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Curriculum Vitae Ebo Derk de Muinck ADDRESS: Office: Department of Medical and Health Sciences, Division of Cardiovascular Medicine Linköping University SE-581 85 LINKÖPING Sweden Home: Säby Roxvik SE-58599 LINKÖPING Sweden Tel. office: --46-13-222112 Tel. hospital: --46-13-220000, pager no: 2112 Fax: --46-13-145929 [email protected] Tel. home: --46-13-58210 Tel. mobile: --46-730759843 DATE AND PLACE OF BIRTH: February 15, 1957, Rotterdam, The Netherlands VISA STATUS: E.U. Resident EDUCATION: DATE INSTITUTION DEGREE July 14, 1983 Rijksuniversiteit Groningen, Faculteit der Medische Wetenschappen (University of Groningen, Faculty of Medical Sciences) M.D. POSTDOCTORAL TRAINING: DATE SPECIALTY INSTITUTION May 25, 1994 Ph.D. Rijksuniversiteit Groningen, Faculteit der Medische Wetenschappen (University of Groningen, Faculty of Medical Sciences) Thesis Title: Distal Coronary Hemoperfusion during Percutaneous Transluminal Coronary Angioplasty June 1, 1989 Cardiology Rijksuniversiteit Groningen, Faculteit der Medische Wetenschappen (University of Groningen, Faculty of Medical Sciences) June 1988 – June 1989 Fellowship in Interventional Cardiology Universitair Medisch Centrum Groningen (Groningen University Hospital) Sept. 1985 – June 1988 Residencies in: Clinical Cardiology, Universitair Medisch Centrum Groningen Coronary Care, Cardiothoracic Surgery, (Groningen University Hospital) Echocardiography, Cardiac Exercise Testing, Nuclear Cardiology, Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 2 Consultations to General Surgery, Vascular Surgery and Internal Medicine, Diagnostic Coronary Angiography, Heart Transplantation Sept. 1984 – Sept. 1985 Research Rotation Universitair Medisch Centrum Groningen (Groningen University Hospital) and Martini Ziekenhuis Groningen (Martini Hospital Groningen, affiliated with Groningen University Hospital) Sept. 1983 – Sept. 1984 Residencies in: Internal Medicine (Endocrinology and Heamtology), Clinical Cardiology Medisch Spectrum Twente (‘Medical Spectrum Twente’, affiliated with Groningen University Hospital) LICENSURE AND CERTIFICATION: DATE LICENSURE/CERTIFICATION July 14, 1983 M.D., The Netherlands’ Ministry of Health June 19, 1989 Cardiologist, The Netherlands’ Royal Society of Medicine April 1, 2009 Educational Commission for Foreign Medical Graduates (ECFMG) ACADEMIC APPOINTMENTS: DATE ACADEMIC TITLE INSTITUTION Mar. 15-2010 Professor of Vascular Biology Linköping University Mar. 15-2010 Associate Professor of Vascular Biology Center for Medical Imaging science and Visualization, Linköping University Nov. 1, 2009 Associate Professor of Cardiovascular Medicine Center for Medical Imaging science and Visualization, Linköping University Sept. 1, 2009 onward Associate Professor of Cardiovascular Medicine Linköping University July 1, 2007 – Sept. 1, 2009 Associate Professor of Medicine/Physiology Dartmouth Medical School May 4 – May 29, Visiting Professor, Department of Cardiology St. Paul’s Hospital, Vancouver, B.C, 2009 Canada Sept. 2002-2007 Assistant Professor of Medicine/Physiology Dartmouth Medical School July 2001 – Sept. 2002 Visiting Scientist, Department of Medicine, Dartmouth Medical School Section of Cardiology Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 3 April 1995 – Sept. 2002 Assistant Professor, Cardiovascular Research University of Maastricht, Faculty of Institute (CARIM), Maastricht, The Medical Sciences Netherlands. HOSPITAL APPOINTMENTS: DATE HOSPITAL TITLE INSTITUTION Sept. 1, 2009 onward Staff Cardiologist, ‘Överläkara’ Linköping’s University Hospital, Sweden April 1995 – Sept. 2002 Staff Interventional Cardiologist Academisch Ziekenhuis Maastricht (Maastricht University Hospital) June 1989 – April 1995 Staff Interventional Cardiologist Universitair Medisch Centrum Groningen (Groningen University Hospital) OTHER PROFESSIONAL POSITIONS: DATE POSITION TITLE INSTITUTION/ORGANIZATION March, 2010 Member Scientific Advisory Board Center for Medical Imaging science and Visualization, Linköping University February, 2010 Clinical Co-Director Integrative Regenerative Medicine Institute (IGEN), Linköping University, Sweden April, 2009 Scientific Founder Celdara Medical, LLC 2007-2008 Scientific Director Pre-Clinical Research at the Dartmouth Medical School Angiogenesis Research Center Sept. 2002-2007 Director Pre-Clinical Research at the Angiogenesis Research Center Dartmouth Medical School 1999 – July 2001 Consultant regarding coronary intervention Medtronic Vascular April 1995 – July 2001 Program Director Cardiovascular Research Institute Maastricht (CARIM) Research Line III ‘Vascular Biology’ Rijksuniversiteit Maastricht, Faculteit der Medische Wetenschappen (University of Maastricht, Faculty