hufendiek, K. Hufendiek, J. Brahms, A. Bajor, C. Framme. University Eye Hospital, Medical School Hannover, Hannover, Germany., Hannover, Germany 4049 — C0094 Clinical results of Ocriplasmin versus C3F8 gas for symptomatic Vitreomacular Traction Syndrome. Katherine Atkins, S. Taylor. Ophthalmology, Royal Surrey County Hospital, Guildford, United Kingdom 4050 — C0095 Evaluation of full-field electroretinogram changes after ocriplasmin injection in a substudy of symptomatic vitreomacular adhesion subjects from the OASIS trial. Joseph I. Markoff1, D. G. Birch2, R. Sergott3, P. Kozma-Wiebe4. 1physiology, Wills Eye Hospital, Moorestown, NJ; 2Retina Foundation of the Southwest, Dallas, TX; 3NeuroOphthalmology, Wills Eye Hospital, Philadelphia, PA; 4ThromboGenics, Leuven, Belgium *CR, f 4051 — C0096 Immune-histochemical characteristics of idiopathic epiretinal membranes. Inge Sarens1, R. Van Ginderdeuren1, 2, P. Stalmans1, J. Van Calster1. 1Ophthalmology, UZ Leuven, Leuven, Belgium;2Pathology, UZ Leuven, Leuven, Belgium 4052 — C0097 Vitreous Biomarkers in Idiopathic Epiretinal Membrane. Parisa Emaminaeini, P. Singh, J. D. Boss, A. Kumar, A. Tewari. Ophthalmology, Kresge Eye Institute, Detroit, MI 4053 — C0098 Paravascular Inner Retinal Defects Associated with Epiretinal Membranes. Akitaka Tsujikawa1, Y. Miyoshi1, S. Manabe1, Y. Nakano1, T. Fujita1, C. Shiragami1, K. Hirooka1, A. Uji2, Y. Muraoka2. 1Ophthalmology, Kagawa Univerisity Faculty of Medicine, Miki, Japan; 2 Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan 4054 — C0099 Changes in Vitreomacular Attachment with Aging: A Comparison Between Healthy Patients and Diabetics. Brooke L. Nesmith, A. C. Palacio, Y. Schaal, A. Gupta, S. Schaal. Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 4055 — C0100 Characteristics of Epiretinal Membrane Remnant Edge by Optical Coherence Tomography after Pars Plana Vitrectomy. Raouf Gaber, Q. You, M. Alam, I. Kilic, N. Mendoza, F. Tsai, W. R. Freeman. Ophthalmology, University of California San Diego, San Diego, CA The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 274 Tuesday – Posters – 4056 – 4076 4056 — C0101 Prevalence of Metamorphopsia in Patients with Vitreomacular Traction and its Impact on Quality of Life: The MeMo Study. Praveen J. Patel1, J. Brazier2, C. Hirneiss3, M. Tangelder4, B. Lescrauwaet5. 1NIHR Biomedical Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom; 2Health Economics and Decision Science, University of Sheffield, Sheffield, United Kingdom;3Department of Ophthalmology, LudwigMaximilians-University, Munich, Germany; 4 Thrombogenics Inc, Leuven, Belgium; 5Xintera Ltd, London, United Kingdom *CR 4057 — C0102 Epiretinal membrane formation following treatment of retinal breaks. Abdallah Jeroudi, K. J. Blinder. Vitreoretinal Surgery and Diseases, The Retina Institute, St. Louis, MO 4058 — C0103 Internal Limiting Membrane Peeling With Chromovitrectomy Induces Retinal Glial Activation. Ahmet Hondur2, 1, Q. Zeng2, T. H. Tezel2. 1Department of Ophthalmology, Gazi University, Ankara, Turkey; 2Ophthalmology, Columbia University College of Physicians and Surgeons, The Edward Harkness Eye Institute, New York, NY 4060 — C0105 Retinal displacement and predictive factors for idiopathic macular hole surgery. Qinghuai Liu, Z. Hu, P. Xie, S. Yuan. Ophthalmology, Nanjing Medical University, Nanjing, China 4061 — C0106 The different type of contraction of epiretinal membrane in lamellar macular hole. Alessandra Acquistapace, M. G. Cereda, M. V. Cigada, F. Bottoni, G. Staurenghi. Biomedical and Clinical Sciences “Luigi Sacco”, Sacco Hospital Eye Clinic, University of Milan, Milan, Italy *CR 4062 — C0107 Optic pit maculopathy Morphological criteria in SD-OCT examination. Klaus Wehrmann, N. Feucht, C. P. lohmann, M. M. Maier. Department of Ophthalmology, TU München, Muenchen, Germany 4064 — C0109 Spanish Retina Society- VMT study: Prevalence Of Vitreomacular Adhesions And Tractions In A Healthy Population Over 45 Years Of Age. Miguel A. Zapata1, M. S. Figueroa2. 1 Retina, Hospital Vall Hebron, Barcelona, Spain; 2 Retina, Hospital Universitario Ramon y Cajal, Madrid, Spain 4065 — C0110 Analysis of the ganglion cell layer-inner plexiform layer thickness after internal limiting membrane peeling in epiretinal membrane, macular hole patients. Jung Min Park1, J. Lee1, S. Lee2.1ophthalmology, Maryknoll medical center, Busan, Korea (the Republic of); 2 Haeundae Paik Hospital, Busan, Korea (the Republic of) 4066 — C0111 Effect of changes in central macular thickness (CMT) and shape on visual acuity after idiopathic epiretinal membrane (ERM) removal. Sung Il Kang. Ophthamology, Kyemyung Univ. Dongsan Medical Center, Daegu, Korea (the Republic of) 4067 — C0112 Functional and morphological assessment of patients with idiopatic epiretinal membrane after surgical treatment. Giancarlo Dell’Aversana Orabona, B. Gallo, A. Orrico, P. Melillo, S. Rossi, F. Testa, M. Della Corte, F. Simonelli. Multidisciplinary department of medicalsurgical and dental specialities, Second University of Naples, Naples, Italy 4068 — C0113 En-face Imaging of epiretinal membrane using swept source optical coherence tomography. Jee Taek Kim. Ophthalmology, Chung Ang University Hospital, Seoul, Korea (the Republic of) 4069 — C0114 Idiopathic macular hole in the fellow eye: prognostic significance of vitreomacular traction at the first examination. Polina Astroz Evtouchenko, E. Philippakis, R. Tadayoni, A. Gaudric. Ophtalmology, Lariboisière Hospital, Paris, France 4070 — C0115 Do peripheral retinal lesions impact the vitreo interface in the posterior pole? Nicola Quinn1, K. Graham1, D. Elliot1, R. Hennessy1, D. Wright2, A. Muldrew1, U. Chakravarthy1, T. Peto3, 4, R. E. Hogg1. 1Centre for Experimental Medicine, Queen’s University Belfast, Fintona, United Kingdom; 2Centre for Public Health, Queen’s University Belfast, Belfast, United Kingdom; 3NIHR Biomedical Research Centre, Moorfield’s Eye Hospital NHS Foundation Trust, London, United Kingdom; 4UCL of Opthalmology London, London, United Kingdom *CR 4071 — C0116 Prevalence of macular abnormalities assessed by Optical Coherence Tomography in patients with Usher Syndrome. Beatrice Gallo1, R. Colucci1, A. De Benedictis1, R. Brunetti-Pierri1, P. Melillo1, S. Rossi1, F. Testa1, C. Azzolini2, M. Della Corte1, F. Simonelli1. 1Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, Second University of Naples, Naples, Italy; 2Section of Ophthalmology, Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy 4072 — C0117 Long term follow-up of fellow eye in patients with lamellar macular hole. Ugo Nava, I. D’Agostino, C. Preziosa, M. G. Cereda, F. Bottoni, G. Staurenghi. Biomedical and Clinical Sciences “Luigi Sacco”, Sacco Hospital Eye Clinic University of Milan, Milan, Italy *CR 4073 — C0118 Early spectral domain optical coherence tomography findings after spontaneous vitreomacular traction release. David Ehmann, A. Shahlaee, E. Rahimy, J. Hsu. Wills Eye Hospital, Philadelphia, PA 4074 — C0119 Real-life experience after intravitreal ocriplasmin for vitreomacular traction and macular hole. Irini Chatziralli1, G. Theodossiadis2, E. Parikakis3, I. Datseris4, P. Theodossiadis1. 12nd Department of Ophthalmology, University of Athens, Athens, Greece; 22nd Department of Ophthalmology, Henry Dunant Hospital, Athens, Greece; 3Ophthalmiatrion Athinon, Athens, Greece; 4OMMA Eye Institute, Athens, Greece 4075 — C0120 Characteristics of the vitreomacular interface diseases assessed by optical coherence tomography. Antonio Ferreras1, 2, P. Ramiro3, P. Calvo1, 2, A. B. Pajarin4, B. Abadia1. 1Ophthalmology, Miguel Servet University Hospital. IIS Aragon, Zaragoza, Spain; 2Ophthalmology, University of Zaragoza, Zaragoza, Spain; 3Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; 4Centro de Salud Seminario, Zaragoza, Spain*CR 4076 — C0121 Lamellar macular hole associated with epiretinal membrane. Clinical and morphological aspects. Elena Zampedri, R. Frisina, F. romanelli. APSS Trento, Multizonal Unit of Ophthalmology, Rovereto, Italy f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 275 Tuesday Posters 3:45 pm – 5:30 pm 4059 — C0104 The effect of spontaneous vs. surgical posterior vitreous detachment (PVD) on epiretinal membrane (ERM) formation in patients undergoing pars plana vitrectomy (PPV) for symptomatic vitreous opacities. Olga Shif1, P. H. Scharper1, M. Ahmed2. 1Ophthalmology, Krieger Eye Institute at Sinai Hospital of Baltimore, Baltimore, MD; 2Ophthalmology, Wilmer Eye Institute at Johns Hopkins, Baltimore, MD 4063 — C0108 ORBIT: A phase IV clinical study - lessons learned from patient selection criteria for ocriplasmin intravitreal injection. Brian C. Joondeph2, 1, J. S. Duker3, 4, D. S. Boyer5, 6, J. S. Heier7, P. K. Kaiser8, M. W. MacCumber9, 10, D. J. Pieramici11, 12. 1Rocky Vista University School of Osteopathic Medicine, Parker, CO; 2Colorado Retina Associates, Denver, CO; 3New England Eye Center, Boston, MA; 4Tufts University School of Medicine, Boston, MA; 5Retina-Vitreous Associates Medical Group, Los Angeles, CA; 6University of Southern California/Keck School of Medicine, Los Angeles, CA; 7Ophthalmic Consultants of Boston, Boston, MA; 8Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 9Illinois Retina Associates, Chicago, IL; 10Rush University Medical Center, Chicago, IL; 11California Retina Consultants, Santa Barbara, CA; 12California Retina Research Foundation, Santa Barbara, CA *CR, f 4077 – 4095 – Tuesday – Posters 4077 — C0122 Noval treatment for newly symptomatic subretinal fluid in X-Linked (Juvenile) Retinoschisis. Gibran S. Khurshid1, S. Mukhtar2, P. Gupta3. 1National Eye Institute, University of Florida, Gainesville, FL; 2VCU School of Medicine, Richmond, VA; 3John hopkins, Baltimore, MD 4078 — C0123 Topography of the Vitreoretinal Interface in Vitreomacular Traction Syndrome. Scott Walter1, D. S. Grewal1, D. Cunefare2, P. K. Bhullar1, S. Farsiu2, T. H. Mahmoud1. 1 Ophthalmology, Duke University Eye Center, Durham, NC; 2Biomedical Engineering, Duke University, Durham, NC *CR Tuesday Posters 3:45 pm – 5:30 pm 4079 — C0124 An assessment of vitreous degeneration in eyes with macular holes and vitreomacular traction. Quraish Ghadiali1, 2, S. Zahid3, M. Engelbert1, 2. 