Download Course Study Guide

Course Study Guide
SECOND YEAR
FACULTY OF MEDICINE PADJADJARAN UNIVERSITY
ACADEMIC YEAR 2014-2015
Course Study Guide
DermatoMusculoSkeletal System
SECOND YEAR
FACULTY OF MEDICINE PADJADJARAN UNIVERSITY
ACADEMIC YEAR 2014-2015
1. Rational / Synopsis
In this system the students will learn the basic science and clinical aspect in Skin, Muscular and Skeletal diseases.
2. Intended Competency
Fulfilled SKDI 1-4
3. Number of SCU and length of week
8 SCU in 8 weeks
4. General learning outcome
After completing this system the students should be able to review the embryology, anatomy, physiology, biochemistry that related to the Dermatomuscularskeletal
system and the epidemiology, pathogenesis, pathophysiology, diagnosis and management of diseases in the Dermatomuscularskeletal system.
1
5. Specific Learning Objective
No
Department
Specific Learning Objective
Delivery method
Assessment
methods
Reference
Relation
to the
rule as a
doctors
1.
Anatomy
1.1 Integument system & bone
Lab act : Structure and function of
skin appendages
1.1.1. Explain the anatomy of skin
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley,
Tutorial :
1.2 The scalp and face
1.2.1. Describe the layers of the scalp
Lab Act : Structure and function of
skin appendages
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
1.2.2. Describe the blood supply, innervation and
lymphatic drainage of the scalp
Lab act : Structure and function of
skin appendages
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
1.2.3. Relate the anatomical knowledge to
common clinical conditions involving the
scalp e.g. due to trauma or infections
Tutorial :
MDE, OSCE
Clinically Oriented Anatomy
: Moore &Dalley,
1.2.4. Describe briefly the facial muscles
Tutorial :
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
MDE
Clinically Oriented Anatomy
Lab Act : Structure and function of
skin appendages
1.2.5. Illustrate territories of the face supplied by
the divisions of the trigeminal nerve
Tutorial :
Lab Act : Structure and function of
skin appendages
1.2.6. Describe the extracranial division of the
facial nerve
Tutorial :
1.2.7. Describe the blood supply and lymphatic
drainage of the face
Tutorial :
: Moore &Dalley,
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley,
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
MDE
Clinically Oriented Anatomy
: Moore &Dalley
MDE
Clinically Oriented Anatomy
: Moore &Dalley
MDE
Clinically Oriented Anatomy
: Moore &Dalley
MDE
Clinically Oriented Anatomy
Lab Act : Structure and function of
skin appendages
Lab Act : Fascia of the neck,
vascularization head&neck
1.3. The neck
1.3.1. Illustrate the subdivisions of the fasciae of
the neck
Tutorial :
1.3.2. Describe the boundaries of the anterior
and posterior triangles of the neck
Tutorial :
1.3.3. State the contents of the anterior and
posterior triangles of the neck
Tutorial :
1.3.4. Describe the location of the lymph nodes
in the neck and their areas of drainage
Tutorial :
Lab Act : Fascia of the neck,
vascularization head&neck
Lab Act : Fascia of the neck,
vascularization head&neck
Lab Act : Fascia of the neck,
vascularization head&neck
Lab Act : Fascia of the neck,
vascularization head&neck
1.4. The oral, maxillofacial and neck region
1. 4.1 Explain the oral (include teeth), maxillofacial
Lab act :Basic anatomy of
maxillofacial, orbita, skull base &
and neck region
cranial fossa
: Moore &Dalley,
Tutor :
1.5. Muscular tissue and muscular system
1.5.1. Overview of muscular tissue
Tutorial :
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley,
MDE
Clinically Oriented Anatomy
: Moore &Dalley
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley,
MDE, SOCA
Clinically Oriented Anatomy
: Moore &Dalley,
Lab act : Basic anatomy and
kinesiology of trunk, pelvis & hip
joint
1.5.2. Naming of skeletal muscle
Tutorial :
Lab act : Basic anatomy and
kinesiology of trunk, pelvis & hip
joint
1.5.3. Relationship of structure (upper limb and
lower limb) which close to the bone
pertaining certain lession such as trauma
and injury
Tutorial :
Lab act : Basic anatomy and
kinesiology of trunk, pelvis & hip
joint
1.6. Spine
1.6.1. Explain anatomy of spine (parts, joint,
physiological curve, special structure and
muscle)
1.6.2 Explain the Scapular anastomosis
Tutorial :
Lab act : Basic anatomy and
kinesiology of trunk, pelvis & hip
joint
1.7 Musculoskeletal System
1.7.1 Explain the Anatomy of the bone on the upper
limb and lower limb
Tutorial :
Lab act : Skeleton of the body (
axial & appendicular)
1.7.2 Explain the vascularization, innervations of
upper arm : brachial pleksus
1.7.3 Explain about Relationship of structure
(upper limb and lower limb) which close to
the bone pertaining certain lession such as
trauma and injury  brachial nerve injury
1.7.4 Explain the anatomy of lower limb :
muscular system, vascularization &
innervation
17.5. Explain about Foot, muscle, bonen nerve
and arches of the foot
Lab Act : Axillary space ( wall &
content), muscular
system of the upper arm,
vascularization and
innervations
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
MDE
Clinically Oriented Anatomy
: Moore &Dalley,
Tutorial :
Lab Act : popliteal space,
musculoskeletal system,
vascularization and innervations of
the lower limb incl. Foot (
lumbosacral pleksus ,)
1.8 Bone and Joint
2
Cell Biology
SOCA, MDE
Explain the anatomy of the knee Joint including
bone formation (X-ray), muscles group and
kinesiology.
Tutorial : "
2.1 Embryology of Integument system & bone
Tutorial :
Clinically Oriented Anatomy
: Moore &Dalley,
SOCA, MDE
Moore and Persaud. The
developing human. 7th ed.
2003,p.485-491.
SOCA, MDE
Luiz carlos Junquerra. Basic
Histology, 11th ed. 2003. P
360-370.
Lab Act : Structure and function of
skin appendages
2.2 Histology of the skin & bone
Tutorial :
Lab Act : Structure and function of
skin appendages
2.3 The oral, maxillofacial and neck region
The embryology and histology of the oral
(include teeth), maxillofacial and neck region.
Tutorial :
SOCA, MDE
Lab Act : Fascia of the neck,
vascularization head&neck
Moore and Persaud. The
developing human. 7th ed.
2003,p.485-491
Luiz carlos Junquerra. Basic
Histology, 11th ed. 2003. P
360-370.
2.4 Muscular tissue and muscular system
• Skeletal muscle tissue
 Cardiac muscle tissue
 Smooth muscle tissue
 Development of muscle
2.5 Spine
Explain embryogenic development process of
bodyform
2.6 Musculoskeletal System:
 Explain Embryology and histology of
bone and cartilage
3
Physiology
3.1 The Skin Function
 Explain the The skin as an organ
protection, thermoregulator
3.2 The oral, maxillofacial and neck:
 Explain The physiology of the oral
Tutorial :
SOCA, MDE
Lab act : Basic anatomy and
kinesiology of trunk, pelvis & hip
joint
Tutorial :
Luiz carlos Junquerra. Basic
Histology, 11th ed. 2003. P
360-370.
MDE, SOCA
Moore and Persaud. Human
development
MDE
Lab Act : Embryology & Histology of
bone and cartilage ( include teeth )
Tutorial :
Tutorial :
Moore and Persaud. The
developing human. 7th ed.
2003,p. p.485-491
1.
Junqueira. Basic
histology
2.
Moore and Persaud.
Human development
MDE, SOCA
Guyton AC. Textbook of
medical physiology. WB
Saunders Co. London, 1991.
SOOCA/MDE
Guyton AC. Textbook of
medical physiology. WB
(include teeth), maxillofacial and neck
region.
 Explain the Physiology of mastication,
swallowing, and voice formation.
3.3. The Muscular tissue and muscular system
 Explain Contraction and relaxation of
skeletal muscle fibers
 Explain Muscle metabolism
 Explain Control of muscle tension
 Explain Types of skeletal muscle fibers
 Explain Exercise and skeletal muscle
tissue
 Explain Regeneration of muscular tissue
 Explain Aging of muscular tissue
 Explain Contribution of muscular system
to our body movement systems
4.
Plastic
Surgery
4.1 The Skin problem
1. Explain related to degree / depth of burn.
2. Explain etiology of burn.
3. Explain pathophysiology of burn.
4. Explain Total Body Surface area (TBSA) and
estimate burn extent.
5. Explain classification of burn and criteria of
hospitalization.
6. Explain complication of burn.
7. Explain management of burn patient:




resuscitation
position
surgical management
rehabilitation
Saunders Co. London, 1991.
Tutorial :
SOOCA/MDE
Guyton AC. Textbook of
medical physiology. WB
Saunders Co. London, 1991.
Tutorial :
Mini Lecture:
Current
Issues
Management
on
Burn
1.
Schwartz SI. Principles
of Surgery. Sixth
Edition..Mc Graw Hill
Inc. New York, 1994.
Page 225 – 278.
2.
Settle JAD. Principles
and practice of burns
Management. Churchill
Livingstone. New York,
1996
SOOCA/MDE
Overview of skin disorders related
to the structure:

