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CLINICAL STUDY
YOUTH INTENSIVE CRÈME CLINICAL STUDY
™
Study performed by BioScreen Testing Services, Inc.
RESULTS AND CONCLUSIONS
Statistically significant improvements in skin hydration,
STUDY OBJECTIVE
skin firmness, skin tone, and skin texture occurred with
The effectiveness of iS CLINICAL ® YOUTH INTENSIVE
use of YOUTH INTENSIVE CRÈME. Biometrics, clinical
CRÈME was evaluated for improvement in several
grading, and subject questionnaires were all used to
age-related parameters in subjects ranging from age
evaluate results. Positive results appeared at one day
42 to 68 years.
and increased throughout the entire four week time
period of the study. Subject questionnaires were
STUDY DESIGN
extremely positive about the product and these opinions
A total of 35 female subjects ranging in age from 42 to
became even more positive with increasing time of
68 years completed the study using YOUTH INTENSIVE
product use. Subject questionnaire results are shown in
CRÈME twice daily for four weeks. There were 17
the final section and objective results are shown in the
Caucasian subjects, 13 Hispanic subjects, and 5 African-
initial sections. For all results reported below, a
American subjects in the study population. The subjects
statistically significant improvement in the raw value
also uniformly used a standard cleanser, iS CLINICAL
was required before results are shown.
CLEANSING COMPLEX, and sun protection, INNOVATIVE
SKINCARE ® ECLIPSE SPF 50 + . The test product, YOUTH
Improvements in every parameter increased steadily with
INTENSIVE CRÈME, was used twice daily.
time. The raw values obtained via objective instrument
measurement showed improvement at the earlier time
Parameters of skin hydration, skin firmness, skin tone,
periods and increased through week four. For the clinical
and skin texture were evaluated using instrument
grading performed visually, improvements appeared at
measurements, clinical grading, and subject questionnaires.
four
weeks.
Improvements
were
occurring
and
detectable by instrumentation as early as one day but
SIGNIFICANCE OF STUDY
took longer to be obvious visually.
Fast results and minimal down time are strongly desired
in today’s market. The four-week time period for this
ONE DAY RESULTS – Instrument measurements of skin
study is considered short, since some of the parameters
hydration measured by corneometer improved after one
evaluated
day of use. Subject opinions are shown in a separate
often
require
several
months
to
show
improvement with new product application. An effective
section and were very positive.
product that gave anti-aging results within this time
period should fulfill the high standards and hopes of
today’s users. Anti-aging benefits of this product would
be
verified
by
improvements
in
the
parameters
SKIN HYDRATION (Corneometer) - Day 1
Percent Increase
100%
evaluated.
1
i S CLI N I CAL ®
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© 2015 Science of Skincare ™, LLC. All rights reserved.
ONE WEEK RESULTS – Instrument measurement of skin
SUBJECT EVALUATIONS
hydration measured by corneometer and skin firmness
measured by cutometer improved after one week of use.
100
Subject opinions are shown in a separate section and
90
were very positive.
100%
Percent Increase
SKIN FIRMNESS (Cutometer) - Week 1
65.71%
Percent Increase
FOUR WEEK RESULTS – Instrument measurements of skin
Percentage of participants who agreed
80
SKIN HYDRATION (Corneometer) - Week 1
70
60
50
40
30
20
hydration measured by corneometer and skin firmness
measured by cutometer improved after four weeks of
10
use. Subject opinions are shown in a separate section
0
and were very positive.
I am satisfied
My skin tone
with the overall and texture
results this
has improved
product provides
SKIN HYDRATION (Corneometer) - Week 4
At Day 1
100%
Percent Increase
My skin
looks more
firm
At Week 1
My skin
appears more
volumized
At Week 4
100
SKIN FIRMNESS (Cutometer) - Week 4
90
77.14%
80
Percentage of participants who agreed
Percent Increase
SKIN TONE (Clinical Grading) - Week 4
42.86%
Percent Increase
SKIN TEXTURE (Clinical Grading) - Week 4
25.71%
Percent Increase
performed via subject questionnaire at one day, one
week, and four weeks. Results improved steadily
throughout the period of the study. With longer product
improvement
is
expected
to
continue.
60
50
40
30
20
SUBJECT EVALUATIONS OF PRODUCT – These were
use,
70
The
questions and responses are recorded in the following
10
0
The appearance
of my fine lines
and wrinkles
has improved
At Day 1
My skin
appears and
feels more
hydrated
I prefer the feel
of this product
over my current
facial treatment
product
At Week 1
I would
recommend
this product
to a friend
At Week 4
graphs.
2
i S C LI N I CAL ®
1.888.804.4447 www.isclinical.com
All materials contained on this document are protected by United States copyright law. You may not modify, remove, delete, publish, transmit, reproduce or in any way exploit the content of this document, in whole or in part.
© 2015 Science of Skincare ™, LLC. All rights reserved.
ADVERSE
EVENTS
–
There
were
ZERO
ADVERSE
REACTIONS to the product reported throughout the
4 WEEK RESULTS - MARIONETTE LINES
course of the study.
CONCLUSIONS – With use of YOUTH INTENSIVE CRÈME,
subjects experienced immediate improvement in several
skin
parameters
beginning
at
the
first
day
and
continuing to improve steadily through the entire four
week study period. Measurements performed included
instrument measurements, clinical evaluator analyses,
and subject evaluations of the product. In each category
and for all measurements, each value improved in every
successive time frame. These results are shown in the
graphs preceeding. Subject opinions of the elegant feel
of the product, results on their skin, and desire to
continue using the product were very high. At study
completion, 87% of all subjects noted that they
preferred YOUTH INTENSIVE CRÈME over their current
facial treatment product. 97% would recommend the
REFERENCES
Undine B, Elsner P. Hardware and Measuring Principle: The Cutometer.
In the Bioengineering of the Skin – Skin Biomechanics. 2002;91-98.
Agache P, Barchon D. Skin Mechanical Function. In the Measuring of the
Skin. 2004;429-467.
Information and Operating Instructions for the Cutometer MPA 580 and
Its Probes.
product to a friend.
Jamac GB, Serup J. Epidermal Hydration and Skin Mechanics. Arch
Derm-Venereol. 1990. 70:245-50.
BEFORE AND AFTER PHOTOS
Arch. Dermatol. 1992. 128:347-351.
1 DAY RESULTS - PERIORBITAL AREA
Br J Dermatol. 1994. 130:167-173.
Skin Pharmacol Appl Skin Physiol. 2003. 16:100-7.
Skin Res Technol. 2002. 2:112-117.
1 WEEK RESULTS - GLABELLAR AREA
3
i S CLI N I CAL ®
1.888.804.4447 www.isclinical.com
All materials contained on this document are protected by United States copyright law. You may not modify, remove, delete, publish, transmit, reproduce or in any way exploit the content of this document, in whole or in part.
© 2015 Science of Skincare ™, LLC. All rights reserved.