of Medical Sciences) June 1989 – April 1995 Consultant to the Department of Biomedical Engineering Rijksuniversiteit Groningen, Faculteit der Medische Wetenschappen (University of Groningen, Faculty of Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 4 Medical Sciences) June 1989 1991 Coordinator of the joint Heart Transplant Program of the University Hospitals of Groningen and Utrecht Universitair Medisch Centrum Groningen (Groningen University Hospital) Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 5 COMMITTEE ASSIGNMENTS: Assignments since Dartmouth College appointment in August 2002: National/International: YEAR COMMITTEE ROLE INSTITUTION 2007 2007 Study Section Study Section ad hoc project reviewer ad hoc project reviewer 2005 onward Israel Science Foundation Research Foundation Flanders-Belgium American Heart Association Committee on abstract reviewer Scientific Sessions Program Study Section ad hoc project reviewer NIH/NHLBI Atherosclerosis and Inflammation of the Cardiovascular System Study Section ad hoc program project reviewer NIH/NHLBI ‘Inflammation and Repair in Cardiac Ischemia-Reperfusion’ Study Section ad hoc program project reviewer NIH/NHLBI ‘Specialized Centers for Cell Based Therapy’ Study Section ad hoc grant application reviewer Charles H. Hood Foundation Study Section ad hoc grant application reviewer Research Foundation – Flanders 2005 2005 2005 2005 2005 2005 onward Study Section grant application reviewer The Netherlands’ Organization for Health Research and Development Netherlands’ Heart Foundation 2002 onward Study Section grant application reviewer YEAR COMMITTEE ROLE INSTITUTION 2003 - 2006 Study Section grant application reviewer Northeast Affiliate of the American Heart Association Regional: Institutional: YEAR COMMITTEE ROLE INSTITUTION 2010 onward Core Facility Board member Faculty of Health Sciences, Linköping University 2006 onward Department of Physiology Seminar Committee member Dartmouth Medical School Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 6 Everett Koop Research Building Imaging Planning Committee member Dartmouth Medical School 2005 onward American Cancer Society Institutional Research Grant Review Committee grant application reviewer American Cancer Society 2004 - 2006 IACUC member Dartmouth Medical School 2003 onward Department of Physiology Graduate Student Committee member Dartmouth Medical School 2003 onward Thesis Committee Justin Gaudet (Biochemistry) member Dartmouth Medical School 2003 - 2006 Thesis Committee Laura Emond (Physiology) member Dartmouth Medical School MEMBERSHIP, OFFICE & COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES: YEAR SOCIETY ROLE 1996 onward American Heart Association Council on Clinical Cardiology member American Heart Association Council on Atherosclerosis, member Thrombosis and Vascular Biology 1997 onward American Association for the Advancement of Science member 2000 onward North American Vascular Biology Organization member 2003 - 2006 American Heart Association, Interdisciplinary Working member Group on Functional Genomics and Translational Biology 2006 - 2008 International Society for Molecular Imaging member EDITORIAL BOARD: DATE ROLE BOARD NAME January 1, 2010, onward Board Member Atherosclerosis, Editorial Board July 1, 2007 – July 1, 2009 Board Member European Heart Journal, International Editorial Board Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 7 AWARDS AND HONORS: DATE AWARD NAME 2005 U.S. Permanent Residency, Outstanding Investigator Track 2002 Pfizer/ACCF Visiting Professorship Program in Cardiovascular Medicine 2002 2001 Interuniversity Cardiology Institute of the Netherlands (I.C.I.N.), fellowship in support of a year as visiting scientist at the Angiogenesis Research Center, Dartmouth Medical School, Hanover NH. 2000 Gordon Research Conference Vascular Biology, Plymouth NH, U.S.A., July 2000: Poster prize: Conserved flow-mediated arterial remodeling despite impaired nitricoxide dependent vasodilation in atherosclerotic mice. 1994 First Conference on Technology and Health Care, Stuttgart, Germany, June 1994: Poster prize: Active coronary hemoperfusion provides protection against ischemia during percutaneous transluminal coronary angioplasty. JOURNAL REFEREE ACTIVITIES: Reviews since Dartmouth College appointment in August 2002: American Journal of Physiology: Heart and Circulation Physiology American Journal of Cardiology Antioxidants and Redox Signaling Arteriosclerosis Thrombosis and Vascular Biology Atherosclerosis Cardiovascular Research Catheterization and Cardiovascular Interventions Circulation Circulation Research European Heart J Eur J Clin Investigation Haemostasis J Mol Cell Cardiol J Vasc Research Netherlands’s Journal of Medicine OTHER ACTIVITIES Invited