Impetigo, folliculitis, carbunkel

Fat layer: cellulitis

Muscle : pyomyositis
5
Microbiology
5.1 Microbiology of The Skin
 Overview of Skin infection related
structure and its causative agent, incl :
Impetigo, folliculitis, Carbunkel
6.1 Skin Diseases
Mini Lecture :
Microbiology of the Skin
SOOCA, MDE
TUTORIAL :
MDE
LAB. ACTIVITY : Microbiology spore
forming bacteria aero-anaerobfungi
Mini Lecture :
6
Dentistry
6.1 Infection disorders of Oral, Maxillofacial and
Neck
The pathogenesis of tissue inflammatory
of the mouth due to infection of
dental origin.
Infection due to Clostridium tetani
infection
The microbiology of the oral cavity.
The etiology, epidemiology,
characteristics and route of infection
in the oral, maxillofacial and neck
region.
The predisposition factors of a
progressive acute cellulities (Angina
Von Ludwig) due to dental origin.
The infection management of dental
origin

Parasite infection: Scabies

Bacterial infection: Leprae
Tutorial
MDE
Pharmacology of drug of choice for
causative organism.
Oral hygiene.
Prognosis
Complication.
7.
Dermatology
7.1 Dermatitis
 The etiology of exfoliative dermatitis
 The complication of exfoliative dermatitis
 The principle management of exfoliative
dermatitis
Mini Lecture :
1.
Overview of Dermatological
Emergencie
2.
Dermatotherapy
MDE
Tutorial:
8.
Pathology
Anatomy
8.1 Pathology of the skin
Pathology of the skin tumor and pathology of skin
adnexa and skin healing
Lab Activity:
MDE
Week II
Mini Lecture:
 Overview of skin tumors
 Molecular Basis of Skin Tumor (PA)
9
Orthopaedic
9.1 Explain the Spine Problem
 define HNP is degenerative disorder
 Explain etiology, histopathology, and
pathofisiology of HNP
 analyze anamnesis, pathogenesis and
physical diagnosis of HNP
 Explain electro-diagnostic test &
neuroimaging test
Tutorial:
Skill Lab;
Orthopedic Physical Examination
MDE,SOOCA,
OSCE
Freedberg IM, Katz IS, Wolf
K, Goldsmith LA, Frank AK.
Fitzpatrick`s dermatology in
th
general medicine. 6 ed.
2003.