1Ophthalmology, Manhattan Eye Ear & Throat Hospital, New York, NY; 2Vitreous Retina Macula Consultants of New York, New York, NY; 3Ophthalmology, New York University, New York, NY 4080 — C0125 The association between the presence of epiretinal membrane and nerve fiber layer defect in an adult Japanese population: The Chikusei Eye Study. Atsuro Uchida1, M. Sasaki1, 2, Y. Ozawa1, K. Motomura1, K. Yuki1, K. Yamagishi3, N. Sawada4, S. Tsugane4, H. Iso5, K. Tsubota1. 1Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 2Ophthalmology, Tokyo Medical Center, Tokyo, Japan;3Public Health Medicine, University of Tsukuba, Tsukuba, Japan; 4Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan; 5 Public Health, Social and Environmental Health, Osaka University Graduate School of Medicine, Osaka, Japan 4081 — C0126 Tangential Contraction and Early Vision Loss in Idiopathic Epiretinal Membrane Patients. Ik Soo Byon. Pusan National University Yangsan Hospital, Yangsan, Korea (the Republic of) 4082 — C0127 The Evolution of Pre-Existing Epiretinal Membranes Following Cataract Extraction. Kevin Wells, L. Lindsell, G. Reilly. Ophthalmology, Georgetown University Hospital, Washington, DC 4083 — C0128 Correlation Between Degree of Metamorphopsia and Optical Coherence Tomography Findings in Epiretinal Membrane. Sung Yong Park, M. Jung, P. Kim, C. Moon. Ophthalomology, Soonchunhyang Univ. Cheonan Hospital, Cheonan-si, Korea (the Republic of) 4084 — C0129 Internal Limiting Membrane Folding in Epiretinal Membrane: Prevalence, Morphologic Characteristics, and Clinical Implications. Seung Hun Park, S. Ahn, E. Hong, B. Lee. Ophthalmology, Hanyang University Hospital, Seoul, Korea (the Republic of) 4085 — C0130 Vitreoretinal interface abnormalities in older patients with history of retinopathy of prematurity. Aristomenis Thanos1, Y. Yonekawa1, B. Todorich1, B. Thomas1, N. T. Huang2, K. A. Drenser1, M. T. Trese1, A. Capone1. 1 Retina, Associated Retinal Consultants, Royal Oak, MI; 2Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI 4086 — C0131 Vitreous Proteins Implicated in Idiopathic Macular Hole Formation. Sharon D. Solomon1, R. Semba1, P. Zhang1, R. Turner3, J. Qian1, Y. Zhao1, P. A. Campochiaro1, I. E. ZimmerGaller1, I. Han1, Y. M. Paulus2, S. A. Shah1. 1Wilmer Eye Institute Johns Hopkins, Baltimore, MD; 2 Kellogg Eye Center, Ann Arbor, MI; 3University of Maryland, Baltimore, MD 4087 — C0132 Association of Epiretinal Membrane with Development of Lamellar Hole. Seong Joon Ahn, J. Kim, S. Park, B. Lee. Hanyang University, Seoul, Korea (the Republic of) Exhibit/Poster Hall C0162-C0194 Tuesday, May 03, 2016 3:45 PM-5:30 PM Anatomy and Pathology/Oncology 381 Melanoma and Lymphoma: from Models to Man Moderators: Jonathan H. Lin, Gülçin Gezgin and Zelia M. Correa 4088 — C0162 Epidemiological Trends in 1,739 Cases of Orbital Lymphoma in the United States. Siya Huo, M. Andreoli, V. K. Aakalu, P. Setabutr. Ophthalmology, Illinois Eye and Ear Infirmary, Chicago, IL 4089 — C0163 Comprehensive Genomic Profiling of Orbital and Ocular Adnexal Lymphomas Identifies Frequent Alterations in MYD88 and Chromatin Modifiers: New Routes to Targeted Therapies.Rajesh C. Rao1, 2, A. Cani1, M. Soliman1, D. H. Hovelson1, C. Liu1, A. S. McDaniel1, M. J. Haller1, J. Bratley1, S. Rahrig1, C. A. Briceno1, S. A. Tomlins1. 1University of Michigan, Ann Arbor, MI; 2Ophthalmology, VA Ann Arbor Healthsystem, Ann Arbor, MI *CR 4090 — C0164 Diagnostic significance of the vitreous fluid of patients with intraocular B-cell lymphoma. Kenji Nagata1, T. Inaba2, K. Kitazawa3, 1, Y. Sekiyama1, S. Kinoshita3, C. Sotozono1.1Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; 3 frontier medical science and technology for ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan 4091 — C0165 Enhancement of radiation effects on lymphoma cells using gold nanoparticles: an in vitro study and Monte Carlo simulation. Fatemeh Alikarami1, 2, S. Asadi3, S. Balagholi2, 4, M. Rezaeikanavi2, M. Safa1. 1 Department of Hematology, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 2Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of); 3Department of Physics, K. N. Toosi University of Technology, Tehran, Iran (the Islamic Republic of); 4Department of Hematology, Faculty of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of) 4092 — C0166 Clinical features of Systemic metastatic retinal lymphoma in Japanese patients. Rumiko Taki1, A. Takeda1, H. Yoshikawa1, T. Fukuhara1, R. Arita1, Y. Suehiro2, I. Choi2, T. Ishibashi1, K. Sonoda1. 1Ophthalmology, Kyushu University, Fukuoka, Japan; 2Haematology, National Hospital Organization Kyusyu Cancer Center, Fukuoka, Japan f 4093 — C0167 Combined intravitreal methotrexate and immunochemotherapy followed by reduced-dose whole-brain radiotherapy for newly diagnosed primary B-cell intraocular lymphoma. Junko Matsuda1, 2, T. Kaburaki2, R. Tanaka2, M. Takamoto2, H. Nakahara2, K. Ohtomo2, Y. Fujino2, J. Numaga1, H. Yamashita4, M. Kurokawa3, M. Aihara2. 1 Ophthalmology, The Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan; 2Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan; 3 Hematology, The University of Tokyo Hospital, Tokyo, Japan; 4Radiology, The University of Tokyo Hospital, Tokyo, Japan f 4094 — C0168 Repeat Episcleral Plaque Brachytherapy: Clinical Outcomes in Patients Treated for Locally Recurrent Choroidal Melanoma (CM). Benjamin King1, H. Wynn1, B. Gao1, V. M. Morales3, M. T. Ballo2, M. W. Wilson1. 1 Department of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, TN; 2 Department of Radiation Oncology, University of Tennessee Health Sciences Center, Memphis, TN;3Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, TN 4095 — C0169 A new method to determine correct Ruthenium-106 brachytherapy dose to ocular tumor apex using ultrasonography B-scan artifacts. Jens F. Kiilgaard1, C. Espensen1, 2, P. K. Jensen3, L. S. Fog2, K. Klemp1, H. C. Fledelius1, L. Specht2. 1Ophthalmology, Rigshospitalet, Copenhagen, Denmark; 2Oncology, Rigshospitaet, Copenhagen, Denmark; 3Ophthalmology, Roskilde Hospital, Roskilde, Denmark The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 276 Tuesday – Posters – 4096 – 4119 4096 — C0170 Genetic Risk Factors for Radiation Vasculopathy. Thanos D. Papakostas1, A. Lane1, C. Awh1, M. Morrison1, M. M. DeAngelis2, E. S. Gragoudas1, I. K. Kim1. 1Ophthalmology, Massachusetts Eye & Ear Infirmary, Boston, MA; 2 Moran Eye Center, Salt Lake City, UT 4097 — C0171 Radiation retinopathy after proton beam therapy in uveal melanoma. Ira Seibel, A. I. Riechardt, A. Davids, A. Böker, M. Rehak, A. Hager, A. M. Joussen. Charité Universitätsmedizin Berlin, Berlin, Germany 4098 — C0172 Intravitreal Dexamethasone for Recalcitrant CME following Brachytherapy Treatment of Uveal Melanoma. William F. Mieler. Illinois Eye & Ear Infirmary, Chicago, IL 4099 — C0173 High dose (2.5 mg) intravitreal bevacizumab as rescue therapy for persistent post-radiation cystoid macular edema. M. Ali Khan, A. Mashayekhi, K. Ferguson, J. A. Shields, C. L. Shields. Ophthalmology, Wills Eye Hospital, Philadelphia, PA 4100 — C0174 Glaucoma after Iodine-125 Brachytherapy for Uveal Melanoma: Incidence and Risk Factors. Eun-Ah Kim1, M. Kamrava2, J. Lamb2, J. Caprioli1, T. A. McCannel1. 1Jules Stein Eye Institute, Los Angeles, CA; 2Department of Radiation Oncology David Geffen School of Medicine, Los Angles, CA 4102 — C0176 A numerical model to calculate the influence of the viscosity of the vitreous humor during laser-induced thermal damage in choroidal melanomas. Alcides Fernandes1, O. P. Garcia2, P. R. Lyra2, R. C. Lima2. 1Ophthalmology, Emory University, Atlanta, GA; 2Mechanical Engineering, Federal University of Pernambuco, Recife, Brazil 4103 — C0177 Establishment of Orthotopic Lacrimal Gland B-cell Lymphoma Model in Mice. Min Joung Lee1, S. Park2, S. Yoon2, J. Ko2, H. Lee2, M. Kim2, 3, W. Wee2, 3, S. Khwarg3, J. Oh2, 3. 1Ophthalmology, Hallym University Sacred Heart Hospital, Anyang, Korea (the Republic of); 2 Laboratory of Ocular Regenerative Medicine Immunology, Biomedical Research Institute, Seoul, Korea (the Republic of);3Ophthalmology, Seoul National University Hospital, Seoul, Korea (the Republic of) 4104 — C0178 Zeaxanthin inhibits Growth and Invasion of Human Uveal Melanoma in Nude Mouse Model. Dan-Ning Hu1, X. L. Xu2, C. E. Iacob1, A. Jordan1, S. Gandhi1, D. L. Gierhart3, R. B. Rosen1.1New York Eye and Ear Infirmary of Mount Sinai, New York, NY; 2Memorial Sloan-Kettering Cancer Center, New York, NY; 3 ZeaVision LLC, Chesterfield, MT *CR 4106 — C0180 C-Kit Expression in an Animal Model of Uveal Melanoma Mirrors That of Humans. Taylor Nayman, D. Sanft, R. Amade, S. Aldrees, E. Esposito, M. N. Burnier. Ocular Pathology, McGill University, Montreal, QC, Canada 4107 — C0181 Expression of Several Melanoma Markers in a Uveal Melanoma Animal Model. Luiza A. Minussi, C. A. Moreira, J. P. Passos, S. Bakalian, F. Muccioli, M. N. Burnier. McGill, Campinas, Brazil 4108 — C0182 Mouse eye as a model for non-surical investigation of cancer nanotheranostics. Mayank Goswami2, 1, X. Wang1, P. Zhang2, 1, W. Xiao3, Y. Li3, R. J. Zawadzki2, 4, K. Lam3, E. N. Pugh2, 1.1Cell Biology and Human Anatomy, UC Davis, Davis, CA; 2EyePod Mouse Imaging Laboratory, UC Davis, Davis, Afghanistan; 3 Comprehensive Cancer Center, Department of Biochemistry and Molecular Medicine, UC Davis, Sacramento, CA; 4Ophthalmology & Vision Science, UC Davis, Sacramento, CA *CR 4109 — C0183 Verteporfin inhibits growth of human ocular glioma in vitro without light activation. Ahmad Al Moujahed1, K. Brodowska1, T. Stryjewski1, J. Cichy2, E. S. Gragoudas1, D. G. Vavvas1.1Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; 2Dept. of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland *CR 4110 — C0184 The differences in expression of HMB 45, Melan A and COX 2 in canine and human uveal melanoma. Evangelina Esposito, P. M. Barros, E. Perlmann, E. Mayo-Goldberg, A. T. Dias, M. N. Burnier. Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada 4111 — C0185 Assessment of the activity of different AU-011 doses in a xenograft uveal melanoma model. Patrick T. Logan, P. Zoroquiain, S. Aldrees, M. F. Qutub, N. Vila, M. N. Burnier. Pathology, McGill University, Montreal, QC, Canada *CR 4112 — C0186 Expression of SIRT1 in a Uveal Melanoma Animal Model. Debra-Meghan Sanft1, C. Mastromonaco2, A. T. Dias2, M. Burnier3, S. C. Maloney2, M. N. Burnier2. 1Ophthalmology, McGill University, Montreal, QC, Canada; 2Henry C Whitelson Ocular Pathology Laboratory, Montreal, QC, Canada; 3Faculdade de Ciencias Medicas e Saude de Juiz de Fora, Juiz de Fora, Brazil 4113 — C0187 Metastatic Ocular Melanoma to the Liver Exhibits Infiltrative and Nodular Growth Patterns in Mouse Models. Shuo You1, Q. Zhang1, J. lattier2, H. Yang1, S. kang1, H. E. Grossniklaus1.1Emory University, Atlanta, GA; 2MD Anderson Cancer Institute, Houston, TX 4114 — C0188 Ocular metastasis in dogs: a retrospective study of 320 cases. Leandro B. Teixeira, R. R. Dubielzig. Experimental Ophthalmology, UW-Madison Sch of Vet Med, Madison, WI 4115 — C0189 GnRH Expression in Uveal Melanoma as a potential therapeutic target. Juliana Portela Passos, P. Zoroquiain, J. J. Mansure, W. Almajed, O. Dias, M. N. Burnier. Henry C. Witelson Ocular Pathology Laboratory, McGill University, Ancaster, ON, Canada 4116 — C0190 ZEB1 targets multiple malignancy-related components to promote uveal melanoma cell dedifferentiation, proliferation, invasion, and metastasis. Yao Chen2, 1, X. Lu1, D. E. Durango1, D. S. Darling1, L. Gao2, Y. Liu1, D. C. Dean1. 1Department of Periodontics, Endodontics, and Dental Hygiene, University of Louisville, Louisville, KY; 2The Second Xiangya Hospital, Central South University, Changsha, China 4117 — C0191 The effect of oncometabolite 2-hydroxyglutarate on the biological behavior of differentiated melanocytes and uveal melanoma cells. Cindy Weidmann1, C. Quirke1, C. Yao1, C. M. Lowry3, J. Pomerleau1, J. Wagner3, S. Landreville1, 2. 1 Axe médecine régénératrice et Centre universitaire d’ophtalmologie-Recherche, Centre de Recherche du CHU de Québec, Quebec City, QC, Canada; 2 Département d’ophtalmologie, Université Laval, Quebec City, QC, Canada; 3Département de médecine nucléaire et de radiobiologie, Université de Sherbrooke, Sherbrooke, QC, Canada 4118 — C0192 Pharmacological Inhibition of Paxillin Reduces Cell Proliferation in Uveal Melanoma Cell Lines. Bradley Gao1, L. Djenderedjian1, W. Coppess1, Z. Goldsmith1, M. W. Wilson1, 2, V. M. Morales1, 3. 1Ophthalmology, University of Tennessee Health Science Center, Memphis, TN; 2Surgery, St. Jude Children’s Research Hospital, Memphis, TN; 3Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 4119 — C0193 The Effect of varying intensities of Blue Light on The Proliferation of Human Uveal Melanoma Cell-lines. Sultan Aldrees1, 2, P. Zoroquiain1, P. Logan1, V. Bravo-Filho1, J. Coblentz1, M. N. Burnier1. 1Pathology, McGill University, Montreal, QC, Canada; 2Ophthalmology, King Saud University, Riyadh, Saudi Arabia *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 277 Tuesday Posters 3:45 pm – 5:30 pm 4101 — C0175 Extrascleral tumor extension associated with localized scleral melt following plaque brachytherapy for uveal melanoma: histopathologic findings. Chau Pham, S. Couch, G. J. Harocopos. Ophthalmology and Visual Sciences, Washington University in St Louis, St Louis, MO 4105 — C0179 Loss of BAP1 results in high metastatic rate in a mouse ocular melanoma model. Hua Yang1, Z. Li1, Q. Zhang1, C. M. Craven1, S. E. Woodman2, T. A. McCannel3, H. E. Grossniklaus1.1Ophthalmology, Emory University, Atlanta, GA; 2Department of Melanoma Medical Oncology and Systems Biology, University of Texas, MD Anderson Cancer Center, Houston, TX; 3 Ophthalmology, UCLA, Los Angeles, CA 4120 – 4140 – Tuesday – Posters 4120 — C0194 Paxillin regulates UM cell survival by PKC-delta signaling. Vanessa M. Morales1, 2, S. R. Chintalapudi1, Z. Goldsmith1, B. Gao1, P. Mendoza3, H. E. Grossniklaus3, M. W. Wilson1, 4.1Ophthalmology, University of Tennessee Health Science Center, Memphis, TN; 2 Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN; 3Ophthalmology, Emory University, Atlanta, GA; 4Surgery, St. Jude Children’s Research Hospital, Memphis, TN Exhibit/Poster Hall D0001-D0028 Tuesday, May 03, 2016 3:45 PM-5:30 PM Immunology/Microbiology / Clinical/Epidemiologic Research 382 Uveitis Epidemiology Moderators: Ludwig M. Heindl and Steven Yeh Tuesday Posters 3:45 pm – 5:30 pm 4121 — D0001 Thickening of retinal layers in anterior uveitis in the absence of macular edema and epiretinal membranes. Rafael S. Grajewski, K. Burian, C. Cursiefen, L. M. Heindl. Department of Opthalmology, University Eye Clinic Cologne, Cologne, Germany 4122 — D0002 Baseline prognostic factors in patients with Birdshot retinochoriopathy( BRC). Chrysoula Koutsiouki1, A. G. Robson1, 2, G. E. Holder1, 2, A. Rees1, C. Pavesio1, M. C. Westcott1, 3. 1 Medical Retina, Moorfields Eye Hospital, London, United Kingdom; 2Electrodiagnostic, UCL Institute of Ophthalmology, London, United Kingdom; 3 Medical Retina, Institute of ophthalmology, London, United Kingdom *CR 4123 — D0003 One year prediction of low vision in uveitis patients. Mia K. Grand1, 2, H. Putter2, T. Missotten3, K. A. Vermeer1. 1 Rotterdam Ophthalmic Institute, Rotterdam, Netherlands; 2Department of Medical statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands; 3Rotterdam Eye Hospital, Rotterdam, Netherlands 4124 — D0004 Susac’s syndrome: Clinical characteristics, clinical classification and long term prognosis. Ofira Zloto1, J. Chapman2, R. Sheinfeld2, T. Sharon1, R. Huna- Baron1, R. manor3, Y. Shoenfeld4, V. Vishnevskia Dai1. 1Department of Ophthalmology, Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel; 2Department of Neurology and the Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel; 3 Department of Ophthalmology, Rabin Medical center, Petah Tiqva, Israel; 4Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel 4125 — D0005 Uveitic Glaucoma: Longterm Clinical Outcome and Risk Factors for Progression. Yael Sharon1, R. Friling1, 2, M. Lusky1, B. Quizhpe Campoverde3, A. Radgonde3, M. Kramer1.1Ophthalmology, Rabin Medical Center - Beilinson Hospital, Petach-Tikva, Israel; 2Ophthalmology, Schneider Children’s Medical Center of Israel, Petach-Tikva, Israel; 3 Ophthalmology, Hadassah University Hospital, Jerusalem, Israel 4126 — D0006 The Impact Of Applying The Proposed New 2014 International Criteria For Behçet’s Disease: The Birmingham UK Experience. Philip I. Murray1, 2, T. Blake2, D. Carruthers2, E. Damato2, A. K. Denniston1, 2, J. Hamburger1, 2, A. Richards2, A. Poveda-Gallego2, V. Sewell2, D. Mitton2, D. Situnayake2. 1College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; 2 Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom 4127 — D0007 Clinical Characteristics of Multiple Sclerosis Associated Uveitis in the Southeastern United States. Russell W. Read. Ophthalmology, University of Alabama at Birmingham, Birmingham, AL *CR 4132 — D0012 Analysis and outcome of 80 cases of herpetic anterior uveitis at a tertiary referral eye care centre in Singapore. Rosalynn Siantar1, R. Lim1, E. Wong1, S. Ho1, S. Teoh2, R. V. Agrawal1.1Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore, Singapore; 2Eagle Eye Centre, Singapore, Singapore 4133 — D0013 Juvenile idiopathic arthritis - associated uveitis: occurrence and course of ocular hypotony. Arnd Heiligenhaus1, 2, M. Böhm1, 4, C. Tappeiner1, 3, M. Breitbach1, B. ZurekImhoff1, C. Heinz1, 2.1Department of Ophthalmology at St. Franziskus Hospital Münster, Muenster, Germany; 2University of Duisburg-Essen, Essen, Germany; 3Department of Ophthalmology, Inselspital, University, Bern, Switzerland; 4 Department of Ophthalmology, University Clinic, Essen, Germany 4134 — D0014 The demographics and comorbid conditions of patients diagnosed with intermediate uveitis. May Shum, E. Crane, J. S. Kim, E. Kim, D. S. Chu. Institution of Ophthalmology and Visual Sciences, Rutgers New Jersey Medical School, Newark, NJ 4128 — D0008 Malpractice Litigation in Uveitis and Ocular Inflammation. Ashvini Reddy1, S. B. Engelhard2, C. Shah2, A. Sim2. 1 Ophthalmology, Wilmer Eye Institute, Johns Hopkins, Baltimore, MD;2Ophthlamology, University of Virginia, Charlottesville, VA 4135 — D0015 Syphilitic Uveitis in Orange County, California, 2015: A Case Series. Doran Spencer1, C. Ried4, A. Pirouz2, A. Lam3, S. Lu1, M. Mehta1. 1Ophthalmology, UC Irvine, Orange, CA; 2 Retinal Consultants of Orange County, Fullerton, CA; 3St Jude Medical Center, Fullerton, CA; 4 Orange County Health Care Agency, Santa Ana, CA 4129 — D0009 Clinical characteristics of Japanese patients with scleritis. Rie Tanaka, K. Ohtomo, M. Takamoto, K. Komae, J. Numaga, Y. Fujino, M. Aihara, T. Kaburaki. Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Japan 4136 — D0016 Chronic manifestations of Vogt-Koyanagi-Harada disease. On-Tat Lee, H. A. Aziz, J. Tan, J. L. Berry, D. C. Rodger, N. A. Rao. Ophthalmology, USC Eye Institute, Los Angeles, CA 4130 — D0010 JIA & Uveitis: The Patients’ Perspective. Brian Do1, 2, N. V. Nayak1, S. Kedhar1, C. Samson1. 1Ophthalmology, The New York Eye & Ear Infirmary of Mount Sinai, New York, NY;2Ophthalmology, The Icahn School of Medicine at Mount Sinai, New York, NY 4137 — D0017 Association of Vitamin D Levels with Non-infectious Uveitis. Lindsay Grotting, S. Davoudi, G. Papaliodis, L. Sobrin. Harvard Department of Ophthalmology, Massachusetts Eye and Ear, Boston, MA 4131 — D0011 Longitudinal vision related quality of life in patients with non-infectious uveitis. Elizabeth A. Sugar1, V. Venugopal5, J. E. Thorne4, K. D. Frick2, G. N. Holland3, R. C. Wang6, A. Robert3, J. T. Holbrook5. 1Department of Biostatistics, Bloomberg Sch Public Hlth-JHU, Baltimore, MD; 2Cary Business School, Johns Hopkins University, Baltimore, MD; 3Jules Stein Eye Institute, UCLA, Los Angeles, CA; 4Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; 5Epidemiology, Johns Hopkins University, Baltimore, MD; 6Texas Retina Associates, Dallas, TX *CR, f 4138 — D0018 Multimodal Imaging Of Kyrieleis Plaques. Paola Carrai2, F. Pichi3, 1, A. Invernizzi4, A. Mantovani6, F. Ricci5, G. Staurenghi4, S. K. Srivastava3. 