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Feline Plasma Cell Pododermatitis Nicole A. Heinrich DVM DACVD McKeever Dermatology Clinics www.mckeevervetderm.com 952-946-0035 Plasmascellpododermatitisisanuncommonimmune-mediateddiseaseaffecting thepawpadsofcats.Thepathogenesisisunknown,butmaybeahypersensitivity oranautoimmuneprocess.Itischaracterizedbydenseinfiltrationofplasmacells intothepads. Theresultingclinicalsignsareswollenpawpads.Theswellingcanbesubtle initiallyanddramaticinseverecases.Variablescaling,fissuringandevenerosion canbepresentaswell.Thepadsmaydevelopapurplehueandthetoesmayspread inanunusualmannerwhenthecatisbearingweight. Generally,thisisanon-pruriticcondition,althoughcatsmaylickthepawsdueto discomfort.Concurrentstomatitishasbeenreported. Thediagnosisisoftenmadebasedonhistoryandphysicalexam.Askinbiopsy revealsadiffuseinfiltrateofplasmacells.Serumchemistrymayreveal hypergammaglobulinemia. Themaindifferentialdiagnosesinclude:atopicdermatitis,foodallergyand pemphigusfoliaceus.Allergiestendtobemorepruriticthanplasmacell pododermatitis.Pemphigustendstobemorepainfulwiththickercrustsonthe pads.Additionally,theclawfoldstendtoaccumulateacaseous,whitedebrisin pemphigus.Bothcondtionsusuallyfeatureinterdigitalerythemaasopposedto plasmacellpododermatitiswheretheinterdigitalskinisrarelyaffected. Thisconditionisgenerallycontrolled,butnotcured.Catsrequireongoing medicationtokeepthepawscomfortable. Treatmentsthataremostofteneffectiveinclude:doxycyclinesuspensionand modifiedcyclosporine.Doxycyclineisadministeredatadoseof5mg/kgPOq12 hoursfor6to8weeks,thenasneededtocontrolswelling.Oncedailydosingmay bepossible.Modifiedcyclosporine(Atopicaispreferable)isadministeredatadose of5mg-7mg/kgPOq24hoursfor6to8weeks,thenasneededtocontrolswelling. Everyotherdaydosingmaybepossible. Theprognosisisgood.