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“C” the Difference The Original Patented Formulas by Dr. Mostafa Omar We are delighted to announce an era of the latest topical treatment for Photoprotection and common dermatologic conditions backed by scientific studies. PhytoCeuticals, Inc. is the market leader of antioxidant skin care products established by Dr. Mostafa Omar, the president of PhytoCeuticals and also the inventor of stabilized L-Ascorbic Acid (Vitamin C) in the United States with awarded grants by National Cancer Institute (NCI) grant #1 R43- CA83538-01A1 for “Prevention of UV Photoinjury in Skin by Antioxidants”, NCI Grant #1-R43CA94484-01 for “Photoprotection of Skin by Topical Selenium”, Olive patent # 6,743,499 B2 and Aleoferon patent # 4861761 & National Institute of Health (NIH) since 1995. The formulations once used by Cellex-C, SkinCeuticals, and IS Clinical by Innovative Skincare are now ONLY available through PHTYO-C Skincare. This year, along with the development of formulas on Photoprotection and Prevention of UV Damage we are proud to announce our new SuperHeal O-Live Series and the latest Photoprotection of Skin by Topical Selenium. We also aim to develop and launch the most advanced, effective and safe skin care formulations with natural ingredients, which will be backed by our 15 years of innovative scientific studies, rigorous clinical research and dermatological scientific breakthroughs in targeting different kinds of skin problems, such as Vitiligo, Eczema, Rosacea, Acne, Fungal Infections, Dry skin and etc. Improve skin health and overall appearance by utilizing our PHYTO-C Rx |Skin Care series. www.phyto-ceutical.com Dr. Mostafa Omar, president of PhytoCeuticals Dr. Mostafa Omar is a professor of Pharmacognosy at the University of Rhode Island of Pharmacy who has earned a strong reputation worldwide as a leading expert in the field of antioxidants. He is a chief chemist and principal investigator for NCI (The National Cancer Institute) on photo-aging prevention, and has developed products with grants from both NCI and NIH (The National Institute of Health.) In addition, he is an expert in natural product chemistry, herbal extracts and herbal health care. He is the creator of the world's only liquid creatine. Dr. Omar has been the pioneer and foremost authority on topical Vitamin C (L-Ascorbic Acid) since 1995, when he perfected the only naturally-stable topical Vitamin C on the market. His breakthrough formulations provide unparalleled protection from premature signs of aging caused by environmental damage - mostly caused by sun exposure (UV radiation and free radicals), and have made him well known as the 'Father of Topical LAscorbic Acid'. Once available through Cellex-C, SkinCeuticals and iS Clinical, Dr. Omar's formulations are only available through PHYTO-C Skin Care at PhytoCeuticals, Inc. PHYTO-C Skin Care is an all-natural serum-based medical skin care line that provides unsurpassed results. "C" the difference on your skin! WHAT’S NEW PHYTO-C Rx |Skin Care, uses powerful natural ingredients, however still requires a medical prescription due to its potency in targeting dermatological conditions, such as Acne, Rosacea, Vitiligo, Eczema, Dry Skin, Fungal Infections, etc. This season, PhytoCeuticals demonstrated again a scientific breakthrough for developing Retinol (Vitamin A) and Alpha Tocopherol (Vitamin E) in Aqueous form. Retinol and Alpha Tocopherol are commonly known to be oil-soluble form only. However, Dr. Mostafa Omar stabilized them into water soluble form so that these highly effective ingredients could penetrate faster into the skin and minimize the irritation that would usually be caused by the oil-soluble form which cannot permeate the skin. Retinol 1% This special aqueous form of Retinol (Vitamin A) penetrates into your dermal layer of skin, re-builds the skin tissues, enhances skin texture, and reduces the fine lines and wrinkles. Furthermore, it accelerates exfoliation, and hence clears the clogged pores and minimizes the appearance of pore size. It has been regarded as the core ingredient for Acne treatment, Problem Skin Disorders Treatment and Skin Rejuvenation. Warning: Retinol can result in severe irritation if used without medical supervision. Alpha Tocopherol 1% An aqueous form of Alpha Tocopherol (Vitamin E) is a powerful Antioxidant, which helps neutralize free radicals, also enhances the skin’s water binding abilities, and nourishes the skin and relieves the symptoms of eczema. VITILIGO Cream – Coming Soon “Vitiligo is a common pigmentary disorder of the skin characterized clinically by the appearance of spots or areas of depigmentation and histopathologically by absence of the dendrite melanocytes in the basal area of the epidermis. Trials of treatment by psoralens, khellin, local steroids and others are well documented.”1 However, a clinical study has shown that a trial of treatment by a natural plant mixture was attempted to see the underlying structural or biological changes which occur in the melanocyte during the process of regaining the skin for its normal coloration. Reference: 2 1. “Phytotherapy of Vitiligo, Local Treatment by Combined Aloe Vera Gel and Apple Vingar, A Histochemical and Electron Microscopic Study”, Aly Abdel