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CLINICAL STUDY YOUTH INTENSIVE CRÈME CLINICAL STUDY ™ Study performed by BioScreen Testing Services, Inc. RESULTS AND CONCLUSIONS Statistically significant improvements in skin hydration, STUDY OBJECTIVE skin firmness, skin tone, and skin texture occurred with The effectiveness of iS CLINICAL ® YOUTH INTENSIVE use of YOUTH INTENSIVE CRÈME. Biometrics, clinical CRÈME was evaluated for improvement in several grading, and subject questionnaires were all used to age-related parameters in subjects ranging from age evaluate results. Positive results appeared at one day 42 to 68 years. and increased throughout the entire four week time period of the study. Subject questionnaires were STUDY DESIGN extremely positive about the product and these opinions A total of 35 female subjects ranging in age from 42 to became even more positive with increasing time of 68 years completed the study using YOUTH INTENSIVE product use. Subject questionnaire results are shown in CRÈME twice daily for four weeks. There were 17 the final section and objective results are shown in the Caucasian subjects, 13 Hispanic subjects, and 5 African- initial sections. For all results reported below, a American subjects in the study population. The subjects statistically significant improvement in the raw value also uniformly used a standard cleanser, iS CLINICAL was required before results are shown. CLEANSING COMPLEX, and sun protection, INNOVATIVE SKINCARE ® ECLIPSE SPF 50 + . The test product, YOUTH Improvements in every parameter increased steadily with INTENSIVE CRÈME, was used twice daily. time. The raw values obtained via objective instrument measurement showed improvement at the earlier time Parameters of skin hydration, skin firmness, skin tone, periods and increased through week four. For the clinical and skin texture were evaluated using instrument grading performed visually, improvements appeared at measurements, clinical grading, and subject questionnaires. four weeks. Improvements were occurring and detectable by instrumentation as early as one day but SIGNIFICANCE OF STUDY took longer to be obvious visually. Fast results and minimal down time are strongly desired in today’s market. The four-week time period for this ONE DAY RESULTS – Instrument measurements of skin study is considered short, since some of the parameters hydration measured by corneometer improved after one evaluated day of use. Subject opinions are shown in a separate often require several months to show improvement with new product application. An effective section and were very positive. product that gave anti-aging results within this time period should fulfill the high standards and hopes of today’s users. Anti-aging benefits of this product would be verified by improvements in the parameters SKIN HYDRATION (Corneometer) - Day 1 Percent Increase 100% evaluated. 1 i S CLI N I CAL ® 1.888.804.4447 www.isclinical.com All materials contained on this document are protected by United States copyright law. You may not modify, remove, delete, publish, transmit, reproduce or in any way exploit the content of this document, in whole or in part. © 2015 Science of Skincare ™, LLC. All rights reserved. ONE WEEK RESULTS – Instrument measurement of skin SUBJECT EVALUATIONS hydration measured by corneometer and skin firmness measured by cutometer improved after one week of use. 100 Subject opinions are shown in a separate section and 90 were very positive. 100% Percent Increase SKIN FIRMNESS (Cutometer) - Week 1 65.71% Percent Increase FOUR WEEK RESULTS – Instrument measurements of skin Percentage of participants who agreed 80 SKIN HYDRATION (Corneometer) - Week 1 70 60 50 40 30 20 hydration measured by corneometer and skin firmness measured by cutometer improved after four weeks of 10 use. Subject opinions are shown in a separate section 0 and were very positive. I am satisfied My skin tone with the overall and texture results this has improved product provides SKIN HYDRATION (Corneometer) - Week 4 At Day 1 100% Percent Increase My skin looks more firm At Week 1 My skin appears more volumized At Week 4 100 SKIN FIRMNESS (Cutometer) - Week 4 90 77.14% 80 Percentage of participants who agreed Percent Increase SKIN TONE (Clinical Grading) - Week 4 42.86% Percent Increase SKIN TEXTURE (Clinical Grading) - Week 4 25.71% Percent Increase performed via subject questionnaire at one day, one week, and four weeks. Results improved steadily throughout the period of the study. With longer product improvement is expected to continue. 60 50 40 30 20 SUBJECT EVALUATIONS OF PRODUCT – These were use, 70 The questions and responses are recorded in the following 10 0 The appearance of my fine lines and wrinkles has improved At Day 1 My skin appears and feels more hydrated I prefer the feel of this product over my current facial treatment product At Week 1 I would recommend this product to a friend At Week 4 graphs. 2 i S C LI N I CAL ® 1.888.804.4447 www.isclinical.com All materials contained on this document are protected by United States copyright law. You may not modify, remove, delete, publish, transmit, reproduce or in any way exploit the content of this document, in whole or in part. © 2015 Science of Skincare ™, LLC. All rights reserved. ADVERSE EVENTS – There were ZERO ADVERSE REACTIONS to the product reported throughout the 4 WEEK RESULTS - MARIONETTE LINES course of the study. CONCLUSIONS – With use of YOUTH INTENSIVE CRÈME, subjects experienced immediate improvement in several skin parameters beginning at the first day and continuing to improve steadily through the entire four week study period. Measurements performed included instrument measurements, clinical evaluator analyses, and subject evaluations of the product. In each category and for all measurements, each value improved in every successive time frame. These results are shown in the graphs preceeding. Subject opinions of the elegant feel of the product, results on their skin, and desire to continue using the product were very high. At study completion, 87% of all subjects noted that they preferred YOUTH INTENSIVE CRÈME over their current facial treatment product. 97% would recommend the REFERENCES Undine B, Elsner P. Hardware and Measuring Principle: The Cutometer. In the Bioengineering of the Skin – Skin Biomechanics. 2002;91-98. Agache P, Barchon D. Skin Mechanical Function. In the Measuring of the Skin. 2004;429-467. Information and Operating Instructions for the Cutometer MPA 580 and Its Probes. product to a friend. Jamac GB, Serup J. Epidermal Hydration and Skin Mechanics. Arch Derm-Venereol. 1990. 70:245-50. BEFORE AND AFTER PHOTOS Arch. Dermatol. 1992. 128:347-351. 1 DAY RESULTS - PERIORBITAL AREA Br J Dermatol. 1994. 130:167-173. Skin Pharmacol Appl Skin Physiol. 2003. 16:100-7. Skin Res Technol. 2002. 2:112-117. 1 WEEK RESULTS - GLABELLAR AREA 3 i S CLI N I CAL ® 1.888.804.4447 www.isclinical.com All materials contained on this document are protected by United States copyright law. You may not modify, remove, delete, publish, transmit, reproduce or in any way exploit the content of this document, in whole or in part. © 2015 Science of Skincare ™, LLC. All rights reserved.