visiting professors Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 8 Name Home Institution (outside institutions only) Date of visit Prof. J.C. Leiter Department of Physiology, Dartmouth Medical School, Hanover, NH, USA 6 months total between 2010 2012 Name Home Institution (outside institutions only) Date of visit Prof. D. J. Stewart Ottawa Hospital Research Institute, Ottawa, Ontario, Canada 05-26-2010 – 05-28-2010 Prof. M. Amiji Nanomedicine Education and Research Consortium, Northeastern University, Boston, MA, USA 12-18-2007 Prof. J.R. Lindner Department of Cardiology, Oregon Health and Science University, Portland, OR, USA 11-28-2007 Dr. W. Liu Laboratory of Diagnostic Radiology Research/Philips Medical Systems, National Institutes of Health, Bethesda, MD, USA 09-17-2007 – 09-18-2007 Prof. P. Doevendans Department of Cardiology, Utrecht University Hospital, the Netherlands 11-17-2005 Prof. J. Tijssen Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands 03-03-2005 – 03-05-2005 Dr. R. de Winter Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands 03-03-2005 – 03-05-2005 Prof. P. Carmeliet Center for Transgene Technology & Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium 10-06-2004 Prof. M. Krieger Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA 11-13-2003 Hosted speakers Student grant applications mentored and edited (only awarded grants are mentioned) Recipient Grant Award date Dmitri Baklanov Vascular Biology Working Group Cardiovascular Medicine Fellow Research Award 10-22-2002 Extension of Vascular Biology Working Group Cardiovascular Medicine Fellow Research Award 10-09-2003 S.M. Tenney Medical Student Fellowship Grant, American Heart Association, Northeast Affiliate Predoctoral Fellowship Grant 03-29-2006 05-24-2006 Theodore You Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 9 Robert McGarr Albert J. Ryan fellowship 05-15-2008 Meagan Tibbo Howard Hughes Medical Institute, undergraduate research fellowship 05-19-2008 Kareem Halim Howard Hughes Medical Institute, undergraduate research fellowship 05-19-2008 Ming H. Lee Howard Hughes Medical Institute, undergraduate research fellowship 05-19-2008 Workshop organizer: leader/director University of New Hampshire/Dartmouth Nanotechnology Initiative, the Inn at Marshland Farm, Quechee, VT 04-03-2006 Workshop organizer: co-organizer Workshop on Atherosclerosis and Molecular Imaging CMIV (Center for Medical Imaging Science and Vislualization), Linköping’s University, Linköping, Sweden 12-16- 2009 MAJOR RESEARCH INTERESTS: My laboratory is a translational lab. with a focus on understanding and measuring the impact of CD13/APN as announced by molecular imaging on neo-vascularization, ischemic wound healing, perfusion, oxygenation and function of the heart. PATENT ‘Modification of ischemic wound healing and other inflammatory responses through temporary depletion and/or functional modification of dendritic cells’ U.S. provisional application no: 61/112375 RESEARCH FUNDING: Previous NHLBI (R01 HL078622). (P.I.: de Muinck) Structure/Function of Neovessels Imaged with NGR Peptide Annual Direct Costs: $ 250,000 9/22/04 – 8/31/08 Philips Electronics North America Corp. (P.I.: de Muinck) Multimodal Imaging of Neo-Vessels Annual Direct Costs: $150,650 9/1/05-2/1/08 35% NHLBI (1 RO1 HL 69442-01) (Shapiro) Subcontract PI: de Muinck 6/1/02-6/1/06 25% 35% Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 10 CD154-CD13 Pathway in Inflammation Driven Angiogenesis Subcontract Annual Direct Costs $100,000 Percardia, Inc. (P.I.: de Muinck) 4/1/02-3/31/06 20% Percutaneous ventricle-to-coronary bypass (VPASS) A novel nonsurgical method for myocardial perfusion of ischemic heart disease Annual Direct Costs: $195,821 Boston Scientific (P.I.: de Muinck) 3/18/06-3/17/06 3% Accuracy of Transendocardial Catheter Targeting and Description of Injectate Distribution Patterns in Porcine Model of Acute Myocardial Infarction: The Insights from 3D Echocardiography Annual Direct costs: $55,880 Ension, Incorporated (P.I.: de Muinck) Left Atrial Appendage Isolation Device to Reduce Stroke Annual Direct costs: $16,850 3/1/04-2/28/06 2% Netherlands’s Heart Foundation (NHS 2001.047) (P.I.: de Muinck) 6/1/02-6/1/05 Enhancement of Myocardial Angiogenesis through Targeting of CD13/APN, a Novel Angiogenic Target and Regulator NMT Medical, Inc. (P.I.: de Muinck) Pilot Study with Prototype PFO Closure Device Annual Direct Costs: $21,223 5/10/05-12/31/05 2% Medtronic Bio-Medicus, Inc. (P.I.: de Muinck) Filterwire Pilot Study Annual Direct Costs: $11,244 6/13/05-9/30/05 2% Boston Scientific (Steiner) 3/21/05-9/21/05 Non-GLP Feasibility Study of the Sensor Tip / Sensor Needle Stiletto Injection Catheter Annual Direct costs: $4,780 2% P50 HL63609 NHLBI (sub