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Instructions for carrying out statistical procedures and tests using Minitab These instructions are closely linked to the author’s book: Essential Statistics for the Pharmaceutical Sciences John Wiley & Sons Ltd http://eu.wiley.com For all references to chapters or tables, see the above book. Using Minitab to perform a one-way analysis of variance Using Minitab to perform a one-way analysis of variance Example: Table 14.1 Effect of catalyst on yield (Percentage of theoretical maximum) Use the XL file ‘Data for Table 14.1 (Minitab version)’ from the web site. Label one column to hold the yields (‘Yield’) and another (‘Catalyst’) to hold the labels that will indicate which group each yield belongs to. Enter all the percentage yields into the relevant column and put suitable labels into the other column. The worksheet should then look like this: Follow the menus Stat / ANOVA / One-way… In the top box, select ‘Response data are in one column for all factor levels’. In the box labelled ‘Response:’, enter the name of the column containing the data to be analysed (‘Yield’). In the box labelled ‘Factor:’, enter the name of the column containing the labels for the groups (‘Catalyst’). OK. The output will be as on next page: One-way ANOVA: Yield versus Catalyst Method Null hypothesis Alternative hypothesis Significance level All means are equal At least one mean is different α = 0.05 Equal variances were assumed for the analysis. Factor Information Factor Catalyst Levels 5 Values Ir, Pd, Pd/Ir, Pt, Rh Analysis of Variance Source Catalyst Error Total DF 4 20 24 Adj SS 148.06 19.30 167.36 Adj MS 37.0156 0.9648 F-Value 38.37 P-Value 0.000 Model Summary S 0.982242 R-sq 88.47% R-sq(adj) 86.16% R-sq(pred) 81.98% Means Catalyst Ir Pd Pd/Ir Pt Rh N 5 5 5 5 5 Mean 11.920 17.420 13.700 10.740 11.180 StDev 0.978 1.335 0.430 0.688 1.195 95% (11.004, (16.504, (12.784, ( 9.824, (10.264, CI 12.836) 18.336) 14.616) 11.656) 12.096) Pooled StDev = 0.982242 Minitab will also produce this Figure: Interval Plot of Yield vs Catalyst 95% CI for the Mean 19 18 17 Yield 16 15 14 13 12 11 10 Ir Pd Pd/Ir Catalyst The pooled standard deviation was used to calculate the intervals. Pt Rh The P value is reported as 0.000 (Which should be reported as ‘<0.001’) and is clearly significant. This means that at least one of the catalysts differs from one of the others. The problem is deciding which differs from which. The figure, gives a visual impression, but can never be definitive. Palladium is pretty clearly superior to all others but among the remainder, the situation is unclear. For a definitive analysis, you will need to add on either a Tukey’s or a Dunnett’s test. Return to main menu