Explain the management of HNP
Explain complication of HNP
9.2 Trauma of Musculoskeletal System.
 Explain Complication of bone fracture
and its healing (avascular necrosis).
 Explain General principles of trauma
(emergency priority B1- B6, and ATLS)
 Explain Principles of bone fracture
management.
 Explain Classification of fractures on
extremity and skull.
 Explain Normal bone healing of fractures,
 Explain Abnormal healing of fractures,
 Explain Clinical and radiographic features
of extremity and skull
 Explain The general principles of fracture
management of head injury.
 Explain Trauma management according
to ATLS (Advanced Trauma Life Support)
standard
 Explain Hand related abnormality: Carpal
Tunnel Syndrome, Tenosinovitis,
Ganglion
 Explain Nerve lessions injury: sciatic
nerve, abduction injury
Tutorial:
MDE,SOOCA
Skill Lab;
Splinting
Traction
and
Mini Lecture:
ATLS
Bandaging,
Skin
Salter RB. Textbook of
Disorders
of
the
Musculoskeletal System.
Apley’s
System of
Orthopaedics Fractures.
9.3 Degenerative Disorders of Bone and Joint
 Explain the pathology of knee
osteoarthritis
 Explain the management of knee
osteoarthritis related to the basic
science
 Explain of degenerative disorders of bone
and joint
 Explain etiology, pathophyisiology and
clinical features of degenerative
disorders of bone and joint
 Analyze anamnesis and physical
diagnostic of degenerative disorders of
bone and joint
 Explain laboratory test for degenerative
disorders of bone and joint
 Summarize diagnosis and differential
diagnosis of degenerative disorders of
bone and joint
 Explain drugs of degenerative disorders
of bone and joint
 Explain the management of degenerative
disorders of bone and joint
SOOCA, MDE
Tutorial:
1.
Salter RB. Textbook of
Disorders of the
Musculoskeletal
System.
2.
Apley’s System of
Orthopaedics Fractures
1.
Salter RB. Textbook of
Disorders of the
Musculoskeletal
System.
Mini Lecture :
Diagnostic
Approach
and
Principles of Management in
Dislocation Cases
Clinical Aspects
Abnormality
TUTORIAL :
9.4 Fracture and Joint Injury (Upper extremity)
 Explain classification of fracture and
dislocation
 Describe the normal healing of fracture
and dislocation
 Describe the abnormal healing of fracture
and dislocation
of
Spine
SOOCA, MDE
2.
Apley’s System of
Orthopaedics Fractures
1.
 Explain complication of fracture and
dislocation
 Summarize clinical and radiographic
features of fracture and dislocation
 Explain the general treatment principles
of fracture and dislocation
Course Study Guide
Endocrine and Metabolism System
SECOND YEAR TWINNING PROGRAMME
FACULTY OF MEDICINE PADJADJARAN UNIVERSITY
ACADEMIC YEAR 2014 – 2015
1. Rational / Synopsis
In this system the students will learn the basic science and clinical aspect in endocrine and metabolism diseases.
2. Intended Competency
Fulfilled SKDI 1-4
3. Number of SCU and length of week
7 SCU in 6 weeks
4. General learning outcome
After completing this system the students should be able to review the embryology, anatomy, physiology, biochemistry that related to the endocrine and metabolism
system and the epidemiology, pathogenesis, pathophysiology, diagnosis and management of diseases in the endocrine and metabolism system.
14
5. Specific Learning Objectives
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Anatomy
Specific Learning Objectives
Mini
Lecture
Assessment
Method
Reference
Tutorial
Lab
Activity
Evaluate macroanatomy, topography and
vascularisation
of
hypophysis
and
hypothalamus
√
√
MDE, SOCA
6
Analyze macro anatomy, topography and
vascularisation of thyroid gland
√
√
MDE, SOCA
6
Apply macro anatomy, topography and
vascularisation the concept of parathyroid
gland
√
√
MDE, SOCA
6
Analyze macro anatomy, topography and
vascularisation the concept of adrenal gland
√
√
MDE, SOCA
6
Analyze macro anatomy, topography and
vascularisation the concept of pancreas
gland
√
√
MDE, SOCA
6
15
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Biochemistry
Specific Learning Objectives
Mini
Lecture
Tutorial
Lab
Activity
Assessment
Method
Reference
Evaluate action of hormone based on its
structure (lipid, protein, amino acid)
√
MDE, SOCA
2
Analyze the structure, synthesis
secretation of thyroid hormone
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
Apply the mechanism of action (receptor &
2nd messenger), & regulation (HPO axis) of
parathyroid hormone
√
MDE, SOCA
1.2
Analyze
the
structure,
synthesis
&secretation of Adrenal hormone
√
MDE, SOCA
1.2
Analyze the mechanism of action (receptor &
2nd messenger), & regulation (HPO axis) of
Adrenal hormone
√
MDE, SOCA
1.2
&
Analyze the mechanism of action (receptor &
2nd messenger), & regulation (HPO axis) of
thyroid hormone
Explain the structure, synthesis &secretation
of parathyroid hormone
16
Analyze structure, synthesis, secretion, of
insulin & glucagon
√
MDE, SOCA
1.2
Analyze receptor, mechanism of action &
regulation (HPO axis) of pancreatic hormone
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
Understand the genetic background of DM
Apply the metabolism of calcium, phosphate,
&vitamine D
Explain the factors contribute to calcium &
phosphate metabolism
Analyze the metabolism of lipid, lipoprotein,
lipid transport
Analyze the metabolism of keton bodies
Analyze the metabolism of protein and
degradation products such as ammonia
Analyze interrelational metabolism
carbohidrate, lipid and protein
of
Analyze the carbohydrate metabolism and
its relation to lipid and protein metabolism in
various cells (liver, muscle, lipocyte)
Analyze of Amino acid metabolisms
Analyze
Glucose-6-Phosphate
dehydrogenase (G6PD) and the disturbance
in its metabolism pathways
√
√
√
17
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Explain the origin (embryology)
Hypothalamus and Hypophysis
Mini
Lecture
of
Evaluate histological parts and cell type of
Hypophysis,
hypothalamo-hypophyseal
system
Cell Biology
Analyze the embryology of thyroid gland
Analyze the embryology of the parathyroid
gland
Explain the embryology of Adrenal Gland
Analyze histological parts and cell type of
thyroid gland
Explain the embryology of Pancreas Gland
Analyze histological parts and cell type of
Adrenal Gland (glomerulosa, fasiculata,
reticularis)
Assessment
Method
Reference
Tutorial
Lab
Activity
√
√
MDE, SOCA
5
√
√
MDE, SOCA
4
√
MDE, SOCA
5
√
MDE, SOCA
5
√
MDE, SOCA
5
MDE, SOCA
4
MDE, SOCA
5
MDE, SOCA
4
√
√
√
√
√
18
Explain histological parts and cell type of
Pancreas Gland
√
√
MDE, SOCA
4
Assessment
Method
Reference
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Internal
Medicine
Specific Learning Objectives
Mini
Lecture
Tutorial
√
√
MDE, SOCA
7
√
MDE, SOCA
7
Explain the pathophysiology& pathogenesis
of Grave's Disease
√
MDE, SOCA
7
Explain the patophysiology& pathogenesis of
hypoparathyroidism and hypocalcemia
√
MDE, SOCA
7
Explain the patophysiology& pathogenesis of
hypoparathyroidism and hypocalcemia
√
MDE, SOCA
7
Evaluate general concept of endocrine
glands and hormones, specific on concept of
hormonal disorder (hypo &hyperfunction)
Explain disorders of thyroid hormone
(difference between hypo & hyperthyroid)
Lab
Activity
19
Explain the general concept of endocrine
system/hormone disorder & disorders of
adrenocortical insufficiency (primary &
secondary)
√
MDE, SOCA
7
Explain the patophysiology& pathogenesis
of Cushing's Syndrome
√
MDE, SOCA
7
√
MDE, SOCA
7
√
MDE, SOCA
7
√
MDE, SOCA
7
√
MDE, SOCA
7
√
MDE, SOCA
7
Explain the problem of metabolic syndrome
√
Analyze the patophysiology& pathogenesis
of Type 2 DM, including its complication
Explain the clinical aspects of diabetes in
pregnancy
Analyze
the
non
pharmacological
management of DM
Explain
the
pathophysiology
management of DKA
and
√
20
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Mini
Lecture
Understand the physiology of normal growth
and puberty
Explain factors influence growth and puberty
Explain the regulation of growth hormone
and sex steroid hormone secretion (FHS,
LH)
Pediatrics
Describe disorders of growth and puberty
Explain Congenital Hypothyroidism in
relation with Human Development Index
Explain congenital metabolism disorders eq.
galactosemia, phenylketonuria.
Analyze the definition, pathogenesis, and
pathophysiology of Type 1 DM
√
Assessment
Method
Reference
√
MDE, SOCA
1.8
√
MDE, SOCA
1.8
√
MDE, SOCA
1.8
√
MDE, SOCA
1.8
√
MDE, SOCA
1.8
MDE
1.8
MDE, SOCA
1.8
Tutorial
√
√
Lab
Activity
21
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Assessment
Method
Reference
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
Analysis
regulation
of
hormone
(hypothalamus, pituitary, organ axis)
√
MDE, SOCA
1.2
Analyze the functions of growth hormone
(GH) and its physiological actions
√
MDE, SOCA
1.2
Explain the physiological changes due to
excess of GH (example: Acromegaly) and
deficiency of GH
√
MDE, SOCA
1.2
Specific Learning Objectives
Evaluate general concept of hormone and
endocrine glands, specific on embryology of
the glands, autocrine, paracrine, endocrine &
exocrine concepts
Physiology
Analyze the physiological
hypothalamus hormone
effect
of
Analyze the physiological
hypophysis hormone
effect
of
Mini
Lecture
Tutorial
√
Lab
Activity
22
Analyze mechanism effect of the thyroid
hormone
√
MDE, SOCA
1.2
Explain the physiology of the parathyroid
hormone
√
MDE, SOCA
1.2
Analyze the physiology effect of adrenal
hormone
√
MDE, SOCA
1.2
Apply the function of calcium, phosphate,
&vitamine D
√
MDE, SOCA
1.2
Explain the physiological effect of
hypocalcemia and hypercalcemia
Analyze the physiological effect of
pancreatic hormone (insulin & glucagon)
√
MDE, SOCA
1.2
√
MDE, SOCA
1.2
23
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Assessment
Method
Reference
MDE, SOCA
3
√
MDE, SOCA
3
√
MDE, SOCA
3
MDE, SOCA
3
MDE, SOCA
3
Tutorial
Lab
Activity
Explain how hormonal substitution could
overcome the problems
√
√
Analyze the pharmacological aspects of
propylthiouracil and other antithyroid agents
Analyze the pharmacological properties of
Pharmacology steroid hormone
Analyze pharmacological properties of the
antidiabetic drugs, including oral &
parenteral drugs
Apply the pharmacological aspects of
Calcium, Phosphate, & vitamine D
Mini
Lecture
√
√
√
24
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Assessment
Method
Reference
MDE, SOCA
17
√
MDE
17
√
MDE
17
MDE, SOCA
17
Mini
Lecture
Explain the examination the thyroid function
(TSH, TRH, T3, T4, fT4, rT4)
Explain laboratory test related to endocrine
& metabolism disorder
Clinical
Pathology
Explain the specimen collection &
preparation related to endocrine &
metabolism disorder
Practice to identify metabolism disorder:
Glucose in blood and urine, Keton bodies in
urine, Blood Glucose Home Monitoring and
Blood Gas Analysis in Metabolic Acidosis
State
Tutorial
Lab
Activity
√
√
√
25
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Mini
Lecture
Explain the histopathologic disorder of the
thyroid glands
Explain
the
pathogenesis
and
histopathologic changes of endocrine
neoplasia(MEN 1, parathyroid tumor,
gulonoma, insulinoma, pineal gland)
Pathology
Anatomy
Apply the pathogenesis and histopathologic
changes of pituitary diseases: pituitary
adenoma and hyperpituitarism (akromegali,
gigantisme), hypopituitarism, posterior
pituitary syndromes (diabetes insipidus) and
hypothalamic suprasellar tumors (diabetes
insipidus).
List of microscopic feature of pituitary
adenoma, craniopharyngioma.
Tutorial
Lab
Activity
√
√
√
√
√
Assessment
Method
Reference
MDE, SOCA
10
MDE
10
MDE, SOCA
10
MDE
10
26
Apply the pathogenesis and histopathologic
changes
of
thyroid
diseases:
hyperthyroidism, hypothyroidism, thyroiditis,
diffuse and multinodular goiters, neoplasm of
thyroid and congenital anomalies.
√
List of microscopic feature of Hashimoto
thyroiditis, Graves disease, adenomatous
goiter, follicular adenoma, follicular
carcinoma,papillary carcinoma of thyroid and
thyroglossal cyst.
√
MDE, SOCA
10
MDE
10
Apply the pathogenesis of parathyroid
diseases: hyperparathyroid (primary and
secondary
hyperparathyroidism),hypoparathyroid and
pseudo hypoparathyroidism.
√
MDE, SOCA
10
Explain the pathogenesis of pancreas
diseases: diabetes mellitus (diagnosis,
klasifikasi,glucose homeostasis), type 1
diabetes mellitus (genetic susceptibility,
environmental factor, mechanism of B-cell
destruction), type 2 diabetes mellitus (
insulin
resistance,B-cell
dysfunction),
monogenic forms of diabetes, complication
of diabetes mellitus, morphology of diabetes
and its late complications, clinical feature of
diabetes and pancreatic endocrine
neoplasm.
√
MDE, SOCA
10
27
Explain
the
pathogenesis
and
histopathologic changes of adrenal
diseases: adrenocortical hyperfunction
(Cushing
syndrome,
primary
hyperaldosteronism,adrenogenital
syndrome), adrenocortical insufficiency
(primary acute adrenocortical insufficiency,
primary chronic adrenocortical insufficiency,
secondary adrenocortical insufficiency),
adrenocortical neoplasm and adrenal
medulla lesion (pheochromocytoma).
√
List microscopic feature of adrenocortical
adenoma and pheocromocytoma.
√
MDE, SOCA
10
MDE
10
Assessment
Method
Reference
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
Nuclear
Medicine
Indicate the role of nuclear medicine in
hormonal problem
Mini
Lecture
√
Tutorial
Lab
Activity
MDE
28
Analyze the nutritional aspect of diabetes
mellitus (Diabetic Medical Nutrition)
Nutrition
Radiology
√
Apply dietary considerations as nonpharmacological interventions for patients
with type 2 Diabetes
Describe radiology structure of endocrine
gland
√
MDE, SOCA
9
√
MDE, SOCA
9
MDE
11
Assessment
Method
Reference
√
SOCA
12
√
SOCA
12
√
CSG
Second Year Programme
Endocrine and Metabolism
Year Academic :
System:
Delivery Method
Department
Specific Learning Objectives
BHP
Evaluate the duty of a doctor to explain the
risk honestly
Apply the concept of the difference between
the occurrence of foreseen risk, unforeseen
risk and malpractice case
Mini
Lecture
Tutorial
Lab
Activity
29
Evaluate doctor’s duty to be able to
communicate properly with patients from
various social and educational background
√
SOCA
12
Evaluate relationship between colleagues in
multidisciplinary team approach in patient
management
√
SOCA
12
Evaluate the responsibility of medical
professionals to ensure the patient received
proper therapy
√
SOCA
12
√
SOCA
Evaluate the community research and public
CRP & PHOP health aspect in the case
30
6. Specific Learning Objectives of Clinical Skills
CSG
Year Academic :
System:
Second Year Programme
Endocrine and Metabolism
Learning objective
Delivery
Method
Assessment
Method
Reference
The students will be able to performe
measurements of weight, height and
body proportion in children
Skills
Laboratory
OSCE
13
The students will be able to perform
History Taking in Thyroid
history taking related to thyroid
Disease
disease
Skills
Laboratory
OSCE
14
The students will be able to perform
physical examination related to thyroid
disease
Skills
Laboratory
OSCE
14
The student will be able to write
prescription order properly
Skills
Laboratory
OSCE
3
The students will be able to perform
Diabetic Foot Care in
diabetic foot care to support
Diabetes Mellitus patients
management in diabetic patients.
Skills
Laboratory
OSCE
16
The students will be able to perform
Administering intramuscular,
intramuscular, subcutaneous and
subcutaneous
and
intracutaneous injection in a good
intracutaneous injection
manner
Skills
Laboratory
OSCE
15
Topic
Assessment of
Anthropometry
Growth
Physical Examination
Thyroid Disease
Drug Prescription
in
31
7. References
1.Guyton and Hall, 2011, Textbook of Medical Physiology, 12th Edition, Elsevier.
2. Harper's Illustrated Biochemistry,29th edition, Lange & McGraw Hill.
3. Katzung, Masters and Trevor, Basic and Clinical Pharmacology,12th edition, Lange & McGraw Hill.
4. Mescher, Junqueira's Basic Histology: Text and Atlas, 12th edition, 2009, Lange & McGraw Hill.
5. Sadler,TW, Langman's Medical Embryology, 12th edition, Lippincott Williams & Wilkins.
6.Moore Clinically Oriented Anatomy, 2013, 7th edition, Lippincott Williams & Wilkins.
7. Gardner & Shoback, Greenspan's Basic & Clinical Endocrinology, 9th edition, 2011, Lange & McGraw Hill.
8. Kleigman, Stanton, et al. Nelson's Textbook of Pediatrics, 19th edition, Elsevier.
9. Insel&Ross, Nutrition, 5th edition.
10. Robbins & Cotran Pathologic Basis of Disease, 8th edition, 2009, Saunders.
11. Herring, W, Learning Radiology, 2nd edition, 2011, Elsevier.
12. Vaughn, L, Bioethics: Principles, Issues and Cases, 2nd edition, 2012, Oxford University Press.
13. Sawyer, S. Pediatric Physical Examination & Health Assessment.
14. Guide to Physical Examination and History Taking, 11th edition, 2012, Lippincott Williams & Wilkins.
15. Perry and Potter, Clinical Nursing Skills & Techniques,7th edition, 2009.
16. O'Sullivan, Physical Rehabilitation, 6th edition.
17. Henry's Clinical Diagnosis and Management by Laboratory Methods, 2011.
32
Course Study Guide
Hematology and Immunology System
SECOND YEAR TWINNING PROGRAMME
FACULTY OF MEDICINE PADJADJARAN UNIVERSITY
ACADEMIC YEAR 2014 – 2015
33
1. Rational / Synopsis
In this system the students will learn the basic science and clinical aspect in hematology and immunology diseases.
2. Intended Competency
Fulfilled SKDI 1-4
3. Number of SCU and length of week
8 SCU in 8 weeks
4. General learning outcome
After completing this system the students should be able to review the embryology, anatomy, physiology, biochemistry that related to the hematology and immunology
system and the epidemiology, pathogenesis, pathophysiology, diagnosis and management of diseases in the hematology and immunology system. This module is
designed to provide basic and core understanding of biomedical program especially for hemato-immunology system. Basic principle of hemato-immunology system will
serve as fundamental basic science for further clinical application.
5. Specific Learning Objectives
No. Department
Specific Learning Objectives
Delivery Method
1.
Explain the anatomy of spleen &
liver and their related organs
Lab Act: Lymphoid MDE, SOCA
organ
Anatomy
Identify and describe the gross
anatomy of the organs and
tissues of the lymphatic system
Assessment
Method
Tutorial:
Identify the major lymphatic
vessels, lymph nodes, and
organs of the lymphatic system
2.
Histology
Explain the histology of the
organs and tissues of the
lymphatic system including
lymph node, spleen and tonsils
Lab Act: Week 7
Physiology