BIDMC) (Simons) Endothelial Cell Signaling and Cardiac Angiogenesis Annual Direct Costs: $229,504 4/1/02-3/31/05 10% NHLBI (SCOR P50 HL 63609) (Simons) Syndecan signaling in angiogenesis Annual Direct Costs $229,504 4/1/02-4/1/05 10% Bristol-Meyers Squibb (Pearlman) Assessment of Arterial Wall Imaging with an RP 845 Analog Annual Direct Costs $10,645 9/8/05-11/8/05 2% Cordis Corp. (Simons) 10/25/02-10/31/04 20% Preclinical Evaluation of Angiogenesis/Tissue Engineering prototype formulations and device(s) for treatment of Ischemic Heart Disease and Congestive Heart Failure Annual Direct Costs: $426,234 Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 11 Eli Lilly and Company (Simons) Service Laboratory Agreement Annual Direct Costs: $225,000 12/1/02-11/30/03 20% Guidant (Simons) Evaluation of Myocardial Delivery in Pigs Annual Direct Costs: $180,898 9/30/02-9/29/03 10% NMT Medical Inc. (P.I.: de Muinck) A Novel Bioresorbable Septal Occlunder Annual Direct Costs: $104,000 4/1/05-12/2/09 30% 5R01HL056803 NHLBI (Maulik) Subcontract PI: de Muinck Subcontract title: Angiogenesis in Disease Model Annual Direct Costs of subcontract: $76,888 12/1/07-8/1/09 20% 5R01AG023590-04 NHLBI (Shworak) 3OST1 Deficiency and Cardiovascular Disease Annual Direct Costs: $160,000 2/15/05-9/1/09 10% Departmental funds, Department of Medicine, Section of Cardiology 9/1/2008-9/1/09 40% Present: Linköping University start-up funds: Salary (100%) for research assistant professor Annual Direct Costs: $ 61,505 Salary (100%) for post-doctoral candidate Annual Direct Costs: $ 50,317 Bench fee Annual Direct Costs: $ 139,762 4/1/10-4/1/14 4/1/10-4/1/14 4/1/10-4/1/13 FORSS (P.I.: de Muinck) Prevention in Periperal Arterial Disease (PREPAID) Annual Direct Costs: $ 27,895 1/1/10-1/1/11 1R43HL097464-01 SBIR (P.I.: de Muinck) Myocardial Infarction Therapeutics Annual Direct Costs: $ 132,901 8/1/09-7/31/10 Departmental funds, Department of Physiology, Dartmouth Medical School Stipend for one graduate student 9/1/08-04/31/10 TEACHING EXPERIENCE/CURRENT TEACHING RESPONSIBILITIES: Teaching activities at Linköping’s University September 2009 - onward: 25% Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 12 Fellows and Students: - Medical Bioscience Master students: 2010: S. Basnet: 30 credit-point project: Dendritic Cells in Acute Myocardial Infarction 2010: S. Koppal: 15 credit-point project: Dendritic Cells in Atherosclerotic Plaque Teaching activities at Dartmouth Medical School August 2002 - September 2009: Medical School - Cardiovascular Physiology in Medical Physiology 110 - Pharmacology small group (2nd year med. students) - Advanced Medical Sciences ( 4th year med. students) - Graduate Program in Experimental and Molecular Medicine: Advanced Systems Physiology (PEMM 271) Thayer School of Engineering - Cardiovascular Imaging (undergraduate level, ENGS 10) Course Director: - Advanced Cardiovascular Physiology (graduate level) Fellows and Students: - Cardiology fellows: 2002 – 2006: D. Baklanov, projects: Cardiac MRI of iron labeled vascular smooth muscle cells, transplanted into the heart after myocardial infarction in pigs Comparison of retrograde coronary venous infusion versus direct intramyocardial injection for delivery of therapeutics 3D echocardiography guided intramyocardial injections 2003 – 2006: F. Redican, projects: Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries Assessment of murine cardiac hemodynamics combined echocardiography and pressurevolume loop registration - Graduate students: 1995 – 2001: E. Lutgens (primary thesis advisor): Atherosclerosis, an Inflammatory Disease. Graduated ‘cum laude’. 1997 – 2002: H. Schulten: (primary thesis advisor): Nitric Oxide in Arterial Remodeling. 2002 – 2003: C. Elinsky (primary thesis advisor): Identification of CD13/APN in Atherosclerotic Plaque Angiogenesis leading to Plaque Rupture 2006 - 2008: R. McGarr 2008 Albert J. Ryan Fellowship recipient (primary thesis advisor): Vessel Stabilization during Angiogenesis through CD13/Aminopeptidase N Mediated Cleavage of Bradykinin and Kaladin 2006 onward: D. Pruthi 2009 Albert J. Ryan Fellowship recipient (primary thesis advisor): Vascular Leukocytes in the Healing Infarct Wound Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 13 2008: M. Bilodeau (rotation) 2006: R. McGarr (rotation) 2006: D. Pruthi (rotation) 2006: J Qin (rotation) 2005: W. Donnely (rotation) 2005: J. Qin (rotation) 2004: S. Richardson (rotation) 2003: L. Emond (rotation) Medical School students: 2006-2007: T. You Marsh Tenny Fellowship and AHA Northeast Affiliate Predoctoral Fellowship recipient: Identification of Stage of Bloodvessel Development Annonced by CD13/APN expression on Endothelial Cells 2005 – 2007: V. Popov: Optimization of NGR Peptide Sequence to