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Sarcoidosis - Derm.TheClinics.com
Sarcoidosis - Derm.TheClinics.com

... and environmental agents have all been implicated as possible factors. There is much speculation as to whether the cause is multifactorial or caused by an antigen(s) that has not yet been identified [3]. Immunology Immunologic abnormalities found in sarcoidosis include polyclonal hyperglobulinemia [ ...
Cellulitis and lymphoedema: a vicious cycle
Cellulitis and lymphoedema: a vicious cycle

... CKS (2006) guidance recommends flucloxacillin as first-line and erythromycin or clarithromycin in the case of penicillin allergy. The suggested duration of treatment is for seven days for mild infections and 10 days for more severe forms. There is limited evidence available for the estimated duratio ...
Guidelines of care for the management of psoriasis
Guidelines of care for the management of psoriasis

... metabolic syndrome. Patients with the metabolic syndrome are at a significantly increased risk of developing cardiovascular morbidity and mortality. Although the prevalence of metabolic syndrome is elevated in most westernized countries, a recent study of hospitalized patients demonstrates that the ...
Diagnosis and Treatment of Demodectic Blepharitis
Diagnosis and Treatment of Demodectic Blepharitis

... was unsuccessful in 21.9%. With cleaning, total cure and partial improvement was observed in 28.6% and 37.5% respectively, whereas it was unsuccessful in 37.5% of cases. In conclusion, demodicosis is quite common in the eyes. It has been shown that its prevalence is higher in patients with blepharit ...
Guidelines of care for the management of psoriasis and psoriatic
Guidelines of care for the management of psoriasis and psoriatic

... vehicle (P \ .00001).15 In a double-blind, vehiclecontrolled study of 378 patients with moderate to severe psoriasis treated with clobetasol solution (class I) for 2 weeks, 81% of patients treated with clobetasol solution compared to 22% of patients treated with vehicle achieved 50% or better cleari ...
Diseases of the Skin
Diseases of the Skin

... Medical treatment should begin with a benzoyl peroxide agent because these are available over the counter and have an extensive history of safety and efficacy. They are available in a wide range of vehicles (soaps, lotions, gels), and strengths vary from 2.5% to 10%. Many patients go straight to the ...
misdiagnosed and treated as non-Hodgkin lymphoma
misdiagnosed and treated as non-Hodgkin lymphoma

... heightened helper T-cell type response at the sites of the disease. Most granuloma-associated lymphocytes produce high levels of tumor necrosis factor (TNF), Interleukin 12, IL-15, IL18 and GM-CSF. The CD4+ lymphocytes and immune effector cells such as macrophages, mast cells, and natural killer cel ...
Lejupielādēt - Dermatologs
Lejupielādēt - Dermatologs

... genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional a ...
Cryotherapy versus Phenol Chemical Peeling for Solar Lentigines: A
Cryotherapy versus Phenol Chemical Peeling for Solar Lentigines: A

... in younger individuals, because of their increased exposure to sun tanning, and the use of artificial sources of ultraviolet light (UV)1. Solar lentigines possibly occur due to melanocytes mutation which results in proliferation and enhanced pigment production in response to UV radiation. Moreover, ...
The HSF MSAB Peer-Reviewed Database
The HSF MSAB Peer-Reviewed Database

... are links to only 17 full text papers available without charge. Patients have reported that they have searched for decades without finding information that could help explain the nature of this complex disease, its morbidity, associated complications and treatments. Physicians and researchers contin ...
A Study of Efficacy of Microdermabrasion in
A Study of Efficacy of Microdermabrasion in

... Scars form at the site of an injury to tissue. In the case of acne, the injury is caused by the body’s inflammatory response to sebum, bacteria and dead cells in the plugged sebaceous follicle.[2] There is considerable variation in scarring between one person and another, indicating that some people ...
Cardiometabolic comorbidities: the fingerprint of psoriasis
Cardiometabolic comorbidities: the fingerprint of psoriasis

... Plaque psoriasis is by far the most common clinical form of the condition (90% of patients with psoriasis) and is characterized by well delineated red and scaly plaques |4|. The extent of involvement is variable, ranging from a few localized plaques at extensor sites to generalized involvement (Fig. ...
Pityrosporum Diagnosis and Management in 6 Female Adolescents With Acne Vulgaris
Pityrosporum Diagnosis and Management in 6 Female Adolescents With Acne Vulgaris

... folliculitis. Perhaps the density of lipids in the pilosebaceous unit of acne-prone individuals leads to a higher concentration of the organism in hair follicles and thus a folliculitis. All of our patients were female, and some other studies also report increased incidence among girls. However, a p ...
Untitled - The Dermatologist
Untitled - The Dermatologist