1San Giuseppe Hospital, Milan, Italy; 2University of Milan, Milan, Italy; 3Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 4 Ospedale Sacco, Milan, Italy; 5Tor Vergata, Roma, Italy; 6Ospedale Valduce, Como, Italy 4139 — D0019 The Bronx Epidemiology of Uveitis Study (BEUS): A Clinic-based CaseControl Study of Uveitis and Potential Associated Risk Factors. Stephen Walters, J. Powell, J. Koelhoffer, D. C. Gritz. Ophthalmology, Montefiore Medical Center, New York, NY 4140 — D0020 Ocular manifestations in patients diagnosed with granulomatosis with polyangiitis. Ana K. Escalona Brito, M. PedrozaSeres, R. Bobadilla. Ophthalmology, Instituto De Oftalmologia Conde De Valenciana, DF, Mexico The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 278 Tuesday – Posters – 4141 – 4159 4141 — D0021 What about the ocular inflammation in the elderly? Alejandro J. Zermeno-Arce1, R. Bobadilla2, M. Pedroza-Seres2, R. Moreno-Mendoza1. 1General Ophthalmology, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico; 2Uveitis and Ocular Inflammation, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico 4142 — D0022 Traumatic Uveitis Following Blunt Ocular Trauma and Complications. Ricardo Moreno-Mendoza1, M. Pedroza-Seres2, R. Bobadilla2, M. Almanza1, A. J. Zermeno-Arce1. 1 General Ophthalmology, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico; 2 Uveitis and Ocular Inflammation, Instituto de Oftalmología Conde de Valenciana, Mexico City, Mexico 4143 — D0023 Characteristics of Multiple Sclerosis Associated Uveitis. Himanshu Banda, C. Stelton, S. Yeh. Ophthalmology, Emory University, Atlanta, GA *CR 4144 — D0024 Birdshot’s chorioretinopathy: a proposed morphological classification. Florence Hoogewoud2, 1, S. Salah2, M. Guillard2, C. Bonnet2, A. P. Brezin2, D. Monnet2. 1Geneva University Hospital, Geneva, Switzerland; 2Cochin University Hospital, Paris, France 4146 — D0026 Vogt Koyanagi Harada Syndrome a review of 114 patients in Mexican population. Rosalva Bobadilla, M. Pedroza-Seres. Hospital Conde de Valenciana, Coacalco, Mexico 4147 — D0027 Novel Risk Factors for Ocular Manifestations of Sarcoidosis in an Urban Population. Devi Mehrotra, E. J. Schwaber, J. Powell, T. Aldrich, D. C. Gritz. Montefiore Med Ctr-Albert Einstein Coll of Med, Bronx, NY 4148 — D0028 Familial Cases of birdshot Chorioretinopathy: genetic and epidemiology. Clémence Bonnet, D. Monnet, A. P. Brezin. Ophtalmologie, Hopital Cochin, Paris, France Tuesday, May 03, 2016 3:45 PM-5:30 PM Retina 383 Macular Edema Clinical and Translational Moderator: Giuseppe Querques 4149 — D0063 Repeated Dexamethasone Implants in Patients with Refractory Macular Edema Receiving Anti-VEGF Therapy. Betsy Colon, M. Busquets, P. Matthew. Retina, Associates in Ophthalmology, Pittsburgh, PA 4150 — D0064 Dexamethasone implant with rescue ranibizumab for treating macular edema secondary to retinal vein occlusion. Sundeep Kasi, E. Rahimy, J. A. Haller, A. Shahlaee. Retina, Wills Eye Hospital, Philadelphia, PA *CR, f 4151 — D0065 Twelve-Month Follow-Up Of Dexamethasone Implants For Macular Edema From Various Diseases In Vitrectomized And Non-Vitrectomized Eyes: Results From The Pan American Collaborative Retina Study Group. Renata T. Kato1, E. A. Novais1, M. Maia1, P. A. Mello Filho1, J. R. Dias1, M. Avila5, A. Maia1, J. Arevalo4, L. Wu2, M. H. Berrocal3, M. Farah1. 1 Federal University of Sao Paulo, Sao Paulo, Brazil; 2 Asociados de Macula, Vitreo y Retina de Costa Rica, San Jose, Costa Rica; 3University of Puerto Rico, San Juan, PR; 4Wilmer Eye Institute, John Hopkins University, MD; 5Federal University of Goiás, Sao Paulo, Brazil *CR 4152 — D0066 A 12-Month, Open-Label, Multicenter Study to Assess the Safety and Efficacy of Ozurdex 0.7 mg for the Treatment of Macula Edema Related to Branch Retinal Vein Occlusion in Korea; the COBALT Study. Young Hee Yoon1, J. Kim4, D. Chang2, S. Simonyi3, J. LEE1. 1 Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea (the Democratic People’s Republic of);2Allergan, Seoul, Korea (the Democratic People’s Republic of); 3 Medical Affairs, Allergan, Singapore, Singapore; 4 Ophthalmology, Kim’s Eye Hospital, Konyang University College of Medicine, Seoul, Korea (the Democratic People’s Republic of) *CR, f 4153 — D0067 Dexamethasone implant (Ozurdex©) intraocular pressure outcomes in the real-world. Javier Zarranz-Ventura1, 2, A. Sala-Puigdollers1, D. Velazquez Villoria3, M. Figueras-Roca1, S. Copete3, L. N. Distefano3, A. Boixadera Espax3, J. Garcia-Arumi3, A. Adan Civera1. 1Ophthalmology, Hospital Clinic Barcelona, Barcelona, Spain; 2Medical Retina Service, Moorfields Eye Hospital, London, United Kingdom; 3Retina Service, Hospital Vall de Hebron, Barcelona, Spain *CR 4154 — D0068 Staged Combination Therapy using Ranibizumab and Ozurdex for Retinal Vein Occlusion Macular Edema: The RandO Protocol. Peter Cikatricis1, A. Sarmad1, B. Mushtaq1, S. Elsherbiny1, R. Chavan1, E. Damato1, A. Mitra1, Y. C. Yang1, 2, P. Lip1. 1Birmingham Midland Eye Centre, Birmingham, United Kingdom; 2Wolverhampton Eye Infirmary, Wolverhampton, United Kingdom 4155 — D0069 Bevacizumab in the treatment of macular edema complicating retinal vein occlusions. Julio A. Urrets-Zavalia1, M. GonzalezCastellanos1, E. Esposito1, 2, N. Crim1, L. Correa1, D. Martinez1, M. Barros-Centeno1, H. M. Serra3. 1 Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Cordoba, Argentina; 2Henry C. Wittelson Eye Pathology Laboratory, McGill University, Montreal, QC, Canada; 3CIBICI-CONICET, Faculty of Chemical Sciences, Universidad Nacional de Cordoba, Cordoba, Argentina 4156 — D0070 Comparing bevacizumab, ranibizumab, and aflibercept for early reduction of macular edema in patients with retinal vein occlusions (RVO). Michael E. Jansen1, L. Tyler1, D. Kermany2, J. Waters1, M. Singer2. 1Ophthalmology, University of Texas Health Science Center, San Antonio, TX; 2Medical Center Ophthalmology Associates, San Antonio, TX *CR 4157 — D0071 Clinical management of macular edema secondary to retinal vein occlusion by retina specialists in clinical practice in Spain: OBSERVAR Study. Carmen Navarro Darder1, M. Abraldes3, A. Pareja2, M. Roura1, B. Romero1. 1Novartis Pharma, Barcelona, Spain; 2 Hospital Universitario de Canarias, Tenerife, Spain; 3 Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain *CR 4158 — D0072 Anti-VEGF treatment of macular edema using a treat-and-extend regimen in retinal vein occlusion in clinical practice. Manar Addou Regnard, A. Glacet-Bernard, R. Mascali, E. H. Souied. Ophthalmology, Hôpital Intercommunal de Créteil, University Paris Est, Créteil, France 4159 — D0073 Management of macular edema secondary to RVO with visual impairment in real-life practice in France: Findings from the cross-sectional BOREAL RVO study. Audrey Derveloy1, A. Glacet Bernard2, F. Fajnkuchen3, C. P. Garcher4, J. Girmens5, L. Kodjikian9, C. Delcourt7, P. Guillausseau8, P. Massin6. 1Novartis Pharma SAS, Rueil-Malmaison, France; 2Centre Hospitalier Intercommunal de Créteil, Créteil, France; 3Ophtalmology, Hopital Avicenne, Bobigny, France; 4Ophtalmology, CHU Dijon, Dijon, France; 5Hopital des Quinze-Vingt, Paris, France; 6 Ophtalmology, Hopital Lariboisiére, Paris, France; 7 ISPEP, Bordeaux, France; 8Hopital Lariboisiére, Paris, France; 9Ophtalmology, Hospice Civils de Lyon, Lyon, France *CR f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 279 Tuesday Posters 3:45 pm – 5:30 pm 4145 — D0025 Patterns of Ocular Manifestations in Ebola Virus Disease Survivors in the Port Loko, Sierra Leone. Matthew Vandy1, J. Mattia1, J. Chang2, D. Platt2, Y. Mansaray3, A. Kamara3, R. Pinto6, D. Bausch4, J. Shantha5, S. Yeh5, K. Dierberg2. 1Lowell and Ruth Gess Eye Hospital, Freetown, Sierra Leone; 2Partners in Health, Boston, MA; 3Lunsar Baptist Eye Hospital, Port Loko, Sierra Leone; 4World Health Organization, Geneva, Switzerland; 5Emory Eye Center, Atlanta, GA; 6University of Toronto, Toronto, ON, Canada Exhibit/Poster Hall D0063-D0098 4160 – 4182 – Tuesday – Posters 4160 — D0074 Real World Comparison Of Ranbiziumab And Bevacizumab For Macular Edema Secondary To Retinal Vein Occlusions. Mehnaz Khan, K. M. Wai, F. Q. Silva, S. K. Srivastava, J. P. Ehlers, A. Rachitskaya, R. Deasy, A. Schachat, P. K. Kaiser, A. Yuan, R. P. Singh. Cole Eye Institute, Cleveland Clinic, Cleveland, OH *CR 4168 — D0082 Correlation of diabetic macular edema intraretinal cyst reflectivity on SD-OCT to anti-VEGF treatment response. Nathan R. Haines1, R. Sanders2, R. Y. Hwang1, J. Olson1. 1 Ophthalmology, University of Colorado Health Eye Center, Denver, CO; 2Mercer University School of Medicine, Macon, GA 4175 — D0089 Increased Frequency of Topical Steroids Provides Benefit in Treatment of Postsurgical Cystoid Macular Edema. Saleema A. Kherani, Y. S. Han, G. Hafiz, C. Krispel, T. A. Liu, T. A. Mir, P. A. Campochiaro. Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD *CR, f 4161 — D0075 Retina specialists treating cystoid macular edema secondary to retinal vein occlusion recommend different treatments for patients than they would choose for themselves. Marlene D. Wang1, S. P. Shah1, 2, K. W. Jeng1, H. Feng1, H. F. Fine1, 2, J. L. Prenner1, 2. 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ; 2NJ Retina, New Brunswick, NJ *CR 4169 — D0083 Optical coherence tomography of macular edema in uveitis and retinal vein occlusion: a comparative study. Pierre Sustronck, N. Massamba, V. Touitou, P. Lehoang, B. Bodaghi. Pitié-Salpetrière, Charenton le Pont, France 4176 — D0090 Dexamethasone intravitreal implant for macular edema associated with retinitis pigmentosa. Junghyun Park1, H. Yu2. 1 Ophthalmology, Seoul Paik Hospital, Inje University, Seoul, Korea (the Republic of); 2 Ophthalmology, Seoul National University, Seoul, Korea (the Republic of) 4162 — D0076 Real world clinical audit of aflibercept for management of macular edema secondary to central retinal vein occlusion. Kaivon Pakzad-Vaezi1, M. El-Atfy2, E. Vrizidou1, P. Addison1. 