Explain the structure
function of RBC
and
Mescher,
Junqueira's Basic
Histology:
Text
and Atlas, 12th
edition,
2009,
Lange & McGraw
Hill.
MDE, SOCA
Guyton and Hall,
2011, Textbook of
Tutorial:
Tutorial:
Moore KL and
Dalley AF. Clinically
Oriented Anatomy.
5th Edition.
Lippincott Williams
& Wilkins. 2006 pp
44-45
MDE, SOCA
Explain the structure and
function from organs and
tissues of the lymphatic system
including lymph node, spleen
and tonsils
3.
Reference
Relation to the
rule as doctors








List organs producing the
RBCs
Explain the erythropoiesis
(including
normal
and
abnormal maturation)
Explain
the
role
of
erythropoietin and tissue
oxygenation in the regulation
of RBC production
Explain the role of several
factors involved in the
maturation of RBC
Explain the development,
structure and function of
haemoglobin.
Explain the mechanism of
RBC destruction
Explain the erythropoiesis
dependent on age (including
normal
and
abnormal
maturation)
Describe the condition cause
tissues hypoxia
Medical
Physiology, 12th
Edition, Elsevier.
Lab Act:
Hematopoeisis
Mini Lecture:
Hematopoeisis
Normal
abnormal
maturation
blood cells
and
of
Skill Lab:
Blood Smear
4.
Biochemistry
Explain the role of iron, vit Tutorial:
B12 and folic acid for RBCs
production
Explain the metabolism of
iron, vit B12 and folic acid
5.
Cellular
Biology

Explain Genetics of cell
antibodies.

Explain Genetics of HLA
MDE, SOCA
Harper's
Illustrated
Biochemistry,29th
edition, Lange &
McGraw Hill.
Gardner, E.J. 1983.
Human Heredity.
John
Wiley
and
Sons Inc.
system.
Explain Genetics of ABO
Blood Groups and RH system.

Explain Genetics of Serum
Proteins: Haptoglobins and
transferring.






6.
Clinical
Pathology
Explain
Antigen
and
Antigenicity of the semen.
Explain
Antisperm
antibodies in women and in
men.
Explain Antibody against
seminal components .
Explain Immunoglobulins in
the fluid of male reproductive
tracts.
Explain Sperm agglutination
and immobilization which is not
by antibody.
Analyze
the
laboratory
assessment of RBC (number, Hb
content, Hct, Erythrocyte Index,
Red Cell Distribution Width
Reticulocyte, Peripheral blood
smear

Explain the development
and morphology of
Erythropoietic system
Tutorial:
Harmening
DM.
Clinical Hematology
and Fundamentals
of Hemostasis. 4th
edition.
Philadelphia.
FA
Davis
Company.
2002
Lab
Act:
Morphology
of
Normal
Blood
Cells
Wintrobe’s Clinical
Hematology. Tenth
Edition.
Philadelphia,
Lippincott
Williams&Wilkins.




1999
Explain the development
and morphology of
Granulopoietic system
Explain the development
and morphology of
Megakaryopoietic system
Explain the development
and morphology of the
Lymphopoietic system
Explain maturation changes
in all blood cells, such as:
size, chromatin, shape, and
cytoplasm.
Mini Lecture:
Explain
the
hemostasis
physiology
of
Hemostasis,
Thrombosis
Infection
and
Apply Diagnostic approach to
bleeding disorder (hemorrhagic
and thrombotic diseases)
Classify vascular disorders
Mini Lecture:
Trombosis
Explain
the
etiology, disorders
patophysiology, sign and Laboratory aspects
symptoms,
management, of
homeostasis
prognosis
of
vascular
disorders.

Explain the definition of
platelet disorders.
 Explain the platelet function
in
hemostasis
and
thrombosis.

distinguish the types of
platelet disorders.
 Explain the etiology of
platelet disorders.
 Explain the pathogenesis of
platelet disorders.
 Explain the signs and
symptoms
of
platelet
disorders.
 Apply the laboratory findings
of platelet disorders.
 Explain
the
differential
diagnosis
of
platelet
disorders.
 Explain the management of
platelet disorders.
 Explain the course and
prognosis
of
platelet
disorders (C4).

Explain the course of
platelet disorders due to
infection (Dengue fever).
Explain basic concept of
blood transfusion, reaction of
blood transfusion and stem cell
transplantation
disorders
Tutorial:
Lab activity:
Torniquette test
Bleeding time test
Wintrobe’s Clinical
Hematology. Tenth
Edition.
Philadelphia,
Lippincott
Williams&Wilkins.
1999
Mini Lecture:
Explain
the
principle
Immunodiagnostic.
of
Explain the definition, mechanism
and
classification
of
immunodeficiency.
Immunodiagnostic
Parslow TG, Stites
DP,
Terr
AI,
Imboden
JB.
Medical
immunology. Tenth
edition. McGraw-Hill
Co.
Appleton
&
Lange. 2003
Mini Lecture:
Immunodeficiency
Explain
immunotolerance,
immunostimulance,
and
immunosupression.
Apply laboratory assays
establish
the
diagnosis
Rheumatoid Arthritis
8.
Internal
Medicine





to
of
Explain the definition of
anemia.
Assess the symptoms of
anemia in adult and children.
Identify physical signs of
anemia in adult and children.
Evaluate
the
laboratory
findings of anemia.
Classify RBC disorders into 3
categories.
Henry's
Clinical
Diagnosis
and
Management by
Laboratory
Methods, 2011
Tutorial:
Beutler E, Coller BS,
Lichtman MA, Kipps
TJ, Seligsohn U.
Williams
Hematology. Sixth
edition. New York.
McGraw-Hill. 2001











Explain the definition of iron
deficiency anemia.
Explain the etiology of iron
deficiency anemia in adult
and children.
Explain the pathogenesis of
iron
deficiency
anemia
including the stages in the
development
of
iron
deficiency.
Explain signs and symptoms
of iron deficiency anemia in
adult and children.
Evaluate
the
laboratory
findings of iron deficiency
anemia (C6).
List the differential diagnosis
of iron deficiency anemia
(C6).
Explain
evaluate
the
management
of
iron
deficiency anemia (C6).
Explain the course and
prognosis of iron deficiency
anemia
Explain the definition of
hemolysis and hemolytic
anemia.
Classify
the
types
of
hemolytic anemia into 2
categories.
Explain
the
etiology,
pathogenesis
and
pathophysiology of hemolytic
anemia.
Skill Lab:


History Taking
Anemia
Physical
Examination of
anemia
Lawlor
Fischer
Manual of Allergic
and
Immunology.
Diagnosis
and
Theraphy. 1st ed
Boston.
LITTLE,
Brown
and
company. 1981