Enhance CD13/APN Binding - Undergraduate students: 2009: R. Feder (rotation) 2009: M. Tibbo Howard Hughes Medical Institute Fellow 2008 – 2009: K. Halim Howard Hughes Medical Institute Fellow 2008 – 2009: M.H. Lee Howard Hughes Medical Institute Fellow 2008: J. Reibel (rotation) 2008: R. Feder (rotation) 2008: H Wang (rotation) 2007: L. Clarkson (rotation) 2005: S. Perry (rotation) 2005: A. Sjogren (rotation) 2004: S. Perry (rotation) 2004: C. Palac (rotation) 2004: F.E. McCarthy (rotation) 2003: A. Niles (rotation) Regional Fellows: 2005: Jun Yu, home institution: Department of Pharmacology, Yale University Medical Center, New Haven, CT, P.I. William Sessa. Purpose of training: learn arterial angiography in the mouse hind limb. International Fellows: 2008-2009: D. Lipman, home institution: Radboud University Medical Centre, Nijmegen, The Netherlands. Purpose of training: introduction to vascular biology. 2006: R. van der Nagel, home institution: Hubrecht Laboratory, Utrecht, The Netherlands, P.I. Leon de Windt. Purpose of training: learn mouse echocardiography Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 14 2005: A. Hirsch, home institution: Academic Medical Center, Amsterdam, The Netherlands, P.I. R. de Winter. Purpose of training: learn mouse cardiac ischemia-reperfusion model International Course 2002: Graduate course ‘Vascular Biology’ Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands INVITED PRESENTATIONS: - 2010: ‘Forskning i Framkant’ seminar, Institute for Medicine and Health, Linköping’s University, March 11, Linköping, Sweden Life Science Seminar, Institute for Clinical and Experimental Medicine, Linköping’s University, February 4, Linköping, Sweden Celdara Medical, LLC, board meeting, January 22, Lebanon, NH, USA - 2009: CMIV board meeting, December 14, Linköping, Sweden IMH-LiTH ‘Julbord’ meeting, December 8, Linköping, Sweden IMH-full-day meeting, November 5, Linköping, Sweden CMIV post-graduate course, September 16 – 17, Kolmården, Sweden Department of Cardiology, Linköping University Hospital, June 10, Linköping, Sweden Department of Pharmacology & Therapeutics, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, May 26, Vancouver, BC, Canada Department of Cardiology, St. Paul’s Hospital, May 13, Vancouver BC, Canada NIH Cardiovascular Imaging Symposium, April 30 – May 1, National Institutes of Health, Bethesda, MD Center for Molecular Medicine, April 24, Karolinska Institute, Stockholm, Sweden. Faculty of Health Sciences, Linköping University, April 22, Linköping, Sweden Medical School Duluth, March 30 – April 1, Duluth, MN - 2008: Heart and Lung Institute at St Paul’s Hospital, Dec.18, 2008, Vancouver, BC, Canada James Hogg iCAPTURE Centre at St. Pauls’ Hospital, Dec. 17, 2008, Vancouver, BC, Canada Regional Cardiology Meeting, Nov. 25, 2008, Roermond, The Netherlands Department of Medicine, University Hospital Galway, Nov. 21, 2008, Galway, Ireland REMEDI, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Nov. 20, 2008, Galway, Ireland Department of Cardiology, Vancouver General Hospital, University of British Columbia, Sept. 15, 2008, Vancouver, BC, CA Department of Cardiology, University Hospital Haugeland, February 15, 2008, Bergen, N Department of Experimental Medical Science, Faculty of Medicine, Lund University, February 13, 2008, Lund, SE Department of Pharmaceutical Sciences, Northeastern University, January 17, 2008, Boston, MA - 2007: Eight Annual Dartmouth Nanomaterials Symposium, Thayer School of Engineering, Dartmouth College, October 27, 2007, Hanover, NH Boehringer Ingelheim Pharmaceuticals Inc., September 14, 2007, Ridgefield, CT G.E., Global Research Center, June 27, 2007, Niskayuna, NY Bentley Pharmaceuticals, February 23, 2007, Exeter, NH Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 15 - - - - - DSM Biomedical, February 15, 2007, Geleen, NL Department of Cardiology, University Hospital Groningen, December 14, 2007, Groningen, NL 2006: NMT Medical Inc. private breakfast meeting, October 22, 2006, Washington DC Edelman lab., Massachusetts Institute of Technology, June 22, 2006, Cambridge, MA Department of Cardiology, Twee Steden Ziekenhuis, May 31, 2006, Tilburg, NL Experimental Biology, April 1-5, 2006, San Fransisco, CA 2005: Department of Cardiology, VieCuri Medisch Centrum Noord Limburg, December 20, 2005, Venlo, NL Department of Cardiology, Academic Medical Center, December 15, 2005, Amsterdam, NL Department of Cardiology, University Hospital Utrecht, December 14, 2005, Utrecht, NL Material Sciences Program, University of New Hampshire, December 1, 2005, Durham, NH International Center for Integrative Medicine Symposium: Degenerative Disease – Regenerative Medicine, Treating Causes not Consequences, , Sept. 16-18, 2005, Grand Rapids, MI