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diagnostic tree Janice Dye, DVM, MS, PhD, Diplomate ACVIM (Small Animal Internal Medicine) Cough in Cats NO Perform thoracic examination and auscultation, tracheal palpation, thoracic radiography, MDB Adventitial lung sounds Normal or reduced bronchovesicular sounds Tracheobronchial cough Nonspecific cough Radiographic evidence of bronchial, mixed bronchointerstitial, or bronchoalveolar pattern Serology, fecal examinations, BAL or fine-needle lung aspiration (cytology/culture), thoracic CT Bronchoscopy and/or airway sampling (cytology/culture), heartworm antigen & antibody • Pneumonia/pneumonitis - Viral (FHV-1, FCV) - Parasitic (Dirofilaria, other) - Mycotic - Bacterial: Primary (Bordetella) or secondary (dental disease) - Protozoal (Toxoplasma) - Atopy-related (?) • Pleuritis or pleural space disease (FIP, pleural effusions) • Interstitial lung disease (IPF, other subtypes) • Neoplasia • Pulmonary edema—if severe, CHF, fluid overload • Extrapulmonary chronic inflammatory conditions (rhinitis, otitis, GERD) YES Article Title Laryngopharyngeal cough Perform MDB, cranial & oral examination, skull/neck radiography or CT, rhinoscopy or laryngoscopy • Rhinitis/sinusitis - Infections - Inflammatory (idiopathic) - Atopy-related (?) - Neoplasia • Laryngitis - Infectious - Inflammatory - Postnasal drip (?) - Injury (prior intubation) - Irritant exposure (noxious fumes/gases, particles or dust, smoke inhalation, ETS, litter) • Laryngeal or nasopharyngeal mass, polyp, stenosis, or foreign material (hair, food, medication) • Comorbid conditions - Megaesophagus - Laryngeal paralysis • • • • • • Tracheitis/bronchitis (rule-outs similar to laryngitis) - Infectious (viral) - Inflammatory (feline asthma) - Atopy/allergy-related - HARD - Idiopathic - Irritant exposure - Foreign material - Postnasal drip (?) • Airway obstruction • Airway mucus, debris • Airway fluid or hemorrhage • Airway collapse • Airway compression • Comorbid conditions - Megaesophagus - Laryngeal paralysis Article archived on www.cliniciansbrief.com Cats have a well developed cough reflex. Coughing dispels mucus and inhaled substances from the lower airways. Coughing is not pathognomonic for a specific diagnosis. It often occurs intermittently, with or without wheezing or respiratory distress. Alternatively, it can occur with sneezing/nasal discharge, noisy or stertorous breathing, retching/gagging, or even vomiting. Chronic cough is frequently related to development of airway inflammation, airway obstruction, and mucous hypersecretory states. In cats, cough is commonly observed with bronchial or asthma-like disease; it is variable in parenchymal or pleural space disorders; and is uncommon in cardiac disease alone. However, concurrent pulmonary and cardiac disease may occur. Posttussive vomiting may be a result of air-induced distension of the stomach. Diagnosis Investigation Result BAL = bronchoalveolar lavage; CHF = congestive heart failure; CT = computed tomography; ETS = environmental tobacco smoke; FCV = feline coronavirus; FHV-1 = feline herpervirus type 1; FIP = feline infectious peritonitis; GERD = gastrointestinal reflux disease; HARD = heartworm-associated respiratory disease; IPF = idiopathic pulmonary fibrosis; MDB = minimum database; (?) = analogous to human condition d i a g n o s t i c t re e . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . N AV C c l i n i c i a n’s b r i e f . j u l y . 2 0 0 8 . . . . . 1 7 R E S P I R ATO RY M E D I C I N E Author Sneezing/nasal discharge? Noisy (stertorous) breathing? Retching or gagging? Altered vocalization?