Explain the signs and
symptoms
of
hemolytic
anemia.
Evaluate
the
laboratory
findings
of
hemolytic
anemia.
Explain
the
differential
diagnosis
of
hemolytic
anemia.
Explain the complications of
hemolytic anemia including 2
types of crisis in hemolytic
anemia.
Explain the management of
hemolytic anemia including
the
indication
of
splenectomy.
Explain the course and
prognosis
of
hemolytic
anemia.
Explain
the
course
of
hemolytic anemia due to
infection
(Malaria).(TropMed)
Explain the definition of
aplastic anemia.
Explain the etiology of
aplastic anemia ..
Explain the pathogenesis
and
pathophysiology
of
aplastic anemia ..
Explain the signs and
symptoms
of
aplastic
anemia.
Explain
the
laboratory
findings of aplastic anemia.
Explain the severity of
aplastic anemia.
 Explain
the
differential
diagnostic
of
peripheral
pancytopenia.
 Explain the management of
aplastic anemia.
 Explain outline the course and
prognosis of aplastic anemia
 Explain the definition of
aplastic anemia.
 Explain the etiology of
aplastic anemia.
 Explain the pathogenesis
and
pathophysiology
of
aplastic anemia.
 Explain the signs and
symptoms
of
aplastic
anemia.
 Apply the laboratory findings
of aplastic anemia.

differentiate the severity of
aplastic anemia.
 Explain
the
differential
diagnostic
of
peripheral
pancytopenia.
 Explain the management of
aplastic anemia.
 Explain the course and
prognosis of aplastic anemia.
 Explain the definition of
megaloblastic anemia.
 Explain the etiology of
megaloblastic anemia.
 Explain the pathogenesis
and
pathophysiology
of














megaloblastic anemia.
Explain the etiology of folic
acid and cobalamin (vitamin
B12) deficiency.
Explain the pathogenesis of
folic acid and cobalamin
deficiency.
Explain the signs and
symptoms of folic acid and
cobalamin deficiency.
examine the laboratory
findings of folic acid and
cobalamin deficiency.
Explain
the
differential
diagnosis of folic acid and
cobalamin deficiency.
Explain the treatment of folic
acid
and
cobalamin
deficiency.
Explain the course and
prognosis of folic acid and
cobalamin deficiency.
Explain the structure and
maturation of leucocytes
(normal and abnormal).
Explain the function of
leucocytes.
Explain the definition of MDS
and acute leukemia.
Explain the types of acute
leukemia into 2 categories.
Explain the etiology of MDS,
acute myelogenous leukemia
(AML)
and
acute
lymphoblastic
leukemia
(ALL).
Explain the pathogenesis of,
Tutorial:
Skill Lab:


History taking
of
hematological
malignancy
Physical
examination of
MDS, AML, and ALL.
explain the classification of
MDS, AML, and ALL.
 Explain the signs and
symptoms of MDS, AML ,
and ALL.

examine the laboratory
findings of MDS, AML, and
ALL.
 Explain
the
differential
diagnosis of MDS, AML, and
ALL.
 Explain the management of
MDS, AML, and ALL.
Explain the course and prognosis
of MDS, AML, and ALL










Explain the definition of
chronic leukemia.
Classify the types of chronic
leukemia into 2 categories .
Explain the etiology of clinic
myelogenous
leukemia
(CML)
and
chronic
lymphocytic leukemia (CLL).
Explain the signs and
symptoms of CML and CLL.
examine the laboratory
findings of CML and CLL.
Explain
the
differential
diagnosis of CML and CLL.
Explain the management of
CML and CLL.
Explain the course and
prognosis of CML and CLL.
Explain morphology,
structure, taxonomy,

hematological
malignancy
Differential
Count
Lab activity:
Abnormal
maturation
blood cell
of
Mini Lecture:
Immune Response in












replication and cell response
to HIV infections .
Explain pathogenesis and
pathology of HIV infection .
Explain immunologic process
in immunodeficiency of HIV
infection .
Explain opportunistic
infection due to HIV
infection such as
Cryptococcus infection,
Pneumonitis carinii, Candida
infection, etc. . TropMed
Explain
transmission
of
infection, the prevention and
features of HIV infection .
Explain laboratory diagnostic
of HIV infection
Explain the definition of
polycythemia
vera
and
myelofibrosis
Explain the etiology of
polycythemia
vera
and
myelofibrosis
Explain the pathogenesis of
polycythemia
vera
and
myelofibrosis
Explain the signs and
symptoms of polycythemia
vera and myelofibrosis
Explain
the
laboratory
findings of polycythemia
vera and myelofibrosis
Explain
the
differential
diagnosis of polycythemia
vera and myelofibrosis
Explain the management of
Infection
Skill lab:
Infectious
disease
corpse management
Mini Lecture:
Leukocyte
Disorder
polycythemia
vera
and
myelofibrosis

Explain the course and
prognosis of polycythemia vera
and myelofibrosis













Describe the structure of
plasmocyte .
Explain the definition of
multiple myeloma .
Explain the etiology of
multiple myeloma .
Explain the pathogenesis of
multiple myeloma .
Explain the signs and
symptoms
of
multiple
myeloma .
Explain
the
laboratory
findings
of
multiple
myeloma.
Explain
the
differential
diagnosis
of
multiple
myeloma .
Explain the management of
multiple myeloma .
Explain the course and
prognosis
of
multiple
myeloma .
Explain the definition of
lymphadenopathy
(lymph
nodes enlargement) ..
Explain the etiology of
lymphadenopathy .
Explain the definition of
malignant lymphoma ..
Classify
the
types
of
malignant lymphoma into 2
Tutorial:








categories .
Describe the classification of
Non-Hodgkin
Malignant
Lymphoma
(NHML)
(Rappaport,
Lukes-Collin,
Working
Formulation,
REAL/WHO) .
Describe the classification of
Hodgkin’s
disease
(Rye
classification) .
Explain the etiology of
malignant
lymphoma
including its relation with
HIV
Explain the pathogenesis of
malignant lymphoma.
Explain the signs and
symptoms
of
malignant
lymphoma.
Explain
the
differential
diagnosis
of
malignant
lymphoma.
Explain the management of
malignant lymphoma.
Explain the course and
prognosis
of
malignant
lymphoma.
Explain the etiology, clinical
manifestations,
patophysiology,
differential
diagnosis, management, lab
support,
prevention
and
prognosis of vasculitis
LA :


Histology of
Lymphoid Organ
Lymph node
Hiperplasia,Malig
nan Lymphoma
and Thymoma
Explain the etiology, clinical Tutorial:
manifestations,
patophysiology, differential
diagnosis, management, lab
support, prevention and
prognosis
of
Lupus
erytematosus
Klippel, Primer on
the
Rheumatic
Diseases, 2003
Explain the etiology, clinical
manifestations,
patophysiology, differential
diagnosis, management, lab
support, and prognosis of
Rheumatoid arthritis
9.
Pediatrics








Explain the mechanism of
coagulation in hemostatic
mechanism.
Explain the definition of
hemophilia.
Classify
the
types
of
hemophilia.
Explain the etiology of
hemophilia A, B and C.
Explain the etiology of
Hemophilia A, B and C.
Explain the signs and
symptoms of Hemophilia.
explain
the
laboratory
findings of Hemophilia A, B
and C.
Explain
the
differential
diagnosis of Hemophilia A, B
Tutorial:
Kleigman,
Stanton, et al.
Nelson's Textbook
of Pediatrics, 19th
edition, Elsevier.












and C.
Explain the management of
Hemophilia A, B and C.
Explain the course and
prognosis of Hemophilia A, B
and C.
Explain the definition of von
Willebrand disease.
Explain the function of von
Willebrand factor.
distinguish the types of von
Willebrand disease.
Explain the etiology of von
Willebrand disease.
Explain the pathogenesis of
von Willebrand disease.
Explain the signs and
symptoms of von Willebrand
disease.
Apply the laboratory findings
of von Willebrand disease.
Explain
the
differential
diagnosis of von Willebrand
disease.
Explain
the
treatment
(management)
of
von
Willebrand disease.
Explain the course and
prognosis of von Willebrand
disease.
Explain
the
patophysiology,
etiology,
sign and
Tutorial:
symptoms,
prognosis
management,
of
Coagulation
disorders (Haemorrhagic Diseases
of the Newborn/ HDN)
Explain
the
etiology,
patophysiology, sign and
symptoms,
management,
prognosis
of
Fibrinolysis
disorders
Explain
the
etiology,
patophysiology, sign and
symptoms,
management,
prognosis
of
Thrombotic
disorders
10.
Microbiology
Apply basic
immunology
concept
of Mini lecture:
Basic immunology
The Recognition of Antigen Mini Lecture:
and Antibody :
Complement

The structure and function of
system
antibodies


Major Histocompatibility Complex
Antigen processing and presentation
Immunity and Immune
MHC and immune
response
Jawetz
Medical
Microbiology
Response :
Explain :




Active immune response
Passive immune response
Innate immunity
Adaptive immunity
AIDS and Lentivirus :