1Medical Retina, Moorfields Eye Hospital, London, United Kingdom; 2University College London, London, United Kingdom *CR Tuesday Posters 3:45 pm – 5:30 pm 4163 — D0077 Individualized ranibizumab dosing effective for maintaining visual acuity gains in patients with BRVO and CRVO. Mimi Liu1, P. Wang2, Z. Haskova2. 1Colorado Retina Associates, Denver, CO; 2Genentech, Inc, South San Francisco, CA *CR, f 4164 — D0078 Presence of subretinal fluid at baseline preserves from photoreceptor alterations in diabetic macular edema and cystoid macular edema due to central retinal vein occlusion. Ana-Maria Philip1, D. Podkowinski1, E. Pablik2, A. Montuoro1, S. M. Waldstein1, B. Gerendas1, U. Schmidt-Erfurth1. 1 Christian Doppler Laboratory for Ophthalmic Image Analysis, Department of Ophthalmology, Vienna Reading Center, Vienna, Austria, Vienna, Austria; 2Center for Medical Statistics, Informatics, and Intelligent Systems Medical University Vienna, Vienna, Austria *CR, f 4165 — D0079 Correlation of Subfoveal Choroidal Thickness with Change in Central Foveal Thickness and BCVA in Hispanic and Caribbean Patients Treated with Anti-VEGF for Diabetic Macular Edema. Amy Mehta, B. B. Johnson, P. Rosenbaum, J. Levine. Ophthalmology, Bronx Lebanon Hospital Center, New York, NY 4166 — D0080 Predictive factors for visual outcome and risk factors for persistent macular edema in patients with branch retinal vein occlusion. Taneto Tomiyasu, Y. Hirano, N. Suzuki, M. Yoshida, A. Uemura, T. Yasukawa, Y. Ogura. Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 4167 — D0081 Predictive Value of Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Retinal Vein Occlusion. Anton M. Kolomeyer, Y. Ling, E. Duerr, G. Wollstein, J. N. Martel. UPMC, Pittsburgh, PA 4170 — D0084 Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) in Patients with Central Retinal Vein Occlusion (CRVO) and Cystoid Macular Edema (CME): A SCORE2 Ancillary Study.Shane Griffin9, A. Roorda1, M. M. Chung2, H. Song2, J. Carroll3, J. I. Morgan4, T. Chui5, 6, R. B. Rosen5, B. A. Blodi7, I. U. Scott8, J. L. Duncan9. 1School of Optometry and Vision Science Graduate Group, University of California at Berkeley, Berkeley, CA; 2Flaum Eye Institute, Center for Visual Science, University of Rochester, Rochester, NY; 3Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, WI; 4Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA; 5Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY; 6Icahn School of Medicine at Mount Sinai, New York, NY; 7Department of Opthalmology and Visual Sciences, University of Wisconsin Madison, Madison, WI; 8Hershey Eye Center, Penn State, Hershey, PA; 9Department of Ophthalmology, University of California San Francisco, San Francisco, CA *CR, f 4171 — D0085 Baseline and sequential predictors of chronic refractory macular edema secondary to branch retinal vein occlusion after anti-VEGF; a long-term follow-up study. June-Gone Kim, B. Moon, J. LEE, Y. Yoon. Ophthalmology, Asan Medical Center, Seoul, Korea (the Republic of) 4172 — D0086 Two cases of unexpected radiation retinopathy: one after 20 Gy orbital and one after 30 Gy whole-brain radiation. Katarina Hurtikova1, S. Tschuppert1, H. Gerding1, 2. 1 Departement of Ophthalmology, Pallas Klinik, Olten, Switzerland; 2Department of Ophthalmology, University of Münster, Münster, Germany 4173 — D0087 Reduction of macular edema from radiation retinopathy using intravitreal dexamethasone-implant (Ozurdex®). James Snitzer, S. C. Oliver. Ophthalmology, University of Colorado Denver, Denver, CO *CR 4174 — D0088 A Retrospective Observational Study on the Prevalence of Pseudophakic Cystoid Macular Oedema (CMO) in a Diabetic Population. Elizabeth M. Walsh1, R. D. Hamilton2, 1, C. Pavesio2, 1.1Medical Retinal, Moorfields Eye Hospital, London, United Kingdom; 2NIHR BRC at Moorfields Eye Hospital, London, United Kingdom *CR 4177 — D0091 Drug-induced macular edema. Victor Llorens, M. Mesquida, B. Molins, J. Matas, A. Sala-Puigdollers, J. Zarranz-Ventura, M. Sainz De La Maza, A. Adan Civera. Clínic Institute of Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain 4178 — D0092 Relationship Between Prostaglandin Analog Use and Cystoid Macular Edema. Kam Vaziri1, S. Pershing2, K. S. Kishor1, S. G. Schwartz1, 3, H. W. Flynn1, J. Fortun1, D. M. Moshfeghi2, A. A. Moshfeghi4. 1Ophthalmology, Bascom Palmer Eye Insititue, Palm Beach Gardens, FL; 2Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA; 3 Ophthalmology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; 4Ophthalmology, USC Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, CA 4179 — D0093 Characterization of DL-2-aminoadipic acid-induced retinal neovascularization and leakage in nonhuman primates. W. Hu, R. Brookes, A. Lewis, V. Woodley, D. James, S. Henry, R. J. Goody, J. Attwood, M. S. Lawrence, Wenzheng Hu. RxGen, Inc., Hamden, CT *CR 4180 — D0094 Aqueous Angiopoietin-like 4 Levels Correlate with Nonperfusion Area and Macular Edema in Branch Retinal Vein Occlusion. Dong Ho Park, J. Kim, J. Im, J. Shin, I. Kim. Ophthalmology, Kyungpook National Univ Hospital, Daegu, Korea (the Republic of) 4181 — D0095 Analysis of Aqueous Cytokines According to Naïve Diabetic Macular Edema Patterns as based on Optical Coherence Tomography. Jin Young Kim1, W. Lee2, S. Park2. 1 Ophthalmology, Department of Ophthalmology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea (the Republic of); 2Ophthalmology, Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea (the Republic of) 4182 — D0096 Aqueous humour Biomarkers:Bespoke Therapeutical approach to Macular edema in Retinal Vein Occlusions(ABVO study). Neha Sudhakar Peraka. Retina Ophthalmology, Narayana Nethralaya, Bangalore, India The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 280 Tuesday – Posters – 4183 – 4201 4183 — D0097 Increased FXII activity in vitreous of patients with Diabetic Macular Edema (DME) and in animal models of VEGFand bradykinin-induced retinal edema. Tuna Ustunkaya, N. Murugesan, A. C. Clermont, E. P. Feener. Vascular Biology, Joslin Diabetes Center, Boston, MA 4184 — D0098 In vitro effects of interleukin-6 on the outer blood-retinal barrier. Marina Mesquida2, 1, P. J. Lait3, D. A. Copland3, J. Liu3, V. Llorens1, M. Sainz De La Maza1, A. Adan Civera1, A. D. Dick3, R. W. Lee3, 4, B. Molins2. 1 Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain; 2Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain; 3School of Clinical Sciences, University of Bristol, Bristol, United Kingdom;4Biomedical Research Centre at Moorfields Eye Hospital, National Institute for Health Research, London, United Kingdom *CR Exhibit/Poster Hall D0204-D0234 Tuesday, May 03, 2016 3:45 PM-5:30 PM Retinal Cell Biology / Glaucoma / Lens / Nanotechnology and Regenerative Medicine 384 Müller Cells and Astrocytes In Development and Disease Moderator: Patrice E. Fort 4186 — D0205 Tumor suppressor p27KIP1 modulates cell-cycle entry and limited neurogenic potential in radial Müller glia. Edward Levine1, 2, D. M. Defoe3, F. Vazquez-Chona2. 1 Vanderbilt Eye Institute, Vanderbilt University, Nashville, TN; 2Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT; 3Biomedical Sciences, ETSU College of Medicine, Johnson City, TN 4187 — D0206 Pharmacologic Inhibition of Intermediate Filament Accumulation in Astrocytes and Müller Glia Mediates Retinal Neuroprotection. Jeremy M. Sivak1, 2, D. Chan1, 2, X. Guo1, I. Livne-Bar3.1Vision Sciences, Krembil Research Institute, University Health Network, Toronto, ON, Canada; 2Vision Sciences and Ophthalmology, University of Toronto, Toronto, ON, Canada; 3School of Optometry, University of California at Berkeley, Berkeley, CA *CR 4189 — D0208 The Role of Notch Signaling in the Regenerating Adult Zebrafish Retina. Joshua Hobgood. Biology, University of Notre Dame, South Bend, IN 4190 — D0209 Changes in miRNAs in Müller glia after retinal injury and Dicer deletion. Stefanie G. Wohl, T. A. Reh. Biological Structure, University of Washington, Seattle, WA 4191 — D0210 Müller cell processes occupy the subretinal space in geographic atrophy and Stargardt disease. Malia M. Edwards1, D. McLeod1, I. A. Bhutto1, R. Grebe1, M. Villalonga3, V. L. Bonilha2, J. G. Hollyfield2, J. M. Seddon3, 4, G. A. Lutty1. 1Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; 2 Cole Eye Institute, Cleveland Clinic, Cleveland, OH; 3Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Boston, MA; 4Ophthalmology, Tufts University School of Medicine, Boston, MA 4192 — D0211 Gliotic remodeling in long-term organotypic culture of the human retina. Arnold Szabo1, M. Hudak1, A. Kusnyerik2, A. Lukats1, Z. Nagy2, J. Nemeth2, A. Szel1. 1Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary; 2 Department of Ophthalmology, Semmelweis University, Budapest, Hungary 4193 — D0212 Inhibition of Muller Cell Circadian Rhythms by siRNA Knockdown of Period Genes. Lili Xu2, A. Liu3, J. S. Penn1, D. McMahon2. 1Ophthalmology, Vanderbilt University, Nashville, TN;2Biological Sciences, Vanderbilt University, Nashville, TN; 3Department of Biology, University of Memphis, Memphis, TN 4194 — D0213 ChR2 Stimulation in Müller cells Modulates the Retinal Light Response. Cameron Baker, J. Tang, M. Berry, E. Isacoff, J. G. Flannery. Technology, Univeristy California Berkeley, Berkeley, CA 4195 — D0214 The role of FAK in fibrotic matrix contraction by dedifferentiated Müller cells. Rintaro Tsukahara1, K. Umazume2, N. Yamakawa2, T. Iwasaki1, H. J. Kaplan3, H. Goto2, S. Tamiya3, 4.1Ophthalmology, Tokyo Med Univ, Ibaraki Med Ctr, Inashikigun, Japan; 2 Ophthalmology, Tokyo Med Univ, Shinjuku, Japan; 3 Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY; 4Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 4196 — D0215 Role of Dexamethasone preventing Müller glial cells swelling. Lourdes M. Siqueiros1, 2, H. Charles-Messance1, R. Bolanos3, 4, C. Montañez2, J. Sahel1, 5, A. Rendon1, R. Tadayoni1, 6, A. Giocanti7. 