Download Rezakhani Soheila Alterations of Liver Function Tests in 134 Lichen

Rezakhani Soheila
Alterations of Liver Function Tests in 134 Lichen Planus Patients Referred to
Afzalipour Dermatology Clinic and Private Dermatologists’ Offices in Kerman
Abstract
Background: Lichen planus (LP) is an inflammatory mucocutaneous disease with
unknown ethiology that cutaneous lesions describe as flat-topped, shiny, polyangular,
purlish and pruritus papuls and plaques involving the flexors surfaces, mucous
membranes and genitalia. LP has a worldwide distribution and can be seen In any ages.
Although, the cause of LP is unknow but an immune pathogenesis is suggested by
association of this disease with systemic diseases such as OVI-ID and liver diseases.
There are changes in liver function tests (LFTS) but they are not pathogonomic for
specific liver diseases.
Objective: The assessment of changes of LFTS, in 134 patients suffering from LP in
dermatological outpatients in Kerman, Iran, in relation with age, sex, duration of disease
and involving site (cutaneous, mucosal, mucocutaneous)
Patient and Methods: In this study, 134 patients with LP were evaluated in
dermatological out patients clinics as case and 180 healthy persons as control. Diagnosis
was based on distinct clinical features, skin biopsy and pathology.
Results: from 134 patients with LP, there were 82 men and 52 women with a mean age
of 4 I years. The patients age ranged from 16 years to 76 years. In patients with high
SGPT, mean duration of disease was 13.2 months and in patients with normal SGOT, it
was 27.1 months (.P>0.05) There was no relation between sex and level of SGOT, SGPT,
Alk. rhos (P>0.05). In 61.1% patients with high SGOT, only cutaneous lesions in 38.8%
of them Muco-cutaneous lesions was seen. But anyone had not only mucosal lesions.
There fore, in patients with cutaneous lesion abnormal SGOT was seen morethan other
lesions. In 78.5% of patients with high SGOT and 76.9% of them with high Alk.
Pho, cutaneous lesions was reported. Therefore high Alk.Pho and high SGOT was seen in
patients with cutaneous lesions more than other lesions. There were high total and direct
bilirubin in 9% of patients but in control group there were these changes in 1.3 of them
(P<0.05). There was positive family history in 5 patients and other patients have not
information about being the same disease in, the same disease in the family.
Conclusion: Our findings indicate that changes of LFT (high SGOT, SGPT, Alk.pho)
was more in patients with LP than control group. Among these changes the increase was
meaningful in SGPT level.
Keywords: Lichenplanus, Clinical features, Liver function tests, Liver disease