Classification of HIV
Replication
Route of transmission
Laboratory diagnosis
Treatment.
Explain
the
mechanism
of
inflammation
reaction
and
structure of immuno competent
cells which happened.
11.
Pharmacology
Explain
classification
hemopoeitic agents
of Tutorial:
Explain
pharmacological Mini Lecture:
properties of
hemopoeitic
Immunomodulator
agents
and
Immunosupresive
Explain
classification
immunosupressant
Explain
Properties
of
Pharmacological
of
Katzung, B.G. et
al. in Basic and
Clinical
Pharmacology
11th
edition.
Singapore:
McGraw-Hill
Companies.2009.
Immunosupressant
Explain
classification
immunosupressant
of
Explain
Pharmacological
Properties
of
Immunosupressant
12.
Pathology
Anatomy
Explain the pathogenesis type Tutorial:
I to IV hypersensitivity and its
diseases
Explain the pathogenesis and Mini lecture:
microscopic feature of chronic
allergic rhinitis (nasal polyp),
and urticaria
Describe the diseases of Lab activity:
autoimmune and its general
Histopathology of
pathogenesis
Lymph
Node
Hyperplasia
Malignant
Lymphoma
Explain the pathogenesis of
several autoimmune diseases
and its microscopic feature:
systemic lupus erythematosus,
polymialgia
rheumatic,
anafilactic reaction, rheumatic
Robbins & Cotran
Pathologic Basis of
Disease,
8th
edition,
2009,
Saunders.
fever, rheumathoid artritis
Explain the pathogenesis of
acquired immunodeficiency
syndrome
Explain the disorders of white
blood cells ( acute and chronic
leukemia),
lymph
node
(lymphoma hodgkin and non
Hodgkin
lymphadenopathy,
lymphadenitis), spleen and
thymus (timoma)
Explain the pathogenesis and
microscopic appearance of
reactive hyperplasia of the
lymph node and sinus
histiocytosis
Explain the pathogenesis and
microscopic appearance of
hodgkin’s and non hodgkin’s
lymphoma
Explain the basic concept of
tumor imunity
13.
Dermatology


Explain
structure
and
function of the skin and
appendages.
Explain definition of atopy
and atopic dermatitis .
Mini Lecture:
Atopy
Freedberg IM, et al.
Fitzpatrick’s
Dermatology
in
General
Medicine.
Sixth
Edition.





Explain etiopathogenesis of
atopic dermatitis, especially
itch
and
environment
factors.
Explain clinical manifestation
and classification of atopic
dermatitis.
Apply laboratory assays to
establish the diagnosis of
atopic dermatitis .
Explain differential diagnosis
of atopic dermatitis .
Explain the management of
atopic dermatitis .
McGraw
York.
Hill.
New
Tutorial:
Skill lab:
History Taking in
Allergic
&
Immunologic
Disease
Skill lab:
Physical
examination
in
pediatric allergy &
immunology
Explain the etiology, sign &
symptoms,
patophysiology,
differential
diagnosis,
management, lab support and
prognosis of urticaria and
angioedema
Explain the etiology, clinical
manifestations,
patophysiology,
differential
diagnosis, management, lab
Odom RB, James
WD, Berger TG.
Andrew’s diseases
of the skin. 9th ed.
Philadelphia,
WB
Saunders Company.
support,
prognosis
shock
prevention
and
of anaphylactic
Explain the etiology, clinical Tutorial:
manifestations,
patophysiology,
differential
diagnosis, management, lab
support,
prevention
and
prognosis of drug eruption
Explain the etiology, clinical Tutorial:
manifestations,
patophysiology,
differential
diagnosis, management, lab
support,
prevention
and
prognosis of allergic contact
dermatitis
Explain the etiology, clinical
manifestations,
patophysiology,
differential
diagnosis, management, lab
support,
prevention
and
prognosis of chronic bullous
disease
14.
ENT
Explain definition and etiology of Skill lab:
allergic rhinitis
Physical
examination
special
and
Scott-Browns
Otolaryngology,
Allan G. Kerr. 6th ed
editor
Ian
S.
Mackey. And T.R.
investigation
ENT
Explain
pathophysiology,
differential
diagnosis,treatment
and prognosis of non allergic
rhinitis
Explain non allergenic etiology of
allergic rhinitis
Explain
the
classical
pathophysiology
of
hypersensitivity type I of allergic
rhinitis
Explain sign and symptoms,
management and prognosis of
allergic rhinitis
in
Bull.
Vol.
4
Rhinology,
1997
Butterworths
London
Boston
Durban Singapore,
Sidney
Toronto,
Wellington
Course Study Guide
Neurobehavior System
SECOND YEAR
FACULTY OF MEDICINE PADJADJARAN UNIVERSITY
ACADEMIC YEAR 2014 – 2015
1. Rational / Synopsis
In this system the students will learn the basic science and clinical aspect in neurobehavior and special sense diseases.
2. Intended Competency
Fulfilled SKDI 1-4
3. Number of SCU and length of week
8 SCU in 9 weeks
4. General learning outcome
After completing this system the students should be able to review the embryology, anatomy, physiology, biochemistry that related to the cardiovascular system and the
epidemiology, pathogenesis, pathophysiology, diagnosis and management of diseases in the neurobehavior and special sense system.
5. Specific Learning Objective
No
Department
Specific Learning Objective
Delivery method
Assessme
nt
methods
Reference
Relation
to the
rule as a
doctors
1.
Anatomy
1.1 Peripheral Nerve
1.1.1. General concept of peripheral nerve
(motor, sensory, otonom) : Root, dorsal
root ganglion, plexus, peripheral nerve,
neuromuscular junction
1.1.2. Anatomy, embriology, and physiology :
posterior (dorsal) and anterior (ventral)
root; dorsal root ganglion; brachial and
lumbar plexus; peripheral nerve (median,
ulnar, radial, musculocutaneus, sciatic,
femoral, tibial, sural and peroneal nerve
1.2 Spinal Cord
LA :
Basic Anatomy &
Embryology of CNS,
Anatomy of
Peripheral Nerves &
connection to Spinal
Cord (Week I)
1.2.3. Explain Axial section of Cervical, Thoracal,
Lumbar, Sacral.
1.2.4. Explain spinal cord vascularization
(artery and venous)
Clinically Oriented
Anatomy : Moore
&Dalley
MDE, SOCA
Clinically Oriented
Anatomy : Moore
&Dalley
TR :
TR :
1.2.1.
Embryologi,Anatomy,Histology,Physiol
ogy of Spinal Cord
LA :
1.2.2. Explain Descending and Ascending
pathway of Spinal Cord
MDE, SOCA
Anatomy of Cranial
Nerves &Brain; Basic
concept of
Somatosensory
System, Dermatome
& Myotome
1.2.5. Explain meningeal layer of spinal
cord.
1.3. Brain
1.3.1. Explain the Cerebral vascularization and
autoregulation
TR:
1.3.2. Explain the structure of Motor and sensory
LA : Neuro-Anatomy
Motor System ;
Physiology of Posture
& Movement; Basic
concept of UMN &
LMN
pathway
1.3.3. Explain the structure of Cortical and
Subcortical function, Cranial nerves, Limbic
system and Brain Stem
MDE, SOOCA
Clinically Oriented
Anatomy : Moore
&Dalley
MDE, SOOCA
Clinically Oriented
Anatomy : Moore
&Dalley, p. 180181
TR :
1.3.4. Explain and Evaluate Anatomy of
Meningeal layer of Brain, Brain
Hemisphere, Cerebral fluid system, Brain
stem and Cranial Nerve (CN.I, III-IV-VI, V,
VII, IX-X, XI, XII).
1.3.5. Explain and Evaluate Anatomy of Brain
Vascularization, Circle of Willis, Cerebral
blood flow, Blood Brain Barrier and
Descending tract of brain : Corticospinal
tract, corticobulber tract
1.4. High Cortical Function
1.4.1. Explain the anatomy of cerebral cortex
1.4.2. Explain anatomy of the organ that related
to Epilepsy and Shizophrenia (limbic
system and cerebral lobes)
TR :
TR:
LA : Neuro-Anatomy
of Brainstem,
Cerebellum & Basal
Ganglia ; Basic
concept of attention
& wakefulness
1.5. Special Sense
1.5.1. Explain anatomy of vestibular system and
visual system correlated with case, and
proprioception
TR:
MDE, SOCA
LA: Anatomy and
Physiology of AudioVestibular Organ
Learning objectives:
• describe the
external, middle
and inner ear
1.5.2. Explain anatomy of the eye