1Institut de la Vision/ INSERM/UPMC Univ Paris 06/CNRS/CHNO des Quinze-vingts, Paris, France; 2Genetics and Molecular Biology, CINVESTAV, Mexico, Mexico; 3 Association to prevent blindness in Mexico, Dr. Luis Sanchez Bulnes Hospital, Mexico, Mexico; 4 Ophthalmology, Regional Hospital, Adolfo López Mateos, ISSSTE, Mexico, Mexico; 5Fondation Ophtalmologique Adolphe de Rothschild, Paris, France; 6Ophthalmology, Hôpital Lariboisière, AP-HP, Univ Paris Diderot, Paris, France; 7 Ophthalmology, Avicenne hospital, Bobigny, France 4197 — D0216 Coordinating reactive gliosis and regeneration following damage to the adult zebrafish retina. Ryan Thummel2, J. L. Thomas1, A. H. Ranski2, G. W. Morgan3. 1Department of Biological Structure, University of Washington, Seattle, WA; 2Department of Anatomy/Cell Biology and Ophthalmology, Wayne State University School of Medicine, Detroit, MI; 3Department of Biochemistry, University of Washington, Seattle, WA 4198 — D0217 Implication of 24-S-hydroxycholesterol in Müller glial cell’s membrane dynamics in the rat. Arthur Ferrero1, S. Gambert-Nicot2, N. Acar2, A. M. Bron1, 2, L. Bretillon2, C. P. Garcher1, 2.1Ophthalmology, University Hospital Dijon, France, Dijon, France; 2 CSGA, UMR1324 INRA, 6265 CNRS, Burgundy University, Eye and Nutrition Research Group, Dijon, France 4199 — D0218 The effect of systemic administration of methylene blue and metformin on photoreceptor degeneration caused by selective Müller cell disruption. Weiyong Shen, M. X. Yam, S. Lee, Y. Wang, S. Chung, L. Zhu, M. C. Gillies. Save Sight Institute, The University of Sydney, Sydney, NSW, Australia 4200 — D0219 The influence of X-box Binding Protein 1 and the Unfolded Protein Response on Müller glia differentiation into retinal neurons. Todd McLaughlin1, 2, J. Yang1, 4, J. J. Wang1, 2, S. X. Zhang1, 3. 1Departments of Ophthalmology and Ross Eye Institute, University at Buffalo, State University of New York, Buffalo, NY; 2SUNY Eye Institute, State University of New York, Buffalo, NY; 3Department of Biochemistry, University at Buffalo, State University of New York, Buffalo, NY; 4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China 4201 — D0220 Retinal degeneration triggers the activation of the Hippo pathway effector gene YAP in reactive Müller cells. christel Masson-Garcia, A. Hamon, J. Bitard, J. E. Roger, M. Perron. Institute of Neuroscience, CNRS, Certo, Orsay, France f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 281 Tuesday Posters 3:45 pm – 5:30 pm 4185 — D0204 Repopulation of the retina by myeloid cells following depletion of endogenous retinal microglia in adult mice. Yikui Zhang, L. Zhao, X. Wang, R. N. Fariss, W. T. Wong. National Eye Institute, Bethesda, MD 4188 — D0207 Effect of TNF-α on the expression of glial fibrillary acidic protein (GFAP) and on the photoreceptor differentiation of human Müller glial stem cells in vitro. Erika Aquino, K. Eastlake, A. Angbohang, P. T. Khaw, G. Limb. NIHR Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology and Moorfields Eye Hospital, London, United Kingdom 4202 – 4221 – Tuesday – Posters 4202 — D0221 Müller cell-derived YAP signaling as a new neuroprotective pathway in the degenerating retina. Annaïg Hamon2, 1, J. E. Roger2, 1, J. Bitard2, 1, C. Masson-Garcia2, 1, E. Grellier2, 1, M. Perron2, 1. 1Certo, Orsay, France; 2 Neuro-Psi, Orsay, France 4203 — D0222 Lin28a regulates retinal neurogliogenesis and confers ectopic neural potential on Müller glia. Xiaohuan Xia, I. Ahmad. Ophthalmology and Visual Science, Univ of Neb Med Center, Omaha, NE Tuesday Posters 3:45 pm – 5:30 pm 4204 — D0223 Impact of a reduction of plasmalogen levels on Müller cell metabolism. Charlotte Pallot1, J. Mazzocco2, S. Gregoire2, L. Leclere2, B. Buteau2, A. M. Bron1, 2, C. P. Garcher1, 2, L. Bretillon2, N. Acar2. 1Ophthalmology, University hospital, Dijon, France; 2INRA, Eye and Nutrition research group, Dijon, France 4205 — D0224 Immunolocalization of Gap Junction Protein Connexin 43 (GJA1) in retina and Glial Müller Cells in WT and Dp-71 null mice. Rodrigo Bolanos1, 2, L. M. SIQUEIROS3, Y. Garfias4, 5, C. Montañez6, J. Sahel3, X. P. Guillonneau3, A. Rendon3. 1Anterior Segment Department, Association to Prevent Blindness in Mexico, Dr Luis Sánchez Bulnes, Mexico, Mexico; 2 Ophthalmology Service, Regional Hospital, Adolfo López Mateos, ISSSTE, Mexico, Mexico; 3 Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Institut de la Vision, Paris, France; 4Department of Biochemistry, Faculty of Medicine. Universidad Nacional Autónoma de México, UNAM., Mexico, Mexico; 5Research Unit, Institute of Ophthalmology “Conde de Valenciana”, Mexico, Mexico; 6 Department of Genetics and Molecular Biology, CINVESTAV, Mexico, Mexico 4206 — D0225 Glucose effect on Rat and Human Müller Cells Viability and VEGF Secretion. Sandeep Vellanki1, A. Ferrigno2, Y. Alanis1, B. S. Betts-Obregon1, A. T. Tsin1. 1Biology, University of Texas at San Antonio, San Antonio, TX; 2Escuela de Medicina, Tecnologico de Monterrey, Monterrey, Mexico 4207 — D0226 Plasmalogens and cell-cell communication between retinal glial cells. Julie Mazzocco1, C. Pallot2, B. Buteau1, S. Gregoire1, L. Leclere1, A. M. Bron2, C. P. Garcher2, L. Bretillon1, N. Acar1.1Eye & Nutrition Research Group, Dijon, France; 2ophthalmology, university hospital, Dijon, France 4208 — D0227 Primary muller glial cultures of primate origin. Shweta Singhal1, 2, V. Pakala2, M. N. Mehta2, V. A. Barathi2, T. Wong1, 2. 1Singapore National Eye Centre, Singapore, Singapore; 2Retina, Singapore Eye Research Institute, Singapore, Singapore 4209 — D0228 TRPV4 and TRPC1 channels regulate strain sensitivity in retinal neurons and glia. Andrew Jo, S. Redmon, A. Iuso, T. Molnar, T. T. Phuong, D. Krizaj. Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, UT 4210 — D0229 Retinal Ganglion Cells Control Spatial Patterning of Astrocytes During Development. Matthew L. O’Sullivan1, J. A. Brzezinski3, T. M. Glaser4, J. Kay1, 2. 1Neurobiology, Duke University School of Medicine, Durham, NC; 2Ophthalmology, Duke University School of Medicine, Durham, NC; 3Ophthalmology, University of Colorado School of Medicine, Aurora, CO; 4Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, CA 4211 — D0230 Endothelin-1 Induced the Reactivation of Primary Rat Ocular Astrocytes. Shaoqing He1, H. Ma1, Y. H. Park1, J. Wang2, T. Yorio1. 1North Texas Eye Research Institute, University of North Texas Hlth Sci Ctr, Fort Worth, TX; 2Depart. of Ophthalmology, TongJi Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4212 — D0231 Sigma-1 receptor mediated secretion of BDNF by optic nerve head astrocytes. Barbara A. Mysona1, 3, J. Zhao2, 3, S. B. Smith1, 3, K. E. Bollinger2, 3. 1Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA; 2Department of Ophthalmology, Medical College of Georgia, Augusta, GA; 3James and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA 4213 — D0232 Retinal astrocytes protect neurons against metabolic stress by inducing the PI3K pathway. Samih Alqawlaq1, 2, I. Livne-Bar3, D. Chan1, 2, J. M. Sivak1, 4. 1Department of vision science, Krembil Research Institute, Toronto, ON, Canada; 2Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada; 3 School of Optometry, University of California Berkeley, Berkeley, CA; 4Laboratory of Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada 4214 — D0233 A novel method to assess astrocyte calcium in rat retina. Hui Li2, L. Wang1, G. Cull1. 1Devers Eye Institute, Portland, OR; 2 Ophthalmology, Shanghai Tenth People’s Hospital, Shanghai, China 4215 — D0234 Glial cells of the optic nerve and Persistent Fetal Vasculature (PFV) disease. Stacey L. Hose1, C. Zhang2, J. S. Zigler1, J. Qian1, D. Sinha1. 1Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, MD; 2Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY Exhibit/Poster Hall D0251-D0307 Tuesday, May 03, 2016 3:45 PM-5:30 PM Multidisciplinary Ophthalmic Imaging Group / Anatomy and Pathology/Oncology 385 Clinical and Other Applications of OCT Moderators: Delia DeBuc and Brandon J. Lujan 4216 — D0251 Ganglion cell loss in early Alzheimer’s disease: evidence in optical coherence tomography. Cristina Castella1, A. Saint-Jean1, M. Balasa2, B. Sanchez1. 1 Ophthalmology, CHU Nantes, Nantes, France; 2 Neurology, Hospital Clinic Barcelona, Barcelona, Spain 4217 — D0252 Investigation of Retinal thickness using OCT in Autism Spectrum Disorder. Julie-Anne Little2, P. M. Anketell2, 1, L. Doyle2, K. Saunders2. 1Belfast Health and Social Care Trust, Belfast, United Kingdom; 2Biomedical Sciences Research Institute, Ulster University, Coleraine, United Kingdom 4218 — D0253 Optic Nerve Head Perfusion and Retinal Structural Measurement by Optical Coherence Tomography in Multiple Sclerosis. Liang Liu1, S. Rebecca2, Y. Jia1, X. Zhang1, O. Tan1, D. Huang1.1Casey Eye Institute, Oregon Health & Science University, Portland, OR; 2Department of Neurology, Portland VA Medical Center, Oregon Health & Science University, Portland, OR *CR 4219 — D0254 Progressive loss of retinal ganglion cells and RNFL in non-optic neuritis eyes of multiple sclerosis patients - a longitudinal study. Elizabeth C. Graham1, 2, Y. You1, 2, M. H. Barnett3, J. Parratt3, C. Yiannikas3, A. Klistorner1, 2. 1 Ophthalmology, Sydney University, Gladesville, NSW, Australia; 2Ophthalmology and Vision Science, Macquarie University, Sydney, NSW, Australia; 3Neurology, Sydney University, Sydney, NSW, Australia 4220 — D0255 Longitudinal Follow-Up of Papilledema by Optical Coherence Tomography Macular Segmentation. Kim Jiramongkolchai1, T. Bhatti1, I. Aboobakar1, C. Mehanna2, M. El-Dairi1. 1 Duke Eye Center, Duke University, Durham, NC; 2 Ophthalmology, American University of Beirut, Beirut, Lebanon 4221 — D0256 Swept-source Optical Coherence Tomography Angiography Features in Behçet’s Uveitis. Salim Ben Yahia1, 2, N. Abroug1, 2, S. Khochtali1, 2, R. Kahloun1, 2, B. Jelliti1, 2, F. Nouira3, M. Khairallah1, 2. 1Department of Ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia; 2Faculty of Medicine, University of Monastir, Monastir, Tunisia; 3Laser Center of Sousse, Sousse, Tunisia The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 282 Tuesday – Posters – 4222 – 4240 4222 — D0257 Inter-method agreement in retinal blood vessels diameter analysis between Dynamic Vessel Analyzer and Optical Coherence Tomography. Maria Vittoria Cicinelli1, L. Benatti1, L. Tomasso1, F. Corvi1, A. Mazzaferro2, A. Carnevali3, I. Zucchiatti1, L. Querques1, F. Bandello1, G. Querques1. 