Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Feline Plasma Cell Pododermatitis
Document related concepts
no text concepts found
Transcript
Feline Plasma Cell Pododermatitis Nicole A. Heinrich DVM DACVD McKeever Dermatology Clinics www.mckeevervetderm.com 952-946-0035 Plasmascellpododermatitisisanuncommonimmune-mediateddiseaseaffecting thepawpadsofcats.Thepathogenesisisunknown,butmaybeahypersensitivity oranautoimmuneprocess.Itischaracterizedbydenseinfiltrationofplasmacells intothepads. Theresultingclinicalsignsareswollenpawpads.Theswellingcanbesubtle initiallyanddramaticinseverecases.Variablescaling,fissuringandevenerosion canbepresentaswell.Thepadsmaydevelopapurplehueandthetoesmayspread inanunusualmannerwhenthecatisbearingweight. Generally,thisisanon-pruriticcondition,althoughcatsmaylickthepawsdueto discomfort.Concurrentstomatitishasbeenreported. Thediagnosisisoftenmadebasedonhistoryandphysicalexam.Askinbiopsy revealsadiffuseinfiltrateofplasmacells.Serumchemistrymayreveal hypergammaglobulinemia. Themaindifferentialdiagnosesinclude:atopicdermatitis,foodallergyand pemphigusfoliaceus.Allergiestendtobemorepruriticthanplasmacell pododermatitis.Pemphigustendstobemorepainfulwiththickercrustsonthe pads.Additionally,theclawfoldstendtoaccumulateacaseous,whitedebrisin pemphigus.Bothcondtionsusuallyfeatureinterdigitalerythemaasopposedto plasmacellpododermatitiswheretheinterdigitalskinisrarelyaffected. Thisconditionisgenerallycontrolled,butnotcured.Catsrequireongoing medicationtokeepthepawscomfortable. Treatmentsthataremostofteneffectiveinclude:doxycyclinesuspensionand modifiedcyclosporine.Doxycyclineisadministeredatadoseof5mg/kgPOq12 hoursfor6to8weeks,thenasneededtocontrolswelling.Oncedailydosingmay bepossible.Modifiedcyclosporine(Atopicaispreferable)isadministeredatadose of5mg-7mg/kgPOq24hoursfor6to8weeks,thenasneededtocontrolswelling. Everyotherdaydosingmaybepossible. Theprognosisisgood.