list the contents
of the middle ear

relate the
anatomical
structures with
common clinical
conditions
involving the ear
TR:
LA: Anatomy and
Physiology of the Eye
Learning objectives:
• enumerate the
bones forming the
orbit
• describe the
contents of the
Clinically Oriented
Anatomy : Moore
&Dalley, p. 40-43
orbit (extraocular
muscles, vessels
and nerves)
• describe the
eyeball, list the
structures passing
through the
superior orbital
fissure, optic canal
and common
tendinous ring
2.
Cell Biology
2.1 Peripheral Nerve
2.1.1. Histology of peripheral nerve : the
fascicles (schwann cells and fibrocytes,
axons, myelin sheats, collagen fibrils of
endoneurium), connective tissue sheats
(endoneurium, perineurium and
epineurium), structure of neuron,
dendrit, axon, morphologic type of
neuron, nodes of ranvier and internodal
segment of schwann cells, type of
synaptic cleft
2.1.2 Histology and
neuromuscular junction
embriology
MDE, SOCA
TR :
of
2.2 Spinal Cord
2.2.1.Explain Embryology and Histology of
Spinal Cord
TR :
MDE, SOCA
2.3 Brain
2.3.1.Explain Histology of Meningeal layer,
Brain Hemisphere of Brain and
Cerebral fluid system.
TR:
SOOCA, MDE
2.4 High Cortical Function
TR :
2.3.1.Explain the histology of cerebral cortex
SOOCA, MDE
ML:
Life Cycles of Human
Being
2.5 Development of brain
2.5.1. Explain the development of human
brain
TR:
SOOCA, MDE
2.5.2. Explain the histology of human brain
2.6 Special Sense
2.6.1. Explain the histology of vestibular
system and visual system correlated
with case
2.6.2. Explain histology of the eye
TR:
SOOCA, MDE
TR:
SOOCA, MDE
3.
Physiology
3.1 Peripheral Nerve
3.1.1. Physiology of peripheral nerve : nerve
impuls potential (resting potential,
action potensial : depolarization and
repolarization), conduction impulses.
3.1.2. Classification of nerve fiber
(Myelinated and non-myelinated;
somatic and autonomic; motoric and
sensoric; based on conduction velocity,
diameter and function)..
3.1.3. Physiology of peripheral nerve : nerve
impuls potential (resting potential,
action potensial : depolarization and
repolarization), conduction impulses.
3.1.4. General concept of lower motor neuron
(sensoric, motoric and reflexes).
3.2 Spinal Cord
3.1.1. Explain the Physiology of Spinal Cord
TR :
ML:
Myelinization
Neuronal
Transmission
SOOCA,
MDE,
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
&
TR :
MDE, SOCA
3.1.2. Explain Otonomic Function of Spinal
Cord ( Simpatis, parasimpatis, miction,
defecation)
3.1.4. Explain Motoric pathway and function
of spinal cord (Myotome)
3.1.4. Explain Sensoric pathway, type and
function of spinal cord (Dermatome)
3.1.4. Explain reflex arch in spinal cord
3.3 Brain
3.3.1. Explain the Cerebral vascularization
and autoregulation
TR:
MDE,SOOCA
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
3.3.2 Explain the Structure and function of
Motor and sensory pathway
3.3.3 Explain the Signal transduction and the
Signal Communication mediated by
neurotransmitter, cytokines and
eicosanoids
3.3.4 Explain the Physiology of Meningeal
layer of Brain, Brain Hemisphere,
Cerebral fluid system and Brain stem.
3.3.5 Explain and Evaluate the Physiology of
Consciousness and Cranial Nerve
(CN.I, III-IV-VI, V, VII, IX-X, XI, XII)
3.3.6 Explain and Evaluate the Physiology of
the descending tract of brain :
Corticospinal tract, corticobulber tract,
Brain Vascularization, Circle of Willi,
Blood Brain Barrier and Cerebral blood
flow
3.3.7 Explain physiology of neurotransmitter
related to movement regulation (basall
ganglia and extrapyramidal system)
TR :
LA :
Physiology
of
Posture
&
Movement; Basic
concept of UMN &
LMN
MDE,SOOCA
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
ML :
1.Brain Plasticity
2.Physiology
Equilibrium
of
3.4 High Cortical Function
3.4.1 Explain the physiology of cerebral
cortex
3.4.2 Explain the the concepts of cognition
and memory and higher cortical
function.
TR :
MDE
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
3.4.3 Explain physiology of the organ that
related to Epilepsy (limbic system and
cerebral lobes)
TR:
MDE,SOOCA
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
ML:
1. Life Cycles of
Human Being
2. Brain Death
3.5 Development
3.5.1 Explain the brain function regarding :
Consciousness, Emotion, Motor
behavior (Conation), Thinking, Speech,
Perception, Memory, Intelligence,
Insight, and Judgment
TR:
MDE
LA: The Limbic SOCA
System : Emotion &
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
Personality;
Memory
Learning
London
&
3.6 Special Sense
3.6.1 Explain the physiology of vestibular
system, visual system correlated with
case, and proprioception
TR:
MDE
ML :
SOCA
Physiology of
Equilibrium
3.6.2 Explain the pathophysiology of
decreased visual acuity
3.6.3 Explain the visual pathway and
physiology of vision
4.
Neurology
TR:
MDE
SOCA
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
Guyton AC.
Textbook of
medical
physiology. WB
Saunders Co.
London
4.1 Peripheral Nerve
4.1.1 Explain the Topography of sensoric
distribution (dermatomes, myotomes
and sclerotomes)
4.1.2 Explain the Pathomechanism
degeneration of peripheral nerve disease
(pathologic reaction of neuron :
wallerian degeneration, axonal
degeneration and demyelinating
degeneration; remyelinitation)
4.1.3 Explain the Patophysiology of
peripheral nerve disease (neurotmesis,
axonotmesis, avulsion)
TR :
MDE
SOCA
SL :
MOTOR
AND OSCE
SENSORY
EXAMINATION
ML:
Basic Concept of
Pain
Mechanism
focusing
on
Adams R. D., et al
: principal of
neurology vol.1,
VI at McGrawHill, New York,
1997, p.13461445.
4.1.4 Explain the Pathomechanism of neuro
muscular junction disease.
4.1.5 Explain the Positive and negative
symptom of peripheral nerve disease.
4.1.6 Explain the Classification of peripheral
nerve disease, based on location :
radiculopathy, plexopathy, neuropathy
(mononeuropathy, polineuropathy,
mononeuropathy multiplex).
4.1.7 Explain the Etiology, clinical
characteristic, diagnostic, differential
diagnostic, management, prognosis of
peripheral nerve disease.
4.1.8 Explain the Definition, classification,
precipitating factor, Patophysiology and
patomechanism, Clinical manifestation,
differential diagnostic, and diagnostic
tools, Management, complication and
prognosis of Guillain barre syndrome
4.1.9 Explain the BHP, PHOP, and
medicolegal aspect of Guillain barre
syndrome.
4.2 Spinal Cord
neuropathic pain
4.2.1 Explain the definition and incidence and
pathogenesis, complication and
management of spinal cord disease
4.2.2 Explain the classification of spinal cord
disease (Neoplasm, Vasculer,
Inflamation, Infection,
Trauma,Degenerative)
4.2.3 Explain the complete (transvere) lesion
in spinal cord and the incomplete lesion
in spinal cord : Hemilesion (Brown
TR :
MDE
1.
SOCA
OSCE
SL :
REFLEXES
AND
MENINGEAL SIGN
EXAMINATION
2.
Adams RD,
Maurice V,
Ropper AH.
Principles of
Neurology,
6th
ed,
1997:766775; 874-901
Rowland LP.
Head Injury
in Rowland
LP
(Ed).
Sequard, Anterior cord syndrome,
Central cord syndrome, Posterior cord
syndrome).
4.2.4 Explain the Physical Examination in
spinal cord disease
3.
Merritt’s
textbook of
neurology 9th
ed. Williams
and Wilkins,
Baltimore,19
95:350-335;
417-440
NarayanRK,
Wilberger JE.
Povlisshock
JT,
Neurotrauma,
McGrawHill,
New
York, 1996
4.3 Brain
TR:
4.3.1 Explain pathophysiology of cerebral
vascular damage i.e., stenosis/occlusion,
Intracerebral hemorrhage, sub
arachnoids hemorrhage (aneurysm,
avm, cavernous angioma, cavernoma,
etc), lacunar.
SL:
4.3.2 Explain Explain pathology of cerebral
vascularization i.e., stenosis/occlusion,
Intracerebral hemorrhage, sub
arachnoids hemorrhage (aneurysm,
avm, cavernous angioma, cavernoma,
etc), lacunar.
4.3.3 Understand the definition of stroke
Analyze the classification of carotid system
stroke and vertebro-basiler system
MDE
1.
Gilman S.
Manter and
Gatz’s
Essentials of
Clinical
Neuroanato
my and
Neurophysiol
th
ogy, 8 ed.
FA Davis
Company,
USA,1992
2.
DeMyer W.
Neuroanato
nd
my 2 ed.
Williams and
Wilkins-A.
Waverl Co,
SOCA
CRANIAL
NERVE
EXAMINATION
USA,1998
stroke
4.3.4 Explain the definition, incidence,
classification, differential diagnosis,
Mechanism, Pathogenesis, sign and
symptom, Complication (Neurological,
non-neurological, psychososial,
principle management by type of stroke
and principle rehabilitation and
prognosis of stroke of Stroke
4.3.5 Explain the Risk Factors, Prevention
(Primary and secondary) and BHP,
PHOP, CRP aspect of stroke
4.3.6 Explain the incidence, definition,
pathophysiology, clinical & etiological
classification, the signs and symptoms,
of Parkinson
4.3.7 Understand the
neuroimmunoendocrinology of
Parkinson
4.3.8 Analyze of the anamnesis, the general
examination, the neurological
examination, the neuro-imaging, the
clinical pathology, diagnosis,
complication and prognosis of
Parkinson
4.3.9 Explain the management of Parkinson,