The Jackson Laboratory, April 28, 2005, Bar Harbor, ME 2004: Centers for Molecular and Regenerative Medicine, Maine Medical Center Research Institute, December 9, 2004, Scarborough, ME Third Annual Biological Therapeutics Symposium: Therapeutic Angiogenesis and Myogenesis, November 6, 2004, Atlanta, GA Joint Workshop on Stem and Mesenchymal Cells, Vasculogenesis and Angiogenesis, Maine Medical Center, Dartmouth Medical School, May 9-10, 2004, Lebanon, NH 2003: Second Annual Biological Therapeutics Symposium: Clinical Trials in Cell and Angiogenic Therapies, November 8, 2003, Orlando, FL New England Working Group Molecular Imaging Symposium, July 25, 2003, Yale, CT Society for Interventional Radiology Annual Scientific Meeting, March 30, Salt Lake City, UT 2002: New England Cardiac Catheterization Conference, October 4-5, 2002, Stowe, VT BIBLIOGRAPHY: Journal Articles: 1. 2. 3. 4. 5. 6. De Muinck E, Wagner G, v.d. Ven LLM, Lie KI. Comparison of the effects of two doses of Bisoprolol on exercise tolerance in exercise induced stable angina pectoris. Eur Heart J 1987;suppl.M:31-35. De Muinck E, Wagner G, van der Ven LLM, Lie KI. El Bisoprolol en la angina de pecho estable inducido por el esfuerzo. Drugs of Today 1989;suppl.2:55-62. De Muinck E, Lie K.I. Safety and efficacy of betablockers in the treatment of stable angina pectoris. J Cardiovasc Pharmacol 1990;suppl.5:S123-S128. De Muinck E, Lie KI, von Mengden HJ, Reck R, Verkenne P. Bisoprolol in myocardial infarction. J Cardiovasc Pharmacol 1990;suppl.5:S196-S200. De Muinck E, Ven van der L, Buchner-Moell D, Lie K, on behalf of the MIRSA study group. Comparison of the safety and efficacy of bisoprolol versus atenolol in stable exercise induced angina pectoris. A Multicentre International Randomized Study on Angina Pectoris (MIRSA). J Cardiovasc Pharmacol 1992;19:870-875. De Muinck ED, van Dijk RB, den Heijer P, Meeder J, Lie KI. Autoperfusion balloon catheter for Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 16 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. complicated angioplasty: a prospective study with retrospective controls. Int J Cardiol 1992;37:317327. Van de Ven LLM, de Muinck ED, van Herwaarden RHBM, Buchner-Möll D, Lie KI. Een vergelijkend onderzoek naar het anti-angineuze effect van bisoprolol (Emcor®) en atenolol. Een Multicenter Internationale Gerandomiseerde Studie bij Angina Pectoris (MIRSA). J Drugther Res 1992;9:268-273. Pentinga M, Meeder JG, Crijns HJGM, de Muinck ED, Wiesfeld A, Lie KI. Late onset atrioventricular nodal tachycardia. Int J Cardiol 1993;38:293-298. Rakhorst G, Verkerke GJ, de Muinck ED. Hart en pomp, mechanische circulatie ondersteuning. Klinische Fysica 1993;2:74-80. Verkerke GJ, de Muinck ED, Rakhorst G, Blanksma PK. The P.U.C.A. pump: a left ventricular assist device. Artif Organs 1993;17:365-368. Van Dijk RB, den Heijer P, de Muinck ED, Lie KI. Internal balloon tamponade: a non-surgical method for removal of accidentally placed sheaths from the subclavian artery. Cath Cardiovasc Diagn 1993;29:325-328. De Muinck ED, Angelini P, van Dijk RB, Verkerke GJ, Rakhorst G, Lie KI. In vitro flow of fresh human blood through autoperfusion balloon catheters. Cath Cardiovasc Diagn 1993;30:58-62. De Muinck ED, Meeder JG, Magielse CPE, Bom VJJ, Verkerke GJ, Lie KI. Hemolysis in fresh human blood with a new hemoperfusion pump to prevent myocardial ischemia during coronary angioplasty. Technology and Health Care, 1993;1:165-170. De Muinck ED, Meeder JG, Magielse CPE, Bom VJJ, van Dijk RB, Verkerke GJ, Lie KI. Hemoperfusion during coronary angioplasty: first European experience with a new hemoperfusion pump. Artif Organs 1994;18:517-522. Rakhorst G, Verkerke GJ, Hensens AG, de Muinck ED, Blanksma PK, Pillon M, Juffer M. In vitro evaluation of the influence of pulsatile intraventricular pumping on ventricular pressure patterns. Artif Organs 1994;18:494-499. De Muinck ED, Verkerke GJ, Rakhorst G, van Dijk RB, Lie KI. Myocardial protection during coronary angioplasty with autoperfusion and forced perfusion: an in vitro comparison. Int J Artif Organs 1994;17:83-87. De Muinck ED. Nieuwe dottertechniek. Samenvatting proefschrift. Tijdschr Gerontol Geriatr 1994;25:173. De Muinck ED. Pompje maakt ook dotteren bij erg zwak hart mogelijk. Mens en Wetenschap 1994;6:390. De Muinck ED, den Heijer P, van Dijk RB, Crijns HJGM, Hillege JL, Twisk SP, Lie KI. Autoperfusion balloon versus stent for acute or threatened closure during coronary angioplasty. Am J Cardiol 1994;74:1002-1005. De Muinck ED. Geforceerde coronair perfusie tijdens percutane transluminale coronair angioplastiek. Modern Medicine 1995;February:107-109. De Muinck ED. Distal coronary hemoperfusion during percutaneous transluminal coronary angioplasty. Samenvatting proefschrift. Cardiologie 1995;2:84. Meijer J, de Haan S, de Muinck ED. Geforceerde coronair perfusie tijdens percutane transluminal coronair angioplastiek: verpleegkundige aspecten. Cordiaal 1995;February:25-30 De Muinck ED. Distal coronary hemoperfusion during percutaneous transluminal coronary angioplasty. Cardiologie 1995;2:241-247. De Muinck ED. Bail-out coronary angioplasty. J Invasive Cardiol 1995;7,suppl B:32B-38B. De Muinck et al. The Perfusion Angioplasty Symposium. Panel discussion. J Invasive Cardiol 1995;7,suppl B:50B-56B. Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 17 26. De Muinck ED, den Heijer P, van Dijk RB, Crijns HJGM, Hillige HL, Lie KI. Distal coronary hemoperfusion during percutaneous transluminal coronary angioplasty. Cath Cardiovasc Diagn 1996;37:233-240. 27. De Muinck ED, de Swart JBRM, van Ommen GVA, Bär FWHM. Het gebruik van intracoronaire stents. Hartbulletin 1996;67-71. 28. van de Ven LLM, Crijns HJGM, De Muinck ED, van Gelder IC, van Wijk LM Lie KI. Electrophysiologic and antiarrhythmic effects of intravenous Bisoprolol in atrioventricular nodal reentry tachycardia. Current Therapeutic Research 1996;57:950-958. 29. Rodriguez LM, Smeets JLRM, Timmermans C, Blommaert D, van Dantzig JM, De Muinck ED, Wellens HJJ. Radiofrequency catheter ablation of sustained monomorphic ventricular tachycardia in hypertrophic cardiomyopathy. Cardiovasc. Electrophysiol. 1997;8:803-806. 30. De Muinck ED, van Gilst W, van der Laarse A, Doevendans PAFM. Molecular Cardiology. Part 3: restenosis. Cardiologie 1997;4:469-476. 31. Palmen M, van der Zee R, Daemen MJAP, De Muinck ED, Lucassen AJN, Doevendans PAFM. Molecular Cardiology. Part 6: Cardiac angiogenesis and growth factors. Cardiologie, 1998;5:406413. 32. Hofstra L, De Muinck ED, Doevendans PAFM. Molecular Cardiology. Part 7: Apoptosis in the cardiovascular system. Cardiologie 1998;5:589-593. 33. Doevendans PA, Daemen MJ, De Muinck ED, Smits JF. Cardiovascular phenotyping in mice. Cardiovasc. Res. 1998;39:34-49. 34. Lutgens E, Daemen M, Kockx M. Doevendans PA, Hofker M, Havekes L, Wellens HJJ, de Muinck ED. Atherosclerosis in APOE*3 Leiden Transgenic Mice from Proliferative to Atheromatous Stage. Circulation 1999;99:276-283. 35. Lutgens E, de Muinck ED, Kitslaar PJ, Tordoir JH, Wellens HJJ, Daemen MJ. Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. Cardiovasc. Res. 1999;41:473-479. 36. Lutgens E, Daemen M, de Muinck ED, Debets J, Leenders P, Smits JF. Chronic myocardial infarction in the mouse: cardiac structural and functional changes. Cardiovasc. Res. 1999;41:586593. 37. Engelen D, Gorgels Ap, Cheriex EC, de Muinck ED, Oude Ophuis AJ, Dassen WR, Vainer J, van Ommen VG, Wellens HJJ. Value of the electrocardiogram in localizing the occlusion site in the left anterior descending coronary artery in acute anterior myocardial infarction. J. Am. Coll. Cardiol. 1999;34:389-395. 38. Lutgens E, Gorelik L, Daemen MJ, de Muinck ED, Grewal IS, Koteliansky VE, Flavell RA. Requirement for CD 154 in the progression of atherosclerosis. Nature Med., 1999;5:1313-1316. 39. Hofstra L, Liem H, Dumont E, Boersma H, van Heerde W, Doevendans P, de Muinck ED, Wellens HJJ, Kemerink G, Reutelingsperger C, Heidendal G. Visualisation of cell death in vivo in patients with acute myocardial infarction. Lancet 2000;356:209-212. 40. F. Bär, J. Vainer, Stevenhagen J, Neven K, Aalbregt R, Oude Ophuis T, van Ommen V, de Swart H, de Muinck ED, Dassen WR, Wellens HJJ. Ten years experience with early angioplasty in 759 patients with acute myoacardial infarction . J. Am. Coll. Cardiol. 2000;36:51-58. 41. Dumont E, Hofstra L, van Heerde W, van den Eijnde S, Doevendans P, de Muinck ED, Daemen M, Smits J, Frederik P, Wellens H, Daemen M, Reutelingsperger Ch. Cardiomyocyte Death Induced by Myocardial Iscyhemia and Reperfusion. Circulation 2000;102:1564-1568. 42. Kliffen M, Lutgens E, Daemen M, de Muinck ED, Mooy C, de Jong P. The APOE*3-Leiden mouse as an animal model for basal laminar deposits. Br J Ophtalmol 2000;84:1415-1419. 43. W. Rompelberg, S. Haegmans, E. de Muinck. Foliumzuur: een nieuwe manier in de behandeling Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 18 van vaatvernauwing? Cordiaal 2000;21:155-157. 44. Lutgens E, de Muinck ED, Heeneman S, Daemen MJ. Compensatory enlargement and stenosis develop in apoE(-/-) and apoE*3-Leiden transgenic mice. Arterioscler Thromb Vasc Biol 2001;21:1359-65. 45. Bech GJ, de Bruyne B, Pijls NH, de Muinck ED, Hoorntje JC, Escaned J, Stella PR, Boersma E, Bartunek J, Koolen JJ, Wijns W. Fractional flow reserve to determine the appropriateness of angioplasty in moderate coronary stenosis: a randomized trial. Circulation 2001;103:2928-2934. 