1Ophthalmology, San Raffaele Scientific Institute, Milan, Italy; 2 Ophthalmology, University of Messina, Milan, Italy;3ophthalmology, University of Magna Graecia, Catanzaro, Italy 4223 — D0258 Structure-Function Analysis in Chiasmal Compression Helps Predict Visual Prognosis. Juthamat Witthayaweerasak1, 2, M. Sun1, 3, A. Shariati1, J. Li1, Y. J. Liao1. 1 Ophthalmology, Stanford Medical Center, Stanford, CA; 2Ophthalmology, Prince of Songkla University, Hatyai, Thailand; 3Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan 4225 — D0260 Ganglion Cell Complex Thickness Distributions Measured with 3D OCT1 Maestro in Normal Eyes. Qi Yang, Y. Dong, W. Huang, D. Leung, C. A. Reisman, K. Chan. Topcon Advanced Biomedical Imaging Laboratory, Topcon Medical Systems, Oakland, NJ *CR 4226 — D0261 Diagnostic accuracy of retinal nerve fiber layer, macular ganglion cell complex and optic nerve head measurements using spectral-domain optical coherence tomography. Frédéric Pollet-Villard, C. Chiquet, J. Romanet, F. Aptel. Ophtalmology, Grenoble University Hospital, Grenoble, France 4227 — D0262 In Vivo Assessment Of Optic Nerve Head Pre-Laminar Neural Tissue Thickness In Glaucoma: Diagnostic Performance And Correlation With Conventional Parameters. Bernardo de Padua Soares Bezerra1, F. S S Lopes2, D. Torres Dias2, M. Ushida3, I. Matsubara3, F. Nishimura Kanadani1, S. Dorairaj4, T. Santos Prata2, 3. 1Glaucoma, instituto de Olhos Ciências Médicas, Belo Horizonte, Brazil; 2Universidade Federal de São Paulo, São Paulo, Brazil; 3Hospital Medicina dos Olhos, Osasco, Brazil; 4Mayo Clinic, Jacksonville, FL 4229 — D0264 Comparative Analysis: To assess the level of agreement between PRIMUS (ZEISS India) and CIRRUS (ZEISS Dublin CA) SDOCT Normative Database limits. Krunalkumar Ramanbhai Patel1, G. T C1, S. Natesh2. 1Carin, Carl Zeiss India, Bangalore, India; 2Nethra Eye Hospital, Bangalore, India *CR 4230 — D0265 Ethnic Variation in optic disc and macular structure by Optical Coherence Tomography. Paolo Turchetti1, F. Pacella2, F. Izzo1, C. Fazioli1, C. Mirisola1, S. Altimari1. 1INMPNIHMP, Rome, Italy; 2University Sapienza, Roma, Italy 4231 — D0266 Assessment of eccentric vitreous density in healthy subjects using optical coherence tomography. Robert J. Barry1, 2, H. Ibrahim1, T. Macdonald1, M. Allie6, P. I. Murray1, 6 , P. A. Keane3, T. Aslam4, 5, A. K. Denniston2, 1. 1 Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; 2 Department of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 3Department of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom; 4Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, United Kingdom; 5University of Manchester, Manchester, United Kingdom; 6Department of Ophthalmology, Birmingham & Midland Eye Centre, Birmingham, United Kingdom 4232 — D0267 Quantification of intraretinal hard exudates with Enface Optic Coherence Tomography. Sowmya Srinivas1, M. G. Nittala1, A. H. Hariri1, M. Pfau1, J. Gasperini2, S. R. Sadda1. 1 Ophthalmology, Doheny Eye Institute, University of California, Los Angeles, CA; 2Ophthalmology, South coast retinal center, Long beach, CA *CR 4233 — D0268 Reduced Ganglion cell volumetric assessment by spectral-domain optical coherence tomography in patients with Geographic Atrophy. Hema L. Ramkumar, Q. You, D. G. Bartsch, W. R. Freeman. Ophthalmology, University of California, San Diego, La Jolla, CA 4234 — D0269 Significance of Choroidal Hyper-reflective foci visualised on Enhanced Depth Imaging in Central Serous Chorioretinopathy. Namritha V. Patrao2, D. Menon2, M. Zola2, P. Sanghi1, L. Nicholson2, P. Hykin2, S. Sivaprasad2. 1Institute of Ophthalmology, University College of London, London, United Kingdom; 2NIHR Moorfields Biomedical Research Centre, London, United Kingdom *CR 4235 — D0270 Assessment of vitreous inflammation before and after corticosteroid therapy in patients with uveitic cystoid macular edema using optical coherence tomography. Hussein Ibrahim2, R. J. Barry2, 1, M. Allie3, P. I. Murray2, 1, P. A. Keane4, T. Aslam5, 6, A. K. Denniston1, 2. 1Department of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 2Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom; 3Department of Visual Function, Birmingham and Midland Eye Centre, Birmingham, United Kingdom; 4 Department of Ophthalmology, Moorfields Eye Hospital, London, United Kingdom; 5Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, United Kingdom; 6University of Manchester, Manchester, United Kingdom 4236 — D0271 Comparison of retinal ganglion cell - inner plexiform layer thickness measured by Cirrus and Spectralis optical coherence tomography in eyes with diabetic macular edema. Julia Hafner, S. G. Prager, J. Lammer, K. Kriechbaum, C. Scholda, U. Schmidt-Erfurth. Ophthalmology and Optometry, Medical University Vienna, Austria, Vienna, Austria 4237 — D0272 Retinal thickness irregularities in preclinical diabetic retinopathy. Alan Poon1, 2, T. Wright2, A. Dupuis5, 3, C. A. Westall2, 4. 1Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 2Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, ON, Canada; 3Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; 4 Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; 5Clinical Research Services, The Hospital for Sick Children, Toronto, ON, Canada 4238 — D0273 Type 2 diabetes mellitus patients with white dots in the central fundus and neuroretinal degeneration. Stanley Darma1, R. O. Schlingemann1, P. Kok1, M. D. Abramoff3, F. Holleman2, F. D. Verbraak1, 4. 1Ophthalmology, Academic Medical Center, Amsterdam, Netherlands; 2Internal Medicine, Academic Medical Centre, Amsterdam, Netherlands; 3Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA;4Biomedical Engineering and Physics, Academic Medical Centre, Amsterdam, Netherlands 4239 — D0274 Perifoveal vessels and structural changes visualized in deeper layers of diabetic retinas. Edmund Arthur, J. A. Papay, B. P. Haggerty, C. A. Clark, A. E. Elsner. School of Optometry, Indiana University, Bloomington, IN 4240 — D0275 A Novel Spectral Domain Optical Coherence Tomography (SD-OCT) Classification Scheme for the Differential Diagnosis of Macular Edema of Diabetic and Retinal Veno-Occlusive Origin. Mikel Mikhail, R. Coussa, D. E. Lederer. McGill University, Montreal, QC, Canada f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 283 Tuesday Posters 3:45 pm – 5:30 pm 4224 — D0259 The eye as a window to the brain. Retinal structure is associated with cerebral injury in HIV-infected children. Frank D. Verbraak1, N. Demirkaya1, C. Blokhuis2, S. Cohen2, F. Wit3, 4, M. Caan5, H. Scherpbier2, M. D. Abramoff6, 7, D. Pajkrt2. 1Ophthalmology, Academic Medical Center, Amsterdam, Netherlands; 2 Pediatric Infectious Diseases, Emma Children’s Hospital, Amsterdam, Netherlands; 3Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands; 4Amsterdam Institute for Global Health ans Development, Amsterdam, Netherlands; 5 MRI, Academic Medical Center, Amsterdam, Netherlands; 6Ophthalmology and Visual Science, University of Iowa, Iowa, IA; 7Biomedical Engineering, Iowa Institute for Biomedical Imaging, Iowa, IA 4228 — D0263 Diurnal variation in summary measures and inter-visit test-retest variability of standard automated perimetry and spectral domain optical coherence tomography. John Pearce, T. Maddess. John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia *CR 4241 – 4263 – Tuesday – Posters 4241 — D0276 Preoperative Optical Coherence Tomography Findings in Macular Epiretinal Membrane. Miyu Ichida, Y. Hirano, N. Suzuki, T. Tomiyasu, T. Yasukawa, Y. Ogura. Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 4242 — D0277 Selective Depletion Of Ganglion Cells Layer In Unaffected Fellow Eye Of Patients With Idiopathic Epiretinal Membranes In Controlateral Eye. Andrea M. Coppe, G. Lapucci, G. Ripandelli. GB Foundation Study Ophth IRCCS, Rome, Italy 4243 — D0278 Radial symmetry of the foveal pit curvature assessed with optical coherence tomography. Dean A. VanNasdale, A. Eilerman. Optimedica, Ohio State Univ College of Optometry, Columbus, OH Tuesday Posters 3:45 pm – 5:30 pm 4244 — D0279 Location of foveola relative to optic nerve head in healthy eyes using spectral domain optical coherence tomography (SDOCT). Robert A. Sharpe, D. Williams, R. H. Trivedi, J. Blice. Ophthalmology, Medical University of South Carolina, Charleston, SC 4245 — D0280 Axonal pore paths get closer to the optic nerve center with increased depth through the lamina cribrosa. Zachary M. Dong1, B. Wang1, 2, J. S. Schuman1, 2, K. Lucy1, R. A. Bilonick1, 3, C. D. Lu4, I. A. Sigal1, 2, L. Kagemann1, 2, J. G. Fujimoto4, H. Ishikawa1, 2, G. Wollstein1, 2. 1 UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Ophthalmology and Visual Science Research Center, Pittsburgh, PA; 2 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA; 3Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA; 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 4246 — D0281 Optical Coherence Tomography Minimum Intensity Abnormalities in Hydroxychloroquine Toxicity. Paul F. Stetson1, A. M. Allahdina2, S. Vitale2, C. Cukras2. 1Research and Development, Carl Zeiss Meditec, Dublin, CA; 2 National Eye Institute, Bethesda, MD *CR, f 4247 — D0282 Outer retinal reflectivity on En-face OCT as a new tool to detect early stage hydroxychloroquine maculopathy. Adrien Viotte, G. Bigan, M. Flores, C. Girard, B. Y. Delbosc, M. Saleh. ophtalmology, CHU Besançon, Besançon, France 4248 — D0283 Photoreceptor anisotropy in macular oedema and MacTel : a multiangle OCT study. Alexandre Pedinielli1, M. Laguarrigue2, S. Mrejen2, F. Rossant2, R. Tadayoni1, A. Gaudric1, V. Krivosic1, M. Paques2. 1Ophthalmology, Hôpital Lariboisière, Paris, France; 2Quinze-Vingts Hospital, Paris, France 4249 — D0284 Compartmentalization of intraretinal empty spaces in MacTel by SS OCT. Pascal W. Hasler, C. Gyger, P. Maloca. Eye Clinic, University Hospital Basel, Arlesheim, Switzerland *CR 4250 — D0285 Altered Photoreceptor Bands Surrounding Areas of Loss in MacTel Cause En Face OCT Endpoint Variability. Brandon J. Lujan1, 2, E. Y. Chew3, J. L. Duncan4, B. J. Antony1, 5, V. Makhijani1, 6, A. Roorda1. 