include promoting, preventing, curative
and rehabilitative, the pharmacological
properties of cholinergic agonist and
antagonist and the medicolegal aspect
of Parkinson
4.4 High Cortical Function
3.
TR :
MDE
SOOCA
SL :
MMSE & GCS
EXAMINATION
OSCE
Victor M,
Ropper AH.
Adams and
Victor’s
Principles of
th
Neurology 7
ed. USA.
McGraw-Hill,
2001:821924
Victor M, Ropper
AH. Adams and
Victor’s Principles
th
of Neurology 7
ed. USA. McGrawHill, 2001:99-120
4.4.1 Explain the definition, epidemiology
and the classification of epilepsy and
seizure (ILAE) of epilepsy and seizure
4.4.2 Explain the brain neurotransmiter in
epilepsy and schizophrenia
(pathogenesis and phatophysiology).
4.4.3 Explain the principle management of
epilepsy and schizophrenia i.e.
medication, operative, life style, dietary
for epilepsy and social aspect,
rehabilitation of epilepsy /Psychosocial
in epilepsy.
4.4.4 Explain supported lab. examination for
epilepsy : Neurophysiologic/ EEG and
the differential diagnosis of seizure and
epilepsy.
4.5 Special Sense
TR:
4.5.1 Explain the incidence, sign and
symptoms, general examinations, and
neurological examinations of vertigo
TR:
MDE
SOOCA
MDE
SOOCA
4.5.2 Analyze classification, pathogenesis and
pathophysiology of vertigo
4.5.3 Explaining treatment of vertigo
5.
Radiology
5.1 Spinal cord injury (Trauma)
5.1.1 Explain Supporting Examination in
spinal disease (plain x-ray, CT-Scan,
MRI)
MDE
Victor M, Ropper
AH. Adams and
Victor’s Principles
th
of Neurology 7
ed. USA. McGrawHill, 2001:99-120
Victor M, Ropper
AH. Adams and
Victor’s Principles
th
of Neurology 7
ed. USA. McGrawHill, 2001:99-120
5.2 Epilepsy
5.2.1 Explain supported lab. examination for
epilepsy : Neuroimaging of choice for
epilepsy
TR:
MDE,
TR:
5.3 Benign Paroxismal Vertigo
5.3.1 Explaining the laboratory findings and
neuroimaging of vertigo
6.
Psychiatry
TR:
MDE,
ML :
MDE
6.1 Post Traumatic Stress Disorder (PTSD)
6.1.1 Explain the differentiation of normal
and abnormal Anxiety
1. Basic Concept OSCE
of Mental
6.1.2 Explain the distinction between fear and
Health
anxiety
2. Psycho
pharmacology
6.1.3 Explain the classification and peripheral
and
manifestations of anxiety disorders.
Neurotransmit
(DSM-IV-TR and PPDGJ-III)
ter
6.1.4 Explain the criteria diagnosis, clinical
feature, comorbidity, epidemiology and
etiology (stressor, risk factors,
predisposing vulnerability factors) of
Post Traumatic Stress Disorder (PTSD).
(DSM-IV-TR and PPDGJ-III)
6.1.5 Explain the psycho-pathogenesis
(psychodynamic and CognitiveBehavioral factors) and
psychopathology (symptomatology) of
PTSD
Sadock BJ,
Sadock VA.
Kaplan &
Sadock’s Synopsis
of Psychiatry,
Behavioural
Science/Clinical
Psychiatry, 9th ed.
Lippincott
Wilkins&Wilkins,
Hpiladelphia,
2003
6.1.6 Explain the biological factors of PTSD
(norepinephrine, dopamine, endogenous
opioids, and benzodiazepine receptors
and the hypothalamic-pituitary-adrenalHPA axis)
6.1.7 Explain the precipitating factor,
principle of PTSD management
(psychopharmacology and
psychotherapy), Course and Prognosis,
and the indication for case referral of
PTSD
6.1.8 Explain the traumatic event, trauma
type, and trauma severity and the
difference between PTSD and acute
stress disorder
6.1.9 Evaluate the BHP, PHOP, and CRP
aspect of the case.
6.2 Delirium and Dementia
6.2.1 Differentiate normal age-associated
forgetfulness, mild cognitive
impairment, dementia, delirium, and
depression
6.2.2 Explain the definition, incidence,
etiology, diagnostic criteria, differential
diagnosis, management, course and
prognosis of delirium
6.2.3 Explain the definition, incidence,
etiology, diagnostic criteria, differential
diagnosis, management, course and
prognosis of dementia
6.2.4 Explain the pathophysiology and
Neuropathology of Dementia
TR :
MDE
SL :
SOCA
PSYCHIATRIC
EXAM : Non
Psychotic Disorder
OSCE
Sadock BJ,
Sadock VA.
Kaplan &
Sadock’s Synopsis
of Psychiatry,
Behavioural
Science/Clinical
Psychiatry, 9th ed.
Lippincott
Wilkins&Wilkins,
Hpiladelphia,
2003
6.2.5 Explain the neurotransmitter
involvement in memory process and
cognition
6.2.6 Evaluate the Medico-legal, BHP,
PHOP, and CRP aspect of the case.
6.3 High Cortical Function
6.3.1 Explain the personality disorder and
personality changes in epilepsy.
6.3.2 Explain the classification of psychotic
disorder
6.3.3 Explain differential diagnosis of
schizophrenia
6.3.4 Explain the prognosis of epilepsy and
schizophrenia
TR:
MDE
SL:
SOCA
PSYCHIATRIC
EXAM : Psychotic
Disorder
OSCE
Kaplan & Sadock’s
Comphrehensive
Textbook of
Psychiatry, 8th
ed., 2005,
Kaplan & Sadock’s
Synopsis of
Psychiatry 10th
ed., 2007, 467 497
6.4 Mood and Panic Disorders
6.4.1 Explain the definition, classification , TR:
epidemiology, etiology ,
ML:
psychopathology and psychodynamic,
signs and symptoms, management ,
Coping
course and prognosis, and the
mechanism
medicolegal aspects of mood disorders
6.4.2 Explain the definition, classification ,
Brain Plasticity
epidemiology, etiology ,
psychopathology and psychodynamic,
signs and symptoms, management ,
course and prognosis, and the
medicolegal aspects of dependent
personality disorder
6.4.3 Explain the neurotransmitter involved in
mood disorder
MDE
SOCA
OSCE
1. Kaplan &
Sadocks
:Comprehe
nsive
Textbook
of
Psychiatry
9th
Ed
Lippincott,
Williams
&Wilkins2
006,p.
2. Kaplan &
Sadocks :
Synopsis of
Psychiatry
10
th
Ed.Wolters
Kluwer,Lip
pincott,Will
iams
&Wilkins2
007, p.527568..
3. Kaplan &
Sadocks
:Comprehe
nsive
Textbook
of
Psychiatry
9 th Ed
Lippincott,
Williams
&Wilkins2
006,
6.5 Mental Redardation
7.
Biochemistry
6.5.1 Explain definition and classification,
sign and symptoms, neurological and
psychiatric examination and the
management of Mental Retardation
7.1 Mental Redardation
TR:
7.1.1 Explain the normal brain
neurotransmiter
7.1.2 Explain the brain neurotransmiter in
epilepsy and schizophrenia
(pathogenesis and phatophysiology).
TR:
ML:
MDE
Basic Concept of
SOCA
Devlin.
Biochemistry and
clinical
7.1.3
8.
ClinPath
CLP
(Consultation
Liaison
Psychiatry)
Explain metabolism of the lens
correlation. 5
ed. 2002
8.1 Brain Patophysiology
LA :
MDE
CSF Examination :
Clinical Pathology &
Microbiology
10
Microbiology
9.1 Brain Patophysiology
Pediatric
9.1.1 Explain the causative agents of infections of
the central nervous system
9.1.2 Explain the epidemiology and pathogenesis
of infections of the central nervous system
9.1.3 Explain the clinical manifestation of
infections of the central nervous system
9.1.4 Explain the clinical manifestation of
infections of the central nervous system
9.1.5 Explain the clinical manifestation of
infections of the central nervous system
9.1.6 Explain the laboratory diagnosis and
interpret laboratory results of
cerebrospinal fluid examination
9.1.7 Explain the principle of treatment and
preventive of infections of the central
nervous system
10.1 Cerebral Palsy
LA: (Tropmed)
ML :
1. Aging process
of the brain
2. Drug of
Abuse
3. Infection of
CNS
MDE
th
11
Pathology
Anatomy
10.1.1 Explain definition of growth and
development
10.1.2 Explain basic principle of child growth
and development
10.1.3 Explain period of growth and
development
10.1.4 Describe factors influencing child growth
and development
10.1.5 Describe normal pattern of child growth
and development
10.1.6 Describe aspect/domain of child
development
10.1.7. Explain milestone of child development
10.1.8. Recognize screening and monitoring of
child growth and development
10.1.9. Describe normal child behavior and
milestone
10.1.10.Explain definition of cerebral palsy (CP)
11.
Describe etiology of CP
12.
Explain the sign and symptoms of CP
13.
Explain neurological examination of CP
14.
Describe radiology findings of CP
15.
Explain management of CP
11.1 Understanding the pathogenesis of hypoxia,
ischemia, infarction, hypertension
cerebrovascular disease and intracranial
haemorrage
11.2 Understanding the pathogenesis of acute
meningitis, acute focal suppurativa infection,
chronic bacterial meningoencephalitis and viral
meningoencephalitis
11.3 understanding pathogenesis of alzheimer
disease, dementia and parkinson
11.4 Understanding the pathogenesis and it”s
microscopic features of degenerative disease
TR:
MDE
SL: Pediatric
Primitive Reflex
Examination
SOOCA
LA: Pharmacological
Properties of
Epileptic Drugs
ML:
1.
Addiction
Concept
Child Growth &
Development
LAB Act
11.5 Understanding the pathogenesis and it”s
microscopis features of astrocytoma,
medullablastoma, meningioma, and
schwannoma.
11.6Understanding the pathogenesis of carpal
tunnel syndrone, GBS, Myastenia gravis, and
neuropathy
11.7 Understanding pathogenesis and
microscopic appearance of neurofibroma
11.8 Understanding the pathogenesis of
inflamation in eye ( conjungtivitis, blefaristis,
screitis, dacroadenitis, keratitis, and
endopthalmitis )
11.9 Explain kind and type of accular neoplasma