Fattah, Mostafa M Kamel, Departments of Dermatology, Pathology and Phytochemistry, Ain Shams University and National Organization for Drug Control and Research www.phyto-ceutical.com SuperHeal O-Live by Olive Leaf Extract with Patent# US 6, 743,449 B2 In the O-Live line, we offer more comfort, healing, hydration, radiance, safety and protection to the skin by this patented Olive Leaves Extract formulas. Olive leaf extract is recovered from the leaves of Olive trees species (Olea Europaea), which was first used medicinally in Ancient Egypt. It has been cultivated since prehistoric times, and has been known to provide a variety of benefits in medicinal use, internally and externally. An 1854 article in the Pharmaceutical Journal provided the following simple healing remedy: “A handful of leaves boiled in a quart of water down to half its original volume. A wine glassful was then administered until the fever was cured.” The author believed that a bitter substance in the leaves was the key healing ingredient. Olive leaves are known to contain high levels of secoiridoid glucosides such as Calcium Elenolate, Alpha-Tyrosol and Oleuropein, the “bitter principle” which was determined to be the most powerful natural antioxidant, antibacterial, antiviral and anti-inflammatory extract. Oleuropein and its metabolite hydroxyl tyrosol have powerful antioxidant activity in vivo and in vitro. Research has showed that a liquid extract made directly from fresh olive leaves possess the antioxidant capacity of almost 400 times higher than Vitamin C2, which has gained international attention. In addition, below study shows that Olive Leaf Extract in combination with topical Vitamin C, Vitamin A and Vitamin E provides extraordinary photo protective and antiinflammatory effects on the skin. Figure 1 shows the antioxidant protection factor of various formulations having one or more of the following components: C- Vitamin C, E-Vitamin E, A-Vitamin A, Olive-Olive Leaf Extract. It shows that the combination of Vitamin C, E, A and Olive Leaf Extracts provide the highest antioxidant protection. (US Patent# 6,743,449 B2) Benefits of Olive Leaves Extract: Powerful Antioxidant Anti-bacterial Anti-fungal Anti-inflammatory Anti-viral Immune system booster Ultra gentle and intensely nourishing Relieve the symptoms of Eczema and Rosacea Boost your skin’s radiance and restarts cellular respiration, to curb the formation of wrinkles and fine lines Reference: 2. “Oxygen Radical Absorbance Capacity (ORAC) Report on Olive Leaf Australia's Olive Leaf Extracts”, Dr Stevenson, L, et al., Southern Cross University, 2005 3 NEXT GENEREATION OF ANTIOXIDANT EDUCATION by Dr. Mostafa M. Omar Photoprotection of Skin by Topical Selenium Supported by National Cancer Institute Grant #1-R43-CA94484-01 Principal Investigator: Mostafa M. Omar, Ph.D. Abstract Ultraviolet (UV) radiation causes oxidative damage to skin which can cause skin cancer, alter the behavior of skin cancer (typically making the cancer more aggressive), and/or cause photoaging. Topical selenium compounds may prevent this damage. In an attempt to moderate UV-induced photodamage, we will formulate topical selenium products and test them in pig skin. Formulations – including selenium sulfite, L-selenomethionine, selenotrisulfide, derivatives of lipoic acid and lipoamide – will be tested for percutaneous absorption in pig skin. Those formulations having the best characteristics will be chosen for further study. We will irradiate normal pig skin with UV radiation. We will assess histological changes and quantitate damage by measuring apoptosis, nucleic acid oxidation, and matrix metalloproteinase induction. We will determine the relative protection of topical selenium formulations to inhibit photodamage. Summary Selenium, an essential trace element for health, has been shown to have strong anticancer effects, apparently related to its essential catalytic role in antioxidant enzymes. Topical selenium formulations have been shown to inhibit animal skin tumor formation and protect against photodamage caused by UV light. Supplemental selenium may augment the skin’s antioxidant reservoir and supply added protection to the skin against photocarcinogenesis and photoaging. MEDIA & EVENTS NATURAL VS SYNTHETIC What is the different between Arbutin and Hydroquinone? Arbutin is the Natural HO Active Ingredient O OH O extracted from the Uva OH Ursi plant. It is a HO OH water soluble active Structure of Arbutin ingredient and used for lightening the dark skin by inhibiting the tyrosinase enzyme which is responsible for converting tyrosine amino acid to melanin pigmentation. It is a reversible reaction so Arbutin is no longer being used, the natural skin pigmentation process will work on its own. Hydroquinone is a synthetic ingredient which was used to bleach the pigmentation from skin and it is an irreversible Structure of Hydroquinone reaction, i.e. skin cannot regain its pigmentation again. It is an alcohol soluble ingredient and now Hydroquinone is under FDA regulation which permits the use by doctors only, however, concentration cannot exceed 2% and will soon be banned due to its bad side effects. For more information, please contact us at 1-877-474-9862 or [email protected] or visit www.phyto-ceutical.com.