1School of Optometry and Vision Science Graduate Program, University of California, Berkeley, Berkeley, CA; 2Ophthalmology, Casey Eye Institute, OHSU, Portland, OR; 3Epidemiology and Clinical Applications, National Eye Institute/ National Institutes of Health, Bethesda, MD; 4 Ophthalmology, University of California, San Francisco, San Francisco, CA; 5Electrical & Computer Engineering, Johns Hopkins University, Baltimore, MD; 6Ophthlalmology, Bronx-Lebanon Hospital, Bronx, NY *CR 4251 — D0286 Ocular Coherence Tomography Used to Support an Investigational New Drug Application for a C3 Complement Inhibitor Targeting Macular Degeneration. Margaret E. Collins1, J. S. Slakter2, R. Munger3, P. Wells1, C. Kolodziej1, P. Deschatelets4, R. Stoll5. 1Ophthalmology, Charles River, Reno, NV; 2NYU Medical School, Great Neck, NY; 3 Animal Ophthalmology, Dallas, TX; 4Potentia Pharmaceuticals, Inc, Crestwood, KY; 5Stoll & Associates, Storrs Mansfield, CT *CR 4252 — D0287 Measurement of macular hole dimensions by OCT shadowgraphy. Saruban Pasu, P. Tanna, J. W. Bainbridge. Moorfields Eye Hopsital, London, United Kingdom 4253 — D0288 En Face Spectral-Domain Optical Coherence Tomography Imaging of Photoreceptor Layer in Repaired Macular Hole. Yonguk Kim, H. Kwak, S. Yu. Ophthalmology, Kyung Hee University Hospital, Seoul, Korea (the Republic of) *CR 4254 — D0289 Ocular Coherence Tomographic Imaging in Patients with Recurrent Full Thickness Macular Holes. Eli Levitt, G. Yu, A. Bassiri, J. G. Arroyo. Eye, Beth Israel Deaconess Medical Center, Coral Gables, FL 4255 — D0290 Comparison of Corneal Topography, Optic Coherence Tomography, Macula Pigment Optic Density of High Myopic Eyes And Emmetropic Eyes in Terms of Visual Acuity, Axial Length, Posterior Segment Signs. Zeliha Yazar, A. Metin Kayhan. Ophthalmology, Ankara Numune Edu & Rsrch Hosp, Ankara, Turkey 4257 — D0292 A New Quantitative Approach in Analyzing Polypoidal Choroidal Vasculopathy In Vivo Using En Face Optical Coherence Tomography. Jonathan Chou1, E. Chan2, J. Simonett3, A. A. Fawzi3. 1Ophthalmology, Massachusetts Eye & Ear Infirmary, Cambridge, MA; 2Ophthalmology, National University Hospital, Singapore, Singapore; 3Ophthalmology, Northwestern University, Chicago, IL 4258 — D0293 Optical Coherence Tomography in the Evaluation of Neovascular Lesions and Serous Pigment Epithelial Detachments in Polypoidal Choroidal Vasculopathy. Eric Weinlander, A. Domalpally, E. Corkery, B. A. Blodi. Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine, Madison, WI 4259 — D0294 Correlation of Indocyanine Green Angiography and Optical Coherence Tomography in Polypoidal Choroidal Vasculopathy. Tarek Alasil1, N. M. sanz2, P. A. Keane2, P. Coady1, A. Tufail2, R. A. Adelman1. 1 Ophthalmology and Visual Sciences, Yale University, New Haven, CT; 2Ophthalmology and Visual Sciences, Moorfields Eye Hospital, London, United Kingdom 4260 — D0295 Optical Density of Subretinal Fluid in Proliferative Vitreoretinopathy. Rayan Alshareef, V. Sun, A. Dan, M. Kapusta. School of Medicine, McGill University, Montreal, QC, Canada 4261 — D0296 Multicolor and Optical Coherence Tomography Appraisal of Deep Retinal Capillary Ischemia. Rosa Dolz-Marco2, 1, L. Monje-Fernandez1, 3, M. Andreu-Fenoll1, 2, N. Garcia-Marin1, R. Gallego-Pinazo1, 4. 1Macula Unit, University and Polytechnic Hospital La Fe, Valencia, Spain; 2Institute for Health Research, University and Polytechnic Hospital La Fe, Spain, Valencia, Spain; 3University Hospital Complex of León, Leon, Spain; 4Retics Oftared (RD12/0034); Prevention, Early Detection And Treatment Of The Prevalent Degenerative And Chronic Ocular Pathology, Institute of Health Carlos III, Madrid, Spain *CR 4262 — D0297 Swept Source OCT Imaging of Retinal Colobomas. Kelly Rue, A. Y. Kim, H. A. Aziz, L. C. Olmos. Ophthalmology, USC, Los Angeles, CA *CR 4263 — D0298 Spectral Domain Optical Coherence Tomography Imaging of Subretinal Bands Associated with Chronic Retinal Detachment. Nikisha Kothari, A. Kuriyan, H. W. Flynn. Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 4256 — D0291 Spectral-Domain Optical Coherence Tomography Findings in Peters’Anomaly infants. Jiaxu Hong1, X. Sun1, R. Dana2, J. Xu1. 1Ophthalmology, Eye & Ear, Nose, Throat Hospital, Shanghai, China; 2Harvard Medical School, Boston, MA The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 284 Tuesday – Posters – 4264 – 4272 4264 — D0299 Limitations of Retinal Thickness Analysis in Cross-Sectional Data. Daniel Rock3, L. Marahrens3, R. Kern1, T. Ziemssen1, A. Fritsche2, F. Ziemssen3. 1Department of Neurology, University Hospital Carl Gustav Carus at the Dresden University of Technology, Dresden, Germany, Dresden, Germany; 2 Department of Internal Medicine, Eberhard Karls University, Tuebingen, Germany, Tuebingen, Germany; 3Center for Ophthalmology, Eberhard Karls University, Tuebingen, Germany, Tuebingen, Germany *CR 4265 — D0300 3D diagnostic imaging of retinoblastoma with a novel optical coherence tomography clinical system. Oleg Nadiarnykh1, A. Moll2, J. F. De Boer1. 1Physics, Vrije University, Amsterdam, Netherlands; 2Ophthalmology, VU University Medical Center, Amsterdam, Netherlands *CR 4266 — D0301 Diagnosing senile Retinoschisis, SD-OCT versus ultrasound echography examination. Arne Bringewatt, S. Burzer, N. Feucht, C. P. lohmann, M. M. Maier. Department of Ophthalmology, Klinikum rechts der Isar, Munich, Germany 4271 — D0306 The impact of swept-source optical coherence tomography (SS-OCT) in the management of scleral inflammation. Maite Sainz De La Maza, M. Hereu, M. Hernandez, M. Mesquida, V. Llorenç, A. Sala-Puigdollers, J. Matas, B. Molins, A. Adan Civera, J. ZarranzVentura. Clinic Institute of Ophthalmology, Hospital Clinic of Barcelona, Barcelona, Spain 4272 — D0307 Scleral toricity measurement with 1050 nm Swept-Source Optical Coherence Tomography. Ahmed M. Hagag1, 2, M. Tang1, Y. Li1, D. Huang1. 1Department of Ophthalmology, Oregon Health and Science University, Portland, OR; 2Mansoura Faculty of Medicine, Mansoura, Egypt *CR Tuesday Posters 3:45 pm – 5:30 pm 4267 — D0302 Spectral domain optical coherence tomography measurement of the retinal pigment epithelium and Bruch’s membrane complex thickness, and its associations in a large population cohort, UK Biobank. Zaynah A. Muthy2, 1, F. Ko2, 1, P. J. Foster2, 1, N. G. Strouthidis2, 1, Q. Yang5, C. A. Reisman5, U. Chakravarthy3, A. J. Lotery4, A. Tufail1, 2, P. A. Keane1, 2, P. J. Patel2, 1. 1UCL Institute Of Ophthalmology, London, United Kingdom; 2NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom; 3 Optometry & Vision Science, Queens University of Belfast, Belfast, United Kingdom;4Ophthalmology, Southampton General Hospital, Hampshire, United Kingdom; 5Topcon Advanced Biomedical Imaging Laboratory, Oakland, NJ *CR 4270 — D0305 SD-OCT Assessment of Retinal Structure After Subretinal Implantation of a Substrate-Adherent Monolayer of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium. Ana Martynova5, A. H. Kashani5, R. A. Brant1, M. Koss2, D. Zhu4, D. R. Hinton4, D. O. Clegg3, M. S. Humayun5. 1Department of Ophthalmology, UNIFESP Hospital Sao Paulo, Sao Paulo, Brazil; 2Ophthalmology, University of Heidelberg, Heidelberg, Germany; 3Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA; 4 Pathology, University of Southern California, Los Angeles, CA; 5Ophthalmology, University of Southern California, Los Angeles, CA *CR 4268 — D0303 Visualization of the Macula in Gas-filled Eyes using Swept-Source Optical Coherence Tomography: Comparison with Spectral-Domain Optical Coherence Tomography. Byung Ro Lee, S. Ahn, S. Park. Ophthalmology, Hanyang Univ Hosp, Seoul 4269 — D0304 Monitoring X-Linked Retinoschisis (XLRS) by Optical Coherence Tomography (OCT). Emily A. Swanson, R. J. Munro, L. Ambrosio, T. S. Bowe, A. Moskowitz, R. M. Hansen, J. D. Akula, A. B. Fulton. Ophthalmology, Boston Children’s Hospital, Boston, MA f Refer to the Program Number in the Clinical Trial (CT) Registration Index. *CR Refer to the Program Number in the Commercial Relationships (CR) Index for Disclosures. 285 4273a – 4273h – Tuesday – ARVO/Champalimaud Lecture Room 6B Tuesday, May 03, 2016 5:45 PM-7:00 PM 386 ARVO/Champalimaud Award Lecture - Strengthening eye care services across Africa: The KCCO/ Seva Canada/Seva Foundation Project The António Champalimaud Vision Award, established by the Champalimaud Foundation in 2006, honors outstanding contributions to the preservation and understanding of sight. Vision loss remains a significant problem in subSaharan Africa. In the last 15 years there has been considerable work that provides eye care providers with some of the evidence necessary to inform practices, programmes, and policies. First, the presentation will cover our growing understanding of the epidemiology of vision loss and major causes as well as the major challenges faced. Second, based upon work throughout Africa (and other places) the factors that are associated with improved eye care service delivery will be reviewed. Third, new socio-entrepreneurial models and their impact will be reviewed. Fourth, the evidence for action related to human resources for eye health will be covered. The final section of the talk will cover continuing challenges and the operational research needs. Tuesday, Lecture 5:45 pm – 7:00 pm 4273a — 5:45 Panelist discussion. Paul Courtright. Kilimanjaro Centre for Community Ophthalmology 4273b — 5:45 Panelist discussion. Susan Lewallen. Kilimanjaro Centre for Community Ophthalmology 4273c — 6:00 Panelist discussion. Heidi Chase. Seva Foundation 4273d — 6:15 Panelist discussion. Suzanne Gilbert. Seva Foundation 4273e — 6:30 Panelist discussion. Penny Lyons. Seva Canada 4273f — 6:45 Panelist discussion. Ken Bassett. Seva Canada 4273g — 6:45 Panelist discussion. Gerald Msukwa. Visiting Ophthalmologist 4273h — 6:45 Panelist discussion. Levi Kendeke. Visiting Ophthalmologist The Commercial Relationships (CR) Index for Disclosures and the Clinical Trial (CT) Registration Index are at arvo.org/amindices. 286