... reading studies, I’m now a believer that retinol is nearly as effective as tretinoin without the side effects. I ...
Lupus erythematosus panniculitis in children and adolescents
Lupus erythematosus panniculitis in children and adolescents

... lymphocytic vasculitis in the small vessels of the fat lobule, as described in our cases. Importantly, differential diagnosis encompass subcutaneous panniculitis-like T-cell lymphoma, deep morphea, erythema nodosum, erythema induratum of Bazin, post-steroid panniculitis7-8, Weber-Christian disease a ...
Treatment of segmental vitiligo with normal
Treatment of segmental vitiligo with normal

... stimulate re-pigmentation in vitiligoaffected areas has been reported earlier by some authors (18, 23, 24). Pigmentation starts appearing at 4thto 5th week and continues up to 6 months or even longer (25). In this method, although the appearance of pigmentation was delayed when compared to other mod ...
Prediction of atopy via total immunoglobulin E
Prediction of atopy via total immunoglobulin E

... The sex and age distribution according to groups is presented in Table 1. There were no statistically significant differences in average age between the 3 groups (P = 0.109). Clinical and demographical features for all groups are presented in Table 1. There was a history of asthma for 5 patients (5. ...
Treatment of Housewives` Hand Eczema
Treatment of Housewives` Hand Eczema

... exposed to challenging chemicals and environmental conditions. Therefore they are the area most susceptible to skin problems. This term has been used at home and abroad because its incidence is so high among housewives, who have to use their hands frequently during domestic tasks, and in this group ...
Pimecrolimus Cream 1% for Treatment of Vulvar Lichen Simplex Chronicus:
Pimecrolimus Cream 1% for Treatment of Vulvar Lichen Simplex Chronicus:

... there are well-known potential complications associated with the inappropriate use of corticosteroids. These complications include dermal atrophy and stria formation, rebound reactions, hypothalamic-pituitary axis suppression, and secondary infections. To date, there have been no published reports o ...
Cutaneous Mastocytosis: A Case of Case Report
Cutaneous Mastocytosis: A Case of Case Report

... bullae on the bilateral upper and lower extremities and trunk, some surrounded by erythema, multiple crusts, hyperpigmented macules, and hives ...
Kaposi Sarcoma with Visceral Involvement in a HIV
Kaposi Sarcoma with Visceral Involvement in a HIV

... month. In her past history she was healthy until 2 years ago when she noted two plaques on her left foot and a similar one on her right hand. In skin biopsies, there were spindle shaped cells presented with hypervascularity consistent with Kaposi's sarcoma.She had refused any kind of treatment . No ...
Atopy patch test in patients with atopic eczema/dermatitis syndrome
Atopy patch test in patients with atopic eczema/dermatitis syndrome

... Macroscopic results showed erythema and induration in all cases and in 50%  papules,  which  resemble  lesional  skin,  in  both  types  of  application.  All  control  patches  with  vehicle  alone  were  negative,  indicating  that  vehicle  alone  did  not  induce  an  irritant  reaction.  This  ...
Focal Hyperhidrosis - South Devon and Torbay CCG
Focal Hyperhidrosis - South Devon and Torbay CCG

... temperature. It affects around 2-3% of the population, with an average age of onset of 25 years, peaking at 40 years and declining thereafter. Hyperhidrosis can be classified as generalised, or focal (most commonly axillae, palms and soles). Generalised hyperhidrosis can be caused by underlying infe ...
URTICARIA
URTICARIA

... •It is postulated that mast cells sensitized with immunoglobulins (especially IgE) react to an antigen induced by mechanical stimulation of the skin and release their mediators •This reaction is normal but in 5% of normal people this physiological response is sufficiently exaggerated to warrant the ...
J Am Acad Dermatol
J Am Acad Dermatol

...  Since her last visit, the patient has been using her topical treatments as prescribed  After some initial improvement, her rash has become more extensive and now involves her back and abdomen  She is becoming increasingly concerned about the appearance of her skin because she is planning a tropi ...
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Hairy cell leukemia



Hairy cell leukemia is an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes. It is usually classified as a sub-type of chronic lymphoid leukemia. Hairy cell leukemia makes up approximately 2% of all leukemias, with fewer than 2,000 new cases diagnosed annually in North America and Western Europe combined.Hairy cell leukemia was originally described as histiocytic leukemia, malignant reticulosis, or lymphoid myelofibrosis in publications dating back to the 1920s. The disease was formally named leukemic reticuloendotheliosis and its characterization significantly advanced by Bertha Bouroncle and colleagues at The Ohio State University College of Medicine in 1958. Its common name, which was coined in 1966, is derived from the ""hairy"" appearance of the malignant B cells under a microscope.
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