46. Chamuleau SA, Tio RA, de Cock C, de Muinck ED, Pijls NH, van Eck-Smit BL, Koch KT, Meeuwissen M, Dijkgraaf MG, de Jong A, Verberne HJ, van Liebergen RA, Laarman GJ, Tijssen JG, Piek JJ. Prognostic value of coronary blood flow velocity and myocardial perfusion in intermediate coronary narrowings and multivessel disease. J Am Coll Cardiol 2002;39:852-858. 47. Mandinov LA, Mandinova A, Kyurkchiev S, Kjurkchiev D, Kehayov I, Kolev V, Soldi R, Bagala C, de Muinck ED, Lindner V, Post MJ, Simons M, Bellum S, Prudovsky I, Maciag T. Copper chelation represses the vascular response to injury. Proc Natl Acad Sci U.S.A. 2003;100:6700. 48. Khurana R, Zhuang ZZ, Bhardway S, Murakami M, de Muinck E, Yla-Herttuala S, Ferrara N, Martin J, Zachary I, Simons M. Angiogenesis dependent and independent phases of intimal hyperplasia. Circulation 2004;110:2436-2443. 49. Baklanov DV, de Muinck ED, Thompson CA, Pearlman JD. Novel double contrast MRI technique for intramyocardial detection of percutaneously transplanted autologous cells. Magn Reson Med 2004;52:1438-1442. 50. Baklanov DV, de Muinck ED, Simons M, Moodie KL, Arbuckle BE, Thompson CA, Palac RT. Live 3D echo guidance of catheter-based injections. Cathet Cardiovasc Intervent 2005;65:340-345. 51. Jun Yu, Ebo D. de Muinck, Zhenwu Zhuang, Mary Drinane, Katalin Kauser, Gabor M. Rubanyi, Hu Sheng Qian,Takahisa Murata, Bruno Escalante, and William C. Sessa. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. PNAS 2005;102:10999-11004. 52. Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Heng Huang, Fillia Makedon, Justin Pearlman. An interactive 3D visualization and manipulation tool for effective assessment of angiogenesis and arteriogenesis using computed tomographic angiography. Proc. SPIE 2005;7544:848. 53. Zhen W. Zhuang, Ling Gao, Masahiro Murakami, Justin D Pearlman, Terry J Sackett, Michael Simons, Ebo D. de Muinck. Multidetector row computed tomographic angiography with threedimensional volume rendering in rodents: non-invasive quantification of arteriogenesis. Radiology 2006; 240:698-707. 54. Baklanov DV, Moodie KM, McCarthy FE, Mandrusov E, Chiu J, Aswonge G, Cheng J, Chow M, Simons M, de Muinck ED. Comparison of transendocardial and retrograde coronary venous intramyocardial catheter delivery systems in healthy and infarcted pigs. Cath Cardiovasc Interv 2006: 68:416-423. 55. Mandinov L, Moodie KL, Mandinova A, Zhuang Z, Redican F, Baklanov D, Lindner V, Maciag T, Simons M, de Muinck ED. Inhibition of in-stent restenosis by oral copper chelation in porcine coronary arteries. Am J Physiol: Heart and Circulatory Physiology 2006;291:H2692-H2697. 56. Buehler A, van Zandvoort, MAJM, Stelt BJ, Hackeng TM, Schrans-Stassen BHGJ, Bennaghmouch A, Hofstra L, Cleutjens JPM, Duijvestijn A, Smeets MB, de Kleijn DPV, Post MJ, de Muinck ED. c-NGR a novel homing sequence for targeted molecular imaging of murine cardiac angiogenesis in vivo. Arteriosclerosis Thrombosis and Vascular Biology 2006;26:2681-2687. Curriculum vitae, Ebo D. de Muinck, M.D., Ph.D. Page 19 57. Sherman JA, Hall A, Malenka DJ, de Muinck ED, Simons M. Humoral and cellular factors responsible for coronary collateral formation. Am J Cardiol 2006:89:1194-1197. 58. de Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswamy SK, Ghatpande S, Engelman RN, Das DK, Simons M. Protection Against Myocardial Ischemia–Reperfusion Injury by the Angiogenic Masterswitch Protein PR 39 Gene Therapy: The Roles of HIF1α Stabilization and FGFR1 Signaling. Antioxidants & Redox Signaling 2007;9:437-445. 59. Listz Maurice R, Fromageau J, Roy Cardinal M-H, Doyley M, de Muinck E, Robb J, Cloutier G. Characterization of Atherosclerotic Plaques and Mural Thrombi with Intravascular Ultrasound Elastography: A Potential Method Evaluated in an Aortic Rabbit Model and a Human Coronary Artery. IEEE-TITB 2008;12:290-298. Reviews: 1. de Muinck ED, Simons M. Re-evaluating therapeutic neovascularization. J Mol Cell Cardiol 2004;36:25-32. 2. Ebo D. de Muinck, Craig Thompson, Michael Simons. Cell based regenerative therapy for cardiovascular disease. Gene Ther 2006;13:659. Editorials: Ebo D. de Muinck, Michael Simons. Calling on reserves. Granulocyte colony stimulating growth factor in cardiac repair. Circulation 2005;112:3033. INVITED PAPERS: Book Chapters: E.D. de Muinck, J. D. Pearlman. Targeted Magnetic Resonance Imaging of Angiogenesis in the Vascular System. In: Cardiovascular Molecular Imaging. Informa Health Care, New York, NY, 2007. E.D. de Muinck. Atherosclerosis: Focus on Epigenetics and Nutrition. Taylor & Francis Group, London, UK Reviews: E.D. de Muinck. Cell- and gene therapy for cardiac regenerative therapy. Antioxidant Redox Signaling, 2009;11: 2025–2042. L. W. Dobrucki, E.D. de Muinck, J.R. Lindner, A.J. Sinusas. Multimodality Imaging Approaches to Angiogenesis. . J Nucl Med – Supplement, 2010: in press