Download Bioactive One-Dimensional Nanostructures Samuel I. Stupp

Bioactive One-Dimensional Nanostructures
Samuel I. Stupp
Department of Chemistry, Department of Materials Science and
Engineering, and Department of Medicine
Institute for BioNanotechnology in Medicine
Northwestern University
Our laboratory has developed a broad class of molecules known as peptide
amphiphiles programmed to self-assemble into high aspect ratio one-dimensional
nanostructures.1-5 Filaments formed with these molecules form through
hydrogen bonding as well as hydration and hydrophobic forces leading to
nanostructures that display on their surfaces biological signals. Some of these
supramolecular aggregates can undergo crystallization at long range based on
repulsive forces, organize with orientational order over macroscopic scales, and
form hierarchical structures with oppositely charged macromolecules6. Bioactive
examples of these nanostructures crafted to signal cells have great potential in
advanced therapies for regenerative medicine and cancer. The supramolecular
chemistry of such nanostructures should allow them to interact specifically with
cell receptors or intracellular targets. This lecture will describe the development
of the self-assembly code that led to these bioactive nanostructures and also
illustrate the use of these systems in the regeneration of neurons, the growth of
blood vessels, bone and cartilage regeneration, among other therapeutic targets
for advanced medicine.
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